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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:liproxstatin-1
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Accession:CHEBI:173097 term browser browse the term
Definition:An azaspiro compound that is 1'H-spiro[piperidine-4,2'-quinoxaline] in which the hydrogen at position 3' is replaced by a (3-chlorobenzyl)amino group. It is a potent inhibitor of ferroptosis.
Synonyms:exact_synonym: N-(3-chlorobenzyl)-1'H-spiro[piperidine-4,2'-quinoxalin]-3'-amine
 related_synonym: Formula=C19H21ClN4;   InChI=1S/C19H21ClN4/c20-15-5-3-4-14(12-15)13-22-18-19(8-10-21-11-9-19)24-17-7-2-1-6-16(17)23-18/h1-7,12,21,24H,8-11,13H2,(H,22,23);   InChIKey=YAFQFNOUYXZVPZ-UHFFFAOYSA-N;   Lip-1;   N-[(3-chlorophenyl)methyl]-1'H-spiro[piperidine-4,2'-quinoxalin]-3'-amine;   SMILES=ClC1=CC(CNC2=NC3=CC=CC=C3NC22CCNCC2)=CC=C1;   liproxstatin1
 xref: CAS:950455-15-9;   Chemspider:20387119
 xref_mesh: MESH:C000595890
 xref: PMID:28386601;   PMID:28489094;   PMID:28975372;   PMID:31597407;   PMID:31623831;   PMID:31655003;   PMID:31682397;   PMID:32540488;   PMID:32985488;   PMID:33314758;   PMID:33343803;   PMID:33378529;   PMID:33421025;   PMID:33453994;   PMID:33497529;   PMID:33681224;   PMID:33735625;   PMID:33827043;   PMID:33889074;   PMID:33974796


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liproxstatin-1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Keap1 Kelch-like ECH-associated protein 1 increases expression ISO liproxstatin-1 results in increased expression of KEAP1 protein CTD PMID:37507096 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      chemical role 19479
        antioxidant 16148
          liproxstatin-1 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    main group molecular entity 19817
                      s-block molecular entity 19653
                        hydrogen molecular entity 19634
                          hydrides 19144
                            inorganic hydride 18161
                              pnictogen hydride 18151
                                nitrogen hydride 18064
                                  azane 17872
                                    ammonia 17871
                                      organic amino compound 17871
                                        secondary amino compound 6954
                                          liproxstatin-1 1
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