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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:dithioerythritol
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Accession:CHEBI:17456 term browser browse the term
Definition:The meso-diastereomer of 1,4-dimercaptobutane-2,3-diol; a sulfur-containing sugar derived from the monosaccharide erythrose; and an epimer of dithiothreitol.
Synonyms:exact_synonym: (2R,3S)-1,4-disulfanylbutane-2,3-diol
 related_synonym: (2R*,3S*)-1,4-dimercapto-2,3-butanediol;   (2R,3S)-1,4-dimercaptobutane-2,3-diol;   1,4-dithioerythritol;   DTE;   Formula=C4H10O2S2;   InChI=1S/C4H10O2S2/c5-3(1-7)4(6)2-8/h3-8H,1-2H2/t3-,4+;   InChIKey=VHJLVAABSRFDPM-ZXZARUISSA-N;   SMILES=O[C@@H](CS)[C@H](O)CS;   erythro-1,4-Dimercapto-2,3-butanediol
 alt_id: CHEBI:14184;   CHEBI:23851;   CHEBI:42239;   CHEBI:4662
 xref: CAS:6892-68-8;   DrugBank:DB01692;   Gmelin:863505;   KEGG:C00950
 xref_mesh: MESH:D004226
 xref: PDBeChem:DTU;   PMID:14192894;   PMID:16901854;   PMID:22684514;   PMID:22845804;   PMID:23402788;   Reaxys:1719756;   Wikipedia:Dithioerythritol


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dithioerythritol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc1a5 solute carrier family 1 member 5 multiple interactions EXP Dithioerythritol inhibits the reaction [Thiazoles analog results in decreased activity of SLC1A5 protein] CTD PMID:23010140 NCBI chr 1:77,456,849...77,470,952
Ensembl chr 1:77,456,694...77,470,952 		JBrowse link
G Slc22a4 solute carrier family 22 member 4 multiple interactions ISO Dithioerythritol inhibits the reaction [Cadmium results in decreased activity of SLC22A4 protein]; Dithioerythritol inhibits the reaction [Mercury results in decreased activity of SLC22A4 protein]; Dithioerythritol inhibits the reaction [methylmercuric chloride results in decreased activity of SLC22A4 protein] CTD PMID:25490951 NCBI chr10:38,133,333...38,179,932
Ensembl chr10:38,133,322...38,179,720 		JBrowse link
G Slc22a5 solute carrier family 22 member 5 multiple interactions EXP Dithioerythritol inhibits the reaction [Mercuric Chloride results in decreased transport of SLC22A5 protein]; Dithioerythritol inhibits the reaction [Methylmercury Compounds results in decreased transport of SLC22A5 protein]; Dithioerythritol inhibits the reaction [Omeprazole inhibits the reaction [SLC22A5 protein results in increased transport of Carnitine]] CTD PMID:19041296 PMID:22900493 NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309 		JBrowse link
G Slc25a20 solute carrier family 25 member 20 multiple interactions EXP
ISO		 Dithioerythritol inhibits the reaction [Hydrogen Peroxide results in decreased activity of SLC25A20 protein]
Dithioerythritol inhibits the reaction [Mercuric Chloride results in decreased activity of SLC25A20 protein]; Dithioerythritol inhibits the reaction [methylmercuric chloride results in decreased activity of SLC25A20 protein]		 CTD PMID:23402788 PMID:25849418 NCBI chr 8:109,365,056...109,386,512
Ensembl chr 8:109,365,002...109,386,512 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      chemical role 19479
        reducing agent 219
          dithioerythritol 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    main group molecular entity 19817
                      s-block molecular entity 19653
                        hydrogen molecular entity 19634
                          hydrides 19144
                            inorganic hydride 18161
                              chalcogen hydride 2590
                                sulfur hydride 2101
                                  hydrogen sulfide 2101
                                    thiol group 1982
                                      thiol 1982
                                        1,4-dimercaptobutane-2,3-diol 104
                                          dithioerythritol 4
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