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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:gemcitabine
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Accession:CHEBI:175901 term browser browse the term
Definition:A 2'-deoxycytidine having geminal fluoro substituents in the 2'-position. An inhibitor of ribonucleotide reductase, gemcitabine is used in the treatment of various carcinomas, particularly non-small cell lung cancer, pancreatic cancer, bladder cancer and breast cancer.
Synonyms:related_synonym: 2',2'-Difluorodeoxycytidine;   2'-Deoxy-2',2'-difluorocytidine;   4-amino-1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)pyrimidin-2(1H)-one;   Formula=C9H11F2N3O4;   InChI=1S/C9H11F2N3O4/c10-9(11)6(16)4(3-15)18-7(9)14-2-1-5(12)13-8(14)17/h1-2,4,6-7,15-16H,3H2,(H2,12,13,17)/t4-,6-,7-/m1/s1;   InChIKey=SDUQYLNIPVEERB-QPPQHZFASA-N;   SMILES=Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)C2(F)F)c(=O)n1;   gemcitabina;   gemcitabinum
 alt_id: CHEBI:42752;   CHEBI:5295
 xref: Beilstein:5382060;   CAS:95058-81-4;   DrugBank:DB00441;   Drug_Central:1283;   KEGG:C07650;   KEGG:D02368;   LINCS:LSM-5333
 xref_mesh: MESH:C056507
 xref: PDBeChem:GEO;   PMID:11034044;   PMID:11061612;   PMID:11088063;   PMID:11122828;   PMID:11132538;   PMID:11142482;   PMID:11221019;   PMID:11356111;   PMID:11374818;   PMID:11489002;   PMID:11504793;   PMID:11510027;   PMID:11585734;   PMID:11595724;   PMID:11807603;   PMID:11859947;   PMID:11901308;   PMID:12057041;   PMID:12057046;   PMID:12057157;   PMID:12115355;   PMID:12142097;   PMID:12520460;   PMID:12571808;   PMID:12722678;   PMID:12722691;   PMID:12743987;   PMID:12761494;   PMID:12798170;   PMID:12917815;   PMID:12954073;   PMID:14606642;   PMID:14653877;   PMID:14720338;   PMID:15131028;   PMID:15160243;   PMID:15221904;   PMID:15282439;   PMID:15297392;   PMID:15542781;   PMID:15637766;   PMID:15744590;   PMID:16001951;   PMID:16041610;   PMID:16080557;   PMID:16143373;   PMID:16149285;   PMID:16317298;   PMID:16500746;   PMID:16555971;   PMID:16584929;   PMID:16807461;   PMID:16807463;   PMID:16894289;   PMID:16905983;   PMID:17101674;   PMID:17296311;   PMID:17296587;   PMID:17347561;   PMID:17429628;   PMID:17460420;   PMID:17602464;   PMID:17639396;   PMID:17887663;   PMID:17939651;   PMID:17941128;   PMID:17987263;   PMID:18035967;   PMID:18050344;   PMID:18086345;   PMID:18166944;   PMID:18186604;   PMID:18257544;   PMID:18348652;   PMID:18773046;   PMID:18789834;   PMID:18819792;   PMID:18981552;   PMID:19034448;   PMID:19177022;   PMID:19399788;   PMID:19839926;   PMID:19879060;   PMID:22763439;   PMID:28594276;   PMID:28608357;   PMID:28912244;   Patent:EP1939198;   Patent:EP2108368;   Patent:EP2275135;   Patent:GB2136425;   Patent:US2009124797;   Patent:US2010111852;   Patent:US4808614;   Reaxys:5382060;   Wikipedia:Gemcitabine


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gemcitabine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin increases expression ISO Gemcitabine results in increased expression of A2M protein CTD PMID:20531411 NCBI chr 4:156,570,163...156,619,870
Ensembl chr 4:156,569,860...156,619,868 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A decreases expression ISO Gemcitabine results in decreased expression of ABCB1 mRNA; Gemcitabine results in decreased expression of ABCB1 protein CTD PMID:35063459 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135 		JBrowse link
G Acp3 acid phosphatase 3 decreases expression ISO Gemcitabine results in decreased expression of ACP3 protein CTD PMID:20531411 NCBI chr 8:113,784,372...113,833,033
Ensembl chr 8:113,785,032...113,833,033 		JBrowse link
G Adam17 ADAM metallopeptidase domain 17 multiple interactions ISO ADAM17 protein promotes the reaction [Gemcitabine results in increased cleavage of AREG protein] CTD PMID:20726858 NCBI chr 6:46,601,583...46,663,690
Ensembl chr 6:46,601,583...46,649,344 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression ISO Gemcitabine results in increased expression of ADIPOQ protein CTD PMID:20531411 NCBI chr11:91,226,524...91,240,244
Ensembl chr11:91,226,180...91,240,169 		JBrowse link
G Afp alpha-fetoprotein decreases expression ISO Gemcitabine results in decreased expression of AFP protein CTD PMID:20531411 NCBI chr14:17,857,584...17,875,645
Ensembl chr14:17,857,584...17,875,649 		JBrowse link
G Agpat2 1-acylglycerol-3-phosphate O-acyltransferase 2 decreases expression ISO Gemcitabine results in decreased expression of AGPAT2 mRNA CTD PMID:17039268 NCBI chr 3:29,814,924...29,826,569
Ensembl chr 3:29,814,924...29,826,581 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 affects response to substance
multiple interactions 		ISO AKT1 protein affects the susceptibility to Gemcitabine
[Gemcitabine co-treated with licoricidin] results in decreased phosphorylation of AKT1 protein; [licoricidin co-treated with Gemcitabine] results in decreased phosphorylation of AKT1 protein 		CTD PMID:15867245 PMID:29782821 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 multiple interactions
decreases expression 		ISO sulforaphane promotes the reaction [Gemcitabine results in decreased expression of ALDH1A1 protein] CTD PMID:20940707 NCBI chr 1:227,426,939...227,579,497
Ensembl chr 1:227,427,070...227,579,500 		JBrowse link
G Aldh1a3 aldehyde dehydrogenase 1 family, member A3 increases expression ISO Gemcitabine results in increased expression of ALDH1A3 mRNA CTD PMID:17039268 NCBI chr 1:129,392,516...129,436,552
Ensembl chr 1:129,392,516...129,427,777 		JBrowse link
G Aldh6a1 aldehyde dehydrogenase 6 family, member A1 increases expression ISO Gemcitabine results in increased expression of ALDH6A1 mRNA CTD PMID:17039268 NCBI chr 6:109,809,092...109,829,725
Ensembl chr 6:109,809,122...109,829,743 		JBrowse link
G Anapc1 anaphase promoting complex subunit 1 increases expression ISO Gemcitabine results in increased expression of ANAPC1 mRNA CTD PMID:17039268 NCBI chr 3:136,303,350...136,383,464
Ensembl chr 3:136,303,413...136,383,464 		JBrowse link
G Ank3 ankyrin 3 increases expression ISO Gemcitabine results in increased expression of ANK3 mRNA CTD PMID:17039268 NCBI chr20:18,601,307...19,224,790
Ensembl chr20:18,601,826...19,084,879 		JBrowse link
G Ankrd1 ankyrin repeat domain 1 increases expression ISO Gemcitabine results in increased expression of ANKRD1 mRNA CTD PMID:17039268 NCBI chr 1:243,228,460...243,237,014
Ensembl chr 1:243,228,448...243,263,751 		JBrowse link
G Antxr1 ANTXR cell adhesion molecule 1 affects expression ISO Gemcitabine affects the expression of ANTXR1 mRNA CTD PMID:17039268 NCBI chr 4:121,148,102...121,335,549
Ensembl chr 4:121,148,103...121,336,892 		JBrowse link
G Apcs amyloid P component, serum decreases expression ISO Gemcitabine results in decreased expression of APCS protein CTD PMID:20531411 NCBI chr13:87,905,532...87,906,508
Ensembl chr13:87,905,532...87,928,824 		JBrowse link
G Apoh apolipoprotein H increases expression ISO Gemcitabine results in increased expression of APOH protein CTD PMID:20531411 NCBI chr10:93,841,992...93,855,897
Ensembl chr10:93,841,966...93,857,127 		JBrowse link
G Ar androgen receptor multiple interactions ISO Gemcitabine binds to and results in decreased activity of AR protein CTD PMID:25752796 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:67,135,317...67,304,467 		JBrowse link
G Areg amphiregulin multiple interactions
increases expression
increases cleavage
decreases response to substance 		ISO ADAM17 protein promotes the reaction [Gemcitabine results in increased cleavage of AREG protein]
Gemcitabine results in increased expression of AREG protein
AREG protein results in decreased susceptibility to Gemcitabine 		CTD PMID:20726858 NCBI chr14:17,256,384...17,265,641
Ensembl chr14:17,256,384...17,265,641 		JBrowse link
G Arf1 ARF GTPase 1 decreases expression ISO Gemcitabine results in decreased expression of ARF1 mRNA CTD PMID:17039268 NCBI chr10:44,497,543...44,513,994 JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator increases expression ISO Gemcitabine results in increased expression of ARNT mRNA CTD PMID:20103597 NCBI chr 2:185,686,703...185,745,546
Ensembl chr 2:185,680,683...185,745,546 		JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Gemcitabine results in increased expression of ATF3 mRNA CTD PMID:17039268 NCBI chr13:105,274,103...105,331,653
Ensembl chr13:105,282,440...105,295,750 		JBrowse link
G Axin2 axin 2 affects expression ISO Gemcitabine affects the expression of AXIN2 mRNA CTD PMID:20103597 NCBI chr10:94,393,379...94,426,579
Ensembl chr10:94,395,909...94,426,575 		JBrowse link
G Axl Axl receptor tyrosine kinase multiple interactions ISO AXL protein promotes the reaction [Warfarin results in increased susceptibility to Gemcitabine] CTD PMID:26206560 NCBI chr 1:90,392,864...90,424,123
Ensembl chr 1:90,392,864...90,424,009 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [alvocidib co-treated with Gemcitabine] results in increased expression of BAX protein; [ICI 118551 co-treated with Gemcitabine] results in increased expression of BAX protein; [Mastic Resin co-treated with Gemcitabine] results in increased expression of BAX protein; [TNFSF10 co-treated with Gemcitabine] affects the localization of BAX protein CTD PMID:15770523 PMID:17671697 PMID:20523344 PMID:21570961 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions 		ISO Gemcitabine results in decreased expression of BCL2 protein
[alvocidib co-treated with Gemcitabine] results in decreased expression of BCL2 protein; [Aminophylline co-treated with Gemcitabine] results in decreased expression of BCL2 protein; [ICI 118551 co-treated with Gemcitabine] results in decreased expression of BCL2 protein; [Mastic Resin co-treated with Gemcitabine] results in decreased expression of BCL2 protein; [Theophylline co-treated with Gemcitabine] results in decreased expression of BCL2 protein; Gemcitabine inhibits the reaction [Fluorouracil results in decreased expression of BCL2 mRNA]; Gemcitabine inhibits the reaction [Fluorouracil results in decreased expression of BCL2 protein]; U 0126 inhibits the reaction [Gemcitabine results in decreased expression of BCL2 protein]
[Curcumin co-treated with Gemcitabine] results in decreased expression of BCL2 protein 		CTD PMID:15476743 PMID:15645133 PMID:15770523 PMID:16929163 PMID:17440100 More... NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
decreases expression 		ISO Gemcitabine inhibits the reaction [Fluorouracil affects the expression of BCL2L1 mRNA]; Gemcitabine inhibits the reaction [Fluorouracil affects the expression of BCL2L1 protein]
[Curcumin co-treated with Gemcitabine] results in decreased expression of BCL2L1 protein
Gemcitabine results in decreased expression of BCL2L1 protein 		CTD PMID:15476743 PMID:16929163 PMID:17440100 PMID:38122923 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907 		JBrowse link
G Bcl2l11 Bcl2-like 11 increases expression ISO Gemcitabine results in increased expression of BCL2L11 mRNA CTD PMID:17039268 NCBI chr 3:135,820,042...135,857,330
Ensembl chr 3:135,817,562...135,960,695 		JBrowse link
G Bcl6 BCL6, transcription repressor increases expression ISO Gemcitabine results in increased expression of BCL6 mRNA CTD PMID:17039268 NCBI chr11:90,358,753...90,382,049
Ensembl chr11:90,358,753...90,382,047 		JBrowse link
G Bdnf brain-derived neurotrophic factor decreases expression ISO Gemcitabine results in decreased expression of BDNF protein CTD PMID:20531411 NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657 		JBrowse link
G Bid BH3 interacting domain death agonist increases cleavage ISO Gemcitabine results in increased cleavage of BID protein CTD PMID:14750167 NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:155,785,377...155,808,275 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 increases expression ISO Gemcitabine results in increased expression of BIRC2 mRNA CTD PMID:17039268 NCBI chr 8:13,253,697...13,273,672
Ensembl chr 8:13,253,706...13,271,911 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 multiple interactions
affects expression 		ISO [Curcumin co-treated with Gemcitabine] results in decreased expression of BIRC3 protein
Gemcitabine affects the expression of BIRC3 mRNA 		CTD PMID:17039268 PMID:17440100 NCBI chr 8:13,285,702...13,313,329
Ensembl chr 8:13,285,703...13,298,590 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
decreases expression 		ISO [Curcumin co-treated with Gemcitabine] results in decreased expression of BIRC5 protein
Gemcitabine inhibits the reaction [Fluorouracil results in decreased expression of BIRC5 mRNA]; Gemcitabine inhibits the reaction [Fluorouracil results in decreased expression of BIRC5 protein]
Gemcitabine results in decreased expression of BIRC5 protein 		CTD PMID:16929163 PMID:17440100 PMID:38000456 NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,572,080...103,582,155 		JBrowse link
G Bnip3l BCL2 interacting protein 3 like increases expression ISO Gemcitabine results in increased expression of BNIP3L mRNA CTD PMID:17039268 NCBI chr15:45,350,081...45,373,213
Ensembl chr15:45,334,537...45,373,282 		JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase decreases expression ISO Gemcitabine results in decreased expression of BRAF mRNA CTD PMID:20103597 NCBI chr 4:69,329,772...69,476,931
Ensembl chr 4:69,342,813...69,476,931 		JBrowse link
G Brca1 BRCA1, DNA repair associated decreases response to substance
increases expression 		ISO BRCA1 results in decreased susceptibility to Gemcitabine
Gemcitabine results in increased expression of BRCA1 mRNA 		CTD PMID:20103597 PMID:21771338 NCBI chr10:86,917,693...86,978,012
Ensembl chr10:86,917,693...86,977,763 		JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions
increases activity
increases expression 		ISO Gemcitabine results in increased cleavage of CASP3 protein
[2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Gemcitabine] affects the activity of CASP3 protein; [3-(4-methylphenylsulfonyl)-2-propenenitrile co-treated with Gemcitabine] affects the activity of CASP3 protein; [alvocidib co-treated with Gemcitabine] results in increased cleavage of CASP3 protein; [Calcitriol co-treated with Gemcitabine] results in increased expression of CASP3 protein; [Gemcitabine co-treated with TNFRSF10B] affects the activity of CASP3 protein; [Vorinostat co-treated with Gemcitabine] results in increased activity of CASP3 protein; Gemcitabine results in increased activity of and results in increased cleavage of CASP3 protein; Gemcitabine results in increased expression of and results in increased activity of CASP3 protein; licoricidin promotes the reaction [Gemcitabine results in increased activity of CASP3 protein]; licoricidin promotes the reaction [Gemcitabine results in increased expression of and results in increased activity of CASP3 protein]; PIF1 protein affects the reaction [Gemcitabine results in increased activity of and results in increased cleavage of CASP3 protein]; Quercetin promotes the reaction [Gemcitabine results in increased activity of CASP3 protein]; SMG1 protein inhibits the reaction [Gemcitabine results in increased activity of CASP3 protein]
[10-propargyl-10-deazaaminopterin co-treated with Gemcitabine] results in increased activity of CASP3 protein; [Curcumin co-treated with Gemcitabine] results in decreased expression of CASP3 protein
Gemcitabine results in increased expression of CASP3 protein modified form 		CTD PMID:12479703 PMID:15476743 PMID:15726400 PMID:15770523 PMID:16153448 More... NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp6 caspase 6 multiple interactions ISO [Calcitriol co-treated with Gemcitabine] results in increased expression of CASP6 protein CTD PMID:20699664 NCBI chr 2:221,140,287...221,152,727
Ensembl chr 2:221,140,256...221,152,726 		JBrowse link
G Casp8 caspase 8 increases cleavage
increases activity
multiple interactions 		ISO Gemcitabine results in increased cleavage of CASP8 protein
Gemcitabine results in increased activity of CASP8 protein
[Calcitriol co-treated with Gemcitabine] results in increased expression of CASP8 protein; [Gemcitabine co-treated with TNFRSF10B] affects the activity of CASP8 protein; [TNFSF10 co-treated with Gemcitabine] results in increased activity of CASP8 protein; Gemcitabine results in increased activity of and results in increased cleavage of CASP8 protein; SFN protein inhibits the reaction [Gemcitabine results in increased activity of and results in increased cleavage of CASP8 protein]; YAP1 protein affects the reaction [Gemcitabine results in increased activity of and results in increased cleavage of CASP8 protein] 		CTD PMID:12479703 PMID:14750167 PMID:17159604 PMID:17671697 PMID:18089714 More... NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases cleavage
increases activity 		ISO [Curcumin co-treated with Gemcitabine] results in decreased expression of CASP9 protein
[Calcitriol co-treated with Gemcitabine] results in increased expression of CASP9 protein; Quercetin promotes the reaction [Gemcitabine results in increased activity of CASP9 protein]; SMG1 protein inhibits the reaction [Gemcitabine results in increased activity of CASP9 protein]
Gemcitabine results in increased cleavage of CASP9 protein 		CTD PMID:12479703 PMID:15476743 PMID:15726400 PMID:17159604 PMID:17440100 More... Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO Gemcitabine results in decreased expression of CCL2 protein CTD PMID:20531411 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875 		JBrowse link
G Ccl20 C-C motif chemokine ligand 20 increases expression ISO Gemcitabine results in increased expression of CCL20 mRNA CTD PMID:17039268 NCBI chr 9:91,837,139...91,839,736
Ensembl chr 9:91,836,946...91,839,736 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression ISO Gemcitabine results in increased expression of CCL3 protein CTD PMID:20531411 NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,948,889...68,950,439 		JBrowse link
G Ccnb1 cyclin B1 decreases expression
increases expression 		ISO Gemcitabine results in decreased expression of CCNB1 mRNA
Gemcitabine results in increased expression of CCNB1 protein 		CTD PMID:11504793 PMID:20103597 NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression 		ISO [Curcumin co-treated with Gemcitabine] results in decreased expression of CCND1 protein
Celecoxib promotes the reaction [Gemcitabine results in decreased expression of CCND1 protein]
Gemcitabine results in decreased expression of CCND1 mRNA; Gemcitabine results in decreased expression of CCND1 protein 		CTD PMID:16060994 PMID:17039268 PMID:17440100 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810 		JBrowse link
G Ccng2 cyclin G2 increases expression ISO Gemcitabine results in increased expression of CCNG2 mRNA CTD PMID:17039268 NCBI chr14:15,088,694...15,097,190
Ensembl chr14:15,088,695...15,096,206 		JBrowse link
G Cd274 CD274 molecule multiple interactions ISO [Oleanolic Acid co-treated with Gemcitabine] inhibits the reaction [IL1B protein results in increased expression of CD274 mRNA]; [Oleanolic Acid co-treated with Gemcitabine] inhibits the reaction [IL1B protein results in increased expression of CD274 protein]; Gemcitabine inhibits the reaction [IL1B protein results in increased expression of CD274 mRNA]; Gemcitabine inhibits the reaction [IL1B protein results in increased expression of CD274 protein] CTD PMID:32894642 NCBI chr 1:236,526,215...236,549,956
Ensembl chr 1:236,496,463...236,549,951 		JBrowse link
G Cd40 CD40 molecule decreases expression ISO Gemcitabine results in decreased expression of CD40 mRNA; Gemcitabine results in decreased expression of CD40 protein CTD PMID:17039268 PMID:20531411 NCBI chr 3:174,209,113...174,224,592
Ensembl chr 3:174,209,719...174,224,847 		JBrowse link
G Cd40lg CD40 ligand decreases expression ISO Gemcitabine results in decreased expression of CD40LG protein CTD PMID:20531411 NCBI chr  X:140,164,341...140,176,057
Ensembl chr  X:140,164,302...140,176,475 		JBrowse link
G Cd44 CD44 molecule affects expression ISO Gemcitabine affects the expression of CD44 mRNA CTD PMID:35063459 NCBI chr 3:109,610,824...109,699,776
Ensembl chr 3:109,612,054...109,699,424 		JBrowse link
G Cda cytidine deaminase affects response to substance
multiple interactions 		ISO CDA protein affects the susceptibility to Gemcitabine
[Crizotinib results in decreased expression of CDA protein] which results in increased susceptibility to Gemcitabine; CDA protein affects the susceptibility to [Gemcitabine co-treated with Mitomycin]; CDA protein affects the susceptibility to [Gemcitabine co-treated with Oxaliplatin] 		CTD PMID:18728667 PMID:22973962 NCBI chr 5:155,839,929...155,866,541
Ensembl chr 5:155,839,929...155,866,541 		JBrowse link
G Cdc25c cell division cycle 25C multiple interactions ISO [Gemcitabine co-treated with ON 01910] results in decreased expression of CDC25C protein CTD PMID:20103597 NCBI chr18:26,608,483...26,630,292
Ensembl chr18:26,609,959...26,630,292 		JBrowse link
G Cdh1 cadherin 1 increases expression ISO Gemcitabine results in increased expression of CDH1 mRNA CTD PMID:17039268 NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions 		ISO Gemcitabine results in increased expression of CDKN1A mRNA; Gemcitabine results in increased expression of CDKN1A protein
[alvocidib co-treated with Gemcitabine] results in increased expression of CDKN1A protein; [Gemcitabine results in decreased susceptibility to Gemcitabine] which results in increased expression of CDKN1A protein; Nicotine inhibits the reaction [Gemcitabine results in increased expression of CDKN1A protein] 		CTD PMID:15476743 PMID:15770523 PMID:16601104 PMID:17039268 PMID:25189999 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases response to substance ISO CDKN1B results in decreased susceptibility to Gemcitabine CTD PMID:21652059 NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases expression ISO Gemcitabine results in increased expression of CEBPB mRNA CTD PMID:17039268 NCBI chr 3:176,817,005...176,818,436
Ensembl chr 3:176,816,859...176,838,072 		JBrowse link
G Chrdl2 chordin-like 2 multiple interactions ISO [Gemcitabine co-treated with Erlotinib Hydrochloride] affects the expression of CHRDL2 protein CTD PMID:24979617 NCBI chr 1:154,343,201...154,370,651
Ensembl chr 1:163,755,316...163,782,757 		JBrowse link
G Ckb creatine kinase B decreases expression ISO Gemcitabine results in decreased expression of CKB mRNA CTD PMID:17039268 NCBI chr 6:136,550,583...136,553,464
Ensembl chr 6:136,549,844...136,553,478 		JBrowse link
G Clic4 chloride intracellular channel 4 increases expression ISO Gemcitabine results in increased expression of CLIC4 mRNA CTD PMID:17039268 NCBI chr 5:152,737,371...152,797,118
Ensembl chr 5:152,737,371...152,797,118 		JBrowse link
G Clu clusterin increases expression
affects response to substance 		ISO Gemcitabine results in increased expression of CLU protein
CLU protein affects the susceptibility to Gemcitabine 		CTD PMID:19007378 NCBI chr15:44,336,619...44,375,861
Ensembl chr15:44,359,914...44,375,860 		JBrowse link
G Cnr1 cannabinoid receptor 1 multiple interactions
increases expression 		ISO BAY 11-7085 inhibits the reaction [Gemcitabine results in increased expression of CNR1 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Gemcitabine results in increased expression of CNR1 mRNA]; Dactinomycin inhibits the reaction [Gemcitabine results in increased expression of CNR1 mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [Gemcitabine results in increased expression of CNR1 mRNA] CTD PMID:21525939 NCBI chr 5:53,204,867...53,230,396
Ensembl chr 5:53,204,260...53,239,252 		JBrowse link
G Cnr2 cannabinoid receptor 2 multiple interactions
increases expression 		ISO BAY 11-7085 inhibits the reaction [Gemcitabine results in increased expression of CNR2 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Gemcitabine results in increased expression of CNR2 mRNA]; Dactinomycin inhibits the reaction [Gemcitabine results in increased expression of CNR2 mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [Gemcitabine results in increased expression of CNR2 mRNA] CTD PMID:21525939 NCBI chr 5:153,408,968...153,435,092
Ensembl chr 5:153,409,147...153,435,961 		JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression
multiple interactions 		ISO Gemcitabine results in decreased expression of COL1A1 protein
Gemcitabine inhibits the reaction [Niclosamide results in decreased expression of COL1A1 protein]; Niclosamide inhibits the reaction [Gemcitabine results in decreased expression of COL1A1 protein] 		CTD PMID:35115509 NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460 		JBrowse link
G Crp C-reactive protein multiple interactions ISO [Gemcitabine co-treated with olsalazine] inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of CRP protein]; Gemcitabine inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of CRP protein] CTD PMID:38798245 NCBI chr13:87,694,062...87,695,978
Ensembl chr13:87,657,317...87,707,514 		JBrowse link
G Csf2 colony stimulating factor 2 decreases expression ISO Gemcitabine results in decreased expression of CSF2 protein CTD PMID:20531411 NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,887,692...38,890,031 		JBrowse link
G Csf3 colony stimulating factor 3 decreases expression ISO Gemcitabine results in decreased expression of CSF3 protein CTD PMID:20531411 NCBI chr10:84,157,485...84,159,860
Ensembl chr10:84,157,211...84,159,860 		JBrowse link
G Csrp2 cysteine and glycine-rich protein 2 increases expression ISO Gemcitabine results in increased expression of CSRP2 mRNA CTD PMID:17039268 NCBI chr 7:48,235,415...48,254,049
Ensembl chr 7:48,235,383...48,266,238 		JBrowse link
G Cthrc1 collagen triple helix repeat containing 1 increases expression ISO Gemcitabine results in increased expression of CTHRC1 mRNA CTD PMID:17039268 NCBI chr 7:72,007,372...72,017,654
Ensembl chr 7:72,007,372...72,017,654 		JBrowse link
G Ctnnb1 catenin beta 1 increases expression
decreases expression 		ISO Gemcitabine results in increased expression of CTNNB1 mRNA
Gemcitabine results in decreased expression of CTNNB1 protein 		CTD PMID:25605917 PMID:38000456 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases expression ISO Gemcitabine results in increased expression of CXCL1 mRNA CTD PMID:17039268 NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,477,549...17,479,811 		JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 multiple interactions ISO [Gemcitabine co-treated with Erlotinib Hydrochloride] affects the expression of CXCL11 protein CTD PMID:24979617 NCBI chr14:15,973,728...15,976,503
Ensembl chr14:15,973,720...15,976,567 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression ISO Gemcitabine results in increased expression of CXCL2 mRNA CTD PMID:17039268 NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,465,242...17,467,255 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression ISO Gemcitabine results in increased expression of CXCL1 mRNA CTD PMID:17039268 NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,571,900...17,573,624 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 affects expression ISO Gemcitabine affects the expression of CXCR4 mRNA CTD PMID:20103597 NCBI chr13:42,630,383...42,634,288
Ensembl chr13:42,630,104...42,634,459 		JBrowse link
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 decreases expression ISO Gemcitabine results in decreased expression of CYP24A1 mRNA CTD PMID:17039268 NCBI chr 3:179,694,647...179,709,083
Ensembl chr 3:179,694,647...179,709,083 		JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 affects expression ISO Gemcitabine affects the expression of DDIT4 mRNA CTD PMID:17039268 NCBI chr20:28,434,938...28,437,037
Ensembl chr20:28,434,944...28,437,037 		JBrowse link
G Dhx9 DExH-box helicase 9 decreases expression ISO Gemcitabine results in decreased expression of DHX9 mRNA CTD PMID:17039268 NCBI chr13:68,152,813...68,189,580
Ensembl chr13:68,152,813...68,189,546 		JBrowse link
G Dlg2 discs large MAGUK scaffold protein 2 increases expression ISO Gemcitabine results in increased expression of DLG2 mRNA CTD PMID:17039268 NCBI chr 1:153,864,545...155,916,238
Ensembl chr 1:153,865,299...155,916,215 		JBrowse link
G Dnmt1 DNA methyltransferase 1 multiple interactions ISO [DNMT1 protein binds to SFN promoter] inhibits the reaction [Gemcitabine results in decreased susceptibility to Gemcitabine]; [Gemcitabine results in decreased susceptibility to Gemcitabine] inhibits the reaction [DNMT1 protein binds to SFN promoter]; [Gemcitabine results in decreased susceptibility to Gemcitabine] which results in increased expression of DNMT1 protein; [UHRF1 protein promotes the reaction [DNMT1 protein binds to SFN promoter]] inhibits the reaction [Gemcitabine results in decreased susceptibility to Gemcitabine]; DNMT1 protein inhibits the reaction [Gemcitabine results in decreased susceptibility to Gemcitabine] CTD PMID:25189999 NCBI chr 8:27,716,797...27,763,405
Ensembl chr 8:27,716,797...27,763,119 		JBrowse link
G Dnmt3b DNA methyltransferase 3 beta multiple interactions ISO [Gemcitabine results in decreased susceptibility to Gemcitabine] which results in increased expression of DNMT3B protein CTD PMID:25189999 NCBI chr 3:162,590,777...162,629,313
Ensembl chr 3:162,604,037...162,629,313 		JBrowse link
G Dpyd dihydropyrimidine dehydrogenase multiple interactions ISO [TYMP protein co-treated with DPYD protein] affects the susceptibility to Gemcitabine CTD PMID:18728667 NCBI chr 2:209,293,902...210,159,777
Ensembl chr 2:209,293,929...210,159,778 		JBrowse link
G Dync1h1 dynein cytoplasmic 1 heavy chain 1 decreases expression ISO Gemcitabine results in decreased expression of DYNC1H1 mRNA CTD PMID:17039268 NCBI chr 6:135,436,375...135,502,117
Ensembl chr 6:135,430,750...135,502,116 		JBrowse link
G Edn1 endothelin 1 decreases expression ISO Gemcitabine results in decreased expression of EDN1 protein CTD PMID:20531411 NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,660,799...22,666,687 		JBrowse link
G Edn2 endothelin 2 decreases expression ISO Gemcitabine results in decreased expression of EDN2 mRNA CTD PMID:17039268 NCBI chr 5:139,036,576...139,042,074
Ensembl chr 5:139,036,492...139,043,070 		JBrowse link
G Egf epidermal growth factor multiple interactions
decreases expression 		ISO 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to Gemcitabine]]; EGF promotes the reaction [TGFB1 results in decreased susceptibility to Gemcitabine]; Erlotinib Hydrochloride inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to Gemcitabine]]; pyrazolanthrone inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to Gemcitabine]]; U 0126 inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to Gemcitabine]]
Gemcitabine results in decreased expression of EGF protein 		CTD PMID:20531411 PMID:21613822 NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:220,893,660...220,976,297 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
increases degradation
increases phosphorylation
increases expression
decreases expression 		ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Gemcitabine results in increased phosphorylation of and results in increased degradation of EGFR protein]; EGFR gene mutant form results in increased susceptibility to [Gemcitabine co-treated with Cisplatin co-treated with Erlotinib Hydrochloride]; Gefitinib inhibits the reaction [Gemcitabine results in increased phosphorylation of and results in increased degradation of EGFR protein]; Gemcitabine promotes the reaction [HER3 protein binds to EGFR protein]
Gemcitabine results in increased degradation of EGFR protein
Gemcitabine results in increased phosphorylation of EGFR protein
Gemcitabine results in increased expression of EGFR mRNA
Gemcitabine results in decreased expression of EGFR mRNA; Gemcitabine results in decreased expression of EGFR protein 		CTD PMID:17146438 PMID:20103597 PMID:20726858 PMID:21541241 NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358 		JBrowse link
G Egr1 early growth response 1 increases expression ISO Gemcitabine results in increased expression of EGR1 mRNA CTD PMID:17039268 NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,736,838...26,740,843 		JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 multiple interactions
increases phosphorylation 		ISO Gemcitabine promotes the reaction [HER3 protein binds to EGFR protein]
Gemcitabine results in increased phosphorylation of HER3 protein 		CTD PMID:20726858 NCBI chr 7:1,579,079...1,600,379
Ensembl chr 7:1,579,816...1,601,120 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Gemcitabine binds to and results in decreased activity of ESR1 protein CTD PMID:25752796 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354 		JBrowse link
G Etv1 ETS variant transcription factor 1 increases expression ISO Gemcitabine results in increased expression of ETV1 mRNA CTD PMID:17039268 NCBI chr 6:61,316,836...61,408,985
Ensembl chr 6:61,317,429...61,408,959 		JBrowse link
G Evi2b ecotropic viral integration site 2B decreases expression ISO Gemcitabine results in decreased expression of EVI2B mRNA CTD PMID:17039268 NCBI chr10:64,970,659...64,972,277
Ensembl chr10:64,964,719...64,979,417 		JBrowse link
G F7 coagulation factor VII decreases expression ISO Gemcitabine results in decreased expression of F7 protein CTD PMID:20531411 NCBI chr16:83,191,896...83,202,775
Ensembl chr16:83,191,914...83,202,738 		JBrowse link
G Fas Fas cell surface death receptor increases expression ISO Gemcitabine results in increased expression of FAS mRNA; Gemcitabine results in increased expression of FAS protein CTD PMID:11138460 PMID:17159604 NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104 		JBrowse link
G Fbxo25 F-box protein 25 increases expression ISO Gemcitabine results in increased expression of FBXO25 mRNA CTD PMID:17039268 NCBI chr16:75,666,062...75,701,770
Ensembl chr16:82,370,059...82,403,919 		JBrowse link
G Fgf2 fibroblast growth factor 2 increases expression
multiple interactions 		ISO Gemcitabine results in increased expression of FGF2 protein
[Gemcitabine co-treated with IFNA2 protein] results in increased expression of FGF2 protein 		CTD PMID:12738744 PMID:20531411 NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:122,164,454...122,224,493 		JBrowse link
G Fgg fibrinogen gamma chain affects expression ISO Gemcitabine affects the expression of FGG mRNA CTD PMID:17039268 NCBI chr 2:170,652,929...170,660,372
Ensembl chr 2:170,652,234...170,661,170 		JBrowse link
G Fosl2 FOS like 2, AP-1 transcription factor subunit decreases expression ISO Gemcitabine results in decreased expression of FOSL2 mRNA CTD PMID:17039268 NCBI chr 6:30,017,952...30,039,269
Ensembl chr 6:30,021,916...30,039,406 		JBrowse link
G Fxyd3 FXYD domain-containing ion transport regulator 3 increases expression ISO Gemcitabine results in increased expression of FXYD3 mRNA CTD PMID:17039268 NCBI chr 1:95,432,918...95,440,129
Ensembl chr 1:95,432,919...95,439,702 		JBrowse link
G Gal3st1 galactose-3-O-sulfotransferase 1 decreases expression ISO Gemcitabine results in decreased expression of GAL3ST1 mRNA CTD PMID:17039268 NCBI chr14:83,094,265...83,109,992
Ensembl chr14:83,094,385...83,109,978 		JBrowse link
G Gas1 growth arrest-specific 1 decreases expression ISO Gemcitabine results in decreased expression of GAS1 mRNA CTD PMID:17039268 NCBI chr17:4,487,716...4,490,701
Ensembl chr17:4,484,283...4,497,657 		JBrowse link
G Gask1b golgi associated kinase 1B decreases expression ISO Gemcitabine results in decreased expression of GASK1B mRNA CTD PMID:17039268 NCBI chr 2:167,345,738...167,410,606
Ensembl chr 2:167,345,809...167,410,603 		JBrowse link
G Gdf15 growth differentiation factor 15 multiple interactions ISO [Gemcitabine co-treated with Erlotinib Hydrochloride] affects the expression of GDF15 protein CTD PMID:24979617 NCBI chr16:18,838,436...18,842,022
Ensembl chr16:18,838,436...18,842,022 		JBrowse link
G Gipc1 GIPC PDZ domain containing family, member 1 affects response to substance ISO GIPC1 affects the susceptibility to Gemcitabine CTD PMID:25469510 NCBI chr19:41,380,125...41,392,078
Ensembl chr19:41,380,125...41,391,725 		JBrowse link
G Gli2 GLI family zinc finger 2 affects expression ISO Gemcitabine affects the expression of GLI2 mRNA CTD PMID:20103597 NCBI chr13:32,499,678...32,716,418
Ensembl chr13:32,499,678...32,716,418 		JBrowse link
G Glrx glutaredoxin increases expression ISO Gemcitabine results in increased expression of GLRX mRNA CTD PMID:17039268 NCBI chr 2:7,073,737...7,083,548
Ensembl chr 2:7,073,759...7,083,543 		JBrowse link
G Golph3 golgi phosphoprotein 3 increases response to substance ISO GOLPH3 protein results in increased susceptibility to Gemcitabine CTD PMID:38828452 NCBI chr 2:63,072,610...63,103,091
Ensembl chr 2:63,074,256...63,113,577 		JBrowse link
G Gpc3 glypican 3 increases expression ISO Gemcitabine results in increased expression of GPC3 mRNA CTD PMID:17039268 NCBI chr  X:136,789,770...137,157,598
Ensembl chr  X:136,789,770...137,157,639 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO [Gemcitabine co-treated with olsalazine] inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of GPT protein]; Gemcitabine inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of GPT protein] CTD PMID:38798245 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation ISO Gemcitabine results in increased phosphorylation of GSK3B protein CTD PMID:16570353 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249 		JBrowse link
G Gtf2a1 general transcription factor 2A subunit 1 affects expression ISO Gemcitabine affects the expression of GTF2A1 mRNA CTD PMID:17039268 NCBI chr 6:116,219,614...116,252,220
Ensembl chr 6:116,219,614...116,252,220 		JBrowse link
G H2ax H2A.X variant histone increases expression
multiple interactions 		ISO Gemcitabine results in increased expression of H2AX protein; Gemcitabine results in increased expression of H2AX protein modified form
PIF1 protein inhibits the reaction [Gemcitabine results in increased expression of H2AX protein]; Thymidine inhibits the reaction [PIF1 protein inhibits the reaction [Gemcitabine results in increased expression of H2AX protein]] 		CTD PMID:20798217 PMID:37183367 PMID:38000456 NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:53,568,281...53,573,079 		JBrowse link
G H4c14 H4 clustered histone 14 decreases expression ISO Gemcitabine results in decreased expression of H4C2 mRNA CTD PMID:17039268 NCBI chr 2:183,831,601...183,831,996
Ensembl chr 4:171,403,627...171,403,938
Ensembl chr17:171,403,627...171,403,938
Ensembl chr17:171,403,627...171,403,938
Ensembl chr17:171,403,627...171,403,938 		JBrowse link
G Hdac9 histone deacetylase 9 increases expression ISO Gemcitabine results in increased expression of HDAC9 mRNA CTD PMID:17039268 NCBI chr 6:56,489,472...57,351,654
Ensembl chr 6:56,490,988...57,351,835 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha affects response to substance ISO HIF1A protein affects the susceptibility to Gemcitabine CTD PMID:16628086 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions ISO Gemcitabine promotes the reaction [nuciferine results in decreased expression of HMGCR protein] CTD PMID:31627466 NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression 		ISO CASC9 protein affects the reaction [Gemcitabine results in increased expression of HMOX1 mRNA]; CASC9 protein affects the reaction [Gemcitabine results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [Gemcitabine results in increased expression of HMOX1 mRNA]
Gemcitabine results in increased expression of HMOX1 mRNA; Gemcitabine results in increased expression of HMOX1 protein 		CTD PMID:35913601 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Hoxb2 homeobox B2 increases expression ISO Gemcitabine results in increased expression of HOXB2 mRNA CTD PMID:17039268 NCBI chr10:81,814,340...81,816,731
Ensembl chr10:81,814,340...81,816,726 		JBrowse link
G Hspa1l heat shock protein family A (Hsp70) member 1 like decreases expression ISO Gemcitabine results in decreased expression of HSPA1L mRNA CTD PMID:17039268 NCBI chr20:3,853,496...3,860,223
Ensembl chr20:3,853,331...3,876,877 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO Gemcitabine results in increased expression of HSPA5 mRNA CTD PMID:17039268 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790 		JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression
multiple interactions 		ISO Gemcitabine results in decreased expression of ICAM1 protein
[Curcumin co-treated with Gemcitabine] results in decreased expression of ICAM1 protein 		CTD PMID:17440100 PMID:20531411 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617 		JBrowse link
G Ifng interferon gamma decreases expression ISO Gemcitabine results in decreased expression of IFNG protein CTD PMID:20531411 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor decreases expression ISO Gemcitabine results in decreased expression of IGF1R mRNA CTD PMID:20103597 NCBI chr 1:130,959,787...131,248,664
Ensembl chr 1:130,959,997...131,248,664 		JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 affects expression ISO Gemcitabine affects the expression of IGFBP3 mRNA CTD PMID:20103597 NCBI chr14:86,270,208...86,277,944
Ensembl chr14:86,270,208...86,277,944 		JBrowse link
G Il10 interleukin 10 decreases expression ISO Gemcitabine results in decreased expression of IL10 protein CTD PMID:20531411 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580 		JBrowse link
G Il13 interleukin 13 increases expression ISO Gemcitabine results in increased expression of IL13 protein CTD PMID:20531411 NCBI chr10:38,290,926...38,293,483
Ensembl chr10:38,290,926...38,293,483 		JBrowse link
G Il15 interleukin 15 decreases expression ISO Gemcitabine results in decreased expression of IL15 protein CTD PMID:20531411 NCBI chr19:42,536,160...42,611,349
Ensembl chr19:42,545,346...42,611,348 		JBrowse link
G Il16 interleukin 16 increases expression ISO Gemcitabine results in increased expression of IL16 protein CTD PMID:20531411 NCBI chr 1:147,026,852...147,127,177
Ensembl chr 1:147,027,097...147,127,023 		JBrowse link
G Il1a interleukin 1 alpha decreases expression ISO Gemcitabine results in decreased expression of IL1A protein CTD PMID:20531411 NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013 		JBrowse link
G Il1b interleukin 1 beta decreases expression
multiple interactions 		ISO Gemcitabine results in decreased expression of IL1B protein
[Oleanolic Acid co-treated with Gemcitabine] inhibits the reaction [IL1B protein results in increased expression of CD274 mRNA]; [Oleanolic Acid co-treated with Gemcitabine] inhibits the reaction [IL1B protein results in increased expression of CD274 protein]; Gemcitabine inhibits the reaction [IL1B protein results in increased expression of CD274 mRNA]; Gemcitabine inhibits the reaction [IL1B protein results in increased expression of CD274 protein] 		CTD PMID:20531411 PMID:32894642 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il4 interleukin 4 decreases expression ISO Gemcitabine results in decreased expression of IL4 protein CTD PMID:20531411 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549 		JBrowse link
G Il6 interleukin 6 increases secretion
decreases expression
increases expression 		ISO Gemcitabine results in increased secretion of IL6 protein
Gemcitabine results in decreased expression of IL6 protein
Gemcitabine results in increased expression of IL6 mRNA 		CTD PMID:17039268 PMID:20531411 PMID:28007550 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Ilk integrin-linked kinase affects response to substance ISO ILK protein affects the susceptibility to Gemcitabine CTD PMID:15867245 NCBI chr 1:169,500,716...169,506,972
Ensembl chr 1:169,498,681...169,506,964 		JBrowse link
G Ins2 insulin 2 increases expression ISO Gemcitabine results in increased expression of INS protein CTD PMID:20531411 NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:207,272,742...207,273,805 		JBrowse link
G Insig1 insulin induced gene 1 increases expression ISO Gemcitabine results in increased expression of INSIG1 mRNA CTD PMID:17039268 NCBI chr 4:8,049,339...8,057,812
Ensembl chr 4:8,049,556...8,057,778 		JBrowse link
G Iqgap1 IQ motif containing GTPase activating protein 1 increases expression ISO Gemcitabine results in increased expression of IQGAP1 mRNA CTD PMID:17039268 NCBI chr 1:144,088,788...144,178,989
Ensembl chr 1:144,088,793...144,179,043 		JBrowse link
G Irak2 interleukin-1 receptor-associated kinase 2 increases expression ISO Gemcitabine results in increased expression of IRAK2 mRNA CTD PMID:17039268 NCBI chr 4:148,341,704...148,398,211
Ensembl chr 4:148,341,719...148,398,210 		JBrowse link
G Irf3 interferon regulatory factor 3 decreases expression ISO Gemcitabine results in decreased expression of IRF3 mRNA CTD PMID:17039268 NCBI chr 1:104,616,608...104,621,402
Ensembl chr 1:104,616,469...104,621,401 		JBrowse link
G Itgav integrin subunit alpha V multiple interactions ISO [ITGB6 co-treated with ITGAV] affects the susceptibility to Gemcitabine CTD PMID:20150628 NCBI chr 3:89,245,382...89,333,512
Ensembl chr 3:89,245,095...89,333,511 		JBrowse link
G Itgb6 integrin subunit beta 6 multiple interactions ISO [ITGB6 co-treated with ITGAV] affects the susceptibility to Gemcitabine CTD PMID:20150628 NCBI chr 3:65,454,964...65,579,179
Ensembl chr 3:65,456,713...65,530,333 		JBrowse link
G Itsn2 intersectin 2 increases expression ISO Gemcitabine results in increased expression of ITSN2 mRNA CTD PMID:17039268 NCBI chr 6:33,336,086...33,446,818
Ensembl chr 6:33,336,441...33,446,818 		JBrowse link
G Jam3 junctional adhesion molecule 3 decreases expression ISO Gemcitabine results in decreased expression of JAM3 mRNA CTD PMID:17039268 NCBI chr 8:33,767,606...33,828,451
Ensembl chr 8:33,767,607...33,828,623 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [Copper co-treated with Disulfiram co-treated with Gemcitabine] results in increased expression of and results in increased phosphorylation of JUN protein CTD PMID:23033007 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285 		JBrowse link
G Kctd12 potassium channel tetramerization domain containing 12 decreases expression ISO Gemcitabine results in decreased expression of KCTD12 mRNA CTD PMID:17039268 NCBI chr15:86,214,786...86,220,725
Ensembl chr15:86,214,840...86,224,539 		JBrowse link
G Kitlg KIT ligand multiple interactions
decreases expression 		ISO [Gemcitabine co-treated with Erlotinib Hydrochloride] affects the expression of KITLG protein
Gemcitabine results in decreased expression of KITLG protein 		CTD PMID:20531411 PMID:24979617 NCBI chr 7:36,782,621...36,863,796
Ensembl chr 7:36,782,638...36,863,793 		JBrowse link
G Klf8 KLF transcription factor 8 increases expression ISO Gemcitabine results in increased expression of KLF8 mRNA CTD PMID:17039268 NCBI chr  X:21,329,081...21,508,720 JBrowse link
G Krt8 keratin 8 decreases expression ISO Gemcitabine results in decreased expression of KRT8 mRNA CTD PMID:17039268 NCBI chr 7:135,002,886...135,010,339
Ensembl chr 7:135,002,894...135,010,403 		JBrowse link
G Larp4b La ribonucleoprotein 4B increases expression ISO Gemcitabine results in increased expression of LARP4B mRNA CTD PMID:17039268 NCBI chr17:65,813,125...65,908,920
Ensembl chr17:65,830,022...65,908,676 		JBrowse link
G Lep leptin decreases expression ISO Gemcitabine results in decreased expression of LEP protein CTD PMID:20531411 NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:58,626,523...58,640,661 		JBrowse link
G Lifr LIF receptor subunit alpha increases expression ISO Gemcitabine results in increased expression of LIFR mRNA CTD PMID:17039268 NCBI chr 2:57,951,787...58,020,357
Ensembl chr 2:57,952,975...58,020,364 		JBrowse link
G Lpar6 lysophosphatidic acid receptor 6 decreases expression ISO Gemcitabine results in decreased expression of LPAR6 mRNA CTD PMID:17039268 NCBI chr15:54,826,110...54,827,919
Ensembl chr15:54,823,717...54,978,783 		JBrowse link
G Lrrc28 leucine rich repeat containing 28 increases expression ISO Gemcitabine results in increased expression of LRRC28 mRNA CTD PMID:17039268 NCBI chr 1:130,526,757...130,655,991
Ensembl chr 1:130,537,930...130,655,949 		JBrowse link
G Lta lymphotoxin alpha increases expression ISO Gemcitabine results in increased expression of LTA protein CTD PMID:20531411 NCBI chr20:3,622,291...3,625,852
Ensembl chr20:3,623,527...3,625,533 		JBrowse link
G Lyz2 lysozyme 2 decreases expression ISO Gemcitabine results in decreased expression of LYZ mRNA CTD PMID:17039268 NCBI chr 7:54,792,715...54,798,060
Ensembl chr 7:54,792,716...54,798,011 		JBrowse link
G Maf MAF bZIP transcription factor increases expression ISO Gemcitabine results in increased expression of MAF mRNA CTD PMID:17039268 NCBI chr19:60,259,200...60,622,145
Ensembl chr19:60,269,541...60,621,378 		JBrowse link
G Magea10 MAGE family member A10 decreases expression ISO Gemcitabine results in decreased expression of MAGEA10 mRNA CTD PMID:17039268 NCBI chr  X:150,212,708...150,217,954
Ensembl chr  X:155,255,035...155,260,281 		JBrowse link
G Magi1 membrane associated guanylate kinase, WW and PDZ domain containing 1 increases expression ISO Gemcitabine results in increased expression of MAGI1 mRNA CTD PMID:17039268 NCBI chr 4:127,762,590...128,368,228
Ensembl chr 4:127,762,590...128,367,833 		JBrowse link
G Map2k3 mitogen activated protein kinase kinase 3 increases phosphorylation ISO Gemcitabine results in increased phosphorylation of MAP2K3 protein CTD PMID:15003513 NCBI chr10:46,107,639...46,128,986
Ensembl chr10:46,106,548...46,129,004 		JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 increases phosphorylation ISO Gemcitabine results in increased phosphorylation of MAP2K6 protein CTD PMID:15003513 NCBI chr10:95,872,747...95,987,747
Ensembl chr10:95,872,546...95,987,721 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions 		ISO Gemcitabine results in increased phosphorylation of MAPK1 protein
[Copper co-treated with Disulfiram co-treated with Gemcitabine] results in increased phosphorylation of MAPK1 protein 		CTD PMID:15476743 PMID:23033007 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions 		ISO Gemcitabine results in increased phosphorylation of MAPK3 protein
[Copper co-treated with Disulfiram co-treated with Gemcitabine] results in increased phosphorylation of MAPK3 protein 		CTD PMID:15476743 PMID:23033007 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Marcks myristoylated alanine rich protein kinase C substrate increases expression
increases phosphorylation 		ISO Gemcitabine results in increased expression of MARCKS mRNA
Gemcitabine results in increased phosphorylation of MARCKS protein 		CTD PMID:9523737 PMID:17039268 NCBI chr20:42,240,185...42,245,882
Ensembl chr20:42,240,185...42,245,882 		JBrowse link
G Mars1 methionyl-tRNA synthetase 1 increases expression ISO Gemcitabine results in increased expression of MARS1 mRNA CTD PMID:17039268 NCBI chr 7:65,006,456...65,023,880
Ensembl chr 7:64,998,544...65,023,753 		JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression
decreases expression 		ISO Gemcitabine results in increased expression of MDM2 mRNA
Gemcitabine results in decreased expression of MDM2 mRNA 		CTD PMID:17039268 PMID:20103597 NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:55,176,560...55,200,791 		JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase decreases expression ISO Gemcitabine results in decreased expression of MGMT mRNA CTD PMID:17039268 NCBI chr 1:201,140,832...201,367,481
Ensembl chr 1:201,140,661...201,367,482 		JBrowse link
G Mir222 microRNA 222 affects response to substance ISO MIR222 mRNA affects the susceptibility to Gemcitabine CTD PMID:35974258 NCBI chr  X:6,022,621...6,022,723
Ensembl chr  X:6,022,621...6,022,723 		JBrowse link
G Mir24-2 microRNA 24-2 multiple interactions ISO MIR24-2 mRNA affects the susceptibility to [Betulinic Acid co-treated with Gemcitabine] CTD PMID:25841339 NCBI chr19:40,859,455...40,859,562 JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions
decreases expression 		ISO [Curcumin co-treated with Gemcitabine] results in decreased expression of MKI67 protein
Gemcitabine results in decreased expression of MKI67 protein 		CTD PMID:17440100 PMID:38000456 NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:199,926,150...199,952,593 		JBrowse link
G Mmp3 matrix metallopeptidase 3 decreases expression ISO Gemcitabine results in decreased expression of MMP3 protein CTD PMID:20531411 NCBI chr 8:12,925,267...12,938,828
Ensembl chr 8:12,925,280...12,938,826 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO [Gemcitabine co-treated with IFNA2 protein] results in increased expression of MMP9 protein
[Curcumin co-treated with Gemcitabine] results in decreased expression of MMP9 protein 		CTD PMID:12738744 PMID:17440100 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442 		JBrowse link
G Mpo myeloperoxidase increases expression ISO Gemcitabine results in increased expression of MPO protein CTD PMID:20531411 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056 		JBrowse link
G Msh6 mutS homolog 6 affects response to substance ISO MSH6 protein affects the susceptibility to Gemcitabine CTD PMID:39168426 NCBI chr 6:12,316,190...12,333,505
Ensembl chr 6:12,316,198...12,333,844 		JBrowse link
G Msln mesothelin multiple interactions EXP Gemcitabine results in decreased expression of and results in decreased secretion of MSLN protein alternative form CTD PMID:25347530 NCBI chr10:15,276,489...15,285,921
Ensembl chr10:15,275,659...15,282,153 		JBrowse link
G Mt-co3 mitochondrially encoded cytochrome c oxidase III multiple interactions
decreases response to substance 		ISO Sodium Azide inhibits the reaction [COX3 protein results in decreased susceptibility to Gemcitabine] CTD PMID:17428446 NCBI chr MT:8,599...9,382
Ensembl chr MT:8,584...9,367 		JBrowse link
G Mxi1 MAX interactor 1, dimerization protein increases expression ISO Gemcitabine results in increased expression of MXI1 mRNA CTD PMID:17039268 NCBI chr 1:262,329,274...262,389,037
Ensembl chr 1:262,328,875...262,389,036 		JBrowse link
G Myb MYB proto-oncogene, transcription factor increases expression ISO Gemcitabine results in increased expression of MYB mRNA CTD PMID:17039268 NCBI chr 1:17,759,309...17,793,306
Ensembl chr 1:17,759,309...17,792,547 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
affects response to substance 		ISO [Oligonucleotides binds to MYC gene] which results in increased susceptibility to Gemcitabine
MYC affects the susceptibility to Gemcitabine
[Curcumin co-treated with Gemcitabine] results in decreased expression of MYC protein 		CTD PMID:17440100 PMID:23681918 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028 		JBrowse link
G Nanog Nanog homeobox decreases expression ISO Gemcitabine results in decreased expression of NANOG mRNA CTD PMID:25605917 PMID:35063459 NCBI chr 4:157,615,687...157,623,061
Ensembl chr 4:157,615,687...157,623,061 		JBrowse link
G Ncbp1 nuclear cap binding protein subunit 1 increases expression ISO Gemcitabine results in increased expression of NCBP1 mRNA CTD PMID:17039268 NCBI chr 5:65,211,632...65,244,532
Ensembl chr 5:65,211,358...65,244,665 		JBrowse link
G Nedd9 neural precursor cell expressed, developmentally down-regulated 9 increases expression ISO Gemcitabine results in increased expression of NEDD9 mRNA CTD PMID:17039268 NCBI chr17:23,495,531...23,673,780
Ensembl chr17:23,495,492...23,675,668 		JBrowse link
G Neu1 neuraminidase 1 increases expression ISO Gemcitabine results in increased expression of NEU1 mRNA CTD PMID:17039268 NCBI chr20:3,902,120...3,906,383
Ensembl chr20:3,902,120...3,906,383 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 decreases response to substance
multiple interactions
increases expression 		ISO NFE2L2 protein results in decreased susceptibility to Gemcitabine
CASC9 protein affects the reaction [Gemcitabine results in increased expression of NFE2L2 mRNA]; CASC9 protein affects the reaction [Gemcitabine results in increased expression of NFE2L2 protein]; NFE2L2 protein affects the reaction [Gemcitabine results in increased expression of CASC9 mRNA]; NFE2L2 protein affects the reaction [Gemcitabine results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [Gemcitabine results in increased expression of NQO1 mRNA]
Gemcitabine results in increased expression of NFE2L2 mRNA; Gemcitabine results in increased expression of NFE2L2 protein 		CTD PMID:21489257 PMID:35913601 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Nfkb2 nuclear factor kappa B subunit 2 affects expression ISO Gemcitabine affects the expression of NFKB2 mRNA CTD PMID:17039268 NCBI chr 1:255,106,010...255,114,649
Ensembl chr 1:255,107,374...255,114,637 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO [Mastic Resin co-treated with Gemcitabine] results in increased expression of NFKBIA protein CTD PMID:20523344 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G Nfkbie NFKB inhibitor epsilon affects expression ISO Gemcitabine affects the expression of NFKBIE mRNA CTD PMID:17039268 NCBI chr 9:22,941,037...22,947,872
Ensembl chr 9:22,941,040...22,947,872 		JBrowse link
G Nnmt nicotinamide N-methyltransferase increases expression ISO Gemcitabine results in increased expression of NNMT mRNA CTD PMID:17039268 NCBI chr 8:57,820,156...57,851,301
Ensembl chr 8:57,825,464...57,843,174 		JBrowse link
G Notch1 notch receptor 1 multiple interactions
increases expression 		ISO sulforaphane inhibits the reaction [Gemcitabine results in increased expression of NOTCH1 protein] CTD PMID:20940707 NCBI chr 3:29,676,040...29,721,613
Ensembl chr 3:29,676,171...29,721,613 		JBrowse link
G Npepps aminopeptidase puromycin sensitive decreases expression ISO Gemcitabine results in decreased expression of NPEPPS mRNA CTD PMID:17039268 NCBI chr10:82,687,869...82,770,363
Ensembl chr10:82,687,871...82,770,363 		JBrowse link
G Npm1 nucleophosmin 1 decreases response to substance ISO NPM1 protein results in decreased susceptibility to Gemcitabine CTD PMID:24736981 NCBI chr10:18,245,739...18,255,913
Ensembl chr10:18,245,740...18,256,024
Ensembl chr  X:18,245,740...18,256,024 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression 		ISO CASC9 protein affects the reaction [Gemcitabine results in increased expression of NQO1 mRNA]; CASC9 protein affects the reaction [Gemcitabine results in increased expression of NQO1 protein]; NFE2L2 protein affects the reaction [Gemcitabine results in increased expression of NQO1 mRNA]
Gemcitabine results in increased expression of NQO1 mRNA; Gemcitabine results in increased expression of NQO1 protein 		CTD PMID:35913601 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260 		JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 increases expression ISO Gemcitabine results in increased expression of NR4A3 mRNA CTD PMID:17039268 NCBI chr 5:67,157,141...67,198,287
Ensembl chr 5:67,157,375...67,198,285 		JBrowse link
G Nrg1 neuregulin 1 increases expression ISO Gemcitabine results in increased expression of NRG1 mRNA CTD PMID:17039268 NCBI chr16:65,954,084...67,007,484
Ensembl chr16:65,953,865...66,999,849 		JBrowse link
G Nrp1 neuropilin 1 decreases response to substance ISO NRP1 protein results in decreased susceptibility to Gemcitabine CTD PMID:15956974 NCBI chr19:73,256,557...73,411,705
Ensembl chr19:73,256,557...73,411,702 		JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator decreases expression
affects response to substance 		ISO Gemcitabine results in decreased expression of NUPR1 mRNA
NUPR1 affects the susceptibility to Gemcitabine 		CTD PMID:16397047 NCBI chr 1:190,643,866...190,645,901
Ensembl chr 1:190,643,867...190,645,901 		JBrowse link
G Or4d6 olfactory receptor family 4 subfamily D member 6 affects response to substance ISO OR4D6 gene SNP affects the susceptibility to Gemcitabine CTD PMID:26378035 NCBI chr 1:218,463,801...218,464,745
Ensembl chr 1:218,463,801...218,464,745 		JBrowse link
G Osm oncostatin M multiple interactions ISO [Gemcitabine co-treated with Erlotinib Hydrochloride] affects the expression of OSM protein CTD PMID:24979617 NCBI chr14:83,327,202...83,332,073
Ensembl chr14:83,327,554...83,331,827 		JBrowse link
G Pappa pappalysin decreases expression ISO Gemcitabine results in decreased expression of PAPPA protein CTD PMID:20531411 NCBI chr 5:83,513,358...83,751,364
Ensembl chr 5:83,513,358...83,751,361 		JBrowse link
G Paqr8 progestin and adipoQ receptor family member 8 increases expression ISO Gemcitabine results in increased expression of PAQR8 mRNA CTD PMID:17039268 NCBI chr 9:23,312,521...23,362,175
Ensembl chr 9:30,808,923...30,861,043 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions 		ISO Gemcitabine results in increased cleavage of PARP1 protein
[alvocidib co-treated with Gemcitabine] results in increased cleavage of PARP1 protein; benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [Gemcitabine results in increased cleavage of PARP1 protein]; SFN protein inhibits the reaction [Gemcitabine results in increased cleavage of PARP1 protein]; YAP1 protein affects the reaction [Gemcitabine results in increased cleavage of PARP1 protein] 		CTD PMID:15770523 PMID:17146438 PMID:26894857 PMID:38122923 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567 		JBrowse link
G Parp2 poly (ADP-ribose) polymerase 2 decreases response to substance ISO PARP2 protein results in decreased susceptibility to Gemcitabine CTD PMID:20798217 NCBI chr15:26,494,722...26,517,893
Ensembl chr15:26,494,731...26,517,891 		JBrowse link
G Pcsk9 proprotein convertase subtilisin/kexin type 9 increases expression ISO Gemcitabine results in increased expression of PCSK9 mRNA CTD PMID:17039268 NCBI chr 5:126,440,102...126,462,507
Ensembl chr 5:126,440,102...126,462,507 		JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 decreases response to substance ISO PDPK1 protein modified form results in decreased susceptibility to Gemcitabine CTD PMID:16782806 NCBI chr10:13,610,000...13,687,226
Ensembl chr10:13,610,063...13,679,181 		JBrowse link
G Pdzk1ip1 PDZK1 interacting protein 1 increases expression ISO Gemcitabine results in increased expression of PDZK1IP1 mRNA CTD PMID:17039268 NCBI chr 5:128,618,050...128,623,131
Ensembl chr 5:133,841,313...133,859,893 		JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 multiple interactions ISO Gemcitabine promotes the reaction [Curcumin results in decreased expression of PECAM1 protein] CTD PMID:17440100 NCBI chr10:92,090,263...92,152,002
Ensembl chr10:92,090,235...92,151,839 		JBrowse link
G Pgr progesterone receptor multiple interactions ISO Gemcitabine binds to and results in decreased activity of PGR protein CTD PMID:25752796 NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:14,354,398...14,413,271 		JBrowse link
G Pif1 PIF1 5'-to-3' DNA helicase decreases response to substance
multiple interactions
affects response to substance 		ISO PIF1 protein results in decreased susceptibility to Gemcitabine
PIF1 protein affects the reaction [Gemcitabine results in increased activity of and results in increased cleavage of CASP3 protein]; PIF1 protein inhibits the reaction [Gemcitabine results in increased expression of H2AX protein]; Thymidine inhibits the reaction [PIF1 protein inhibits the reaction [Gemcitabine results in increased expression of H2AX protein]]
PIF1 protein affects the susceptibility to Gemcitabine 		CTD PMID:37183367 NCBI chr 8:75,005,820...75,015,331
Ensembl chr 8:75,006,815...75,015,331 		JBrowse link
G Pja2 praja ring finger ubiquitin ligase 2 increases expression ISO Gemcitabine results in increased expression of PJA2 mRNA CTD PMID:17039268 NCBI chr 9:111,403,624...111,453,703
Ensembl chr 9:111,403,624...111,453,703 		JBrowse link
G Pkm pyruvate kinase M1/2 affects response to substance ISO PKM protein alternative form affects the susceptibility to Gemcitabine CTD PMID:38000456 NCBI chr 8:68,949,731...68,975,394
Ensembl chr 8:68,948,815...68,975,396 		JBrowse link
G Plau plasminogen activator, urokinase increases expression ISO Gemcitabine results in increased expression of PLAU mRNA CTD PMID:17039268 NCBI chr15:3,505,485...3,511,987
Ensembl chr15:3,505,487...3,512,030 		JBrowse link
G Plk1 polo-like kinase 1 decreases expression
affects response to substance
multiple interactions 		ISO Gemcitabine results in decreased expression of PLK1; Gemcitabine results in decreased expression of PLK1 mRNA
PLK1 protein affects the susceptibility to Gemcitabine
[Gemcitabine results in decreased expression of PLK1] which results in increased susceptibility to Gemcitabine; ON 01910 promotes the reaction [PLK1 protein affects the susceptibility to Gemcitabine] 		CTD PMID:20103597 NCBI chr 1:186,147,658...186,157,637
Ensembl chr 1:186,147,658...186,157,637 		JBrowse link
G Pou5f1 POU class 5 homeobox 1 decreases expression ISO Gemcitabine results in decreased expression of POU5F1 mRNA CTD PMID:35063459 NCBI chr20:3,227,836...3,232,598
Ensembl chr20:3,227,837...3,232,598 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha affects expression ISO Gemcitabine affects the expression of PPARA mRNA CTD PMID:19427843 NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714 		JBrowse link
G Ppard peroxisome proliferator-activated receptor delta affects expression ISO Gemcitabine affects the expression of PPARD mRNA CTD PMID:19427843 NCBI chr20:6,300,527...6,365,707
Ensembl chr20:6,352,183...6,365,707 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma affects expression ISO Gemcitabine affects the expression of PPARG mRNA CTD PMID:19427843 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104 		JBrowse link
G Ppfia4 PTPRF interacting protein alpha 4 increases expression ISO Gemcitabine results in increased expression of PPFIA4 mRNA CTD PMID:17039268 NCBI chr13:48,305,844...48,354,329
Ensembl chr13:48,305,848...48,354,279 		JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A increases expression ISO Gemcitabine results in increased expression of PPP1R15A mRNA CTD PMID:17039268 NCBI chr 1:105,136,521...105,139,596
Ensembl chr 1:105,136,525...105,139,774 		JBrowse link
G Psat1 phosphoserine aminotransferase 1 increases expression ISO Gemcitabine results in increased expression of PSAT1 mRNA CTD PMID:17039268 NCBI chr 1:222,623,553...222,646,187
Ensembl chr 1:222,623,556...222,655,693 		JBrowse link
G Ptch1 patched 1 affects expression ISO Gemcitabine affects the expression of PTCH1 mRNA CTD PMID:20103597 NCBI chr17:1,548,449...1,613,461
Ensembl chr17:1,548,449...1,613,461 		JBrowse link
G Pten phosphatase and tensin homolog affects expression ISO Gemcitabine affects the expression of PTEN mRNA CTD PMID:17039268 NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:240,043,707...240,110,330 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases expression ISO Gemcitabine results in decreased expression of PTGS1 mRNA CTD PMID:17039268 NCBI chr 3:39,981,419...40,002,993
Ensembl chr 3:39,981,415...40,002,990 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [Curcumin co-treated with Gemcitabine] results in decreased expression of PTGS2 protein CTD PMID:17440100 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Ptk2 protein tyrosine kinase 2 decreases response to substance ISO PTK2 protein results in decreased susceptibility to Gemcitabine CTD PMID:14623342 NCBI chr 7:107,015,730...107,220,865
Ensembl chr 7:107,015,733...107,172,091 		JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 affects expression ISO Gemcitabine affects the expression of PTPN11 mRNA CTD PMID:17039268 NCBI chr12:41,026,079...41,085,577
Ensembl chr12:41,043,785...41,085,577 		JBrowse link
G Rab8a RAB8A, member RAS oncogene family decreases expression ISO Gemcitabine results in decreased expression of RAB8A mRNA CTD PMID:17039268 NCBI chr16:17,688,049...17,709,412
Ensembl chr16:17,688,050...17,709,477 		JBrowse link
G Rbm17 RNA binding motif protein 17 decreases response to substance ISO RBM17 protein results in decreased susceptibility to Gemcitabine CTD PMID:16061639 NCBI chr17:71,846,941...71,863,834
Ensembl chr17:71,846,916...71,864,431 		JBrowse link
G Reg3b regenerating family member 3 beta decreases expression ISO Gemcitabine results in decreased expression of REG3A mRNA CTD PMID:16570353 NCBI chr 4:112,419,776...112,423,014
Ensembl chr 4:112,419,776...112,423,014 		JBrowse link
G Rel REL proto-oncogene, NF-kB subunit multiple interactions
decreases expression 		ISO sulforaphane promotes the reaction [Gemcitabine results in decreased expression of REL protein] CTD PMID:20940707 NCBI chr14:101,891,238...101,922,324
Ensembl chr14:101,891,243...101,921,938 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases phosphorylation
multiple interactions
increases expression 		ISO Gemcitabine results in increased phosphorylation of RELA protein
[Gemcitabine co-treated with Doxorubicin co-treated with Paclitaxel] affects the localization of RELA protein; [Gemcitabine co-treated with Doxorubicin co-treated with Paclitaxel] results in increased expression of RELA protein; licoricidin inhibits the reaction [Gemcitabine results in increased phosphorylation of RELA protein]; Mastic Resin inhibits the reaction [Gemcitabine results in increased expression of RELA protein]
[Curcumin co-treated with Gemcitabine] results in decreased expression of RELA protein 		CTD PMID:17039268 PMID:17440100 PMID:20523344 PMID:29782821 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Rgs2 regulator of G-protein signaling 2 increases expression ISO Gemcitabine results in increased expression of RGS2 mRNA CTD PMID:17039268 NCBI chr13:58,350,063...58,352,666
Ensembl chr13:58,349,163...58,352,697 		JBrowse link
G Rnf149 ring finger protein 149 increases expression ISO Gemcitabine results in increased expression of RNF149 mRNA CTD PMID:17039268 NCBI chr 9:49,322,524...49,350,361
Ensembl chr 9:49,323,857...49,350,042 		JBrowse link
G Rpl37 ribosomal protein L37 increases expression ISO Gemcitabine results in increased expression of RPL37 mRNA CTD PMID:17039268 NCBI chr 2:55,942,827...55,944,905
Ensembl chr 2:55,942,945...55,944,900 		JBrowse link
G Rragd Ras-related GTP binding D increases expression ISO Gemcitabine results in increased expression of RRAGD mRNA CTD PMID:17039268 NCBI chr 5:52,170,234...52,205,700
Ensembl chr 5:52,169,783...52,209,000 		JBrowse link
G Rrm1 ribonucleotide reductase catalytic subunit M1 affects response to substance
multiple interactions 		ISO RRM1 protein affects the susceptibility to Gemcitabine
[Gemcitabine results in decreased susceptibility to Gemcitabine] which results in increased expression of RRM1 mRNA; [Gemcitabine results in decreased susceptibility to Gemcitabine] which results in increased expression of RRM1 protein 		CTD PMID:25189999 PMID:26894857 NCBI chr 1:166,235,904...166,260,206
Ensembl chr 1:166,235,900...166,260,944 		JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 multiple interactions
affects response to substance 		ISO [Gemcitabine results in decreased susceptibility to Gemcitabine] which results in increased expression of RRM2 protein
RRM2 protein affects the susceptibility to Gemcitabine 		CTD PMID:25189999 PMID:26894857 NCBI chr 6:47,044,755...47,075,370
Ensembl chr 6:47,067,690...47,075,370 		JBrowse link
G Rsl24d1 ribosomal L24 domain containing 1 increases expression ISO Gemcitabine results in increased expression of RSL24D1 mRNA CTD PMID:17039268 NCBI chr 8:82,733,627...82,742,632
Ensembl chr 8:82,733,649...82,744,497 		JBrowse link
G Sat1 spermidine/spermine N1-acetyl transferase 1 increases expression ISO Gemcitabine results in increased expression of SAT1 mRNA CTD PMID:17039268 NCBI chr  X:44,008,089...44,011,376
Ensembl chr  X:44,006,781...44,011,374 		JBrowse link
G Scd stearoyl-CoA desaturase increases expression ISO Gemcitabine results in increased expression of SCD mRNA CTD PMID:17039268 NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:253,218,970...253,231,785 		JBrowse link
G Sfn stratifin affects response to substance
decreases response to substance
increases methylation
multiple interactions 		ISO SFN protein affects the susceptibility to Gemcitabine
SFN protein results in decreased susceptibility to Gemcitabine
Gemcitabine results in increased methylation of SFN gene
[DNMT1 protein binds to SFN promoter] inhibits the reaction [Gemcitabine results in decreased susceptibility to Gemcitabine]; [Gemcitabine results in decreased susceptibility to Gemcitabine] inhibits the reaction [DNMT1 protein binds to SFN promoter]; [Gemcitabine results in decreased susceptibility to Gemcitabine] which results in decreased methylation of SFN gene; [Gemcitabine results in decreased susceptibility to Gemcitabine] which results in increased expression of SFN mRNA; [Gemcitabine results in decreased susceptibility to Gemcitabine] which results in increased expression of SFN protein; [UHRF1 protein promotes the reaction [DNMT1 protein binds to SFN promoter]] inhibits the reaction [Gemcitabine results in decreased susceptibility to Gemcitabine]; SFN protein affects the reaction [YAP1 protein promotes the reaction [SFN protein results in decreased susceptibility to Gemcitabine]]; SFN protein inhibits the reaction [Gemcitabine results in increased activity of and results in increased cleavage of CASP8 protein]; SFN protein inhibits the reaction [Gemcitabine results in increased cleavage of PARP1 protein]; SFN protein promotes the reaction [Gemcitabine results in decreased susceptibility to Gemcitabine]; YAP1 protein promotes the reaction [SFN protein results in decreased susceptibility to Gemcitabine] 		CTD PMID:25189999 PMID:26894857 NCBI chr 5:151,110,582...151,111,854
Ensembl chr 5:151,110,530...151,111,995 		JBrowse link
G Shh sonic hedgehog signaling molecule decreases expression ISO Gemcitabine results in decreased expression of SHH mRNA CTD PMID:20103597 NCBI chr 4:7,687,872...7,697,025
Ensembl chr 4:7,687,846...7,697,901 		JBrowse link
G Sirt3 sirtuin 3 decreases expression
multiple interactions 		ISO Gemcitabine results in decreased expression of SIRT3 protein
[3-(carbamoylamino)-5-(3-fluorophenyl)-N-(3-piperidyl)thiophene-2-carboxamide co-treated with Gemcitabine] results in decreased expression of SIRT3 protein 		CTD PMID:37798514 NCBI chr 1:205,371,703...205,394,145
Ensembl chr 1:205,371,710...205,394,076 		JBrowse link
G Slc25a29 solute carrier family 25 member 29 increases expression ISO Gemcitabine results in increased expression of SLC25A29 mRNA CTD PMID:17039268 NCBI chr 6:133,506,403...133,517,322
Ensembl chr 6:133,506,331...133,517,827 		JBrowse link
G Slc28a1 solute carrier family 28 member 1 multiple interactions EXP
ISO 		Gemcitabine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]
Gemcitabine inhibits the reaction [SLC28A1 protein results in increased transport of Uridine] 		CTD PMID:8713072 PMID:10772724 NCBI chr 1:144,490,453...144,532,025
Ensembl chr 1:144,490,623...144,531,544 		JBrowse link
G Slc29a1 solute carrier family 29 member 1 affects response to substance
increases response to substance
decreases response to substance
multiple interactions
increases uptake 		ISO SLC29A1 protein affects the susceptibility to Gemcitabine
SLC29A1 mRNA results in increased susceptibility to Gemcitabine; SLC29A1 protein results in increased susceptibility to Gemcitabine
SLC29A1 protein results in decreased susceptibility to Gemcitabine
4-nitrobenzylthioinosine inhibits the reaction [SLC29A1 protein results in increased uptake of Gemcitabine]; [S 1 (combination) results in increased expression of SLC29A1 mRNA] which results in increased uptake of Gemcitabine; Fluorouracil promotes the reaction [SLC29A1 protein results in increased uptake of Gemcitabine] 		CTD PMID:15501974 PMID:16868479 PMID:17695509 PMID:18383843 PMID:18452103 More... NCBI chr 9:22,897,099...22,911,640
Ensembl chr 9:22,902,471...22,914,620 		JBrowse link
G Slc29a3 solute carrier family 29 member 3 affects transport ISO SLC29A3 protein affects the transport of Gemcitabine CTD PMID:19164483 NCBI chr20:29,191,086...29,228,299
Ensembl chr20:29,191,127...29,228,299 		JBrowse link
G Slc2a3 solute carrier family 2 member 3 increases expression ISO Gemcitabine results in increased expression of SLC2A3 mRNA CTD PMID:17039268 NCBI chr 4:157,632,887...157,698,034
Ensembl chr 4:157,632,887...157,646,186 		JBrowse link
G Slc43a3 solute carrier family 43, member 3 decreases expression ISO Gemcitabine results in decreased expression of SLC43A3 mRNA CTD PMID:17039268 NCBI chr 3:90,414,822...90,450,654
Ensembl chr 3:90,415,977...90,436,976 		JBrowse link
G Slitrk2 SLIT and NTRK-like family, member 2 increases expression ISO Gemcitabine results in increased expression of SLITRK2 mRNA CTD PMID:17039268 NCBI chr  X:150,287,418...150,299,832
Ensembl chr  X:150,287,303...150,314,997 		JBrowse link
G Smg1 SMG1, nonsense mediated mRNA decay associated PI3K related kinase decreases response to substance
multiple interactions 		ISO SMG1 protein results in decreased susceptibility to Gemcitabine
SMG1 protein inhibits the reaction [Gemcitabine results in increased activity of CASP3 protein]; SMG1 protein inhibits the reaction [Gemcitabine results in increased activity of CASP9 protein] 		CTD PMID:21418860 NCBI chr 1:181,876,134...181,977,894
Ensembl chr 1:181,876,134...181,977,894 		JBrowse link
G Smo smoothened, frizzled class receptor increases expression ISO Gemcitabine results in increased expression of SMO mRNA CTD PMID:25605917 NCBI chr 4:59,311,084...59,341,280
Ensembl chr 4:59,311,041...59,341,281 		JBrowse link
G Sox2 SRY-box transcription factor 2 increases expression ISO Gemcitabine results in increased expression of SOX2 mRNA CTD PMID:25605917 NCBI chr 2:119,465,131...119,467,542
Ensembl chr 2:119,454,541...119,496,350 		JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression ISO Gemcitabine results in increased expression of SPP1 mRNA CTD PMID:17039268 NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase affects response to substance
multiple interactions
decreases response to substance 		ISO SRC protein affects the susceptibility to Gemcitabine
[AG 1879 co-treated with SRC] results in increased susceptibility to Gemcitabine
SRC protein modified form results in decreased susceptibility to Gemcitabine; SRC protein results in decreased susceptibility to Gemcitabine 		CTD PMID:15073106 PMID:15194078 NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:166,511,985...166,559,462 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases activity ISO Gemcitabine results in decreased activity of STAT3 protein CTD PMID:22348037 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359 		JBrowse link
G Syncrip synaptotagmin binding, cytoplasmic RNA interacting protein decreases expression ISO Gemcitabine results in decreased expression of SYNCRIP mRNA CTD PMID:17039268 NCBI chr 8:98,282,358...98,315,412
Ensembl chr 8:98,282,358...98,315,386 		JBrowse link
G Szrd1 SUZ RNA binding domain containing 1 decreases expression ISO Gemcitabine results in decreased expression of SZRD1 mRNA CTD PMID:17039268 NCBI chr 5:153,418,748...153,443,286
Ensembl chr 5:158,701,753...158,726,248 		JBrowse link
G Tceal9 transcription elongation factor A like 9 increases expression ISO Gemcitabine results in increased expression of TCEAL9 mRNA CTD PMID:17039268 NCBI chr  X:104,037,274...104,039,345
Ensembl chr  X:104,032,421...104,041,562 		JBrowse link
G Tcof1 treacle ribosome biogenesis factor 1 decreases expression ISO Gemcitabine results in decreased expression of TCOF1 mRNA CTD PMID:17039268 NCBI chr18:56,537,437...56,570,727
Ensembl chr18:56,537,437...56,570,727 		JBrowse link
G Tert telomerase reverse transcriptase multiple interactions
decreases activity 		ISO [Fluorouracil co-treated with Gemcitabine] results in decreased activity of TERT protein
Gemcitabine results in decreased activity of TERT protein 		CTD PMID:16929163 NCBI chr 1:31,465,766...31,488,650
Ensembl chr 1:31,466,056...31,488,111 		JBrowse link
G Tfap2a transcription factor AP-2 alpha increases response to substance
multiple interactions 		ISO TFAP2A protein results in increased susceptibility to Gemcitabine
[TFAP2A protein co-treated with TP53 gene mutant form] results in decreased susceptibility to Gemcitabine 		CTD PMID:21489314 NCBI chr17:24,230,064...24,253,219
Ensembl chr17:24,229,910...24,253,219 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
decreases response to substance 		ISO 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to Gemcitabine]]; EGF promotes the reaction [TGFB1 results in decreased susceptibility to Gemcitabine]; Erlotinib Hydrochloride inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to Gemcitabine]]; pyrazolanthrone inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to Gemcitabine]]; U 0126 inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to Gemcitabine]] CTD PMID:21613822 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 increases expression ISO Gemcitabine results in increased expression of TGFB2 mRNA CTD PMID:17039268 NCBI chr13:100,691,540...100,793,227
Ensembl chr13:100,692,953...100,792,856 		JBrowse link
G Thpo thrombopoietin increases expression ISO Gemcitabine results in increased expression of THPO protein CTD PMID:20531411 Ensembl chr11:93,686,834...93,693,320 JBrowse link
G Tnf tumor necrosis factor increases expression
affects expression 		ISO Gemcitabine results in increased expression of TNF protein
Gemcitabine affects the expression of TNF mRNA 		CTD PMID:17039268 PMID:20531411 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Tnfaip3 TNF alpha induced protein 3 increases expression ISO Gemcitabine results in increased expression of TNFAIP3 mRNA CTD PMID:17039268 NCBI chr 1:15,528,921...15,543,993
Ensembl chr 1:15,528,921...15,543,979 		JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B increases expression ISO Gemcitabine results in increased expression of TNFRSF11B mRNA CTD PMID:17039268 NCBI chr 7:87,456,318...87,484,324
Ensembl chr 7:87,456,319...87,485,075 		JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO [TNFSF10 co-treated with Gemcitabine] affects the localization of BAX protein; [TNFSF10 co-treated with Gemcitabine] results in increased activity of CASP8 protein CTD PMID:17671697 NCBI chr 2:112,136,550...112,155,903 JBrowse link
G Tnfsf8 TNF superfamily member 8 multiple interactions ISO [Gemcitabine co-treated with Erlotinib Hydrochloride] affects the expression of TNFSF8 protein CTD PMID:24979617 NCBI chr 5:82,266,436...82,292,858
Ensembl chr 5:82,266,436...82,292,858 		JBrowse link
G Tp53 tumor protein p53 increases expression
affects activity
multiple interactions 		ISO Gemcitabine results in increased expression of TP53 protein
Gemcitabine affects the activity of TP53 protein
[TFAP2A protein co-treated with TP53 gene mutant form] results in decreased susceptibility to Gemcitabine; Nicotine inhibits the reaction [Gemcitabine results in increased expression of TP53 protein]
[Gemcitabine co-treated with olsalazine] inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in decreased expression of TRP53 protein] 		CTD PMID:12082016 PMID:16601104 PMID:17671697 PMID:21489314 PMID:35435491 More... NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 increases expression ISO Gemcitabine results in increased expression of TP53BP1 mRNA CTD PMID:17039268 NCBI chr 3:128,620,320...128,724,716
Ensembl chr 3:128,620,322...128,696,747 		JBrowse link
G Tp53inp1 tumor protein p53 inducible nuclear protein 1 increases expression ISO Gemcitabine results in increased expression of TP53INP1 mRNA CTD PMID:16570353 PMID:17039268 NCBI chr 5:29,051,267...29,069,486
Ensembl chr 5:29,051,264...29,069,484 		JBrowse link
G Traf1 TNF receptor-associated factor 1 affects expression ISO Gemcitabine affects the expression of TRAF1 mRNA CTD PMID:17039268 NCBI chr 3:38,607,707...38,639,641
Ensembl chr 3:38,619,506...38,636,264 		JBrowse link
G Tube1 tubulin, epsilon 1 increases expression ISO Gemcitabine results in increased expression of TUBE1 mRNA CTD PMID:17039268 NCBI chr20:42,552,390...42,570,324
Ensembl chr20:44,107,022...44,125,271 		JBrowse link
G Tymp thymidine phosphorylase affects response to substance
multiple interactions 		ISO TYMP protein affects the susceptibility to Gemcitabine
[TYMP protein co-treated with DPYD protein] affects the susceptibility to Gemcitabine; TYMP protein affects the susceptibility to [Gemcitabine co-treated with Mitomycin] 		CTD PMID:18728667 NCBI chr 7:122,318,396...122,323,716
Ensembl chr 7:122,316,520...122,324,003 		JBrowse link
G Tyrp1 tyrosinase-related protein 1 affects expression ISO Gemcitabine affects the expression of TYRP1 mRNA CTD PMID:17039268 NCBI chr 5:100,327,111...100,345,657
Ensembl chr 5:100,327,125...100,345,657 		JBrowse link
G Ube2c ubiquitin-conjugating enzyme E2C decreases expression ISO Gemcitabine results in decreased expression of UBE2C mRNA CTD PMID:17039268 NCBI chr 3:173,925,975...173,928,375
Ensembl chr 3:173,925,934...173,932,678 		JBrowse link
G Uggt2 UDP-glucose glycoprotein glucosyltransferase 2 increases expression ISO Gemcitabine results in increased expression of UGGT2 mRNA CTD PMID:17039268 NCBI chr15:102,480,239...102,646,291
Ensembl chr15:102,480,781...102,646,410 		JBrowse link
G Uhrf1 ubiquitin-like with PHD and ring finger domains 1 multiple interactions ISO [Gemcitabine results in decreased susceptibility to Gemcitabine] which results in decreased expression of UHRF1 protein; [UHRF1 protein promotes the reaction [DNMT1 protein binds to SFN promoter]] inhibits the reaction [Gemcitabine results in decreased susceptibility to Gemcitabine]; UHRF1 protein inhibits the reaction [Gemcitabine results in decreased susceptibility to Gemcitabine] CTD PMID:25189999 NCBI chr 9:1,220,162...1,241,792
Ensembl chr 9:1,222,063...1,241,792 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 decreases expression ISO Gemcitabine results in decreased expression of VCAM1 protein CTD PMID:20531411 NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801 		JBrowse link
G Vegfa vascular endothelial growth factor A increases expression
multiple interactions 		ISO Gemcitabine results in increased expression of VEGFA mRNA
[Curcumin co-treated with Gemcitabine] results in decreased expression of VEGFA protein 		CTD PMID:17039268 PMID:17440100 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194 		JBrowse link
G Vgf VGF nerve growth factor inducible decreases expression ISO Gemcitabine results in decreased expression of VGF mRNA CTD PMID:17039268 NCBI chr12:25,274,004...25,281,803
Ensembl chr12:25,273,333...25,282,703 		JBrowse link
G Vldlr very low density lipoprotein receptor increases expression ISO Gemcitabine results in increased expression of VLDLR mRNA CTD PMID:17039268 NCBI chr 1:234,239,769...234,272,150
Ensembl chr 1:234,240,121...234,272,154 		JBrowse link
G Vmp1 vacuole membrane protein 1 increases expression ISO Gemcitabine results in increased expression of VMP1 CTD PMID:20299819 NCBI chr10:71,903,223...72,002,337
Ensembl chr10:71,903,227...72,002,319 		JBrowse link
G Vwf von Willebrand factor decreases expression ISO Gemcitabine results in decreased expression of VWF protein CTD PMID:20531411 NCBI chr 4:160,042,900...160,177,757
Ensembl chr 4:160,047,982...160,177,757 		JBrowse link
G Wnt5a Wnt family member 5A decreases expression ISO Gemcitabine results in decreased expression of WNT5A mRNA CTD PMID:17039268 NCBI chr16:3,702,300...3,724,860
Ensembl chr16:3,703,665...3,724,860 		JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions ISO Gemcitabine promotes the reaction [1-(2,3-dichlorobenzoyl)-5-methoxy-2-methyl-(2-(mopholin-4-yl)ethyl)-1H-indole results in increased expression of XBP1 mRNA]; Gemcitabine promotes the reaction [arachidonylcyclopropylamide results in increased expression of XBP1 mRNA]; Gemcitabine promotes the reaction [Rimonabant results in increased expression of XBP1 mRNA] CTD PMID:21525939 NCBI chr14:84,604,623...84,609,707
Ensembl chr14:84,604,107...84,609,706 		JBrowse link
G Xiap X-linked inhibitor of apoptosis affects response to substance ISO XIAP affects the susceptibility to Gemcitabine CTD PMID:16628085 NCBI chr  X:125,756,107...125,803,979
Ensembl chr  X:125,737,971...125,803,978 		JBrowse link
G Yap1 Yes1 associated transcriptional regulator multiple interactions
affects response to substance 		ISO Gemcitabine promotes the reaction [nuciferine results in decreased expression of and results in increased phosphorylation of YAP1 protein]; SFN protein affects the reaction [YAP1 protein promotes the reaction [SFN protein results in decreased susceptibility to Gemcitabine]]; YAP1 protein affects the reaction [Gemcitabine results in increased activity of and results in increased cleavage of CASP8 protein]; YAP1 protein affects the reaction [Gemcitabine results in increased cleavage of PARP1 protein]; YAP1 protein promotes the reaction [SFN protein results in decreased susceptibility to Gemcitabine]
YAP1 protein affects the susceptibility to Gemcitabine 		CTD PMID:26894857 PMID:31627466 NCBI chr 8:13,380,551...13,451,640
Ensembl chr 8:13,380,551...13,451,437 		JBrowse link
G Zfp110 zinc finger protein 110 increases expression ISO Gemcitabine results in increased expression of ZNF274 mRNA CTD PMID:17039268 NCBI chr 1:82,509,563...82,533,294
Ensembl chr 1:82,517,769...82,533,292 		JBrowse link
G Zfp449 zinc finger protein 449 increases expression ISO Gemcitabine results in increased expression of ZNF449 mRNA CTD PMID:17039268 NCBI chr  X:139,127,425...139,147,490
Ensembl chr  X:139,127,479...139,147,489 		JBrowse link
G Zfp521 zinc finger protein 521 decreases expression ISO Gemcitabine results in decreased expression of ZNF521 mRNA CTD PMID:17039268 NCBI chr18:5,050,297...5,343,188
Ensembl chr18:5,056,236...5,343,054 		JBrowse link
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Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      biological role 20818
        xenobiotic 19528
          gemcitabine 290
            gemcitabine hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            heteroorganic entity 20219
                              organochalcogen compound 19904
                                organooxygen compound 19806
                                  carbohydrates and carbohydrate derivatives 15487
                                    carbohydrate 15487
                                      carbohydrate derivative 14459
                                        glycosyl compound 13167
                                          N-glycosyl compound 5902
                                            nucleoside 5754
                                              deoxyribonucleoside 2902
                                                2'-deoxyribonucleoside 2257
                                                  pyrimidine 2'-deoxyribonucleoside 362
                                                    gemcitabine 290
                                                      gemcitabine hydrochloride 0
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