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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:agmatine
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Accession:CHEBI:17431 term browser browse the term
Definition:A guanidine that has formula C5H14N4.
Synonyms:related_synonym: (4-aminobutyl)guanidine;   1-(4-aminobutyl)guanidine;   Formula=C5H14N4;   InChI=1S/C5H14N4/c6-3-1-2-4-9-5(7)8/h1-4,6H2,(H4,7,8,9);   InChIKey=QYPPJABKJHAVHS-UHFFFAOYSA-N;   N-(4-aminobutyl)guanidine;   SMILES=NCCCCNC(N)=N
 alt_id: CHEBI:13747;   CHEBI:18576;   CHEBI:2514;   CHEBI:40556
 xref: CAS:306-60-5;   KEGG:C00179;   KNApSAcK:C00001400
 xref_mesh: MESH:D000376
 cyclic_relationship: is_conjugate_base_of CHEBI:58145


show annotations for term's descendants           Sort by:
agmatine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO Agmatine inhibits the reaction [Palmitic Acid results in decreased phosphorylation of AKT1 protein]; dorsomorphin inhibits the reaction [Agmatine inhibits the reaction [Palmitic Acid results in decreased phosphorylation of AKT1 protein]] CTD PMID:35747990 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G App amyloid beta precursor protein decreases abundance
multiple interactions		 ISO APP protein results in decreased abundance of Agmatine
Agmatine inhibits the reaction [APP protein results in decreased expression of BDNF protein]; Agmatine inhibits the reaction [APP protein results in decreased expression of MME protein]; Agmatine inhibits the reaction [APP protein results in increased expression of IL6 protein]; Agmatine inhibits the reaction [APP protein results in increased expression of MAPT protein]; Agmatine inhibits the reaction [APP protein results in increased expression of TNF protein]		 CTD PMID:32522471 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions ISO Agmatine inhibits the reaction [APP protein results in decreased expression of BDNF protein] CTD PMID:32522471 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Edn1 endothelin 1 multiple interactions ISO Agmatine inhibits the reaction [Palmitic Acid results in decreased expression of EDN1 protein] CTD PMID:35747990 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Ednra endothelin receptor type A multiple interactions ISO Agmatine inhibits the reaction [Palmitic Acid results in decreased expression of EDNRA protein] CTD PMID:35747990 NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049 		JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Agmatine inhibits the reaction [Morphine results in increased expression of FOSB protein] CTD PMID:15899480 NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465 		JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions ISO Agmatine inhibits the reaction [MBP protein results in increased expression of GFAP protein]; NOS2 gene mutant form promotes the reaction [Agmatine inhibits the reaction [MBP protein results in increased expression of GFAP protein]] CTD PMID:24070732 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589 		JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 multiple interactions EXP Agmatine inhibits the reaction [Morphine results in increased expression of GRIN1 protein] CTD PMID:20950603 NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Agmatine inhibits the reaction [Rotenone results in increased expression of IL1B protein] CTD PMID:30001633 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO Agmatine inhibits the reaction [APP protein results in increased expression of IL6 protein]; Agmatine inhibits the reaction [Valproic Acid results in increased expression of IL6 protein] CTD PMID:30273971 PMID:32522471 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO Agmatine inhibits the reaction [APP protein results in increased expression of MAPT protein] CTD PMID:32522471 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129 		JBrowse link
G Mbp myelin basic protein multiple interactions ISO Agmatine inhibits the reaction [MBP protein results in increased expression of GFAP protein]; Agmatine inhibits the reaction [MBP protein results in increased expression of TFRC protein]; NOS2 gene mutant form promotes the reaction [Agmatine inhibits the reaction [MBP protein results in increased expression of GFAP protein]] CTD PMID:24070732 NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404 		JBrowse link
G Mme membrane metallo-endopeptidase multiple interactions ISO Agmatine inhibits the reaction [APP protein results in decreased expression of MME protein] CTD PMID:32522471 NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Agmatine inhibits the reaction [Valproic Acid results in increased expression of NOS2 protein]; NOS2 gene mutant form promotes the reaction [Agmatine inhibits the reaction [MBP protein results in increased expression of GFAP protein]] CTD PMID:24070732 PMID:30273971 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO Agmatine inhibits the reaction [Palmitic Acid results in increased activity of and results in decreased phosphorylation of NOS3 protein]; dorsomorphin inhibits the reaction [Agmatine inhibits the reaction [Palmitic Acid results in increased activity of and results in decreased phosphorylation of NOS3 protein]] CTD PMID:35747990 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Agmatine inhibits the reaction [Valproic Acid results in increased expression of RELA protein] CTD PMID:30273971 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Agmatine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637 		JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Agmatine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904 		JBrowse link
G Tfrc transferrin receptor multiple interactions ISO Agmatine inhibits the reaction [MBP protein results in increased expression of TFRC protein] CTD PMID:24070732 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257 		JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP Agmatine inhibits the reaction [Morphine results in increased expression of TH protein] CTD PMID:15541421 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP		 Agmatine inhibits the reaction [APP protein results in increased expression of TNF protein]; Agmatine inhibits the reaction [Valproic Acid results in increased expression of TNF protein]
Agmatine inhibits the reaction [Rotenone results in increased expression of TNF protein]		 CTD PMID:30001633 PMID:30273971 PMID:32522471 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19917
    role 19887
      application 19730
        NMR chemical shift reference compound 18074
          ammonia 17895
            organic amino compound 17895
              primary amino compound 9350
                agmatine 21
                  N(1)-aminoaminopropylagmatine 0
                  N(4)-phosphoagmatine 0
                  acetylagmatine 0
                  agmatidine 0
                  alpha-allenylagmatine 0
                  feruloylagmatine + 0
                  p-coumaroylagmatine + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19917
    subatomic particle 19915
      composite particle 19915
        hadron 19915
          baryon 19915
            nucleon 19915
              atomic nucleus 19915
                atom 19915
                  main group element atom 19855
                    main group molecular entity 19855
                      s-block molecular entity 19666
                        hydrogen molecular entity 19668
                          hydrides 19176
                            inorganic hydride 18187
                              pnictogen hydride 18177
                                nitrogen hydride 18090
                                  azane 17896
                                    ammonia 17895
                                      organic amino compound 17895
                                        primary amino compound 9350
                                          agmatine 21
                                            N(1)-aminoaminopropylagmatine 0
                                            N(4)-phosphoagmatine 0
                                            acetylagmatine 0
                                            agmatidine 0
                                            alpha-allenylagmatine 0
                                            feruloylagmatine + 0
                                            p-coumaroylagmatine + 0
paths to the root