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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:N,N-dimethylglycine
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Accession:CHEBI:17724 term browser browse the term
Definition:An N-methylglycine that is glycine carrying two N-methyl substituents.
Synonyms:related_synonym: (dimethylamino)acetic acid;   2-(Dimethylamino)acetic acid;   Dimethylglycine;   Formula=C4H9NO2;   InChI=1S/C4H9NO2/c1-5(2)3-4(6)7/h3H2,1-2H3,(H,6,7);   InChIKey=FFDGPVCHZBVARC-UHFFFAOYSA-N;   N,N-Dimethylaminoacetic acid;   N-Methylsarcosine;   SMILES=CN(C)CC(O)=O
 alt_id: CHEBI:12426;   CHEBI:14173;   CHEBI:21455;   CHEBI:41993;   CHEBI:7077
 xref: CAS:1118-68-9;   DrugBank:DB02083;   Gmelin:82215;   HMDB:HMDB0000092;   KEGG:C01026
 xref_mesh: MESH:C025138
 xref: MetaCyc:DIMETHYL-GLYCINE;   PDBeChem:DMG;   PMID:17190852;   PMID:21228267;   PMID:22418088;   PMID:22510294;   Reaxys:1700261
 cyclic_relationship: is_tautomer_of CHEBI:58251


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N,N-dimethylglycine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase increases activity ISO dimethylglycine results in increased activity of CAT protein CTD PMID:27171376 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
decreases expression 		ISO dimethylglycine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of GPT protein]
dimethylglycine results in decreased expression of GPT protein 		CTD PMID:27171376 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
increases activity 		ISO dimethylglycine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased activity of GSR protein]
dimethylglycine results in increased activity of GSR protein 		CTD PMID:27171376 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO dimethylglycine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of SIRT1 mRNA] CTD PMID:27171376 NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000 		JBrowse link
G Sod2 superoxide dismutase 2 increases activity
multiple interactions 		ISO dimethylglycine results in increased activity of SOD2 protein
dimethylglycine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased activity of SOD2 protein] 		CTD PMID:27171376 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    chemical entity 20860
      atom 20860
        nonmetal atom 20766
          nitrogen atom 19595
            nitrogen molecular entity 19595
              organonitrogen compound 19403
                amino-acid derivative 12901
                  N-methyl-amino acid 16
                    N,N-dimethylglycine 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    main group molecular entity 20781
                      s-block molecular entity 20574
                        hydrogen molecular entity 20558
                          hydrides 19693
                            inorganic hydride 18602
                              pnictogen hydride 18589
                                nitrogen hydride 18502
                                  azane 18262
                                    ammonia 18261
                                      organic amino compound 18261
                                        amino acid 16340
                                          alpha-amino acid 14255
                                            serine family amino acid 6105
                                              glycine 3485
                                                glycine derivative 3473
                                                  N-alkylglycine 5
                                                    N-methylglycines 5
                                                      N,N-dimethylglycine 5
paths to the root