Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:phorbol 12,13-dibutanoate
go back to main search page
Accession:CHEBI:17598 term browser browse the term
Definition:A phorbol ester that has formula C28H40O8.
Synonyms:exact_synonym: (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-9aH-cyclopropa[3,4]benzo[1,2-e]azulene-9,9a-diyl dibutanoate
 related_synonym: Formula=C28H40O8;   InChI=1S/C28H40O8/c1-7-9-20(30)35-24-16(4)27(34)18(22-25(5,6)28(22,24)36-21(31)10-8-2)12-17(14-29)13-26(33)19(27)11-15(3)23(26)32/h11-12,16,18-19,22,24,29,33-34H,7-10,13-14H2,1-6H3/t16-,18+,19-,22-,24-,26-,27-,28-/m1/s1;   InChIKey=BQJRUJTZSGYBEZ-YVQNUNKESA-N;   PDBu;   SMILES=[H][C@@]12C=C(CO)C[C@]3(O)C(=O)C(C)=C[C@@]3([H])[C@@]1(O)[C@H](C)[C@@H](OC(=O)CCC)[C@]1(OC(=O)CCC)[C@@]2([H])C1(C)C;   phorbol 12,13-dibutyrate
 alt_id: CHEBI:14789;   CHEBI:26015;   CHEBI:8117;   CHEBI:8120
 xref: Beilstein:6551234;   CAS:37558-16-0;   KEGG:C03634
 xref_mesh: MESH:D015240


show annotations for term's descendants           Sort by:
phorbol 12,13-dibutanoate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam10 ADAM metallopeptidase domain 10 increases expression ISO Phorbol 12,13-Dibutyrate results in increased expression of ADAM10 protein CTD PMID:19476501 NCBI chr 8:71,346,008...71,477,889
Ensembl chr 8:71,345,837...71,477,889 		JBrowse link
G Adam9 ADAM metallopeptidase domain 9 increases expression ISO Phorbol 12,13-Dibutyrate results in increased expression of ADAM9 protein CTD PMID:19476501 NCBI chr16:67,022,538...67,101,647
Ensembl chr16:67,022,655...67,100,917 		JBrowse link
G App amyloid beta precursor protein increases secretion
multiple interactions		 ISO Phorbol 12,13-Dibutyrate results in increased secretion of APP protein modified form
Go 6976 inhibits the reaction [Phorbol 12,13-Dibutyrate results in increased secretion of APP protein modified form]		 CTD PMID:19476501 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Bace1 beta-secretase 1 multiple interactions
affects localization		 ISO Go 6976 inhibits the reaction [Phorbol 12,13-Dibutyrate affects the localization of BACE1 protein] CTD PMID:19476501 NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876 		JBrowse link
G Casp9 caspase 9 increases cleavage
multiple interactions		 ISO Phorbol 12,13-Dibutyrate results in increased cleavage of CASP9 protein
rottlerin inhibits the reaction [Phorbol 12,13-Dibutyrate results in increased cleavage of CASP9 protein]		 CTD PMID:12626342 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression		 ISO Phorbol 12,13-Dibutyrate inhibits the reaction [alvocidib inhibits the reaction [romidepsin results in increased expression of CDKN1A protein]]
Phorbol 12,13-Dibutyrate results in increased expression of CDKN1A protein		 CTD PMID:15014036 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Phorbol 12,13-Dibutyrate inhibits the reaction [Asbestos, Crocidolite results in increased expression of FOS mRNA]; Phorbol 12,13-Dibutyrate inhibits the reaction [Lead results in increased expression of FOS mRNA]; Phorbol 12,13-Dibutyrate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of FOS mRNA] CTD PMID:9242432 PMID:10693946 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A multiple interactions EXP Phorbol 12,13-Dibutyrate inhibits the reaction [N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno(1,2-c)pyrazole-3-carboxamide results in increased expression of HTR2A mRNA] CTD PMID:22791651 NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928 		JBrowse link
G Il12a interleukin 12A increases expression ISO Phorbol 12,13-Dibutyrate results in increased expression of IL12A mRNA CTD PMID:15516327 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734 		JBrowse link
G Il12b interleukin 12B increases expression ISO Phorbol 12,13-Dibutyrate results in increased expression of IL12B mRNA CTD PMID:15516327 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il23a interleukin 23 subunit alpha increases expression ISO Phorbol 12,13-Dibutyrate results in increased expression of IL23A mRNA CTD PMID:15516327 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Phorbol 12,13-Dibutyrate inhibits the reaction [Asbestos, Crocidolite results in increased expression of JUN mRNA]; Phorbol 12,13-Dibutyrate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of JUN mRNA] CTD PMID:9242432 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Phorbol 12,13-Dibutyrate inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; Phorbol 12,13-Dibutyrate promotes the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein] CTD PMID:16251475 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Phorbol 12,13-Dibutyrate inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; Phorbol 12,13-Dibutyrate promotes the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein] CTD PMID:16251475 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mmp9 matrix metallopeptidase 9 increases activity
multiple interactions		 ISO Phorbol 12,13-Dibutyrate results in increased activity of MMP9 protein
Quercetin inhibits the reaction [Phorbol 12,13-Dibutyrate results in increased activity of MMP9 protein]		 CTD PMID:14593496 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Myl9 myosin light chain 9 multiple interactions
increases phosphorylation		 EXP 2-methyl-1-((4-methyl-5-isoquinolinyl)sulfonyl)homopiperazine inhibits the reaction [Phorbol 12,13-Dibutyrate results in increased phosphorylation of MYL9 protein] CTD PMID:18986333 NCBI chr 3:145,281,943...145,288,333
Ensembl chr 3:145,281,937...145,288,333 		JBrowse link
G Ppp1r12a protein phosphatase 1, regulatory subunit 12A increases phosphorylation EXP Phorbol 12,13-Dibutyrate results in increased phosphorylation of PPP1R12A protein CTD PMID:18986333 NCBI chr 7:43,482,808...43,593,689
Ensembl chr 7:43,482,803...43,593,425 		JBrowse link
G Ppp1r14a protein phosphatase 1, regulatory (inhibitor) subunit 14A multiple interactions
increases phosphorylation		 EXP 2-methyl-1-((4-methyl-5-isoquinolinyl)sulfonyl)homopiperazine inhibits the reaction [Phorbol 12,13-Dibutyrate results in increased phosphorylation of PPP1R14A protein]; Ro 31-8220 inhibits the reaction [Phorbol 12,13-Dibutyrate results in increased phosphorylation of PPP1R14A protein] CTD PMID:18986333 NCBI chr 1:84,583,127...84,590,743
Ensembl chr 1:84,586,627...84,590,671 		JBrowse link
G Prkca protein kinase C, alpha decreases expression
increases expression
multiple interactions		 ISO
EXP		 Phorbol 12,13-Dibutyrate results in decreased expression of PRKCA protein
Phorbol 12,13-Dibutyrate results in increased expression of PRKCA protein
Phorbol 12,13-Dibutyrate results in decreased expression of and affects the localization of PRKCA protein		 CTD PMID:9242432 PMID:12626342 PMID:17171646 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012 		JBrowse link
G Prkcd protein kinase C, delta increases expression
affects binding
affects localization		 ISO Phorbol 12,13-Dibutyrate results in increased expression of PRKCD protein
Phorbol 12,13-Dibutyrate binds to PRKCD protein
Phorbol 12,13-Dibutyrate affects the localization of PRKCD protein		 CTD PMID:8106444 PMID:12057904 PMID:12626342 NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352 		JBrowse link
G Prkce protein kinase C, epsilon affects binding ISO Phorbol 12,13-Dibutyrate binds to PRKCE protein CTD PMID:8106444 NCBI chr 6:7,965,048...8,451,966
Ensembl chr 6:7,965,048...8,451,719 		JBrowse link
G Prkcz protein kinase C, zeta increases expression ISO Phorbol 12,13-Dibutyrate results in increased expression of PRKCZ protein CTD PMID:12626342 NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367 		JBrowse link
G Psen1 presenilin 1 multiple interactions
increases expression		 ISO Go 6976 inhibits the reaction [Phorbol 12,13-Dibutyrate results in increased expression of PSEN1 protein]
Phorbol 12,13-Dibutyrate results in increased expression of PSEN1 protein; Phorbol 12,13-Dibutyrate results in increased expression of PSEN1 protein modified form		 CTD PMID:19476501 NCBI chr 6:103,323,052...103,375,088
Ensembl chr 6:103,323,120...103,371,650 		JBrowse link
G Rhoa ras homolog family member A increases expression
multiple interactions		 EXP Phorbol 12,13-Dibutyrate results in increased expression of RHOA protein modified form
Ro 31-8220 inhibits the reaction [Phorbol 12,13-Dibutyrate results in increased expression of RHOA protein modified form]		 CTD PMID:18986333 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746 		JBrowse link
G Slc22a25 solute carrier family 22, member 25 affects localization
multiple interactions
decreases activity		 ISO Phorbol 12,13-Dibutyrate affects the localization of SLC22A9 protein
Staurosporine inhibits the reaction [Phorbol 12,13-Dibutyrate affects the localization of SLC22A9 protein]; Staurosporine inhibits the reaction [Phorbol 12,13-Dibutyrate results in decreased activity of SLC22A9 protein]		 CTD PMID:17341544 NCBI chr 1:205,338,698...205,498,486
Ensembl chr 1:205,338,699...205,433,085 		JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions EXP Phorbol 12,13-Dibutyrate promotes the reaction [Capsaicin results in increased secretion of TAC1 protein]; Pregabalin inhibits the reaction [Phorbol 12,13-Dibutyrate promotes the reaction [Capsaicin results in increased secretion of TAC1 protein]] CTD PMID:14499429 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions EXP [alpha-Linolenic Acid co-treated with Phorbol 12,13-Dibutyrate] results in increased activity of TRPV1 protein; [Arachidonic Acid co-treated with Phorbol 12,13-Dibutyrate] results in increased activity of TRPV1 protein; [Docosahexaenoic Acids co-treated with Phorbol 12,13-Dibutyrate] results in increased activity of TRPV1 protein modified form; [Eicosapentaenoic Acid co-treated with Phorbol 12,13-Dibutyrate] results in increased activity of TRPV1 protein modified form; capsazepine inhibits the reaction [[Docosahexaenoic Acids co-treated with Phorbol 12,13-Dibutyrate] results in increased activity of TRPV1 protein modified form]; capsazepine inhibits the reaction [[Eicosapentaenoic Acid co-treated with Phorbol 12,13-Dibutyrate] results in increased activity of TRPV1 protein modified form]; Linolenic Acids promotes the reaction [[Docosahexaenoic Acids co-treated with Phorbol 12,13-Dibutyrate] results in increased activity of TRPV1 protein modified form] CTD PMID:17038422 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19899
    chemical entity 19897
      molecular entity 19897
        polyatomic entity 19849
          heteroatomic molecular entity 19806
            hydroxides 19366
              organic hydroxy compound 18975
                alpha-hydroxy ketone 8920
                  tertiary alpha-hydroxy ketone 8622
                    phorbol 12,13-dibutanoate 27
Path 2
Term Annotations click to browse term
  CHEBI ontology 19899
    subatomic particle 19897
      composite particle 19897
        hadron 19897
          baryon 19897
            nucleon 19897
              atomic nucleus 19897
                atom 19897
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19776
                        carbon atom 19772
                          organic molecular entity 19772
                            heteroorganic entity 19532
                              organochalcogen compound 19293
                                organooxygen compound 19209
                                  carbon oxoacid 18678
                                    carboxylic acid 18675
                                      monocarboxylic acid 18027
                                        fatty acid 16860
                                          short-chain fatty acid 15941
                                            fatty acid 4:0 8237
                                              butyric acid 6735
                                                butyrate ester 2151
                                                  phorbol 12,13-dibutanoate 27
paths to the root