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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:ferroptosis inducer
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Accession:CHEBI:173085 term browser browse the term
Definition:Any substance that induces or promotes ferroptosis (a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides) in organisms.
Synonyms:related_synonym: ferroptosis inducers
 xref: PMID:31899616;   PMID:32015325;   PMID:33167414;   PMID:34012798;   Wikipedia:Ferroptosis


show annotations for term's descendants           Sort by:
paracetamol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGS1 prostaglandin-endoperoxide synthase 1 decreases activity EXP Acetaminophen results in decreased activity of PTGS1 protein alternative form CTD PMID:12242329 NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819 		JBrowse link
G UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 increases glucuronidation EXP UGT1A6 protein results in increased glucuronidation of Acetaminophen CTD PMID:11903872 NCBI chr25:45,081,655...45,161,584
Ensembl chr25:45,032,130...45,160,941 		JBrowse link
phenacetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 affects metabolic processing EXP CYP1A2 protein affects the metabolism of Phenacetin CTD PMID:15801540 NCBI chr30:37,818,400...37,824,192
Ensembl chr30:37,799,140...37,824,135 		JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 decreases activity EXP Phenacetin results in decreased activity of PTGS1 protein alternative form CTD PMID:12242329 NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819 		JBrowse link
simvastatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NOS3 nitric oxide synthase 3 increases expression
decreases expression		 EXP Simvastatin results in increased expression of NOS3 protein
Simvastatin results in decreased expression of NOS3 mRNA		 CTD PMID:11087217 NCBI chr16:15,054,196...15,072,454
Ensembl chr16:15,011,344...15,072,277 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 498
    role 498
      biological role 498
        biochemical role 456
          ferroptosis inducer 4
            BAY11-7085 0
            CM-272 0
            DPI2 0
            FIN56 0
            FINO2 0
            JQ1 0
            L-buthionine-(S,R)-sulfoximine + 0
            L-glutamic acid + 0
            ML-210 0
            ML162 0
            RSL3 0
            RSL5 0
            S-butyl-DL-homocysteine (S,R)-sulfoximine 0
            artesunate 0
            cisplatin 0
            disulfiram 0
            erastin 0
            ferric ammonium citrate 0
            ferroptocide 0
            ferrous ammonium sulfate (anhydrous) + 0
            hemin 0
            iFSP1 0
            lanperisone 0
            lanperisone hydrochloride 0
            paracetamol + 3
            simvastatin 1
            sorafenib + 0
            sulfasalazine 0
            talaroconvolutin A 0
            thiostrepton 0
paths to the root