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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:N,N-dimethylglycine
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Accession:CHEBI:17724 term browser browse the term
Definition:An N-methylglycine that is glycine carrying two N-methyl substituents.
Synonyms:related_synonym: (dimethylamino)acetic acid;   2-(Dimethylamino)acetic acid;   Dimethylglycine;   Formula=C4H9NO2;   InChI=1S/C4H9NO2/c1-5(2)3-4(6)7/h3H2,1-2H3,(H,6,7);   InChIKey=FFDGPVCHZBVARC-UHFFFAOYSA-N;   N,N-Dimethylaminoacetic acid;   N-Methylsarcosine;   SMILES=CN(C)CC(O)=O
 alt_id: CHEBI:12426;   CHEBI:14173;   CHEBI:21455;   CHEBI:41993;   CHEBI:7077
 xref: CAS:1118-68-9;   DrugBank:DB02083;   Gmelin:82215;   HMDB:HMDB0000092;   KEGG:C01026
 xref_mesh: MESH:C025138
 xref: MetaCyc:DIMETHYL-GLYCINE;   PDBeChem:DMG;   PMID:17190852;   PMID:21228267;   PMID:22418088;   PMID:22510294;   Reaxys:1700261
 cyclic_relationship: is_tautomer_of CHEBI:58251


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N,N-dimethylglycine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase increases activity ISO dimethylglycine results in increased activity of CAT protein CTD PMID:27171376 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
decreases expression		 ISO dimethylglycine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of GPT protein]
dimethylglycine results in decreased expression of GPT protein		 CTD PMID:27171376 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
increases activity		 ISO dimethylglycine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased activity of GSR protein]
dimethylglycine results in increased activity of GSR protein		 CTD PMID:27171376 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO dimethylglycine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of SIRT1 mRNA] CTD PMID:27171376 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Sod2 superoxide dismutase 2 increases activity
multiple interactions		 ISO dimethylglycine results in increased activity of SOD2 protein
dimethylglycine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased activity of SOD2 protein]		 CTD PMID:27171376 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    chemical entity 19909
      atom 19909
        nonmetal atom 19832
          nitrogen atom 19009
            nitrogen molecular entity 18984
              organonitrogen compound 18859
                amino acid derivative 12606
                  N-methyl-amino acid 16
                    N,N-dimethylglycine 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    main group molecular entity 19849
                      s-block molecular entity 19681
                        hydrogen molecular entity 19662
                          hydrides 19167
                            inorganic hydride 18182
                              pnictogen hydride 18172
                                nitrogen hydride 18085
                                  azane 17866
                                    ammonia 17865
                                      organic amino compound 17888
                                        amino acid 16071
                                          alpha-amino acid 13929
                                            L-alpha-amino acid 12971
                                              serine family amino acid 5755
                                                glycine 3334
                                                  glycine derivative 3318
                                                    N-alkylglycine 5
                                                      N-methylglycines 5
                                                        N,N-dimethylglycine 5
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