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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:calcidiol
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Accession:CHEBI:17933 term browser browse the term
Definition:A hydroxycalciol that is calciol in which the hydrogen at position 25 has been replaced by a hydroxy group. A prehormone resulting from the oxidation of calciol in the liver, it is further hydroxylated in the kidney to give calcitriol, the active form of vitamin D3.
Synonyms:related_synonym: (3S,5Z,7E)-9,10-secocholesta-5,7,10-triene-3,25-diol;   (3beta,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-3,25-diol;   (5Z,7E)-(3S)-9,10-secocholesta-5,7,10(19)-triene-3,25-diol;   25(OH)D3;   25-hydroxycholecalciferol;   25-hydroxyvitamin D3;   3-{2-[1-(5-HYDROXY-1,5-DIMETHYL-HEXYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXANOL;   Calcifediol anhydrous;   Formula=C27H44O2;   InChI=1S/C27H44O2/c1-19-10-13-23(28)18-22(19)12-11-21-9-7-17-27(5)24(14-15-25(21)27)20(2)8-6-16-26(3,4)29/h11-12,20,23-25,28-29H,1,6-10,13-18H2,2-5H3/b21-11+,22-12-/t20-,23+,24-,25+,27-/m1/s1;   InChIKey=JWUBBDSIWDLEOM-DTOXIADCSA-N;   Rayaldee;   SMILES=[H][C@@]1(CC[C@]2([H])[C@]1(C)CCC\\C2=C/C=C1/C[C@@H](O)CCC1=C)[C@H](C)CCCC(C)(C)O;   calcifediol;   calcifediolum
 alt_id: CHEBI:13931;   CHEBI:19815;   CHEBI:3304;   CHEBI:46387
 xref: Beilstein:4270041;   CAS:19356-17-3;   DrugBank:DB00146;   Drug_Central:464;   KEGG:C01561;   LIPID_MAPS_instance:LMST03020246
 xref_mesh: MESH:D002112
 xref: PDBeChem:VDY;   PMID:16549446;   PMID:18689406;   PMID:22487892;   PMID:22536761;   PMID:23090338;   PMID:23566108;   PMID:9080330;   Reaxys:4270041;   Wikipedia:Calcifediol


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calcidiol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aard alanine and arginine rich domain containing protein increases expression EXP Calcifediol deficiency results in increased expression of AARD mRNA CTD PMID:17293106 NCBI chr 7:83,364,478...83,369,319
Ensembl chr 7:83,364,204...83,369,317 		JBrowse link
G Actb actin, beta decreases expression EXP Calcifediol deficiency results in decreased expression of ACTB mRNA CTD PMID:17293106 NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO Calcifediol inhibits the reaction [TNF protein results in increased phosphorylation of AKT1 protein] CTD PMID:34255241 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Aldoa aldolase, fructose-bisphosphate A decreases expression EXP Calcifediol deficiency results in decreased expression of ALDOA mRNA CTD PMID:17293106 NCBI chr 1:181,402,275...181,407,476
Ensembl chr 1:181,402,275...181,406,182 		JBrowse link
G Alpl alkaline phosphatase, biomineralization associated increases expression
multiple interactions		 ISO Calcifediol results in increased expression of ALPL mRNA; Calcifediol results in increased expression of ALPL protein
CYP27B1 protein promotes the reaction [Calcifediol results in increased expression of ALPL mRNA]; CYP27B1 protein promotes the reaction [Calcifediol results in increased expression of ALPL protein]; Ketoconazole inhibits the reaction [Calcifediol results in increased expression of ALPL mRNA]		 CTD PMID:21542014 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446 		JBrowse link
G Apob apolipoprotein B decreases expression EXP Calcifediol deficiency results in decreased expression of APOB mRNA CTD PMID:17293106 NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497 		JBrowse link
G Aqp4 aquaporin 4 decreases expression EXP Calcifediol deficiency results in decreased expression of AQP4 mRNA CTD PMID:17293106 NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856 		JBrowse link
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 decreases expression EXP Calcifediol deficiency results in decreased expression of ATP1A1 mRNA CTD PMID:17293106 NCBI chr 2:189,020,722...189,048,826
Ensembl chr 2:189,020,722...189,048,837 		JBrowse link
G Atp1a3 ATPase Na+/K+ transporting subunit alpha 3 decreases expression EXP Calcifediol deficiency results in decreased expression of ATP1A3 mRNA CTD PMID:17293106 NCBI chr 1:80,572,790...80,601,936
Ensembl chr 1:80,572,796...80,601,918 		JBrowse link
G Atp1b1 ATPase Na+/K+ transporting subunit beta 1 decreases expression EXP Calcifediol deficiency results in decreased expression of ATP1B1 mRNA CTD PMID:17293106 NCBI chr13:76,786,580...76,807,096
Ensembl chr13:76,786,578...76,807,459 		JBrowse link
G Atp6v1b2 ATPase H+ transporting V1 subunit B2 decreases expression EXP Calcifediol deficiency results in decreased expression of ATP6V1B2 mRNA CTD PMID:17293106 NCBI chr16:20,617,515...20,641,651
Ensembl chr16:20,617,518...20,641,745 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression
multiple interactions		 ISO Calcifediol results in decreased expression of BAX mRNA; Calcifediol results in decreased expression of BAX protein
Ketoconazole inhibits the reaction [Calcifediol results in decreased expression of BAX mRNA]		 CTD PMID:21542014 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcat1 branched chain amino acid transaminase 1 decreases expression EXP Calcifediol deficiency results in decreased expression of BCAT1 mRNA CTD PMID:17293106 NCBI chr 4:177,964,834...178,046,573
Ensembl chr 4:177,964,834...178,046,597 		JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
multiple interactions		 ISO Calcifediol results in increased expression of BCL2 mRNA; Calcifediol results in increased expression of BCL2 protein
Ketoconazole inhibits the reaction [Calcifediol results in increased expression of BCL2 mRNA]		 CTD PMID:21542014 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bnip3 BCL2 interacting protein 3 multiple interactions ISO Calcifediol inhibits the reaction [TNF protein promotes the reaction [BNIP3 protein binds to MAP1LC3B protein]]; Calcifediol inhibits the reaction [TNF protein results in increased expression of and affects the localization of BNIP3 protein]
Calcifediol inhibits the reaction [TNF protein results in increased expression of BNIP3 protein]		 CTD PMID:34255241 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359 		JBrowse link
G Canx calnexin decreases expression EXP Calcifediol deficiency results in decreased expression of CANX mRNA CTD PMID:17293106 NCBI chr10:34,623,865...34,656,866
Ensembl chr10:34,625,191...34,656,821 		JBrowse link
G Cat catalase decreases expression EXP Calcifediol deficiency results in decreased expression of CAT mRNA CTD PMID:17293106 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Calcifediol results in decreased expression of CCND1 protein CTD PMID:21542014 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cd247 Cd247 molecule multiple interactions ISO Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]; Ketoconazole inhibits the reaction [Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]] CTD PMID:24792400 NCBI chr13:78,043,302...78,118,437
Ensembl chr13:78,043,307...78,122,263 		JBrowse link
G Cd28 Cd28 molecule multiple interactions ISO Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]; Ketoconazole inhibits the reaction [Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]] CTD PMID:24792400 NCBI chr 9:62,166,324...62,194,674
Ensembl chr 9:62,166,192...62,194,685 		JBrowse link
G Cd3d CD3 delta subunit of T-cell receptor complex multiple interactions ISO Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]; Ketoconazole inhibits the reaction [Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]] CTD PMID:24792400 NCBI chr 8:45,287,803...45,293,342
Ensembl chr 8:45,288,749...45,301,809 		JBrowse link
G Cd3e CD3 epsilon subunit of T-cell receptor complex multiple interactions ISO Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]; Ketoconazole inhibits the reaction [Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]] CTD PMID:24792400 NCBI chr 8:45,303,848...45,315,005
Ensembl chr 8:45,303,852...45,315,022 		JBrowse link
G Cd3g CD3 gamma subunit of T-cell receptor complex multiple interactions ISO Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]; Ketoconazole inhibits the reaction [Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]] CTD PMID:24792400 NCBI chr 8:45,280,797...45,287,271
Ensembl chr 8:45,281,204...45,287,147 		JBrowse link
G Cdh2 cadherin 2 decreases expression EXP Calcifediol deficiency results in decreased expression of CDH2 protein CTD PMID:26210580 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Calcifediol results in increased expression of CDKN1A protein CTD PMID:21542014 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Ckb creatine kinase B decreases expression EXP Calcifediol deficiency results in decreased expression of CKB mRNA CTD PMID:17293106 NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315 		JBrowse link
G Clta clathrin, light chain A increases expression EXP Calcifediol deficiency results in increased expression of CLTA mRNA CTD PMID:17293106 NCBI chr 5:58,244,253...58,263,480
Ensembl chr 5:58,245,442...58,263,472 		JBrowse link
G Cplx2 complexin 2 decreases expression EXP Calcifediol deficiency results in decreased expression of CPLX2 mRNA CTD PMID:17293106 NCBI chr17:10,219,577...10,292,835
Ensembl chr17:10,222,347...10,293,855 		JBrowse link
G Cspg5 chondroitin sulfate proteoglycan 5 decreases expression EXP Calcifediol deficiency results in decreased expression of CSPG5 mRNA CTD PMID:17293106 NCBI chr 8:110,220,506...110,234,766
Ensembl chr 8:110,220,653...110,234,758 		JBrowse link
G Cyb5a cytochrome b5 type A decreases expression EXP Calcifediol deficiency results in decreased expression of CYB5A mRNA CTD PMID:17293106 NCBI chr18:78,213,067...78,245,677
Ensembl chr18:78,202,342...78,258,535
Ensembl chr18:78,202,342...78,258,535 		JBrowse link
G Cycs cytochrome c, somatic increases expression EXP Calcifediol deficiency results in increased expression of CYCS mRNA CTD PMID:17293106 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 multiple interactions
increases expression		 ISO Dihydrotestosterone inhibits the reaction [Calcifediol results in increased expression of CYP24A1 mRNA]; Tretinoin inhibits the reaction [Calcifediol results in increased expression of CYP24A1 mRNA]
Ketoconazole inhibits the reaction [Calcifediol results in increased expression of CYP24A1 mRNA]		 CTD PMID:16289102 PMID:16524720 PMID:18840526 PMID:21542014 PMID:24792400 NCBI chr 3:159,275,947...159,290,383
Ensembl chr 3:159,275,947...159,290,383 		JBrowse link
G Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 affects metabolic processing
multiple interactions
increases hydroxylation		 ISO
EXP		 CYP27B1 protein affects the metabolism of Calcifediol
CYP27B1 protein promotes the reaction [Calcifediol results in increased expression of ALPL mRNA]; CYP27B1 protein promotes the reaction [Calcifediol results in increased expression of ALPL protein]; CYP27B1 protein promotes the reaction [Calcifediol results in increased expression of IBSP mRNA]; CYP27B1 protein promotes the reaction [Calcifediol results in increased expression of RUNX2 mRNA]
CYP27B1 protein results in increased hydroxylation of Calcifediol		 CTD PMID:16061850 PMID:21542014 NCBI chr 7:62,869,340...62,876,242
Ensembl chr 7:62,871,297...62,876,241 		JBrowse link
G Cyp4b1 cytochrome P450, family 4, subfamily b, polypeptide 1 decreases expression EXP Calcifediol deficiency results in decreased expression of CYP4B1 mRNA CTD PMID:17293106 NCBI chr 5:129,139,019...129,176,860
Ensembl chr 5:129,139,038...129,156,348 		JBrowse link
G Dctn4 dynactin subunit 4 decreases expression EXP Calcifediol deficiency results in decreased expression of DCTN4 mRNA CTD PMID:17293106 NCBI chr18:53,982,355...54,009,409
Ensembl chr18:53,982,358...54,009,399 		JBrowse link
G Dlg1 discs large MAGUK scaffold protein 1 decreases expression EXP Calcifediol deficiency results in decreased expression of DLG1 mRNA CTD PMID:17293106 NCBI chr11:68,911,883...69,103,230
Ensembl chr11:68,911,883...69,102,689 		JBrowse link
G Dnm1l dynamin 1-like multiple interactions ISO Calcifediol inhibits the reaction [TNF protein affects the expression of and results in increased phosphorylation of DNM1L protein]
Calcifediol inhibits the reaction [TNF protein results in increased expression of DNM1L protein]		 CTD PMID:34255241 NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482 		JBrowse link
G Dpp6 dipeptidyl peptidase like 6 decreases expression EXP Calcifediol deficiency results in decreased expression of DPP6 mRNA CTD PMID:17293106 NCBI chr 4:7,589,386...8,508,666
Ensembl chr 4:7,591,009...8,508,532 		JBrowse link
G Eif4h eukaryotic translation initiation factor 4H decreases expression EXP Calcifediol deficiency results in decreased expression of EIF4H mRNA CTD PMID:17293106 NCBI chr12:22,083,155...22,099,876
Ensembl chr12:22,082,835...22,099,876 		JBrowse link
G Fgf23 fibroblast growth factor 23 multiple interactions EXP Calcifediol inhibits the reaction [Theophylline results in increased expression of FGF23 protein] CTD PMID:26851681 NCBI chr 4:159,914,267...159,923,821
Ensembl chr 4:159,914,272...159,923,821 		JBrowse link
G Fkbp1a FKBP prolyl isomerase 1A decreases expression EXP Calcifediol deficiency results in decreased expression of FKBP1A mRNA CTD PMID:17293106 NCBI chr 3:140,040,359...140,060,107
Ensembl chr 3:140,040,278...140,060,743 		JBrowse link
G Gabbr1 gamma-aminobutyric acid type B receptor subunit 1 decreases expression EXP Calcifediol deficiency results in decreased expression of GABBR1 mRNA CTD PMID:17293106 NCBI chr20:1,464,534...1,494,114
Ensembl chr20:1,464,534...1,493,994 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha decreases expression EXP Calcifediol deficiency results in decreased expression of GADD45A mRNA CTD PMID:17293106 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115 		JBrowse link
G Gas5 growth arrest specific 5 increases expression EXP Calcifediol deficiency results in increased expression of GAS5 mRNA CTD PMID:17293106 NCBI chr13:73,303,611...73,306,932 JBrowse link
G Gfap glial fibrillary acidic protein decreases expression EXP Calcifediol deficiency results in decreased expression of GFAP mRNA CTD PMID:17293106 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589 		JBrowse link
G Gja1 gap junction protein, alpha 1 decreases expression EXP Calcifediol deficiency results in decreased expression of GJA1 mRNA CTD PMID:17293106 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582 		JBrowse link
G Glul glutamate-ammonia ligase decreases expression EXP Calcifediol deficiency results in decreased expression of GLUL mRNA CTD PMID:17293106 NCBI chr13:65,969,053...66,035,121
Ensembl chr13:66,025,630...66,035,108 		JBrowse link
G Gna12 G protein subunit alpha 12 decreases expression EXP Calcifediol deficiency results in decreased expression of GNA12 mRNA CTD PMID:17293106 NCBI chr12:13,805,580...13,886,255
Ensembl chr12:13,805,698...13,886,255 		JBrowse link
G Gnai1 G protein subunit alpha i1 decreases expression EXP Calcifediol deficiency results in decreased expression of GNAI1 mRNA CTD PMID:17293106 NCBI chr 4:16,814,000...16,898,119
Ensembl chr 4:16,814,001...16,896,417 		JBrowse link
G Gnrhr gonadotropin releasing hormone receptor increases expression EXP Calcifediol deficiency results in increased expression of GNRHR mRNA CTD PMID:17293106 NCBI chr14:21,856,871...21,874,861
Ensembl chr14:21,856,871...21,874,861 		JBrowse link
G Guca2b guanylate cyclase activator 2B increases expression EXP Calcifediol deficiency results in increased expression of GUCA2B mRNA CTD PMID:17293106 NCBI chr 5:133,246,891...133,248,941
Ensembl chr 5:133,246,909...133,248,966 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO Calcifediol inhibits the reaction [TNF protein results in increased expression of HIF1A protein] CTD PMID:34255241 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 decreases expression EXP Calcifediol deficiency results in decreased expression of HSD17B4 mRNA CTD PMID:17293106 NCBI chr18:43,328,903...43,417,950
Ensembl chr18:43,328,824...43,417,952 		JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 decreases expression EXP Calcifediol deficiency results in decreased expression of HSP90AB1 mRNA CTD PMID:17293106 NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488 		JBrowse link
G Ibsp integrin-binding sialoprotein increases expression
multiple interactions		 ISO Calcifediol results in increased expression of IBSP mRNA
CYP27B1 protein promotes the reaction [Calcifediol results in increased expression of IBSP mRNA]; Ketoconazole inhibits the reaction [Calcifediol results in increased expression of IBSP mRNA]		 CTD PMID:21542014 NCBI chr14:5,439,825...5,452,570
Ensembl chr14:5,439,829...5,452,693 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Calcifediol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:34255241 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Igf1 insulin-like growth factor 1 increases expression EXP Calcifediol deficiency results in increased expression of IGF1 mRNA CTD PMID:17293106 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Ins2 insulin 2 affects secretion ISO Calcifediol affects the secretion of INS protein CTD PMID:24401716 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Kdr kinase insert domain receptor decreases expression EXP Calcifediol deficiency results in decreased expression of KDR mRNA CTD PMID:17293106 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Klc1 kinesin light chain 1 decreases expression EXP Calcifediol deficiency results in decreased expression of KLC1 mRNA CTD PMID:17293106 NCBI chr 6:130,823,416...130,866,729
Ensembl chr 6:130,823,419...130,867,031 		JBrowse link
G Krt14 keratin 14 increases expression EXP Calcifediol deficiency results in increased expression of KRT14 mRNA CTD PMID:17293106 NCBI chr10:85,137,786...85,142,054
Ensembl chr10:85,066,802...85,171,799 		JBrowse link
G Lre3 LINE retrotransposable element 3 decreases expression EXP Calcifediol deficiency results in decreased expression of LRE3 mRNA CTD PMID:17293106
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO Calcifediol inhibits the reaction [TNF protein promotes the reaction [BNIP3 protein binds to MAP1LC3B protein]]; Calcifediol inhibits the reaction [TNF protein results in increased expression of MAP1LC3B protein] CTD PMID:34255241 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 		JBrowse link
G Map2 microtubule-associated protein 2 decreases expression EXP Calcifediol deficiency results in decreased expression of MAP2 mRNA CTD PMID:17293106 NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Calcifediol inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein] CTD PMID:34255241 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Calcifediol inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein] CTD PMID:34255241 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 decreases expression EXP Calcifediol deficiency results in decreased expression of MAPK9 mRNA CTD PMID:17293106 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Marcks myristoylated alanine rich protein kinase C substrate decreases expression EXP Calcifediol deficiency results in decreased expression of MARCKS mRNA CTD PMID:17293106 NCBI chr20:40,685,315...40,691,012
Ensembl chr20:40,685,315...40,691,012 		JBrowse link
G Mff mitochondrial fission factor multiple interactions ISO Calcifediol inhibits the reaction [TNF protein results in increased expression of MFF protein] CTD PMID:34255241 NCBI chr 9:84,007,798...84,036,039
Ensembl chr 9:84,007,798...84,036,039 		JBrowse link
G Mobp myelin-associated oligodendrocyte basic protein decreases expression EXP Calcifediol deficiency results in decreased expression of MOBP mRNA CTD PMID:17293106 NCBI chr 8:119,869,504...119,899,605
Ensembl chr 8:119,869,626...119,899,563 		JBrowse link
G Nckap1 NCK-associated protein 1 decreases expression EXP Calcifediol deficiency results in decreased expression of NCKAP1 mRNA CTD PMID:17293106 NCBI chr 3:65,417,450...65,491,769
Ensembl chr 3:65,417,453...65,492,217 		JBrowse link
G Nsf N-ethylmaleimide sensitive factor, vesicle fusing ATPase decreases expression EXP Calcifediol deficiency results in decreased expression of NSF mRNA CTD PMID:17293106 NCBI chr10:88,727,912...88,857,375
Ensembl chr10:88,727,912...88,857,386 		JBrowse link
G P4hb prolyl 4-hydroxylase subunit beta decreases expression EXP Calcifediol deficiency results in decreased expression of P4HB mRNA CTD PMID:17293106 NCBI chr10:105,836,972...105,848,583
Ensembl chr10:105,836,982...105,848,500 		JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO Calcifediol results in decreased expression of PCNA protein CTD PMID:21542014 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pdia3 protein disulfide isomerase family A, member 3 decreases expression EXP Calcifediol deficiency results in decreased expression of PDIA3 mRNA CTD PMID:17293106 NCBI chr 3:108,388,189...108,412,013
Ensembl chr 3:108,388,245...108,413,236 		JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 increases expression EXP Calcifediol deficiency results in increased expression of PDPK1 mRNA CTD PMID:17293106 NCBI chr10:13,105,435...13,182,664
Ensembl chr10:13,105,498...13,174,623 		JBrowse link
G Pmch pro-melanin-concentrating hormone increases expression EXP Calcifediol deficiency results in increased expression of PMCH mRNA CTD PMID:17293106 NCBI chr 7:22,511,934...22,513,250
Ensembl chr 7:22,511,934...22,513,250 		JBrowse link
G Ppm1b protein phosphatase, Mg2+/Mn2+ dependent, 1B decreases expression EXP Calcifediol deficiency results in decreased expression of PPM1B mRNA CTD PMID:17293106 NCBI chr 6:9,646,695...9,707,471
Ensembl chr 6:9,655,765...9,707,974 		JBrowse link
G Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha decreases expression EXP Calcifediol deficiency results in decreased expression of PPP3R1 mRNA CTD PMID:17293106 NCBI chr14:91,556,743...91,606,391
Ensembl chr14:91,604,121...91,606,907 		JBrowse link
G Psap prosaposin decreases expression EXP Calcifediol deficiency results in decreased expression of PSAP mRNA CTD PMID:17293106 NCBI chr20:28,214,229...28,240,501
Ensembl chr20:28,214,271...28,240,498 		JBrowse link
G Psat1 phosphoserine aminotransferase 1 decreases expression EXP Calcifediol deficiency results in decreased expression of PSAT1 mRNA CTD PMID:17293106 NCBI chr 1:213,196,709...213,218,564
Ensembl chr 1:213,196,709...213,218,682 		JBrowse link
G Psma2 proteasome 20S subunit alpha 2 increases expression EXP Calcifediol deficiency results in increased expression of PSMA2 mRNA CTD PMID:17293106 NCBI chr17:50,554,536...50,564,923
Ensembl chr17:50,551,924...50,564,938 		JBrowse link
G Pth parathyroid hormone multiple interactions EXP Calcifediol inhibits the reaction [Theophylline results in increased expression of PTH protein] CTD PMID:26851681 NCBI chr 1:167,508,121...167,511,530
Ensembl chr 1:167,508,598...167,511,530 		JBrowse link
G Pygb glycogen phosphorylase B decreases expression EXP Calcifediol deficiency results in decreased expression of PYGB mRNA CTD PMID:17293106 NCBI chr 3:139,611,724...139,658,521
Ensembl chr 3:139,611,749...139,663,553 		JBrowse link
G Rasgrp1 RAS guanyl releasing protein 1 decreases expression EXP Calcifediol deficiency results in decreased expression of RASGRP1 mRNA CTD PMID:17293106 NCBI chr 3:104,168,549...104,230,107
Ensembl chr 3:104,170,013...104,230,056 		JBrowse link
G Rasl11a RAS-like family 11 member A decreases expression EXP Calcifediol deficiency results in decreased expression of RASL11A mRNA CTD PMID:17293106 NCBI chr12:8,258,148...8,260,909
Ensembl chr12:8,258,159...8,262,576 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Calcifediol inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein] CTD PMID:34255241 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rhoa ras homolog family member A decreases expression EXP Calcifediol deficiency results in decreased expression of RHOA mRNA CTD PMID:17293106 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746 		JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions
increases expression		 ISO CYP27B1 protein promotes the reaction [Calcifediol results in increased expression of RUNX2 mRNA]; Ketoconazole inhibits the reaction [Calcifediol results in increased expression of RUNX2 mRNA] CTD PMID:21542014 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167 		JBrowse link
G Scd2 stearoyl-Coenzyme A desaturase 2 decreases expression EXP Calcifediol deficiency results in decreased expression of SCD2 mRNA CTD PMID:17293106 NCBI chr 1:243,169,171...243,182,231
Ensembl chr 1:243,169,236...243,182,232 		JBrowse link
G Sdc4 syndecan 4 increases expression EXP Calcifediol deficiency results in increased expression of SDC4 mRNA CTD PMID:17293106 NCBI chr 3:153,154,888...153,173,576
Ensembl chr 3:153,154,896...153,173,580 		JBrowse link
G Slc1a3 solute carrier family 1 member 3 decreases expression EXP Calcifediol deficiency results in decreased expression of SLC1A3 mRNA CTD PMID:17293106 NCBI chr 2:57,755,495...57,830,605
Ensembl chr 2:57,755,497...57,830,605 		JBrowse link
G Snrk SNF related kinase decreases expression EXP Calcifediol deficiency results in decreased expression of SNRK mRNA CTD PMID:17293106 NCBI chr 8:121,779,704...121,833,949
Ensembl chr 8:121,793,302...121,832,323 		JBrowse link
G Sod2 superoxide dismutase 2 decreases expression EXP Calcifediol deficiency results in decreased expression of SOD2 mRNA CTD PMID:17293106 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 decreases expression EXP Calcifediol deficiency results in decreased expression of SULT2A1 mRNA CTD PMID:17293106 NCBI chr 1:75,451,178...75,508,113
Ensembl chr 1:74,911,100...75,508,134 		JBrowse link
G Syt1 synaptotagmin 1 decreases expression EXP Calcifediol deficiency results in decreased expression of SYT1 mRNA CTD PMID:17293106 NCBI chr 7:43,813,204...44,358,020
Ensembl chr 7:43,815,785...44,357,803 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Calcifediol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Calcifediol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Calcifediol inhibits the reaction [TNF protein affects the expression of and results in increased phosphorylation of DNM1L protein]; Calcifediol inhibits the reaction [TNF protein promotes the reaction [BNIP3 protein binds to MAP1LC3B protein]]; Calcifediol inhibits the reaction [TNF protein results in increased expression of and affects the localization of BNIP3 protein]; Calcifediol inhibits the reaction [TNF protein results in increased expression of HIF1A protein]; Calcifediol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; Calcifediol inhibits the reaction [TNF protein results in increased expression of MAP1LC3B protein]; Calcifediol inhibits the reaction [TNF protein results in increased expression of MFF protein]; Calcifediol inhibits the reaction [TNF protein results in increased phosphorylation of AKT1 protein]; Calcifediol inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]; Calcifediol inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein]; Calcifediol inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]; Ketoconazole inhibits the reaction [Calcifediol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; Ketoconazole inhibits the reaction [Calcifediol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]
Calcifediol inhibits the reaction [TNF protein results in increased expression of BNIP3 protein]; Calcifediol inhibits the reaction [TNF protein results in increased expression of DNM1L protein]; Calcifediol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; Calcifediol inhibits the reaction [TNF protein results in increased expression of MFF protein]		 CTD PMID:11135059 PMID:34255241 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Ubqln1 ubiquilin 1 decreases expression EXP Calcifediol deficiency results in decreased expression of UBQLN1 mRNA CTD PMID:17293106 NCBI chr17:6,439,002...6,477,096
Ensembl chr17:6,439,002...6,477,090 		JBrowse link
G Vcp valosin-containing protein decreases expression EXP Calcifediol deficiency results in decreased expression of VCP mRNA CTD PMID:17293106 NCBI chr 5:57,210,167...57,229,571
Ensembl chr 5:57,210,168...57,229,571 		JBrowse link
G Vdac1 voltage-dependent anion channel 1 decreases expression EXP Calcifediol deficiency results in decreased expression of VDAC1 mRNA CTD PMID:17293106 NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640 		JBrowse link
G Vdr vitamin D receptor multiple interactions
increases activity		 ISO Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]; Calcifediol results in decreased degradation of and affects the localization of VDR protein; Ketoconazole inhibits the reaction [Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]]; VDR protein promotes the reaction [Calcifediol results in increased abundance of Lipids]
Calcifediol results in increased activity of VDR protein; Calcifediol results in increased activity of VDR protein mutant form		 CTD PMID:17997857 PMID:20079722 PMID:21291553 PMID:24792400 NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677 		JBrowse link
G Ybx1 Y box binding protein 1 increases expression EXP Calcifediol deficiency results in increased expression of YBX1 mRNA CTD PMID:17293106 NCBI chr 5:132,882,137...132,898,885
Ensembl chr 5:132,882,145...132,898,862 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    role 19854
      biological role 19852
        biochemical role 19582
          metabolite 19562
            calcidiol 102
              calcidiol 25-O-(beta-D-glucuronate) 0
              calcidiol 25-O-(beta-D-glucuronide) 0
              calcidiol 3-O-(beta-D-glucuronate) 0
              calcidiol 3-O-(beta-D-glucuronide) 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    p-block element atom 19849
                      carbon group element atom 19766
                        carbon atom 19785
                          organic molecular entity 19785
                            organic molecule 19737
                              organic cyclic compound 19526
                                organic polycyclic compound 17311
                                  steroid 14705
                                    hydroxy steroid 14469
                                      hydroxy seco-steroid 2703
                                        vitamin D 2698
                                          D3 vitamins 2643
                                            calciol 2645
                                              hydroxycalciol 2493
                                                calcidiol 102
                                                  calcidiol 25-O-(beta-D-glucuronate) 0
                                                  calcidiol 25-O-(beta-D-glucuronide) 0
                                                  calcidiol 3-O-(beta-D-glucuronate) 0
                                                  calcidiol 3-O-(beta-D-glucuronide) 0
paths to the root