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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:puromycin
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Accession:CHEBI:17939 term browser browse the term
Definition:An aminonucleoside antibiotic, derived from the Streptomyces alboniger bacterium, that causes premature chain termination during translation taking place in the ribosome.
Synonyms:exact_synonym: 3'-deoxy-N,N-dimethyl-3'-(O-methyl-L-tyrosinamido)adenosine
 related_synonym: (S)-3'-((2-Amino-3-(4-methoxyphenyl)-1-oxopropyl)amino)-3'-deoxy-N,N-dimethyladenosine;   3'-(L-alpha-Amino-p-methoxyhydrocinnamamido)-3'-deoxy-N,N-dimethyladenosine;   3'-[[(2S)-2-amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-diemthyladenosine;   9-{3-deoxy-3-[(O-methyl-L-tyrosyl)amino]-beta-D-xylofuranosyl}-N,N-dimethyl-9H-purin-6-amine;   Achromycin;   Formula=C22H29N7O5;   InChI=1S/C22H29N7O5/c1-28(2)19-17-20(25-10-24-19)29(11-26-17)22-18(31)16(15(9-30)34-22)27-21(32)14(23)8-12-4-6-13(33-3)7-5-12/h4-7,10-11,14-16,18,22,30-31H,8-9,23H2,1-3H3,(H,27,32)/t14-,15+,16+,18+,22+/m0/s1;   InChIKey=RXWNCPJZOCPEPQ-NVWDDTSBSA-N;   SMILES=COc1ccc(C[C@H](N)C(=O)N[C@@H]2[C@@H](CO)O[C@H]([C@@H]2O)n2cnc3c(ncnc23)N(C)C)cc1;   puromicina;   puromycine;   puromycinum
 alt_id: CHEBI:14970;   CHEBI:26402;   CHEBI:45182;   CHEBI:8641
 xref: CAS:53-79-2;   DrugBank:DB08437;   KEGG:C01610;   KEGG:D05653;   KNApSAcK:C00001507;   LINCS:LSM-2788
 xref_mesh: MESH:D011691
 xref: PMID:13945541;   PMID:15843471;   PMID:18322149;   PMID:323854;   Reaxys:70234;   Wikipedia:Puromycin
 cyclic_relationship: is_conjugate_base_of CHEBI:60255


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puromycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases transport
affects response to substance
increases expression		 ISO
EXP		 ABCB1 protein results in increased transport of Puromycin
ABCB1A protein affects the susceptibility to Puromycin
Puromycin results in increased expression of ABCB1A mRNA; Puromycin results in increased expression of ABCB1A protein		 CTD PMID:14675146 PMID:20018165 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 increases expression ISO Puromycin results in increased expression of ABCC1 mRNA CTD PMID:20018165 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO Puromycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased degradation of AHR protein]
Puromycin inhibits the reaction [Omeprazole results in increased expression of AHR protein]; Puromycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of AHR protein]		 CTD PMID:10777561 PMID:25797602 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Aldh3a1 aldehyde dehydrogenase 3 family, member A1 multiple interactions EXP Puromycin promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of ALDH3A1 mRNA] CTD PMID:1953764 NCBI chr10:45,892,993...45,902,680
Ensembl chr10:45,892,924...45,902,681 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator affects localization ISO Puromycin affects the localization of BAX protein CTD PMID:18339127 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions		 ISO Puromycin results in decreased expression of BCL2 protein
Melatonin promotes the reaction [Puromycin results in decreased expression of BCL2 protein]		 CTD PMID:21244482 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
decreases expression		 ISO Melatonin promotes the reaction [Puromycin results in decreased expression of BCL2L1 protein] CTD PMID:21244482 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 ISO Melatonin promotes the reaction [Puromycin results in increased activity of CASP3 protein] CTD PMID:14502240 PMID:21244482 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 increases activity ISO Puromycin results in increased activity of CASP9 protein CTD PMID:14502240 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO Puromycin results in decreased expression of CCL2 protein CTD PMID:20116850 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 decreases expression ISO Puromycin results in decreased expression of CCL4 protein CTD PMID:20116850 NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231 		JBrowse link
G Cd2ap CD2-associated protein decreases expression ISO Puromycin results in decreased expression of CD2AP mRNA CTD PMID:15673299 NCBI chr 9:18,086,744...18,182,744
Ensembl chr 9:18,086,984...18,182,199 		JBrowse link
G Cdh3 cadherin 3 decreases expression ISO Puromycin results in decreased expression of CDH3 mRNA CTD PMID:15673299 NCBI chr19:34,393,596...34,444,084
Ensembl chr19:34,393,727...34,444,084 		JBrowse link
G Ctnnb1 catenin beta 1 affects localization ISO Puromycin affects the localization of CTNNB1 protein CTD PMID:15673299 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression		 ISO [Puromycin co-treated with Tetrachlorodibenzodioxin] results in increased expression of CYP1A1 mRNA
Puromycin results in increased expression of CYP1A1 mRNA
Puromycin promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]		 CTD PMID:2985607 PMID:15385644 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Def6 DEF6 guanine nucleotide exchange factor affects localization ISO Puromycin affects the localization of DEF6 protein CTD PMID:22829599 NCBI chr20:6,268,579...6,290,030
Ensembl chr20:6,268,601...6,289,961 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Puromycin results in increased expression of HMOX1 CTD PMID:26260164 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Il6r interleukin 6 receptor decreases expression ISO Puromycin results in decreased expression of IL6R protein modified form CTD PMID:20116850 NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536 		JBrowse link
G Irf1 interferon regulatory factor 1 multiple interactions ISO Puromycin inhibits the reaction [nickel sulfate results in increased expression of IRF1 protein] CTD PMID:20525893 NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166 		JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions
decreases expression		 ISO Puromycin inhibits the reaction [GW 707 results in increased expression of LDLR mRNA]; Puromycin inhibits the reaction [Quercetin results in increased expression of LDLR mRNA]; Puromycin inhibits the reaction [Quercetin results in increased expression of LDLR protein]
Puromycin results in decreased expression of LDLR mRNA; Puromycin results in decreased expression of LDLR protein		 CTD PMID:12524230 PMID:22388943 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580 		JBrowse link
G Mir122 microRNA 122 multiple interactions EXP Puromycin results in decreased expression of and results in decreased secretion of MIR122 mRNA CTD PMID:30682439 NCBI chr18:58,758,703...58,758,787 JBrowse link
G Mir143 microRNA 143 multiple interactions EXP Puromycin results in decreased expression of and results in decreased secretion of MIR143 mRNA CTD PMID:30682439 NCBI chr18:55,101,006...55,101,110
Ensembl chr18:55,101,006...55,101,110 		JBrowse link
G Mir155 microRNA 155 affects expression EXP Puromycin affects the expression of MIR155 CTD PMID:30169741 NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718 		JBrowse link
G Mir3473 microRNA 3473 multiple interactions EXP Puromycin results in increased expression of and results in increased secretion of MIR3473 mRNA CTD PMID:30682439 NCBI chr13:39,499,246...39,499,312
Ensembl chr13:39,499,246...39,499,312 		JBrowse link
G Nefh neurofilament heavy chain decreases degradation EXP Puromycin results in decreased degradation of NEFH mRNA CTD PMID:1280263 NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351 		JBrowse link
G Nefl neurofilament light chain decreases degradation EXP Puromycin results in decreased degradation of NEFL mRNA CTD PMID:1280263 NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793 		JBrowse link
G Nefm neurofilament medium chain decreases degradation EXP Puromycin results in decreased degradation of NEFM mRNA CTD PMID:1280263 NCBI chr15:42,360,449...42,365,753
Ensembl chr15:42,360,454...42,365,755 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO Puromycin inhibits the reaction [Dexamethasone affects the localization of NR3C1 protein] CTD PMID:21569845 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Optn optineurin multiple interactions ISO OPTN protein affects the reaction [Puromycin results in increased secretion of VEGFA protein] CTD PMID:25096716 NCBI chr17:73,209,572...73,260,251
Ensembl chr17:73,209,575...73,260,251 		JBrowse link
G Ptger4 prostaglandin E receptor 4 multiple interactions ISO [Puromycin co-treated with PTGS2 protein] results in increased expression of PTGER4 mRNA; [Puromycin co-treated with PTGS2 protein] results in increased expression of PTGER4 protein CTD PMID:19643929 NCBI chr 2:54,330,563...54,347,451
Ensembl chr 2:54,335,424...54,346,670 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [Puromycin co-treated with PTGS2 protein] results in increased expression of PTGER4 mRNA; [Puromycin co-treated with PTGS2 protein] results in increased expression of PTGER4 protein; [Puromycin co-treated with PTGS2 protein] results in increased expression of TBXA2R mRNA; [Puromycin co-treated with PTGS2 protein] results in increased expression of TBXA2R protein CTD PMID:19643929 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Tbxa2r thromboxane A2 receptor multiple interactions ISO [Puromycin co-treated with PTGS2 protein] results in increased expression of TBXA2R mRNA; [Puromycin co-treated with PTGS2 protein] results in increased expression of TBXA2R protein CTD PMID:19643929 NCBI chr 7:8,383,347...8,390,753
Ensembl chr 7:8,383,378...8,388,176 		JBrowse link
G Tiparp TCDD-inducible poly(ADP-ribose) polymerase multiple interactions ISO Puromycin promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of TIPARP mRNA] CTD PMID:12147270 NCBI chr 2:149,753,682...149,780,327
Ensembl chr 2:149,753,682...149,780,327 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression
increases secretion
multiple interactions		 ISO Puromycin results in decreased expression of VEGFA protein
Puromycin results in increased secretion of VEGFA protein
OPTN protein affects the reaction [Puromycin results in increased secretion of VEGFA protein]		 CTD PMID:20116850 PMID:25096716 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    role 19854
      biological role 19852
        antimicrobial agent 18266
          puromycin 34
            puromycin 5'-phosphate + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    p-block element atom 19849
                      carbon group element atom 19766
                        carbon atom 19785
                          organic molecular entity 19785
                            heteroorganic entity 19541
                              organochalcogen compound 19301
                                organooxygen compound 19193
                                  carbohydrates and carbohydrate derivatives 15275
                                    carbohydrate 15302
                                      carbohydrate derivative 14313
                                        glycosyl compound 13078
                                          N-glycosyl compound 5824
                                            nucleoside 5734
                                              ribonucleoside 1144
                                                purine ribonucleoside 813
                                                  adenosines 794
                                                    puromycins 34
                                                      puromycin 34
                                                        puromycin 5'-phosphate + 0
paths to the root