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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:oncrasin-1
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Accession:CHEBI:178196 term browser browse the term
Definition:A member of the class of indoles that is 1H-indole substituted by 4-chlorobenzyl and formyl groups at positions 1 and 3, respectively. It is an anti-cancer agent that is active against lung cancer cells with K-Ras mutations.
Synonyms:exact_synonym: 1-(4-chlorobenzyl)-1H-indole-3-carbaldehyde
 related_synonym: 1-(p-chlorobenzyl)-1H-indole-3-carbaldehyde;   1-[(4-chlorophenyl)methyl]-1H-indole-3-carbaldehyde;   Formula=C16H12ClNO;   InChI=1S/C16H12ClNO/c17-14-7-5-12(6-8-14)9-18-10-13(11-19)15-3-1-2-4-16(15)18/h1-8,10-11H,9H2;   InChIKey=ZDRQMXCSSAPUMM-UHFFFAOYSA-N;   ONC-1;   SMILES=[H]C(=O)C1=CN(CC2=CC=C(Cl)C=C2)C2=CC=CC=C12
 xref: CAS:75629-57-1;   Chemspider:761753
 xref_mesh: MESH:C532252
 xref: PMID:18794128;   PMID:19208825;   PMID:21443218;   PMID:22174819;   PMID:25874341;   PMID:32019870;   PMID:32727562;   PMID:33169204;   Patent:US2009286847


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oncrasin-1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kras KRAS proto-oncogene, GTPase increases response to substance ISO KRAS protein mutant form results in increased susceptibility to oncrasin-1 CTD PMID:21443218 NCBI chr 4:178,185,418...178,218,484 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      biological role 19848
        biochemical role 19556
          apoptosis inducer 13663
            oncrasin-1 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      carbon group element atom 19757
                        carbon atom 19754
                          organic molecular entity 19754
                            heteroorganic entity 19512
                              organochalcogen compound 19275
                                organooxygen compound 19191
                                  carbon oxoacid 18658
                                    carboxylic acid 18655
                                      carboacyl group 17699
                                        univalent carboacyl group 17699
                                          formyl group 9051
                                            aldehyde 9051
                                              arenecarbaldehyde 139
                                                oncrasin-1 1
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