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G |
Adora3 |
adenosine A3 receptor |
multiple interactions |
ISO |
[N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine binds to and results in increased activity of ADORA3 protein] which results in decreased susceptibility to Dizocilpine Maleate |
CTD |
PMID:12672554 |
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NCBI chr 2:193,352,759...193,392,946
Ensembl chr 2:193,388,713...193,392,357
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G |
Ahcyl2 |
adenosylhomocysteinase-like 2 |
increases expression |
EXP |
Dizocilpine Maleate results in increased expression of AHCYL2 protein |
CTD |
PMID:21297352 |
|
NCBI chr 4:58,381,290...58,531,061
Ensembl chr 4:58,381,218...58,531,060
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G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions |
EXP |
Dizocilpine Maleate inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 promoter]] |
CTD |
PMID:17973980 |
|
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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G |
Aifm1 |
apoptosis inducing factor, mitochondria associated 1 |
multiple interactions |
EXP |
Dizocilpine Maleate inhibits the reaction [Excitatory Amino Acid Agonists affects the localization of AIFM1 protein] |
CTD |
PMID:19201465 |
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NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256
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G |
Aldoc |
aldolase, fructose-bisphosphate C |
increases expression |
EXP |
Dizocilpine Maleate results in increased expression of ALDOC protein |
CTD |
PMID:21297352 |
|
NCBI chr10:63,217,477...63,221,066
Ensembl chr10:63,217,451...63,221,066
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G |
App |
amyloid beta precursor protein |
multiple interactions |
EXP |
Dizocilpine Maleate inhibits the reaction [Pentylenetetrazole results in increased expression of APP mRNA] |
CTD |
PMID:9720974 |
|
NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
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G |
Arc |
activity-regulated cytoskeleton-associated protein |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [phosphinothricin results in increased expression of ARC mRNA] |
CTD |
PMID:30557575 |
|
NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression multiple interactions |
ISO EXP |
Dizocilpine Maleate results in increased expression of BAX protein Dizocilpine Maleate inhibits the reaction [Dextromethorphan results in increased expression of BAX protein]; Dizocilpine Maleate inhibits the reaction [Excitatory Amino Acid Agonists results in increased expression of BAX protein] |
CTD |
PMID:19201465 PMID:19759125 PMID:25937004 PMID:28916251 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression multiple interactions |
EXP ISO |
Dizocilpine Maleate results in decreased expression of BCL2 protein Dizocilpine Maleate inhibits the reaction [decabromobiphenyl ether results in decreased expression of BCL2 protein] Dizocilpine Maleate inhibits the reaction [Cocaine results in increased phosphorylation of BCL2 protein] |
CTD |
PMID:10859492 PMID:19879923 PMID:29151189 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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|
G |
Bcl2l1 |
Bcl2-like 1 |
multiple interactions |
EXP |
Dizocilpine Maleate inhibits the reaction [Dextromethorphan results in decreased expression of BCL2L1 protein] |
CTD |
PMID:28916251 |
|
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 Ensembl chr 1:141,253,523...141,303,479
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|
G |
Bdnf |
brain-derived neurotrophic factor |
decreases expression multiple interactions affects expression |
EXP |
Dizocilpine Maleate results in decreased expression of BDNF mRNA Dizocilpine Maleate inhibits the reaction [Pilocarpine results in increased expression of and results in increased localization of BDNF mRNA]; Pentobarbital inhibits the reaction [Dizocilpine Maleate affects the expression of BDNF mRNA]; Scopolamine inhibits the reaction [Dizocilpine Maleate affects the expression of BDNF mRNA] |
CTD |
PMID:8247360 PMID:8405262 PMID:15282290 |
|
NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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|
G |
Camk2a |
calcium/calmodulin-dependent protein kinase II alpha |
multiple interactions |
EXP |
Dizocilpine Maleate inhibits the reaction [Excitatory Amino Acid Agents promotes the reaction [CAMK2A protein binds to DRD3 protein]] |
CTD |
PMID:19217379 |
|
NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994
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G |
Camk4 |
calcium/calmodulin-dependent protein kinase IV |
multiple interactions |
EXP |
Dizocilpine Maleate inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of CAMK4 protein] |
CTD |
PMID:17973980 |
|
NCBI chr18:24,582,988...24,811,918
Ensembl chr18:24,585,269...24,802,487
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G |
Casp3 |
caspase 3 |
multiple interactions increases activity increases expression |
EXP ISO |
Dizocilpine Maleate inhibits the reaction [[sodium bisulfite co-treated with sodium sulfite] results in increased cleavage of CASP3 protein]; Dizocilpine Maleate inhibits the reaction [D-Aspartic Acid results in increased activity of and results in increased cleavage of CASP3 protein]; Dizocilpine Maleate inhibits the reaction [Dextromethorphan results in increased cleavage of CASP3 protein]; Dizocilpine Maleate inhibits the reaction [Pilocarpine results in increased cleavage of CASP3 protein] Dizocilpine Maleate results in increased activity of CASP3 protein Dizocilpine Maleate results in increased expression of CASP3 protein modified form |
CTD |
PMID:19759125 PMID:21873648 PMID:22824136 PMID:25937004 PMID:28916251 PMID:30822420 More...
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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|
G |
Casp9 |
caspase 9 |
increases activity |
ISO |
Dizocilpine Maleate results in increased activity of CASP9 protein |
CTD |
PMID:19759125 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Cat |
catalase |
multiple interactions |
EXP |
[bastadin 12 co-treated with Ryanodine co-treated with Dizocilpine Maleate] inhibits the reaction [tetrabromobisphenol A results in decreased activity of CAT protein]; Dizocilpine Maleate inhibits the reaction [ammonium acetate results in decreased activity of CAT protein] |
CTD |
PMID:12885441 PMID:27718046 |
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Cck |
cholecystokinin |
multiple interactions decreases expression |
EXP |
Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of CCK mRNA]; Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of CCK protein] Dizocilpine Maleate results in decreased expression of CCK mRNA; Dizocilpine Maleate results in decreased expression of CCK protein |
CTD |
PMID:16567023 |
|
NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084
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G |
Chat |
choline O-acetyltransferase |
multiple interactions |
EXP |
Dizocilpine Maleate inhibits the reaction [Quinolinic Acid results in decreased activity of CHAT protein] |
CTD |
PMID:2976130 |
|
NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093
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G |
Cnr1 |
cannabinoid receptor 1 |
affects response to substance |
ISO |
CNR1 protein affects the susceptibility to Dizocilpine Maleate |
CTD |
PMID:17442049 |
|
NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099
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G |
Col1a1 |
collagen type I alpha 1 chain |
multiple interactions increases expression |
ISO |
Dizocilpine Maleate inhibits the reaction [Excitatory Amino Acid Agonists results in increased expression of COL1A1 mRNA] Dizocilpine Maleate results in increased expression of COL1A1 mRNA |
CTD |
PMID:28987794 |
|
NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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G |
Col3a1 |
collagen type III alpha 1 chain |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [Excitatory Amino Acid Agonists results in increased expression of COL3A1 mRNA] |
CTD |
PMID:28987794 |
|
NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
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G |
Creb1 |
cAMP responsive element binding protein 1 |
increases phosphorylation decreases phosphorylation multiple interactions |
EXP ISO |
Dizocilpine Maleate results in increased phosphorylation of CREB1 protein Dizocilpine Maleate results in decreased phosphorylation of CREB1 protein Dizocilpine Maleate inhibits the reaction [Formaldehyde results in increased expression of CREB1 mRNA] Dizocilpine Maleate inhibits the reaction [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased phosphorylation of CREB1 protein]; Dizocilpine Maleate inhibits the reaction [Dopamine results in increased phosphorylation of CREB1 protein]; Dizocilpine Maleate inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [CREB1 protein binds to CYP1A1 promoter]] Dizocilpine Maleate inhibits the reaction [Sodium Glutamate results in increased expression of CREB1 mRNA] |
CTD |
PMID:14622123 PMID:15877933 PMID:17434604 PMID:17973980 PMID:31981724 |
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NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
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G |
Ctnnb1 |
catenin beta 1 |
decreases expression multiple interactions |
ISO |
Dizocilpine Maleate results in decreased expression of CTNNB1 mRNA Famotidine inhibits the reaction [Dizocilpine Maleate results in decreased expression of CTNNB1 mRNA]; Olanzapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of CTNNB1 mRNA] |
CTD |
PMID:31563592 |
|
NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
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G |
Cxcl2 |
C-X-C motif chemokine ligand 2 |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [Excitatory Amino Acid Agonists results in decreased activity of CXCL2 protein] |
CTD |
PMID:15914698 |
|
NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions |
EXP |
Dizocilpine Maleate inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 promoter]]; Dizocilpine Maleate inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [CREB1 protein binds to CYP1A1 promoter]] |
CTD |
PMID:17973980 |
|
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp46a1 |
cytochrome P450, family 46, subfamily a, polypeptide 1 |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [Sodium Glutamate results in increased expression of CYP46A1 mRNA]; Dizocilpine Maleate inhibits the reaction [Sodium Glutamate results in increased expression of CYP46A1 protein] |
CTD |
PMID:31981724 |
|
NCBI chr 6:127,247,543...127,274,765
Ensembl chr 6:127,243,315...127,274,760
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G |
Dlg1 |
discs large MAGUK scaffold protein 1 |
increases expression |
EXP |
Dizocilpine Maleate results in increased expression of DLG1 mRNA |
CTD |
PMID:11169168 |
|
NCBI chr11:68,911,883...69,103,230
Ensembl chr11:68,911,883...69,102,689
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G |
Dlg4 |
discs large MAGUK scaffold protein 4 |
increases expression |
EXP |
Dizocilpine Maleate results in increased expression of DLG4 mRNA |
CTD |
PMID:11169168 |
|
NCBI chr10:54,740,700...54,769,097
Ensembl chr10:54,739,470...54,767,153
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G |
Dnm1l |
dynamin 1-like |
multiple interactions |
EXP |
Dizocilpine Maleate inhibits the reaction [Excitatory Amino Acid Agonists results in decreased expression of DNM1L protein] |
CTD |
PMID:25416777 |
|
NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482
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G |
Drd1 |
dopamine receptor D1 |
multiple interactions |
ISO |
[[2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine co-treated with Dizocilpine Maleate] co-treated with [1-hydroxy-3-amino-2-pyrrolidone results in increased activity of DRD1 protein]] results in increased susceptibility to Pilocarpine; Dizocilpine Maleate inhibits the reaction [Formaldehyde results in increased expression of DRD1 mRNA] |
CTD |
PMID:7906944 PMID:17434604 |
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NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002
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G |
Drd2 |
dopamine receptor D2 |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [Formaldehyde results in increased expression of DRD2 mRNA] |
CTD |
PMID:17434604 |
|
NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875
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G |
Drd3 |
dopamine receptor D3 |
multiple interactions |
EXP |
Dizocilpine Maleate inhibits the reaction [Excitatory Amino Acid Agents promotes the reaction [CAMK2A protein binds to DRD3 protein]] |
CTD |
PMID:19217379 |
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NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596
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G |
Dusp1 |
dual specificity phosphatase 1 |
multiple interactions |
EXP |
Dizocilpine Maleate inhibits the reaction [Methamphetamine results in increased expression of DUSP1 mRNA] |
CTD |
PMID:11701771 |
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NCBI chr10:16,680,478...16,683,275
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G |
Dusp6 |
dual specificity phosphatase 6 |
multiple interactions |
EXP |
Dizocilpine Maleate inhibits the reaction [Methamphetamine results in increased expression of DUSP6 mRNA] |
CTD |
PMID:11701771 |
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NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185
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G |
Egr1 |
early growth response 1 |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [Zinc results in increased expression of EGR1 protein] |
CTD |
PMID:10428039 |
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NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
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G |
Eif2ak3 |
eukaryotic translation initiation factor 2 alpha kinase 3 |
multiple interactions |
EXP |
Dizocilpine Maleate inhibits the reaction [Cocaine results in increased expression of EIF2AK3 protein] |
CTD |
PMID:17303341 |
|
NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
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G |
Enpp2 |
ectonucleotide pyrophosphatase/phosphodiesterase 2 |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [[ENPP2 protein co-treated with Capsaicin] results in increased abundance of lysophosphatidic acid] |
CTD |
PMID:19014389 |
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NCBI chr 7:86,202,345...86,325,050
Ensembl chr 7:86,202,350...86,324,827
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G |
Ern1 |
endoplasmic reticulum to nucleus signaling 1 |
multiple interactions |
EXP |
Dizocilpine Maleate inhibits the reaction [Cocaine results in increased expression of ERN1 protein] |
CTD |
PMID:17303341 |
|
NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
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G |
Faah |
fatty acid amide hydrolase |
decreases activity |
EXP |
Dizocilpine Maleate results in decreased activity of FAAH protein |
CTD |
PMID:17591864 |
|
NCBI chr 5:129,479,774...129,499,018
Ensembl chr 5:129,479,824...129,498,677
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G |
Fgf2 |
fibroblast growth factor 2 |
increases expression |
EXP |
Dizocilpine Maleate results in increased expression of FGF2 mRNA |
CTD |
PMID:9832142 |
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NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions decreases expression increases expression |
ISO EXP |
[Morphine co-treated with Dizocilpine Maleate] inhibits the reaction [Naloxone results in increased expression of FOS protein]; Dizocilpine Maleate inhibits the reaction [[Kainic Acid co-treated with dihydroxyethyldithiocarbamate] results in increased expression of FOS protein]; Dizocilpine Maleate inhibits the reaction [Haloperidol results in increased expression of FOS protein] Dizocilpine Maleate results in decreased expression of FOS mRNA; Dizocilpine Maleate results in decreased expression of FOS protein Dizocilpine Maleate results in increased expression of FOS mRNA Dizocilpine Maleate inhibits the reaction [Cocaine results in increased expression of FOS protein]; Dizocilpine Maleate inhibits the reaction [Dextroamphetamine results in increased expression of FOS mRNA]; Dizocilpine Maleate inhibits the reaction [Dextromethorphan results in increased expression of FOS protein]; Dizocilpine Maleate inhibits the reaction [Pentylenetetrazole results in increased expression of FOS protein]; Dizocilpine Maleate inhibits the reaction [Pilocarpine results in increased expression of FOS mRNA] |
CTD |
PMID:7984056 PMID:8404677 PMID:11421588 PMID:12401322 PMID:12807422 PMID:15140647 PMID:15196794 PMID:16686654 PMID:18822274 PMID:28916251 More...
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NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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G |
Fosb |
FosB proto-oncogene, AP-1 transcription factor subunit |
increases response to substance |
EXP |
FOSB protein modified form results in increased susceptibility to Dizocilpine Maleate |
CTD |
PMID:24067299 |
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NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465
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G |
Gad1 |
glutamate decarboxylase 1 |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [Oxygen deficiency results in decreased expression of GAD1 protein] |
CTD |
PMID:29107683 |
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NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333
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G |
Gal |
galanin and GMAP prepropeptide |
multiple interactions |
EXP |
Dizocilpine Maleate inhibits the reaction [[Estradiol co-treated with Progesterone] results in increased expression of GAL mRNA] |
CTD |
PMID:8730651 |
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NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:200,650,439...200,654,959
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G |
Gap43 |
growth associated protein 43 |
multiple interactions |
EXP |
Dizocilpine Maleate inhibits the reaction [Kainic Acid results in increased expression of GAP43 mRNA] |
CTD |
PMID:8774942 |
|
NCBI chr11:58,376,371...58,470,047
Ensembl chr11:58,376,371...58,470,045
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G |
Gapdh |
glyceraldehyde-3-phosphate dehydrogenase |
increases expression |
EXP |
Dizocilpine Maleate results in increased expression of GAPDH protein |
CTD |
PMID:21297352 |
|
NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235
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G |
Gfap |
glial fibrillary acidic protein |
multiple interactions |
EXP |
Dizocilpine Maleate inhibits the reaction [diphenylditelluride results in decreased phosphorylation of GFAP protein] |
CTD |
PMID:21863293 |
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NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
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G |
Gria1 |
glutamate ionotropic receptor AMPA type subunit 1 |
multiple interactions |
EXP |
Dizocilpine Maleate inhibits the reaction [Cocaine results in increased expression of GRIA1 protein] |
CTD |
PMID:11801363 |
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NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283
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G |
Grin1 |
glutamate ionotropic receptor NMDA type subunit 1 |
decreases activity affects binding increases expression multiple interactions |
ISO EXP |
Dizocilpine Maleate results in decreased activity of GRIN1 protein Dizocilpine Maleate binds to GRIN1 protein Dizocilpine Maleate results in increased expression of GRIN1 mRNA [GRIN1 protein co-treated with GRIN2A protein] results in increased susceptibility to Dizocilpine Maleate; [GRIN1 protein co-treated with GRIN2B protein] results in increased susceptibility to Dizocilpine Maleate; Dizocilpine Maleate inhibits the reaction [[GRIN1 protein co-treated with GRIN2A protein] results in increased susceptibility to Excitatory Amino Acid Agonists] Dizocilpine Maleate inhibits the reaction [Cocaine results in increased expression of GRIN1 protein]; Dizocilpine Maleate inhibits the reaction [Folic Acid deficiency results in increased expression of GRIN1 protein]; Dizocilpine Maleate promotes the reaction [GRIN1 protein binds to SRC protein] |
CTD |
PMID:11249956 PMID:11801363 PMID:19224577 PMID:19788891 PMID:20406136 PMID:25937004 PMID:31202911 More...
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NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603
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G |
Grin2a |
glutamate ionotropic receptor NMDA type subunit 2A |
multiple interactions increases phosphorylation |
ISO EXP |
Dizocilpine Maleate inhibits the reaction [Formaldehyde results in increased expression of GRIN2A mRNA] Dizocilpine Maleate results in increased phosphorylation of GRIN2A protein [GRIN1 protein co-treated with GRIN2A protein] results in increased susceptibility to Dizocilpine Maleate; Dizocilpine Maleate inhibits the reaction [[GRIN1 protein co-treated with GRIN2A protein] results in increased susceptibility to Excitatory Amino Acid Agonists] Dizocilpine Maleate inhibits the reaction [Folic Acid deficiency results in increased expression of GRIN2A protein] |
CTD |
PMID:11249956 PMID:17434604 PMID:19224577 PMID:20406136 |
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NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637
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G |
Grin2b |
glutamate ionotropic receptor NMDA type subunit 2B |
multiple interactions decreases expression |
EXP ISO |
Dizocilpine Maleate inhibits the reaction [Cocaine results in increased expression of GRIN2B protein]; Dizocilpine Maleate inhibits the reaction [Dextromethorphan results in increased expression of GRIN2B protein] Dizocilpine Maleate results in decreased expression of GRIN2B mRNA [GRIN1 protein co-treated with GRIN2B protein] results in increased susceptibility to Dizocilpine Maleate |
CTD |
PMID:11169168 PMID:11801363 PMID:19224577 PMID:28916251 |
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NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279
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G |
Grin2c |
glutamate ionotropic receptor NMDA type subunit 2C |
decreases expression |
EXP |
Dizocilpine Maleate results in decreased expression of GRIN2C mRNA |
CTD |
PMID:11169168 |
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NCBI chr10:100,488,430...100,507,083
Ensembl chr10:100,488,431...100,506,427
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G |
Gsk3b |
glycogen synthase kinase 3 beta |
multiple interactions increases expression increases phosphorylation |
ISO EXP |
3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Dizocilpine Maleate results in decreased phosphorylation of and results in increased activity of GSK3B protein]; Dizocilpine Maleate results in decreased phosphorylation of and results in increased activity of GSK3B protein; Famotidine inhibits the reaction [Dizocilpine Maleate results in decreased phosphorylation of and results in increased activity of GSK3B protein]; Famotidine inhibits the reaction [Dizocilpine Maleate results in increased expression of GSK3B mRNA]; Olanzapine inhibits the reaction [Dizocilpine Maleate results in increased expression of GSK3B mRNA] Dizocilpine Maleate results in increased phosphorylation of GSK3B protein |
CTD |
PMID:15877933 PMID:31563592 |
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NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
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G |
Hspa1a |
heat shock protein family A (Hsp70) member 1A |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [[Kainic Acid co-treated with dihydroxyethyldithiocarbamate] results in increased expression of HSPA1A protein] |
CTD |
PMID:16686654 |
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NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227
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G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
multiple interactions |
EXP |
Dizocilpine Maleate inhibits the reaction [Cocaine results in increased expression of HSPA5 protein] |
CTD |
PMID:17303341 |
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NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
EXP |
Dizocilpine Maleate inhibits the reaction [Ibotenic Acid results in increased expression of IL1B protein] |
CTD |
PMID:36925032 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il6 |
interleukin 6 |
multiple interactions |
EXP |
Dizocilpine Maleate inhibits the reaction [Ibotenic Acid results in increased expression of IL6 protein] |
CTD |
PMID:36925032 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Inhba |
inhibin subunit beta A |
multiple interactions |
EXP |
Dizocilpine Maleate inhibits the reaction [Ibotenic Acid results in increased expression of INHBA protein] |
CTD |
PMID:36925032 |
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NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
EXP |
Dizocilpine Maleate inhibits the reaction [Pilocarpine results in increased expression of JUN mRNA] |
CTD |
PMID:7984056 |
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NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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G |
Junb |
JunB proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
EXP |
Dizocilpine Maleate inhibits the reaction [[Oxidopamine co-treated with Levodopa] results in increased expression of JUNB mRNA]; Dizocilpine Maleate inhibits the reaction [Pilocarpine results in increased expression of JUNB mRNA] |
CTD |
PMID:7984056 PMID:9890435 |
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NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
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G |
Maoa |
monoamine oxidase A |
multiple interactions |
EXP |
Dizocilpine Maleate inhibits the reaction [ammonium acetate results in increased activity of MAOA protein] |
CTD |
PMID:12885441 |
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NCBI chr X:6,032,172...6,098,308
Ensembl chr X:6,030,795...6,099,593
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions decreases phosphorylation |
ISO EXP |
[Dizocilpine Maleate co-treated with 2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline] inhibits the reaction [Dieldrin results in increased phosphorylation of MAPK1 protein]; Dizocilpine Maleate affects the reaction [Ptychodiscus brevis T2 toxin affects the phosphorylation of MAPK1 protein]; Dizocilpine Maleate inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] results in increased activity of and results in increased phosphorylation of MAPK1 protein]; Dizocilpine Maleate inhibits the reaction [Dronabinol results in increased activity of MAPK1 protein]; Dizocilpine Maleate inhibits the reaction [Dronabinol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Dizocilpine Maleate inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; Dizocilpine Maleate results in decreased phosphorylation of and results in decreased activity of MAPK1 protein Dizocilpine Maleate inhibits the reaction [Excitatory Amino Acid Agonists results in increased phosphorylation of MAPK1 protein] Dizocilpine Maleate inhibits the reaction [Ammonium Chloride results in increased phosphorylation of MAPK1 protein]; Dizocilpine Maleate inhibits the reaction [Capsaicin results in increased phosphorylation of MAPK1 protein] Dizocilpine Maleate results in decreased phosphorylation of MAPK1 protein |
CTD |
PMID:11553284 PMID:11923223 PMID:12657697 PMID:15086530 PMID:15385614 PMID:19850060 PMID:19911010 PMID:21278053 PMID:28987794 More...
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
decreases phosphorylation multiple interactions |
ISO EXP |
Dizocilpine Maleate results in decreased phosphorylation of MAPK3 protein Dizocilpine Maleate inhibits the reaction [Ammonium Chloride results in increased phosphorylation of MAPK3 protein]; Dizocilpine Maleate inhibits the reaction [Capsaicin results in increased phosphorylation of MAPK3 protein] Dizocilpine Maleate inhibits the reaction [Excitatory Amino Acid Agonists results in increased phosphorylation of MAPK3 protein] [Dizocilpine Maleate co-treated with 2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline] inhibits the reaction [Dieldrin results in increased phosphorylation of MAPK3 protein]; Dizocilpine Maleate affects the reaction [Ptychodiscus brevis T2 toxin affects the phosphorylation of MAPK3 protein]; Dizocilpine Maleate inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] results in increased activity of and results in increased phosphorylation of MAPK3 protein]; Dizocilpine Maleate inhibits the reaction [Dronabinol results in increased activity of MAPK3 protein]; Dizocilpine Maleate inhibits the reaction [Dronabinol results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Dizocilpine Maleate inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; Dizocilpine Maleate results in decreased phosphorylation of and results in decreased activity of MAPK3 protein |
CTD |
PMID:11553284 PMID:11923223 PMID:12657697 PMID:15086530 PMID:15385614 PMID:19850060 PMID:19911010 PMID:21278053 PMID:28987794 More...
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mapt |
microtubule-associated protein tau |
multiple interactions |
ISO EXP |
Dizocilpine Maleate inhibits the reaction [Methylmercury Compounds results in increased phosphorylation of MAPT protein] Dizocilpine Maleate inhibits the reaction [D-Aspartic Acid results in decreased expression of and affects the phosphorylation of MAPT protein]; Dizocilpine Maleate inhibits the reaction [D-Aspartic Acid results in decreased phosphorylation of MAPT protein]; Dizocilpine Maleate inhibits the reaction [D-Aspartic Acid results in increased cleavage of MAPT protein] |
CTD |
PMID:21976409 PMID:30822420 |
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NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
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G |
Mfn2 |
mitofusin 2 |
multiple interactions |
EXP |
Dizocilpine Maleate inhibits the reaction [Excitatory Amino Acid Agonists results in decreased expression of MFN2 protein] |
CTD |
PMID:25416777 |
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NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342
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G |
Mmp1 |
matrix metallopeptidase 1 |
multiple interactions |
EXP |
Dizocilpine Maleate inhibits the reaction [Folic Acid deficiency results in decreased expression of MMP1 mRNA]; Dizocilpine Maleate inhibits the reaction [Homocysteine analog results in decreased expression of and results in decreased activity of MMP1 protein] |
CTD |
PMID:20406136 |
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NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
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G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions |
EXP |
Dizocilpine Maleate inhibits the reaction [Folic Acid deficiency results in decreased expression of MMP9 mRNA]; Dizocilpine Maleate inhibits the reaction [Homocysteine analog results in decreased expression of MMP9 protein] |
CTD |
PMID:20406136 |
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NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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G |
Nefl |
neurofilament light chain |
multiple interactions |
EXP |
Dizocilpine Maleate inhibits the reaction [diphenylditelluride results in decreased phosphorylation of NEFL protein]; Dizocilpine Maleate inhibits the reaction [N-Methylaspartate results in decreased expression of NEFL mRNA]; Dizocilpine Maleate inhibits the reaction [Rotenone results in decreased expression of NEFL mRNA] |
CTD |
PMID:21863293 PMID:31969611 |
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NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793
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G |
Nefm |
neurofilament medium chain |
multiple interactions |
EXP |
Dizocilpine Maleate inhibits the reaction [diphenylditelluride results in decreased phosphorylation of NEFM protein] |
CTD |
PMID:21863293 |
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NCBI chr15:42,360,449...42,365,753
Ensembl chr15:42,360,454...42,365,755
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
EXP |
Dizocilpine Maleate inhibits the reaction [Ammonium Chloride results in increased degradation of NFKBIA protein] |
CTD |
PMID:11923223 |
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NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Nme1 |
NME/NM23 nucleoside diphosphate kinase 1 |
increases expression |
EXP |
Dizocilpine Maleate results in increased expression of NME1 protein |
CTD |
PMID:21297352 |
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NCBI chr10:78,907,036...78,929,659
Ensembl chr10:78,906,083...78,916,408
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G |
Nos1 |
nitric oxide synthase 1 |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [decabromobiphenyl ether results in increased expression of NOS1 protein] |
CTD |
PMID:29151189 |
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NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
EXP |
Dizocilpine Maleate inhibits the reaction [Ammonium Chloride results in increased expression of NOS2 protein] |
CTD |
PMID:11923223 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Nps |
neuropeptide S |
decreases activity multiple interactions |
EXP |
NPS protein results in decreased activity of Dizocilpine Maleate 3-oxo-1,1-diphenyltetrahydrooxazolo(3,4-a)pyrazine-7-carboxylic acid 4-fluorobenzylamide inhibits the reaction [NPS protein results in decreased activity of Dizocilpine Maleate] |
CTD |
PMID:21466221 |
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NCBI chr 1:190,077,040...190,080,821
Ensembl chr 1:190,077,040...190,080,821
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G |
Nsf |
N-ethylmaleimide sensitive factor, vesicle fusing ATPase |
increases expression |
EXP |
Dizocilpine Maleate results in increased expression of NSF protein |
CTD |
PMID:21297352 |
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NCBI chr10:88,727,912...88,857,375
Ensembl chr10:88,727,912...88,857,386
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G |
Ocln |
occludin |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [Excitatory Amino Acid Agonists results in decreased expression of OCLN protein] |
CTD |
PMID:26655082 |
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NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150
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G |
Oprm1 |
opioid receptor, mu 1 |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCA protein]]; Dizocilpine Maleate inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]] |
CTD |
PMID:18652891 |
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NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions |
EXP |
Dizocilpine Maleate inhibits the reaction [ammonium acetate results in increased expression of PARP1 protein] |
CTD |
PMID:15147502 |
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NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Pde2a |
phosphodiesterase 2A |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [decabromobiphenyl ether results in increased expression of PDE2A mRNA] |
CTD |
PMID:29151189 |
|
NCBI chr 1:155,823,590...155,915,434
Ensembl chr 1:155,813,180...155,915,434
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G |
Pde5a |
phosphodiesterase 5A |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [decabromobiphenyl ether results in increased expression of PDE5A mRNA] |
CTD |
PMID:29151189 |
|
NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:210,858,063...210,999,701
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G |
Penk |
proenkephalin |
multiple interactions |
EXP |
Dizocilpine Maleate inhibits the reaction [Amphetamine results in increased expression of PENK mRNA] |
CTD |
PMID:12850537 |
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NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129
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G |
Pomc |
proopiomelanocortin |
multiple interactions |
EXP |
Dizocilpine Maleate inhibits the reaction [Capsaicin results in increased secretion of POMC protein] |
CTD |
PMID:8925284 |
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NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
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G |
Prkca |
protein kinase C, alpha |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCA protein]] |
CTD |
PMID:18652891 |
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NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
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G |
Prkcg |
protein kinase C, gamma |
increases expression multiple interactions |
EXP ISO |
Dizocilpine Maleate results in increased expression of PRKCG mRNA Dizocilpine Maleate inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]] |
CTD |
PMID:11169168 PMID:18652891 |
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NCBI chr 1:65,832,851...65,860,676
Ensembl chr 1:65,832,855...65,859,384
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G |
Prl |
prolactin |
decreases expression |
EXP |
Dizocilpine Maleate results in decreased expression of PRL protein |
CTD |
PMID:8404677 |
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NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
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G |
Prodh |
proline dehydrogenase |
affects response to substance |
ISO |
PRODH protein affects the susceptibility to Dizocilpine Maleate |
CTD |
PMID:16234811 |
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NCBI chr11:82,910,043...82,927,305
Ensembl chr11:82,910,137...82,927,305
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] |
CTD |
PMID:15987631 |
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NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Ptn |
pleiotrophin |
multiple interactions |
EXP |
Dizocilpine Maleate promotes the reaction [Amphetamine results in increased expression of PTN mRNA] |
CTD |
PMID:15862925 |
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NCBI chr 4:65,293,731...65,375,572
Ensembl chr 4:65,293,734...65,375,456
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G |
Rac1 |
Rac family small GTPase 1 |
multiple interactions |
EXP |
Dizocilpine Maleate inhibits the reaction [bisphenol A results in increased expression of RAC1 protein]; Dizocilpine Maleate inhibits the reaction [Estradiol results in increased expression of RAC1 protein] |
CTD |
PMID:24231043 |
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NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251
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G |
Rara |
retinoic acid receptor, alpha |
multiple interactions |
EXP |
Dizocilpine Maleate inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] promotes the reaction [Alitretinoin results in increased activity of RARA protein]] |
CTD |
PMID:15773917 |
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NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142
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G |
Rhoa |
ras homolog family member A |
multiple interactions |
EXP |
Dizocilpine Maleate inhibits the reaction [bisphenol A results in decreased expression of RHOA protein]; Dizocilpine Maleate inhibits the reaction [Estradiol results in decreased expression of RHOA protein] |
CTD |
PMID:24231043 |
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NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
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G |
Sirt1 |
sirtuin 1 |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein]; Dizocilpine Maleate inhibits the reaction [N-Methylaspartate results in decreased expression of SIRT1 mRNA] |
CTD |
PMID:31945382 |
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NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
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G |
Sod2 |
superoxide dismutase 2 |
multiple interactions |
EXP |
Dizocilpine Maleate inhibits the reaction [ammonium acetate results in decreased activity of SOD2 protein] |
CTD |
PMID:12885441 |
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NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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G |
Src |
SRC proto-oncogene, non-receptor tyrosine kinase |
multiple interactions increases expression increases activity |
EXP |
Dizocilpine Maleate promotes the reaction [GRIN1 protein binds to SRC protein]; Dizocilpine Maleate results in increased phosphorylation of and results in increased activity of SRC protein Dizocilpine Maleate results in increased expression of SRC mRNA; Dizocilpine Maleate results in increased expression of SRC protein Dizocilpine Maleate results in increased activity of SRC protein |
CTD |
PMID:11249956 |
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NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
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G |
Sst |
somatostatin |
decreases expression multiple interactions |
EXP |
Dizocilpine Maleate results in decreased expression of SST mRNA; Dizocilpine Maleate results in decreased expression of SST protein Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of SST mRNA]; Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of SST protein] |
CTD |
PMID:16567023 |
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NCBI chr11:76,956,896...76,958,173
Ensembl chr11:76,956,896...76,958,173
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G |
Tac1 |
tachykinin, precursor 1 |
multiple interactions |
EXP |
Dizocilpine Maleate inhibits the reaction [[Lithium co-treated with Pilocarpine] results in increased expression of TAC1 protein modified form] |
CTD |
PMID:11074153 |
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NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
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G |
Tgfa |
transforming growth factor alpha |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [Lipopolysaccharides results in increased secretion of TGFA] |
CTD |
PMID:15987631 |
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NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894
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G |
Timp1 |
TIMP metallopeptidase inhibitor 1 |
multiple interactions |
EXP |
Dizocilpine Maleate inhibits the reaction [Homocysteine analog results in increased expression of TIMP1 mRNA]; Dizocilpine Maleate inhibits the reaction [Homocysteine analog results in increased expression of TIMP1 protein] |
CTD |
PMID:20406136 |
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NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
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G |
Tjp1 |
tight junction protein 1 |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [N-Methylaspartate results in decreased expression of TJP1 mRNA]; Dizocilpine Maleate inhibits the reaction [N-Methylaspartate results in decreased expression of TJP1 protein] |
CTD |
PMID:35257817 |
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NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
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G |
Tpi1 |
triosephosphate isomerase 1 |
increases expression |
EXP |
Dizocilpine Maleate results in increased expression of TPI1 protein |
CTD |
PMID:21297352 |
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NCBI chr 4:157,615,283...157,618,813
Ensembl chr 4:157,615,386...157,619,541
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G |
Vim |
vimentin |
multiple interactions |
EXP |
Dizocilpine Maleate inhibits the reaction [diphenylditelluride results in decreased phosphorylation of VIM protein] |
CTD |
PMID:21863293 |
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NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
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G |
Xdh |
xanthine dehydrogenase |
multiple interactions |
EXP |
Dizocilpine Maleate inhibits the reaction [ammonium acetate affects the activity of XDH protein] |
CTD |
PMID:12885441 |
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NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
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