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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:serine
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Accession:CHEBI:17822 term browser browse the term
Definition:An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Synonyms:related_synonym: 2-Amino-3-hydroxypropionic acid;   2-amino-3-hydroxypropanoic acid;   3-Hydroxyalanine;   Formula=C3H7NO3;   InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7);   InChIKey=MTCFGRXMJLQNBG-UHFFFAOYSA-N;   SMILES=NC(CO)C(O)=O;   Serin
 alt_id: CHEBI:15081;   CHEBI:26648;   CHEBI:9116
 xref: CAS:302-84-1;   Gmelin:26429;   KEGG:C00716;   KNApSAcK:C00001393;   Reaxys:1721402;   Wikipedia:Serine
 cyclic_relationship: is_conjugate_acid_of CHEBI:32845;   is_conjugate_base_of CHEBI:32846;   is_tautomer_of CHEBI:35243


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D-cycloserine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO Cycloserine inhibits the reaction [ABCB1 protein results in decreased susceptibility to Doxorubicin] CTD PMID:34915026 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO Cycloserine inhibits the reaction [resveratrol results in increased expression of DDIT3 protein] CTD PMID:24264887 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Egr1 early growth response 1 increases expression EXP Cycloserine results in increased expression of EGR1 protein CTD PMID:19144966 NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Cycloserine promotes the reaction [Clozapine results in increased expression of FOS mRNA] CTD PMID:12464447 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Homer1 homer scaffold protein 1 multiple interactions EXP Cycloserine inhibits the reaction [Clozapine results in increased expression of HOMER1 mRNA]; Cycloserine inhibits the reaction [Haloperidol results in increased expression of HOMER1 mRNA] CTD PMID:12464447 NCBI chr 2:24,542,777...24,645,715
Ensembl chr 2:24,543,093...24,644,785 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP Cycloserine inhibits the reaction [Dronabinol results in increased activity of MAPK1 protein] CTD PMID:11903061 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP Cycloserine inhibits the reaction [Dronabinol results in increased activity of MAPK3 protein] CTD PMID:11903061 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO Cycloserine inhibits the reaction [resveratrol results in increased cleavage of PARP1 protein] CTD PMID:24264887 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
goralatide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme increases expression
decreases expression
multiple interactions		 ISO goralatide results in increased expression of ACE mRNA
goralatide results in decreased expression of ACE mRNA
[BDKRB1 protein affects the activity of ACE protein] which affects the hydrolysis of goralatide; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of ACE mRNA]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of ACE protein]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in decreased expression of ACE2 mRNA]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in decreased expression of CDH1 protein]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in increased expression of ACE mRNA]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in increased expression of ACE protein]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in increased expression of COL3A1 protein]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in increased expression of VIM protein]]; goralatide affects the reaction [ACE2 protein affects the reaction [Silicon Dioxide results in increased expression of ACE mRNA]]; goralatide inhibits the reaction [AGT protein results in increased expression of ACE mRNA]; goralatide inhibits the reaction [AGT protein results in increased expression of ACE protein]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of ACE mRNA]		 CTD PMID:20096676 PMID:33007385 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131 		JBrowse link
G Ace2 angiotensin converting enzyme 2 multiple interactions ISO ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in decreased expression of MAS1 protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of ACE mRNA]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of ACE protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of AGT protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in decreased expression of ACE2 mRNA]]; goralatide affects the reaction [ACE2 protein affects the reaction [AGT protein results in decreased abundance of angiotensin I (1-7)]]; goralatide affects the reaction [ACE2 protein affects the reaction [Silicon Dioxide results in decreased expression of ACE2 mRNA]]; goralatide affects the reaction [ACE2 protein affects the reaction [Silicon Dioxide results in decreased expression of ACE2 protein]]; goralatide affects the reaction [ACE2 protein affects the reaction [Silicon Dioxide results in increased expression of ACE mRNA]]; goralatide affects the reaction [ACE2 protein affects the reaction [Silicon Dioxide results in increased expression of AGT protein]]; goralatide inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]; goralatide inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]; goralatide inhibits the reaction [Silicon Dioxide results in decreased expression of ACE2 mRNA]; goralatide inhibits the reaction [Silicon Dioxide results in decreased expression of ACE2 protein] CTD PMID:33007385 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO
EXP		 [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; goralatide inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]
[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]
goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]]; goralatide inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]		 CTD PMID:31181250 PMID:33007385 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Agt angiotensinogen multiple interactions ISO ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in decreased expression of MAS1 protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of ACE mRNA]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of ACE protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of AGT protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]]; goralatide affects the reaction [ACE2 protein affects the reaction [AGT protein results in decreased abundance of angiotensin I (1-7)]]; goralatide affects the reaction [ACE2 protein affects the reaction [Silicon Dioxide results in increased expression of AGT protein]]; goralatide inhibits the reaction [AGT protein results in decreased abundance of angiotensin I (1-7)]; goralatide inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]; goralatide inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]; goralatide inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]; goralatide inhibits the reaction [AGT protein results in decreased expression of MAS1 protein]; goralatide inhibits the reaction [AGT protein results in increased expression of ACE mRNA]; goralatide inhibits the reaction [AGT protein results in increased expression of ACE protein]; goralatide inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; goralatide inhibits the reaction [AGT protein results in increased expression of AGT protein]; goralatide inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]; goralatide inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]; goralatide inhibits the reaction [AGT protein results in increased expression of VIM protein]; goralatide inhibits the reaction [Silicon Dioxide results in decreased expression of AGT protein alternative form]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of AGT protein]
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in decreased expression of GLI3 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in decreased expression of PTCH1 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of GLI1 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of GLI2 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of SHH protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of SMO protein]; goralatide inhibits the reaction [AGT protein results in decreased expression of GLI3 protein]; goralatide inhibits the reaction [AGT protein results in decreased expression of PTCH1 protein]; goralatide inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; goralatide inhibits the reaction [AGT protein results in increased expression of GLI1 protein]; goralatide inhibits the reaction [AGT protein results in increased expression of GLI2 protein]; goralatide inhibits the reaction [AGT protein results in increased expression of SHH protein]; goralatide inhibits the reaction [AGT protein results in increased expression of SMO protein]		 CTD PMID:31181250 PMID:33007385 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions ISO ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]]; goralatide inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of AGTR1 protein] CTD PMID:33007385 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Bdkrb1 bradykinin receptor B1 affects abundance
multiple interactions		 ISO BDKRB1 protein affects the abundance of goralatide
[BDKRB1 protein affects the activity of ACE protein] which affects the hydrolysis of goralatide		 CTD PMID:20096676 NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747 		JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in decreased expression of CDH1 protein]]; goralatide inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]; goralatide inhibits the reaction [Silicon Dioxide results in decreased expression of CDH1 protein] CTD PMID:33007385 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions ISO ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in increased expression of COL3A1 protein]]; goralatide inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of COL3A1 protein] CTD PMID:33007385 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547 		JBrowse link
G Gli1 GLI family zinc finger 1 multiple interactions ISO
EXP		 [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of GLI1 protein]; goralatide inhibits the reaction [AGT protein results in increased expression of GLI1 protein]
[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of GLI1 protein]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of GLI1 protein]		 CTD PMID:31181250 NCBI chr 7:63,156,926...63,169,579
Ensembl chr 7:63,156,926...63,169,251 		JBrowse link
G Gli2 GLI family zinc finger 2 multiple interactions ISO
EXP		 [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of GLI2 protein]; goralatide inhibits the reaction [AGT protein results in increased expression of GLI2 protein]
[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of GLI2 protein]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of GLI2 protein]		 CTD PMID:31181250 NCBI chr13:29,946,882...30,163,589
Ensembl chr13:29,946,809...30,163,574 		JBrowse link
G Gli3 GLI family zinc finger 3 multiple interactions EXP
ISO		 [goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in decreased expression of GLI3 protein]; goralatide inhibits the reaction [Silicon Dioxide results in decreased expression of GLI3 protein]
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in decreased expression of GLI3 protein]; goralatide inhibits the reaction [AGT protein results in decreased expression of GLI3 protein]		 CTD PMID:31181250 NCBI chr17:49,438,567...49,709,712
Ensembl chr17:49,438,567...49,709,712 		JBrowse link
G Mas1 MAS1 proto-oncogene, G protein-coupled receptor multiple interactions ISO ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in decreased expression of MAS1 protein]]; goralatide inhibits the reaction [AGT protein results in decreased expression of MAS1 protein]; goralatide inhibits the reaction [Silicon Dioxide results in decreased expression of MAS1 protein] CTD PMID:33007385 NCBI chr 1:47,879,956...47,911,500
Ensembl chr 1:47,880,309...47,911,709 		JBrowse link
G Ptch1 patched 1 multiple interactions EXP
ISO		 [goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in decreased expression of PTCH1 protein]; goralatide inhibits the reaction [Silicon Dioxide results in decreased expression of PTCH1 protein]
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in decreased expression of PTCH1 protein]; goralatide inhibits the reaction [AGT protein results in decreased expression of PTCH1 protein]		 CTD PMID:31181250 NCBI chr17:1,542,705...1,607,730
Ensembl chr17:1,542,877...1,607,333 		JBrowse link
G Shh sonic hedgehog signaling molecule multiple interactions ISO
EXP		 [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of SHH protein]; goralatide inhibits the reaction [AGT protein results in increased expression of SHH protein]
[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of SHH protein]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of SHH protein]		 CTD PMID:31181250 NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170 		JBrowse link
G Smo smoothened, frizzled class receptor multiple interactions EXP
ISO		 [goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of SMO protein]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of SMO protein]
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of SMO protein]; goralatide inhibits the reaction [AGT protein results in increased expression of SMO protein]		 CTD PMID:31181250 NCBI chr 4:58,343,626...58,373,823
Ensembl chr 4:58,343,529...58,373,829 		JBrowse link
G Vim vimentin multiple interactions ISO goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in increased expression of VIM protein]]; goralatide inhibits the reaction [AGT protein results in increased expression of VIM protein]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of VIM protein] CTD PMID:33007385 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
L-serine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Angpt1 angiopoietin 1 multiple interactions EXP [LAMC1 protein modified form co-treated with ANGPT1 protein co-treated with Serine] inhibits the reaction [beta-N-methylamino-L-alanine affects the localization of TARDBP protein]; [LAMC1 protein modified form co-treated with ANGPT1 protein co-treated with Serine] inhibits the reaction [beta-N-methylamino-L-alanine results in decreased expression of SLC1A2 protein]; [LAMC1 protein modified form co-treated with ANGPT1 protein co-treated with Serine] inhibits the reaction [beta-N-methylamino-L-alanine results in increased expression of APP protein]; [LAMC1 protein modified form co-treated with ANGPT1 protein co-treated with Serine] inhibits the reaction [beta-N-methylamino-L-alanine results in increased expression of GSK3B protein]; [LAMC1 protein modified form co-treated with ANGPT1 protein co-treated with Serine] inhibits the reaction [beta-N-methylamino-L-alanine results in increased expression of IL6 protein]; [LAMC1 protein modified form co-treated with ANGPT1 protein co-treated with Serine] inhibits the reaction [beta-N-methylamino-L-alanine results in increased expression of MAP1LC3B protein]; [LAMC1 protein modified form co-treated with ANGPT1 protein co-treated with Serine] inhibits the reaction [beta-N-methylamino-L-alanine results in increased phosphorylation of MAPT protein] CTD PMID:30476904 NCBI chr 7:73,528,345...73,783,953
Ensembl chr 7:73,531,486...73,784,067 		JBrowse link
G App amyloid beta precursor protein multiple interactions EXP [LAMC1 protein modified form co-treated with ANGPT1 protein co-treated with Serine] inhibits the reaction [beta-N-methylamino-L-alanine results in increased expression of APP protein]; Serine inhibits the reaction [beta-N-methylamino-L-alanine results in increased expression of APP protein] CTD PMID:30476904 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Atf4 activating transcription factor 4 increases expression ISO Serine results in increased expression of ATF4 mRNA CTD PMID:29098664 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Atf6 activating transcription factor 6 increases expression ISO Serine results in increased expression of ATF6 mRNA CTD PMID:29098664 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177 		JBrowse link
G Atf6b activating transcription factor 6 beta increases expression ISO Serine results in increased expression of ATF6B mRNA CTD PMID:29098664 NCBI chr20:4,090,921...4,098,920
Ensembl chr20:4,090,921...4,098,894 		JBrowse link
G Atxn3 ataxin 3 increases expression ISO Serine results in increased expression of ATXN3 mRNA CTD PMID:29098664 NCBI chr 6:121,072,228...121,107,902
Ensembl chr 6:121,074,448...121,107,902 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Serine results in increased expression of BAX mRNA CTD PMID:29098664 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Calr calreticulin increases expression ISO Serine results in increased expression of CALR mRNA CTD PMID:29098664 NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414 		JBrowse link
G Canx calnexin increases expression ISO Serine results in increased expression of CANX mRNA CTD PMID:29098664 NCBI chr10:34,623,865...34,656,866
Ensembl chr10:34,625,191...34,656,821 		JBrowse link
G Cct4 chaperonin containing TCP1 subunit 4 increases expression ISO Serine results in increased expression of CCT4 mRNA CTD PMID:29098664 NCBI chr14:96,991,853...97,004,732
Ensembl chr14:96,991,859...97,005,267 		JBrowse link
G Cct7 chaperonin containing TCP1 subunit 7 increases expression ISO Serine results in increased expression of CCT7 mRNA CTD PMID:29098664 NCBI chr 4:117,989,232...118,006,478
Ensembl chr 4:117,989,232...118,006,580 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta decreases expression ISO Serine results in decreased expression of CEBPB mRNA CTD PMID:29098664 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473 		JBrowse link
G Cs citrate synthase decreases activity EXP Serine analog results in decreased activity of CS protein CTD PMID:19733154 NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421 		JBrowse link
G Derl2 derlin 2 increases expression ISO Serine results in increased expression of DERL2 mRNA CTD PMID:29098664 NCBI chr10:55,727,764...55,739,442
Ensembl chr10:55,727,643...55,739,518 		JBrowse link
G Dnajb2 DnaJ heat shock protein family (Hsp40) member B2 increases expression ISO Serine results in increased expression of DNAJB2 mRNA CTD PMID:29098664 NCBI chr 9:76,731,060...76,739,278
Ensembl chr 9:76,731,065...76,739,277 		JBrowse link
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 increases expression ISO Serine results in increased expression of DNAJB9 mRNA CTD PMID:29098664 NCBI chr 6:61,270,385...61,276,795
Ensembl chr 6:61,269,913...61,275,063 		JBrowse link
G Dnajc3 DnaJ heat shock protein family (Hsp40) member C3 increases expression ISO Serine results in increased expression of DNAJC3 mRNA CTD PMID:29098664 NCBI chr15:96,025,605...96,068,585
Ensembl chr15:96,025,624...96,065,181 		JBrowse link
G Dnajc4 DnaJ heat shock protein family (Hsp40) member C4 increases expression ISO Serine results in increased expression of DNAJC4 mRNA CTD PMID:29098664 NCBI chr 1:204,178,189...204,182,412
Ensembl chr 1:204,178,191...204,182,387 		JBrowse link
G Edem1 ER degradation enhancing alpha-mannosidase like protein 1 increases expression ISO Serine results in increased expression of EDEM1 mRNA CTD PMID:29098664 NCBI chr 4:141,797,631...141,829,717
Ensembl chr 4:141,797,701...141,829,717 		JBrowse link
G Eif2a eukaryotic translation initiation factor 2A increases expression ISO Serine results in increased expression of EIF2A mRNA CTD PMID:29098664 NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068 		JBrowse link
G Erp44 endoplasmic reticulum protein 44 increases expression ISO Serine results in increased expression of ERP44 mRNA CTD PMID:29098664 NCBI chr 5:62,516,550...62,610,762
Ensembl chr 5:62,516,551...62,610,761 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP [LAMC1 protein modified form co-treated with ANGPT1 protein co-treated with Serine] inhibits the reaction [beta-N-methylamino-L-alanine results in increased expression of GSK3B protein]; Serine inhibits the reaction [beta-N-methylamino-L-alanine results in increased expression of GSK3B protein] CTD PMID:30476904 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 increases expression ISO Serine results in increased expression of HERPUD1 mRNA CTD PMID:29098664 NCBI chr19:10,598,411...10,609,002
Ensembl chr19:10,598,417...10,618,424 		JBrowse link
G Hsf1 heat shock transcription factor 1 increases activity ISO Serine results in increased activity of HSF1 protein CTD PMID:34170685 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011 		JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B decreases expression ISO Serine results in decreased expression of HSPA1B mRNA CTD PMID:29098664 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240 		JBrowse link
G Hspa1l heat shock protein family A (Hsp70) member 1 like increases expression ISO Serine results in increased expression of HSPA1L mRNA CTD PMID:29098664 NCBI chr20:3,848,843...3,855,571
Ensembl chr20:3,848,843...3,855,571 		JBrowse link
G Htra4 HtrA serine peptidase 4 decreases expression ISO Serine results in decreased expression of HTRA4 mRNA CTD PMID:29098664 NCBI chr16:67,001,605...67,015,074
Ensembl chr16:67,001,605...67,015,074 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP [LAMC1 protein modified form co-treated with ANGPT1 protein co-treated with Serine] inhibits the reaction [beta-N-methylamino-L-alanine results in increased expression of IL6 protein]; Serine inhibits the reaction [beta-N-methylamino-L-alanine results in increased expression of IL6 protein] CTD PMID:30476904 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Lamc1 laminin subunit gamma 1 multiple interactions EXP [LAMC1 protein modified form co-treated with ANGPT1 protein co-treated with Serine] inhibits the reaction [beta-N-methylamino-L-alanine affects the localization of TARDBP protein]; [LAMC1 protein modified form co-treated with ANGPT1 protein co-treated with Serine] inhibits the reaction [beta-N-methylamino-L-alanine results in decreased expression of SLC1A2 protein]; [LAMC1 protein modified form co-treated with ANGPT1 protein co-treated with Serine] inhibits the reaction [beta-N-methylamino-L-alanine results in increased expression of APP protein]; [LAMC1 protein modified form co-treated with ANGPT1 protein co-treated with Serine] inhibits the reaction [beta-N-methylamino-L-alanine results in increased expression of GSK3B protein]; [LAMC1 protein modified form co-treated with ANGPT1 protein co-treated with Serine] inhibits the reaction [beta-N-methylamino-L-alanine results in increased expression of IL6 protein]; [LAMC1 protein modified form co-treated with ANGPT1 protein co-treated with Serine] inhibits the reaction [beta-N-methylamino-L-alanine results in increased expression of MAP1LC3B protein]; [LAMC1 protein modified form co-treated with ANGPT1 protein co-treated with Serine] inhibits the reaction [beta-N-methylamino-L-alanine results in increased phosphorylation of MAPT protein] CTD PMID:30476904 NCBI chr13:65,374,372...65,501,492
Ensembl chr13:65,374,372...65,501,492 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions EXP [LAMC1 protein modified form co-treated with ANGPT1 protein co-treated with Serine] inhibits the reaction [beta-N-methylamino-L-alanine results in increased expression of MAP1LC3B protein]; Serine inhibits the reaction [beta-N-methylamino-L-alanine results in increased expression of MAP1LC3B protein] CTD PMID:30476904 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
Ensembl chr16:49,665,791...49,677,690 		JBrowse link
G Mapk10 mitogen activated protein kinase 10 decreases expression ISO Serine results in decreased expression of MAPK10 mRNA CTD PMID:29098664 NCBI chr14:6,497,662...6,790,109
Ensembl chr14:6,497,707...6,786,201 		JBrowse link
G Mapt microtubule-associated protein tau multiple interactions EXP [LAMC1 protein modified form co-treated with ANGPT1 protein co-treated with Serine] inhibits the reaction [beta-N-methylamino-L-alanine results in increased phosphorylation of MAPT protein]; Serine inhibits the reaction [beta-N-methylamino-L-alanine results in increased phosphorylation of MAPT protein] CTD PMID:30476904 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129 		JBrowse link
G P4hb prolyl 4-hydroxylase subunit beta increases expression ISO Serine results in increased expression of P4HB protein CTD PMID:28975502 NCBI chr10:105,836,972...105,848,583
Ensembl chr10:105,836,982...105,848,500 		JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A decreases expression ISO Serine results in decreased expression of PPP1R15A mRNA CTD PMID:29098664 NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171 		JBrowse link
G Slc1a2 solute carrier family 1 member 2 multiple interactions EXP [LAMC1 protein modified form co-treated with ANGPT1 protein co-treated with Serine] inhibits the reaction [beta-N-methylamino-L-alanine results in decreased expression of SLC1A2 protein]; Serine inhibits the reaction [beta-N-methylamino-L-alanine results in decreased expression of SLC1A2 protein] CTD PMID:30476904 NCBI chr 3:89,005,129...89,135,469
Ensembl chr 3:89,005,129...89,126,498 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression ISO Serine results in decreased expression of SREBF1 mRNA CTD PMID:29098664 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Srr serine racemase multiple interactions EXP SRR protein results in increased abundance of and results in increased secretion of Serine analog CTD PMID:27387750 NCBI chr10:59,769,563...59,786,688
Ensembl chr10:59,769,571...59,787,011 		JBrowse link
G Tardbp TAR DNA binding protein multiple interactions EXP [LAMC1 protein modified form co-treated with ANGPT1 protein co-treated with Serine] inhibits the reaction [beta-N-methylamino-L-alanine affects the localization of TARDBP protein]; Serine inhibits the reaction [beta-N-methylamino-L-alanine affects the localization of TARDBP protein] CTD PMID:30476904 NCBI chr 5:159,050,518...159,062,218
Ensembl chr 5:159,051,799...159,062,055 		JBrowse link
G Ube2g2 ubiquitin-conjugating enzyme E2G 2 decreases expression ISO Serine results in decreased expression of UBE2G2 mRNA CTD PMID:29098664 NCBI chr20:10,983,734...11,005,468
Ensembl chr20:10,983,742...11,005,447 		JBrowse link
G Vcp valosin-containing protein decreases expression ISO Serine results in decreased expression of VCP mRNA CTD PMID:29098664 NCBI chr 5:57,210,167...57,229,571
Ensembl chr 5:57,210,168...57,229,571 		JBrowse link
O-phosphoserine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mapt microtubule-associated protein tau decreases abundance
multiple interactions		 ISO MAPT protein mutant form results in decreased abundance of Phosphoserine
PF-06840003 inhibits the reaction [MAPT protein mutant form results in decreased abundance of Phosphoserine]		 CTD PMID:39172838 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129 		JBrowse link
Phe-Ser term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc15a1 solute carrier family 15 member 1 affects binding ISO phenylalanylserine analog binds to SLC15A1 protein CTD PMID:21147219 NCBI chr15:98,537,641...98,582,544
Ensembl chr15:98,537,641...98,582,545 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      application 19695
        fuel 11357
          methanol 3972
            hydroxymethyl group 65
              serine 65
                3-oxoalanine + 0
                D-serine + 0
                L-serine + 57
                N-(2,4-dinitrophenyl)serine 0
                gougerotin 0
                serine derivative + 9
                serine residue + 0
                serino group + 0
                seryl group + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    main group molecular entity 19817
                      s-block molecular entity 19653
                        hydrogen molecular entity 19634
                          hydrides 19144
                            inorganic hydride 18161
                              pnictogen hydride 18151
                                nitrogen hydride 18064
                                  azane 17872
                                    ammonia 17871
                                      organic amino compound 17871
                                        amino acid 16060
                                          alpha-amino acid 13932
                                            serine 65
                                              3-oxoalanine + 0
                                              D-serine + 0
                                              L-serine + 57
                                              N-(2,4-dinitrophenyl)serine 0
                                              gougerotin 0
                                              serine derivative + 9
                                              serine residue + 0
                                              serino group + 0
                                              seryl group + 0
paths to the root