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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:lactose
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Accession:CHEBI:17716 term browser browse the term
Definition:A glycosylglucose disaccharide, found most notably in milk, that consists of D-galactose and D-glucose fragments bonded through a beta-1->4 glycosidic linkage. The glucose fragment can be in either the alpha- or beta-pyranose form, whereas the galactose fragment can only have the beta-pyranose form.
Synonyms:related_synonym: (Gal)1 (Glc)1;   1-beta-D-Galactopyranosyl-4-D-glucopyranose;   4-(beta-D-galactosido)-D-glucose;   4-O-beta-D-galactopyranosyl-D-glucose;   D-lactose;   Formula=C12H22O11;   Galbeta1-4Glc;   InChI=1S/C12H22O11/c13-1-3-5(15)6(16)9(19)12(22-3)23-10-4(2-14)21-11(20)8(18)7(10)17/h3-20H,1-2H2/t3-,4-,5+,6+,7-,8-,9-,10-,11?,12+/m1/s1;   InChIKey=GUBGYTABKSRVRQ-QKKXKWKRSA-N;   Lac;   Laktobiose;   Laktose;   Milchzucker;   SMILES=OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O;   WURCS=2.0/2,2,1/[a2122h-1x_1-5][a2112h-1b_1-5]/1-2/a4-b1;   beta-D-Gal-(1->4)-D-Glc;   beta-D-Galp-(1->4)-D-Glcp;   beta-Gal1,4-Glc;   lactobiose;   milk sugar
 alt_id: CHEBI:10296;   CHEBI:10380;   CHEBI:14497;   CHEBI:22460;   CHEBI:22760;   CHEBI:25005;   CHEBI:27755;   CHEBI:613009
 xref: CAS:63-42-3;   GlyGen:G74621DY;   GlyTouCan:G74621DY;   Gmelin:882872;   KEGG:C00243;   KEGG:D00046;   KEGG:G10504;   KNApSAcK:C00001136
 xref_mesh: MESH:D007785
 xref: PMID:1292745;   PMID:17329833;   PMID:18300214;   PMID:19053747;   PMID:19846069;   PMID:19913595;   PMID:20094999;   PMID:20503067;   PMID:20699559;   PMID:20873837;   PMID:20961532;   PMID:21403918;   PMID:2432147;   PMID:2456994;   PMID:28690131;   PMID:28807538;   PMID:6194884;   PMID:7574700;   Reaxys:1292745


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lactose term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase decreases activity EXP Lactose results in decreased activity of CAT protein CTD PMID:2539851 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Lgals3 galectin 3 affects binding ISO Lactose binds to LGALS3 protein CTD PMID:17385862 NCBI chr15:23,099,795...23,111,731
Ensembl chr15:20,607,692...20,632,025 		JBrowse link
G Sod1 superoxide dismutase 1 decreases activity EXP Lactose results in decreased activity of SOD1 protein CTD PMID:2539851 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20856
    role 20816
      biological role 20814
        biochemical role 20261
          metabolite 20243
            eukaryotic metabolite 19957
              animal metabolite 19801
                mammalian metabolite 19800
                  human metabolite 19220
                    lactose 3
                      2'-fucosyllactose + 0
                      3-(hexadecylsulfonyl)-2-[(hexadecylsulfonyl)methyl]propyl beta-D-galactosyl-(1->4)-beta-D-glucoside 0
                      3-fucosyllactose + 0
                      D-Galp-(1->3)-beta-D-Galp-(1->4)-D-Glcp 0
                      D-Galp-(1->6)-beta-D-Galp-(1->4)-D-Glcp 0
                      alpha-L-Fucp-(1->4)-beta-D-Galp-(1->4)-D-Glcp 0
                      alpha-lactose + 0
                      beta-D-Galp-(1->3)-beta-D-Galp-(1->4)-D-Glcp 0
                      beta-D-Galp-(1->4)-[alpha-D-Glcp-(1->2)]-D-Glcp 0
                      beta-D-Galp-(1->6)-beta-D-Galp-(1->4)-D-Glcp 0
                      beta-D-Galp6S-(1->4)-D-Glcp 0
                      beta-D-GlcpNAc-(1->4)-beta-D-Galp-(1->4)-D-Glcp 0
                      beta-D-GlcpNAc-(1->6)-beta-D-Galp-(1->4)-D-Glcp 0
                      beta-L-Fucp-(1->4)-beta-D-Galp-(1->4)-D-Glcp 0
                      beta-lactose + 0
                      lactobionic acid + 0
                      lactose 6'-phosphate 0
                      lactose phosphate + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20856
    subatomic particle 20854
      composite particle 20854
        hadron 20854
          baryon 20854
            nucleon 20854
              atomic nucleus 20854
                atom 20854
                  main group element atom 20777
                    p-block element atom 20777
                      carbon group element atom 20710
                        carbon atom 20704
                          organic molecular entity 20704
                            heteroorganic entity 20215
                              organochalcogen compound 19902
                                organooxygen compound 19804
                                  carbohydrates and carbohydrate derivatives 15436
                                    carbohydrate 15436
                                      oligosaccharide 644
                                        disaccharide 545
                                          glycosylglucose 223
                                            lactose 3
                                              2'-fucosyllactose + 0
                                              3-(hexadecylsulfonyl)-2-[(hexadecylsulfonyl)methyl]propyl beta-D-galactosyl-(1->4)-beta-D-glucoside 0
                                              3-fucosyllactose + 0
                                              D-Galp-(1->3)-beta-D-Galp-(1->4)-D-Glcp 0
                                              D-Galp-(1->6)-beta-D-Galp-(1->4)-D-Glcp 0
                                              alpha-L-Fucp-(1->4)-beta-D-Galp-(1->4)-D-Glcp 0
                                              alpha-lactose + 0
                                              beta-D-Galp-(1->3)-beta-D-Galp-(1->4)-D-Glcp 0
                                              beta-D-Galp-(1->4)-[alpha-D-Glcp-(1->2)]-D-Glcp 0
                                              beta-D-Galp-(1->6)-beta-D-Galp-(1->4)-D-Glcp 0
                                              beta-D-Galp6S-(1->4)-D-Glcp 0
                                              beta-D-GlcpNAc-(1->4)-beta-D-Galp-(1->4)-D-Glcp 0
                                              beta-D-GlcpNAc-(1->6)-beta-D-Galp-(1->4)-D-Glcp 0
                                              beta-L-Fucp-(1->4)-beta-D-Galp-(1->4)-D-Glcp 0
                                              beta-lactose + 0
                                              lactobionic acid + 0
                                              lactose 6'-phosphate 0
                                              lactose phosphate + 0
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