organic tetracyclic compound - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	organic tetracyclic compound	go back to main search page
Accession:	CHEBI:177333	browse the term
Synonyms:	related_synonym:	organic tetracyclic compounds

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Rat (328 ) Mouse (330 ) Human (332 ) Chinchilla (0 ) Bonobo (0 ) Dog (0 ) Squirrel (0 ) Pig (2 ) Green Monkey (0) Naked Mole-rat (0 ) All
Genes (328)

(20R)-protopanaxadiol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetylcholinesterase

multiple interactions

ISO

protopanaxadiol inhibits the reaction [Scopolamine results in increased activity of ACHE protein]

NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410

G

Bcl2-like 1

increases expression

ISO

protopanaxadiol results in increased expression of BCL2L1 mRNA

NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907

G

baculoviral IAP repeat-containing 5

affects expression

ISO

protopanaxadiol affects the expression of BIRC5 protein

NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,572,080...103,582,155

G

caspase 3

increases expression
affects cleavage

ISO

protopanaxadiol results in increased expression of CASP3 mRNA
protopanaxadiol affects the cleavage of CASP3 protein

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 9

increases expression
affects expression

ISO

protopanaxadiol results in increased expression of CASP9 mRNA
protopanaxadiol affects the expression of CASP9 protein

Ensembl chr 5:159,391,188...159,409,648

G

cyclin A2

increases expression

ISO

protopanaxadiol results in increased expression of CCNA2 mRNA

NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:121,355,363...121,361,701

G

cyclin B1

increases expression

ISO

protopanaxadiol results in increased expression of CCNB1 mRNA

NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225

G

cyclin D1

increases expression

ISO

protopanaxadiol results in increased expression of CCND1 mRNA

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810

G

cell division cycle 25A

multiple interactions
increases expression

ISO

protopanaxadiol results in increased expression of and results in decreased phosphorylation of CDC25A protein
protopanaxadiol results in increased expression of CDC25A mRNA

NCBI chr 8:118,742,824...118,761,190
Ensembl chr 8:118,742,426...118,761,188

G

cell division cycle 25C

increases expression
multiple interactions

ISO

protopanaxadiol results in increased expression of CDC25C mRNA
protopanaxadiol affects the expression of and affects the phosphorylation of CDC25C protein

NCBI chr18:26,608,483...26,630,292
Ensembl chr18:26,609,959...26,630,292

G

cyclin-dependent kinase 1

increases expression

ISO

protopanaxadiol results in increased expression of CDK1 mRNA

NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,265,289...19,280,455

G

cyclin dependent kinase 2

increases expression

ISO

protopanaxadiol results in increased expression of CDK2 mRNA

NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,714,392...1,721,878

G

cyclin-dependent kinase 4

increases expression

ISO

protopanaxadiol results in increased expression of CDK4 mRNA; protopanaxadiol results in increased expression of CDK4 protein

NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:64,771,147...64,775,163

G

choline O-acetyltransferase

multiple interactions

ISO

protopanaxadiol inhibits the reaction [Scopolamine results in decreased activity of CHAT protein]

NCBI chr16:7,663,665...7,723,416
Ensembl chr16:7,663,665...7,723,416

G

epidermal growth factor receptor

multiple interactions
decreases activity

ISO

protopanaxadiol results in decreased expression of and results in increased phosphorylation of EGFR protein
protopanaxadiol results in decreased activity of EGFR protein

NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358

G

early growth response 1

multiple interactions

ISO

protopanaxadiol inhibits the reaction [Scopolamine results in decreased expression of EGR1 protein]

NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,736,838...26,740,843

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

ISO

protopanaxadiol inhibits the reaction [Scopolamine results in decreased expression of FOS protein]

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions

ISO

protopanaxadiol inhibits the reaction [Scopolamine results in decreased expression of JUN protein]

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285

G

mitogen activated protein kinase kinase 1

increases expression

ISO

protopanaxadiol results in increased expression of MAP2K1 mRNA

NCBI chr 8:73,578,747...73,650,184
Ensembl chr 8:73,578,752...73,650,184

G

mitogen activated protein kinase 1

decreases phosphorylation

ISO

protopanaxadiol results in decreased phosphorylation of MAPK1 protein

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

decreases phosphorylation

ISO

protopanaxadiol results in decreased phosphorylation of MAPK3 protein

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

poly (ADP-ribose) polymerase 1

increases expression

ISO

protopanaxadiol results in increased expression of PARP1 mRNA

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

Raf-1 proto-oncogene, serine/threonine kinase

increases phosphorylation

ISO

protopanaxadiol results in increased phosphorylation of RAF1 protein

NCBI chr 4:150,352,158...150,412,813
Ensembl chr 4:150,352,160...150,412,813

G

ribosomal protein S6 kinase A1

increases expression

ISO

protopanaxadiol results in increased expression of RPS6KA1 mRNA

NCBI chr 5:151,362,819...151,402,064
Ensembl chr 5:151,362,819...151,476,044

G

signal transducer and activator of transcription 3

affects expression

ISO

protopanaxadiol affects the expression of STAT3 protein

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359

G

tumor protein p53

increases expression

ISO

protopanaxadiol results in increased expression of TP53 mRNA; protopanaxadiol results in increased expression of TP53 protein

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

(20S)-ginsenoside Rg3

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily G member 2

multiple interactions
decreases expression

ISO

XMU-MP-1 inhibits the reaction [ginsenoside Rg3 results in decreased expression of ABCG2 mRNA]

NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:89,005,969...89,132,493

G

acid phosphatase 5, tartrate resistant

multiple interactions

EXP

ginsenoside Rg3 inhibits the reaction [Dexamethasone results in increased activity of ACP5 protein]

NCBI chr 8:28,939,984...28,946,639
Ensembl chr 8:28,939,985...28,943,929

G

AKT serine/threonine kinase 1

multiple interactions

ISO

2-(1,3-benzodioxol-5-yl)-N-(5-methyl-4-(1-(2-methylbenzoyl)-2,3-dihydroindol-5-yl)-1,3-thiazol-2-yl)acetamide inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Glucose results in increased phosphorylation of AKT1 protein]]; ginsenoside Rg3 inhibits the reaction [Glucose results in increased phosphorylation of AKT1 protein]
ginsenoside Rg3 inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased phosphorylation of AKT1 protein]

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

androgen receptor

increases degradation
multiple interactions

ISO

ginsenoside Rg3 results in increased degradation of AR protein
ginsenoside Rg3 inhibits the reaction [Testosterone results in increased expression of AR protein]

NCBI chr X:67,135,317...67,304,476
Ensembl chr X:67,135,317...67,304,467

G

amphiregulin

decreases expression

ISO

ginsenoside Rg3 results in decreased expression of AREG mRNA

NCBI chr14:17,256,384...17,265,641
Ensembl chr14:17,256,384...17,265,641

G

activating transcription factor 4

multiple interactions

ISO

ginsenoside Rg3 inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of ATF4 protein]
2-(1,3-benzodioxol-5-yl)-N-(5-methyl-4-(1-(2-methylbenzoyl)-2,3-dihydroindol-5-yl)-1,3-thiazol-2-yl)acetamide inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Glucose results in increased expression of ATF4 protein]]; ginsenoside Rg3 inhibits the reaction [Glucose results in increased expression of ATF4 protein]; ginsenoside Rg3 promotes the reaction [Acetylcysteine inhibits the reaction [Glucose results in increased expression of ATF4 protein]]

NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:113,684,681...113,686,739

G

BCL2 associated X, apoptosis regulator

multiple interactions

ISO

2-(1,3-benzodioxol-5-yl)-N-(5-methyl-4-(1-(2-methylbenzoyl)-2,3-dihydroindol-5-yl)-1,3-thiazol-2-yl)acetamide inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Glucose results in increased expression of BAX protein]]; ginsenoside Rg3 inhibits the reaction [cagA protein, Helicobacter pylori results in decreased expression of BAX protein]; ginsenoside Rg3 inhibits the reaction [Glucose results in increased expression of BAX protein]
ginsenoside Rg3 inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of BAX protein]

PMID:26427350 PMID:39579577

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

multiple interactions

ISO

ginsenoside Rg3 inhibits the reaction [cagA protein, Helicobacter pylori results in increased expression of BCL2 protein]
ginsenoside Rg3 inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of BCL2 protein]

PMID:26427350 PMID:39579577

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

brain-derived neurotrophic factor

multiple interactions

ISO

[Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of BDNF protein]; [staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] inhibits the reaction [[Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of BDNF protein]]

NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657

G

beclin 1

multiple interactions

ISO

ginsenoside Rg3 inhibits the reaction [Cisplatin results in decreased expression of BECN1 protein]
3-methyladenine inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Cisplatin results in decreased expression of BECN1 protein]]; ginsenoside Rg3 inhibits the reaction [Cisplatin results in decreased expression of BECN1 protein]

NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,731,650...86,747,002

G

bone gamma-carboxyglutamate protein

multiple interactions

EXP

ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of BGLAP protein]

NCBI chr 2:176,136,341...176,137,318
Ensembl chr 2:176,136,341...176,137,318

G

baculoviral IAP repeat-containing 5

decreases expression

ISO

ginsenoside Rg3 results in decreased expression of BIRC5 mRNA; ginsenoside Rg3 results in decreased expression of BIRC5 protein

NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,572,080...103,582,155

G

bone morphogenetic protein 2

multiple interactions

EXP

ginsenoside Rg3 inhibits the reaction [Dexamethasone inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of BMP2 protein]]; ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of BMP2 mRNA]; ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of BMP2 protein]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of BMP2 protein]]]

NCBI chr 3:141,264,648...141,275,416
Ensembl chr 3:141,264,646...141,274,760

G

bone morphogenetic protein receptor type 1A

multiple interactions

EXP

ginsenoside Rg3 inhibits the reaction [Dexamethasone inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of BMPR1A protein]]; ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of BMPR1A mRNA]; ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of BMPR1A protein]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of BMPR1A protein]]]

NCBI chr16:9,740,751...9,786,861
Ensembl chr16:9,742,875...9,786,861

G

caspase 1

multiple interactions

ISO

ginsenoside Rg3 inhibits the reaction [Cisplatin results in increased expression of CASP1 protein]

NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:10,746,333...10,882,275

G

caspase 12

multiple interactions

ISO

ginsenoside Rg3 inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased cleavage of CASP12 protein]
2-(1,3-benzodioxol-5-yl)-N-(5-methyl-4-(1-(2-methylbenzoyl)-2,3-dihydroindol-5-yl)-1,3-thiazol-2-yl)acetamide inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Glucose results in increased cleavage of CASP12 protein]]; ginsenoside Rg3 inhibits the reaction [Glucose results in increased cleavage of CASP12 protein]; ginsenoside Rg3 promotes the reaction [Acetylcysteine inhibits the reaction [Glucose results in increased cleavage of CASP12 protein]]

NCBI chr 8:10,927,188...10,954,442
Ensembl chr 8:10,926,994...10,954,442

G

caspase 3

increases cleavage
multiple interactions

ISO

ginsenoside Rg3 results in increased cleavage of CASP3 protein
ginsenoside Rg3 inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased cleavage of CASP3 protein]
2-(1,3-benzodioxol-5-yl)-N-(5-methyl-4-(1-(2-methylbenzoyl)-2,3-dihydroindol-5-yl)-1,3-thiazol-2-yl)acetamide inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Glucose results in increased cleavage of CASP3 protein]]; [ginsenoside Rg3 co-treated with osimertinib] results in increased cleavage of CASP3 protein; ginsenoside Rg3 inhibits the reaction [cagA protein, Helicobacter pylori results in decreased cleavage of CASP3 protein]; ginsenoside Rg3 inhibits the reaction [Glucose results in increased cleavage of CASP3 protein]

PMID:22101440 PMID:26427350 PMID:31916386 PMID:39579577

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 8

multiple interactions

ISO

ginsenoside Rg3 inhibits the reaction [cagA protein, Helicobacter pylori results in decreased cleavage of CASP8 protein]

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699

G

caspase 9

multiple interactions

ISO

2-(1,3-benzodioxol-5-yl)-N-(5-methyl-4-(1-(2-methylbenzoyl)-2,3-dihydroindol-5-yl)-1,3-thiazol-2-yl)acetamide inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Glucose results in increased cleavage of CASP9 protein]]; ginsenoside Rg3 inhibits the reaction [cagA protein, Helicobacter pylori results in decreased cleavage of CASP9 protein]; ginsenoside Rg3 inhibits the reaction [Glucose results in increased cleavage of CASP9 protein]
ginsenoside Rg3 inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased cleavage of CASP9 protein]

PMID:26427350 PMID:39579577

Ensembl chr 5:159,391,188...159,409,648

G

catalase

multiple interactions

EXP
ISO

ginsenoside Rg3 inhibits the reaction [dimethoxon results in decreased activity of CAT protein]
ginsenoside Rg3 inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of CAT protein]
ginsenoside Rg3 inhibits the reaction [Glucose results in decreased expression of CAT protein]

PMID:26240163 PMID:39579577

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

cellular communication network factor 1

decreases expression

ISO

ginsenoside Rg3 results in decreased expression of CCN1 mRNA

NCBI chr 2:237,222,730...237,225,689
Ensembl chr 2:237,222,432...237,225,883

G

cellular communication network factor 2

decreases expression

ISO

ginsenoside Rg3 results in decreased expression of CCN2 mRNA

NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:22,621,501...22,624,976

G

cadherin 1

multiple interactions

ISO

ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]

NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565

G

cytochrome c, somatic

multiple interactions

ISO

ginsenoside Rg3 inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of CYCS protein]
2-(1,3-benzodioxol-5-yl)-N-(5-methyl-4-(1-(2-methylbenzoyl)-2,3-dihydroindol-5-yl)-1,3-thiazol-2-yl)acetamide inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Glucose results in increased expression of CYCS protein]]; ginsenoside Rg3 inhibits the reaction [Glucose results in increased expression of CYCS protein]

NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816

G

DNA-damage inducible transcript 3

multiple interactions

ISO

ginsenoside Rg3 inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of DDIT3 protein]
2-(1,3-benzodioxol-5-yl)-N-(5-methyl-4-(1-(2-methylbenzoyl)-2,3-dihydroindol-5-yl)-1,3-thiazol-2-yl)acetamide inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Glucose results in increased expression of DDIT3 protein]]; [ginsenoside Rg3 co-treated with Acetylcysteine] inhibits the reaction [Glucose results in increased expression of DDIT3 protein]; ginsenoside Rg3 inhibits the reaction [Glucose results in increased expression of DDIT3 protein]

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509

G

dipeptidylpeptidase 4

multiple interactions

ISO

[Xiao-Ke-An results in increased abundance of ginsenoside Rg3] which results in decreased activity of DPP4 protein

NCBI chr 3:67,370,794...67,452,422
Ensembl chr 3:67,370,804...67,452,422

G

epidermal growth factor

multiple interactions

ISO

EGF protein promotes the reaction [ginsenoside Rg3 affects the phosphorylation of EGFR protein]; ginsenoside Rg3 inhibits the reaction [EGF protein promotes the reaction [EGFR protein binds to EGFR protein]]

NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:220,893,660...220,976,297

G

epidermal growth factor receptor

multiple interactions
affects phosphorylation

ISO

EGF protein promotes the reaction [ginsenoside Rg3 affects the phosphorylation of EGFR protein]; ginsenoside Rg3 inhibits the reaction [EGF protein promotes the reaction [EGFR protein binds to EGFR protein]]; ginsenoside Rg3 results in decreased expression of and affects the localization of EGFR protein

NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358

G

eukaryotic translation initiation factor 2 alpha kinase 3

multiple interactions

ISO

ginsenoside Rg3 inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased phosphorylation of EIF2AK3 protein]
2-(1,3-benzodioxol-5-yl)-N-(5-methyl-4-(1-(2-methylbenzoyl)-2,3-dihydroindol-5-yl)-1,3-thiazol-2-yl)acetamide inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Glucose results in increased phosphorylation of EIF2AK3 protein]]; [Acetylcysteine co-treated with ginsenoside Rg3] inhibits the reaction [Glucose results in increased phosphorylation of EIF2AK3 protein]; ginsenoside Rg3 inhibits the reaction [Glucose results in increased phosphorylation of EIF2AK3 protein]

NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:104,363,833...104,425,268

G

epithelial cell adhesion molecule

decreases expression

ISO

ginsenoside Rg3 results in decreased expression of EPCAM mRNA

NCBI chr 6:12,633,715...12,649,678
Ensembl chr 6:12,631,611...12,649,702

G

fucosyltransferase 4

multiple interactions
decreases expression

ISO

ginsenoside Rg3 inhibits the reaction [cagA protein, Helicobacter pylori results in increased expression of FUT4 protein]
ginsenoside Rg3 results in decreased expression of FUT4 protein

NCBI chr 8:19,868,178...19,872,139
Ensembl chr 8:19,868,079...19,872,436

G

heme oxygenase 1

multiple interactions

ISO

ginsenoside Rg3 inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of HMOX1 protein]
2-(1,3-benzodioxol-5-yl)-N-(5-methyl-4-(1-(2-methylbenzoyl)-2,3-dihydroindol-5-yl)-1,3-thiazol-2-yl)acetamide inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Glucose results in decreased expression of HMOX1 protein]]; Acetylcysteine promotes the reaction [ginsenoside Rg3 inhibits the reaction [Glucose results in decreased expression of HMOX1 protein]]; ginsenoside Rg3 inhibits the reaction [Glucose results in decreased expression of HMOX1 protein]

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

heat shock transcription factor 1

multiple interactions
decreases expression

ISO

ginsenoside Rg3 inhibits the reaction [cagA protein, Helicobacter pylori results in increased expression of HSF1 protein]
ginsenoside Rg3 results in decreased expression of HSF1 protein

NCBI chr 7:110,076,710...110,103,665
Ensembl chr 7:110,076,710...110,103,665

G

heat shock protein family A (Hsp70) member 5

multiple interactions

ISO

ginsenoside Rg3 inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of HSPA5 protein]
2-(1,3-benzodioxol-5-yl)-N-(5-methyl-4-(1-(2-methylbenzoyl)-2,3-dihydroindol-5-yl)-1,3-thiazol-2-yl)acetamide inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Glucose results in increased expression of HSPA5 protein]]; [Acetylcysteine co-treated with ginsenoside Rg3] inhibits the reaction [Glucose results in increased expression of HSPA5 protein]; ginsenoside Rg3 inhibits the reaction [Glucose results in increased expression of HSPA5 protein]

NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790

G

interleukin 1 beta

increases expression
multiple interactions

EXP
ISO

ginsenoside Rg3 results in increased expression of IL1B protein
ginsenoside Rg3 inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; ginsenoside Rg3 inhibits the reaction [Cisplatin results in increased expression of IL1B protein]

PMID:14534150 PMID:33050067 PMID:34423507

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 6

multiple interactions

ISO

ginsenoside Rg3 inhibits the reaction [Galactose results in increased secretion of IL6 protein]

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

insulin 1

multiple interactions

ISO

ginsenoside Rg3 inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of INS1 protein]

NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682

G

KIT proto-oncogene receptor tyrosine kinase

decreases expression

ISO

ginsenoside Rg3 results in decreased expression of KIT mRNA

NCBI chr14:32,901,615...32,978,895
Ensembl chr14:32,903,033...32,978,812

G

KLF transcription factor 4

decreases expression

ISO

ginsenoside Rg3 results in decreased expression of KLF4 mRNA

NCBI chr 5:75,074,107...75,079,182
Ensembl chr 5:75,074,236...75,078,592

G

kallikrein 1-related peptidase C10

multiple interactions

ISO

ginsenoside Rg3 inhibits the reaction [Testosterone results in increased expression of KLK3 mRNA]; ginsenoside Rg3 inhibits the reaction [Testosterone results in increased expression of KLK3 protein]

NCBI chr 1:103,539,527...103,543,586
Ensembl chr 1:103,539,527...103,543,586

G

large tumor suppressor kinase 1

increases expression

ISO

ginsenoside Rg3 results in increased expression of LATS1 mRNA

NCBI chr 1:3,980,801...4,014,029
Ensembl chr 1:3,980,544...4,014,029

G

large tumor suppressor kinase 2

increases expression

ISO

ginsenoside Rg3 results in increased expression of LATS2 mRNA

NCBI chr15:35,940,632...35,992,225
Ensembl chr15:35,940,632...35,980,842

G

microtubule-associated protein 2

increases expression

ISO

ginsenoside Rg3 results in increased expression of MAP2 mRNA

NCBI chr 9:75,173,038...75,431,606
Ensembl chr 9:75,288,262...75,428,459

G

marker of proliferation Ki-67

multiple interactions

ISO

[ginsenoside Rg3 co-treated with osimertinib] results in decreased expression of MKI67 protein

NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:199,926,150...199,952,593

G

matrix metallopeptidase 2

multiple interactions

ISO

ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased expression of and results in increased activity of MMP2 protein]; ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased expression of MMP2 mRNA]

NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856

G

myeloperoxidase

multiple interactions

EXP

ginsenoside Rg3 inhibits the reaction [dimethoxon results in increased activity of MPO protein]

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056

G

MYC proto-oncogene, bHLH transcription factor

decreases expression

ISO

ginsenoside Rg3 results in decreased expression of MYC mRNA

NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028

G

Nanog homeobox

decreases expression

ISO

ginsenoside Rg3 results in decreased expression of NANOG mRNA

NCBI chr 4:157,615,687...157,623,061
Ensembl chr 4:157,615,687...157,623,061

G

NFE2 like bZIP transcription factor 2

multiple interactions

ISO

ginsenoside Rg3 inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of and affects the localization of NFE2L2 protein]

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

nuclear factor kappa B subunit 1

multiple interactions
increases activity

EXP

[ginsenoside Rg3 results in increased phosphorylation of and results in increased degradation of NFKBIA protein] which results in increased activity of NFKB1 protein
ginsenoside Rg3 results in increased activity of NFKB1 protein

NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088

G

NFKB inhibitor alpha

multiple interactions

EXP

[ginsenoside Rg3 results in increased phosphorylation of and results in increased degradation of NFKBIA protein] which results in increased activity of NFKB1 protein; [ginsenoside Rg3 results in increased phosphorylation of and results in increased degradation of NFKBIA protein] which results in increased activity of RELA protein

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072

G

NLR family, pyrin domain containing 3

multiple interactions

ISO

ginsenoside Rg3 inhibits the reaction [Cisplatin results in increased expression of NLRP3 protein]
3-methyladenine inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Cisplatin results in increased expression of NLRP3 protein]]; ginsenoside Rg3 inhibits the reaction [Cisplatin results in increased expression of NLRP3 protein]

NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,828,014...44,853,394

G

noggin

multiple interactions

EXP

NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of BMP2 protein]]]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of BMPR1A protein]]]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of RUNX2 protein]]]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of TNFRSF11B mRNA]]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of TNFRSF11B protein]]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone results in increased expression of TNFSF11 mRNA]]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone results in increased expression of TNFSF11 protein]]

NCBI chr10:74,625,874...74,627,501
Ensembl chr10:74,625,875...74,628,103

G

nitric oxide synthase 2

multiple interactions
increases expression

EXP

Staurosporine inhibits the reaction [ginsenoside Rg3 results in increased expression of NOS2 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [ginsenoside Rg3 results in increased expression of NOS2 protein]
ginsenoside Rg3 results in increased expression of NOS2 mRNA

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

neurotrophic receptor tyrosine kinase 2

multiple interactions

ISO

[staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] inhibits the reaction [[Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of BDNF protein]]; [staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] inhibits the reaction [[Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] results in decreased susceptibility to Chlorodiphenyl (54% Chlorine)]; [staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] results in decreased susceptibility to [Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3]
[Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of NTRK2 protein modified form]; [staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] inhibits the reaction [[Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] results in decreased susceptibility to Chlorodiphenyl (54% Chlorine)]; [staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] results in decreased susceptibility to [Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3]

NCBI chr17:5,560,558...5,875,899
Ensembl chr17:5,564,570...5,874,628

G

occludin

multiple interactions

ISO

2-(1,3-benzodioxol-5-yl)-N-(5-methyl-4-(1-(2-methylbenzoyl)-2,3-dihydroindol-5-yl)-1,3-thiazol-2-yl)acetamide inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Glucose results in decreased expression of OCLN protein]]; [ginsenoside Rg3 co-treated with Acetylcysteine] inhibits the reaction [Glucose results in decreased expression of OCLN protein]; ginsenoside Rg3 inhibits the reaction [Glucose results in decreased expression of OCLN protein]
ginsenoside Rg3 inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of OCLN protein]

NCBI chr 2:33,391,303...33,442,207
Ensembl chr 2:33,391,303...33,430,411

G

poly (ADP-ribose) polymerase 1

increases cleavage
multiple interactions

ISO

ginsenoside Rg3 results in increased cleavage of PARP1 protein
[ginsenoside Rg3 co-treated with osimertinib] results in increased cleavage of PARP1 protein; ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased cleavage of PARP1 protein]; ginsenoside Rg3 inhibits the reaction [cagA protein, Helicobacter pylori results in decreased cleavage of PARP1 protein]

PMID:22101440 PMID:24793912 PMID:26427350 PMID:31916386

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

phosphoenolpyruvate carboxykinase 1

increases expression

EXP

ginsenoside Rg3 results in increased expression of PCK1 mRNA

NCBI chr 3:182,348,572...182,354,521
Ensembl chr 3:182,348,572...182,354,561

G

POU class 5 homeobox 1

decreases expression

ISO

ginsenoside Rg3 results in decreased expression of POU5F1 mRNA

NCBI chr20:3,227,836...3,232,598
Ensembl chr20:3,227,837...3,232,598

G

PPARG coactivator 1 alpha

increases expression

EXP

ginsenoside Rg3 results in increased expression of PPARGC1A mRNA

NCBI chr14:63,073,505...63,729,215
Ensembl chr14:63,273,189...63,729,213

G

prominin 1

decreases expression
multiple interactions

ISO

ginsenoside Rg3 results in decreased expression of PROM1 mRNA
XMU-MP-1 inhibits the reaction [ginsenoside Rg3 results in decreased expression of PROM1 mRNA]

NCBI chr14:71,202,303...71,307,008
Ensembl chr14:71,202,336...71,307,002

G

PYD and CARD domain containing

multiple interactions

ISO

ginsenoside Rg3 inhibits the reaction [Cisplatin results in increased expression of PYCARD protein]
3-methyladenine inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Cisplatin results in increased expression of PYCARD protein]]; ginsenoside Rg3 inhibits the reaction [Cisplatin results in increased expression of PYCARD protein]

NCBI chr 1:192,032,124...192,033,419
Ensembl chr 1:192,032,124...192,033,419

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

EXP
ISO

[ginsenoside Rg3 results in increased phosphorylation of and results in increased degradation of NFKBIA protein] which results in increased activity of RELA protein; ginsenoside Rg3 affects the localization of and results in increased activity of RELA protein
ginsenoside Rg3 results in decreased expression of and results in decreased phosphorylation of RELA protein

PMID:14534150 PMID:33050067

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

RUNX family transcription factor 2

multiple interactions

EXP

ginsenoside Rg3 inhibits the reaction [Dexamethasone inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of RUNX2 protein]]; ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of RUNX2 mRNA]; ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of RUNX2 protein]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of RUNX2 protein]]]

NCBI chr 9:23,661,278...23,990,248
Ensembl chr 9:23,664,952...23,990,027

G

spalt-like transcription factor 4

decreases expression

ISO

ginsenoside Rg3 results in decreased expression of SALL4 mRNA

NCBI chr 3:177,891,705...177,909,743
Ensembl chr 3:177,891,705...177,909,743

G

sirtuin 1

increases activity

EXP

ginsenoside Rg3 results in increased activity of SIRT1 protein

NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000

G

solute carrier family 6 member 2

multiple interactions

ISO

[Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of SLC6A2 protein]

NCBI chr19:30,183,289...30,228,292
Ensembl chr19:30,183,383...30,223,348

G

solute carrier family 6 member 3

multiple interactions

ISO

[Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of SLC6A3 protein]

NCBI chr 1:31,537,990...31,578,962
Ensembl chr 1:31,537,990...31,578,962

G

SMAD family member 2

multiple interactions

ISO

ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]

NCBI chr18:72,124,792...72,193,345
Ensembl chr18:72,124,863...72,187,388

G

snail family transcriptional repressor 1

multiple interactions

ISO

ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 mRNA]; ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 protein]

NCBI chr 3:176,667,476...176,671,965

G

SRY-box transcription factor 2

decreases expression

ISO

ginsenoside Rg3 results in decreased expression of SOX2 mRNA

NCBI chr 2:119,465,131...119,467,542
Ensembl chr 2:119,454,541...119,496,350

G

Sp1 transcription factor

multiple interactions

ISO

ginsenoside Rg3 inhibits the reaction [cagA protein, Helicobacter pylori results in decreased expression of SP1 protein]

NCBI chr 7:135,419,864...135,450,513
Ensembl chr 7:135,420,050...135,450,513

G

sequestosome 1

multiple interactions

ISO

ginsenoside Rg3 inhibits the reaction [Cisplatin results in increased expression of SQSTM1 protein]
3-methyladenine affects the reaction [ginsenoside Rg3 affects the reaction [Cisplatin affects the expression of SQSTM1 protein]]; ginsenoside Rg3 affects the reaction [Cisplatin affects the expression of SQSTM1 protein]

NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750

G

serine/threonine kinase 3

increases expression

ISO

ginsenoside Rg3 results in increased expression of STK3 mRNA

NCBI chr 7:67,938,341...68,208,472
Ensembl chr 7:67,938,378...68,208,508

G

serine/threonine kinase 4

increases expression

ISO

ginsenoside Rg3 results in increased expression of STK4 mRNA

NCBI chr 3:173,165,238...173,247,135
Ensembl chr 3:173,165,083...173,247,134

G

transforming growth factor, beta 1

multiple interactions

ISO

ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]; ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased cleavage of PARP1 protein]; ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased expression of and results in increased activity of MMP2 protein]; ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased expression of MMP2 mRNA]; ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 mRNA]; ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 protein]; ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]; ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899

G

Thy-1 cell surface antigen

decreases expression

ISO

ginsenoside Rg3 results in decreased expression of THY1 mRNA

NCBI chr 8:53,286,396...53,291,541
Ensembl chr 8:53,286,148...53,291,540

G

tight junction protein 1

multiple interactions

ISO

ginsenoside Rg3 inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of TJP1 protein]
2-(1,3-benzodioxol-5-yl)-N-(5-methyl-4-(1-(2-methylbenzoyl)-2,3-dihydroindol-5-yl)-1,3-thiazol-2-yl)acetamide inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Glucose results in decreased expression of TJP1 protein]]; [Acetylcysteine co-treated with ginsenoside Rg3] inhibits the reaction [Glucose results in decreased expression of TJP1 protein]; ginsenoside Rg3 inhibits the reaction [Glucose results in decreased expression of TJP1 protein]

NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:128,260,330...128,505,158

G

tumor necrosis factor

increases expression
multiple interactions

EXP
ISO

ginsenoside Rg3 results in increased expression of TNF protein
ginsenoside Rg3 inhibits the reaction [dimethoxon results in increased expression of TNF protein]
ginsenoside Rg3 inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of TNF protein]; ginsenoside Rg3 inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]

PMID:14534150 PMID:26240163 PMID:33050067

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

TNF receptor superfamily member 11B

multiple interactions

EXP

ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of TNFRSF11B mRNA]; ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of TNFRSF11B protein]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of TNFRSF11B mRNA]]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of TNFRSF11B protein]]

NCBI chr 7:87,456,318...87,484,324
Ensembl chr 7:87,456,319...87,485,075

G

TNF superfamily member 11

multiple interactions

EXP

ginsenoside Rg3 inhibits the reaction [Dexamethasone results in increased expression of TNFSF11 mRNA]; ginsenoside Rg3 inhibits the reaction [Dexamethasone results in increased expression of TNFSF11 protein]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone results in increased expression of TNFSF11 mRNA]]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone results in increased expression of TNFSF11 protein]]

NCBI chr15:60,083,008...60,114,479
Ensembl chr15:60,083,008...60,114,479

G

vascular endothelial growth factor A

multiple interactions

ISO

2-(1,3-benzodioxol-5-yl)-N-(5-methyl-4-(1-(2-methylbenzoyl)-2,3-dihydroindol-5-yl)-1,3-thiazol-2-yl)acetamide inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Glucose results in increased expression of VEGFA protein]]; Acetylcysteine promotes the reaction [ginsenoside Rg3 inhibits the reaction [Glucose results in increased expression of VEGFA protein]]; ginsenoside Rg3 inhibits the reaction [Glucose results in increased expression of VEGFA protein]
ginsenoside Rg3 inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of VEGFA protein]

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194

G

vimentin

multiple interactions

ISO

ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]

NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746

G

WW domain containing transcription regulator 1

decreases expression

ISO

ginsenoside Rg3 results in decreased expression of WWTR1 mRNA

NCBI chr 2:143,801,181...143,916,941
Ensembl chr 2:143,801,181...143,991,950

G

Yes1 associated transcriptional regulator

decreases expression

ISO

ginsenoside Rg3 results in decreased expression of YAP1 mRNA

NCBI chr 8:13,380,551...13,451,640
Ensembl chr 8:13,380,551...13,451,437

(20S)-ginsenoside Rh1

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression

ISO

ginsenoside Rh1 results in increased expression of FOS mRNA

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598

G

intercellular adhesion molecule 1

multiple interactions

ISO

ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]

NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617

G

interleukin 1 beta

multiple interactions

ISO

ginsenoside Rh1 inhibits the reaction [Oxazolone results in increased expression of IL1B mRNA]; ginsenoside Rh1 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL1B mRNA]

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 4

decreases expression

ISO

ginsenoside Rh1 results in decreased expression of IL4

NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549

G

interleukin 6

multiple interactions

ISO

ginsenoside Rh1 inhibits the reaction [Galactose results in increased secretion of IL6 protein]

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

integrin subunit alpha 4

multiple interactions

ISO

ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of [ITGA4 protein binds to ITGB1 protein]]

NCBI chr 3:84,569,487...84,646,276
Ensembl chr 3:84,560,369...84,641,039

G

integrin subunit alpha L

multiple interactions

ISO

ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of [ITGAL protein binds to ITGB2 protein]]

NCBI chr 1:191,348,424...191,386,228
Ensembl chr 1:191,348,542...191,386,225

G

integrin subunit beta 1

multiple interactions

ISO

ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of [ITGA4 protein binds to ITGB1 protein]]

NCBI chr19:73,602,277...73,650,271
Ensembl chr19:73,602,126...73,650,269

G

integrin subunit beta 2

multiple interactions

ISO

ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of [ITGAL protein binds to ITGB2 protein]]

NCBI chr20:11,061,009...11,097,242
Ensembl chr20:11,058,492...11,097,182

G

Jun proto-oncogene, AP-1 transcription factor subunit

decreases activity

ISO

ginsenoside Rh1 results in decreased activity of JUN protein

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285

G

lipoprotein lipase

increases secretion

ISO

ginsenoside Rh1 results in increased secretion of LPL protein

NCBI chr16:25,596,205...25,621,928
Ensembl chr16:25,596,211...25,622,107

G

progesterone receptor

increases expression

ISO

ginsenoside Rh1 results in increased expression of PGR protein

NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:14,354,398...14,413,271

G

peroxisome proliferator-activated receptor gamma

multiple interactions

ISO

ginsenoside Rh1 inhibits the reaction [bisphenol A results in increased expression of PPARG mRNA]; ginsenoside Rh1 inhibits the reaction [bisphenol A results in increased expression of PPARG protein]

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104

G

prostaglandin-endoperoxide synthase 2

multiple interactions

ISO

ginsenoside Rh1 inhibits the reaction [Oxazolone results in increased expression of PTGS2 mRNA]; ginsenoside Rh1 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 mRNA]

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

selectin E

multiple interactions

ISO

ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of SELE protein]

NCBI chr13:78,935,997...78,945,905
Ensembl chr13:78,936,036...78,945,903

G

trefoil factor 1

increases expression

ISO

ginsenoside Rh1 results in increased expression of TFF1 mRNA

NCBI chr20:9,237,095...9,240,956
Ensembl chr20:9,237,095...9,240,956

G

tumor necrosis factor

multiple interactions
decreases expression
decreases response to substance

ISO

ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of [ITGA4 protein binds to ITGB1 protein]]; ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of [ITGAL protein binds to ITGB2 protein]]; ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of SELE protein]; ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
ginsenoside Rh1 inhibits the reaction [Oxazolone results in increased expression of TNF mRNA]; ginsenoside Rh1 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNF mRNA]
ginsenoside Rh1 results in decreased expression of TNF
ginsenoside Rh1 results in decreased susceptibility to TNF protein

PMID:16557482 PMID:21875580 PMID:22855946

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

vascular cell adhesion molecule 1

multiple interactions

ISO

ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]

NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801

(20S)-ginsenoside Rh2

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

decreases phosphorylation

ISO

ginsenoside Rh2 results in decreased phosphorylation of AKT1 protein

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

BCL2 associated X, apoptosis regulator

increases expression

ISO

ginsenoside Rh2 results in increased expression of BAX protein

PMID:26482938 PMID:32762018

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

decreases expression

ISO

ginsenoside Rh2 results in decreased expression of BCL2 protein

PMID:26482938 PMID:32762018

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

caspase 3

increases cleavage
decreases expression

ISO

ginsenoside Rh2 results in increased cleavage of CASP3 protein
ginsenoside Rh2 results in decreased expression of CASP3 protein

PMID:26482938 PMID:32762018

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 9

decreases expression

ISO

ginsenoside Rh2 results in decreased expression of CASP9 protein

Ensembl chr 5:159,391,188...159,409,648

G

cyclin D1

decreases expression

ISO

ginsenoside Rh2 results in decreased expression of CCND1 protein

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810

G

histone deacetylase 1

decreases expression

ISO

ginsenoside Rh2 results in decreased expression of HDAC1 protein

NCBI chr 5:147,138,328...147,165,387
Ensembl chr 5:147,138,156...147,165,387

G

histone deacetylase 2

decreases expression

ISO

ginsenoside Rh2 results in decreased expression of HDAC2 protein

NCBI chr20:42,101,815...42,126,486
Ensembl chr20:42,102,861...42,126,311

G

histone deacetylase 6

decreases expression

ISO

ginsenoside Rh2 results in decreased expression of HDAC6 protein

NCBI chr X:17,222,538...17,244,373
Ensembl chr X:17,222,856...17,244,370

G

interleukin 6

multiple interactions

ISO

ginsenoside Rh2 inhibits the reaction [Galactose results in increased secretion of IL6 protein]

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

mitogen activated protein kinase 1

decreases phosphorylation
increases phosphorylation

ISO

ginsenoside Rh2 results in decreased phosphorylation of MAPK1 protein
ginsenoside Rh2 results in increased phosphorylation of MAPK1 protein

PMID:26482938 PMID:32762018

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

decreases phosphorylation
increases phosphorylation

ISO

ginsenoside Rh2 results in decreased phosphorylation of MAPK3 protein
ginsenoside Rh2 results in increased phosphorylation of MAPK3 protein

PMID:26482938 PMID:32762018

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

mechanistic target of rapamycin kinase

decreases phosphorylation

ISO

ginsenoside Rh2 results in decreased phosphorylation of MTOR protein

NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435

G

NFKB inhibitor alpha

increases expression

ISO

ginsenoside Rh2 results in increased expression of NFKBIA protein

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

ISO

ginsenoside Rh2 results in increased expression of and results in decreased phosphorylation of RELA protein

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

24,25-dihydrolanosterol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 51

decreases abundance

ISO

CYP51A1 mRNA results in decreased abundance of lanostenol

NCBI chr 4:30,991,693...31,010,147
Ensembl chr 4:30,991,613...31,010,450

G

3-hydroxy-3-methylglutaryl-CoA reductase

decreases activity

ISO

lanostenol results in decreased activity of HMGCR protein

NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533

3beta-hydroxylanost-8-en-32-al

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

3-hydroxy-3-methylglutaryl-CoA reductase

decreases activity

ISO

lanosten-3-ol-32-al results in decreased activity of HMGCR protein

NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

caspase 3

increases activity

ISO

azadiradione results in increased activity of CASP3 protein

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 8

increases activity

ISO

azadiradione results in increased activity of CASP8 protein

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699

G

caspase 9

increases activity

ISO

azadiradione results in increased activity of CASP9 protein

Ensembl chr 5:159,391,188...159,409,648

G

heat shock protein family A (Hsp70) member 1A

increases expression

ISO

azadiradione results in increased expression of HSPA1A mRNA

NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,855,780...3,877,979

Benzo[a]fluorene

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aryl hydrocarbon receptor

affects binding

EXP

benzo(a)fluorene binds to AHR protein

NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901

G

aldo-keto reductase family 1, member C1

increases expression

ISO

benzo(a)fluorene results in increased expression of AKR1C1 mRNA

NCBI chr17:70,720,397...70,747,285
Ensembl chr17:70,720,398...70,747,247

G

aldehyde dehydrogenase 3 family, member A1

multiple interactions

ISO

[retene co-treated with benzo(a)fluorene co-treated with benzo(b)fluorene co-treated with benzo(c)fluorene co-treated with triphenylene co-treated with benzo(e)pyrene co-treated with 1,12-benzoperylene] results in increased expression of ALDH3A1 mRNA

NCBI chr10:46,392,464...46,402,151
Ensembl chr10:46,392,411...46,402,151

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression
multiple interactions

ISO

benzo(a)fluorene results in increased expression of CYP1A1 mRNA
[retene co-treated with benzo(a)fluorene co-treated with benzo(b)fluorene co-treated with benzo(c)fluorene co-treated with triphenylene co-treated with benzo(e)pyrene co-treated with 1,12-benzoperylene] results in increased expression of CYP1A1 mRNA

PMID:17253728 PMID:38673911

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 1, subfamily b, polypeptide 1

increases expression
multiple interactions

ISO

benzo(a)fluorene results in increased expression of CYP1B1 mRNA
[retene co-treated with benzo(a)fluorene co-treated with benzo(b)fluorene co-treated with benzo(c)fluorene co-treated with triphenylene co-treated with benzo(e)pyrene co-treated with 1,12-benzoperylene] results in increased expression of CYP1B1 mRNA

NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142

G

glutathione S-transferase alpha 1

increases expression

ISO

benzo(a)fluorene results in increased expression of GSTA1 mRNA

NCBI chr 9:31,199,887...31,216,606
Ensembl chr 9:31,199,888...31,211,528

G

heme oxygenase 1

multiple interactions
increases expression

ISO

[retene co-treated with benzo(a)fluorene co-treated with benzo(b)fluorene co-treated with benzo(c)fluorene co-treated with triphenylene co-treated with benzo(e)pyrene co-treated with 1,12-benzoperylene] results in increased expression of HMOX1 mRNA
benzo(a)fluorene results in increased expression of HMOX1 mRNA

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

NAD(P)H quinone dehydrogenase 1

increases expression

ISO

benzo(a)fluorene results in increased expression of NQO1 mRNA

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260

G

tight junction protein 2

multiple interactions
increases expression

ISO

[retene co-treated with benzo(a)fluorene co-treated with benzo(b)fluorene co-treated with benzo(c)fluorene co-treated with triphenylene co-treated with benzo(e)pyrene co-treated with 1,12-benzoperylene] results in increased expression of TJP2 mRNA
benzo(a)fluorene results in increased expression of TJP2 mRNA

NCBI chr 1:231,136,218...231,264,750
Ensembl chr 1:231,136,243...231,264,750

Benzo[b]fluorene

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 3

increases expression

EXP

benzo(b)fluorene results in increased expression of ABCC3 mRNA

NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,793,583...79,839,494

G

ATP binding cassette subfamily G member 5

decreases expression

EXP

benzo(b)fluorene results in decreased expression of ABCG5 mRNA

NCBI chr 6:15,717,936...15,743,376
Ensembl chr 6:15,717,936...15,743,376

G

acetyl-CoA acetyltransferase 1

increases expression

EXP

benzo(b)fluorene results in increased expression of ACAT1 mRNA

NCBI chr 8:62,876,003...62,905,080
Ensembl chr 8:62,876,003...62,905,042

G

acyl-CoA synthetase long-chain family member 1

decreases expression

EXP

benzo(b)fluorene results in decreased expression of ACSL1 mRNA

NCBI chr16:52,487,870...52,554,110
Ensembl chr16:52,487,870...52,554,023

G

aryl hydrocarbon receptor

affects binding

EXP

benzo(b)fluorene binds to AHR protein

NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901

G

aldo-keto reductase family 1, member C1

increases expression

ISO

benzo(b)fluorene results in increased expression of AKR1C1 mRNA

NCBI chr17:70,720,397...70,747,285
Ensembl chr17:70,720,398...70,747,247

G

aldehyde dehydrogenase 3 family, member A1

increases expression
multiple interactions

ISO

benzo(b)fluorene results in increased expression of ALDH3A1 mRNA
[retene co-treated with benzo(a)fluorene co-treated with benzo(b)fluorene co-treated with benzo(c)fluorene co-treated with triphenylene co-treated with benzo(e)pyrene co-treated with 1,12-benzoperylene] results in increased expression of ALDH3A1 mRNA

NCBI chr10:46,392,464...46,402,151
Ensembl chr10:46,392,411...46,402,151

G

angiopoietin-like 4

decreases expression

EXP

benzo(b)fluorene results in decreased expression of ANGPTL4 mRNA

NCBI chr 7:15,252,450...15,259,971
Ensembl chr 7:15,252,473...15,258,681

G

cyclin-dependent kinase inhibitor 1A

decreases expression

EXP

benzo(b)fluorene results in decreased expression of CDKN1A mRNA

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression
multiple interactions

ISO

benzo(b)fluorene results in increased expression of CYP1A1 mRNA
[retene co-treated with benzo(a)fluorene co-treated with benzo(b)fluorene co-treated with benzo(c)fluorene co-treated with triphenylene co-treated with benzo(e)pyrene co-treated with 1,12-benzoperylene] results in increased expression of CYP1A1 mRNA

PMID:17253728 PMID:38673911

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 1, subfamily a, polypeptide 2

increases expression

ISO
EXP

benzo(b)fluorene results in increased expression of CYP1A2 mRNA

PMID:17253728 PMID:38903859

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149

G

cytochrome P450, family 1, subfamily b, polypeptide 1

multiple interactions
increases expression

ISO

[retene co-treated with benzo(a)fluorene co-treated with benzo(b)fluorene co-treated with benzo(c)fluorene co-treated with triphenylene co-treated with benzo(e)pyrene co-treated with 1,12-benzoperylene] results in increased expression of CYP1B1 mRNA
benzo(b)fluorene results in increased expression of CYP1B1 mRNA

NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142

G

cytochrome P450 family 7 subfamily A member 1

affects expression

EXP

benzo(b)fluorene affects the expression of CYP7A1 mRNA

NCBI chr 5:24,174,505...24,184,202
Ensembl chr 5:24,174,505...24,184,202

G

G0/G1switch 2

affects expression

EXP

benzo(b)fluorene affects the expression of G0S2 mRNA

NCBI chr13:107,335,036...107,335,948
Ensembl chr13:107,335,036...107,336,293

G

glutathione S-transferase alpha 1

increases expression

ISO

benzo(b)fluorene results in increased expression of GSTA1 mRNA

NCBI chr 9:31,199,887...31,216,606
Ensembl chr 9:31,199,888...31,211,528

G

heme oxygenase 1

multiple interactions
increases expression

ISO

[retene co-treated with benzo(a)fluorene co-treated with benzo(b)fluorene co-treated with benzo(c)fluorene co-treated with triphenylene co-treated with benzo(e)pyrene co-treated with 1,12-benzoperylene] results in increased expression of HMOX1 mRNA
benzo(b)fluorene results in increased expression of HMOX1 mRNA

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

insulin-like growth factor binding protein 1

affects expression

EXP

benzo(b)fluorene affects the expression of IGFBP1 mRNA

NCBI chr14:86,261,277...86,266,344
Ensembl chr14:86,261,277...86,266,344

G

insulin-like growth factor binding protein 3

decreases expression

EXP

benzo(b)fluorene results in decreased expression of IGFBP3 mRNA

NCBI chr14:86,270,208...86,277,944
Ensembl chr14:86,270,208...86,277,944

G

MFSD2 lysolipid transporter A, lysophospholipid

decreases expression

EXP

benzo(b)fluorene results in decreased expression of MFSD2A mRNA

NCBI chr 5:140,510,933...140,525,828
Ensembl chr 5:140,510,953...140,525,916

G

MYC proto-oncogene, bHLH transcription factor

decreases expression

EXP

benzo(b)fluorene results in decreased expression of MYC mRNA

NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028

G

NAD(P)H quinone dehydrogenase 1

increases expression

ISO
EXP

benzo(b)fluorene results in increased expression of NQO1 mRNA

PMID:17253728 PMID:38673911 PMID:38903859

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260

G

phosphoenolpyruvate carboxykinase 1

affects expression

EXP

benzo(b)fluorene affects the expression of PCK1 mRNA

NCBI chr 3:182,348,572...182,354,521
Ensembl chr 3:182,348,572...182,354,561

G

stearoyl-CoA desaturase

decreases expression

EXP

benzo(b)fluorene results in decreased expression of SCD mRNA

NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:253,218,970...253,231,785

G

tyrosine aminotransferase

affects expression

EXP

benzo(b)fluorene affects the expression of TAT mRNA

NCBI chr19:54,856,604...54,867,168
Ensembl chr19:54,856,563...54,867,482

G

tight junction protein 2

multiple interactions

ISO

[retene co-treated with benzo(a)fluorene co-treated with benzo(b)fluorene co-treated with benzo(c)fluorene co-treated with triphenylene co-treated with benzo(e)pyrene co-treated with 1,12-benzoperylene] results in increased expression of TJP2 mRNA

NCBI chr 1:231,136,218...231,264,750
Ensembl chr 1:231,136,243...231,264,750

Benzo[c]fluorene

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aldehyde dehydrogenase 3 family, member A1

multiple interactions

ISO

[retene co-treated with benzo(a)fluorene co-treated with benzo(b)fluorene co-treated with benzo(c)fluorene co-treated with triphenylene co-treated with benzo(e)pyrene co-treated with 1,12-benzoperylene] results in increased expression of ALDH3A1 mRNA

NCBI chr10:46,392,464...46,402,151
Ensembl chr10:46,392,411...46,402,151

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression
multiple interactions

ISO

benzo(c)fluorene results in increased expression of CYP1A1 mRNA
[retene co-treated with benzo(a)fluorene co-treated with benzo(b)fluorene co-treated with benzo(c)fluorene co-treated with triphenylene co-treated with benzo(e)pyrene co-treated with 1,12-benzoperylene] results in increased expression of CYP1A1 mRNA

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 1, subfamily b, polypeptide 1

increases expression
multiple interactions

ISO

benzo(c)fluorene results in increased expression of CYP1B1 mRNA
[retene co-treated with benzo(a)fluorene co-treated with benzo(b)fluorene co-treated with benzo(c)fluorene co-treated with triphenylene co-treated with benzo(e)pyrene co-treated with 1,12-benzoperylene] results in increased expression of CYP1B1 mRNA

NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142

G

glutathione S-transferase alpha 1

increases expression

ISO

benzo(c)fluorene results in increased expression of GSTA1 mRNA

NCBI chr 9:31,199,887...31,216,606
Ensembl chr 9:31,199,888...31,211,528

G

heme oxygenase 1

multiple interactions

ISO

[retene co-treated with benzo(a)fluorene co-treated with benzo(b)fluorene co-treated with benzo(c)fluorene co-treated with triphenylene co-treated with benzo(e)pyrene co-treated with 1,12-benzoperylene] results in increased expression of HMOX1 mRNA

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

NAD(P)H quinone dehydrogenase 1

increases expression

ISO

benzo(c)fluorene results in increased expression of NQO1 mRNA

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260

G

tight junction protein 2

multiple interactions

ISO

[retene co-treated with benzo(a)fluorene co-treated with benzo(b)fluorene co-treated with benzo(c)fluorene co-treated with triphenylene co-treated with benzo(e)pyrene co-treated with 1,12-benzoperylene] results in increased expression of TJP2 mRNA

NCBI chr 1:231,136,218...231,264,750
Ensembl chr 1:231,136,243...231,264,750

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

actin alpha 2, smooth muscle

multiple interactions

ISO

cucurbitacin B inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA]

NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503

G

adiponectin, C1Q and collagen domain containing

decreases expression

ISO

cucurbitacin B results in decreased expression of ADIPOQ mRNA

NCBI chr11:91,226,524...91,240,244
Ensembl chr11:91,226,180...91,240,169

G

BCL2-associated agonist of cell death

increases expression
multiple interactions

ISO

cucurbitacin B results in increased expression of BAD mRNA
[cucurbitacin B co-treated with Gefitinib] results in increased expression of BAD mRNA

NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:213,562,187...213,572,034

G

BCL2-antagonist/killer 1

multiple interactions
increases expression

ISO

[cucurbitacin B co-treated with Gefitinib] results in increased expression of BAK1 mRNA; [cucurbitacin B co-treated with Gefitinib] results in increased expression of BAK1 protein
cucurbitacin B results in increased expression of BAK1 mRNA; cucurbitacin B results in increased expression of BAK1 protein

NCBI chr20:5,102,334...5,111,615
Ensembl chr20:5,102,335...5,110,974

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression

ISO

cucurbitacin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of BAX mRNA]
cucurbitacin B results in increased expression of BAX mRNA; cucurbitacin B results in increased expression of BAX protein
[cucurbitacin B co-treated with Gefitinib] results in increased expression of BAX mRNA; [cucurbitacin B co-treated with Gefitinib] results in increased expression of BAX protein

PMID:26183715 PMID:29250925

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

multiple interactions
decreases expression

ISO

cucurbitacin B inhibits the reaction [Carbon Tetrachloride results in increased expression of BCL2 mRNA]
[cucurbitacin B co-treated with Gefitinib] results in decreased expression of BCL2 mRNA; [cucurbitacin B co-treated with Gefitinib] results in decreased expression of BCL2 protein
cucurbitacin B results in decreased expression of BCL2 mRNA; cucurbitacin B results in decreased expression of BCL2 protein

PMID:26183715 PMID:29250925

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

Bcl2-like 1

multiple interactions
decreases expression

ISO

[cucurbitacin B co-treated with Gefitinib] results in decreased expression of BCL2L1 mRNA
cucurbitacin B results in decreased expression of BCL2L1 mRNA

NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907

G

Bcl2-like 11

increases expression
multiple interactions

ISO

cucurbitacin B results in increased expression of BCL2L11 mRNA
[cucurbitacin B co-treated with Gefitinib] results in increased expression of BCL2L11 mRNA

NCBI chr 3:135,820,042...135,857,330
Ensembl chr 3:135,817,562...135,960,695

G

caspase 3

increases cleavage
multiple interactions

ISO

cucurbitacin B results in increased cleavage of CASP3 protein
[cucurbitacin B co-treated with Gefitinib] results in increased cleavage of CASP3 protein

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

catalase

multiple interactions

ISO

cucurbitacin B inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein]

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

C-C motif chemokine ligand 2

multiple interactions

ISO

cucurbitacin B inhibits the reaction [Gefitinib results in increased expression of CCL2 mRNA]

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

cyclin D1

decreases expression
multiple interactions

ISO

cucurbitacin B results in decreased expression of CCND1
[cucurbitacin B co-treated with Gefitinib] results in decreased expression of CCND1 mRNA; [cucurbitacin B co-treated with Gefitinib] results in decreased expression of CCND1 protein
cucurbitacin B results in decreased expression of CCND1 mRNA; cucurbitacin B results in decreased expression of CCND1 protein

PMID:24316209 PMID:26183715

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810

G

CD36 molecule

decreases expression

ISO

cucurbitacin B results in decreased expression of CD36 mRNA

NCBI chr 4:18,209,088...18,302,142

G

cyclin-dependent kinase inhibitor 1B

multiple interactions
increases expression

ISO

[cucurbitacin B co-treated with Gefitinib] results in increased expression of CDKN1B protein
cucurbitacin B results in increased expression of CDKN1B protein

NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498

G

CCAAT/enhancer binding protein alpha

decreases expression
multiple interactions

ISO

cucurbitacin B results in decreased expression of CEBPA mRNA
STAT3 protein affects the reaction [cucurbitacin B results in decreased expression of CEBPA mRNA]

NCBI chr 1:96,896,584...96,899,256
Ensembl chr 1:96,896,171...96,899,309

G

CCAAT/enhancer binding protein delta

decreases expression

ISO

cucurbitacin B results in decreased expression of CEBPD

NCBI chr11:98,268,856...98,269,994
Ensembl chr11:98,265,651...98,280,824

G

collagen type I alpha 1 chain

multiple interactions

ISO

cucurbitacin B inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]

NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460

G

epidermal growth factor receptor

multiple interactions

ISO

[cucurbitacin B co-treated with Gefitinib] results in decreased phosphorylation of EGFR protein

NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358

G

fatty acid binding protein 4

decreases expression

ISO

cucurbitacin B results in decreased expression of FABP4 mRNA

NCBI chr 2:93,488,251...93,492,961
Ensembl chr 2:93,488,271...93,492,972

G

glutamic-oxaloacetic transaminase 1

multiple interactions

ISO

cucurbitacin B inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of GOT1 protein]
cucurbitacin B inhibits the reaction [Lithocholic Acid results in increased expression of GOT1 protein]

NCBI chr 1:252,306,541...252,337,622
Ensembl chr 1:252,284,434...252,329,871

G

glutamic--pyruvic transaminase

multiple interactions

ISO

cucurbitacin B inhibits the reaction [Lithocholic Acid results in increased expression of GPT protein]
cucurbitacin B inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of GPT protein]

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

hypoxia inducible factor 1 subunit alpha

multiple interactions

ISO

cucurbitacin B inhibits the reaction [Lithocholic Acid results in increased expression of HIF1A mRNA]; cucurbitacin B inhibits the reaction [Lithocholic Acid results in increased expression of HIF1A protein]
cucurbitacin B inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of HIF1A mRNA]; cucurbitacin B inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of HIF1A protein]

NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323

G

interleukin 1 beta

multiple interactions

ISO

cucurbitacin B inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased secretion of IL1B protein]; cucurbitacin B inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B protein]
cucurbitacin B inhibits the reaction [Lithocholic Acid results in increased expression of IL1B mRNA]

PMID:29250925 PMID:38104874

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 6

multiple interactions

ISO

cucurbitacin B inhibits the reaction [Lithocholic Acid results in increased expression of IL6 mRNA]; cucurbitacin B inhibits the reaction [Lithocholic Acid results in increased expression of IL6 protein]
cucurbitacin B inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL6 mRNA]; cucurbitacin B inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL6 protein]; cucurbitacin B inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased secretion of IL6 protein]

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

KLF transcription factor 5

increases expression

ISO

cucurbitacin B results in increased expression of KLF5

NCBI chr15:82,472,081...82,487,267
Ensembl chr15:82,472,065...82,487,262

G

matrix metallopeptidase 2

multiple interactions

ISO

cucurbitacin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of MMP2 mRNA]

NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856

G

peroxisome proliferator-activated receptor gamma

multiple interactions
decreases expression

ISO

STAT3 protein affects the reaction [cucurbitacin B results in decreased expression of PPARG mRNA]

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104

G

signal transducer and activator of transcription 3

multiple interactions
decreases phosphorylation
affects response to substance

ISO

[WP1066 results in decreased activity of STAT3 protein] which results in decreased susceptibility to cucurbitacin B; cucurbitacin B inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of STAT3 mRNA]; cucurbitacin B inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of STAT3 protein]; cucurbitacin B inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of STAT3 protein]; cucurbitacin B results in decreased phosphorylation of and results in decreased activity of STAT3 protein; STAT3 protein affects the reaction [cucurbitacin B results in decreased expression of CEBPA mRNA]; STAT3 protein affects the reaction [cucurbitacin B results in decreased expression of PPARG mRNA]
cucurbitacin B results in decreased phosphorylation of STAT3 protein
[cucurbitacin B co-treated with Gefitinib] results in decreased phosphorylation of STAT3 protein; cucurbitacin B inhibits the reaction [Lithocholic Acid results in increased expression of and results in increased phosphorylation of STAT3 mRNA]
STAT3 protein affects the susceptibility to cucurbitacin B

PMID:24316209 PMID:26183715 PMID:29250925 PMID:38104874

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359

G

transforming growth factor, beta 1

multiple interactions

ISO

cucurbitacin B inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899

G

tumor necrosis factor

multiple interactions

ISO

cucurbitacin B inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of TNF mRNA]; cucurbitacin B inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of TNF protein]; cucurbitacin B inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased secretion of TNF protein]; cucurbitacin B inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]
cucurbitacin B inhibits the reaction [Lithocholic Acid results in increased expression of TNF mRNA]; cucurbitacin B inhibits the reaction [Lithocholic Acid results in increased expression of TNF protein]

PMID:29250925 PMID:38104874

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

actin alpha 2, smooth muscle

decreases expression
multiple interactions

EXP
ISO

cucurbitacin E results in decreased expression of ACTA2 mRNA; cucurbitacin E results in decreased expression of ACTA2 protein
cucurbitacin E inhibits the reaction [Thioacetamide results in increased expression of ACTA2 protein]

NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503

G

AKT serine/threonine kinase 1

multiple interactions
affects phosphorylation

ISO

Acetylcysteine inhibits the reaction [cucurbitacin E affects the phosphorylation of AKT1 protein]

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

BCL2 associated X, apoptosis regulator

increases expression

ISO
EXP

cucurbitacin E results in increased expression of BAX protein

PMID:27106530 PMID:27363783

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

decreases expression

ISO
EXP

cucurbitacin E results in decreased expression of BCL2 protein

PMID:27106530 PMID:27363783

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

Bcl2-like 1

decreases expression

ISO

cucurbitacin E results in decreased expression of BCL2L1 protein

NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907

G

beclin 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [cucurbitacin E results in increased expression of and results in increased phosphorylation of BECN1 protein]; cucurbitacin E results in increased expression of and results in increased phosphorylation of BECN1 protein

NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,731,650...86,747,002

G

caspase 3

multiple interactions
increases cleavage

ISO
EXP

acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [cucurbitacin E results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [cucurbitacin E results in increased cleavage of CASP3 protein]

PMID:27106530 PMID:27363783

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 7

multiple interactions
increases cleavage

ISO

acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [cucurbitacin E results in increased cleavage of CASP7 protein]; Acetylcysteine inhibits the reaction [cucurbitacin E results in increased cleavage of CASP7 protein]

NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512

G

caspase 9

increases cleavage

ISO

cucurbitacin E results in increased cleavage of CASP9 protein

Ensembl chr 5:159,391,188...159,409,648

G

collagen type I alpha 1 chain

decreases expression

EXP

cucurbitacin E results in decreased expression of COL1A1 mRNA

NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460

G

mitogen activated protein kinase 1

decreases phosphorylation

EXP

cucurbitacin E results in decreased phosphorylation of MAPK1 protein

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

decreases phosphorylation

EXP

cucurbitacin E results in decreased phosphorylation of MAPK3 protein

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

mechanistic target of rapamycin kinase

multiple interactions
decreases phosphorylation

ISO
EXP

Acetylcysteine inhibits the reaction [cucurbitacin E results in decreased phosphorylation of MTOR protein]
cucurbitacin E inhibits the reaction [Thioacetamide results in increased phosphorylation of MTOR protein]

PMID:27106530 PMID:27363783

NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435

G

poly (ADP-ribose) polymerase 1

multiple interactions
increases cleavage

ISO
EXP

acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [cucurbitacin E results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [cucurbitacin E results in increased cleavage of PARP1 protein]

PMID:27106530 PMID:27363783

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

phosphatase and tensin homolog

multiple interactions

ISO

cucurbitacin E results in increased expression of and results in increased phosphorylation of PTEN protein

NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:240,043,707...240,110,330

G

ribosomal protein S6 kinase B1

multiple interactions
decreases phosphorylation

ISO
EXP

cucurbitacin E inhibits the reaction [Thioacetamide results in increased phosphorylation of RPS6KB1 protein]
cucurbitacin E results in decreased phosphorylation of RPS6KB1 protein

NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,815,614...71,865,238

G

sequestosome 1

multiple interactions
increases expression

ISO

Acetylcysteine inhibits the reaction [cucurbitacin E results in increased expression of SQSTM1 protein]

NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750

G

TIMP metallopeptidase inhibitor 1

multiple interactions
decreases expression

ISO
EXP

cucurbitacin E inhibits the reaction [Thioacetamide results in increased expression of TIMP1 protein]
cucurbitacin E results in decreased expression of TIMP1 mRNA; cucurbitacin E results in decreased expression of TIMP1 protein

NCBI chr X:3,766,509...3,772,578
Ensembl chr X:3,766,510...3,771,135

G

unc-51 like autophagy activating kinase 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [cucurbitacin E results in decreased expression of and results in decreased phosphorylation of ULK1 protein]; cucurbitacin E results in decreased expression of and results in decreased phosphorylation of ULK1 protein

NCBI chr12:51,511,492...51,537,746
Ensembl chr12:51,511,492...51,537,746

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

multiple interactions

ISO

cucurbitacin I inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

G

adiponectin, C1Q and collagen domain containing

multiple interactions

EXP

cucurbitacin I inhibits the reaction [ADIPOQ protein results in increased expression of HMOX1 mRNA]

NCBI chr11:91,226,524...91,240,244
Ensembl chr11:91,226,180...91,240,169

G

caspase 3

increases cleavage

ISO

cucurbitacin I results in increased cleavage of CASP3 protein

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 7

increases cleavage

ISO

cucurbitacin I results in increased cleavage of CASP7 protein

NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512

G

caspase 8

increases cleavage

ISO

cucurbitacin I results in increased cleavage of CASP8 protein

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699

G

caspase 9

increases cleavage

ISO

cucurbitacin I results in increased cleavage of CASP9 protein

Ensembl chr 5:159,391,188...159,409,648

G

cyclin A2

decreases expression

ISO

cucurbitacin I results in decreased expression of CCNA2 protein

NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:121,355,363...121,361,701

G

cyclin B1

decreases expression

ISO

cucurbitacin I results in decreased expression of CCNB1 protein

NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225

G

cyclin D1

decreases expression

ISO

cucurbitacin I results in decreased expression of CCND1

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810

G

CD36 molecule

decreases expression

ISO

cucurbitacin I results in decreased expression of CD36 mRNA

NCBI chr 4:18,209,088...18,302,142

G

cell division cycle 25C

decreases expression

ISO

cucurbitacin I results in decreased expression of CDC25C protein

NCBI chr18:26,608,483...26,630,292
Ensembl chr18:26,609,959...26,630,292

G

cyclin-dependent kinase 1

decreases expression

ISO

cucurbitacin I results in decreased expression of CDK1 protein

NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,265,289...19,280,455

G

CCAAT/enhancer binding protein alpha

decreases expression

ISO

cucurbitacin I results in decreased expression of CEBPA mRNA

NCBI chr 1:96,896,584...96,899,256
Ensembl chr 1:96,896,171...96,899,309

G

fatty acid binding protein 4

decreases expression

ISO

cucurbitacin I results in decreased expression of FABP4 mRNA

NCBI chr 2:93,488,251...93,492,961
Ensembl chr 2:93,488,271...93,492,972

G

heme oxygenase 1

multiple interactions

EXP

cucurbitacin I inhibits the reaction [ADIPOQ protein results in increased expression of HMOX1 mRNA]

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

interleukin 21

multiple interactions

ISO

cucurbitacin I inhibits the reaction [IL21 protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of IL22 mRNA]]

NCBI chr 2:122,045,240...122,055,142
Ensembl chr 2:122,045,240...122,055,142

G

Janus kinase 2

multiple interactions

ISO

cucurbitacin I inhibits the reaction [glycine-extended gastrin 17 results in increased phosphorylation of and results in increased activity of JAK2 protein]

NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:236,408,662...236,468,762

G

KLF transcription factor 5

increases expression

ISO

cucurbitacin I results in increased expression of KLF5

NCBI chr15:82,472,081...82,487,267
Ensembl chr15:82,472,065...82,487,262

G

natriuretic peptide A

increases expression

EXP

cucurbitacin I results in increased expression of NPPA mRNA

NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:163,712,184...163,713,493

G

natriuretic peptide B

increases expression

EXP

cucurbitacin I results in increased expression of NPPB mRNA

NCBI chr 5:163,699,955...163,701,314
Ensembl chr 5:163,699,839...163,701,310

G

poly (ADP-ribose) polymerase 1

increases cleavage

ISO

cucurbitacin I results in increased cleavage of PARP1 protein

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

peroxisome proliferator-activated receptor gamma

decreases expression

ISO

cucurbitacin I results in decreased expression of PPARG mRNA

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104

G

signal transducer and activator of transcription 3

multiple interactions
affects response to substance
decreases activity

ISO

cucurbitacin I inhibits the reaction [glycine-extended gastrin 17 results in increased phosphorylation of and results in increased activity of STAT3 protein]
[WP1066 results in decreased activity of STAT3 protein] which results in decreased susceptibility to cucurbitacin I
STAT3 protein affects the susceptibility to cucurbitacin I
cucurbitacin I results in decreased activity of STAT3 protein

PMID:19153190 PMID:24316209

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359

G

vascular endothelial growth factor A

multiple interactions

ISO

cucurbitacin I inhibits the reaction [Arsenic results in increased expression of VEGFA protein]

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

androgen receptor

multiple interactions

ISO

ganoderol B binds to and results in decreased activity of AR protein; ganoderol B inhibits the reaction [Dihydrotestosterone binds to AR protein]

NCBI chr X:67,135,317...67,304,476
Ensembl chr X:67,135,317...67,304,467

G

kallikrein 1-related peptidase C10

decreases expression

ISO

ganoderol B results in decreased expression of KLK3 mRNA

NCBI chr 1:103,539,527...103,543,586
Ensembl chr 1:103,539,527...103,543,586

G

steroid 5 alpha-reductase 1

decreases activity

EXP

ganoderol B results in decreased activity of SRD5A1 protein

NCBI chr 1:35,514,914...35,548,898
Ensembl chr 1:35,514,846...35,548,903

ginsenoside C-K

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

C-X-C motif chemokine receptor 1

multiple interactions

ISO

ginsenoside compound K inhibits the reaction [TNF protein results in increased expression of CXCR1 protein]

NCBI chr 9:83,216,040...83,220,225
Ensembl chr 9:83,215,292...83,226,872

G

intercellular adhesion molecule 1

multiple interactions

ISO

ginsenoside compound K inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]

NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617

G

interferon gamma

decreases expression

ISO

ginsenoside compound K results in decreased expression of IFNG mRNA

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

interleukin 1 beta

decreases expression

ISO

ginsenoside compound K results in decreased expression of IL1B mRNA

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 4

decreases expression

ISO

ginsenoside compound K results in decreased expression of IL4 mRNA

NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549

G

interleukin 6

multiple interactions

ISO

ginsenoside compound K inhibits the reaction [Galactose results in increased secretion of IL6 protein]

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

integrin subunit alpha 4

multiple interactions

ISO

ginsenoside compound K inhibits the reaction [TNF protein results in increased expression of [ITGA4 protein binds to ITGB1 protein]]

NCBI chr 3:84,569,487...84,646,276
Ensembl chr 3:84,560,369...84,641,039

G

integrin subunit alpha L

multiple interactions

ISO

ginsenoside compound K inhibits the reaction [TNF protein results in increased expression of [ITGAL protein binds to ITGB2 protein]]

NCBI chr 1:191,348,424...191,386,228
Ensembl chr 1:191,348,542...191,386,225

G

integrin subunit beta 1

multiple interactions

ISO

ginsenoside compound K inhibits the reaction [TNF protein results in increased expression of [ITGA4 protein binds to ITGB1 protein]]

NCBI chr19:73,602,277...73,650,271
Ensembl chr19:73,602,126...73,650,269

G

integrin subunit beta 2

multiple interactions

ISO

ginsenoside compound K inhibits the reaction [TNF protein results in increased expression of [ITGAL protein binds to ITGB2 protein]]

NCBI chr20:11,061,009...11,097,242
Ensembl chr20:11,058,492...11,097,182

G

matrix metallopeptidase 9

decreases secretion

ISO

ginsenoside compound K results in decreased secretion of MMP9 protein

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442

G

nuclear factor kappa B subunit 1

multiple interactions

EXP

ginsenoside compound K results in decreased activity of [NFKB1 protein binds to RELA protein]

NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088

G

nitric oxide synthase 2

multiple interactions

EXP

ginsenoside compound K results in decreased expression of and results in decreased activity of NOS2 protein

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

purinergic receptor P2X 4

multiple interactions

ISO

[ginsenoside compound K co-treated with Adenosine Triphosphate] results in increased activity of P2RX4 protein; ginsenoside compound K promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]

NCBI chr12:39,505,438...39,523,349
Ensembl chr12:39,505,438...39,523,094

G

purinergic receptor P2X 7

decreases response to substance

ISO

P2RX7 gene mutant form results in decreased susceptibility to ginsenoside compound K

NCBI chr12:39,550,531...39,594,984
Ensembl chr12:39,540,567...39,595,193

G

prostaglandin-endoperoxide synthase 2

decreases expression

ISO
EXP

ginsenoside compound K results in decreased expression of PTGS2 mRNA
ginsenoside compound K results in decreased expression of PTGS2 protein

PMID:15802804 PMID:15914323

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

EXP

ginsenoside compound K results in decreased activity of [NFKB1 protein binds to RELA protein]

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

selectin E

multiple interactions

ISO

ginsenoside compound K inhibits the reaction [TNF protein results in increased expression of SELE protein]

NCBI chr13:78,935,997...78,945,905
Ensembl chr13:78,936,036...78,945,903

G

tumor necrosis factor

multiple interactions
decreases expression
decreases response to substance

ISO

ginsenoside compound K inhibits the reaction [TNF protein results in increased expression of [ITGA4 protein binds to ITGB1 protein]]; ginsenoside compound K inhibits the reaction [TNF protein results in increased expression of [ITGAL protein binds to ITGB2 protein]]; ginsenoside compound K inhibits the reaction [TNF protein results in increased expression of CXCR1 protein]; ginsenoside compound K inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; ginsenoside compound K inhibits the reaction [TNF protein results in increased expression of SELE protein]; ginsenoside compound K inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; ginsenoside compound K inhibits the reaction [TNF protein results in increased secretion of CXCL8 protein]
ginsenoside compound K results in decreased expression of TNF mRNA
ginsenoside compound K results in decreased susceptibility to TNF protein

PMID:15914323 PMID:21875580

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

vascular cell adhesion molecule 1

multiple interactions

ISO

ginsenoside compound K inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]

NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

interleukin 6

multiple interactions

ISO

ginsenoside F1 inhibits the reaction [Galactose results in increased secretion of IL6 protein]

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

ISO

ginsenoside F1 inhibits the reaction [Galactose affects the localization of RELA protein]

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

multiple interactions

ISO

ginsenoside F2 analog inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

ginsenoside Rb1

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

multiple interactions
increases phosphorylation

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rb1 results in increased phosphorylation of AKT1 protein]; Fulvestrant inhibits the reaction [ginsenoside Rb1 results in increased phosphorylation of AKT1 protein]; Pertussis Toxin inhibits the reaction [ginsenoside Rb1 results in increased phosphorylation of AKT1 protein]

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

ATPase H+ transporting V1 subunit A

multiple interactions

ISO

ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of ATP6V1A mRNA]

NCBI chr11:70,066,800...70,120,603
Ensembl chr11:70,035,134...70,120,603

G

ATPase H+ transporting V1 subunit B2

multiple interactions

ISO

ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of ATP6V1B2 mRNA]

NCBI chr16:25,384,254...25,408,388
Ensembl chr16:25,384,257...25,408,839

G

bone morphogenetic protein 2

multiple interactions
increases expression

EXP

ginsenoside Rb1 inhibits the reaction [aluminum chloride results in decreased expression of BMP2 mRNA]
ginsenoside Rb1 results in increased expression of BMP2 mRNA

NCBI chr 3:141,264,648...141,275,416
Ensembl chr 3:141,264,646...141,274,760

G

caspase 1

multiple interactions

EXP
ISO

Cyclosporine inhibits the reaction [ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased cleavage of CASP1 protein]]; ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased cleavage of CASP1 protein]

NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:10,746,333...10,882,275

G

caspase 3

multiple interactions

ISO

ginsenoside Rb1 inhibits the reaction [Oxidopamine results in increased activity of CASP3 protein]

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

chloride voltage-gated channel 7

multiple interactions

ISO

ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of CLCN7 mRNA]

NCBI chr10:14,656,261...14,681,632
Ensembl chr10:14,656,245...14,681,631

G

cathepsin B

multiple interactions

ISO

ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of CTSB mRNA]

NCBI chr15:41,565,607...41,586,479
Ensembl chr15:41,565,611...41,586,478

G

cathepsin D

multiple interactions

ISO

ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of CTSD mRNA]

NCBI chr 1:206,956,945...206,968,821
Ensembl chr 1:206,956,944...206,968,821

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

ISO

ginsenoside Rb1 inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA]

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598

G

gasdermin D

multiple interactions

EXP
ISO

Cyclosporine inhibits the reaction [ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased cleavage of GSDMD protein]]; ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased cleavage of GSDMD protein]

NCBI chr 7:109,423,209...109,427,771
Ensembl chr 7:109,422,910...109,430,722

G

heme oxygenase 1

multiple interactions
increases expression

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 protein]; Cycloheximide inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 mRNA]; Cycloheximide inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 protein]; Dactinomycin inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 protein]; fulvestrant inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 mRNA]; fulvestrant inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 protein]; ginsenoside Rb1 results in increased expression of and results in increased activity of HMOX1 protein; Pertussis Toxin inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 mRNA]; Pertussis Toxin inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 protein]
[astragaloside A co-treated with ginsenoside Rg1 co-treated with ginsenoside Rb1 co-treated with notoginsenoside R1] results in increased expression of HMOX1 mRNA; [astragaloside A co-treated with ginsenoside Rg1 co-treated with ginsenoside Rb1 co-treated with notoginsenoside R1] results in increased expression of HMOX1 protein

PMID:19781563 PMID:25422538

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

insulin-like growth factor 1

multiple interactions
increases expression

EXP

ginsenoside Rb1 inhibits the reaction [aluminum chloride results in decreased expression of IGF1 mRNA]
ginsenoside Rb1 results in increased expression of IGF1 mRNA

NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:24,130,137...24,246,764

G

interleukin 18

multiple interactions

EXP
ISO

ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased secretion of IL18 protein]
ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased expression of and results in increased secretion of IL18 protein]

NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:59,809,592...59,831,286

G

interleukin 1 beta

multiple interactions

ISO
EXP

ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased expression of and results in increased secretion of IL1B protein]
ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased secretion of IL1B protein]

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 6

multiple interactions

EXP

ginsenoside Rb1 inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

integrin subunit alpha M

multiple interactions

EXP

ginsenoside Rb1 inhibits the reaction [Lipopolysaccharides results in increased expression of ITGAM protein]

NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:192,089,542...192,139,943

G

integrin subunit beta 2

multiple interactions

EXP

ginsenoside Rb1 inhibits the reaction [Lipopolysaccharides results in increased expression of ITGB2 protein]

NCBI chr20:11,061,009...11,097,242
Ensembl chr20:11,058,492...11,097,182

G

potassium voltage-gated channel subfamily E regulatory subunit 1

increases expression

ISO

ginsenoside Rb1 results in increased expression of KCNE1

NCBI chr11:45,066,875...45,080,024
Ensembl chr11:45,064,162...45,081,247

G

potassium voltage-gated channel subfamily H member 2

affects activity

ISO

ginsenoside Rb1 affects the activity of KCNH2 protein

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421

G

lysosomal-associated membrane protein 1

multiple interactions

ISO

ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of LAMP1 mRNA]

NCBI chr16:83,058,131...83,082,843
Ensembl chr16:83,058,385...83,075,159

G

lactate dehydrogenase A

multiple interactions

ISO

Chloroquine inhibits the reaction [ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased secretion of LDHA protein]]; ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased secretion of LDHA protein]

NCBI chr 1:106,508,092...106,517,512
Ensembl chr 1:106,502,182...106,517,521

G

microtubule-associated protein 1 light chain 3 beta

multiple interactions

EXP
ISO

Cyclosporine inhibits the reaction [ginsenoside Rb1 promotes the reaction [alpha-Chlorohydrin results in increased lipidation of and results in increased localization of MAP1LC3B protein]]; ginsenoside Rb1 promotes the reaction [alpha-Chlorohydrin results in increased lipidation of and results in increased localization of MAP1LC3B protein]

NCBI chr19:66,571,631...66,582,270
Ensembl chr19:66,574,407...66,584,358
Ensembl chr16:66,574,407...66,584,358

G

microtubule-associated protein 2

increases expression

ISO

ginsenoside Rb1 results in increased expression of MAP2 mRNA

NCBI chr 9:75,173,038...75,431,606
Ensembl chr 9:75,288,262...75,428,459

G

nuclear factor of activated T-cells 1

multiple interactions

ISO

ginsenoside Rb1 inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]

NCBI chr18:76,321,386...76,430,997
Ensembl chr18:76,321,386...76,430,990

G

NFE2 like bZIP transcription factor 2

multiple interactions
affects localization
increases expression

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rb1 results in increased localization of NFE2L2 protein]; [ginsenoside Rb1 co-treated with ginsenoside 20S-protopanaxatriol] results in increased expression of NFE2L2 protein; fulvestrant inhibits the reaction [ginsenoside Rb1 results in increased localization of NFE2L2 protein]; ginsenoside Rb1 results in increased activity of and results in increased localization of NFE2L2 protein; Pertussis Toxin inhibits the reaction [ginsenoside Rb1 results in increased localization of NFE2L2 protein]
ginsenoside Rb1 affects the localization of NFE2L2 protein
[astragaloside A co-treated with ginsenoside Rg1 co-treated with ginsenoside Rb1 co-treated with notoginsenoside R1] affects the localization of NFE2L2 protein
ginsenoside Rb1 results in increased expression of NFE2L2 mRNA

PMID:19781563 PMID:22780686 PMID:25422538

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

NLR family, pyrin domain containing 3

multiple interactions

EXP
ISO

Cyclosporine inhibits the reaction [ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased expression of NLRP3 protein]]; ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased expression of NLRP3 protein]

NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,828,014...44,853,394

G

purinergic receptor P2X 4

multiple interactions

ISO

ginsenoside Rb1 promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]

NCBI chr12:39,505,438...39,523,349
Ensembl chr12:39,505,438...39,523,094

G

progesterone receptor

increases expression

ISO

ginsenoside Rb1 results in increased expression of PGR protein

NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:14,354,398...14,413,271

G

PTEN induced kinase 1

multiple interactions

EXP
ISO

Cyclosporine inhibits the reaction [ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of PINK1 protein]]; ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of PINK1 protein]; TFEB protein promotes the reaction [ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of PINK1 protein]]

NCBI chr 5:155,813,838...155,825,950
Ensembl chr 5:155,813,838...155,825,950

G

parkin RBR E3 ubiquitin protein ligase

multiple interactions

EXP

Cyclosporine inhibits the reaction [ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of PARK protein]]; ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of PARK protein]; TFEB protein promotes the reaction [ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of PARK protein]]

NCBI chr 1:51,236,410...52,430,242
Ensembl chr 1:51,210,330...52,430,304

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

ISO

ginsenoside Rb1 inhibits the reaction [TNFSF11 protein affects the localization of RELA protein]

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

RUNX family transcription factor 2

increases expression
multiple interactions

EXP

ginsenoside Rb1 results in increased expression of RUNX2 mRNA
ginsenoside Rb1 inhibits the reaction [aluminum chloride results in decreased expression of RUNX2 mRNA]

NCBI chr 9:23,661,278...23,990,248
Ensembl chr 9:23,664,952...23,990,027

G

solute carrier organic anion transporter family member 1B2

multiple interactions

ISO

ginsenoside Rb1 binds to and results in decreased activity of SLCO1B3 protein

NCBI chr 4:176,282,577...176,355,557
Ensembl chr 4:176,282,584...176,351,083

G

sequestosome 1

multiple interactions
decreases expression

ISO
EXP

ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased expression of SQSTM1 protein]
Cyclosporine inhibits the reaction [ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased expression of SQSTM1 protein]]; ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased expression of SQSTM1 protein]; TFEB protein promotes the reaction [ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased expression of SQSTM1 protein]]
ginsenoside Rb1 results in decreased expression of SQSTM1 protein

PMID:34812491 PMID:38373586

NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750

G

transcription factor EB

multiple interactions

ISO
EXP

[ginsenoside Rb1 co-treated with alpha-Chlorohydrin] affects the localization of TFEB protein; ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of TFEB mRNA]
ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of and affects the localization of TFEB protein]
ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of and affects the localization of TFEB protein]; TFEB protein promotes the reaction [ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of PARK protein]]; TFEB protein promotes the reaction [ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of PINK1 protein]]; TFEB protein promotes the reaction [ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased expression of SQSTM1 protein]]

PMID:34812491 PMID:38373586

NCBI chr 9:20,696,440...20,752,265
Ensembl chr 9:20,696,441...20,727,863

G

transforming growth factor, beta 1

multiple interactions
increases expression

EXP

ginsenoside Rb1 inhibits the reaction [aluminum chloride results in decreased expression of TGFB1 mRNA]
ginsenoside Rb1 results in increased expression of TGFB1 mRNA

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899

G

tumor necrosis factor

multiple interactions

ISO

ginsenoside Rb1 inhibits the reaction [TNFSF11 protein results in increased expression of TNF mRNA]

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

TNF superfamily member 11

multiple interactions
decreases response to substance

ISO

ginsenoside Rb1 inhibits the reaction [TNFSF11 protein affects the localization of RELA protein]; ginsenoside Rb1 inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA]; ginsenoside Rb1 inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]; ginsenoside Rb1 inhibits the reaction [TNFSF11 protein results in increased expression of TNF mRNA]
ginsenoside Rb1 results in decreased susceptibility to TNFSF11 protein

NCBI chr15:60,083,008...60,114,479
Ensembl chr15:60,083,008...60,114,479

ginsenoside Rb2

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 2

increases expression

EXP

ginsenoside Rb2 results in increased expression of ABCC2 mRNA

NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471

G

lipoprotein lipase

increases secretion
decreases secretion

ISO

ginsenoside Rb2 results in increased secretion of LPL protein
ginsenoside Rb2 results in decreased secretion of LPL protein

NCBI chr16:25,596,205...25,621,928
Ensembl chr16:25,596,211...25,622,107

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

solute carrier organic anion transporter family member 1B2

multiple interactions

ISO

ginsenoside Rc binds to and results in decreased activity of SLCO1B3 protein

NCBI chr 4:176,282,577...176,355,557
Ensembl chr 4:176,282,584...176,351,083

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

multiple interactions

ISO

ginsenoside Rd results in increased phosphorylation of and results in increased activity of AKT1 protein

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

amyloid beta precursor protein

multiple interactions

EXP

ginsenoside Rd inhibits the reaction [APP protein modified form results in decreased expression of BCL2 mRNA]; ginsenoside Rd inhibits the reaction [APP protein modified form results in increased expression of BAX mRNA]; ginsenoside Rd inhibits the reaction [APP protein modified form results in increased expression of CASP3 protein modified form]; ginsenoside Rd inhibits the reaction [APP protein modified form results in increased expression of CYCS mRNA]

NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971

G

BCL2 associated X, apoptosis regulator

multiple interactions

EXP

ginsenoside Rd inhibits the reaction [APP protein modified form results in increased expression of BAX mRNA]

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

multiple interactions

EXP

ginsenoside Rd inhibits the reaction [APP protein modified form results in decreased expression of BCL2 mRNA]

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

caspase 3

multiple interactions

EXP

ginsenoside Rd inhibits the reaction [APP protein modified form results in increased expression of CASP3 protein modified form]

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

catalase

increases expression

EXP

ginsenoside Rd results in increased expression of CAT protein

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

cyclin-dependent kinase inhibitor 1A

increases expression
multiple interactions

ISO

ginsenoside Rd results in increased expression of CDKN1A mRNA
staurosporine aglycone inhibits the reaction [ginsenoside Rd results in increased expression of CDKN1A mRNA]

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

choline O-acetyltransferase

increases expression
multiple interactions

ISO

ginsenoside Rd results in increased expression of CHAT mRNA; ginsenoside Rd results in increased expression of CHAT protein
staurosporine aglycone inhibits the reaction [ginsenoside Rd results in increased expression of CHAT mRNA]; staurosporine aglycone inhibits the reaction [ginsenoside Rd results in increased expression of CHAT protein]

NCBI chr16:7,663,665...7,723,416
Ensembl chr16:7,663,665...7,723,416

G

cytochrome c, somatic

multiple interactions

EXP

ginsenoside Rd inhibits the reaction [APP protein modified form results in increased expression of CYCS mRNA]

NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816

G

lipoprotein lipase

decreases secretion

ISO

ginsenoside Rd results in decreased secretion of LPL protein

NCBI chr16:25,596,205...25,621,928
Ensembl chr16:25,596,211...25,622,107

G

microtubule-associated protein 2

increases expression

ISO

ginsenoside Rd results in increased expression of MAP2 mRNA; ginsenoside Rd results in increased expression of MAP2 protein

NCBI chr 9:75,173,038...75,431,606
Ensembl chr 9:75,288,262...75,428,459

G

mitogen activated protein kinase 1

multiple interactions

ISO

ginsenoside Rd results in increased phosphorylation of and results in increased activity of MAPK1 protein

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

multiple interactions

ISO

ginsenoside Rd results in increased phosphorylation of and results in increased activity of MAPK3 protein

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

nerve growth factor

increases expression

ISO

ginsenoside Rd results in increased expression of NGF mRNA

NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:192,589,582...192,643,834

G

nerve growth factor receptor

increases expression

ISO

ginsenoside Rd results in increased expression of NGFR mRNA; ginsenoside Rd results in increased expression of NGFR protein

NCBI chr10:81,012,077...81,030,305
Ensembl chr10:81,012,089...81,030,305

G

purinergic receptor P2X 4

multiple interactions

ISO

ginsenoside Rd promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]

NCBI chr12:39,505,438...39,523,349
Ensembl chr12:39,505,438...39,523,094

G

purinergic receptor P2X 7

decreases response to substance

ISO

P2RX7 gene mutant form results in decreased susceptibility to ginsenoside Rd

NCBI chr12:39,550,531...39,594,984
Ensembl chr12:39,540,567...39,595,193

G

solute carrier family 18 member A3

increases expression

ISO

ginsenoside Rd results in increased expression of SLC18A3 mRNA

NCBI chr16:7,719,953...7,722,814

G

solute carrier family 5 member 7

increases expression

ISO

ginsenoside Rd results in increased expression of SLC5A7 mRNA

NCBI chr 9:7,922,693...7,953,509
Ensembl chr 9:7,922,697...7,953,509

G

solute carrier organic anion transporter family member 1B2

multiple interactions

ISO

ginsenoside Rd binds to and results in decreased activity of SLCO1B3 protein

NCBI chr 4:176,282,577...176,355,557
Ensembl chr 4:176,282,584...176,351,083

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

increases transport

EXP
ISO

ABCB11 protein results in increased transport of ginsenoside Re

NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581

G

ATP binding cassette subfamily C member 1

increases transport

ISO

ABCC1 protein results in increased transport of ginsenoside Re

NCBI chr10:1,022,041...1,162,431
Ensembl chr10:1,038,947...1,162,404

G

ATP binding cassette subfamily C member 2

increases transport

EXP
ISO

ABCC2 protein results in increased transport of ginsenoside Re

NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471

G

ATP binding cassette subfamily G member 2

increases transport

EXP
ISO

ABCG2 protein results in increased transport of ginsenoside Re

NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:89,005,969...89,132,493

G

adiponectin, C1Q and collagen domain containing

increases expression
multiple interactions

ISO

ginsenoside Re results in increased expression of ADIPOQ mRNA
ginsenoside Re results in increased expression of and results in increased secretion of ADIPOQ protein

NCBI chr11:91,226,524...91,240,244
Ensembl chr11:91,226,180...91,240,169

G

allograft inflammatory factor 1

multiple interactions
decreases expression

ISO

3-((3,5-bis(trifluoromethyl)phenyl)methyloxy)-2-phenylpiperidine inhibits the reaction [norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased expression of AIF1 protein]]]]; ginsenoside Re affects the reaction [GPX1 protein affects the expression of AIF1 protein]; ginsenoside Re inhibits the reaction [Methamphetamine results in increased expression of AIF1 protein]; ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased expression of AIF1 protein]]; norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased expression of AIF1 protein]]]
ginsenoside Re results in decreased expression of AIF1 protein

PMID:29467000 PMID:36682417

NCBI chr20:3,651,435...3,657,341
Ensembl chr20:3,652,243...3,657,339

G

AKT serine/threonine kinase 1

multiple interactions
increases phosphorylation

ISO
EXP

ginsenoside Re results in increased phosphorylation of and results in increased activity of AKT1 protein
ginsenoside Re results in increased phosphorylation of AKT1 protein

PMID:17878692 PMID:17885204 PMID:24599032

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

androgen receptor

multiple interactions

ISO

ginsenoside Re binds to and affects the activity of AR protein

NCBI chr X:67,135,317...67,304,476
Ensembl chr X:67,135,317...67,304,467

G

activating transcription factor 6

multiple interactions

ISO

Deoxyglucose inhibits the reaction [ginsenoside Re inhibits the reaction [Glucose results in increased expression of ATF6 mRNA]]; Deoxyglucose inhibits the reaction [ginsenoside Re inhibits the reaction [Glucose results in increased expression of ATF6 protein]]; ginsenoside Re inhibits the reaction [Glucose results in increased expression of ATF6 mRNA]; ginsenoside Re inhibits the reaction [Glucose results in increased expression of ATF6 protein]

NCBI chr13:85,460,312...85,639,959
Ensembl chr13:85,462,840...85,640,033

G

BCL2 associated X, apoptosis regulator

decreases expression
multiple interactions

ISO
EXP

ginsenoside Re results in decreased expression of BAX mRNA; ginsenoside Re results in decreased expression of BAX protein
DDIT3 protein inhibits the reaction [ginsenoside Re inhibits the reaction [Glucose results in increased expression of BAX protein]]; Deoxyglucose inhibits the reaction [ginsenoside Re inhibits the reaction [Glucose results in increased expression of BAX protein]]; ginsenoside Re inhibits the reaction [Glucose results in increased expression of BAX protein]
3-((3,5-bis(trifluoromethyl)phenyl)methyloxy)-2-phenylpiperidine inhibits the reaction [norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased expression of BAX protein]]]]; Acetylcysteine inhibits the reaction [ginsenoside Re inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased expression of BAX protein]]; Cyclosporine inhibits the reaction [ginsenoside Re inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased expression of BAX protein]]; ginsenoside Re inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased expression of BAX protein]; ginsenoside Re inhibits the reaction [Methamphetamine results in increased expression of BAX protein]; ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased expression of BAX protein]]; norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased expression of BAX protein]]]

PMID:12674765 PMID:15621629 PMID:29467000 PMID:37308051 PMID:39798073

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

increases expression
multiple interactions

ISO

ginsenoside Re results in increased expression of BCL2 mRNA; ginsenoside Re results in increased expression of BCL2 protein
DDIT3 protein inhibits the reaction [ginsenoside Re inhibits the reaction [Glucose results in decreased expression of BCL2 protein]]; Deoxyglucose inhibits the reaction [ginsenoside Re inhibits the reaction [Glucose results in decreased expression of BCL2 protein]]; ginsenoside Re inhibits the reaction [Glucose results in decreased expression of BCL2 protein]
3-((3,5-bis(trifluoromethyl)phenyl)methyloxy)-2-phenylpiperidine inhibits the reaction [norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in decreased expression of BCL2 protein]]]]; 3-nitropropionic acid inhibits the reaction [ginsenoside Re inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in decreased expression of BCL2 protein]]; ginsenoside Re inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in decreased expression of BCL2 protein]; ginsenoside Re inhibits the reaction [Methamphetamine results in decreased expression of BCL2 protein]; ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in decreased expression of BCL2 protein]]; norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in decreased expression of BCL2 protein]]]

PMID:15621629 PMID:29467000 PMID:37308051 PMID:39798073

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

Bcl2-like 1

multiple interactions

ISO

3-nitropropionic acid inhibits the reaction [ginsenoside Re inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in decreased expression of BCL2L1 protein]]; ginsenoside Re inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in decreased expression of BCL2L1 protein]

NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907

G

caspase 3

multiple interactions

ISO

3-((3,5-bis(trifluoromethyl)phenyl)methyloxy)-2-phenylpiperidine inhibits the reaction [norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased cleavage of CASP3 protein]]]]; 3-nitropropionic acid inhibits the reaction [ginsenoside Re inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased cleavage of CASP3 protein]]; ginsenoside Re inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased cleavage of CASP3 protein]; ginsenoside Re inhibits the reaction [Lipopolysaccharides results in increased activity of CASP3 protein]; ginsenoside Re inhibits the reaction [Methamphetamine results in increased cleavage of CASP3 protein]; ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased cleavage of CASP3 protein]]; ginsenoside Re results in decreased cleavage of and results in decreased activity of CASP3 protein; norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased cleavage of CASP3 protein]]]
DDIT3 protein inhibits the reaction [ginsenoside Re inhibits the reaction [Glucose results in increased cleavage of CASP3 protein]]; Deoxyglucose inhibits the reaction [ginsenoside Re inhibits the reaction [Glucose results in increased cleavage of CASP3 protein]]; ginsenoside Re inhibits the reaction [Glucose results in increased cleavage of CASP3 protein]; ginsenoside Re inhibits the reaction [Methamphetamine results in increased cleavage of CASP3 protein]

PMID:15621629 PMID:23102375 PMID:25523949 PMID:29467000 PMID:37308051 More...

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

catalase

multiple interactions

ISO

ginsenoside Re inhibits the reaction [Methamphetamine results in increased activity of CAT protein]; PRKCD affects the reaction [ginsenoside Re inhibits the reaction [Methamphetamine results in increased activity of CAT protein]]

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

cyclin-dependent kinase inhibitor 1A

increases expression

ISO

ginsenoside Re results in increased expression of CDKN1A mRNA

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

choline O-acetyltransferase

increases expression
multiple interactions

ISO

ginsenoside Re results in increased expression of CHAT mRNA; ginsenoside Re results in increased expression of CHAT protein
staurosporine aglycone inhibits the reaction [ginsenoside Re results in increased expression of CHAT mRNA]; staurosporine aglycone inhibits the reaction [ginsenoside Re results in increased expression of CHAT protein]

NCBI chr16:7,663,665...7,723,416
Ensembl chr16:7,663,665...7,723,416

G

component of inhibitor of nuclear factor kappa B kinase complex

multiple interactions

ISO

ginsenoside Re inhibits the reaction [TNF protein results in increased phosphorylation of CHUK protein]

NCBI chr 1:252,908,748...252,944,273
Ensembl chr 1:252,908,749...252,944,273

G

claudin 1

multiple interactions

ISO

ginsenoside Re inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of CLDN1 protein]

NCBI chr11:87,926,376...87,941,533
Ensembl chr11:87,926,337...87,941,529

G

C-reactive protein

increases expression

EXP

ginsenoside Re results in increased expression of CRP protein

NCBI chr13:87,694,062...87,695,978
Ensembl chr13:87,657,317...87,707,514

G

cytochrome b-245 alpha chain

multiple interactions

ISO

ginsenoside Re inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in increased activity of CYBA protein]]; ginsenoside Re inhibits the reaction [Phencyclidine results in increased activity of CYBA protein]

NCBI chr19:67,396,143...67,404,214
Ensembl chr19:67,396,143...67,404,214

G

cytochrome P450 family 8 subfamily B member 1

increases expression

EXP

ginsenoside Re results in increased expression of CYP8B1 mRNA

NCBI chr 8:130,455,622...130,457,592
Ensembl chr 8:130,442,503...130,457,689

G

DNA-damage inducible transcript 3

multiple interactions

ISO

DDIT3 protein inhibits the reaction [ginsenoside Re inhibits the reaction [Glucose results in decreased expression of BCL2 protein]]; DDIT3 protein inhibits the reaction [ginsenoside Re inhibits the reaction [Glucose results in increased cleavage of CASP3 protein]]; DDIT3 protein inhibits the reaction [ginsenoside Re inhibits the reaction [Glucose results in increased expression of BAX protein]]; Deoxyglucose inhibits the reaction [ginsenoside Re inhibits the reaction [Glucose results in increased expression of DDIT3 mRNA]]; ginsenoside Re inhibits the reaction [Glucose results in increased expression of DDIT3 mRNA]; ginsenoside Re inhibits the reaction [Glucose results in increased expression of DDIT3 protein]

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509

G

eukaryotic translation initiation factor 2 alpha kinase 3

multiple interactions

ISO

Deoxyglucose inhibits the reaction [ginsenoside Re inhibits the reaction [Glucose results in increased phosphorylation of EIF2AK3 protein]]; ginsenoside Re inhibits the reaction [Glucose results in increased phosphorylation of EIF2AK3 protein]

NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:104,363,833...104,425,268

G

endoplasmic reticulum to nucleus signaling 1

multiple interactions

ISO

Deoxyglucose inhibits the reaction [ginsenoside Re inhibits the reaction [Glucose results in increased phosphorylation of ERN1 protein]]; ginsenoside Re inhibits the reaction [Glucose results in increased phosphorylation of ERN1 protein]

NCBI chr10:91,826,663...91,920,976
Ensembl chr10:91,830,428...91,920,791

G

estrogen receptor 1

multiple interactions

ISO

ginsenoside Re binds to and affects the activity of ESR1 protein

NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354

G

fatty acid binding protein 4

increases expression

ISO

ginsenoside Re results in increased expression of FABP4 mRNA

NCBI chr 2:93,488,251...93,492,961
Ensembl chr 2:93,488,271...93,492,972

G

Fas cell surface death receptor

decreases expression
multiple interactions

ISO

ginsenoside Re results in decreased expression of FAS mRNA
ginsenoside Re inhibits the reaction [Dietary Fats results in increased expression of FAS mRNA]

NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression

ISO

ginsenoside Re results in increased expression of FOS mRNA

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598

G

glucose-6-phosphatase catalytic subunit 1

decreases expression

ISO

ginsenoside Re results in decreased expression of G6PC1 mRNA

NCBI chr10:86,807,659...86,819,023
Ensembl chr10:86,757,899...86,818,033

G

growth arrest and DNA-damage-inducible, gamma

multiple interactions

ISO

Deoxyglucose inhibits the reaction [ginsenoside Re inhibits the reaction [Glucose results in increased expression of GADD45G protein]]

NCBI chr17:13,528,606...13,530,351
Ensembl chr17:13,528,610...13,530,369

G

glycerol-3-phosphate acyltransferase, mitochondrial

multiple interactions

ISO

ginsenoside Re inhibits the reaction [Dietary Fats results in increased expression of GPAM mRNA]

NCBI chr 1:264,111,599...264,176,112
Ensembl chr 1:264,113,813...264,175,911

G

glutathione peroxidase 1

multiple interactions

ISO

ginsenoside Re affects the reaction [GPX1 protein affects the expression of AIF1 protein]; ginsenoside Re affects the reaction [GPX1 protein affects the expression of and affects the localization of RELA protein]; ginsenoside Re affects the reaction [GPX1 protein affects the expression of PTAFR protein]; ginsenoside Re affects the reaction [GPX1 protein affects the phosphorylation of MAPK1 protein]; ginsenoside Re affects the reaction [GPX1 protein affects the phosphorylation of MAPK3 protein]; ginsenoside Re inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine affects the localization of NCF1 protein]]; ginsenoside Re inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in decreased activity of SOD2 protein]]; ginsenoside Re inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in increased activity of CYBA protein]]; ginsenoside Re inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in increased activity of SOD1 protein]]

PMID:29037473 PMID:36682417

NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581

G

glycogen synthase kinase 3 beta

increases phosphorylation

ISO

ginsenoside Re results in increased phosphorylation of GSK3B protein

NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249

G

heat shock protein family D (Hsp60) member 1

increases expression

ISO

ginsenoside Re results in increased expression of HSPD1 protein

NCBI chr 9:64,073,610...64,084,332
Ensembl chr 9:64,073,611...64,084,037

G

interferon gamma

decreases expression

ISO

ginsenoside Re results in decreased expression of IFNG protein

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

inhibitor of nuclear factor kappa B kinase subunit beta

multiple interactions

ISO

ginsenoside Re inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IKBKB protein]

NCBI chr16:76,021,968...76,075,717
Ensembl chr16:76,022,008...76,081,911

G

interleukin 1 beta

multiple interactions

ISO

ginsenoside Re inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; ginsenoside Re inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; ginsenoside Re metabolite inhibits the reaction [Oxazolone results in increased expression of IL1B mRNA]; ginsenoside Re metabolite inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL1B mRNA]

PMID:16557482 PMID:22494059 PMID:22849695

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 6

multiple interactions

ISO

ginsenoside Re inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

insulin 1

multiple interactions

EXP

ginsenoside Re inhibits the reaction [Dietary Fats inhibits the reaction [INS1 protein results in increased localization of SLC2A4 protein]]

NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682

G

interleukin-1 receptor-associated kinase 1

multiple interactions

ISO

ginsenoside Re inhibits the reaction [Lipopolysaccharides results in increased degradation of IRAK1 protein]; ginsenoside Re inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IRAK1 protein]

NCBI chr X:156,919,927...156,929,825
Ensembl chr X:156,920,081...156,929,825

G

interleukin-1 receptor-associated kinase 4

multiple interactions

ISO

ginsenoside Re inhibits the reaction [Lipopolysaccharides results in increased degradation of IRAK4 protein]

NCBI chr 7:127,561,777...127,588,762
Ensembl chr 7:127,561,717...127,597,109

G

immunity-related GTPase M

decreases expression

ISO

ginsenoside Re results in decreased expression of IRGM protein

NCBI chr10:33,734,640...33,742,720
Ensembl chr10:33,732,961...33,743,228

G

insulin receptor substrate 1

multiple interactions
increases expression
increases phosphorylation

ISO

ginsenoside Re inhibits the reaction [TNF protein results in increased phosphorylation of IRS1 protein]
ginsenoside Re results in increased expression of IRS1 mRNA
ginsenoside Re results in increased phosphorylation of IRS1 protein

PMID:17885204 PMID:23545455

NCBI chr 9:91,001,137...91,053,959
Ensembl chr 9:90,993,519...91,054,538

G

potassium voltage-gated channel subfamily E regulatory subunit 1

increases expression

ISO

ginsenoside Re results in increased expression of KCNE1

NCBI chr11:45,066,875...45,080,024
Ensembl chr11:45,064,162...45,081,247

G

lipoprotein lipase

increases secretion

ISO

ginsenoside Re results in increased secretion of LPL protein

NCBI chr16:25,596,205...25,621,928
Ensembl chr16:25,596,211...25,622,107

G

leucine-rich pentatricopeptide repeat containing

increases expression

ISO

ginsenoside Re results in increased expression of LRPPRC protein

NCBI chr 6:15,612,638...15,695,113
Ensembl chr 6:15,612,655...15,695,116

G

microtubule-associated protein 2

increases expression

ISO

ginsenoside Re results in increased expression of MAP2 mRNA; ginsenoside Re results in increased expression of MAP2 protein

NCBI chr 9:75,173,038...75,431,606
Ensembl chr 9:75,288,262...75,428,459

G

mitogen activated protein kinase 1

multiple interactions
increases phosphorylation

ISO

ginsenoside Re affects the reaction [GPX1 protein affects the phosphorylation of MAPK1 protein]; ginsenoside Re results in increased phosphorylation of and results in increased activity of MAPK1 protein
ginsenoside Re results in increased phosphorylation of MAPK1 protein

PMID:24599032 PMID:36682417

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

multiple interactions
increases phosphorylation

ISO

ginsenoside Re affects the reaction [GPX1 protein affects the phosphorylation of MAPK3 protein]; ginsenoside Re results in increased phosphorylation of and results in increased activity of MAPK3 protein
ginsenoside Re results in increased phosphorylation of MAPK3 protein

PMID:24599032 PMID:36682417

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

myeloperoxidase

multiple interactions

ISO

ginsenoside Re inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056

G

myosin light chain 9

affects phosphorylation

EXP

ginsenoside Re affects the phosphorylation of MYL9 protein

NCBI chr 3:165,742,020...165,748,409
Ensembl chr 3:165,742,046...165,748,410

G

myosin light chain kinase

affects expression

EXP

ginsenoside Re affects the expression of MYLK mRNA; ginsenoside Re affects the expression of MYLK protein

NCBI chr11:79,288,243...79,535,450
Ensembl chr11:79,288,243...79,535,659

G

neutrophil cytosolic factor 1

multiple interactions

ISO

ginsenoside Re inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine affects the localization of NCF1 protein]]; ginsenoside Re inhibits the reaction [Phencyclidine affects the localization of NCF1 protein]

NCBI chr12:28,121,816...28,131,080
Ensembl chr12:28,121,366...28,131,079

G

NFKB inhibitor alpha

multiple interactions

ISO
EXP

ginsenoside Re inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072

G

nerve growth factor

increases expression

ISO

ginsenoside Re results in increased expression of NGF mRNA

NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:192,589,582...192,643,834

G

nerve growth factor receptor

increases expression

ISO

ginsenoside Re results in increased expression of NGFR mRNA; ginsenoside Re results in increased expression of NGFR protein

NCBI chr10:81,012,077...81,030,305
Ensembl chr10:81,012,089...81,030,305

G

nitric oxide synthase 2

multiple interactions
decreases expression

ISO

ginsenoside Re inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
ginsenoside Re results in decreased expression of NOS2 protein

PMID:15621629 PMID:23102375

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

nitric oxide synthase 3

multiple interactions
increases phosphorylation

ISO

2-aminoethoxydiphenyl borate inhibits the reaction [ginsenoside Re results in increased phosphorylation of NOS3 protein]; Calcium deficiency inhibits the reaction [ginsenoside Re results in increased phosphorylation of NOS3 protein]; Mifepristone inhibits the reaction [ginsenoside Re results in increased phosphorylation of NOS3 protein]

NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664

G

nuclear receptor subfamily 0, group B, member 2

increases expression

ISO

ginsenoside Re results in increased expression of NR0B2 mRNA

NCBI chr 5:151,063,160...151,066,475
Ensembl chr 5:151,063,160...151,066,475

G

nuclear receptor subfamily 3, group C, member 1

multiple interactions
increases activity

ISO

[ginsenoside Re results in increased activity of NR3C1 protein] which results in increased abundance of Nitric Oxide

NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,522,783...31,643,843

G

occludin

multiple interactions

ISO

ginsenoside Re inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of OCLN protein]

NCBI chr 2:33,391,303...33,442,207
Ensembl chr 2:33,391,303...33,430,411

G

poly (ADP-ribose) polymerase 1

multiple interactions

ISO

ginsenoside Re inhibits the reaction [Methamphetamine results in increased cleavage of PARP1 protein]

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

phosphoenolpyruvate carboxykinase 1

multiple interactions
decreases expression

ISO

ginsenoside Re inhibits the reaction [Dietary Fats results in increased expression of PCK1 mRNA]
ginsenoside Re results in decreased expression of PCK1 mRNA

NCBI chr 3:182,348,572...182,354,521
Ensembl chr 3:182,348,572...182,354,561

G

prodynorphin

multiple interactions

ISO

3-((3,5-bis(trifluoromethyl)phenyl)methyloxy)-2-phenylpiperidine inhibits the reaction [norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in decreased expression of BCL2 protein]]]]; 3-((3,5-bis(trifluoromethyl)phenyl)methyloxy)-2-phenylpiperidine inhibits the reaction [norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in decreased expression of TH protein]]]]; 3-((3,5-bis(trifluoromethyl)phenyl)methyloxy)-2-phenylpiperidine inhibits the reaction [norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased cleavage of CASP3 protein]]]]; 3-((3,5-bis(trifluoromethyl)phenyl)methyloxy)-2-phenylpiperidine inhibits the reaction [norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased expression of AIF1 protein]]]]; 3-((3,5-bis(trifluoromethyl)phenyl)methyloxy)-2-phenylpiperidine inhibits the reaction [norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased expression of BAX protein]]]]; ginsenoside Re inhibits the reaction [Methamphetamine results in decreased expression of PDYN mRNA]; ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in decreased expression of BCL2 protein]]; ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in decreased expression of TH protein]]; ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased cleavage of CASP3 protein]]; ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased expression of AIF1 protein]]; ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased expression of BAX protein]]; norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in decreased expression of BCL2 protein]]]; norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in decreased expression of TH protein]]]; norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased cleavage of CASP3 protein]]]; norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased expression of AIF1 protein]]]; norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased expression of BAX protein]]]

NCBI chr 3:137,354,161...137,366,503
Ensembl chr 3:137,354,161...137,366,503

G

progesterone receptor

multiple interactions
increases expression

ISO

ginsenoside Re binds to and affects the activity of PGR protein
ginsenoside Re results in increased expression of PGR protein

PMID:16204943 PMID:16985185

NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:14,354,398...14,413,271

G

peroxisome proliferator-activated receptor gamma

increases expression

ISO

ginsenoside Re results in increased expression of PPARG mRNA

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104

G

protein kinase AMP-activated catalytic subunit alpha 1

increases phosphorylation
multiple interactions

ISO

ginsenoside Re results in increased phosphorylation of PRKAA1 protein
ginsenoside Re inhibits the reaction [Dietary Fats results in decreased phosphorylation of PRKAA1 protein]

NCBI chr 2:55,967,766...56,003,450
Ensembl chr 2:55,967,351...56,003,450

G

protein kinase C, delta

multiple interactions
increases response to substance

ISO

3-nitropropionic acid inhibits the reaction [ginsenoside Re inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased cleavage of and results in increased phosphorylation of PRKCD protein]]; ginsenoside Re inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased cleavage of and results in increased phosphorylation of PRKCD protein]; ginsenoside Re inhibits the reaction [Methamphetamine affects the localization of PRKCD protein]; PRKCD affects the reaction [ginsenoside Re inhibits the reaction [Methamphetamine results in increased activity of CAT protein]]; PRKCD affects the reaction [ginsenoside Re inhibits the reaction [Methamphetamine results in increased activity of SOD1 protein]]
ginsenoside Re inhibits the reaction [Methamphetamine affects the localization of PRKCD protein]; ginsenoside Re inhibits the reaction [Methamphetamine results in increased expression of and results in increased cleavage of PRKCD protein]
PRKCD results in increased susceptibility to ginsenoside Re

PMID:24430743 PMID:25523949 PMID:37308051

NCBI chr16:5,775,681...5,806,122
Ensembl chr16:5,775,681...5,805,839

G

platelet-activating factor receptor

multiple interactions
decreases expression

ISO

ginsenoside Re affects the reaction [GPX1 protein affects the expression of PTAFR protein]
ginsenoside Re results in decreased expression of PTAFR protein

NCBI chr 5:150,049,322...150,079,060
Ensembl chr 5:150,049,460...150,079,408

G

prostaglandin-endoperoxide synthase 2

multiple interactions

ISO

ginsenoside Re inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; ginsenoside Re metabolite inhibits the reaction [Oxazolone results in increased expression of PTGS2 mRNA]; ginsenoside Re metabolite inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 mRNA]

PMID:16557482 PMID:23102375

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

ISO

ginsenoside Re affects the reaction [GPX1 protein affects the expression of and affects the localization of RELA protein]; ginsenoside Re results in decreased expression of and affects the localization of RELA protein

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

ribosomal protein S6 kinase B1

increases phosphorylation

ISO

ginsenoside Re results in increased phosphorylation of RPS6KB1 protein

NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,815,614...71,865,238

G

stearoyl-CoA desaturase

decreases expression
multiple interactions

ISO

ginsenoside Re results in decreased expression of SCD mRNA
ginsenoside Re inhibits the reaction [Dietary Fats results in increased expression of SCD1 mRNA]

NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:253,218,970...253,231,785

G

solute carrier family 18 member A3

increases expression

ISO

ginsenoside Re results in increased expression of SLC18A3 mRNA

NCBI chr16:7,719,953...7,722,814

G

solute carrier family 2 member 4

multiple interactions
increases localization

EXP
ISO

ginsenoside Re inhibits the reaction [Dietary Fats inhibits the reaction [INS1 protein results in increased localization of SLC2A4 protein]]
ginsenoside Re results in increased localization of SLC2A4 protein

PMID:17885204 PMID:22571876 PMID:23545455

NCBI chr10:55,164,721...55,170,289
Ensembl chr10:55,164,721...55,170,270

G

solute carrier family 5 member 7

increases expression

ISO

ginsenoside Re results in increased expression of SLC5A7 mRNA

NCBI chr 9:7,922,693...7,953,509
Ensembl chr 9:7,922,697...7,953,509

G

solute carrier organic anion transporter family member 1B2

multiple interactions

EXP
ISO

SLCO1B2 protein binds to and results in increased transport of ginsenoside Re
SLCO1B3 protein binds to and results in increased transport of ginsenoside Re

NCBI chr 4:176,282,577...176,355,557
Ensembl chr 4:176,282,584...176,351,083

G

suppressor of cytokine signaling 3

multiple interactions

ISO

ginsenoside Re inhibits the reaction [TNF protein results in increased expression of SOCS3 mRNA]

NCBI chr10:103,692,579...103,695,975
Ensembl chr10:103,690,976...103,704,825

G

superoxide dismutase 1

multiple interactions
decreases activity

ISO

ginsenoside Re inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in increased activity of SOD1 protein]]; ginsenoside Re inhibits the reaction [Methamphetamine results in increased activity of SOD1 protein]; PRKCD affects the reaction [ginsenoside Re inhibits the reaction [Methamphetamine results in increased activity of SOD1 protein]]
ginsenoside Re results in decreased activity of SOD1 protein

PMID:24430743 PMID:29037473 PMID:36682417

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399

G

superoxide dismutase 2

multiple interactions

ISO

ginsenoside Re inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in decreased activity of SOD2 protein]; ginsenoside Re inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in decreased activity of SOD2 protein]]

PMID:29037473 PMID:37308051

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168

G

sterol regulatory element binding transcription factor 1

multiple interactions
decreases expression

ISO

ginsenoside Re inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]
ginsenoside Re results in decreased expression of SREBF1 mRNA

NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,507,152...45,529,164

G

serine/threonine kinase 11

increases phosphorylation

ISO

ginsenoside Re results in increased phosphorylation of STK11 protein

NCBI chr 7:10,225,204...10,241,965
Ensembl chr 7:10,225,204...10,241,965

G

tachykinin, precursor 1

multiple interactions

ISO

ginsenoside Re inhibits the reaction [Methamphetamine results in increased expression of TAC1 mRNA]; ginsenoside Re inhibits the reaction [Methamphetamine results in increased expression of TAC1 protein modified form]; norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [Methamphetamine results in increased expression of TAC1 mRNA]]; norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [Methamphetamine results in increased expression of TAC1 protein modified form]]

NCBI chr 4:36,645,344...36,653,548
Ensembl chr 4:36,645,571...36,653,546

G

TBC1 domain family, member 4

increases phosphorylation

ISO

ginsenoside Re results in increased phosphorylation of TBC1D4 protein

NCBI chr15:84,670,756...84,848,876
Ensembl chr15:84,670,756...84,848,693

G

trefoil factor 1

increases expression

ISO

ginsenoside Re results in increased expression of TFF1 mRNA

NCBI chr20:9,237,095...9,240,956
Ensembl chr20:9,237,095...9,240,956

G

tyrosine hydroxylase

multiple interactions

ISO

ginsenoside Re inhibits the reaction [Methamphetamine results in decreased expression of and results in decreased activity of TH protein]
3-((3,5-bis(trifluoromethyl)phenyl)methyloxy)-2-phenylpiperidine inhibits the reaction [norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in decreased expression of TH protein]]]]; ginsenoside Re inhibits the reaction [Methamphetamine results in decreased expression of TH protein]; ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in decreased expression of TH protein]]; norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in decreased expression of TH protein]]]

PMID:25523949 PMID:29467000

NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:207,500,962...207,557,227

G

tight junction protein 1

multiple interactions

ISO

ginsenoside Re inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of TJP1 protein]

NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:128,260,330...128,505,158

G

toll-like receptor 4

multiple interactions

ISO

ginsenoside Re inhibits the reaction [Lipopolysaccharides binds to TLR4 protein]

NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007

G

tumor necrosis factor

multiple interactions

ISO
EXP

ginsenoside Re inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; ginsenoside Re inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; ginsenoside Re inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; ginsenoside Re inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]; ginsenoside Re inhibits the reaction [TNF protein results in increased expression of SOCS3 mRNA]; ginsenoside Re inhibits the reaction [TNF protein results in increased phosphorylation of CHUK protein]; ginsenoside Re inhibits the reaction [TNF protein results in increased phosphorylation of IRS1 protein]; ginsenoside Re metabolite inhibits the reaction [Oxazolone results in increased expression of TNF mRNA]; ginsenoside Re metabolite inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNF mRNA]; ginsenoside Re results in decreased expression of and results in decreased secretion of TNF protein

PMID:16557482 PMID:17885204 PMID:22494059 PMID:22849695 PMID:23545455

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

apolipoprotein A1

multiple interactions
decreases expression

ISO

ginsenoside Rf inhibits the reaction [pirinixic acid results in decreased expression of APOA1 mRNA]; ginsenoside Rf inhibits the reaction [pirinixic acid results in decreased expression of APOA1 protein]; PPARA protein affects the reaction [ginsenoside Rf inhibits the reaction [pirinixic acid results in decreased expression of APOA1 mRNA]]
ginsenoside Rf results in decreased expression of APOA1 protein

NCBI chr 8:55,423,945...55,425,729
Ensembl chr 8:55,423,825...55,425,729

G

apolipoprotein C3

multiple interactions
decreases expression
increases expression

ISO

ginsenoside Rf inhibits the reaction [pirinixic acid results in decreased expression of APOC3 mRNA]; ginsenoside Rf inhibits the reaction [pirinixic acid results in decreased expression of APOC3 protein]; PPARA protein affects the reaction [ginsenoside Rf inhibits the reaction [pirinixic acid results in decreased expression of APOC3 mRNA]]; PPARA protein affects the reaction [ginsenoside Rf results in increased expression of APOC3 mRNA]
ginsenoside Rf results in decreased expression of APOC3 protein

NCBI chr 8:55,428,172...55,430,352
Ensembl chr 8:55,428,024...55,458,679

G

potassium voltage-gated channel subfamily H member 2

affects activity

ISO

ginsenoside Rf affects the activity of KCNH2 protein

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421

G

peroxisome proliferator activated receptor alpha

multiple interactions
decreases expression

ISO

ginsenoside Rf binds to and results in decreased activity of PPARA protein; ginsenoside Rf inhibits the reaction [pirinixic acid results in increased activity of PPARA protein]; ginsenoside Rf inhibits the reaction [pirinixic acid results in increased expression of PPARA mRNA]; PPARA protein affects the reaction [ginsenoside Rf inhibits the reaction [pirinixic acid results in decreased expression of APOA1 mRNA]]; PPARA protein affects the reaction [ginsenoside Rf inhibits the reaction [pirinixic acid results in decreased expression of APOC3 mRNA]]; PPARA protein affects the reaction [ginsenoside Rf results in increased expression of APOC3 mRNA]
ginsenoside Rf results in decreased expression of PPARA mRNA

NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714

ginsenoside Rg1

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

increases transport
multiple interactions

EXP
ISO

ABCB11 protein results in increased transport of ginsenoside Rg1
ginsenoside Rg1 inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of ABCB11 mRNA]; ginsenoside Rg1 inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of ABCB11 protein]
ginsenoside Rg1 promotes the reaction [Carbon Tetrachloride results in increased expression of ABCB11 protein]

PMID:25297453 PMID:29964319 PMID:32198087

NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581

G

ATP binding cassette subfamily C member 1

increases transport

ISO

ABCC1 protein results in increased transport of ginsenoside Rg1

NCBI chr10:1,022,041...1,162,431
Ensembl chr10:1,038,947...1,162,404

G

ATP binding cassette subfamily C member 2

increases transport
multiple interactions
increases expression

EXP
ISO

ABCC2 protein results in increased transport of ginsenoside Rg1
ginsenoside Rg1 inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of ABCC2 mRNA]; ginsenoside Rg1 inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of ABCC2 protein]
ginsenoside Rg1 promotes the reaction [Carbon Tetrachloride results in increased expression of ABCC2 protein]; Tretinoin inhibits the reaction [ginsenoside Rg1 promotes the reaction [Carbon Tetrachloride results in increased expression of ABCC2 protein]]
ginsenoside Rg1 results in increased expression of ABCC2 protein

PMID:25297453 PMID:29964319 PMID:32198087

NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471

G

ATP binding cassette subfamily C member 3

increases expression
multiple interactions

ISO

ginsenoside Rg1 results in increased expression of ABCC3 protein
ginsenoside Rg1 promotes the reaction [Carbon Tetrachloride results in increased expression of ABCC3 protein]; Tretinoin inhibits the reaction [ginsenoside Rg1 promotes the reaction [Carbon Tetrachloride results in increased expression of ABCC3 protein]]

NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,793,583...79,839,494

G

ATP binding cassette subfamily C member 4

increases expression
multiple interactions

ISO

ginsenoside Rg1 results in increased expression of ABCC4 protein
ginsenoside Rg1 promotes the reaction [Carbon Tetrachloride results in increased expression of ABCC4 protein]

NCBI chr15:101,948,387...102,182,912
Ensembl chr15:101,949,433...102,181,375

G

ATP binding cassette subfamily G member 2

increases transport

EXP
ISO

ABCG2 protein results in increased transport of ginsenoside Rg1

NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:89,005,969...89,132,493

G

acetylcholinesterase

decreases activity

ISO

ginsenoside Rg1 results in decreased activity of ACHE protein

NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410

G

ADAM metallopeptidase domain 10

multiple interactions

EXP

ginsenoside Rg1 inhibits the reaction [[APP protein alternative form co-treated with Dexamethasone] results in decreased expression of ADAM10 mRNA]

NCBI chr 8:80,226,862...80,358,728
Ensembl chr 8:80,226,674...80,361,600

G

AKT serine/threonine kinase 1

multiple interactions

ISO
EXP

ginsenoside Rg1 inhibits the reaction [Chlorpyrifos results in decreased phosphorylation of AKT1 protein]; ginsenoside Rg1 inhibits the reaction [Dibutyl Phthalate results in decreased expression of AKT1 mRNA]; ginsenoside Rg1 inhibits the reaction [Dibutyl Phthalate results in decreased phosphorylation of AKT1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in decreased phosphorylation of AKT1 protein]]; ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in decreased phosphorylation of AKT1 protein]
ginsenoside Rg1 inhibits the reaction [Doxorubicin results in increased expression of AKT1 mRNA]

PMID:33331133 PMID:34783124 PMID:34859534 PMID:36811218

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

apoptotic peptidase activating factor 1

multiple interactions

ISO

ginsenoside Rg1 promotes the reaction [Doxorubicin results in increased expression of APAF1 mRNA]

NCBI chr 7:27,381,392...27,466,772
Ensembl chr 7:27,381,855...27,466,772

G

amyloid beta precursor protein

multiple interactions

EXP

ginsenoside Rg1 inhibits the reaction [[APP protein alternative form co-treated with Dexamethasone] results in decreased expression of ADAM10 mRNA]; ginsenoside Rg1 inhibits the reaction [[APP protein alternative form co-treated with Dexamethasone] results in increased expression of APP mRNA]; ginsenoside Rg1 inhibits the reaction [[APP protein alternative form co-treated with Dexamethasone] results in increased expression of APP protein alternative form]; ginsenoside Rg1 inhibits the reaction [[APP protein alternative form co-treated with Dexamethasone] results in increased expression of APP protein]; ginsenoside Rg1 inhibits the reaction [[APP protein alternative form co-treated with Dexamethasone] results in increased expression of BACE1 mRNA]; ginsenoside Rg1 results in decreased susceptibility to [APP protein alternative form co-treated with Dexamethasone]

NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971

G

activating transcription factor 6

multiple interactions

ISO

ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in increased expression of ATF6 protein]

NCBI chr13:85,460,312...85,639,959
Ensembl chr13:85,462,840...85,640,033

G

ATM serine/threonine kinase

multiple interactions

ISO

ginsenoside Rg1 promotes the reaction [Doxorubicin results in increased expression of ATM mRNA]

NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:62,727,291...62,828,629

G

beta-secretase 1

multiple interactions

EXP

ginsenoside Rg1 inhibits the reaction [[APP protein alternative form co-treated with Dexamethasone] results in increased expression of BACE1 mRNA]

NCBI chr 8:55,038,842...55,061,138
Ensembl chr 8:55,038,823...55,064,918

G

BCL2-associated agonist of cell death

multiple interactions

EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rg1 inhibits the reaction [Rotenone results in increased phosphorylation of BAD protein]]; ginsenoside Rg1 inhibits the reaction [Rotenone results in increased phosphorylation of BAD protein]; Mifepristone inhibits the reaction [ginsenoside Rg1 inhibits the reaction [Rotenone results in increased phosphorylation of BAD protein]]; SH-6 compound inhibits the reaction [ginsenoside Rg1 inhibits the reaction [Rotenone results in increased phosphorylation of BAD protein]]

NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:213,562,187...213,572,034

G

BCL2 associated X, apoptosis regulator

increases expression
multiple interactions

ISO
EXP

ginsenoside Rg1 results in increased expression of BAX protein
ginsenoside Rg1 inhibits the reaction [Chlorpyrifos results in increased expression of BAX protein]
ginsenoside Rg1 promotes the reaction [Doxorubicin results in increased expression of BAX mRNA]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]]; ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]

PMID:28371286 PMID:34783124 PMID:34859534 PMID:36811218

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

decreases expression
multiple interactions

ISO
EXP

ginsenoside Rg1 results in decreased expression of BCL2 protein
ginsenoside Rg1 inhibits the reaction [Chlorpyrifos results in decreased expression of BCL2 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]]; ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]; ginsenoside Rg1 inhibits the reaction [Oxygen deficiency results in decreased expression of BCL2 protein]

PMID:26593335 PMID:28371286 PMID:34859534 PMID:36811218

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

caspase 3

multiple interactions
increases activity

ISO
EXP

ginsenoside Rg1 inhibits the reaction [cobaltous chloride results in increased activity of CASP3 protein]; ginsenoside Rg1 promotes the reaction [Doxorubicin results in increased expression of CASP3 mRNA]
ginsenoside Rg1 inhibits the reaction [Chlorpyrifos results in increased cleavage of CASP3 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP3 protein]]; ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP3 protein]
ginsenoside Rg1 results in increased activity of CASP3 protein

PMID:24386346 PMID:28371286 PMID:34783124 PMID:34859534 PMID:36811218

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 9

increases activity
multiple interactions

ISO
EXP

ginsenoside Rg1 results in increased activity of CASP9 protein
ginsenoside Rg1 inhibits the reaction [Chlorpyrifos results in increased cleavage of CASP9 protein]
ginsenoside Rg1 promotes the reaction [Doxorubicin results in increased expression of CASP9 mRNA]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP9 protein]]; ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP9 protein]

PMID:28371286 PMID:34783124 PMID:34859534 PMID:36811218

Ensembl chr 5:159,391,188...159,409,648

G

catalase

multiple interactions

ISO
EXP

ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein]
ginsenoside Rg1 inhibits the reaction [Oxygen deficiency results in decreased expression of CAT protein]

PMID:29964319 PMID:37923178

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

cyclin E1

multiple interactions

ISO

ginsenoside Rg1 affects the reaction [tert-Butylhydroperoxide affects the expression of CCNE1 protein]

NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:99,918,674...99,927,822

G

cadherin 1

multiple interactions

ISO

ginsenoside Rg1 inhibits the reaction [Dibutyl Phthalate results in decreased expression of CDH1 mRNA]; ginsenoside Rg1 inhibits the reaction [Dibutyl Phthalate results in decreased expression of CDH1 protein]

NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565

G

cyclin dependent kinase 2

multiple interactions

ISO

ginsenoside Rg1 affects the reaction [tert-Butylhydroperoxide affects the expression of CDK2 protein]

NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,714,392...1,721,878

G

cyclin-dependent kinase inhibitor 1A

multiple interactions

ISO

ginsenoside Rg1 affects the reaction [tert-Butylhydroperoxide affects the expression of CDKN1A protein]; ginsenoside Rg1 promotes the reaction [Doxorubicin results in increased expression of CDKN1A mRNA]

PMID:15606011 PMID:34783124

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

cAMP responsive element binding protein 1

multiple interactions

ISO

ginsenoside Rg1 inhibits the reaction [Dibutyl Phthalate results in decreased expression of CREB1 protein]

NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339

G

cytochrome P450, family 2, subfamily b, polypeptide 3

multiple interactions

EXP

ginsenoside Rg1 inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of CYP2B10 mRNA]; ginsenoside Rg1 inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of CYP2B10 protein]

NCBI chr 1:90,780,468...90,859,852

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions

ISO

ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in increased expression of CYP2E1 mRNA]

NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions

EXP

ginsenoside Rg1 inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of CYP3A4 mRNA]; ginsenoside Rg1 inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of CYP3A4 protein]

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

DNA-damage inducible transcript 3

multiple interactions

ISO

ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in increased expression of DDIT3 protein]

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509

G

endoplasmic reticulum to nucleus signaling 1

multiple interactions

ISO

ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in increased expression of ERN1 protein]

NCBI chr10:91,826,663...91,920,976
Ensembl chr10:91,830,428...91,920,791

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression

ISO

ginsenoside Rg1 results in increased expression of FOS mRNA

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598

G

follicle stimulating hormone subunit beta

multiple interactions

ISO

ginsenoside Rg1 inhibits the reaction [Dibutyl Phthalate results in increased expression of FSHB protein]

NCBI chr 3:114,003,262...114,007,072
Ensembl chr 3:114,003,262...114,007,072

G

follicle stimulating hormone receptor

multiple interactions

ISO

ginsenoside Rg1 inhibits the reaction [Dibutyl Phthalate results in decreased expression of FSHR protein]

NCBI chr 6:10,952,329...11,160,288
Ensembl chr 6:10,952,329...11,160,288

G

glutamate-cysteine ligase, catalytic subunit

increases expression
multiple interactions

ISO

ginsenoside Rg1 results in increased expression of GCLC mRNA
ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLC mRNA]; NFE2L2 protein affects the reaction [ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLC mRNA]]

NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893

G

glutamate cysteine ligase, modifier subunit

increases expression
multiple interactions

ISO

ginsenoside Rg1 results in increased expression of GCLM protein
ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLM protein]

NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003

G

gap junction protein, alpha 1

multiple interactions

ISO

ginsenoside Rg1 inhibits the reaction [Dibutyl Phthalate results in decreased expression of GJA1 mRNA]; ginsenoside Rg1 inhibits the reaction [Dibutyl Phthalate results in decreased expression of GJA1 protein]

NCBI chr20:36,302,490...36,315,010
Ensembl chr20:36,302,352...36,319,689

G

glutamate dehydrogenase 1

multiple interactions

EXP

ginsenoside Rg1 inhibits the reaction [Oxygen deficiency results in increased expression of GLUD1 protein]

NCBI chr16:9,646,569...9,680,215
Ensembl chr16:9,646,509...9,680,210

G

glutamic--pyruvic transaminase

multiple interactions

ISO

ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein]

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

glycogen synthase kinase 3 beta

multiple interactions

EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in decreased phosphorylation of GSK3B protein]]; ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in decreased phosphorylation of GSK3B protein]

NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249

G

H2A.X variant histone

multiple interactions

ISO

ginsenoside Rg1 promotes the reaction [Doxorubicin results in increased expression of H2AX mRNA]

NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:53,568,281...53,573,079

G

heme oxygenase 1

multiple interactions
increases expression

ISO

[astragaloside A co-treated with ginsenoside Rg1 co-treated with ginsenoside Rb1 co-treated with notoginsenoside R1] results in increased expression of HMOX1 mRNA; [astragaloside A co-treated with ginsenoside Rg1 co-treated with ginsenoside Rb1 co-treated with notoginsenoside R1] results in increased expression of HMOX1 protein; ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in decreased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in decreased expression of HMOX1 mRNA]]; Tretinoin inhibits the reaction [ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in decreased expression of HMOX1 mRNA]]
ginsenoside Rg1 results in increased expression of HMOX1 mRNA; ginsenoside Rg1 results in increased expression of HMOX1 protein

PMID:25422538 PMID:29964319

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

heat shock protein family A (Hsp70) member 5

multiple interactions

ISO

ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in increased expression of HSPA5 protein]

NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790

G

interferon gamma

multiple interactions

EXP

ginsenoside Rg1 inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IFNG protein]

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

interleukin 1 beta

multiple interactions

ISO
EXP

1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B]]; ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B protein]; ginsenoside Rg1 inhibits the reaction [Chlorpyrifos results in increased expression of IL1B protein]; ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B]
ginsenoside Rg1 inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL1B protein]

PMID:22214447 PMID:29964319 PMID:32198087 PMID:36811218

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 6

multiple interactions

EXP
ISO

ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; ginsenoside Rg1 inhibits the reaction [Oxygen deficiency results in increased expression of IL6 protein]
ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 protein]; ginsenoside Rg1 inhibits the reaction [Chlorpyrifos results in increased expression of IL6 protein]; ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]

PMID:17655881 PMID:29964319 PMID:30918470 PMID:36811218 PMID:37923178

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

inhibin subunit alpha

multiple interactions

ISO

ginsenoside Rg1 inhibits the reaction [Dibutyl Phthalate results in decreased expression of INHA protein]

NCBI chr 9:84,443,109...84,446,010
Ensembl chr 9:84,443,109...84,446,009

G

potassium voltage-gated channel subfamily H member 2

affects activity

ISO

ginsenoside Rg1 affects the activity of KCNH2 protein

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421

G

Kelch-like ECH-associated protein 1

multiple interactions

ISO

ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in increased expression of KEAP1 protein]

NCBI chr 8:28,044,555...28,054,042
Ensembl chr 8:28,044,555...28,054,042

G

luteinizing hormone subunit beta

multiple interactions

ISO

ginsenoside Rg1 inhibits the reaction [Dibutyl Phthalate results in decreased expression of LHB protein]

NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:105,037,457...105,038,445

G

lipoprotein lipase

increases secretion

ISO

ginsenoside Rg1 results in increased secretion of LPL protein

NCBI chr16:25,596,205...25,621,928
Ensembl chr16:25,596,211...25,622,107

G

microtubule-associated protein 2

increases expression

ISO

ginsenoside Rg1 results in increased expression of MAP2 mRNA

NCBI chr 9:75,173,038...75,431,606
Ensembl chr 9:75,288,262...75,428,459

G

mitogen activated protein kinase 1

multiple interactions
affects phosphorylation

ISO

PLCG1 affects the reaction [ginsenoside Rg1 affects the phosphorylation of MAPK1 protein]

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

affects phosphorylation
multiple interactions

ISO

ginsenoside Rg1 affects the phosphorylation of MAPK3 protein
PLCG1 affects the reaction [ginsenoside Rg1 affects the phosphorylation of MAPK3 protein]

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

mitogen-activated protein kinase 8

multiple interactions

ISO

ginsenoside Rg1 inhibits the reaction [cobaltous chloride results in increased phosphorylation of MAPK8 protein]

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427

G

mitogen-activated protein kinase 9

multiple interactions

ISO

ginsenoside Rg1 inhibits the reaction [cobaltous chloride results in increased phosphorylation of MAPK9 protein]

NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228

G

MET proto-oncogene, receptor tyrosine kinase

multiple interactions
increases expression

ISO

Mifepristone inhibits the reaction [ginsenoside Rg1 results in increased expression of MET protein]; MIR23A mRNA inhibits the reaction [ginsenoside Rg1 results in increased expression of MET protein]

NCBI chr 4:46,756,823...46,864,041
Ensembl chr 4:46,756,506...46,870,821

G

mitofusin 2

multiple interactions

EXP

ginsenoside Rg1 inhibits the reaction [Oxygen deficiency results in decreased expression of MFN2 mRNA]; ginsenoside Rg1 inhibits the reaction [Oxygen deficiency results in decreased expression of MFN2 protein]

NCBI chr 5:163,587,463...163,617,363
Ensembl chr 5:163,587,463...163,618,495

G

microRNA 23a

decreases expression
multiple interactions

ISO

ginsenoside Rg1 results in decreased expression of MIR23A mRNA
Mifepristone inhibits the reaction [ginsenoside Rg1 results in decreased expression of MIR23A mRNA]; MIR23A mRNA inhibits the reaction [ginsenoside Rg1 results in increased expression of MET protein]

NCBI chr19:40,859,769...40,859,843

G

matrix metallopeptidase 2

increases expression

EXP

ginsenoside Rg1 results in increased expression of MMP2 protein

NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856

G

matrix metallopeptidase 9

increases expression

EXP

ginsenoside Rg1 results in increased expression of MMP9 protein

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442

G

mechanistic target of rapamycin kinase

multiple interactions

ISO

ginsenoside Rg1 inhibits the reaction [cobaltous chloride results in decreased activity of [MTOR protein binds to RAPTOR protein]]; ginsenoside Rg1 results in increased activity of [MTOR protein binds to RAPTOR protein]
ginsenoside Rg1 inhibits the reaction [Dibutyl Phthalate results in decreased expression of MTOR protein]

PMID:24386346 PMID:33331133

NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435

G

NFE2 like bZIP transcription factor 2

multiple interactions
affects localization
increases expression

ISO

[ginsenoside Rg1 co-treated with ginsenoside 20S-protopanaxatriol] results in increased expression of NFE2L2 protein
ginsenoside Rg1 affects the localization of NFE2L2 protein
[astragaloside A co-treated with ginsenoside Rg1 co-treated with ginsenoside Rb1 co-treated with notoginsenoside R1] affects the localization of NFE2L2 protein; ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in decreased expression of NFE2L2 protein]; NFE2L2 protein affects the reaction [ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLC mRNA]]; NFE2L2 protein affects the reaction [ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in decreased expression of HMOX1 mRNA]]; NFE2L2 protein affects the reaction [ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in decreased expression of NQO1 mRNA]]; Tretinoin inhibits the reaction [ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in decreased expression of NFE2L2 protein]]
ginsenoside Rg1 results in increased expression of NFE2L2 mRNA

PMID:22780686 PMID:25422538 PMID:29964319

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

NFKB inhibitor alpha

affects phosphorylation
multiple interactions

ISO

ginsenoside Rg1 affects the phosphorylation of NFKBIA protein
PLCG1 affects the reaction [ginsenoside Rg1 affects the phosphorylation of NFKBIA protein]

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072

G

nitric oxide synthase 2

multiple interactions

ISO

1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2]]; ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]; ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2]

PMID:22214447 PMID:29964319

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

NAD(P)H quinone dehydrogenase 1

multiple interactions

ISO

ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in decreased expression of NQO1 mRNA]; ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in decreased expression of NQO1 protein]; NFE2L2 protein affects the reaction [ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in decreased expression of NQO1 mRNA]]; Tretinoin inhibits the reaction [ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in decreased expression of NQO1 mRNA]]

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260

G

nuclear receptor subfamily 1, group H, member 4

multiple interactions

EXP

ginsenoside Rg1 inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of NR1H4 mRNA]; ginsenoside Rg1 inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of NR1H4 protein]

NCBI chr 7:25,733,471...25,829,440
Ensembl chr 7:25,733,471...25,829,389

G

progesterone receptor

increases expression

ISO

ginsenoside Rg1 results in increased expression of PGR protein

NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:14,354,398...14,413,271

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

multiple interactions

ISO

ginsenoside Rg1 inhibits the reaction [Dibutyl Phthalate results in decreased expression of PIK3CA mRNA]

NCBI chr 2:117,103,643...117,177,411
Ensembl chr 2:117,143,468...117,177,411

G

phospholipase C, gamma 1

multiple interactions

ISO

PLCG1 affects the reaction [ginsenoside Rg1 affects the phosphorylation of MAPK1 protein]; PLCG1 affects the reaction [ginsenoside Rg1 affects the phosphorylation of MAPK3 protein]; PLCG1 affects the reaction [ginsenoside Rg1 affects the phosphorylation of NFKBIA protein]

NCBI chr 3:169,805,299...169,836,040
Ensembl chr 3:169,804,846...169,836,050

G

protein kinase AMP-activated catalytic subunit alpha 1

multiple interactions

ISO

ginsenoside Rg1 inhibits the reaction [cobaltous chloride results in increased phosphorylation of PRKAA1 protein]

NCBI chr 2:55,967,766...56,003,450
Ensembl chr 2:55,967,351...56,003,450

G

phosphatase and tensin homolog

multiple interactions

ISO

ginsenoside Rg1 inhibits the reaction [Dibutyl Phthalate results in increased expression of PTEN protein]

NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:240,043,707...240,110,330

G

prostaglandin-endoperoxide synthase 2

multiple interactions

ISO

1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2]]; ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein]; ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2]

PMID:22214447 PMID:29964319

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

RAD51 recombinase

multiple interactions

ISO

ginsenoside Rg1 promotes the reaction [Doxorubicin results in increased expression of RAD51 mRNA]

NCBI chr 3:126,554,210...126,578,888
Ensembl chr 3:126,554,190...126,579,469

G

ribosomal protein S6

increases phosphorylation

ISO

ginsenoside Rg1 results in increased phosphorylation of RPS6 protein

NCBI chr 5:106,417,680...106,420,540
Ensembl chr 5:106,417,680...106,420,566

G

regulatory associated protein of MTOR, complex 1

multiple interactions

ISO

ginsenoside Rg1 inhibits the reaction [cobaltous chloride results in decreased activity of [MTOR protein binds to RAPTOR protein]]; ginsenoside Rg1 results in increased activity of [MTOR protein binds to RAPTOR protein]

NCBI chr10:105,376,943...105,675,416
Ensembl chr10:105,376,943...105,675,413

G

sirtuin 1

multiple interactions

ISO

ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in increased expression of SIRT1 protein]

NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000

G

solute carrier family 10 member 1

multiple interactions

EXP

ginsenoside Rg1 inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLC10A1 mRNA]; ginsenoside Rg1 inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLC10A1 protein]

NCBI chr 6:106,344,319...106,357,944
Ensembl chr 6:106,344,319...106,357,944

G

solute carrier organic anion transporter family member 1B2

multiple interactions

EXP
ISO

SLCO1B2 protein binds to and results in increased transport of ginsenoside Rg1
SLCO1B3 protein binds to and results in increased transport of ginsenoside Rg1

NCBI chr 4:176,282,577...176,355,557
Ensembl chr 4:176,282,584...176,351,083

G

superoxide dismutase 1

multiple interactions

EXP

ginsenoside Rg1 inhibits the reaction [Oxygen deficiency results in decreased expression of SOD1 protein]

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399

G

sulfotransferase family 2A member 1

multiple interactions

EXP

ginsenoside Rg1 inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SULT2A1 mRNA]; ginsenoside Rg1 inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SULT2A1 protein]

NCBI chr 1:84,582,011...84,639,001

G

trefoil factor 1

increases expression

ISO

ginsenoside Rg1 results in increased expression of TFF1 mRNA

NCBI chr20:9,237,095...9,240,956
Ensembl chr20:9,237,095...9,240,956

G

tumor necrosis factor

multiple interactions

ISO
EXP

1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in increased expression of TNF]]; ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; ginsenoside Rg1 inhibits the reaction [Chlorpyrifos results in increased expression of TNF protein]; ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in increased expression of TNF]; ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
ginsenoside Rg1 inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of TNF protein]; ginsenoside Rg1 inhibits the reaction [Oxygen deficiency results in increased expression of TNF protein]

PMID:22214447 PMID:29964319 PMID:30918470 PMID:32198087 PMID:36811218 More...

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

tumor protein p53

multiple interactions

ISO

ginsenoside Rg1 promotes the reaction [Doxorubicin results in increased expression of TP53 mRNA]

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

UDP glucuronosyltransferase family 1 member A1

multiple interactions

EXP

ginsenoside Rg1 inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of UGT1A1 mRNA]; ginsenoside Rg1 inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of UGT1A1 protein]

NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

X-ray repair cross complementing 1

multiple interactions

ISO

ginsenoside Rg1 promotes the reaction [Doxorubicin results in increased expression of XRCC1 mRNA]

NCBI chr 1:89,268,721...89,296,619
Ensembl chr 1:89,268,644...89,296,613

ginsenoside Rg2

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 2

increases expression

EXP

ginsenoside Rg2 results in increased expression of ABCC2 mRNA

NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471

G

AKT serine/threonine kinase 1

multiple interactions

EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rg2 inhibits the reaction [APP protein modified form results in decreased phosphorylation of AKT1 protein]]; ginsenoside Rg2 inhibits the reaction [APP protein modified form results in decreased phosphorylation of AKT1 protein]

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

amyloid beta precursor protein

multiple interactions

EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rg2 inhibits the reaction [APP protein modified form results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rg2 inhibits the reaction [APP protein modified form results in increased activity of CASP3 protein]]; ginsenoside Rg2 inhibits the reaction [APP protein modified form results in decreased expression of BCL2 protein]; ginsenoside Rg2 inhibits the reaction [APP protein modified form results in decreased phosphorylation of AKT1 protein]; ginsenoside Rg2 inhibits the reaction [APP protein modified form results in increased activity of and results in increased cleavage of CASP3 protein]; ginsenoside Rg2 inhibits the reaction [APP protein modified form results in increased expression of BAX protein]

NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971

G

BCL2 associated X, apoptosis regulator

multiple interactions

EXP

ginsenoside Rg2 inhibits the reaction [APP protein modified form results in increased expression of BAX protein]

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

multiple interactions

EXP

ginsenoside Rg2 inhibits the reaction [APP protein modified form results in decreased expression of BCL2 protein]

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

beclin 2

multiple interactions

ISO

ginsenoside Rg2 inhibits the reaction [BECN2 protein binds to GPRASP1 protein]

NCBI chr13:90,375,186...90,424,533
Ensembl chr13:90,375,186...90,378,488

G

caspase 3

multiple interactions

EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rg2 inhibits the reaction [APP protein modified form results in increased activity of CASP3 protein]]; ginsenoside Rg2 inhibits the reaction [APP protein modified form results in increased activity of and results in increased cleavage of CASP3 protein]

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

CREB regulated transcription coactivator 2

multiple interactions

ISO

[ginsenoside Rg2 results in increased activity of NR0B2 protein] which results in decreased activity of CRTC2 protein

NCBI chr 2:178,007,233...178,017,397
Ensembl chr 2:178,007,240...178,017,389

G

glucose 6 phosphatase catalytic subunit 3

decreases expression
multiple interactions

ISO

ginsenoside Rg2 results in decreased expression of G6PC3 mRNA
dorsomorphin inhibits the reaction [ginsenoside Rg2 results in decreased expression of G6PC3 mRNA]

NCBI chr10:87,647,149...87,651,385
Ensembl chr10:87,647,062...87,653,453

G

G protein-coupled receptor associated sorting protein 1

multiple interactions

ISO

ginsenoside Rg2 inhibits the reaction [BECN2 protein binds to GPRASP1 protein]

NCBI chr X:103,556,493...103,564,275
Ensembl chr X:103,501,377...103,565,649

G

glycogen synthase kinase 3 beta

increases phosphorylation
multiple interactions

ISO

ginsenoside Rg2 results in increased phosphorylation of GSK3B protein
[[ginsenoside Rg2 results in increased phosphorylation of GSK3B protein] co-treated with [ginsenoside Rg2 results in increased expression of NR0B2 mRNA]] results in decreased chemical synthesis of Glucose; dorsomorphin inhibits the reaction [ginsenoside Rg2 results in increased phosphorylation of GSK3B protein]

NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249

G

microtubule-associated protein 1 light chain 3 beta

multiple interactions
increases expression

ISO

bafilomycin A1 promotes the reaction [ginsenoside Rg2 results in increased expression of MAP1LC3B protein modified form]

NCBI chr19:66,571,631...66,582,270
Ensembl chr19:66,574,407...66,584,358
Ensembl chr16:66,574,407...66,584,358

G

nuclear receptor subfamily 0, group B, member 2

multiple interactions
increases expression
increases activity

ISO

[[ginsenoside Rg2 results in increased phosphorylation of GSK3B protein] co-treated with [ginsenoside Rg2 results in increased expression of NR0B2 mRNA]] results in decreased chemical synthesis of Glucose; [ginsenoside Rg2 results in increased activity of NR0B2 protein] which results in decreased activity of CRTC2 protein

NCBI chr 5:151,063,160...151,066,475
Ensembl chr 5:151,063,160...151,066,475

G

phosphoenolpyruvate carboxykinase 1

multiple interactions
decreases expression

ISO

dorsomorphin inhibits the reaction [ginsenoside Rg2 results in decreased expression of PCK1 mRNA]

NCBI chr 3:182,348,572...182,354,521
Ensembl chr 3:182,348,572...182,354,561

G

PPARG coactivator 1 alpha

multiple interactions
decreases expression

ISO

dorsomorphin inhibits the reaction [ginsenoside Rg2 results in decreased expression of PPARGC1A mRNA]

NCBI chr14:63,073,505...63,729,215
Ensembl chr14:63,273,189...63,729,213

G

sequestosome 1

multiple interactions
decreases expression

ISO

bafilomycin A1 promotes the reaction [ginsenoside Rg2 results in decreased expression of SQSTM1 protein]

NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750

G

serine/threonine kinase 11

increases phosphorylation
multiple interactions

ISO

ginsenoside Rg2 results in increased phosphorylation of STK11 protein
dorsomorphin inhibits the reaction [ginsenoside Rg2 results in increased phosphorylation of STK11 protein]

NCBI chr 7:10,225,204...10,241,965
Ensembl chr 7:10,225,204...10,241,965

gypenoside LXXV

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

increases phosphorylation
multiple interactions

ISO

gypenoside LXXV results in increased phosphorylation of AKT1 protein
2-chloro-5-nitrobenzanilide inhibits the reaction [gypenoside LXXV results in increased phosphorylation of AKT1 protein]

PMID:35192202 PMID:36325883

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

C-C motif chemokine ligand 2

multiple interactions

ISO

gypenoside LXXV inhibits the reaction [LEPR gene mutant form results in increased expression of CCL2 protein]

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

cellular communication network factor 2

multiple interactions
increases expression

ISO

gypenoside LXXV results in increased expression of and results in increased secretion of CTGF protein
gypenoside LXXV results in increased expression of CTGF mRNA

NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:22,621,501...22,624,976

G

interleukin 1 beta

multiple interactions

ISO

gypenoside LXXV inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; gypenoside LXXV inhibits the reaction [LEPR gene mutant form results in increased expression of IL1B protein]

PMID:33050067 PMID:35192202

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 6

multiple interactions

ISO

gypenoside LXXV inhibits the reaction [LEPR gene mutant form results in increased expression of IL6 protein]

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

insulin receptor substrate 1

decreases phosphorylation
multiple interactions

ISO

gypenoside LXXV results in decreased phosphorylation of IRS1 protein
2-chloro-5-nitrobenzanilide inhibits the reaction [gypenoside LXXV results in decreased expression of and results in decreased phosphorylation of IRS1 protein]; gypenoside LXXV results in decreased expression of and results in decreased phosphorylation of IRS1 protein

PMID:35192202 PMID:36325883

NCBI chr 9:91,001,137...91,053,959
Ensembl chr 9:90,993,519...91,054,538

G

leptin receptor

multiple interactions

ISO

gypenoside LXXV inhibits the reaction [LEPR gene mutant form results in increased expression of CCL2 protein]; gypenoside LXXV inhibits the reaction [LEPR gene mutant form results in increased expression of IL1B protein]; gypenoside LXXV inhibits the reaction [LEPR gene mutant form results in increased expression of IL6 protein]; gypenoside LXXV inhibits the reaction [LEPR gene mutant form results in increased expression of TNF protein]

NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:121,474,099...121,591,215

G

nuclear receptor subfamily 3, group C, member 2

multiple interactions

ISO

gypenoside LXXV binds to and affects the localization of NR3C2 protein

NCBI chr19:47,619,853...47,964,089
Ensembl chr19:47,619,853...47,964,078

G

peroxisome proliferator-activated receptor gamma

increases expression
multiple interactions

ISO
EXP

gypenoside LXXV results in increased expression of PPARG protein
2-chloro-5-nitrobenzanilide inhibits the reaction [gypenoside LXXV results in increased expression of PPARG protein]
2-chloro-5-nitrobenzanilide inhibits the reaction [gypenoside LXXV binds to and results in increased activity of PPARG protein]; gypenoside LXXV binds to and results in increased activity of PPARG protein

PMID:35192202 PMID:36325883

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

ISO

gypenoside LXXV results in decreased expression of and results in decreased phosphorylation of RELA protein

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

solute carrier family 2 member 4

affects localization
increases expression
multiple interactions

ISO

gypenoside LXXV affects the localization of SLC2A4 protein
gypenoside LXXV results in increased expression of SLC2A4 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [gypenoside LXXV affects the localization of SLC2A4 protein]; 2-chloro-5-nitrobenzanilide inhibits the reaction [gypenoside LXXV affects the localization of SLC2A4 protein]; 2-chloro-5-nitrobenzanilide inhibits the reaction [gypenoside LXXV results in increased expression of SLC2A4 protein]

PMID:35192202 PMID:36325883

NCBI chr10:55,164,721...55,170,289
Ensembl chr10:55,164,721...55,170,270

G

transforming growth factor, beta 1

decreases expression

ISO

gypenoside LXXV results in decreased expression of TGFB1 protein

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899

G

tumor necrosis factor

multiple interactions

ISO

gypenoside LXXV inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of TNF protein]; gypenoside LXXV inhibits the reaction [LEPR gene mutant form results in increased expression of TNF protein]; gypenoside LXXV inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]

PMID:33050067 PMID:35192202

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

lanost-8-ene-3beta,30-diol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

3-hydroxy-3-methylglutaryl-CoA reductase

decreases activity

ISO

32-hydroxy-24,25-dihydrolanosterol results in decreased activity of HMGCR protein

NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 27, subfamily a, polypeptide 1

increases metabolic processing

ISO

CYP27A1 protein results in increased metabolism of Lanosterol

NCBI chr 9:83,712,402...83,743,222
Ensembl chr 9:83,713,293...83,743,215

G

cytochrome P450, family 51

multiple interactions

EXP
ISO

[Ketoconazole results in increased activity of CYP51 protein] which results in increased abundance of Lanosterol
CYP51A1 gene inhibits the reaction [Fluconazole results in decreased metabolism of and results in increased abundance of Lanosterol]; CYP51A1 gene inhibits the reaction [Itraconazole results in decreased metabolism of and results in increased abundance of Lanosterol]; CYP51A1 gene inhibits the reaction [Ketoconazole results in decreased metabolism of and results in increased abundance of Lanosterol]; CYP51A1 gene inhibits the reaction [Voriconazole results in decreased metabolism of and results in increased abundance of Lanosterol]

PMID:12617470 PMID:18694951

NCBI chr 4:30,991,693...31,010,147
Ensembl chr 4:30,991,613...31,010,450

G

epoxide hydrolase 1

multiple interactions

ISO

Lanosterol analog inhibits the reaction [EPHX1 protein results in increased metabolism of cholesterol alpha-oxide]

NCBI chr13:95,246,079...95,275,852
Ensembl chr13:95,246,080...95,321,981

G

epoxide hydrolase 2

multiple interactions

ISO

Lanosterol analog inhibits the reaction [EPHX2 protein results in increased metabolism of stilbene oxide analog]

NCBI chr15:44,465,447...44,503,157
Ensembl chr15:44,465,448...44,503,160

G

membrane associated ring-CH-type finger 6

increases stability

ISO

Lanosterol results in increased stability of MARCHF6 protein

NCBI chr 2:84,166,570...84,243,817
Ensembl chr 2:84,166,570...84,243,792

lucidenic acid N

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

heme oxygenase 1

increases expression

ISO

lucidenic acid N analog results in increased expression of HMOX1 protein

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

notoginsenoside R1

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

increases transport

EXP
ISO

ABCB11 protein results in increased transport of notoginsenoside R1

NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581

G

ATP binding cassette subfamily B member 1A

increases expression
multiple interactions

ISO

notoginsenoside R1 results in increased expression of ABCB1 mRNA
notoginsenoside R1 results in increased expression of ABCB1A mRNA
NR1I2 protein promotes the reaction [notoginsenoside R1 results in increased expression of ABCB1 mRNA]

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

G

ATP binding cassette subfamily C member 1

increases transport

ISO

ABCC1 protein results in increased transport of notoginsenoside R1

NCBI chr10:1,022,041...1,162,431
Ensembl chr10:1,038,947...1,162,404

G

ATP binding cassette subfamily C member 2

increases transport

EXP
ISO

ABCC2 protein results in increased transport of notoginsenoside R1

NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471

G

ATP binding cassette subfamily G member 2

increases transport

EXP
ISO

ABCG2 protein results in increased transport of notoginsenoside R1

NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:89,005,969...89,132,493

G

AKT serine/threonine kinase 1

increases phosphorylation
multiple interactions

ISO

notoginsenoside R1 results in increased phosphorylation of AKT1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [notoginsenoside R1 inhibits the reaction [triethylene glycol dimethacrylate results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [notoginsenoside R1 results in increased phosphorylation of AKT1 protein]; notoginsenoside R1 inhibits the reaction [triethylene glycol dimethacrylate results in decreased phosphorylation of AKT1 protein]

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

apolipoprotein E

multiple interactions

ISO

notoginsenoside R1 inhibits the reaction [APOE gene mutant form results in decreased abundance of Glutathione]; notoginsenoside R1 inhibits the reaction [APOE gene mutant form results in decreased expression of MIR20A mRNA]; notoginsenoside R1 inhibits the reaction [APOE gene mutant form results in increased abundance of Cholesterol]; notoginsenoside R1 inhibits the reaction [APOE gene mutant form results in increased abundance of Triglycerides]; notoginsenoside R1 inhibits the reaction [APOE gene mutant form results in increased expression of IFNG protein]; notoginsenoside R1 inhibits the reaction [APOE gene mutant form results in increased expression of IL2 protein]; notoginsenoside R1 inhibits the reaction [APOE gene mutant form results in increased expression of IL6 protein]; notoginsenoside R1 inhibits the reaction [APOE gene mutant form results in increased expression of MIR126A mRNA]; notoginsenoside R1 inhibits the reaction [APOE gene mutant form results in increased expression of MIR21A mRNA]; notoginsenoside R1 inhibits the reaction [APOE gene mutant form results in increased expression of TNF protein]

NCBI chr 1:88,481,889...88,485,816
Ensembl chr 1:88,481,385...88,485,855

G

amyloid beta precursor protein

multiple interactions

ISO
EXP

notoginsenoside R1 inhibits the reaction [[APP gene mutant form co-treated with PSEN1 gene mutant form] results in increased expression of APP protein modified form]
notoginsenoside R1 inhibits the reaction [APP protein modified form results in decreased expression of BCL2 protein]; notoginsenoside R1 inhibits the reaction [APP protein modified form results in increased cleavage of CASP3 protein]; notoginsenoside R1 inhibits the reaction [APP protein modified form results in increased expression of BAX protein]; notoginsenoside R1 inhibits the reaction [APP protein modified form results in increased phosphorylation of MAPK1 protein]; notoginsenoside R1 inhibits the reaction [APP protein modified form results in increased phosphorylation of MAPK3 protein]; notoginsenoside R1 inhibits the reaction [APP protein modified form results in increased phosphorylation of MAPK8 protein]; notoginsenoside R1 inhibits the reaction [APP protein modified form results in increased phosphorylation of MAPK9 protein]

PMID:24975829 PMID:25714973

NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971

G

ATP synthase F1 subunit delta

multiple interactions

EXP

15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid inhibits the reaction [notoginsenoside R1 inhibits the reaction [[Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in decreased expression of ATP5F1D protein]]; notoginsenoside R1 inhibits the reaction [[Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in decreased expression of ATP5F1D protein]

NCBI chr 7:10,211,260...10,218,989
Ensembl chr 7:10,211,262...10,216,583

G

BCL2 associated X, apoptosis regulator

multiple interactions

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [notoginsenoside R1 inhibits the reaction [triethylene glycol dimethacrylate results in increased expression of BAX protein]]; 3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [notoginsenoside R1 inhibits the reaction [triethylene glycol dimethacrylate results in increased expression of BAX protein]]; Cyclosporine inhibits the reaction [notoginsenoside R1 inhibits the reaction [triethylene glycol dimethacrylate results in increased expression of BAX protein]]; notoginsenoside R1 inhibits the reaction [Excitatory Amino Acid Agonists results in increased expression of BAX protein]; notoginsenoside R1 inhibits the reaction [triethylene glycol dimethacrylate results in increased expression of BAX protein]
notoginsenoside R1 inhibits the reaction [[Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in increased expression of BAX protein]; notoginsenoside R1 inhibits the reaction [Acrylamide results in increased expression of BAX protein]; notoginsenoside R1 inhibits the reaction [APP protein modified form results in increased expression of BAX protein]

PMID:19224577 PMID:24975829 PMID:25305180 PMID:31971015 PMID:33689844

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

multiple interactions
increases expression

ISO
EXP

notoginsenoside R1 inhibits the reaction [Excitatory Amino Acid Agonists results in decreased expression of BCL2 protein]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]
notoginsenoside R1 results in increased expression of BCL2
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid inhibits the reaction [notoginsenoside R1 inhibits the reaction [[Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in decreased expression of BCL2 protein]]; notoginsenoside R1 inhibits the reaction [[Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in decreased expression of BCL2 protein]; notoginsenoside R1 inhibits the reaction [Acrylamide results in decreased expression of BCL2 protein]; notoginsenoside R1 inhibits the reaction [APP protein modified form results in decreased expression of BCL2 protein]

PMID:19224577 PMID:20023602 PMID:23170834 PMID:24975829 PMID:25305180 More...

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

bone gamma-carboxyglutamate protein

multiple interactions
increases expression

ISO

fulvestrant inhibits the reaction [notoginsenoside R1 results in increased expression of BGLAP mRNA]

NCBI chr 2:176,136,341...176,137,318
Ensembl chr 2:176,136,341...176,137,318

G

BH3 interacting domain death agonist

multiple interactions

ISO

notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of BID protein modified form]

NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:155,785,377...155,808,275

G

caspase 3

multiple interactions

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [notoginsenoside R1 inhibits the reaction [triethylene glycol dimethacrylate results in increased cleavage of CASP3 protein]]; 3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [notoginsenoside R1 inhibits the reaction [triethylene glycol dimethacrylate results in increased cleavage of CASP3 protein]]; Cyclosporine inhibits the reaction [notoginsenoside R1 inhibits the reaction [triethylene glycol dimethacrylate results in increased cleavage of CASP3 protein]]; MCL1 protein promotes the reaction [notoginsenoside R1 inhibits the reaction [Bupivacaine results in increased cleavage of CASP3 protein]]; notoginsenoside R1 inhibits the reaction [Bupivacaine results in increased cleavage of CASP3 protein]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased activity of CASP3 protein]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of CASP3 protein modified form]; notoginsenoside R1 inhibits the reaction [triethylene glycol dimethacrylate results in increased cleavage of CASP3 protein]
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid inhibits the reaction [notoginsenoside R1 inhibits the reaction [[Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in increased cleavage of CASP3 protein]]; notoginsenoside R1 inhibits the reaction [[Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in increased activity of CASP3 protein]; notoginsenoside R1 inhibits the reaction [[Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in increased cleavage of CASP3 protein]; notoginsenoside R1 inhibits the reaction [Acrylamide results in increased expression of CASP3 protein]; notoginsenoside R1 inhibits the reaction [APP protein modified form results in increased cleavage of CASP3 protein]; notoginsenoside R1 inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased activity of CASP3 protein]

PMID:23170834 PMID:24437944 PMID:24720662 PMID:24975829 PMID:25305180 More...

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 8

multiple interactions

ISO

notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased activity of CASP8 protein]

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699

G

caspase 9

multiple interactions

ISO
EXP

MCL1 protein promotes the reaction [notoginsenoside R1 inhibits the reaction [Bupivacaine results in increased cleavage of CASP9 protein]]; notoginsenoside R1 inhibits the reaction [Bupivacaine results in increased cleavage of CASP9 protein]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased activity of CASP9 protein]
notoginsenoside R1 inhibits the reaction [Acrylamide results in increased expression of CASP9 protein]

PMID:23170834 PMID:31971015 PMID:38316350

Ensembl chr 5:159,391,188...159,409,648

G

catalase

multiple interactions

EXP

notoginsenoside R1 inhibits the reaction [Streptozocin results in decreased activity of CAT protein]

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

C-C motif chemokine ligand 2

multiple interactions

ISO

notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein]

PMID:23170834 PMID:25472953

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

choline O-acetyltransferase

increases expression

ISO

notoginsenoside R1 results in increased expression of CHAT

NCBI chr16:7,663,665...7,723,416
Ensembl chr16:7,663,665...7,723,416

G

component of inhibitor of nuclear factor kappa B kinase complex

multiple interactions

ISO

notoginsenoside R1 inhibits the reaction [Dextran Sulfate results in increased expression of CHUK protein modified form]

NCBI chr 1:252,908,748...252,944,273
Ensembl chr 1:252,908,749...252,944,273

G

cytochrome P450, family 1, subfamily a, polypeptide 2

decreases activity

EXP

notoginsenoside R1 results in decreased activity of CYP1A2 protein

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases expression

ISO

notoginsenoside R1 results in increased expression of CYP3A4 mRNA

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

estrogen receptor 1

multiple interactions
increases expression

ISO
EXP

notoginsenoside R1 results in increased phosphorylation of and results in increased activity of ESR1 protein
notoginsenoside R1 results in increased expression of ESR1; notoginsenoside R1 results in increased expression of ESR1 mRNA; notoginsenoside R1 results in increased expression of ESR1 protein
[1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole results in decreased activity of ESR1 protein] which results in decreased susceptibility to notoginsenoside R1; [notoginsenoside R1 co-treated with Lipopolysaccharides] results in increased expression of ESR1 protein; fulvestrant inhibits the reaction [[notoginsenoside R1 co-treated with Lipopolysaccharides] results in increased expression of ESR1 protein]

PMID:23170834 PMID:24720662 PMID:25738436 PMID:26362186

NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354

G

estrogen receptor 2

increases expression

EXP

notoginsenoside R1 results in increased expression of ESR2

NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:100,545,206...100,644,709

G

coagulation factor III, tissue factor

multiple interactions

ISO

notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of F3 mRNA]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of F3 protein]

NCBI chr 2:212,511,675...212,523,375
Ensembl chr 2:212,511,680...212,523,369

G

Fas cell surface death receptor

multiple interactions

ISO

notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of FAS mRNA]

NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104

G

fibronectin 1

multiple interactions

ISO

notoginsenoside R1 inhibits the reaction [Hydrogen Peroxide results in increased expression of and results in increased secretion of FN1 protein]; notoginsenoside R1 inhibits the reaction [Hydrogen Peroxide results in increased expression of FN1 mRNA]; notoginsenoside R1 inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of FN1 protein]; notoginsenoside R1 inhibits the reaction [TNF protein results in increased expression of FN1 mRNA]

NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:80,645,507...80,714,137

G

glutamate-cysteine ligase, catalytic subunit

multiple interactions
increases expression

EXP

Cycloheximide inhibits the reaction [notoginsenoside R1 results in increased expression of GCLC protein]; Dactinomycin inhibits the reaction [notoginsenoside R1 results in increased expression of GCLC protein]; fulvestrant inhibits the reaction [notoginsenoside R1 results in increased expression of GCLC protein]; NFE2L2 promotes the reaction [notoginsenoside R1 results in increased expression of GCLC protein]; notoginsenoside R1 promotes the reaction [Hydrogen Peroxide results in increased expression of GCLC protein]

NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893

G

glutamate ionotropic receptor NMDA type subunit 1

multiple interactions

ISO

[GRIN1 protein co-treated with GRIN2B protein] results in increased susceptibility to notoginsenoside R1

NCBI chr 3:28,501,836...28,528,754
Ensembl chr 3:28,501,836...28,528,754

G

glutamate ionotropic receptor NMDA type subunit 2B

multiple interactions

ISO

[GRIN1 protein co-treated with GRIN2B protein] results in increased susceptibility to notoginsenoside R1

NCBI chr 4:170,297,811...170,775,420
Ensembl chr 4:170,322,617...170,773,570

G

glycogen synthase kinase 3 beta

multiple interactions
increases expression

ISO
EXP

fulvestrant inhibits the reaction [notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in decreased expression of GSK3B protein modified form]]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in decreased expression of GSK3B protein modified form]; wortmannin inhibits the reaction [notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in decreased expression of GSK3B protein modified form]]
notoginsenoside R1 results in increased expression of GSK3B protein modified form

PMID:23170834 PMID:24720662

NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249

G

heme oxygenase 1

multiple interactions
increases expression

ISO
EXP

[astragaloside A co-treated with ginsenoside Rg1 co-treated with ginsenoside Rb1 co-treated with notoginsenoside R1] results in increased expression of HMOX1 mRNA; [astragaloside A co-treated with ginsenoside Rg1 co-treated with ginsenoside Rb1 co-treated with notoginsenoside R1] results in increased expression of HMOX1 protein
notoginsenoside R1 results in increased expression of HMOX1; notoginsenoside R1 results in increased expression of HMOX1 protein
Cycloheximide inhibits the reaction [notoginsenoside R1 results in increased expression of HMOX1 protein]; Dactinomycin inhibits the reaction [notoginsenoside R1 results in increased expression of HMOX1 protein]; fulvestrant inhibits the reaction [notoginsenoside R1 results in increased expression of HMOX1 protein]; NFE2L2 promotes the reaction [notoginsenoside R1 results in increased expression of HMOX1 protein]; notoginsenoside R1 promotes the reaction [Hydrogen Peroxide results in increased expression of HMOX1 protein]

PMID:24437944 PMID:24720662 PMID:25422538

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

intercellular adhesion molecule 1

multiple interactions

ISO

notoginsenoside R1 inhibits the reaction [Dextran Sulfate results in increased expression of ICAM1 mRNA]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]

PMID:23170834 PMID:25472953

NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617

G

insulin degrading enzyme

multiple interactions
increases expression

ISO

2-chloro-5-nitrobenzanilide inhibits the reaction [notoginsenoside R1 results in increased expression of IDE]

NCBI chr 1:244,415,495...244,516,925
Ensembl chr 1:244,416,343...244,514,526

G

interferon gamma

multiple interactions

ISO

notoginsenoside R1 inhibits the reaction [APOE gene mutant form results in increased expression of IFNG protein]; notoginsenoside R1 inhibits the reaction [Dextran Sulfate results in increased expression of IFNG mRNA]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG mRNA]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG protein]

PMID:23170834 PMID:24933211 PMID:25472953

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

inhibitor of nuclear factor kappa B kinase subunit beta

multiple interactions

ISO

notoginsenoside R1 inhibits the reaction [Dextran Sulfate results in increased expression of IKBKB protein modified form]

NCBI chr16:76,021,968...76,075,717
Ensembl chr16:76,022,008...76,081,911

G

interleukin 10

multiple interactions

ISO

notoginsenoside R1 promotes the reaction [Lipopolysaccharides results in increased expression of IL10 protein]

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580

G

interleukin 15

multiple interactions

ISO

notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of IL15 mRNA]

NCBI chr19:42,536,160...42,611,349
Ensembl chr19:42,545,346...42,611,348

G

interleukin 1 alpha

multiple interactions

ISO

notoginsenoside R1 inhibits the reaction [Dextran Sulfate results in increased expression of IL1A mRNA]

NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013

G

interleukin 1 beta

multiple interactions

ISO
EXP

notoginsenoside R1 inhibits the reaction [Dextran Sulfate results in increased expression of IL1B mRNA]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]
1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]]; Fulvestrant inhibits the reaction [notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]

PMID:23170834 PMID:25472953 PMID:25738436

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 2

multiple interactions

ISO

notoginsenoside R1 inhibits the reaction [APOE gene mutant form results in increased expression of IL2 protein]; notoginsenoside R1 inhibits the reaction [Dextran Sulfate results in increased expression of IL2 mRNA]

PMID:24933211 PMID:25472953

NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672

G

interleukin 6

multiple interactions

ISO
EXP

notoginsenoside R1 inhibits the reaction [APOE gene mutant form results in increased expression of IL6 protein]; notoginsenoside R1 inhibits the reaction [Dextran Sulfate results in increased expression of IL6 mRNA]; notoginsenoside R1 inhibits the reaction [Dextran Sulfate results in increased expression of IL6 protein]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; notoginsenoside R1 inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 protein]
1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; Fulvestrant inhibits the reaction [notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]

PMID:17655881 PMID:23170834 PMID:24933211 PMID:25472953 PMID:25738436

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

integrin-linked kinase

multiple interactions

EXP

notoginsenoside R1 inhibits the reaction [Streptozocin results in increased activity of ILK protein]

NCBI chr 1:169,500,716...169,506,972
Ensembl chr 1:169,498,681...169,506,964

G

integrin subunit alpha 3

multiple interactions

ISO

notoginsenoside R1 inhibits the reaction [Glucose results in decreased expression of ITGA3 mRNA]; notoginsenoside R1 inhibits the reaction [Glucose results in decreased expression of ITGA3 protein]; notoginsenoside R1 inhibits the reaction [Streptozocin results in decreased expression of ITGA3 mRNA]; notoginsenoside R1 inhibits the reaction [Streptozocin results in decreased expression of ITGA3 protein]

NCBI chr10:80,486,998...80,522,548
Ensembl chr10:80,486,999...80,518,901

G

integrin subunit alpha M

multiple interactions

EXP

notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of ITGAM protein]

NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:192,089,542...192,139,943

G

integrin subunit beta 1

multiple interactions

ISO

notoginsenoside R1 inhibits the reaction [Glucose results in decreased expression of ITGB1 mRNA]; notoginsenoside R1 inhibits the reaction [Glucose results in decreased expression of ITGB1 protein]; notoginsenoside R1 inhibits the reaction [Streptozocin results in decreased expression of ITGB1 mRNA]; notoginsenoside R1 inhibits the reaction [Streptozocin results in decreased expression of ITGB1 protein]

NCBI chr19:73,602,277...73,650,271
Ensembl chr19:73,602,126...73,650,269

G

integrin subunit beta 2

decreases expression
multiple interactions

ISO
EXP

notoginsenoside R1 results in decreased expression of ITGB2 protein
notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of ITGB2 protein]

PMID:17655881 PMID:18176958

NCBI chr20:11,061,009...11,097,242
Ensembl chr20:11,058,492...11,097,182

G

Janus kinase 1

increases phosphorylation

ISO

[notoginsenoside R1 results in increased phosphorylation of JAK1 protein] which results in increased phosphorylation of STAT3 protein; notoginsenoside R1 results in increased phosphorylation of JAK1 protein

NCBI chr 5:120,895,606...121,004,207
Ensembl chr 5:120,896,046...120,996,758

G

lactate dehydrogenase A

multiple interactions

ISO

notoginsenoside R1 inhibits the reaction [Bupivacaine results in increased secretion of LDHA protein]

NCBI chr 1:106,508,092...106,517,512
Ensembl chr 1:106,502,182...106,517,521

G

mitogen activated protein kinase 1

multiple interactions
increases phosphorylation

ISO
EXP

notoginsenoside R1 inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]; notoginsenoside R1 inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]
fulvestrant inhibits the reaction [notoginsenoside R1 results in increased phosphorylation of MAPK1 protein]; notoginsenoside R1 inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of MAPK1 mRNA]; notoginsenoside R1 inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased phosphorylation of MAPK1 protein]; notoginsenoside R1 inhibits the reaction [APP protein modified form results in increased phosphorylation of MAPK1 protein]

PMID:16458614 PMID:16632126 PMID:24437944 PMID:24975829 PMID:25004876

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

multiple interactions
increases phosphorylation

EXP
ISO

fulvestrant inhibits the reaction [notoginsenoside R1 results in increased phosphorylation of MAPK3 protein]; notoginsenoside R1 inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of MAPK3 mRNA]; notoginsenoside R1 inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased phosphorylation of MAPK3 protein]; notoginsenoside R1 inhibits the reaction [APP protein modified form results in increased phosphorylation of MAPK3 protein]
notoginsenoside R1 inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]; notoginsenoside R1 inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein]

PMID:16458614 PMID:16632126 PMID:24437944 PMID:24975829 PMID:25004876

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

mitogen-activated protein kinase 8

multiple interactions

EXP

notoginsenoside R1 inhibits the reaction [APP protein modified form results in increased phosphorylation of MAPK8 protein]

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427

G

mitogen-activated protein kinase 9

multiple interactions

EXP

notoginsenoside R1 inhibits the reaction [APP protein modified form results in increased phosphorylation of MAPK9 protein]

NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228

G

MCL1 apoptosis regulator, BCL2 family member

increases expression
increases activity
multiple interactions

ISO

notoginsenoside R1 results in increased expression of MCL1 mRNA; notoginsenoside R1 results in increased expression of MCL1 protein
notoginsenoside R1 results in increased activity of MCL1 promoter
[notoginsenoside R1 results in increased phosphorylation of STAT3 protein] which results in increased expression of MCL1 mRNA; cryptotanshinone inhibits the reaction [notoginsenoside R1 results in increased expression of MCL1 protein]; MCL1 protein promotes the reaction [notoginsenoside R1 inhibits the reaction [Bupivacaine results in increased cleavage of CASP3 protein]]; MCL1 protein promotes the reaction [notoginsenoside R1 inhibits the reaction [Bupivacaine results in increased cleavage of CASP9 protein]]

NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:185,908,168...185,938,782

G

microRNA 126a

multiple interactions

ISO

notoginsenoside R1 inhibits the reaction [APOE gene mutant form results in increased expression of MIR126A mRNA]

NCBI chr 3:29,813,150...29,813,267

G

microRNA 20a

multiple interactions

ISO

notoginsenoside R1 inhibits the reaction [APOE gene mutant form results in decreased expression of MIR20A mRNA]

NCBI chr15:98,588,303...98,588,387
Ensembl chr15:98,588,303...98,588,387

G

microRNA 21

multiple interactions

ISO

notoginsenoside R1 inhibits the reaction [APOE gene mutant form results in increased expression of MIR21A mRNA]

NCBI chr10:71,902,600...71,902,691

G

myeloperoxidase

multiple interactions
decreases expression

ISO
EXP

notoginsenoside R1 inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein]; notoginsenoside R1 inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]
notoginsenoside R1 results in decreased expression of MPO protein

PMID:20023602 PMID:25472953

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056

G

NFE2 like bZIP transcription factor 2

affects localization
multiple interactions

ISO
EXP

notoginsenoside R1 affects the localization of NFE2L2 protein
NFE2L2 promotes the reaction [notoginsenoside R1 results in increased expression of GCLC protein]; NFE2L2 promotes the reaction [notoginsenoside R1 results in increased expression of HMOX1 protein]; NFE2L2 promotes the reaction [notoginsenoside R1 results in increased expression of NQO1 protein]; notoginsenoside R1 promotes the reaction [Hydrogen Peroxide affects the localization of NFE2L2 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [notoginsenoside R1 inhibits the reaction [triethylene glycol dimethacrylate results in decreased expression of and affects the localization of NFE2L2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [notoginsenoside R1 results in increased expression of and affects the localization of NFE2L2 protein]; [astragaloside A co-treated with ginsenoside Rg1 co-treated with ginsenoside Rb1 co-treated with notoginsenoside R1] affects the localization of NFE2L2 protein; notoginsenoside R1 inhibits the reaction [triethylene glycol dimethacrylate results in decreased expression of and affects the localization of NFE2L2 protein]; notoginsenoside R1 results in increased expression of and affects the localization of NFE2L2 protein

PMID:24437944 PMID:24720662 PMID:25422538 PMID:33689844

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

NFKB inhibitor alpha

multiple interactions

ISO
EXP

notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein]; notoginsenoside R1 promotes the reaction [Lipopolysaccharides results in increased expression of NFKBIA mRNA]
fulvestrant inhibits the reaction [notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in decreased expression of NFKBIA protein]]; notoginsenoside R1 inhibits the reaction [Dextran Sulfate results in increased phosphorylation of NFKBIA protein]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in decreased expression of NFKBIA protein]; wortmannin inhibits the reaction [notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in decreased expression of NFKBIA protein]]

PMID:9102164 PMID:23170834 PMID:25472953 PMID:25738436

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072

G

nitric oxide synthase 2

multiple interactions

ISO
EXP

notoginsenoside R1 inhibits the reaction [Dextran Sulfate results in increased expression of NOS2 mRNA]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
[notoginsenoside R1 results in increased phosphorylation of and results in increased activity of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; notoginsenoside R1 results in increased phosphorylation of and results in increased activity of NOS2 protein

PMID:23170834 PMID:25472953 PMID:26045775

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

nitric oxide synthase 3

multiple interactions

ISO

notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in decreased expression of NOS3 protein]

NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664

G

NAD(P)H quinone dehydrogenase 1

multiple interactions
increases expression

EXP

Cycloheximide inhibits the reaction [notoginsenoside R1 results in increased expression of NQO1 protein]; Dactinomycin inhibits the reaction [notoginsenoside R1 results in increased expression of NQO1 protein]; fulvestrant inhibits the reaction [notoginsenoside R1 results in increased expression of NQO1 protein]; NFE2L2 promotes the reaction [notoginsenoside R1 results in increased expression of NQO1 protein]; notoginsenoside R1 promotes the reaction [Hydrogen Peroxide results in increased expression of NQO1 protein]

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions
increases activity
increases response to substance

ISO

notoginsenoside R1 binds to and results in increased activity of NR1I2 protein; NR1I2 protein promotes the reaction [notoginsenoside R1 results in increased expression of ABCB1 mRNA]; NR1I2 protein promotes the reaction [notoginsenoside R1 results in increased expression of UGT1A1 mRNA]
notoginsenoside R1 results in increased activity of NR1I2 protein
NR1I2 protein results in increased susceptibility to notoginsenoside R1

NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380

G

poly (ADP-ribose) polymerase 1

multiple interactions

ISO

notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of PARP1 protein modified form]

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

plasminogen activator, tissue type

increases expression
multiple interactions

ISO

notoginsenoside R1 results in increased expression of PLAT mRNA; notoginsenoside R1 results in increased expression of PLAT protein
notoginsenoside R1 results in increased expression of [PLAT protein binds to SERPINE1 protein]

PMID:8018658 PMID:9220151

NCBI chr16:75,943,061...76,022,037
Ensembl chr16:75,943,064...75,967,696

G

plasminogen activator, urokinase

increases expression

ISO

notoginsenoside R1 results in increased expression of PLAU mRNA; notoginsenoside R1 results in increased expression of PLAU protein

NCBI chr15:3,505,485...3,511,987
Ensembl chr15:3,505,487...3,512,030

G

peroxisome proliferator-activated receptor gamma

multiple interactions
increases expression

ISO

2-chloro-5-nitrobenzanilide inhibits the reaction [notoginsenoside R1 results in increased expression of PPARG]

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104

G

protein phosphatase 1, regulatory subunit 12A

multiple interactions

EXP

15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid inhibits the reaction [notoginsenoside R1 inhibits the reaction [[Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in increased phosphorylation of PPP1R12A protein]]; notoginsenoside R1 inhibits the reaction [[Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in increased phosphorylation of PPP1R12A protein]

NCBI chr 7:45,368,922...45,480,158
Ensembl chr 7:45,369,315...45,480,157

G

presenilin 1

multiple interactions

ISO

notoginsenoside R1 inhibits the reaction [[APP gene mutant form co-treated with PSEN1 gene mutant form] results in increased expression of APP protein modified form]

NCBI chr 6:109,054,160...109,106,191
Ensembl chr 6:109,060,352...109,106,189

G

prostaglandin-endoperoxide synthase 2

multiple interactions

ISO

notoginsenoside R1 inhibits the reaction [Dextran Sulfate results in increased expression of PTGS2 mRNA]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

ISO
EXP

notoginsenoside R1 inhibits the reaction [Dextran Sulfate results in increased expression of RELA protein modified form]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of RELA protein modified form]
1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and affects the localization of RELA protein]]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and affects the localization of RELA protein]

PMID:23170834 PMID:25472953 PMID:25738436

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

Rho-associated coiled-coil containing protein kinase 1

multiple interactions

EXP

notoginsenoside R1 inhibits the reaction [[Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in increased expression of ROCK1 protein]

NCBI chr18:1,387,360...1,509,218
Ensembl chr18:1,387,360...1,509,147

G

RUNX family transcription factor 2

increases expression
multiple interactions

ISO

notoginsenoside R1 results in increased expression of RUNX2 mRNA
fulvestrant inhibits the reaction [notoginsenoside R1 results in increased expression of RUNX2 mRNA]

NCBI chr 9:23,661,278...23,990,248
Ensembl chr 9:23,664,952...23,990,027

G

selectin E

decreases expression

ISO

notoginsenoside R1 results in decreased expression of SELE protein

NCBI chr13:78,935,997...78,945,905
Ensembl chr13:78,936,036...78,945,903

G

serpin family E member 1

multiple interactions
decreases activity

ISO

notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of SERPINE1 mRNA]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of SERPINE1 protein]; notoginsenoside R1 inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of SERPINE1 protein]; notoginsenoside R1 inhibits the reaction [TNF protein results in increased expression of SERPINE1 mRNA]; notoginsenoside R1 results in increased expression of [PLAT protein binds to SERPINE1 protein]
notoginsenoside R1 results in decreased activity of SERPINE1 protein

PMID:8018658 PMID:9102164 PMID:16458614

NCBI chr12:25,237,977...25,248,356
Ensembl chr12:25,237,952...25,248,357

G

solute carrier organic anion transporter family member 1B2

multiple interactions

EXP
ISO

SLCO1B2 protein binds to and results in increased transport of notoginsenoside R1
SLCO1B3 protein binds to and results in increased transport of notoginsenoside R1

NCBI chr 4:176,282,577...176,355,557
Ensembl chr 4:176,282,584...176,351,083

G

Sp7 transcription factor

multiple interactions
increases expression

ISO

fulvestrant inhibits the reaction [notoginsenoside R1 results in increased expression of SP7 mRNA]

NCBI chr 7:135,363,193...135,373,376
Ensembl chr 7:135,363,199...135,373,559

G

secreted protein acidic and cysteine rich

multiple interactions
increases expression

ISO

fulvestrant inhibits the reaction [notoginsenoside R1 results in increased expression of SPARC mRNA]

NCBI chr10:40,017,065...40,038,816
Ensembl chr10:40,017,075...40,039,268

G

sequestosome 1

affects localization
multiple interactions

ISO

notoginsenoside R1 affects the localization of SQSTM1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [notoginsenoside R1 affects the localization of SQSTM1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [notoginsenoside R1 inhibits the reaction [triethylene glycol dimethacrylate affects the localization of SQSTM1 protein]]; notoginsenoside R1 inhibits the reaction [triethylene glycol dimethacrylate affects the localization of SQSTM1 protein]

NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750

G

signal transducer and activator of transcription 3

multiple interactions
increases phosphorylation

ISO

[notoginsenoside R1 results in increased phosphorylation of STAT3 protein] which results in increased expression of MCL1 mRNA; notoginsenoside R1 results in increased phosphorylation of and results in increased localization of STAT3 protein
[notoginsenoside R1 results in increased phosphorylation of JAK1 protein] which results in increased phosphorylation of STAT3 protein

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359

G

tumor necrosis factor

multiple interactions
decreases expression

ISO
EXP

notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; notoginsenoside R1 inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of FN1 protein]; notoginsenoside R1 inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of SERPINE1 protein]; notoginsenoside R1 inhibits the reaction [TNF protein results in increased expression of FN1 mRNA]; notoginsenoside R1 inhibits the reaction [TNF protein results in increased expression of SERPINE1 mRNA]; notoginsenoside R1 inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]; notoginsenoside R1 inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein]
notoginsenoside R1 results in decreased expression of TNF
1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; fulvestrant inhibits the reaction [notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]
notoginsenoside R1 inhibits the reaction [APOE gene mutant form results in increased expression of TNF protein]; notoginsenoside R1 inhibits the reaction [Dextran Sulfate results in increased expression of TNF mRNA]; notoginsenoside R1 inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; notoginsenoside R1 inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]

PMID:9102164 PMID:16458614 PMID:16632126 PMID:20023602 PMID:23170834 More...

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

TNF receptor superfamily member 1A

multiple interactions

ISO

notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of TNFRSF1A mRNA]

NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:159,837,032...159,849,816

G

tumor protein p53

multiple interactions

ISO

notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of TRP53 mRNA]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of TRP53 protein]

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

thioredoxin 1

increases expression
multiple interactions

EXP

notoginsenoside R1 results in increased expression of TXN1 protein
notoginsenoside R1 inhibits the reaction [Acrylamide results in decreased expression of TXN1 protein]

NCBI chr 5:77,507,455...77,519,685
Ensembl chr 5:77,507,321...77,520,307

G

UDP glucuronosyltransferase family 1 member A1

increases expression
multiple interactions

ISO

notoginsenoside R1 results in increased expression of UGT1A1 mRNA
NR1I2 protein promotes the reaction [notoginsenoside R1 results in increased expression of UGT1A1 mRNA]

NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

vascular cell adhesion molecule 1

multiple interactions

ISO

notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 protein]

NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

interleukin 1 beta

multiple interactions

ISO

scalaradial inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]; scalaradial inhibits the reaction [IL1B protein results in increased expression of TNF protein]; scalaradial inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

myeloperoxidase

multiple interactions

ISO

scalaradial inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MPO protein]

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056

G

prostaglandin-endoperoxide synthase 2

multiple interactions

ISO

scalaradial inhibits the reaction [[Lipopolysaccharides results in increased expression of and results in increased activity of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; scalaradial inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]; scalaradial inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased activity of PTGS2 protein]

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

tumor necrosis factor

multiple interactions

ISO

scalaradial inhibits the reaction [IL1B protein results in increased expression of TNF protein]; scalaradial inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	20874
chemical entity	20872
group	20774
polyatomic entity	20745
molecule	20540
cyclic compound	20415
organic cyclic compound	20390
organic polycyclic compound	17588
organic tetracyclic compound	328
(-)-16-carbomethoxycleaviminium	0
Lentzeadiene	0
Sesterviolene A	0
Sesterviridene C	0
carbotetracyclic compound +	29
sesterviolene C	0
sesterviolene D	0
spiroluchuene A	0
tetracyclic triterpenoid +	311
Path 2
Term	Annotations
CHEBI ontology	20874
subatomic particle	20883
composite particle	20883
hadron	20872
baryon	20883
nucleon	20872
atomic nucleus	20883
atom	20872
main group element atom	20796
p-block element atom	20796
p-block molecular entity	20796
carbon group molecular entity	20724
organic molecular entity	20706
organic molecule	20499
organic cyclic compound	20390
organic polycyclic compound	17588
organic tetracyclic compound	328
(-)-16-carbomethoxycleaviminium	0
Lentzeadiene	0
Sesterviolene A	0
Sesterviridene C	0
carbotetracyclic compound +	29
sesterviolene C	0
sesterviolene D	0
spiroluchuene A	0
tetracyclic triterpenoid +	311

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