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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:4-Hydroxytestosterone
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Accession:CHEBI:173052 term browser browse the term
Synonyms:exact_synonym: (8R,9S,10R,13S,14S,17S)-4,17-dihydroxy-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
 related_synonym: Formula=C19H28O3;   InChI=1S/C19H28O3/c1-18-10-8-15(20)17(22)14(18)4-3-11-12-5-6-16(21)19(12,2)9-7-13(11)18/h11-13,16,21-22H,3-10H2,1-2H3/t11-,12-,13-,16-,18+,19-/m0/s1;   InChIKey=BQOIJSIMMIDHMO-FBPKJDBXSA-N;   SMILES=O[C@@H]1[C@@]2([C@]([C@]3([C@@]([C@@]4(C(CC3)=C(O)C(=O)CC4)C)(CC2)[H])[H])(CC1)[H])C
 xref: CAS:2141-17-5;   Chemspider:141138;   DrugBank:DB01485;   LIPID_MAPS_instance:LMST02020102
 xref_mesh: MESH:C032278


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4-Hydroxytestosterone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor increases expression ISO 4,17 beta-dihydroxy-4-androstene-3-one results in increased expression of AR mRNA CTD PMID:29702199 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO 4,17 beta-dihydroxy-4-androstene-3-one inhibits the reaction [Estradiol results in increased expression of CYP1A1 mRNA] CTD PMID:10619402 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO 4,17 beta-dihydroxy-4-androstene-3-one inhibits the reaction [Estradiol results in increased expression of ESR1 mRNA] CTD PMID:29702199 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Sts steroid sulfatase decreases activity ISO 4,17 beta-dihydroxy-4-androstene-3-one metabolite results in decreased activity of STS protein CTD PMID:11600235 NCBI chr  X:42,225,131...42,233,403
Ensembl chr  X:42,225,372...42,233,402 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      biological role 19842
        molecular messenger 18659
          hormone 18489
            sex hormone 18310
              androgen 5684
                4-Hydroxytestosterone 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      carbon group element atom 19751
                        carbon atom 19748
                          organic molecular entity 19748
                            organic molecule 19700
                              organic cyclic compound 19490
                                organic polycyclic compound 17286
                                  steroid 14717
                                    hydroxy steroid 14466
                                      3-hydroxy steroid 12808
                                        4-Hydroxytestosterone 4
paths to the root