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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:inosine
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Accession:CHEBI:17596 term browser browse the term
Definition:A purine nucleoside in which hypoxanthine is attached to ribofuranose via a beta-N(9)-glycosidic bond.
Synonyms:exact_synonym: (2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-hydroxy-9H-purin-9-yl)tetrahydrofuran-3,4-diol
 related_synonym: 9-beta-D-ribofuranosyl-9H-purin-6-ol;   9-beta-D-ribofuranosylhypoxanthine;   Formula=C10H12N4O5;   InChI=1S/C10H12N4O5/c15-1-4-6(16)7(17)10(19-4)14-3-13-5-8(14)11-2-12-9(5)18/h2-4,6-7,10,15-17H,1H2,(H,11,12,18)/t4-,6-,7-,10-/m1/s1;   InChIKey=UGQMRVRMYYASKQ-KQYNXXCUSA-N;   Inosin;   SMILES=OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(O)ncnc12;   hypoxanthine D-riboside;   hypoxanthosine;   i;   inosina;   inosinum
 alt_id: CHEBI:14456;   CHEBI:24841;   CHEBI:44407;   CHEBI:5927
 xref: Beilstein:624889;   CAS:58-63-9;   Drug_Central:3301;   ECMDB:ECMDB00195;   Gmelin:489332;   HMDB:HMDB0000195;   KEGG:C00294;   KEGG:D00054;   KNApSAcK:C00019692
 xref_mesh: MESH:D007288
 xref: MetaCyc:INOSINE;   PDBeChem:NOS;   PMID:22770225;   Reaxys:624889;   Wikipedia:Inosine;   YMDB:YMDB00510


show annotations for term's descendants           Sort by:
inosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase decreases abundance
increases abundance		 ISO ADA alternative form results in decreased abundance of Inosine
ADA protein results in increased abundance of Inosine		 CTD PMID:16221767 NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088 		JBrowse link
G Faslg Fas ligand increases expression ISO Inosine results in increased expression of FASLG protein CTD PMID:16419169 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO Inosine inhibits the reaction [Cesium-137 results in increased expression of and affects the localization of H2AX protein modified form] CTD PMID:32941855 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G Slc29a1 solute carrier family 29 member 1 multiple interactions ISO
EXP		 Inosine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine] CTD PMID:9353301 PMID:11085929 NCBI chr 9:15,399,661...15,414,203
Ensembl chr 9:15,399,612...15,414,203 		JBrowse link
G Slc29a2 solute carrier family 29 member 2 multiple interactions ISO Inosine inhibits the reaction [SLC29A2 protein results in increased uptake of Uridine] CTD PMID:11085929 NCBI chr 1:202,327,641...202,335,185
Ensembl chr 1:202,327,354...202,335,171 		JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 multiple interactions ISO Inosine inhibits the reaction [Cesium-137 results in increased expression of and affects the localization of TP53BP1 protein] CTD PMID:32941855 NCBI chr 3:108,166,574...108,270,229
Ensembl chr 3:108,169,980...108,269,822 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19922
    role 19894
      biological role 19864
        biochemical role 19596
          metabolite 19558
            fundamental metabolite 14541
              hypoxanthine 23
                inosine 6
                  1-methylinosine 0
                  2'-O-methylinosine 0
                  2'-deoxyinosine 0
                  3',5'-cyclic IMP 0
                  5'-S-methyl-5'-thioinosine 0
                  5'-deoxyinosine 0
                  6-O-methylinosine 0
                  6-deoxyinosine 5'-phosphate 0
                  7-methylinosine 0
                  Phosphoric acid mono-[(2R,3S,4R,5R)-5-(6-amino-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl] ester 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19922
    subatomic particle 19892
      composite particle 19892
        hadron 19920
          baryon 19892
            nucleon 19920
              atomic nucleus 19892
                atom 19892
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19805
                        carbon atom 19802
                          organic molecular entity 19775
                            heteroorganic entity 19556
                              organochalcogen compound 19315
                                organooxygen compound 19205
                                  carbohydrates and carbohydrate derivatives 15294
                                    carbohydrate 15294
                                      carbohydrate derivative 14304
                                        glycosyl compound 13062
                                          N-glycosyl compound 5827
                                            nucleoside 5685
                                              ribonucleoside 1141
                                                purine ribonucleoside 812
                                                  purines D-ribonucleoside 415
                                                    inosine 6
                                                      1-methylinosine 0
                                                      2'-O-methylinosine 0
                                                      2'-deoxyinosine 0
                                                      3',5'-cyclic IMP 0
                                                      5'-S-methyl-5'-thioinosine 0
                                                      5'-deoxyinosine 0
                                                      6-O-methylinosine 0
                                                      6-deoxyinosine 5'-phosphate 0
                                                      7-methylinosine 0
                                                      Phosphoric acid mono-[(2R,3S,4R,5R)-5-(6-amino-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl] ester 0
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