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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:4-Hydroxyclonidine
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Accession:CHEBI:178136 term browser browse the term
Synonyms:exact_synonym: 3,5-dichloro-4-(4,5-dihydro-1H-imidazol-2-ylamino)phenol
 related_synonym: Formula=C9H9Cl2N3O;   InChI=1S/C9H9Cl2N3O/c10-6-3-5(15)4-7(11)8(6)14-9-12-1-2-13-9/h3-4,15H,1-2H2,(H2,12,13,14);   InChIKey=NTWBRPXHGAXREI-UHFFFAOYSA-N;   SMILES=ClC1=C(NC=2NCCN2)C(Cl)=CC(O)=C1
 xref: CAS:57101-48-1;   Chemspider:83644;   HMDB:HMDB0060555
 xref_mesh: MESH:C060689


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4-Hydroxyclonidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions ISO [[CYP2D6 gene polymorphism results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Clonidine] which results in decreased chemical synthesis of 4-hydroxyclonidine; [CYP2D6 protein results in increased metabolism of Clonidine] which results in increased chemical synthesis of 4-hydroxyclonidine CTD PMID:31585114 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19898
    chemical entity 19896
      molecular entity 19896
        polyatomic entity 19848
          heteroatomic molecular entity 19806
            halide 18685
              organohalogen compound 18549
                organochlorine compound 18320
                  chlorobenzenes 15061
                    dichlorobenzene 11560
                      4-Hydroxyclonidine 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19774
                        carbon group molecular entity 19774
                          organic molecular entity 19771
                            organic molecule 19724
                              organic cyclic compound 19515
                                organic aromatic compound 19382
                                  benzenoid aromatic compound 18028
                                    benzenes 17893
                                      chlorobenzenes 15061
                                        dichlorobenzene 11560
                                          4-Hydroxyclonidine 1
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