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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:FINO2
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Accession:CHEBI:176420 term browser browse the term
Definition:An oxaspiro compound that is 1,2-dioxaspiro[4.5]decane substituted by methyl, 2-hydroxyethyl and tert-butyl groups at positions 3, 3 and 8, respectivey (the 5s,8s-stereoisomer). It induces ferroptosis in cancer cells by indirectly inhibiting glutathione peroxidase 4 (GPX4) enzymatic function and directly oxidizes iron leading to widespread lipid peroxidation.
Synonyms:exact_synonym: 2-[(5s,8s)-8-tert-butyl-3-methyl-1,2-dioxaspiro[4.5]decan-3-yl]ethanol
 related_synonym: 2-[(5s,8s)-8-tert-butyl-3-methyl-1,2-dioxaspiro[4.5]decan-3-yl]ethan-1-ol;   Formula=C15H28O3;   InChI=1S/C15H28O3/c1-13(2,3)12-5-7-15(8-6-12)11-14(4,9-10-16)17-18-15/h12,16H,5-11H2,1-4H3/t12-,14?,15+;   InChIKey=RWJLCLCUNHUSPG-NNUVIIOVSA-N;   SMILES=CC(C)(C)[C@H]1CC[C@]2(CC(C)(CCO)OO2)CC1
 xref: CAS:869298-31-7;   PMID:16209493;   PMID:26797166;   PMID:29610484


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  CHEBI ontology 19899
    role 19869
      biological role 19867
        biochemical role 19574
          ferroptosis inducer 15760
            FINO2 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19899
    subatomic particle 19897
      composite particle 19897
        hadron 19897
          baryon 19897
            nucleon 19897
              atomic nucleus 19897
                atom 19897
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19776
                        carbon atom 19772
                          organic molecular entity 19772
                            organic molecule 19724
                              organic cyclic compound 19514
                                organic heterocyclic compound 18893
                                  organic heteropolycyclic compound 18320
                                    organic heterobicyclic compound 17272
                                      FINO2 0
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