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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cytidine 5'-monophosphate
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Accession:CHEBI:17361 term browser browse the term
Definition:A pyrimidine ribonucleoside 5'-monophosphate having cytosine as the nucleobase.
Synonyms:exact_synonym: 5'-cytidylic acid
 related_synonym: CMP;   Cytidylic acid;   Formula=C9H14N3O8P;   InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1;   InChIKey=IERHLVCPSMICTF-XVFCMESISA-N;   SMILES=Nc1ccn([C@@H]2O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]2O)c(=O)n1;   cytidylate;   pC
 alt_id: CHEBI:13274;   CHEBI:23520;   CHEBI:3275;   CHEBI:41312;   CHEBI:41319;   CHEBI:41666;   CHEBI:41691;   CHEBI:47362;   CHEBI:48799
 xref: CAS:63-37-6;   DrugBank:DB03403;   HMDB:HMDB0000095;   KEGG:C00055;   KEGG:G10621
 xref_mesh: MESH:D003568
 xref: MetaCyc:CMP;   PDBeChem:C5P;   PMID:21968653;   PMID:22991951;   PMID:24053133;   PMID:2559771;   Reaxys:46982
 cyclic_relationship: is_conjugate_acid_of CHEBI:60377



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cytidine 5'-monophosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdipt CDP-diacylglycerol--inositol 3-phosphatidyltransferase multiple interactions ISO [delta-hexachlorocyclohexane results in decreased activity of CDIPT protein] which results in decreased abundance of Cytidine Monophosphate; [Inositol promotes the reaction [CDIPT protein results in increased metabolism of Cytidine Diphosphate Diglycerides]] which results in increased abundance of Cytidine Monophosphate CTD PMID:2579070 NCBI chr 1:181,583,098...181,587,409
Ensembl chr 1:181,583,141...181,587,408
JBrowse link
CMP-N-acetyl-beta-neuraminic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cmas cytidine monophosphate N-acetylneuraminic acid synthetase affects abundance ISO CMAS protein affects the abundance of Cytidine Monophosphate N-Acetylneuraminic Acid CTD PMID:27380425 NCBI chr 4:175,718,808...175,737,128
Ensembl chr 4:175,718,808...175,737,125
JBrowse link
poly(cytidylic acid) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 multiple interactions
increases expression
EXP Minocycline inhibits the reaction [Poly C results in increased expression of GRIA1 mRNA] CTD PMID:19660546 NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A increases expression
multiple interactions
EXP Poly C results in increased expression of GRIN2A mRNA
Minocycline inhibits the reaction [Poly C results in increased expression of GRIN2A mRNA]
CTD PMID:19660546 NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637
JBrowse link
G Grin2c glutamate ionotropic receptor NMDA type subunit 2C multiple interactions
increases expression
EXP Minocycline inhibits the reaction [Poly C results in increased expression of GRIN2C mRNA] CTD PMID:19660546 NCBI chr10:100,488,430...100,507,083
Ensembl chr10:100,488,431...100,506,427
JBrowse link
G Il1b interleukin 1 beta increases expression EXP Poly C results in increased expression of IL1B protein CTD PMID:19660546 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
poly(I:C) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abhd2 abhydrolase domain containing 2, acylglycerol lipase multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of ABHD2 mRNA CTD PMID:26923065 NCBI chr 1:133,217,403...133,298,564
Ensembl chr 1:133,217,375...133,299,061
JBrowse link
G Ablim1 actin-binding LIM protein 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of ABLIM1 mRNA CTD PMID:26923065 NCBI chr 1:256,083,747...256,372,075
Ensembl chr 1:256,084,297...256,371,969
JBrowse link
G Acads acyl-CoA dehydrogenase short chain multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of ACADS mRNA CTD PMID:26923065 NCBI chr12:41,493,650...41,502,897
Ensembl chr12:41,493,626...41,502,898
JBrowse link
G Adam10 ADAM metallopeptidase domain 10 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of ADAM10 mRNA CTD PMID:26923065 NCBI chr 8:71,346,008...71,477,889
Ensembl chr 8:71,345,837...71,477,889
JBrowse link
G Adar adenosine deaminase, RNA-specific affects localization ISO Poly I-C affects the localization of ADAR protein CTD PMID:22240577 NCBI chr 2:175,138,391...175,178,280
Ensembl chr 2:175,138,403...175,178,282
JBrowse link
G Ahcyl1 adenosylhomocysteinase-like 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of AHCYL1 mRNA CTD PMID:26923065 NCBI chr 2:195,294,149...195,328,586
Ensembl chr 2:195,294,153...195,345,815
JBrowse link
G Ahr aryl hydrocarbon receptor increases expression ISO Poly I-C results in increased expression of AHR mRNA; Poly I-C results in increased expression of AHR protein CTD PMID:27783115 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Akap5 A-kinase anchoring protein 5 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of AKAP5 mRNA CTD PMID:26923065 NCBI chr 6:95,051,527...95,061,075
Ensembl chr 6:95,051,537...95,061,578
JBrowse link
G App amyloid beta precursor protein multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of APP mRNA CTD PMID:26923065 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Appl1 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 increases degradation
multiple interactions
ISO Poly I-C results in increased degradation of APPL1 protein
APPL1 protein inhibits the reaction [Poly I-C results in increased expression of IL1B protein]; APPL1 protein inhibits the reaction [Poly I-C results in increased expression of TNF protein]; APPL1 protein promotes the reaction [Poly I-C results in increased expression of CCL5 mRNA]; APPL1 protein promotes the reaction [Poly I-C results in increased expression of CXCL10 mRNA]; APPL1 protein promotes the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; APPL1 protein promotes the reaction [Poly I-C results in increased phosphorylation of IKBKE protein]; APPL1 protein promotes the reaction [Poly I-C results in increased phosphorylation of IRF3 protein]; APPL1 protein promotes the reaction [Poly I-C results in increased phosphorylation of TBK1 protein]; bafilomycin A1 promotes the reaction [Poly I-C results in increased degradation of APPL1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Poly I-C results in increased degradation of APPL1 protein]; Chloroquine inhibits the reaction [Poly I-C results in increased degradation of APPL1 protein]; trametinib inhibits the reaction [Poly I-C results in increased degradation of APPL1 protein]; U 0126 inhibits the reaction [Poly I-C results in increased degradation of APPL1 protein]
CTD PMID:25780039 NCBI chr16:2,118,503...2,166,741
Ensembl chr16:2,121,255...2,166,692
JBrowse link
G Arc activity-regulated cytoskeleton-associated protein affects methylation EXP Poly I-C affects the methylation of ARC promoter CTD PMID:32843831 NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378
JBrowse link
G Arfgef3 ARFGEF family member 3 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of ARFGEF3 mRNA CTD PMID:26923065 NCBI chr 1:13,245,578...13,404,319
Ensembl chr 1:13,244,830...13,404,084
JBrowse link
G Arg2 arginase 2 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of ARG2 mRNA CTD PMID:26923065 NCBI chr 6:97,936,002...97,961,379
Ensembl chr 6:97,936,002...97,961,378
JBrowse link
G Arhgap11a Rho GTPase activating protein 11A multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of ARHGAP11A mRNA CTD PMID:26923065 NCBI chr 3:100,590,865...100,607,146
Ensembl chr 3:100,590,865...100,607,559
JBrowse link
G Arhgap44 Rho GTPase activating protein 44 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of ARHGAP44 mRNA CTD PMID:26923065 NCBI chr10:49,655,583...49,822,876
Ensembl chr10:49,655,584...49,824,297
JBrowse link
G Arhgap9 Rho GTPase activating protein 9 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of ARHGAP9 mRNA CTD PMID:26923065 NCBI chr 7:63,148,573...63,157,025
Ensembl chr 7:63,148,900...63,157,524
JBrowse link
G Arhgef12 Rho guanine nucleotide exchange factor 12 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of ARHGEF12 mRNA CTD PMID:26923065 NCBI chr 8:43,350,070...43,475,404
Ensembl chr 8:43,353,799...43,476,366
JBrowse link
G Arhgef7 Rho guanine nucleotide exchange factor 7 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of ARHGEF7 mRNA CTD PMID:26923065 NCBI chr16:77,671,021...77,782,593
Ensembl chr16:77,671,023...77,782,697
JBrowse link
G Arsb arylsulfatase B multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of ARSB mRNA CTD PMID:26923065 NCBI chr 2:25,002,210...25,162,675
Ensembl chr 2:25,002,346...25,162,671
JBrowse link
G Art3 ADP-ribosyltransferase 3 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of ART3 mRNA CTD PMID:26923065 NCBI chr14:15,637,230...15,719,442
Ensembl chr14:15,637,237...15,665,407
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Poly I-C results in increased expression of ATF3 mRNA CTD PMID:27783115 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
JBrowse link
G Atp2b2 ATPase plasma membrane Ca2+ transporting 2 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of ATP2B2 mRNA CTD PMID:26923065 NCBI chr 4:146,894,602...147,208,060
Ensembl chr 4:146,896,332...147,140,665
JBrowse link
G Atxn3 ataxin 3 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of ATXN3 mRNA CTD PMID:26923065 NCBI chr 6:121,072,228...121,107,902
Ensembl chr 6:121,074,448...121,107,902
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Poly I-C results in increased expression of BAX protein CTD PMID:21418039 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Poly I-C results in decreased expression of BCL2 protein CTD PMID:21418039 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bcl2a1 BCL2-related protein A1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of BCL2A1 mRNA CTD PMID:26923065 NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions
affects methylation
ISO
EXP
[Poly I-C results in increased susceptibility to 4-iodo-2,5-dimethoxyphenylisopropylamine] which results in increased expression of BDNF mRNA; Poly I-C promotes the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of BDNF mRNA]
Poly I-C affects the methylation of BDNF promoter
CTD PMID:24889602 PMID:32843831 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Bid BH3 interacting domain death agonist decreases expression ISO Poly I-C results in decreased expression of BID protein CTD PMID:21418039 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO Poly I-C promotes the reaction [arsenic trioxide results in decreased expression of BIRC5 protein] CTD PMID:21418039 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Birc6 baculoviral IAP repeat-containing 6 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of BIRC6 mRNA CTD PMID:26923065 NCBI chr 6:20,722,922...20,916,396
Ensembl chr 6:20,722,922...20,916,434
JBrowse link
G Blmh bleomycin hydrolase multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of BLMH mRNA CTD PMID:26923065 NCBI chr10:61,772,112...61,815,212
Ensembl chr10:61,758,478...61,815,212
JBrowse link
G Bltp1 bridge-like lipid transfer protein family member 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of BLTP1 mRNA CTD PMID:26923065 NCBI chr 2:119,708,114...119,924,697
Ensembl chr 2:119,708,209...119,924,695
JBrowse link
G Bola2-ps4 bolA family member 2, pseudogene 4 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of BOLA2-PS4 mRNA CTD PMID:26923065 NCBI chr 3:153,272,435...153,272,781 JBrowse link
G Brms1l BRMS1 like transcriptional repressor multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of BRMS1L mRNA CTD PMID:26923065 NCBI chr 6:73,266,673...73,300,630
Ensembl chr 6:73,266,691...73,300,631
JBrowse link
G Brox BRO1 domain and CAAX motif containing multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of BROX mRNA CTD PMID:26923065 NCBI chr13:94,920,107...94,940,189
Ensembl chr13:94,920,112...94,940,227
JBrowse link
G C10h16orf90 similar to human chromosome 16 open reading frame 90 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of C10H16ORF90 mRNA CTD PMID:26923065 NCBI chr10:11,618,867...11,632,151
Ensembl chr10:11,618,348...11,629,910
JBrowse link
G C1qtnf7 C1q and TNF related 7 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of C1QTNF7 mRNA CTD PMID:26923065 NCBI chr14:67,467,888...67,580,477
Ensembl chr14:67,468,014...67,580,410
JBrowse link
G Cage1 cancer antigen 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of CAGE1 mRNA CTD PMID:26923065 NCBI chr17:26,789,975...26,828,210
Ensembl chr17:26,790,033...26,828,204
JBrowse link
G Car3 carbonic anhydrase 3 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of CA3 mRNA CTD PMID:26923065 NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO Acetylcysteine inhibits the reaction [arsenic trioxide promotes the reaction [Poly I-C results in increased activity of CASP3 protein]]; Acetylcysteine inhibits the reaction [Poly I-C promotes the reaction [arsenic trioxide results in increased activity of CASP3 protein]]; arsenic trioxide promotes the reaction [Poly I-C results in increased activity of CASP3 protein]; Poly I-C promotes the reaction [arsenic trioxide results in increased activity of CASP3 protein] CTD PMID:21418039 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 multiple interactions
increases activity
ISO arsenic trioxide promotes the reaction [Poly I-C results in increased activity of CASP8 protein]; Poly I-C promotes the reaction [arsenic trioxide results in increased activity of CASP8 protein] CTD PMID:21418039 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity
ISO Acetylcysteine inhibits the reaction [arsenic trioxide promotes the reaction [Poly I-C results in increased activity of CASP9 protein]]; Acetylcysteine inhibits the reaction [Poly I-C promotes the reaction [arsenic trioxide results in increased activity of CASP9 protein]]; arsenic trioxide promotes the reaction [Poly I-C results in increased activity of CASP9 protein]; Poly I-C promotes the reaction [arsenic trioxide results in increased activity of CASP9 protein] CTD PMID:21418039 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase decreases expression EXP Poly I-C results in decreased expression of CAT mRNA CTD PMID:23939143 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cav1 caveolin 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of CAV1 mRNA CTD PMID:26923065 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
JBrowse link
G Cbx1 chromobox 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of CBX1 mRNA CTD PMID:26923065 NCBI chr10:81,770,307...81,789,981
Ensembl chr10:81,770,342...81,791,096
JBrowse link
G Cbx6 chromobox 6 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of CBX6 mRNA CTD PMID:26923065 NCBI chr 7:111,372,979...111,383,026
Ensembl chr 7:111,372,980...111,383,091
JBrowse link
G Ccdc113 coiled-coil domain containing 113 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of CCDC113 mRNA CTD PMID:26923065 NCBI chr19:9,497,000...9,516,917
Ensembl chr19:9,496,886...9,516,923
JBrowse link
G Ccl1 C-C motif chemokine ligand 1 increases expression ISO Poly I-C results in increased expression of CCL1 mRNA CTD PMID:27783115 NCBI chr10:67,128,331...67,131,109
Ensembl chr10:67,128,331...67,131,159
JBrowse link
G Ccl11 C-C motif chemokine ligand 11 multiple interactions
increases secretion
ISO methyldithiocarbamate inhibits the reaction [Poly I-C results in increased secretion of CCL11 protein] CTD PMID:24056979 NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases secretion
increases expression
ISO
EXP
methyldithiocarbamate inhibits the reaction [Poly I-C results in increased secretion of CCL2 protein]
Poly I-C results in increased expression of CCL2 mRNA
CTD PMID:23939143 PMID:24056979 PMID:34740670 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions
increases expression
ISO Ethanol inhibits the reaction [Poly I-C results in increased expression of CCL3 protein] CTD PMID:19500611 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 multiple interactions
increases expression
increases secretion
ISO Ethanol inhibits the reaction [Poly I-C results in increased expression of CCL4 protein]; methyldithiocarbamate inhibits the reaction [Poly I-C results in increased secretion of CCL4 protein]
6-formylindolo(3,2-b)carbazole inhibits the reaction [Poly I-C results in increased expression of CCL4 mRNA]; Tetrachlorodibenzodioxin inhibits the reaction [Poly I-C results in increased expression of CCL4 mRNA]
CTD PMID:19500611 PMID:24056979 PMID:27783115 NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions
increases expression
increases secretion
ISO APPL1 protein promotes the reaction [Poly I-C results in increased expression of CCL5 mRNA]; methyldithiocarbamate inhibits the reaction [Poly I-C results in increased secretion of CCL5 protein]; trametinib promotes the reaction [Poly I-C results in increased expression of CCL5 mRNA]
Poly I-C results in increased expression of CCL5; Poly I-C results in increased expression of CCL5 mRNA
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; [Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA; amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; helenalin inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; IL4 protein promotes the reaction [Poly I-C results in increased expression of CCL5 mRNA]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; Particulate Matter inhibits the reaction [Poly I-C results in increased expression of CCL5]; Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; Vehicle Emissions inhibits the reaction [Poly I-C results in increased expression of CCL5]
CTD PMID:23688403 PMID:24056979 PMID:24709138 PMID:25780039 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Cd40 CD40 molecule increases expression
multiple interactions
ISO Poly I-C results in increased expression of CD40 protein
[Poly I-C co-treated with IFNG protein] results in increased secretion of CD40 protein
CTD PMID:15246609 PMID:16224278 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
JBrowse link
G Cd80 Cd80 molecule increases expression ISO Poly I-C results in increased expression of CD80 protein CTD PMID:15246609 NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030
JBrowse link
G Cd83 CD83 molecule increases expression
multiple interactions
ISO Poly I-C results in increased expression of CD83 protein
CEP-11004 inhibits the reaction [Poly I-C results in increased expression of CD83 protein]; SB 203580 inhibits the reaction [Poly I-C results in increased expression of CD83 protein]
CTD PMID:17698565 NCBI chr17:20,887,309...20,907,009
Ensembl chr17:20,887,309...20,907,083
JBrowse link
G Cd86 CD86 molecule multiple interactions
increases expression
ISO [Poly I-C co-treated with IFNG protein] results in increased secretion of CD86 protein; CEP-11004 inhibits the reaction [Poly I-C results in increased expression of CD86 protein]; Particulate Matter analog inhibits the reaction [Poly I-C results in increased expression of CD86 protein]; SB 203580 inhibits the reaction [Poly I-C results in increased expression of CD86 protein]; Vehicle Emissions analog inhibits the reaction [Poly I-C results in increased expression of CD86 protein] CTD PMID:15246609 PMID:16224278 PMID:16890772 PMID:17698565 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
JBrowse link
G Cdc42 cell division cycle 42 multiple interactions ISO [Poly I-C co-treated with Atorvastatin] results in decreased expression of CDC42 mRNA CTD PMID:34696514 NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111
JBrowse link
G Cdx2 caudal type homeo box 2 multiple interactions ISO [Poly I-C co-treated with 6-formylindolo(3,2-b)carbazole] results in increased expression of CDX2 mRNA; [Poly I-C co-treated with Tetrachlorodibenzodioxin] results in increased expression of CDX2 mRNA CTD PMID:27783115 NCBI chr12:7,726,798...7,733,142
Ensembl chr12:7,726,798...7,733,142
JBrowse link
G Celf1 CUGBP, Elav-like family member 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of CELF1 mRNA CTD PMID:26923065 NCBI chr 3:76,924,591...76,999,429
Ensembl chr 3:76,924,613...76,999,426
JBrowse link
G Cfp complement factor properdin multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of CFP mRNA CTD PMID:26923065 NCBI chr  X:1,162,014...1,167,576
Ensembl chr  X:1,161,979...1,167,573
JBrowse link
G Chsy1 chondroitin sulfate synthase 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of CHSY1 mRNA CTD PMID:26923065 NCBI chr 1:119,689,626...119,750,711
Ensembl chr 1:119,686,350...119,750,601
JBrowse link
G Cibar2 CBY1 interacting BAR domain containing 2 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of CIBAR2 mRNA CTD PMID:26923065 NCBI chr19:48,217,617...48,229,418
Ensembl chr19:48,215,486...48,229,404
JBrowse link
G Clcc1 chloride channel CLIC-like 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of CLCC1 mRNA CTD PMID:26923065 NCBI chr 2:196,296,350...196,326,914
Ensembl chr 2:196,296,393...196,326,913
JBrowse link
G Clec14a C-type lectin domain containing 14A multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of CLEC14A mRNA CTD PMID:26923065 NCBI chr 6:75,881,470...75,884,612
Ensembl chr 6:75,881,473...75,884,612
JBrowse link
G Clip3 CAP-GLY domain containing linker protein 3 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of CLIP3 mRNA CTD PMID:26923065 NCBI chr 1:85,547,170...85,563,187
Ensembl chr 1:85,547,206...85,563,184
JBrowse link
G Cnnm1 cyclin and CBS domain divalent metal cation transport mediator 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of CNNM1 mRNA CTD PMID:26923065 NCBI chr 1:242,296,367...242,354,957
Ensembl chr 1:242,296,422...242,353,513
JBrowse link
G Cnr1 cannabinoid receptor 1 multiple interactions EXP Cannabidiol inhibits the reaction [Poly I-C inhibits the reaction [Rimonabant binds to CNR1 protein]]; Poly I-C inhibits the reaction [Rimonabant binds to CNR1 protein] CTD PMID:31202911 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099
JBrowse link
G Cnr2 cannabinoid receptor 2 increases expression EXP Poly I-C results in increased expression of CNR2 mRNA CTD PMID:27317300 NCBI chr 5:148,125,222...148,151,548
Ensembl chr 5:148,125,604...148,151,548
JBrowse link
G Cntn1 contactin 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of CNTN1 mRNA CTD PMID:26923065 NCBI chr 7:123,263,146...123,560,896
Ensembl chr 7:123,372,792...123,558,541
JBrowse link
G Crabp1 cellular retinoic acid binding protein 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of CRABP1 mRNA CTD PMID:26923065 NCBI chr 8:55,138,363...55,159,360
Ensembl chr 8:55,151,285...55,159,360
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions
increases secretion
increases expression
ISO Ethanol inhibits the reaction [Poly I-C results in increased expression of CSF2 protein]
Poly I-C results in increased secretion of CSF2 protein
Smoke inhibits the reaction [Poly I-C results in increased secretion of CSF2 protein]
CTD PMID:19500611 PMID:35817128 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Cttnbp2 cortactin binding protein 2 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of CTTNBP2 mRNA CTD PMID:26923065 NCBI chr 4:46,800,975...46,964,681
Ensembl chr 4:46,800,981...46,964,631
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases expression EXP Poly I-C results in increased expression of CXCL1 mRNA CTD PMID:23939143 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions
increases secretion
increases expression
ISO
EXP
APPL1 protein promotes the reaction [Poly I-C results in increased expression of CXCL10 mRNA]; chrysin inhibits the reaction [Poly I-C results in increased expression of CXCL10 mRNA]; eriodictyol inhibits the reaction [Poly I-C results in increased expression of CXCL10 mRNA]; Luteolin inhibits the reaction [Poly I-C results in increased expression of CXCL10 mRNA]; Quercetin inhibits the reaction [Poly I-C results in increased expression of CXCL10 mRNA]; trametinib promotes the reaction [Poly I-C results in increased expression of CXCL10 mRNA]
Poly I-C results in increased secretion of CXCL10 protein
cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester inhibits the reaction [Poly I-C results in increased expression of CXCL10 mRNA]
Poly I-C results in increased expression of CXCL10 mRNA; Poly I-C results in increased expression of CXCL10 protein
[Dronabinol co-treated with Cannabidiol] inhibits the reaction [Poly I-C results in increased expression of CXCL10 protein]; [Pam(3)CSK(4) peptide co-treated with Antigens, Bacterial co-treated with Poly I-C co-treated with Lipopolysaccharides co-treated with FSL-1 lipoprotein, synthetic co-treated with Imiquimod co-treated with Polyribonucleotides co-treated with ProMune] results in increased expression of CXCL10 protein; bafilomycin A1 inhibits the reaction [Poly I-C results in increased expression of CXCL10 protein]; Cannabidiol inhibits the reaction [Poly I-C results in increased expression of CXCL10 mRNA]; Cannabidiol inhibits the reaction [Poly I-C results in increased expression of CXCL10 protein]; Cannabidiol inhibits the reaction [Poly I-C results in increased secretion of CXCL10 protein]; Chloroquine inhibits the reaction [Poly I-C results in increased expression of CXCL10 protein]; Dronabinol inhibits the reaction [Poly I-C results in increased expression of CXCL10 mRNA]; Dronabinol inhibits the reaction [Poly I-C results in increased expression of CXCL10 protein]; Particulate Matter inhibits the reaction [[Pam(3)CSK(4) peptide co-treated with Antigens, Bacterial co-treated with Poly I-C co-treated with Lipopolysaccharides co-treated with FSL-1 lipoprotein, synthetic co-treated with Imiquimod co-treated with Polyribonucleotides co-treated with ProMune] results in increased expression of CXCL10 protein]; Phosphorothioate Oligonucleotides inhibits the reaction [Poly I-C results in increased expression of CXCL10 protein]; Smoke inhibits the reaction [Poly I-C results in increased expression of CXCL10 protein]; Smoke inhibits the reaction [Poly I-C results in increased secretion of CXCL10 protein]; Vehicle Emissions inhibits the reaction [[Pam(3)CSK(4) peptide co-treated with Antigens, Bacterial co-treated with Poly I-C co-treated with Lipopolysaccharides co-treated with FSL-1 lipoprotein, synthetic co-treated with Imiquimod co-treated with Polyribonucleotides co-treated with ProMune] results in increased expression of CXCL10 protein]
CTD PMID:19426678 PMID:25780039 PMID:26682054 PMID:28003376 PMID:28572013 More... NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression EXP Poly I-C results in increased expression of CXCL2 mRNA CTD PMID:23939143 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions
increases expression
ISO Ethanol inhibits the reaction [Poly I-C results in increased expression of CXCL1 protein] CTD PMID:19500611 NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 multiple interactions
increases secretion
increases expression
ISO Luteolin inhibits the reaction [Poly I-C results in increased expression of CXCL9 mRNA]; methyldithiocarbamate inhibits the reaction [Poly I-C results in increased secretion of CXCL9 protein] CTD PMID:19426678 PMID:24056979 NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435
JBrowse link
G Cyfip2 cytoplasmic FMR1 interacting protein 2 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of CYFIP2 mRNA CTD PMID:26923065 NCBI chr10:30,621,318...30,741,113
Ensembl chr10:30,621,318...30,741,113
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO Poly I-C promotes the reaction [6-formylindolo(3,2-b)carbazole results in increased expression of CYP1A1 mRNA] CTD PMID:27783115 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases expression EXP Poly I-C results in decreased expression of CYP2C11 mRNA CTD PMID:23939143 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 decreases expression EXP Poly I-C results in decreased expression of CYP2C6 mRNA CTD PMID:23939143 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2c7 cytochrome P450, family 2, subfamily c, polypeptide 7 decreases expression EXP Poly I-C results in decreased expression of CYP2C7 mRNA CTD PMID:23939143 NCBI chr 1:237,332,641...237,388,714
Ensembl chr 1:237,332,659...237,388,709
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 decreases expression EXP Poly I-C results in decreased expression of CYP3A23-3A1 mRNA CTD PMID:23939143 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030
JBrowse link
G Cyria CYFIP related Rac1 interactor A multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of CYRIA mRNA CTD PMID:26923065 NCBI chr 6:35,045,208...35,150,669
Ensembl chr 6:35,045,208...35,150,668
JBrowse link
G Cysrt1 cysteine rich tail 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of CYSRT1 mRNA CTD PMID:26923065 NCBI chr 3:8,054,195...8,057,846
Ensembl chr 3:8,053,482...8,059,721
JBrowse link
G Dab1 DAB adaptor protein 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of DAB1 mRNA CTD PMID:26923065 NCBI chr 5:118,392,953...119,513,625
Ensembl chr 5:119,140,533...119,510,552
JBrowse link
G Dck deoxycytidine kinase multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of DCK mRNA CTD PMID:26923065 NCBI chr14:19,305,218...19,326,247
Ensembl chr14:19,305,218...19,326,247
JBrowse link
G Dcun1d3 defective in cullin neddylation 1 domain containing 3 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of DCUN1D3 mRNA CTD PMID:26923065 NCBI chr 1:174,243,001...174,285,647
Ensembl chr 1:66,494,848...66,496,343
Ensembl chr 1:66,494,848...66,496,343
JBrowse link
G Dcun1d4 defective in cullin neddylation 1 domain containing 4 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of DCUN1D4 mRNA CTD PMID:26923065 NCBI chr14:34,652,723...34,733,122
Ensembl chr14:34,652,723...34,733,207
JBrowse link
G Ddx3x DEAD-box helicase 3, X-linked multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of DDX3X mRNA CTD PMID:26923065 NCBI chr  X:9,479,532...9,493,169
Ensembl chr  X:9,479,532...9,493,168
JBrowse link
G Dlg1 discs large MAGUK scaffold protein 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of DLG1 mRNA CTD PMID:26923065 NCBI chr11:68,911,883...69,103,230
Ensembl chr11:68,911,883...69,102,689
JBrowse link
G Dnm2 dynamin 2 multiple interactions ISO DNM2 protein promotes the reaction [Poly I-C results in increased phosphorylation of IRF3 protein] CTD PMID:25780039 NCBI chr 8:19,978,313...20,060,162
Ensembl chr 8:19,978,400...20,060,157
JBrowse link
G Dnmt1 DNA methyltransferase 1 multiple interactions ISO [Arsenicals co-treated with Poly I-C co-treated with Alitretinoin] results in increased expression of DNMT1 mRNA; [Arsenicals co-treated with Poly I-C] results in increased expression of DNMT1 mRNA CTD PMID:34303791 NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659
JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha multiple interactions ISO [Arsenicals co-treated with Poly I-C co-treated with Alitretinoin] results in increased expression of DNMT3A mRNA; [Arsenicals co-treated with Poly I-C] results in increased expression of DNMT3A mRNA CTD PMID:34303791 NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687
JBrowse link
G Eea1 early endosome antigen 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of EEA1 mRNA CTD PMID:26923065 NCBI chr 7:30,554,686...30,722,186
Ensembl chr 7:30,554,552...30,718,487
JBrowse link
G Egr1 early growth response 1 multiple interactions
affects methylation
ISO
EXP
[Poly I-C results in increased susceptibility to 4-iodo-2,5-dimethoxyphenylisopropylamine] which results in increased expression of EGR1 mRNA; Poly I-C promotes the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of EGR1 mRNA]
Poly I-C affects the methylation of EGR1 promoter
CTD PMID:24889602 PMID:32843831 NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 increases expression
increases phosphorylation
increases response to substance
ISO Poly I-C results in increased expression of EIF2AK2 mRNA
Poly I-C results in increased phosphorylation of EIF2AK2 protein
EIF2AK2 results in increased susceptibility to Poly I-C
CTD PMID:10944112 PMID:17669408 PMID:22240577 PMID:22558189 NCBI chr 6:16,189,000...16,224,972
Ensembl chr 6:16,188,979...16,224,971
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation ISO Poly I-C results in increased phosphorylation of EIF2S1 protein CTD PMID:22240577 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
JBrowse link
G Epc2l1 enhancer of polycomb homolog 2 (Drosophila)-like 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of EPC2L1 mRNA CTD PMID:26923065 NCBI chr 1:81,931,963...81,934,681
Ensembl chr 1:81,932,016...81,934,442
JBrowse link
G F11r F11 receptor multiple interactions
decreases expression
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Poly I-C results in decreased expression of F11R protein]; CpG ODN 2006 inhibits the reaction [Poly I-C results in decreased expression of F11R protein]; N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide inhibits the reaction [Poly I-C results in decreased expression of F11R protein]; RTKI cpd inhibits the reaction [Poly I-C results in decreased expression of F11R protein]; SB 203580 inhibits the reaction [Poly I-C results in decreased expression of F11R protein] CTD PMID:20932985 NCBI chr13:83,873,797...83,897,388
Ensembl chr13:83,873,797...83,897,402
JBrowse link
G Fabp4 fatty acid binding protein 4 increases expression ISO Poly I-C results in increased expression of FABP4 mRNA CTD PMID:15705927 NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578
JBrowse link
G Fam107a family with sequence similarity 107, member A multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of FAM107A mRNA CTD PMID:26923065 NCBI chr15:16,608,362...16,630,398
Ensembl chr15:16,607,205...16,630,396
JBrowse link
G Fmr1 fragile X messenger ribonucleoprotein 1 multiple interactions
decreases expression
ISO Suramin inhibits the reaction [Poly I-C results in decreased expression of FMR1 protein] CTD PMID:23516405 NCBI chr  X:147,240,239...147,278,057
Ensembl chr  X:147,240,301...147,278,050
JBrowse link
G Fxyd3 FXYD domain-containing ion transport regulator 3 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of FXYD3 mRNA CTD PMID:26923065 NCBI chr 1:86,305,531...86,312,455 JBrowse link
G Fyttd1 forty-two-three domain containing 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of FYTTD1 mRNA CTD PMID:26923065 NCBI chr11:67,877,967...67,907,500
Ensembl chr11:67,877,967...67,907,511
JBrowse link
G G3bp1 G3BP stress granule assembly factor 1 affects localization ISO Poly I-C affects the localization of G3BP1 protein CTD PMID:22240577 NCBI chr10:39,586,864...39,620,268
Ensembl chr10:39,586,864...39,620,268
JBrowse link
G G3bp2 G3BP stress granule assembly factor 2 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of G3BP2 mRNA CTD PMID:26923065 NCBI chr14:15,932,403...16,020,555
Ensembl chr14:15,987,417...16,020,548
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of GABRA1 mRNA CTD PMID:26923065 NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864
JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of GABRB2 mRNA CTD PMID:26923065 NCBI chr10:26,936,592...27,156,141
Ensembl chr10:26,936,551...27,151,251
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of GABRG2 mRNA CTD PMID:26923065 NCBI chr10:26,374,693...26,463,937
Ensembl chr10:26,374,694...26,464,346
JBrowse link
G Gad1 glutamate decarboxylase 1 decreases expression
multiple interactions
EXP Poly I-C results in decreased expression of GAD1 protein
Cannabidiol inhibits the reaction [Poly I-C results in decreased expression of GAD1 protein]
CTD PMID:31202911 NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333
JBrowse link
G Gdap1 ganglioside-induced differentiation-associated-protein 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of GDAP1 mRNA CTD PMID:26923065 NCBI chr 5:1,932,613...1,951,691
Ensembl chr 5:1,932,613...2,030,061
JBrowse link
G Gdi1 GDP dissociation inhibitor 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of GDI1 mRNA CTD PMID:26923065 NCBI chr  X:152,087,611...152,094,274
Ensembl chr  X:152,087,444...152,094,272
JBrowse link
G Get3 guided entry of tail-anchored proteins factor 3, ATPase multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of GET3 mRNA CTD PMID:26923065 NCBI chr19:23,130,109...23,138,196
Ensembl chr19:23,130,109...23,138,193
JBrowse link
G Gfap glial fibrillary acidic protein increases expression EXP Poly I-C results in increased expression of GFAP mRNA CTD PMID:27317300 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
JBrowse link
G Gh1 growth hormone 1 decreases expression ISO Poly I-C results in decreased expression of GH protein CTD PMID:21195166 NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078
JBrowse link
G Glce glucuronic acid epimerase multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of GLCE mRNA CTD PMID:26923065 NCBI chr 8:62,546,104...62,612,144
Ensembl chr 8:62,546,107...62,612,040
JBrowse link
G Glrb glycine receptor, beta multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of GLRB mRNA CTD PMID:26923065 NCBI chr 2:166,134,616...166,207,498
Ensembl chr 2:166,134,626...166,207,489
JBrowse link
G Glyr1 glyoxylate reductase 1 homolog multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of GLYR1 mRNA CTD PMID:26923065 NCBI chr10:10,532,036...10,567,639
Ensembl chr10:10,532,154...10,567,637
JBrowse link
G Gmfb glia maturation factor, beta multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of GMFB mRNA CTD PMID:26923065 NCBI chr15:20,069,923...20,081,005
Ensembl chr15:20,067,263...20,080,331
JBrowse link
G Gmppb GDP-mannose pyrophosphorylase B multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of GMPPB mRNA CTD PMID:26923065 NCBI chr 8:108,737,429...108,740,437
Ensembl chr 8:108,693,060...108,767,286
JBrowse link
G Gpatch2l G patch domain containing 2-like multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of GPATCH2L mRNA CTD PMID:26923065 NCBI chr 6:105,883,383...105,935,644
Ensembl chr 6:105,883,460...105,934,888
JBrowse link
G Gpbp1 GC-rich promoter binding protein 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of GPBP1 mRNA CTD PMID:26923065 NCBI chr 2:43,023,504...43,091,146
Ensembl chr 2:43,023,504...43,090,907
JBrowse link
G Gsr glutathione-disulfide reductase decreases expression EXP Poly I-C results in decreased expression of GSR mRNA CTD PMID:23939143 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Gzmb granzyme B multiple interactions
increases expression
ISO Particulate Matter inhibits the reaction [Poly I-C results in increased expression of GZMB mRNA]; Particulate Matter inhibits the reaction [Poly I-C results in increased expression of GZMB protein]; Vehicle Emissions inhibits the reaction [Poly I-C results in increased expression of GZMB mRNA]; Vehicle Emissions inhibits the reaction [Poly I-C results in increased expression of GZMB protein]
Poly I-C results in increased expression of GZMB mRNA; Poly I-C results in increased expression of GZMB protein
CTD PMID:23618096 NCBI chr15:30,343,352...30,346,814
Ensembl chr15:30,173,603...30,346,814
JBrowse link
G Hey2 hes-related family bHLH transcription factor with YRPW motif 2 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of HEY2 mRNA CTD PMID:26923065 NCBI chr 1:26,822,131...26,832,218
Ensembl chr 1:26,822,131...26,832,218
JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions ISO Indoprofen inhibits the reaction [Poly I-C results in increased secretion of and affects the localization of HMGB1 protein]; Poly I-C results in increased secretion of and affects the localization of HMGB1 protein CTD PMID:34755645 NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
EXP Diclofenac promotes the reaction [Poly I-C results in increased expression of HMOX1 mRNA] CTD PMID:23939143 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 increases expression EXP Poly I-C results in increased expression of HSP90AA1 mRNA CTD PMID:23939143 NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression EXP Poly I-C results in increased expression of HSPA1A mRNA CTD PMID:23939143 NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 increases expression EXP Poly I-C results in increased expression of HSPA8 mRNA CTD PMID:23939143 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A increases expression ISO Poly I-C results in increased expression of HTR2A mRNA CTD PMID:24889602 NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928
JBrowse link
G Ibtk inhibitor of Bruton tyrosine kinase multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of IBTK mRNA CTD PMID:26923065 NCBI chr 8:86,625,591...86,698,661
Ensembl chr 8:86,625,597...86,698,260
JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 increases expression
multiple interactions
ISO Poly I-C results in increased expression of IDO1 mRNA
poly(I:C) co-treated with tryptophan or alone increases activity and expression of IDO1 protein in Langerhans cell-like dendritic cells
CTD
RGD
PMID:27783115 PMID:26198597 RGD:11528429 NCBI chr16:67,430,654...67,442,726
Ensembl chr16:67,430,578...67,442,730
JBrowse link
G Ido2 indoleamine 2,3-dioxygenase 2 increases expression ISO Poly I-C results in increased expression of IDO2 mRNA CTD PMID:27783115 NCBI chr16:67,459,158...67,498,052
Ensembl chr16:67,459,190...67,496,324
JBrowse link
G Ifih1 interferon induced with helicase C domain 1 increases expression
multiple interactions
ISO Poly I-C results in increased expression of IFIH1 mRNA
IRF7 protein mutant form inhibits the reaction [Poly I-C results in increased expression of IFIH1 mRNA]; Nicotine inhibits the reaction [Poly I-C results in increased expression of IFIH1 mRNA]
CTD PMID:30341573 PMID:31154625 NCBI chr 3:47,228,980...47,275,403
Ensembl chr 3:47,227,364...47,275,456
JBrowse link
G Ifit2 interferon-induced protein with tetratricopeptide repeats 2 multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [Dieldrin inhibits the reaction [Poly I-C results in increased expression of IFIT2 mRNA]]; Dieldrin inhibits the reaction [Poly I-C results in increased expression of IFIT2 mRNA] CTD PMID:34051100 NCBI chr 1:232,102,570...232,108,638
Ensembl chr 1:232,102,570...232,108,635
JBrowse link
G Ifitm1 interferon induced transmembrane protein 1 increases expression ISO Poly I-C results in increased expression of IFITM1 mRNA CTD PMID:22240577 NCBI chr 1:196,067,163...196,069,169
Ensembl chr 1:196,067,963...196,069,169
JBrowse link
G Ifna1 interferon, alpha 1 increases expression EXP Poly I-C results in increased expression of IFNA1 mRNA CTD PMID:28726298 NCBI chr 5:103,097,356...103,097,925
Ensembl chr 5:103,097,356...103,097,925
JBrowse link
G Ifnb1 interferon beta 1 increases expression
increases secretion
multiple interactions
ISO
EXP
Poly I-C results in increased expression of IFNB1 mRNA; Poly I-C results in increased expression of IFNB1 protein
Poly I-C results in increased secretion of IFNB1 protein
MIR26A mRNA inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]
apilimod inhibits the reaction [Poly I-C results in increased secretion of IFNB1 protein]; APPL1 protein promotes the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; BX795 inhibits the reaction [Poly I-C results in increased expression of IFNB1 protein]; Luteolin inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; pitavastatin inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; Pravastatin inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; Progesterone inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; Resveratrol inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; sodium arsenite inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; sodium arsenite inhibits the reaction [Poly I-C results in increased secretion of IFNB1 protein]; Sodium Selenite inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; trametinib promotes the reaction [Poly I-C results in increased expression of IFNB1 mRNA]
[Dronabinol co-treated with Cannabidiol] inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; [Vehicle Emissions analog co-treated with Poly I-C] results in increased expression of IFNB1 mRNA; Cannabidiol inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; Dronabinol inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; IRF7 protein affects the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; IRF7 protein mutant form affects the reaction [Nicotine inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]]; IRF7 protein mutant form inhibits the reaction [Nicotine inhibits the reaction [Poly I-C results in increased secretion of IFNB1 protein]]; IRF7 protein mutant form inhibits the reaction [Poly I-C results in increased secretion of IFNB1 protein]; Nicotine inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; Nicotine inhibits the reaction [Poly I-C results in increased secretion of IFNB1 protein]; Smoke inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; TLR3 protein affects the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; TP53 protein affects the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; Wortmannin inhibits the reaction [[Vehicle Emissions analog co-treated with Poly I-C] results in increased expression of IFNB1 mRNA]
CTD PMID:16116226 PMID:16399790 PMID:17669408 PMID:18279804 PMID:18323514 More... NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523
JBrowse link
G Ifng interferon gamma multiple interactions
increases secretion
increases expression
ISO
EXP
[Poly I-C co-treated with IFNG protein] results in increased secretion of CD40 protein; [Poly I-C co-treated with IFNG protein] results in increased secretion of CD86 protein; Smoke inhibits the reaction [Poly I-C results in increased expression of IFNG mRNA]
Poly I-C results in increased secretion of IFNG protein
Ethanol inhibits the reaction [Poly I-C results in increased expression of IFNG protein]
Poly I-C results in increased expression of IFNG mRNA; Poly I-C results in increased expression of IFNG protein
CTD PMID:9328138 PMID:16224278 PMID:17321468 PMID:19500611 PMID:23618096 More... NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Ifnl1 interferon, lambda 1 increases expression
multiple interactions
ISO Poly I-C results in increased expression of IFNL1 mRNA
Smoke inhibits the reaction [Poly I-C results in increased expression of IFNL1 mRNA]
CTD PMID:35817128 NCBI chr 1:83,798,651...83,800,297
Ensembl chr 1:83,798,703...83,800,235
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions
decreases expression
ISO IL6 protein affects the reaction [Poly I-C results in decreased expression of IGF1 protein]
Poly I-C results in decreased expression of IGF1 mRNA; Poly I-C results in decreased expression of IGF1 protein
CTD PMID:1705203 PMID:21195166 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 multiple interactions
decreases expression
ISO IL6 protein affects the reaction [Poly I-C results in decreased expression of IGFBP3 protein] CTD PMID:21195166 NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083
JBrowse link
G Igsf6 immunoglobulin superfamily, member 6 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of IGSF6 mRNA CTD PMID:26923065 NCBI chr 1:175,610,167...175,620,662
Ensembl chr 1:175,610,167...175,620,722
JBrowse link
G Ikbke inhibitor of nuclear factor kappa B kinase subunit epsilon multiple interactions
increases phosphorylation
ISO APPL1 protein promotes the reaction [Poly I-C results in increased phosphorylation of IKBKE protein] CTD PMID:25780039 NCBI chr13:42,712,154...42,738,470
Ensembl chr13:42,712,159...42,737,143
JBrowse link
G Il10 interleukin 10 multiple interactions
increases expression
increases secretion
ISO
EXP
CEP-11004 inhibits the reaction [Poly I-C results in increased secretion of IL10 protein]; SB 203580 inhibits the reaction [Poly I-C results in increased secretion of IL10 protein]
Poly I-C results in increased expression of IL10 mRNA
Poly I-C results in increased expression of IL10 mRNA; Poly I-C results in increased expression of IL10 protein
Citrinin inhibits the reaction [Poly I-C results in increased expression of IL10 mRNA]; Citrinin inhibits the reaction [Poly I-C results in increased expression of IL10 protein]
CTD PMID:16224278 PMID:17698565 PMID:22771370 PMID:23618096 PMID:23939143 More... NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il12a interleukin 12A multiple interactions
increases expression
ISO 6-formylindolo(3,2-b)carbazole inhibits the reaction [Poly I-C results in increased expression of IL12A mRNA]; indole-3-carbinol inhibits the reaction [Poly I-C results in increased expression of IL12A mRNA]; Tetrachlorodibenzodioxin inhibits the reaction [Poly I-C results in increased expression of IL12A mRNA] CTD PMID:27783115 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734
JBrowse link
G Il12b interleukin 12B multiple interactions
increases expression
ISO [[Poly I-C binds to and results in increased activity of TLR3 protein] which co-treated with Nanotubes, Carbon] results in increased secretion of IL12B protein; Particulate Matter analog inhibits the reaction [Poly I-C results in increased expression of IL12B protein]; Vehicle Emissions analog inhibits the reaction [Poly I-C results in increased expression of IL12B protein]
Poly I-C results in increased expression of IL12B mRNA; Poly I-C results in increased expression of IL12B protein
Ethanol inhibits the reaction [Poly I-C results in increased expression of IL12B protein]; Luteolin inhibits the reaction [Poly I-C results in increased expression of IL12B mRNA]
CTD PMID:16890772 PMID:19426678 PMID:19500611 PMID:23266719 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Il17a interleukin 17A increases expression ISO Poly I-C results in increased expression of IL17A protein CTD PMID:30836164 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases secretion
increases expression
ISO
EXP
APPL1 protein inhibits the reaction [Poly I-C results in increased expression of IL1B protein]; Citrinin inhibits the reaction [Poly I-C results in increased expression of IL1B mRNA]; Ethanol inhibits the reaction [Poly I-C results in increased expression of IL1B protein]; Poly I-C promotes the reaction [deoxynivalenol results in increased expression of IL1B mRNA]
Poly I-C results in increased secretion of IL1B protein
2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane promotes the reaction [Poly I-C results in increased expression of IL1B protein]; 4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol promotes the reaction [Poly I-C results in increased expression of IL1B protein]; 6-formylindolo(3,2-b)carbazole promotes the reaction [Poly I-C results in increased expression of IL1B mRNA]; Estradiol promotes the reaction [Poly I-C results in increased expression of IL1B protein]; Tetrachlorodibenzodioxin promotes the reaction [Poly I-C results in increased expression of IL1B mRNA]
Poly I-C results in increased expression of IL1B mRNA; Poly I-C results in increased expression of IL1B protein
CTD PMID:16687389 PMID:17321468 PMID:19500611 PMID:22771370 PMID:23618096 More... NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il2 interleukin 2 increases expression
increases secretion
ISO Poly I-C results in increased expression of IL2 mRNA
Poly I-C results in increased secretion of IL2 protein
CTD PMID:9328138 PMID:23618096 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il27 interleukin 27 increases expression
multiple interactions
ISO Poly I-C results in increased expression of IL27 mRNA
Luteolin inhibits the reaction [Poly I-C results in increased expression of IL27 mRNA]
CTD PMID:19426678 NCBI chr 1:181,173,108...181,178,720
Ensembl chr 1:181,173,372...181,178,582
JBrowse link
G Il33 interleukin 33 increases expression
multiple interactions
ISO Poly I-C results in increased expression of IL33 protein
N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Poly I-C results in increased expression of IL33 protein]
2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane promotes the reaction [Poly I-C results in increased expression of IL33 protein]; 4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol promotes the reaction [Poly I-C results in increased expression of IL33 protein]; Estradiol promotes the reaction [Poly I-C results in increased expression of IL33 protein]
CTD PMID:25747661 PMID:30017638 NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373
JBrowse link
G Il4 interleukin 4 multiple interactions
increases expression
increases secretion
increases response to substance
ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; 4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol promotes the reaction [Poly I-C results in increased expression of IL4 protein]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; [Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2; [Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2; [Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein; [Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA; [Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA; [Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA; [Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein; [Poly I-C co-treated with IL4 protein] results in increased secretion of Dinoprost; [Poly I-C co-treated with IL4 protein] results in increased secretion of Dinoprostone; [Poly I-C co-treated with IL4 protein] results in increased secretion of Thromboxane B2; amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]; amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]; amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Thromboxane B2]; amorolfine promotes the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Dinoprostone]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Thromboxane B2]; butenafine promotes the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Dinoprostone]; Estradiol promotes the reaction [Poly I-C results in increased expression of IL4 protein]; helenalin inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; helenalin inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; helenalin inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; helenalin inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; IL4 protein promotes the reaction [Poly I-C results in increased expression of CCL5 mRNA]; IL4 protein promotes the reaction [Poly I-C results in increased expression of CXCL8 mRNA]; IL4 protein promotes the reaction [Poly I-C results in increased expression of TSLP mRNA]; IL4 protein promotes the reaction [Poly I-C results in increased expression of TSLP protein]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Thromboxane B2]; Itraconazole promotes the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Dinoprostone]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Thromboxane B2]; Ketoconazole promotes the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Dinoprostone]; luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]; luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]; luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Thromboxane B2]; luliconazole promotes the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Dinoprostone]; Particulate Matter inhibits the reaction [Poly I-C results in increased secretion of IL4 protein]; Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]; Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]; Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Thromboxane B2]; Terbinafine promotes the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Dinoprostone]; Vehicle Emissions inhibits the reaction [Poly I-C results in increased secretion of IL4 protein]
IL4 protein results in increased susceptibility to Poly I-C
CTD PMID:23618096 PMID:23688403 PMID:30017638 PMID:30836164 PMID:34740670 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il6 interleukin 6 multiple interactions
increases secretion
increases expression
ISO
EXP
[Vehicle Emissions analog co-treated with Poly I-C] results in increased secretion of IL6 protein; CEP-11004 inhibits the reaction [Poly I-C results in increased secretion of IL6 protein]; Particulate Matter promotes the reaction [Poly I-C results in increased expression of IL6]; SB 203580 inhibits the reaction [Poly I-C results in increased secretion of IL6 protein]; Smoke inhibits the reaction [Poly I-C results in increased secretion of IL6 protein]; TLR3 mRNA promotes the reaction [Poly I-C results in increased expression of IL6 mRNA]; TRAF6 mutant form inhibits the reaction [Vehicle Emissions analog promotes the reaction [Poly I-C results in increased expression of IL6 mRNA]]; Vehicle Emissions analog promotes the reaction [Poly I-C results in increased expression of IL6 mRNA]; Vehicle Emissions promotes the reaction [Poly I-C results in increased expression of IL6]
Poly I-C results in increased expression of IL6 mRNA; Poly I-C results in increased expression of IL6 protein
Ethanol inhibits the reaction [Poly I-C results in increased expression of IL6 protein]; IL6 protein affects the reaction [Poly I-C results in decreased expression of IGF1 protein]; IL6 protein affects the reaction [Poly I-C results in decreased expression of IGFBP3 protein]; IL6 protein affects the reaction [Poly I-C results in increased expression of PRL2B1 mRNA]; IL6 protein affects the reaction [Poly I-C results in increased phosphorylation of and results in increased activity of STAT3 protein]; Luteolin inhibits the reaction [Poly I-C results in increased expression of IL6 mRNA]; pitavastatin inhibits the reaction [Poly I-C results in increased expression of IL6 mRNA]; Poly I-C promotes the reaction [deoxynivalenol results in increased expression of IL6 mRNA]; Pravastatin inhibits the reaction [Poly I-C results in increased expression of IL6 mRNA]; sodium arsenite inhibits the reaction [Poly I-C results in increased expression of IL6 mRNA]
Poly I-C results in increased expression of IL6; Poly I-C results in increased expression of IL6 mRNA
CTD PMID:9328138 PMID:16399790 PMID:16687389 PMID:17698565 PMID:18323514 More... NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Irf3 interferon regulatory factor 3 increases phosphorylation
affects localization
multiple interactions
ISO Poly I-C results in increased phosphorylation of IRF3 protein
Poly I-C affects the localization of IRF3 protein
APPL1 protein promotes the reaction [Poly I-C results in increased phosphorylation of IRF3 protein]; BX795 inhibits the reaction [Poly I-C results in increased phosphorylation of IRF3 protein]; Chloroquine inhibits the reaction [Poly I-C results in increased phosphorylation of IRF3 protein]; chrysin inhibits the reaction [Poly I-C results in increased expression of IRF3 mRNA]; DNM2 protein promotes the reaction [Poly I-C results in increased phosphorylation of IRF3 protein]; eriodictyol inhibits the reaction [Poly I-C results in increased expression of IRF3 mRNA]; Quercetin inhibits the reaction [Poly I-C results in increased expression of IRF3 mRNA]; Sodium Selenite inhibits the reaction [Poly I-C results in increased activity of IRF3 protein]
[Dronabinol co-treated with Cannabidiol] inhibits the reaction [Poly I-C affects the localization of IRF3 protein]; [Vehicle Emissions analog co-treated with Poly I-C] affects the localization of IRF3 protein; Cannabidiol inhibits the reaction [Poly I-C affects the localization of IRF3 protein]; Dronabinol inhibits the reaction [Poly I-C results in increased localization of IRF3 protein]; TP53 protein affects the reaction [Poly I-C results in increased phosphorylation of IRF3 protein]
CTD PMID:16399790 PMID:18279804 PMID:18779317 PMID:19426678 PMID:25780039 More... NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:95,479,821...95,484,935
JBrowse link
G Irf7 interferon regulatory factor 7 multiple interactions
increases expression
ISO
EXP
IRF7 protein affects the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; IRF7 protein mutant form affects the reaction [Nicotine inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]]; IRF7 protein mutant form inhibits the reaction [Nicotine inhibits the reaction [Poly I-C results in increased secretion of IFNB1 protein]]; IRF7 protein mutant form inhibits the reaction [Poly I-C results in increased expression of IFIH1 mRNA]; IRF7 protein mutant form inhibits the reaction [Poly I-C results in increased expression of IFIT1 mRNA]; IRF7 protein mutant form inhibits the reaction [Poly I-C results in increased expression of IRF7 mRNA]; IRF7 protein mutant form inhibits the reaction [Poly I-C results in increased expression of IRF9 mRNA]; IRF7 protein mutant form inhibits the reaction [Poly I-C results in increased expression of ISG15 mRNA]; IRF7 protein mutant form inhibits the reaction [Poly I-C results in increased expression of OAS1 mRNA]; IRF7 protein mutant form inhibits the reaction [Poly I-C results in increased expression of RIGI mRNA]; IRF7 protein mutant form inhibits the reaction [Poly I-C results in increased expression of STAT1 mRNA]; IRF7 protein mutant form inhibits the reaction [Poly I-C results in increased expression of STAT2 mRNA]; IRF7 protein mutant form inhibits the reaction [Poly I-C results in increased secretion of IFNB1 protein]; Nicotine inhibits the reaction [Poly I-C results in increased expression of IRF7 mRNA]
cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester inhibits the reaction [Poly I-C results in increased expression of IRF7 mRNA]
CTD PMID:22240577 PMID:28726298 PMID:31154625 NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832
JBrowse link
G Irf9 interferon regulatory factor 9 multiple interactions
increases expression
ISO IRF7 protein mutant form inhibits the reaction [Poly I-C results in increased expression of IRF9 mRNA] CTD PMID:22240577 PMID:31154625 NCBI chr15:29,095,474...29,101,924
Ensembl chr15:29,095,789...29,101,236
JBrowse link
G Isg15 ISG15 ubiquitin-like modifier increases expression
multiple interactions
ISO Poly I-C results in increased expression of ISG15 mRNA
IRF7 protein mutant form inhibits the reaction [Poly I-C results in increased expression of ISG15 mRNA]; Nicotine inhibits the reaction [Poly I-C results in increased expression of ISG15 mRNA]
CTD PMID:31154625 PMID:36958387 NCBI chr 5:166,784,148...166,785,435
Ensembl chr 5:166,784,148...166,785,435
JBrowse link
G Itgam integrin subunit alpha M increases expression EXP Poly I-C results in increased expression of ITGAM mRNA; Poly I-C results in increased expression of ITGAM protein CTD PMID:27317300 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503
JBrowse link
G Jcad junctional cadherin 5 associated multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of JCAD mRNA CTD PMID:26923065 NCBI chr17:53,089,382...53,130,996
Ensembl chr17:53,089,382...53,130,967
JBrowse link
G Kcna2 potassium voltage-gated channel subfamily A member 2 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of KCNA2 mRNA CTD PMID:26923065 NCBI chr 2:194,704,555...194,718,387
Ensembl chr 2:194,704,639...194,718,400
JBrowse link
G Kcnip4 potassium voltage-gated channel interacting protein 4 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of KCNIP4 mRNA CTD PMID:26923065 NCBI chr14:61,380,699...62,531,399
Ensembl chr14:61,381,076...62,530,144
JBrowse link
G Kcnq5 potassium voltage-gated channel subfamily Q member 5 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of KCNQ5 mRNA CTD PMID:26923065 NCBI chr 9:23,830,185...24,395,984
Ensembl chr 9:23,833,087...24,394,704
JBrowse link
G Kif5b kinesin family member 5B multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of KIF5B mRNA CTD PMID:26923065 NCBI chr17:51,489,904...51,527,508
Ensembl chr17:51,489,944...51,527,508
JBrowse link
G Kif5c kinesin family member 5C multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of KIF5C mRNA CTD PMID:26923065 NCBI chr 3:34,032,082...34,185,597
Ensembl chr 3:34,032,105...34,182,413
JBrowse link
G Klf4 KLF transcription factor 4 increases expression
multiple interactions
ISO Poly I-C results in increased expression of KLF4 protein
Poly I-C promotes the reaction [MSI1 protein results in increased expression of KLF4 protein]
CTD PMID:29486283 NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602
JBrowse link
G Klrk1 killer cell lectin like receptor K1 increases expression ISO Poly I-C results in increased expression of KLRK1 mRNA; Poly I-C results in increased expression of KLRK1 protein CTD PMID:16472598 NCBI chr 4:163,079,887...163,092,434
Ensembl chr 4:163,081,927...163,092,459
JBrowse link
G Kpna3 karyopherin subunit alpha 3 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of KPNA3 mRNA CTD PMID:26923065 NCBI chr15:35,536,310...35,610,066
Ensembl chr15:35,536,316...35,610,419
JBrowse link
G Kpna7 karyopherin subunit alpha 7 multiple interactions
increases expression
ISO Atorvastatin inhibits the reaction [Poly I-C results in increased expression of KPNA7 mRNA]; Ivermectin inhibits the reaction [Poly I-C results in increased expression of KPNA7 mRNA] CTD PMID:34696514 NCBI chr12:9,576,378...9,635,247
Ensembl chr12:9,576,378...9,612,833
JBrowse link
G Lsm14b LSM family member 14B multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of LSM14B mRNA CTD PMID:26923065 NCBI chr 3:167,125,633...167,136,417
Ensembl chr 3:167,125,628...167,136,432
JBrowse link
G Mal2 mal, T-cell differentiation protein 2 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of MAL2 mRNA CTD PMID:26923065 NCBI chr 7:85,900,453...85,933,433
Ensembl chr 7:85,900,453...85,933,429
JBrowse link
G Map3k11 mitogen-activated protein kinase kinase kinase 11 increases phosphorylation ISO Poly I-C results in increased phosphorylation of MAP3K11 protein CTD PMID:17698565 NCBI chr 1:202,975,353...202,988,655
Ensembl chr 1:202,975,353...202,988,652
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation
increases phosphorylation
multiple interactions
ISO Poly I-C results in decreased phosphorylation of MAPK1 protein
Poly I-C results in increased phosphorylation of MAPK1 protein
Suramin inhibits the reaction [Poly I-C results in decreased phosphorylation of MAPK1 protein]; trametinib inhibits the reaction [Poly I-C results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Poly I-C results in increased phosphorylation of MAPK1 protein]
CTD PMID:23516405 PMID:25780039 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation
increases phosphorylation
multiple interactions
ISO Poly I-C results in decreased phosphorylation of MAPK3 protein
Poly I-C results in increased phosphorylation of MAPK3 protein
Suramin inhibits the reaction [Poly I-C results in decreased phosphorylation of MAPK3 protein]; trametinib inhibits the reaction [Poly I-C results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Poly I-C results in increased phosphorylation of MAPK3 protein]
CTD PMID:23516405 PMID:25780039 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk4 mitogen-activated protein kinase 4 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of MAPK4 mRNA CTD PMID:26923065 NCBI chr18:67,512,805...67,661,271
Ensembl chr18:67,512,807...67,661,842
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of MAPK9 mRNA CTD PMID:26923065 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Mapre1 microtubule-associated protein, RP/EB family, member 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of MAPRE1 mRNA CTD PMID:26923065 NCBI chr 3:142,218,846...142,246,990
Ensembl chr 3:142,212,955...142,246,983
JBrowse link
G Marchf7 membrane associated ring-CH-type finger 7 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of MARCHF7 mRNA CTD PMID:26923065 NCBI chr 3:44,680,229...44,720,172
Ensembl chr 3:44,681,632...44,720,168
JBrowse link
G Mblac2 metallo-beta-lactamase domain containing 2 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of MBLAC2 mRNA CTD PMID:26923065 NCBI chr 2:11,986,075...12,028,882
Ensembl chr 2:11,986,027...12,030,950
JBrowse link
G Mbp myelin basic protein multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of MBP mRNA CTD PMID:26923065 NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404
JBrowse link
G Mef2c myocyte enhancer factor 2C multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of MEF2C mRNA CTD PMID:26923065 NCBI chr 2:13,973,299...14,136,065
Ensembl chr 2:13,993,438...14,132,880
JBrowse link
G Micos13 mitochondrial contact site and cristae organizing system subunit 13 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of MICOS13 mRNA CTD PMID:26923065 NCBI chr 9:1,439,841...1,441,782
Ensembl chr 9:1,439,058...1,442,076
JBrowse link
G Micu3 mitochondrial calcium uptake family, member 3 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of MICU3 mRNA CTD PMID:26923065 NCBI chr16:51,919,859...52,010,705
Ensembl chr16:51,925,225...52,010,613
JBrowse link
G Mir148b microRNA 148b multiple interactions ISO [Arsenicals co-treated with Poly I-C] results in decreased expression of MIR148B mRNA CTD PMID:34303791 NCBI chr 7:134,421,398...134,421,494
Ensembl chr 7:134,421,398...134,421,494
JBrowse link
G Mir152 microRNA 152 multiple interactions ISO [Arsenicals co-treated with Poly I-C co-treated with Alitretinoin] results in decreased expression of MIR152 mRNA; [Arsenicals co-treated with Poly I-C] results in decreased expression of MIR152 mRNA CTD PMID:34303791 NCBI chr10:81,832,936...81,833,020
Ensembl chr10:81,832,936...81,833,020
JBrowse link
G Mir155 microRNA 155 multiple interactions
increases expression
ISO MIR155 mRNA inhibits the reaction [Progesterone inhibits the reaction [Poly I-C results in increased expression of MIR155 mRNA]]; Progesterone inhibits the reaction [Poly I-C results in increased expression of MIR155 mRNA] CTD PMID:22546503 NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718
JBrowse link
G Mir26a microRNA 26a multiple interactions EXP MIR26A mRNA inhibits the reaction [Poly I-C results in increased activity of TLR3 protein]; MIR26A mRNA inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; MIR26A mRNA inhibits the reaction [Poly I-C results in increased expression of TNF mRNA]; MIR26A mRNA inhibits the reaction [Poly I-C results in increased expression of TNF protein] CTD PMID:24423102 NCBI chr 8:118,755,289...118,755,378
Ensembl chr 8:118,755,289...118,755,378
JBrowse link
G Mrps15 mitochondrial ribosomal protein S15 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of MRPS15 mRNA CTD PMID:26923065 NCBI chr 5:138,321,610...138,332,205
Ensembl chr 5:138,321,593...138,332,205
JBrowse link
G Msi1 musashi RNA-binding protein 1 multiple interactions ISO Poly I-C promotes the reaction [MSI1 protein results in increased expression of KLF4 protein]; Poly I-C promotes the reaction [MSI1 protein results in increased expression of MYC protein]; Poly I-C promotes the reaction [MSI1 protein results in increased expression of POU5F1 protein]; Poly I-C promotes the reaction [MSI1 protein results in increased expression of SOX2 protein] CTD PMID:29486283 NCBI chr12:41,158,301...41,251,134
Ensembl chr12:41,158,599...41,191,076
JBrowse link
G Mtpn myotrophin multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of MTPN mRNA CTD PMID:26923065 NCBI chr 4:64,159,273...64,186,686
Ensembl chr 4:64,157,641...64,186,724
JBrowse link
G Mtrex Mtr4 exosome RNA helicase multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of MTREX mRNA CTD PMID:26923065 NCBI chr 2:44,500,326...44,560,624
Ensembl chr 2:44,461,444...44,560,627
JBrowse link
G Mx1 MX dynamin like GTPase 1 increases expression
multiple interactions
ISO Poly I-C results in increased expression of MX1 mRNA
Acetylcysteine inhibits the reaction [Dieldrin inhibits the reaction [Poly I-C results in increased expression of MX1 mRNA]]; Dieldrin inhibits the reaction [Poly I-C results in increased expression of MX1 mRNA]
CTD PMID:17669408 PMID:22558189 PMID:34051100 NCBI chr11:36,799,659...36,825,209
Ensembl chr11:36,799,660...36,823,507
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
increases expression
ISO Poly I-C promotes the reaction [MSI1 protein results in increased expression of MYC protein]
Poly I-C results in increased expression of MYC protein
CTD PMID:29486283 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor increases expression
multiple interactions
ISO Poly I-C results in increased expression of MYD88 mRNA
cinnamaldehyde inhibits the reaction [Poly I-C results in increased expression of MYD88 mRNA]
CTD PMID:18306459 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
JBrowse link
G Naa60 N(alpha)-acetyltransferase 60, NatF catalytic subunit multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of NAA60 mRNA CTD PMID:26923065 NCBI chr10:11,622,554...11,653,078
Ensembl chr10:11,587,916...11,642,755
JBrowse link
G Napb NSF attachment protein beta multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of NAPB mRNA CTD PMID:26923065 NCBI chr 3:136,132,248...136,179,280
Ensembl chr 3:136,133,428...136,179,345
JBrowse link
G Napepld N-acyl phosphatidylethanolamine phospholipase D multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of NAPEPLD mRNA CTD PMID:26923065 NCBI chr 4:13,360,532...13,398,815
Ensembl chr 4:13,361,006...13,398,748
JBrowse link
G Nbea neurobeachin multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of NBEA mRNA CTD PMID:26923065 NCBI chr 2:139,780,021...140,338,639
Ensembl chr 2:139,780,021...140,340,584
JBrowse link
G Ndst3 N-deacetylase and N-sulfotransferase 3 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of NDST3 mRNA CTD PMID:26923065 NCBI chr 2:211,702,728...211,868,159
Ensembl chr 2:211,704,898...211,854,584
JBrowse link
G Necab1 N-terminal EF-hand calcium binding protein 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of NECAB1 mRNA CTD PMID:26923065 NCBI chr 5:28,357,859...28,578,642
Ensembl chr 5:28,357,859...28,578,642
Ensembl chr 5:28,357,859...28,578,642
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 increases expression
multiple interactions
ISO Poly I-C results in increased expression of NFKB1 mRNA
[Ivermectin co-treated with Atorvastatin] inhibits the reaction [Poly I-C results in increased expression of NFKB1 mRNA]; Atorvastatin inhibits the reaction [Poly I-C results in increased expression of NFKB1 mRNA]; Ivermectin inhibits the reaction [Poly I-C results in increased expression of NFKB1 mRNA]
CTD PMID:34696514 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkbia NFKB inhibitor alpha increases phosphorylation
multiple interactions
ISO Poly I-C results in increased phosphorylation of NFKBIA protein
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; [Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein; amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide inhibits the reaction [Poly I-C results in increased phosphorylation of NFKBIA protein]; Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; TP53 protein affects the reaction [Poly I-C results in increased phosphorylation of NFKBIA protein]
CTD PMID:18779317 PMID:20932985 PMID:23688403 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nlgn3 neuroligin 3 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of NLGN3 mRNA CTD PMID:26923065 NCBI chr  X:66,427,926...66,457,378
Ensembl chr  X:66,429,458...66,451,876
JBrowse link
G Nmu neuromedin U multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of NMU mRNA CTD PMID:26923065 NCBI chr14:31,844,564...31,872,196
Ensembl chr14:31,844,728...31,872,192
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression
ISO
EXP
pitavastatin inhibits the reaction [Poly I-C results in increased expression of NOS2 mRNA]; Pravastatin inhibits the reaction [Poly I-C results in increased expression of NOS2 mRNA]; sodium arsenite inhibits the reaction [Poly I-C results in increased expression of NOS2 mRNA]; sodium arsenite inhibits the reaction [Poly I-C results in increased expression of NOS2 protein]; Sodium Selenite inhibits the reaction [Poly I-C results in increased expression of NOS2 protein]
Diclofenac promotes the reaction [Poly I-C results in increased expression of NOS2 mRNA]
Poly I-C results in increased expression of NOS2 mRNA; Poly I-C results in increased expression of NOS2 protein
CTD PMID:17321468 PMID:18279804 PMID:18323514 PMID:21195166 PMID:23939143 More... NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nrsn1 neurensin 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of NRSN1 mRNA CTD PMID:26923065 NCBI chr17:39,806,238...39,824,550
Ensembl chr17:39,806,238...39,823,813
JBrowse link
G Nuf2 NUF2 component of NDC80 kinetochore complex multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of NUF2 mRNA CTD PMID:26923065 NCBI chr13:81,693,675...81,722,765
Ensembl chr13:81,693,598...81,722,766
JBrowse link
G Oas1a 2'-5' oligoadenylate synthetase 1A increases expression
multiple interactions
ISO Poly I-C results in increased expression of OAS1 mRNA
[[Poly I-C co-treated with Interferon-alpha] results in increased activity of OAS1 protein] which results in increased abundance of 2',5'-oligoadenylate; [Poly I-C co-treated with Interferon-alpha] results in increased activity of OAS1 protein; IRF7 protein mutant form inhibits the reaction [Poly I-C results in increased expression of OAS1 mRNA]; Nicotine inhibits the reaction [Poly I-C results in increased expression of OAS1 mRNA]
CTD PMID:17669408 PMID:22240577 PMID:26055709 PMID:31154625 NCBI chr12:35,669,798...35,680,505
Ensembl chr12:35,669,801...35,680,517
JBrowse link
G Oas2 2'-5' oligoadenylate synthetase 2 increases expression ISO Poly I-C results in increased expression of OAS2 mRNA CTD PMID:22240577 PMID:22558189 NCBI chr12:35,802,824...35,830,778
Ensembl chr12:35,806,759...35,829,371
JBrowse link
G Or4e1 olfactory receptor family 4 subfamily E member 2 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of OR4E1 mRNA CTD PMID:26923065 NCBI chr15:25,201,369...25,211,302
Ensembl chr15:25,196,602...25,211,463
JBrowse link
G P2rx7 purinergic receptor P2X 7 decreases expression
multiple interactions
ISO Poly I-C results in decreased expression of P2RX7 protein
Suramin inhibits the reaction [Poly I-C results in decreased expression of P2RX7 protein]
CTD PMID:23516405 NCBI chr12:33,889,709...33,934,168
Ensembl chr12:33,879,745...33,934,619
JBrowse link
G P2ry2 purinergic receptor P2Y2 decreases expression
multiple interactions
ISO Poly I-C results in decreased expression of P2RY2 protein
Suramin inhibits the reaction [Poly I-C results in decreased expression of P2RY2 protein]
CTD PMID:23516405 NCBI chr 1:155,352,050...155,367,423
Ensembl chr 1:155,351,165...155,367,632
JBrowse link
G Pak2 p21 (RAC1) activated kinase 2 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of PAK2 mRNA CTD PMID:26923065 NCBI chr11:68,707,940...68,768,816
Ensembl chr11:68,707,969...68,768,816
JBrowse link
G Pard6g par-6 family cell polarity regulator gamma multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of PARD6G mRNA CTD PMID:26923065 NCBI chr18:73,497,992...73,565,048
Ensembl chr18:73,498,021...73,565,029
JBrowse link
G Pcmtd1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of PCMTD1 mRNA CTD PMID:26923065 NCBI chr 5:12,284,711...12,355,680
Ensembl chr 5:12,284,711...12,354,899
JBrowse link
G Pdap1 PDGFA associated protein 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of PDAP1 mRNA CTD PMID:26923065 NCBI chr12:9,470,652...9,480,880
Ensembl chr12:9,470,574...9,535,374
JBrowse link
G Pdcd6ip programmed cell death 6 interacting protein multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of PDCD6IP mRNA CTD PMID:26923065 NCBI chr 8:113,590,998...113,646,795
Ensembl chr 8:113,590,998...113,646,773
JBrowse link
G Pdha1l1 pyruvate dehydrogenase (lipoamide) alpha 1-like 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of PDHA1L1 mRNA CTD PMID:26923065 NCBI chr16:82,511,483...82,514,378
Ensembl chr16:82,511,511...82,514,372
JBrowse link
G Pgam1-ps11 phosphoglycerate mutase 1, pseudogene 11 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of PGAM1-PS11 mRNA CTD PMID:26923065 NCBI chr10:51,449,141...51,480,570 JBrowse link
G Phactr1 phosphatase and actin regulator 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of PHACTR1 mRNA CTD PMID:26923065 NCBI chr17:21,560,364...22,040,166
Ensembl chr17:21,562,721...22,039,831
JBrowse link
G Phf7 PHD finger protein 7 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of PHF7 mRNA CTD PMID:26923065 NCBI chr16:6,433,535...6,446,314
Ensembl chr16:6,433,537...6,446,911
JBrowse link
G Pkib cAMP-dependent protein kinase inhibitor beta multiple interactions
decreases expression
EXP [Poly I-C co-treated with HU 211] results in decreased expression of PKIB mRNA
Poly I-C results in decreased expression of PKIB mRNA
CTD PMID:26923065 NCBI chr20:36,965,172...37,062,190
Ensembl chr20:36,905,340...37,062,187
JBrowse link
G Plcb1 phospholipase C beta 1 increases expression ISO Poly I-C results in increased expression of PLCB1 mRNA CTD PMID:24889602 NCBI chr 3:122,059,988...122,772,896
Ensembl chr 3:122,060,031...122,772,869
JBrowse link
G Plcxd2 phosphatidylinositol-specific phospholipase C, X domain containing 2 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of PLCXD2 mRNA CTD PMID:26923065 NCBI chr11:54,800,977...54,853,348
Ensembl chr11:54,789,477...54,853,344
JBrowse link
G Plekha8 pleckstrin homology domain containing A8 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of PLEKHA8 mRNA CTD PMID:26923065 NCBI chr 4:83,723,470...83,774,081
Ensembl chr 4:83,723,561...83,774,081
JBrowse link
G Plppr4 phospholipid phosphatase related 4 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of PLPPR4 mRNA CTD PMID:26923065 NCBI chr 2:205,371,317...205,412,302
Ensembl chr 2:205,371,322...205,412,302
JBrowse link
G Pmvk phosphomevalonate kinase multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of PMVK mRNA CTD PMID:26923065 NCBI chr 2:174,876,586...174,886,365
Ensembl chr 2:174,876,657...174,886,364
JBrowse link
G Pou5f1 POU class 5 homeobox 1 multiple interactions
increases expression
ISO Poly I-C promotes the reaction [MSI1 protein results in increased expression of POU5F1 protein]
Poly I-C results in increased expression of POU5F1 protein
CTD PMID:29486283 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891
JBrowse link
G Prf1 perforin 1 multiple interactions
increases expression
ISO Particulate Matter inhibits the reaction [Poly I-C results in increased expression of PRF1 protein]; Vehicle Emissions inhibits the reaction [Poly I-C results in increased expression of PRF1 protein]
Poly I-C results in increased expression of PRF1 mRNA; Poly I-C results in increased expression of PRF1 protein
CTD PMID:23618096 NCBI chr20:29,246,202...29,251,712
Ensembl chr20:29,246,202...29,251,701
JBrowse link
G Prkci protein kinase C, iota multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of PRKCI mRNA CTD PMID:26923065 NCBI chr 2:112,321,919...112,382,305
Ensembl chr 2:112,321,929...112,382,352
JBrowse link
G Prodh2 proline dehydrogenase 2 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of PRODH2 mRNA CTD PMID:26923065 NCBI chr 1:85,753,558...85,767,165
Ensembl chr 1:85,753,644...85,767,162
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
ISO Poly I-C results in increased expression of PTGS2 protein
[Poly I-C results in increased susceptibility to 4-iodo-2,5-dimethoxyphenylisopropylamine] which results in increased expression of PTGS2 mRNA; Poly I-C promotes the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of PTGS2 mRNA]; resveratrol inhibits the reaction [Poly I-C results in increased expression of PTGS2 protein]; Sodium Selenite inhibits the reaction [Poly I-C results in increased expression of PTGS2 protein]
CTD PMID:16116226 PMID:18279804 PMID:24889602 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Pvalb parvalbumin multiple interactions EXP [Poly I-C co-treated with Cannabidiol] results in increased expression of PVALB protein CTD PMID:31326506 NCBI chr 7:109,772,939...109,787,954
Ensembl chr 7:109,772,593...109,784,561
JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions EXP
ISO
[Poly I-C co-treated with HU 211] results in decreased expression of RAC1 mRNA
[Poly I-C co-treated with Atorvastatin] results in decreased expression of RAC1 mRNA; [Poly I-C co-treated with Ivermectin] results in decreased expression of RAC1 mRNA
CTD PMID:26923065 PMID:34696514 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251
JBrowse link
G Rarb retinoic acid receptor, beta multiple interactions ISO [Arsenicals co-treated with Poly I-C co-treated with Alitretinoin] results in decreased expression of RARB mRNA; [Arsenicals co-treated with Poly I-C co-treated with Alitretinoin] results in decreased expression of RARB protein; [Arsenicals co-treated with Poly I-C] affects the expression of RARB mRNA; [Arsenicals co-treated with Poly I-C] results in decreased expression of RARB protein CTD PMID:34303791 NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288
JBrowse link
G Rdm1 RAD52 motif containing 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of RDM1 mRNA CTD PMID:26923065 NCBI chr10:86,562,871...86,573,034
Ensembl chr10:86,539,553...86,573,034
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects localization
increases phosphorylation
multiple interactions
ISO Poly I-C affects the localization of RELA protein
Poly I-C results in increased phosphorylation of RELA protein
TP53 protein affects the reaction [Poly I-C affects the localization of RELA protein]
CTD PMID:18779317 PMID:24709138 PMID:27836898 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rgs4 regulator of G-protein signaling 4 increases expression ISO Poly I-C results in increased expression of RGS4 mRNA CTD PMID:24889602 NCBI chr13:81,936,775...81,943,103
Ensembl chr13:81,936,775...81,943,068
JBrowse link
G Rhoa ras homolog family member A multiple interactions ISO [Poly I-C co-treated with Atorvastatin co-treated with Ivermectin] results in increased expression of RHOA mRNA; [Poly I-C co-treated with Atorvastatin] results in increased expression of RHOA mRNA CTD PMID:34696514 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
JBrowse link
G Rig1 RNA sensor RIG-1 increases expression
multiple interactions
ISO Poly I-C results in increased expression of RIGI mRNA
IRF7 protein mutant form inhibits the reaction [Poly I-C results in increased expression of RIGI mRNA]; Nicotine inhibits the reaction [Poly I-C results in increased expression of RIGI mRNA]
CTD PMID:27183587 PMID:30341573 PMID:31154625 NCBI chr 5:55,321,351...55,369,947
Ensembl chr 5:55,321,235...55,370,819
JBrowse link
G Rimbp2 RIMS binding protein 2 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of RIMBP2 mRNA CTD PMID:26923065 NCBI chr12:27,747,615...27,946,256
Ensembl chr12:27,747,980...27,956,763
JBrowse link
G Rimoc1 RAB7A interacting MON1-CCZ1 complex subunit 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of RIMOC1 mRNA CTD PMID:26923065 NCBI chr 2:53,189,787...53,203,981
Ensembl chr 2:53,189,790...53,203,821
JBrowse link
G rnf141 ring finger protein 141 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of RNF141 mRNA CTD PMID:26923065 NCBI chr 1:164,933,972...164,957,081
Ensembl chr 1:164,931,077...164,957,118
JBrowse link
G Rpl31 ribosomal protein L31 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of RPL31 mRNA CTD PMID:26923065 NCBI chr 9:41,647,397...41,651,441
Ensembl chr 9:41,647,426...41,662,129
JBrowse link
G Rps6kb2 ribosomal protein S6 kinase B2 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of RPS6KB2 mRNA CTD PMID:26923065 NCBI chr 1:201,451,265...201,458,096
Ensembl chr 1:201,451,265...201,458,078
JBrowse link
G Rtn4rl1 reticulon 4 receptor-like 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of RTN4RL1 mRNA CTD PMID:26923065 NCBI chr10:60,043,246...60,116,977
Ensembl chr10:60,043,002...60,116,978
JBrowse link
G S100a3 S100 calcium binding protein A3 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of S100A3 mRNA CTD PMID:26923065 NCBI chr 2:176,034,283...176,089,702
Ensembl chr 2:176,049,520...176,089,702
JBrowse link
G Sema6d semaphorin 6D multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of SEMA6D mRNA CTD PMID:26923065 NCBI chr 3:111,883,415...111,941,100
Ensembl chr 3:111,883,872...111,941,094
JBrowse link
G Septin6 septin 6 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of SEPTIN6 mRNA CTD PMID:26923065 NCBI chr  X:116,153,255...116,230,334
Ensembl chr  X:116,153,255...116,230,115
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions
increases expression
ISO Chloroquine inhibits the reaction [Poly I-C results in increased expression of SERPINE1 mRNA]; Chloroquine inhibits the reaction [Poly I-C results in increased expression of SERPINE1 protein]; Hydroxychloroquine inhibits the reaction [Poly I-C results in increased expression of SERPINE1 mRNA]; Hydroxychloroquine inhibits the reaction [Poly I-C results in increased expression of SERPINE1 protein]; TLR3 mRNA promotes the reaction [Poly I-C results in increased expression of SERPINE1 mRNA]
Poly I-C results in increased expression of SERPINE1 mRNA; Poly I-C results in increased expression of SERPINE1 protein
CTD PMID:30341573 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Sesn2 sestrin 2 increases expression ISO Poly I-C results in increased expression of SESN2 mRNA CTD PMID:25637945 NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260
JBrowse link
G Sgtb small glutamine rich tetratricopeptide repeat co-chaperone beta multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of SGTB mRNA CTD PMID:26923065 NCBI chr 2:35,233,045...35,269,527
Ensembl chr 2:35,233,042...35,269,518
JBrowse link
G Sh3rf1 SH3 domain containing ring finger 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of SH3RF1 mRNA CTD PMID:26923065 NCBI chr16:28,735,522...28,901,261
Ensembl chr16:28,735,440...28,901,644
JBrowse link
G Shroom2 shroom family member 2 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of SHROOM2 mRNA CTD PMID:26923065 NCBI chr  X:21,812,469...21,983,724
Ensembl chr  X:21,812,469...21,984,153
JBrowse link
G Sidt1 SID1 transmembrane family, member 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of SIDT1 mRNA CTD PMID:26923065 NCBI chr11:56,362,788...56,459,939
Ensembl chr11:56,363,512...56,459,050
JBrowse link
G Slc14a1 solute carrier family 14 member 1 (Kidd blood group) multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of SLC14A1 mRNA CTD PMID:26923065 NCBI chr18:71,565,453...71,608,807
Ensembl chr18:71,565,454...71,595,146
JBrowse link
G Slc17a7 solute carrier family 17 member 7 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of SLC17A7 mRNA CTD PMID:26923065 NCBI chr 1:95,649,709...95,661,591
Ensembl chr 1:95,649,745...95,661,588
JBrowse link
G Slc25a12 solute carrier family 25 member 12 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of SLC25A12 mRNA CTD PMID:26923065 NCBI chr 3:56,097,166...56,191,841
Ensembl chr 3:56,097,269...56,192,100
JBrowse link
G Slc25a14 solute carrier family 25 member 14 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of SLC25A14 mRNA CTD PMID:26923065 NCBI chr  X:127,807,630...127,845,823
Ensembl chr  X:127,807,449...127,845,823
JBrowse link
G Slc2a13 solute carrier family 2 member 13 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of SLC2A13 mRNA CTD PMID:26923065 NCBI chr 7:122,399,329...122,726,605
Ensembl chr 7:122,399,330...122,726,605
JBrowse link
G Slc3a1 solute carrier family 3 member 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of SLC3A1 mRNA CTD PMID:26923065 NCBI chr 6:9,608,169...9,641,881
Ensembl chr 6:9,608,178...9,641,907
JBrowse link
G Slc4a10 solute carrier family 4 member 10 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of SLC4A10 mRNA CTD PMID:26923065 NCBI chr 3:46,665,076...46,959,088
Ensembl chr 3:46,665,265...46,957,268
JBrowse link
G Smarcd1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of SMARCD1 mRNA CTD PMID:26923065 NCBI chr 7:130,829,783...130,840,323
Ensembl chr 7:130,829,768...130,840,323
JBrowse link
G Snd1 staphylococcal nuclease and tudor domain containing 1 affects localization ISO Poly I-C affects the localization of SND1 protein CTD PMID:22240577 NCBI chr 4:57,095,205...57,494,501
Ensembl chr 4:57,095,208...57,530,843
JBrowse link
G Snrk SNF related kinase multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of SNRK mRNA CTD PMID:26923065 NCBI chr 8:121,779,704...121,833,949
Ensembl chr 8:121,793,302...121,832,323
JBrowse link
G Socs1 suppressor of cytokine signaling 1 increases expression
multiple interactions
ISO Poly I-C results in increased expression of SOCS1 mRNA
Progesterone promotes the reaction [Poly I-C results in increased expression of SOCS1 mRNA]
CTD PMID:22546503 NCBI chr10:4,882,651...4,884,342
Ensembl chr10:4,882,560...4,884,383
JBrowse link
G Socs3 suppressor of cytokine signaling 3 increases expression ISO Poly I-C results in increased expression of SOCS3 mRNA CTD PMID:21195166 NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787
JBrowse link
G Sod2 superoxide dismutase 2 increases expression EXP Poly I-C results in increased expression of SOD2 mRNA CTD PMID:23939143 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Sox2 SRY-box transcription factor 2 increases expression
multiple interactions
ISO Poly I-C results in increased expression of SOX2 protein
Poly I-C promotes the reaction [MSI1 protein results in increased expression of SOX2 protein]
CTD PMID:29486283 NCBI chr 2:117,536,929...117,539,340
Ensembl chr 2:117,536,929...117,539,338
JBrowse link
G Spag6 sperm associated antigen 6 decreases expression EXP Poly I-C results in decreased expression of SPAG6 mRNA CTD PMID:26923065 NCBI chr17:81,352,372...81,401,504
Ensembl chr17:81,349,084...81,401,501
JBrowse link
G Srsf12 serine and arginine rich splicing factor 12 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of SRSF12 mRNA CTD PMID:26923065 NCBI chr 5:47,606,526...47,631,509
Ensembl chr 5:47,606,285...47,629,778
JBrowse link
G Srsf7 serine and arginine rich splicing factor 7 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of SRSF7 mRNA CTD PMID:26923065 NCBI chr 6:14,811,775...14,818,968
Ensembl chr 6:14,811,808...14,818,965
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions
increases expression
increases phosphorylation
ISO sodium arsenite inhibits the reaction [Poly I-C results in increased phosphorylation of STAT1 protein]
Poly I-C results in increased expression of STAT1 mRNA
IRF7 protein mutant form inhibits the reaction [Poly I-C results in increased expression of STAT1 mRNA]; Nicotine inhibits the reaction [Poly I-C results in increased expression of STAT1 mRNA]
CTD PMID:30726814 PMID:31154625 NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
JBrowse link
G Stat2 signal transducer and activator of transcription 2 multiple interactions
increases expression
ISO IRF7 protein mutant form inhibits the reaction [Poly I-C results in increased expression of STAT2 mRNA] CTD PMID:31154625 NCBI chr 7:702,565...718,349
Ensembl chr 7:702,495...718,967
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO IL6 protein affects the reaction [Poly I-C results in increased phosphorylation of and results in increased activity of STAT3 protein]; Poly I-C results in increased phosphorylation of and results in increased activity of STAT3 protein CTD PMID:21195166 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Stxbp6 syntaxin binding protein 6 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of STXBP6 mRNA CTD PMID:26923065 NCBI chr 6:61,920,756...62,157,405
Ensembl chr 6:61,920,756...62,158,024
JBrowse link
G Svip small VCP interacting protein multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of SVIP mRNA CTD PMID:26923065 NCBI chr 1:101,587,128...101,592,818
Ensembl chr 1:101,587,128...101,593,116
JBrowse link
G Syt11 synaptotagmin 11 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of SYT11 mRNA CTD PMID:26923065 NCBI chr 2:174,206,032...174,232,540
Ensembl chr 2:174,206,191...174,231,964
JBrowse link
G Tbc1d9 TBC1 domain family member 9 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of TBC1D9 mRNA CTD PMID:26923065 NCBI chr19:24,842,166...24,951,383
Ensembl chr19:24,842,205...24,943,129
JBrowse link
G Tbk1 TANK-binding kinase 1 multiple interactions
increases phosphorylation
ISO APPL1 protein promotes the reaction [Poly I-C results in increased phosphorylation of TBK1 protein]; bafilomycin A1 promotes the reaction [Poly I-C results in increased phosphorylation of TBK1 protein] CTD PMID:25780039 NCBI chr 7:57,077,830...57,110,868
Ensembl chr 7:57,077,830...57,110,892
JBrowse link
G Tecrl2 trans-2,3-enoyl-CoA reductase like 2 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of TECRL2 mRNA CTD PMID:26923065 NCBI chr 1:47,263,647...47,264,682 JBrowse link
G Tfb1m transcription factor B1, mitochondrial multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of TFB1M mRNA CTD PMID:26923065 NCBI chr 1:44,115,240...44,161,737
Ensembl chr 1:44,119,166...44,161,709
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases secretion ISO Poly I-C results in increased secretion of TGFB1 protein CTD PMID:34740670 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Thy1 Thy-1 cell surface antigen multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of THY1 mRNA CTD PMID:26923065 NCBI chr 8:44,389,495...44,394,688
Ensembl chr 8:44,389,513...44,394,659
JBrowse link
G Tial1 Tia1 cytotoxic granule-associated RNA binding protein-like 1 affects localization ISO Poly I-C affects the localization of TIAL1 protein CTD PMID:22240577 NCBI chr 1:183,008,358...183,045,092
Ensembl chr 1:183,009,253...183,031,637
JBrowse link
G Ticam1 TIR domain containing adaptor molecule 1 increases expression ISO Poly I-C results in increased expression of TICAM1 mRNA CTD PMID:21418039 NCBI chr 9:1,102,559...1,111,023
Ensembl chr 9:1,102,366...1,123,147
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression ISO Poly I-C results in increased expression of TIMP1 mRNA CTD PMID:21195166 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Tlr2 toll-like receptor 2 increases expression ISO Poly I-C results in increased expression of TLR2 mRNA CTD PMID:17669408 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
JBrowse link
G Tlr3 toll-like receptor 3 multiple interactions
increases activity
increases expression
ISO
EXP
[[Poly I-C binds to and results in increased activity of TLR3 protein] which co-treated with Nanotubes, Carbon] results in increased secretion of IL12B protein; [[Poly I-C binds to and results in increased activity of TLR3 protein] which co-treated with Nanotubes, Carbon] results in increased secretion of TNF protein; [Poly I-C binds to TLR3 protein] which affects the susceptibility to 1-aminopyrene; [Poly I-C binds to TLR3 protein] which affects the susceptibility to 1-nitropyrene; [Poly I-C binds to TLR3 protein] which affects the susceptibility to pyrene; [Vehicle Emissions analog co-treated with Poly I-C] results in increased expression of TLR3 mRNA; [Vehicle Emissions analog co-treated with Poly I-C] results in increased expression of TLR3 protein; Chloroquine inhibits the reaction [Poly I-C results in increased activity of TLR3 protein]; Poly I-C binds to and results in increased activity of TLR3 protein; Quinacrine inhibits the reaction [Poly I-C results in increased activity of TLR3 protein]; TLR3 mRNA promotes the reaction [Poly I-C results in increased expression of IL6 mRNA]; TLR3 mRNA promotes the reaction [Poly I-C results in increased expression of SERPINE1 mRNA]; TLR3 protein affects the reaction [Poly I-C results in increased expression of CXCL8 mRNA]; TLR3 protein affects the reaction [Poly I-C results in increased expression of IFNB1 mRNA]
MIR26A mRNA inhibits the reaction [Poly I-C results in increased activity of TLR3 protein]
Poly I-C results in increased expression of TLR3 mRNA
cinnamaldehyde inhibits the reaction [Poly I-C results in increased expression of TLR3 mRNA]
CTD PMID:16399790 PMID:17669408 PMID:18306459 PMID:18779317 PMID:21398612 More... NCBI chr16:46,821,980...46,837,900
Ensembl chr16:46,822,039...46,836,545
JBrowse link
G Tlr7 toll-like receptor 7 increases expression ISO Poly I-C results in increased expression of TLR7 mRNA CTD PMID:17669408 NCBI chr  X:27,027,380...27,054,309
Ensembl chr  X:27,027,425...27,054,754
JBrowse link
G Tmem266 transmembrane protein 266 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of TMEM266 mRNA CTD PMID:26923065 NCBI chr 8:55,707,122...55,820,692
Ensembl chr 8:55,707,122...55,820,692
JBrowse link
G Tmem273 transmembrane protein 273 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of TMEM273 mRNA CTD PMID:26923065 NCBI chr16:8,049,565...8,081,981
Ensembl chr16:8,049,669...8,081,981
JBrowse link
G Tmprss2 transmembrane serine protease 2 decreases response to substance ISO TMPRSS2 gene mutant form results in decreased susceptibility to Poly I-C CTD PMID:30626688 NCBI chr11:36,934,306...36,973,779
Ensembl chr11:36,934,306...36,973,715
JBrowse link
G Tmx1 thioredoxin-related transmembrane protein 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of TMX1 mRNA CTD PMID:26923065 NCBI chr 6:88,960,691...88,971,744
Ensembl chr 6:88,960,695...88,971,301
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
increases secretion
ISO
EXP
2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane promotes the reaction [Poly I-C results in increased expression of TNF protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Poly I-C results in increased secretion of TNF protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Poly I-C results in increased secretion of TNF protein]; 4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol promotes the reaction [Poly I-C results in increased expression of TNF protein]; [[Poly I-C binds to and results in increased activity of TLR3 protein] which co-treated with Nanotubes, Carbon] results in increased secretion of TNF protein; CEP-11004 inhibits the reaction [Poly I-C results in increased secretion of TNF protein]; CpG ODN 2006 inhibits the reaction [Poly I-C results in increased secretion of TNF protein]; Estradiol promotes the reaction [Poly I-C results in increased expression of TNF protein]; N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide inhibits the reaction [Poly I-C results in increased secretion of TNF protein]; pyrazolanthrone inhibits the reaction [Poly I-C results in increased secretion of TNF protein]; RTKI cpd inhibits the reaction [Poly I-C results in increased secretion of TNF protein]; SB 203580 inhibits the reaction [Poly I-C results in increased secretion of TNF protein]
Poly I-C results in increased expression of TNF mRNA; Poly I-C results in increased expression of TNF protein
cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester inhibits the reaction [Poly I-C results in increased expression of TNF mRNA]; MIR26A mRNA inhibits the reaction [Poly I-C results in increased expression of TNF mRNA]; MIR26A mRNA inhibits the reaction [Poly I-C results in increased expression of TNF protein]
APPL1 protein inhibits the reaction [Poly I-C results in increased expression of TNF protein]; Citrinin inhibits the reaction [Poly I-C results in increased expression of TNF mRNA]; Citrinin inhibits the reaction [Poly I-C results in increased expression of TNF protein]; Cycloheximide inhibits the reaction [Poly I-C results in increased secretion of TNF protein]; Dimethyl Sulfoxide inhibits the reaction [Poly I-C results in increased secretion of TNF protein]; Ethanol inhibits the reaction [Poly I-C results in increased expression of TNF mRNA]; Ethanol inhibits the reaction [Poly I-C results in increased expression of TNF protein]; Ethanol inhibits the reaction [Poly I-C results in increased secretion of TNF protein]; Ethanol promotes the reaction [Hydroxamic Acids analog promotes the reaction [Dimethyl Sulfoxide inhibits the reaction [Poly I-C results in increased secretion of TNF protein]]]; Hydroxamic Acids analog inhibits the reaction [Poly I-C results in increased secretion of TNF protein]; Hydroxamic Acids analog promotes the reaction [Dimethyl Sulfoxide inhibits the reaction [Poly I-C results in increased secretion of TNF protein]]; Luteolin inhibits the reaction [Poly I-C results in increased expression of TNF mRNA]; Poly I-C promotes the reaction [deoxynivalenol results in increased expression of TNF mRNA]; sodium arsenite inhibits the reaction [Poly I-C results in increased expression of TNF mRNA]
CTD PMID:16687389 PMID:17238832 PMID:17321468 PMID:17669408 PMID:17698565 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfsf10 TNF superfamily member 10 increases expression ISO Poly I-C results in increased expression of TNFSF10 mRNA; Poly I-C results in increased expression of TNFSF10 protein CTD PMID:16472598 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
JBrowse link
G Tnks2 tankyrase 2 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of TNKS2 mRNA CTD PMID:26923065 NCBI chr 1:234,567,888...234,621,079
Ensembl chr 1:234,567,858...234,621,079
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO TP53 protein affects the reaction [Poly I-C affects the localization of RELA protein]; TP53 protein affects the reaction [Poly I-C results in increased expression of CXCL8 mRNA]; TP53 protein affects the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; TP53 protein affects the reaction [Poly I-C results in increased phosphorylation of IRF3 protein]; TP53 protein affects the reaction [Poly I-C results in increased phosphorylation of NFKBIA protein]; TP53 results in increased susceptibility to [Poly I-C co-treated with Fluorouracil] CTD PMID:18779317 PMID:20367642 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tpd52 tumor protein D52 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of TPD52 mRNA CTD PMID:26923065 NCBI chr 2:92,735,365...92,816,079
Ensembl chr 2:92,735,620...92,816,622
JBrowse link
G Tpk1 thiamin pyrophosphokinase 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of TERF2IP mRNA CTD PMID:26923065 NCBI chr 4:72,170,134...72,557,707
Ensembl chr 4:72,170,134...72,557,694
JBrowse link
G Traf6 TNF receptor associated factor 6 multiple interactions ISO TRAF6 mutant form inhibits the reaction [Vehicle Emissions analog promotes the reaction [Poly I-C results in increased expression of IL6 mRNA]] CTD PMID:16399790 NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507
JBrowse link
G Trim2 tripartite motif-containing 2 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of TRIM2 mRNA CTD PMID:26923065 NCBI chr 2:169,500,628...169,652,855
Ensembl chr 2:169,500,634...169,652,927
JBrowse link
G Tslp thymic stromal lymphopoietin multiple interactions
increases expression
ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; 4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol promotes the reaction [Poly I-C results in increased expression of TSLP protein]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; [Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA; [Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein; amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; Estradiol promotes the reaction [Poly I-C results in increased expression of TSLP protein]; helenalin inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; helenalin inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; IL4 protein promotes the reaction [Poly I-C results in increased expression of TSLP mRNA]; IL4 protein promotes the reaction [Poly I-C results in increased expression of TSLP protein]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]
Poly I-C results in increased expression of TSLP mRNA; Poly I-C results in increased expression of TSLP protein
CTD PMID:23688403 PMID:30017638 NCBI chr18:24,447,409...24,454,244
Ensembl chr18:24,449,844...24,453,548
JBrowse link
G Tspyl5 TSPY-like 5 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of TSPYL5 mRNA CTD PMID:26923065 NCBI chr 7:64,881,504...64,885,512
Ensembl chr 7:64,884,225...64,885,457
JBrowse link
G Ttc3 tetratricopeptide repeat domain 3 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of TTC3 mRNA CTD PMID:26923065 NCBI chr11:33,689,119...33,788,976
Ensembl chr11:33,688,952...33,788,975
JBrowse link
G Twist1 twist family bHLH transcription factor 1 decreases expression EXP Poly I-C results in decreased expression of TWIST1 mRNA CTD PMID:26923065 NCBI chr 6:50,674,910...50,676,904
Ensembl chr 6:50,674,678...50,677,653
JBrowse link
G Twsg1 twisted gastrulation BMP signaling modulator 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of TWSG1 mRNA CTD PMID:26923065 NCBI chr 9:105,533,116...105,567,460
Ensembl chr 9:105,533,136...105,567,479
JBrowse link
G Txn1 thioredoxin 1 multiple interactions
increases expression
EXP Diclofenac inhibits the reaction [Poly I-C results in increased expression of TXN1 mRNA] CTD PMID:23939143 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
JBrowse link
G Ubl4a ubiquitin-like 4A multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of UBL4A mRNA CTD PMID:26923065 NCBI chr  X:152,151,242...152,154,094
Ensembl chr  X:152,151,460...152,154,069
JBrowse link
G Ubr1 ubiquitin protein ligase E3 component n-recognin 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of UBR1 mRNA CTD PMID:26923065 NCBI chr 3:107,813,721...107,921,701
Ensembl chr 3:107,811,392...107,922,204
JBrowse link
G Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 decreases expression EXP Poly I-C results in decreased expression of UGT2B1 mRNA CTD PMID:23939143 NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986
JBrowse link
G Usp32 ubiquitin specific peptidase 32 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of USP32 mRNA CTD PMID:26923065 NCBI chr10:69,855,895...70,029,075
Ensembl chr10:69,855,885...70,029,137
JBrowse link
G Vsnl1 visinin-like 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of VSNL1 mRNA CTD PMID:26923065 NCBI chr 6:34,038,641...34,159,479
Ensembl chr 6:34,038,642...34,159,479
JBrowse link
G Wac WW domain containing adaptor with coiled-coil multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of WAC mRNA CTD PMID:26923065 NCBI chr17:55,922,686...55,984,286
Ensembl chr17:55,923,123...55,982,301
JBrowse link
G Wdr47 WD repeat domain 47 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of WDR47 mRNA CTD PMID:26923065 NCBI chr 2:196,226,757...196,287,739
Ensembl chr 2:196,205,238...196,287,739
JBrowse link
G Zbtb6 zinc finger and BTB domain containing 6 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of ZBTB6 mRNA CTD PMID:26923065 NCBI chr 3:21,189,160...21,207,561
Ensembl chr 3:21,187,483...21,207,849
JBrowse link
G Zdhhc21 zinc finger DHHC-type palmitoyltransferase 21 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of ZDHHC21 mRNA CTD PMID:26923065 NCBI chr 5:97,227,621...97,286,866
Ensembl chr 5:97,229,345...97,286,537
JBrowse link
G Zfp354c zinc finger protein 354C multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of ZFP354C mRNA CTD PMID:26923065 NCBI chr10:35,129,720...35,145,717
Ensembl chr10:35,132,959...35,145,661
JBrowse link
G Zfp663 zinc finger protein 663 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of ZFP763 mRNA CTD PMID:26923065 NCBI chr 3:154,084,553...154,102,521
Ensembl chr 3:154,085,957...154,093,160
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19922
    role 19894
      biological role 19864
        biochemical role 19596
          metabolite 19558
            prokaryotic metabolite 18602
              bacterial metabolite 18602
                Escherichia coli metabolite 18538
                  cytidine 5'-monophosphate 327
                    2'-O-methylcytidine 5'-monophosphate + 0
                    5-methylcytidine 5'-monophosphate + 0
                    CMP 3'-end residue 0
                    CMP 5'-end residue 0
                    CMP-5'-phosphonoformic acid 0
                    CMP-sugar + 1
                    N(3)-methylcytidine 5'-monophosphate + 0
                    N(4)-acetylcytidine 5'-monophosphate 0
                    N(4)-methylcytidine 5'-monophosphate + 0
                    cytidine 5'-monophosphate residue + 325
                    cytidine 5'-phosphate 2',3'-cyclic phosphate 0
                    ddhCMP 0
                    lysidine monophosphate + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19922
    subatomic particle 19892
      composite particle 19892
        hadron 19920
          baryon 19892
            nucleon 19920
              atomic nucleus 19892
                atom 19892
                  main group element atom 19866
                    p-block element atom 19866
                      chalcogen 19587
                        oxygen atom 19587
                          oxygen molecular entity 19587
                            hydroxides 19390
                              oxoacid 18821
                                pnictogen oxoacid 14983
                                  phosphorus oxoacid 14581
                                    phosphoric acids 13915
                                      phosphoric acid 13923
                                        phosphoric acid derivative 13828
                                          phosphate 13820
                                            organic phosphate 13820
                                              carbohydrate phosphate 1871
                                                phospho sugar 1714
                                                  aldose phosphate 1713
                                                    aldopentose phosphate 1705
                                                      ribose phosphate 1700
                                                        ribonucleotide 1662
                                                          ribonucleoside 5'-phosphate 652
                                                            ribonucleoside 5'-monophosphate 366
                                                              pyrimidine ribonucleoside 5'-monophosphate 330
                                                                cytidine 5'-monophosphate 327
                                                                  2'-O-methylcytidine 5'-monophosphate + 0
                                                                  5-methylcytidine 5'-monophosphate + 0
                                                                  CMP 3'-end residue 0
                                                                  CMP 5'-end residue 0
                                                                  CMP-5'-phosphonoformic acid 0
                                                                  CMP-sugar + 1
                                                                  N(3)-methylcytidine 5'-monophosphate + 0
                                                                  N(4)-acetylcytidine 5'-monophosphate 0
                                                                  N(4)-methylcytidine 5'-monophosphate + 0
                                                                  cytidine 5'-monophosphate residue + 325
                                                                  cytidine 5'-phosphate 2',3'-cyclic phosphate 0
                                                                  ddhCMP 0
                                                                  lysidine monophosphate + 0
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