Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:thymidine
go back to main search page
Accession:CHEBI:17748 term browser browse the term
Definition:A pyrimidine 2'-deoxyribonucleoside having thymine as the nucleobase.
Synonyms:related_synonym: 1-(2-deoxy-beta-D-erythro-pentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione;   2'-deoxy-5-methyluridine;   2'-deoxythymidine;   2'-thymidine;   5-methyl-2'-deoxyuridine;   Deoxythymidine;   Formula=C10H14N2O5;   InChI=1S/C10H14N2O5/c1-5-3-12(10(16)11-9(5)15)8-2-6(14)7(4-13)17-8/h3,6-8,13-14H,2,4H2,1H3,(H,11,15,16)/t6-,7+,8+/m0/s1;   InChIKey=IQFYYKKMVGJFEH-XLPZGREQSA-N;   SMILES=Cc1cn([C@H]2C[C@H](O)[C@@H](CO)O2)c(=O)[nH]c1=O;   T;   dThd;   thymine 2'-deoxyriboside
 alt_id: CHEBI:15244;   CHEBI:19273;   CHEBI:45782;   CHEBI:45834;   CHEBI:45917;   CHEBI:9579
 xref: Beilstein:89285;   CAS:50-89-5;   DrugBank:DB04485;   Gmelin:282610;   HMDB:HMDB0000273;   KEGG:C00214;   KNApSAcK:C00019698
 xref_mesh: MESH:D013936
 xref: MetaCyc:THYMIDINE;   PDBeChem:THM;   PMID:22770225;   PMID:2559771;   Reaxys:89285;   Wikipedia:Thymidine
 cyclic_relationship: is_enantiomer_of CHEBI:63624



show annotations for term's descendants           Sort by:
thymidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle increases expression
multiple interactions
ISO Thymidine results in increased expression of ACTA2 mRNA
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Thymidine results in increased expression of ACTA2 mRNA]
CTD PMID:31170432 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Alpi alkaline phosphatase, intestinal multiple interactions ISO Thymidine promotes the reaction [Methotrexate results in increased activity of ALPI protein] CTD PMID:16598758 NCBI chr 9:87,773,411...87,776,877
Ensembl chr 9:87,773,411...87,776,877
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Thymidine inhibits the reaction [Adenosine results in increased localization of BAX protein] CTD PMID:11570579 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO Thymidine inhibits the reaction [Adenosine results in increased activity of CASP3 protein]
Thymidine results in increased activity of CASP3 protein
CTD PMID:11570579 PMID:16419169 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 multiple interactions ISO Thymidine inhibits the reaction [Adenosine results in increased activity of CASP9 protein] CTD PMID:11570579 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Csf1 colony stimulating factor 1 increases uptake ISO CSF1 protein results in increased uptake of Thymidine CTD PMID:8193360 NCBI chr 2:195,377,215...195,396,608
Ensembl chr 2:195,377,215...195,411,704
JBrowse link
G Csf2 colony stimulating factor 2 increases uptake ISO CSF2 protein results in increased uptake of Thymidine CTD PMID:8193360 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Edn1 endothelin 1 increases uptake ISO EDN1 protein results in increased uptake of Thymidine CTD PMID:10100047 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Faslg Fas ligand increases expression ISO Thymidine results in increased expression of FASLG protein CTD PMID:16419169 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO Thymidine inhibits the reaction [PIF1 protein inhibits the reaction [Gemcitabine results in increased expression of H2AX protein]] CTD PMID:37183367 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO [Thymidine co-treated with TYMP co-treated with Oxygen deficiency] results in increased expression of HIF1A protein CTD PMID:15841086 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO [Thymidine co-treated with TYMP protein] results in increased expression of HMOX1 protein; [TYMP protein co-treated with Thymidine] results in increased expression of HMOX1 protein; Acetylcysteine inhibits the reaction [[TYMP protein co-treated with Thymidine] results in increased expression of HMOX1 protein]; Thymine inhibits the reaction [[TYMP protein co-treated with Thymidine] results in increased expression of HMOX1 protein] CTD PMID:11103787 PMID:15841086 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Igf1 insulin-like growth factor 1 decreases uptake
multiple interactions
ISO IGF1 protein results in decreased uptake of Thymidine
[Tetrachlorodibenzodioxin co-treated with Estradiol] inhibits the reaction [IGF1 protein results in increased uptake of Thymidine]; Tetrachlorodibenzodioxin inhibits the reaction [IGF1 protein results in decreased uptake of Thymidine]
CTD PMID:1332906 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions ISO [Thymidine co-treated with TYMP protein] results in increased expression of MMP1 protein; Thymine inhibits the reaction [[Thymidine co-treated with TYMP protein] results in increased expression of MMP1 protein] CTD PMID:11103787 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase multiple interactions ISO [Thymidine co-treated with Hypoxanthine co-treated with 5,6,7,8-tetrahydrofolic acid] inhibits the reaction [Methotrexate results in decreased expression of MTR protein]; [Thymidine co-treated with Hypoxanthine] inhibits the reaction [Methotrexate results in decreased expression of MTR protein] CTD PMID:16598758 NCBI chr17:58,219,998...58,308,560
Ensembl chr17:58,220,071...58,304,822
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO Thymidine inhibits the reaction [Adenosine results in decreased expression of MYC protein] CTD PMID:9808420 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Pif1 PIF1 5'-to-3' DNA helicase multiple interactions ISO Thymidine inhibits the reaction [PIF1 protein inhibits the reaction [Gemcitabine results in increased expression of H2AX protein]] CTD PMID:37183367 NCBI chr 8:66,110,641...66,120,202
Ensembl chr 8:66,111,072...66,120,200
JBrowse link
G Slc28a1 solute carrier family 28 member 1 multiple interactions ISO Thymidine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine] CTD PMID:9124315 NCBI chr 1:135,079,375...135,122,791
Ensembl chr 1:135,081,385...135,122,464
JBrowse link
G Slc29a1 solute carrier family 29 member 1 multiple interactions ISO
EXP
Thymidine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine] CTD PMID:9353301 PMID:11085929 NCBI chr 9:15,399,661...15,414,203
Ensembl chr 9:15,399,612...15,414,203
JBrowse link
G Slc29a2 solute carrier family 29 member 2 multiple interactions ISO Thymidine inhibits the reaction [SLC29A2 protein results in increased uptake of Uridine] CTD PMID:11085929 NCBI chr 1:202,327,641...202,335,185
Ensembl chr 1:202,327,354...202,335,171
JBrowse link
G Tymp thymidine phosphorylase multiple interactions
increases phosphorylation
ISO [Thymidine co-treated with TYMP co-treated with Oxygen deficiency] results in increased expression of HIF1A protein; [Thymidine co-treated with TYMP protein] results in increased expression of HMOX1 protein; [Thymidine co-treated with TYMP protein] results in increased expression of MMP1 protein; [Thymidine co-treated with TYMP protein] results in increased secretion of CXCL8 protein; [TYMP protein co-treated with Thymidine] results in increased expression of HMOX1 protein; Acetylcysteine inhibits the reaction [[TYMP protein co-treated with Thymidine] results in increased expression of HMOX1 protein]; Thymine inhibits the reaction [[Thymidine co-treated with TYMP protein] results in increased expression of MMP1 protein]; Thymine inhibits the reaction [[Thymidine co-treated with TYMP protein] results in increased secretion of CXCL8 protein]; Thymine inhibits the reaction [[TYMP protein co-treated with Thymidine] results in increased expression of HMOX1 protein]
TYMP protein results in increased phosphorylation of Thymidine
CTD PMID:11103787 PMID:15841086 NCBI chr 7:120,438,768...120,444,088
Ensembl chr 7:120,438,770...120,443,874
Ensembl chr 7:120,438,770...120,443,874
JBrowse link
G Tyms thymidylate synthetase multiple interactions ISO Thymidine inhibits the reaction [Fluorouracil results in decreased expression of TYMS] CTD PMID:9050858 NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536
JBrowse link
dTDP term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gale UDP-galactose-4-epimerase affects binding ISO thymidine 5'-diphosphate binds to GALE protein CTD PMID:25526675 NCBI chr 5:148,193,886...148,198,392
Ensembl chr 5:148,194,791...148,198,388
JBrowse link
G Uxs1 UDP-glucuronate decarboxylase 1 multiple interactions ISO [thymidine 5'-diphosphate co-treated with NAD] binds to UXS1 protein CTD PMID:25526675 NCBI chr 9:653,740...731,121
Ensembl chr 9:653,659...756,334
JBrowse link
dTMP term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 multiple interactions
increases abundance
ISO Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Thymidine Monophosphate] CTD PMID:27469509 NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025
JBrowse link
G Tyms thymidylate synthetase multiple interactions ISO [Fluorouracil results in decreased activity of TYMS protein] which results in decreased abundance of Thymidine Monophosphate CTD PMID:29258758 NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19922
    role 19894
      biological role 19864
        biochemical role 19596
          metabolite 19558
            thymidine 25
              5'-O-\{[3-(benzoyloxy)-3-oxopropyl]carbamoyl\}thymidine 0
              5,6-dihydrothymidine 0
              alpha-tritiated thymidine 0
              polyoxin + 0
              thymidine phosphate + 4
              tritiated thymidine + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19922
    subatomic particle 19892
      composite particle 19892
        hadron 19920
          baryon 19892
            nucleon 19920
              atomic nucleus 19892
                atom 19892
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19805
                        carbon atom 19802
                          organic molecular entity 19775
                            heteroorganic entity 19556
                              organochalcogen compound 19315
                                organooxygen compound 19205
                                  carbohydrates and carbohydrate derivatives 15294
                                    carbohydrate 15294
                                      carbohydrate derivative 14304
                                        glycosyl compound 13062
                                          N-glycosyl compound 5827
                                            nucleoside 5685
                                              deoxyribonucleoside 2889
                                                2'-deoxyribonucleoside 2248
                                                  pyrimidine 2'-deoxyribonucleoside 354
                                                    thymidine 25
                                                      5'-O-\{[3-(benzoyloxy)-3-oxopropyl]carbamoyl\}thymidine 0
                                                      5,6-dihydrothymidine 0
                                                      alpha-tritiated thymidine 0
                                                      polyoxin + 0
                                                      thymidine phosphate + 4
                                                      tritiated thymidine + 0
paths to the root