Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:2-trans,6-trans-farnesyl diphosphate
go back to main search page
Accession:CHEBI:17407 term browser browse the term
Definition:The trans,trans-stereoisomer of farnesyl diphosphate.
Synonyms:exact_synonym: (2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl trihydrogen diphosphate
 related_synonym: (2E,6E)-farnesol diphosphate;   (2E,6E)-farnesyl diphosphate;   (2E,6E)-farnesyl pyrophosphate;   (E,E)-farnesyl pyrophosphate;   (all-E)-farnesyl diphosphate;   2-trans,6-trans-farnesyl pyrophosphate;   Farnesyl diphosphate;   Farnesyl pyrophosphate;   Formula=C15H28O7P2;   InChI=1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)/b14-9+,15-11+;   InChIKey=VWFJDQUYCIWHTN-YFVJMOTDSA-N;   SMILES=CC(C)=CCC\\C(C)=C\\CC\\C(C)=C\\COP(O)(=O)OP(O)(O)=O;   all-trans-farnesyl pyrophosphate;   trans,trans-Farnesyl diphosphate
 alt_id: CHEBI:10700;   CHEBI:11488;   CHEBI:11491;   CHEBI:12854;   CHEBI:12874;   CHEBI:19789;   CHEBI:42496
 xref: Beilstein:2482197;   CAS:13058-04-3;   CAS:372-97-4;   KEGG:C00448;   KNApSAcK:C00000907;   KNApSAcK:C00007268;   LIPID_MAPS_instance:LMPR0103010002
 xref_mesh: MESH:C004808
 xref: PDBeChem:FPP;   PMID:7753173;   Reaxys:2482197
 cyclic_relationship: is_conjugate_acid_of CHEBI:175763



show annotations for term's descendants           Sort by:
2-trans,6-trans-farnesyl diphosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO farnesyl pyrophosphate inhibits the reaction [Simvastatin results in decreased phosphorylation of AKT1 protein] CTD PMID:33034787 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO farnesyl pyrophosphate inhibits the reaction [Lovastatin results in decreased expression of BIRC5 protein] CTD PMID:17472962 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Bmp2 bone morphogenetic protein 2 multiple interactions ISO farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF protein inhibits the reaction [BMP2 results in increased expression of RUNX2 mRNA]]] CTD PMID:18310456 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397
JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP
farnesyl pyrophosphate inhibits the reaction [Lovastatin results in increased activity of and results in increased cleavage of CASP3 protein]
farnesyl pyrophosphate inhibits the reaction [Simvastatin results in increased activity of CASP3 protein]
CTD PMID:15200425 PMID:18766339 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 multiple interactions EXP farnesyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of CYP17A1 mRNA] CTD PMID:21918126 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
JBrowse link
G Fnta farnesyltransferase, CAAX box, subunit alpha multiple interactions EXP [FNTA protein binds to FNTB protein] binds to [farnesyl pyrophosphate analog co-treated with KRAS protein] CTD PMID:10673434 NCBI chr16:66,065,131...66,083,460
Ensembl chr16:66,065,132...66,083,460
JBrowse link
G Fntb farnesyltransferase, CAAX box, subunit beta multiple interactions EXP [FNTA protein binds to FNTB protein] binds to [farnesyl pyrophosphate analog co-treated with KRAS protein] CTD PMID:10673434 NCBI chr 6:95,536,540...95,619,587
Ensembl chr 6:95,470,683...95,619,586
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO farnesyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of FOS mRNA] CTD PMID:16005304 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Foxo1 forkhead box O1 multiple interactions ISO farnesyl pyrophosphate inhibits the reaction [Simvastatin results in decreased phosphorylation of FOXO1 protein] CTD PMID:33034787 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions ISO [Lovastatin results in decreased activity of HMGCR protein] which results in decreased abundance of farnesyl pyrophosphate CTD PMID:17208200 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions ISO farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased activity of HRAS protein]]; farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased localization of HRAS protein]] CTD PMID:18625914 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO farnesyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of ICAM1 protein]] CTD PMID:10946302 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Il12b interleukin 12B multiple interactions ISO farnesyl pyrophosphate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL12B protein] CTD PMID:15187114 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO farnesyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of ICAM1 protein]]; farnesyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of SELE protein]] CTD PMID:10946302 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Kras KRAS proto-oncogene, GTPase multiple interactions EXP [FNTA protein binds to FNTB protein] binds to [farnesyl pyrophosphate analog co-treated with KRAS protein] CTD PMID:10673434 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased phosphorylation of MAPK1 protein]] CTD PMID:18310456 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased phosphorylation of MAPK3 protein]] CTD PMID:18310456 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased phosphorylation of MAPK8 protein]] CTD PMID:18310456 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Smoke analog results in increased expression of MMP9 mRNA]]; farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Smoke analog results in increased secretion of MMP9 protein]] CTD PMID:19299917 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mvk mevalonate kinase decreases activity
multiple interactions
decreases chemical synthesis
ISO farnesyl pyrophosphate results in decreased activity of MVK protein
farnesyl pyrophosphate inhibits the reaction [MVK protein results in increased hydrolysis of Adenosine Triphosphate]; farnesyl pyrophosphate inhibits the reaction [MVK protein results in increased phosphorylation of Mevalonic Acid]
MVK protein mutant form results in decreased chemical synthesis of farnesyl pyrophosphate
CTD PMID:9392419 PMID:24073415 NCBI chr12:42,141,391...42,158,893
Ensembl chr12:42,141,384...42,158,882
JBrowse link
G Pon1 paraoxonase 1 multiple interactions ISO farnesyl pyrophosphate inhibits the reaction [pitavastatin results in increased expression of PON1 mRNA]; farnesyl pyrophosphate inhibits the reaction [Simvastatin results in increased expression of PON1 mRNA] CTD PMID:14500290 PMID:15690306 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions ISO farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased activity of RAC1 protein]]; farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased localization of RAC1 protein]] CTD PMID:18625914 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251
JBrowse link
G Rhoa ras homolog family member A multiple interactions ISO farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in decreased activity of RHOA protein]]
farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF affects the localization of RHOA protein]]
CTD PMID:18310456 PMID:18625914 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions ISO farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF protein inhibits the reaction [BMP2 results in increased expression of RUNX2 mRNA]]] CTD PMID:18310456 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167
JBrowse link
G Sele selectin E multiple interactions ISO farnesyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of SELE protein]] CTD PMID:10946302 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF affects the localization of RHOA protein]]; farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF protein inhibits the reaction [BMP2 results in increased expression of RUNX2 mRNA]]]; farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased phosphorylation of MAPK1 protein]]; farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased phosphorylation of MAPK3 protein]]; farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased phosphorylation of MAPK8 protein]] CTD PMID:18310456 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    role 19854
      biological role 19852
        biochemical role 19582
          metabolite 19562
            prokaryotic metabolite 18618
              bacterial metabolite 18592
                Escherichia coli metabolite 18527
                  2-trans,6-trans-farnesyl diphosphate 26
                    (2E,6E,10E)-omega-hydroxyfarnesyl diphosphate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    p-block element atom 19849
                      chalcogen 19598
                        oxygen atom 19570
                          oxygen molecular entity 19570
                            hydroxides 19374
                              oxoacid 18808
                                pnictogen oxoacid 14987
                                  phosphorus oxoacid 14587
                                    phosphoric acids 13935
                                      phosphoric acid 13935
                                        phosphoric acid derivative 13817
                                          phosphate 13843
                                            organic phosphate 13816
                                              phospholipid 322
                                                isoprenoid phosphate 75
                                                  prenol phosphate 75
                                                    polyprenol phosphate 66
                                                      farnesyl phosphate 26
                                                        farnesyl diphosphate 26
                                                          2-trans,6-trans-farnesyl diphosphate 26
                                                            (2E,6E,10E)-omega-hydroxyfarnesyl diphosphate 0
paths to the root