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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:3',5'-cyclic AMP
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Accession:CHEBI:17489 term browser browse the term
Definition:A 3',5'-cyclic purine nucleotide having having adenine as the nucleobase.
Synonyms:exact_synonym: adenosine 3',5'-(hydrogen phosphate)
 related_synonym: Adenosine 3',5'-cyclic phosphate;   Adenosine 3',5'-phosphate;   Cyclic AMP;   Cyclic adenylic acid;   Formula=C10H12N5O6P;   InChI=1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/t4-,6-,7-,10-/m1/s1;   InChIKey=IVOMOUWHDPKRLL-KQYNXXCUSA-N;   SMILES=Nc1ncnc2n(cnc12)[C@@H]1O[C@@H]2COP(O)(=O)O[C@H]2[C@H]1O;   adenosine 3',5'-cyclic monophosphate;   cAMP
 alt_id: CHEBI:11673;   CHEBI:1325;   CHEBI:19827;   CHEBI:41588
 xref: CAS:60-92-4;   DrugBank:DB02527;   HMDB:HMDB0000058;   KEGG:C00575;   KNApSAcK:C00001497
 xref_mesh: MESH:D000242
 xref: MetaCyc:CAMP;   PDBeChem:CMP;   PMID:16295522;   PMID:18372334;   PMID:22770225;   Reaxys:52645;   Wikipedia:Cyclic_AMP
 cyclic_relationship: is_conjugate_acid_of CHEBI:58165


show annotations for term's descendants           Sort by:
3',5'-cyclic AMP term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G P2RY2 purinergic receptor P2Y2 multiple interactions EXP [Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Cyclic AMP; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Cyclic AMP] CTD PMID:10604969 NCBI chr21:24,987,568...25,009,754
Ensembl chr21:24,992,848...24,996,059 		JBrowse link
8-(4-chlorophenylthio)-cAMP term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CFTR CF transmembrane conductance regulator multiple interactions EXP [1-Methyl-3-isobutylxanthine co-treated with 8-((4-chlorophenyl)thio)cyclic-3',5'-AMP] results in increased activity of CFTR protein CTD PMID:15161604 NCBI chr14:56,290,417...56,452,919
Ensembl chr14:56,290,275...56,453,977 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 498
    role 498
      biological role 498
        biochemical role 456
          metabolite 447
            prokaryotic metabolite 393
              bacterial metabolite 393
                Escherichia coli metabolite 380
                  3',5'-cyclic AMP 2
                    (Rp)-cAMPS 0
                    (Sp)-8-bromo-cAMPS 0
                    (Sp)-cAMPS 0
                    1-NO-cAMP 0
                    2-(6-aminohexylamino)-cAMP 0
                    2-(dimethylamino)-cAMP 0
                    6-(dimethylamino)-cPuMP 0
                    8-(4-chlorophenylthio)-cAMP 1
                    8-(6-aminohexylamino)-cAMP 0
                    8-(6-aminohexylthio)-cAMP 0
                    8-Br-cAMP 0
                    8-PIP-cAMP 0
                    N(6)-(6-aminohexyl)-cAMP 0
                    N(6)-butyryl-cAMP 0
                    bucladesine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 498
    subatomic particle 498
      composite particle 498
        hadron 498
          baryon 498
            nucleon 498
              atomic nucleus 498
                atom 498
                  main group element atom 491
                    p-block element atom 491
                      chalcogen 447
                        oxygen atom 445
                          oxygen molecular entity 445
                            hydroxides 420
                              oxoacid 375
                                pnictogen oxoacid 14
                                  phosphorus oxoacid 9
                                    phosphoric acids 9
                                      phosphoric acid 9
                                        phosphoric acid derivative 8
                                          phosphate 8
                                            organic phosphate 8
                                              carbohydrate phosphate 3
                                                phospho sugar 3
                                                  aldose phosphate 3
                                                    aldopentose phosphate 3
                                                      ribose phosphate 3
                                                        ribonucleotide 3
                                                          purine ribonucleotide 2
                                                            adenyl ribonucleotide 2
                                                              3',5'-cyclic AMP 2
                                                                (Rp)-cAMPS 0
                                                                (Sp)-8-bromo-cAMPS 0
                                                                (Sp)-cAMPS 0
                                                                1-NO-cAMP 0
                                                                2-(6-aminohexylamino)-cAMP 0
                                                                2-(dimethylamino)-cAMP 0
                                                                6-(dimethylamino)-cPuMP 0
                                                                8-(4-chlorophenylthio)-cAMP 1
                                                                8-(6-aminohexylamino)-cAMP 0
                                                                8-(6-aminohexylthio)-cAMP 0
                                                                8-Br-cAMP 0
                                                                8-PIP-cAMP 0
                                                                N(6)-(6-aminohexyl)-cAMP 0
                                                                N(6)-butyryl-cAMP 0
                                                                bucladesine 0
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