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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Berberrubine
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Accession:CHEBI:175111 term browser browse the term
Synonyms:exact_synonym: 17-methoxy-5,7-dioxa-13-azoniapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-1(13),2,4(8),9,14,16,18,20-octaen-16-ol;chloride
 related_synonym: Formula=C19H16NO4.Cl;   InChI=1S/C19H15NO4.ClH/c1-22-16-3-2-11-6-15-13-8-18-17(23-10-24-18)7-12(13)4-5-20(15)9-14(11)19(16)21;/h2-3,6-9H,4-5,10H2,1H3;1H;   InChIKey=GYFSYEVKFOOLFZ-UHFFFAOYSA-N;   SMILES=[Cl-].O1C=2C=C3CC[N+]4=C(C3=CC2OC1)C=C5C(=C4)C(O)=C(OC)C=C5
 xref: CAS:15401-69-1;   Chemspider:65547
 xref_mesh: MESH:C115958


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Berberrubine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [dehydrocostus lactone co-treated with berberrubine] results in increased expression of BAX protein CTD PMID:37142148 NCBI chr 1:105,076,472...105,081,906 JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO [dehydrocostus lactone co-treated with berberrubine] results in decreased expression of BCL2 protein CTD PMID:37142148 NCBI chr13:23,204,464...23,366,900 JBrowse link
G Casp3 caspase 3 multiple interactions ISO [dehydrocostus lactone co-treated with berberrubine] results in increased expression of CASP3 protein CTD PMID:37142148 NCBI chr16:52,395,539...52,413,794 JBrowse link
G Impdh2 inosine monophosphate dehydrogenase 2 multiple interactions ISO berberrubine binds to and results in decreased activity of IMPDH2 protein; berberrubine inhibits the reaction [Inosine Monophosphate binds to IMPDH2 protein] CTD PMID:37871880 NCBI chr 8:109,256,705...109,261,365 JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions ISO berberrubine inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of MKI67 protein] CTD PMID:37871880 NCBI chr 1:199,926,150...199,952,847 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19898
    role 19869
      biological role 19867
        biochemical role 19577
          metabolite 19563
            alkaloid 8026
              Berberrubine 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    main group molecular entity 19835
                      p-block molecular entity 19835
                        carbon group molecular entity 19774
                          organic molecular entity 19770
                            heteroorganic entity 19535
                              organonitrogen compound 18859
                                alkaloid 8026
                                  Berberrubine 5
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