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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cystathionine
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Accession:CHEBI:17755 term browser browse the term
Definition:A modified amino acid generated by enzymic means from homocysteine and serine.
Synonyms:exact_synonym: 2-amino-4-[(2-amino-2-carboxyethyl)sulfanyl]butanoic acid;   S-(2-amino-2-carboxyethyl)homocysteine
 related_synonym: DL-Cystathionine;   Formula=C7H14N2O4S;   InChI=1S/C7H14N2O4S/c8-4(6(10)11)1-2-14-3-5(9)7(12)13/h4-5H,1-3,8-9H2,(H,10,11)(H,12,13);   InChIKey=ILRYLPWNYFXEMH-UHFFFAOYSA-N;   SMILES=NC(CCSCC(N)C(O)=O)C(O)=O;   cystathione
 alt_id: CHEBI:14059;   CHEBI:4048
 xref: CAS:535-34-2;   KEGG:C00542;   PMID:12907234;   PMID:15033753;   PMID:22212096;   PMID:22264337;   Reaxys:2416815



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L-cystathionine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO BAX protein inhibits the reaction [Cystathionine inhibits the reaction [Homocysteine results in increased activity of CASP3 protein]]; BTSA1 compound inhibits the reaction [Cystathionine inhibits the reaction [Homocysteine affects the localization of BAX protein]]; Cystathionine inhibits the reaction [Homocysteine affects the localization of BAX protein]; Cystathionine inhibits the reaction [Homocysteine results in increased expression of and affects the localization of BAX protein] CTD PMID:31885769 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Casp3 caspase 3 multiple interactions ISO BAX protein inhibits the reaction [Cystathionine inhibits the reaction [Homocysteine results in increased activity of CASP3 protein]]; BTSA1 compound inhibits the reaction [Cystathionine inhibits the reaction [Homocysteine results in increased cleavage of CASP3 protein]]; Cystathionine inhibits the reaction [Homocysteine results in increased activity of and results in increased cleavage of CASP3 protein] CTD PMID:31885769 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 multiple interactions ISO BTSA1 compound inhibits the reaction [Cystathionine inhibits the reaction [Homocysteine results in increased activity of CASP9 protein]]; Cystathionine inhibits the reaction [Homocysteine results in increased activity of CASP9 protein] CTD PMID:31885769 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ins2 insulin 2 multiple interactions ISO [1-Methyl-3-isobutylxanthine co-treated with butylbenzyl phthalate co-treated with INS protein] results in increased abundance of Cystathionine analog CTD PMID:26820058 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Kyat1 kynurenine aminotransferase 1 increases amination ISO KYAT1 protein results in increased amination of Cystathionine CTD PMID:22093698 NCBI chr 3:13,459,598...13,493,308
Ensembl chr 3:13,459,591...13,493,355
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions ISO Cystathionine inhibits the reaction [Formaldehyde results in increased expression of MMP1 protein] CTD PMID:27664576 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19878
    role 19848
      biological role 19846
        biochemical role 19550
          metabolite 19538
            cystathionine 6
              L-cystathionine 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19878
    subatomic particle 19876
      composite particle 19876
        hadron 19876
          baryon 19876
            nucleon 19876
              atomic nucleus 19876
                atom 19876
                  main group element atom 19815
                    main group molecular entity 19815
                      s-block molecular entity 19650
                        hydrogen molecular entity 19631
                          hydrides 19137
                            inorganic hydride 18153
                              pnictogen hydride 18143
                                nitrogen hydride 18056
                                  azane 17862
                                    ammonia 17861
                                      organic amino compound 17861
                                        amino acid 16049
                                          non-proteinogenic amino acid 3991
                                            non-proteinogenic alpha-amino acid 3796
                                              homocysteines 415
                                                cystathionines 6
                                                  cystathionine 6
                                                    L-cystathionine 6
paths to the root