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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:estrone
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Accession:CHEBI:17263 term browser browse the term
Definition:A 17-oxo steroid that is estra-1,3,5(10)-triene substituted by an hydroxy group at position 3 and an oxo group at position 17.
Synonyms:exact_synonym: 3-hydroxyestra-1,3,5(10)-trien-17-one
 related_synonym: 3-Hydroxy-1,3,5(10)-estratrien-17-one;   Formula=C18H22O2;   InChI=1S/C18H22O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-16,19H,2,4,6-9H2,1H3/t14-,15-,16+,18+/m1/s1;   InChIKey=DNXHEGUUPJUMQT-CBZIJGRNSA-N;   SMILES=[H][C@]12CC[C@]3(C)C(=O)CC[C@@]3([H])[C@]1([H])CCc1cc(O)ccc21;   follicular hormone;   folliculin;   oestrone
 alt_id: CHEBI:14220;   CHEBI:23971;   CHEBI:4870
 xref: Beilstein:1915077;   CAS:53-16-7;   DrugBank:DB00655;   Drug_Central:3188;   Gmelin:542591;   HMDB:HMDB0000145;   KEGG:C00468;   KEGG:D00067;   KNApSAcK:C00003663;   LINCS:LSM-3837;   LIPID_MAPS_instance:LMST02010004
 xref_mesh: MESH:D004970
 xref: PDBeChem:J3Z;   PMID:11786692;   PMID:13908815;   PMID:15784278;   PMID:17447557;   PMID:19610377;   PMID:23647561;   PMID:24390165;   PMID:24398390;   Patent:FR1305992;   Patent:US1967350;   Patent:US1967351;   Reaxys:1915077;   Wikipedia:Estrone


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estrone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases expression
decreases expression
increases export		 ISO Elacridar inhibits the reaction [ABCB1 protein results in increased export of Estrone]
Estrone results in increased expression of ABCB1 mRNA; Estrone results in increased expression of ABCB1 protein
Estrone results in decreased expression of ABCB1 protein		 CTD PMID:15290871 PMID:16925584 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcc8 ATP binding cassette subfamily C member 8 increases response to substance EXP ABCC8 protein results in increased susceptibility to Estrone CTD PMID:19095654 NCBI chr 1:96,598,568...96,679,563
Ensembl chr 1:96,598,647...96,679,510 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 increases expression ISO Estrone results in increased expression of ABCG2 mRNA CTD PMID:16849015 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Abhd2 abhydrolase domain containing 2, acylglycerol lipase increases expression ISO Estrone results in increased expression of ABHD2 mRNA CTD PMID:26865669 NCBI chr 1:133,217,403...133,298,564
Ensembl chr 1:133,217,375...133,299,061 		JBrowse link
G Afp alpha-fetoprotein affects binding EXP Estrone binds to AFP protein CTD PMID:23013281 PMID:25349334 NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 increases metabolic processing
increases reduction
multiple interactions		 ISO AKR1C3 protein results in increased metabolism of Estrone
AKR1C3 protein results in increased reduction of Estrone
[AKR1C3 protein results in increased metabolism of Estrone] which results in increased chemical synthesis of Estradiol; [AKR1C3 protein results in increased reduction of Estrone] which results in increased chemical synthesis of Estradiol		 CTD PMID:19010312 PMID:20036328 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions		 ISO Estrone results in increased phosphorylation of AKT1 protein
wortmannin inhibits the reaction [Estrone results in increased phosphorylation of AKT1 protein]		 CTD PMID:21767602 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alad aminolevulinate dehydratase decreases expression ISO Estrone results in decreased expression of ALAD mRNA CTD PMID:26865669 NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474 		JBrowse link
G Alpp alkaline phosphatase, placental increases chemical synthesis ISO ALPP protein results in increased chemical synthesis of Estrone CTD PMID:1495895 NCBI chr 9:87,765,846...87,768,606
Ensembl chr 9:87,765,860...87,768,606 		JBrowse link
G Ar androgen receptor multiple interactions ISO Estrone binds to and results in increased activity of AR protein; Estrone inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein] CTD PMID:12676605 PMID:33049310 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Areg amphiregulin increases expression ISO Estrone results in increased expression of AREG mRNA CTD PMID:26865669 NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535 		JBrowse link
G Arhgdia Rho GDP dissociation inhibitor alpha decreases expression ISO Estrone results in decreased expression of ARHGDIA mRNA CTD PMID:15159206 NCBI chr10:105,854,526...105,858,020
Ensembl chr10:105,854,533...105,858,023 		JBrowse link
G Car12 carbonic anhydrase 12 increases expression ISO Estrone results in increased expression of CA12 mRNA CTD PMID:26865669 NCBI chr 8:67,274,739...67,330,428
Ensembl chr 8:67,274,359...67,330,440 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 ISO Palmitic Acid promotes the reaction [Estrone results in increased activity of CASP3 protein] CTD PMID:22700542 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 increases activity
multiple interactions		 ISO Estrone results in increased activity of CASP7 protein
Palmitic Acid promotes the reaction [Estrone results in increased activity of CASP7 protein]		 CTD PMID:22700542 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Ccng2 cyclin G2 decreases expression ISO Estrone results in decreased expression of CCNG2 mRNA CTD PMID:26865669 NCBI chr14:14,804,321...14,812,819
Ensembl chr14:14,804,322...14,812,830 		JBrowse link
G Comt catechol-O-methyltransferase increases methylation ISO COMT protein results in increased methylation of Estrone metabolite CTD PMID:22285433 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 increases expression ISO Estrone results in increased expression of CXCL12 mRNA CTD PMID:26865669 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 affects abundance ISO CYP17A1 protein affects the abundance of Estrone CTD PMID:21427057 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 affects chemical synthesis
multiple interactions
increases chemical synthesis		 ISO CYP19A1 protein affects the chemical synthesis of Estrone
[Fluconazole results in decreased activity of CYP19A1 protein] which results in decreased chemical synthesis of Estrone; [Ketoconazole results in increased activity of CYP19A1 protein] which results in increased chemical synthesis of Estrone; Estrone analog binds to and results in decreased activity of CYP19A1 protein; TNF protein promotes the reaction [CYP19A1 protein affects the chemical synthesis of Estrone]
CYP19A1 protein results in increased chemical synthesis of Estrone		 CTD PMID:16030167 PMID:16039845 PMID:16054388 PMID:31330226 NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases hydroxylation
affects binding
multiple interactions		 ISO CYP1A1 protein polymorphism results in increased hydroxylation of Estrone
CYP1A1 protein binds to Estrone
Estrone promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]		 CTD PMID:12093619 PMID:15805301 PMID:27966929 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
affects binding		 ISO CYP1A2 protein promotes the reaction [Estrone binds to Deoxyguanosine]
CYP1A2 protein binds to Estrone		 CTD PMID:21907773 PMID:27966929 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases hydroxylation
affects binding
multiple interactions
affects hydroxylation		 ISO CYP1B1 protein results in increased hydroxylation of Estrone
CYP1B1 protein binds to Estrone
Estrone binds to and results in decreased activity of CYP1B1 protein
CYP1B1 protein polymorphism affects the hydroxylation of Estrone		 CTD PMID:15763594 PMID:16207128 PMID:19563207 PMID:27966929 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO Estrone results in increased expression of CYP2B10 mRNA CTD PMID:7771797 PMID:11075820 PMID:12948398 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
affects binding		 ISO CYP3A4 protein promotes the reaction [Estrone binds to Deoxyguanosine]; Estrone inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]
CYP3A4 protein binds to Estrone		 CTD PMID:19299527 PMID:21907773 PMID:27966929 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Dhrs11 dehydrogenase/reductase 11 increases reduction ISO DHRS11 protein results in increased reduction of Estrone CTD PMID:30926317 NCBI chr10:69,698,214...69,708,294
Ensembl chr10:69,698,214...69,708,295 		JBrowse link
G Dhrs3 dehydrogenase/reductase 3 increases metabolic processing ISO DHRS3 protein results in increased metabolism of Estrone CTD PMID:25451588 NCBI chr 5:156,747,939...156,782,420
Ensembl chr 5:156,747,962...156,782,417 		JBrowse link
G Dhrs7 dehydrogenase/reductase 7 increases reduction ISO DHRS7 protein results in increased reduction of Estrone CTD PMID:24246760 NCBI chr 6:91,332,259...91,347,856
Ensembl chr 6:91,251,323...91,347,892 		JBrowse link
G Dmbt1 deleted in malignant brain tumors 1 increases expression
multiple interactions		 EXP Estrone results in increased expression of DMBT1 mRNA
fulvestrant inhibits the reaction [Estrone results in increased expression of DMBT1 mRNA]		 CTD PMID:15564322 NCBI chr 1:185,617,469...185,696,476
Ensembl chr 1:185,617,294...185,696,478 		JBrowse link
G Efna1 ephrin A1 decreases expression ISO Estrone results in decreased expression of EFNA1 mRNA CTD PMID:26865669 NCBI chr 2:174,681,676...174,689,061
Ensembl chr 2:174,681,682...174,690,866 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO Estrone inhibits the reaction [LEPR gene mutant form inhibits the reaction [EGFR protein results in increased phosphorylation of EGFR protein]]; Estrone inhibits the reaction [LEPR gene mutant form results in decreased expression of EGFR mRNA] CTD PMID:1753381 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Egr3 early growth response 3 increases expression ISO Estrone results in increased expression of EGR3 mRNA CTD PMID:15159206 PMID:26865669 NCBI chr15:45,150,335...45,156,052
Ensembl chr15:45,150,567...45,154,627 		JBrowse link
G Eno2 enolase 2 decreases expression ISO Estrone results in decreased expression of ENO2 mRNA CTD PMID:15159206 NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980 		JBrowse link
G Epha4 Eph receptor A4 decreases expression ISO Estrone results in decreased expression of EPHA4 mRNA CTD PMID:26865669 NCBI chr 9:78,815,460...78,958,139
Ensembl chr 9:78,815,460...78,958,139 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
increases expression
affects binding
increases activity		 ISO
EXP		 Estrone binds to and results in increased activity of ESR1 protein; Estrone inhibits the reaction [16 alpha-iodoestradiol binds to ESR1 protein]; Estrone inhibits the reaction [ESR1 results in increased susceptibility to Cisplatin]; Estrone inhibits the reaction [Estradiol binds to ESR1 protein]; Estrone promotes the reaction [ESR1 protein alternative form binds to ESR1 protein alternative form]; Estrone promotes the reaction [ESR1 protein binds to ESR1 protein]; Estrone promotes the reaction [ESR1 protein modified form binds to NCOA1 protein modified form]; Estrone promotes the reaction [ESR1 protein modified form binds to NRIP1 protein modified form]; Fulvestrant inhibits the reaction [Estrone results in increased activity of ESR1 protein]
Estrone results in increased expression of ESR1 mRNA
Estrone binds to ESR1 protein		 CTD PMID:9048584 PMID:11162928 PMID:11331656 PMID:11518614 PMID:11750080 More... NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
affects binding
affects localization
increases activity		 EXP
ISO		 Estrone inhibits the reaction [16 alpha-iodoestradiol binds to ESR2 protein]; Estrone inhibits the reaction [Estradiol binds to ESR2 protein alternative form]; Estrone inhibits the reaction [Estradiol binds to ESR2 protein]
Estrone binds to Esr2 protein
Estrone binds to and results in increased activity of ESR2 protein
Estrone binds to ESR2 protein
Estrone affects the localization of ESR2 protein
Estrone results in increased activity of ESR2 protein		 CTD
RGD		 PMID:8650195 PMID:9048584 PMID:9492041 PMID:11518614 PMID:19913605 More... RGD:8694130 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Fhl2 four and a half LIM domains 2 increases expression ISO Estrone results in increased expression of FHL2 mRNA CTD PMID:26865669 NCBI chr 9:45,388,979...45,462,421
Ensembl chr 9:45,388,981...45,431,192 		JBrowse link
G Foxc1 forkhead box C1 increases expression ISO Estrone results in increased expression of FOXC1 mRNA CTD PMID:26865669 NCBI chr17:32,631,379...32,635,361
Ensembl chr17:32,633,142...32,634,803 		JBrowse link
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 affects metabolic processing
multiple interactions
increases chemical synthesis		 ISO HSD17B1 protein affects the metabolism of Estrone
[HSD17B1 protein co-treated with NADP] results in increased reduction of Estrone; coumarin analog inhibits the reaction [[HSD17B1 protein co-treated with NADP] results in increased reduction of Estrone]
HSD17B1 protein results in increased chemical synthesis of Estrone		 CTD PMID:16054388 PMID:21232530 NCBI chr10:86,009,728...86,011,928
Ensembl chr10:86,009,728...86,011,927 		JBrowse link
G Hsd17b12 hydroxysteroid (17-beta) dehydrogenase 12 increases metabolic processing ISO HSD17B12 protein results in increased metabolism of Estrone CTD PMID:16166196 PMID:17641292 NCBI chr 3:79,990,048...80,113,556
Ensembl chr 3:79,990,056...80,113,617 		JBrowse link
G Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 increases chemical synthesis
affects metabolic processing		 ISO HSD17B2 protein results in increased chemical synthesis of Estrone
HSD17B2 protein affects the metabolism of Estrone		 CTD PMID:16054388 NCBI chr19:45,753,576...45,825,203
Ensembl chr19:45,753,574...45,825,202 		JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 increases chemical synthesis
affects metabolic processing		 ISO HSD17B4 protein results in increased chemical synthesis of Estrone
HSD17B4 protein affects the metabolism of Estrone		 CTD PMID:16054388 NCBI chr18:43,328,903...43,417,950
Ensembl chr18:43,328,824...43,417,952 		JBrowse link
G Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 affects metabolic processing
increases chemical synthesis		 ISO HSD17B7 protein affects the metabolism of Estrone
HSD17B7 protein results in increased chemical synthesis of Estrone		 CTD PMID:16054388 NCBI chr13:82,170,079...82,190,018
Ensembl chr13:82,173,179...82,190,017 		JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression EXP Estrone results in decreased expression of ICAM1 mRNA CTD PMID:22903158 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Id3 inhibitor of DNA binding 3 decreases expression ISO Estrone results in decreased expression of ID3 mRNA CTD PMID:26865669 NCBI chr 5:148,372,784...148,374,353
Ensembl chr 5:148,372,762...148,374,349 		JBrowse link
G Igf2 insulin-like growth factor 2 increases chemical synthesis ISO IGF2 protein results in increased chemical synthesis of Estrone CTD PMID:24055520 NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO Estrone promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein] CTD PMID:8979148 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Itgam integrin subunit alpha M decreases expression
multiple interactions		 EXP Estrone results in decreased expression of ITGAM protein
Estrone inhibits the reaction [Lipopolysaccharides results in increased expression of ITGAM protein]		 CTD PMID:22903158 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G Itgax integrin subunit alpha X decreases expression
multiple interactions		 EXP Estrone results in decreased expression of ITGAX protein
Estrone inhibits the reaction [Lipopolysaccharides results in increased expression of ITGAX protein]		 CTD PMID:22903158 NCBI chr 1:182,709,653...182,740,709
Ensembl chr 1:182,719,609...182,740,698 		JBrowse link
G Jak2 Janus kinase 2 increases expression ISO Estrone results in increased expression of JAK2 mRNA CTD PMID:26865669 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Kynu kynureninase decreases expression ISO Estrone results in decreased expression of KYNU mRNA CTD PMID:26865669 NCBI chr 3:27,778,646...27,929,470
Ensembl chr 3:27,778,772...27,929,488 		JBrowse link
G Lepr leptin receptor multiple interactions ISO Estrone inhibits the reaction [LEPR gene mutant form inhibits the reaction [EGFR protein results in increased phosphorylation of EGFR protein]]; Estrone inhibits the reaction [LEPR gene mutant form results in decreased expression of EGFR mRNA] CTD PMID:1753381 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
affects phosphorylation
multiple interactions		 ISO
EXP		 Estrone results in increased phosphorylation of MAPK1 protein
Estrone affects the phosphorylation of MAPK1 protein
4,4,',4'',4'''-(carbonylbis(imino-5,1,3-benzenetriylbis(carbonylimino)))tetrakis(benzene-1,3-disulfonate) inhibits the reaction [Estrone results in increased phosphorylation of MAPK1 protein]; 4-ethylphenol analog affects the reaction [Estrone affects the phosphorylation of MAPK1 protein]; 4-nonylphenol analog affects the reaction [Estrone affects the phosphorylation of MAPK1 protein]; 4-octylphenol analog affects the reaction [Estrone affects the phosphorylation of MAPK1 protein]; 4-propylphenol affects the reaction [Estrone affects the phosphorylation of MAPK1 protein]; bisphenol A affects the reaction [Estrone affects the phosphorylation of MAPK1 protein]; NF023 inhibits the reaction [Estrone results in increased phosphorylation of MAPK1 protein]; Nystatin inhibits the reaction [Estrone results in increased phosphorylation of MAPK1 protein]; Pertussis Toxin inhibits the reaction [Estrone results in increased phosphorylation of MAPK1 protein]
4-ethylphenol inhibits the reaction [Estrone results in increased phosphorylation of MAPK1 protein]; 4-nonylphenol inhibits the reaction [Estrone results in increased phosphorylation of MAPK1 protein]; 4-octylphenol inhibits the reaction [Estrone results in increased phosphorylation of MAPK1 protein]; 4-propylphenol inhibits the reaction [Estrone results in increased phosphorylation of MAPK1 protein]; bisphenol A inhibits the reaction [Estrone results in increased phosphorylation of MAPK1 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Estrone results in increased phosphorylation of MAPK1 protein]		 CTD PMID:20870566 PMID:20950447 PMID:21767602 PMID:22230296 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
affects phosphorylation
multiple interactions		 ISO
EXP		 Estrone results in increased phosphorylation of MAPK3 protein
Estrone affects the phosphorylation of MAPK3 protein
4,4,',4'',4'''-(carbonylbis(imino-5,1,3-benzenetriylbis(carbonylimino)))tetrakis(benzene-1,3-disulfonate) inhibits the reaction [Estrone results in increased phosphorylation of MAPK3 protein]; 4-ethylphenol analog affects the reaction [Estrone affects the phosphorylation of MAPK3 protein]; 4-nonylphenol analog affects the reaction [Estrone affects the phosphorylation of MAPK3 protein]; 4-octylphenol analog affects the reaction [Estrone affects the phosphorylation of MAPK3 protein]; 4-propylphenol affects the reaction [Estrone affects the phosphorylation of MAPK3 protein]; bisphenol A affects the reaction [Estrone affects the phosphorylation of MAPK3 protein]; NF023 inhibits the reaction [Estrone results in increased phosphorylation of MAPK3 protein]; Nystatin inhibits the reaction [Estrone results in increased phosphorylation of MAPK3 protein]; Pertussis Toxin inhibits the reaction [Estrone results in increased phosphorylation of MAPK3 protein]
4-ethylphenol inhibits the reaction [Estrone results in increased phosphorylation of MAPK3 protein]; 4-nonylphenol inhibits the reaction [Estrone results in increased phosphorylation of MAPK3 protein]; 4-octylphenol inhibits the reaction [Estrone results in increased phosphorylation of MAPK3 protein]; 4-propylphenol inhibits the reaction [Estrone results in increased phosphorylation of MAPK3 protein]; bisphenol A inhibits the reaction [Estrone results in increased phosphorylation of MAPK3 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Estrone results in increased phosphorylation of MAPK3 protein]		 CTD PMID:20870566 PMID:20950447 PMID:21767602 PMID:22230296 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mical2 microtubule associated monooxygenase, calponin and LIM domain containing 2 increases expression ISO Estrone results in increased expression of MICAL2 mRNA CTD PMID:26865669 NCBI chr 1:166,345,853...166,530,575
Ensembl chr 1:166,345,859...166,471,719
Ensembl chr 1:166,345,859...166,471,719 		JBrowse link
G Myb MYB proto-oncogene, transcription factor increases expression ISO Estrone results in increased expression of MYB mRNA CTD PMID:26865669 NCBI chr 1:15,939,771...15,973,367
Ensembl chr 1:15,939,761...15,973,057 		JBrowse link
G Mybl1 MYB proto-oncogene like 1 increases expression ISO Estrone results in increased expression of MYBL1 mRNA CTD PMID:26865669 NCBI chr 5:9,582,905...9,618,179
Ensembl chr 5:9,582,934...9,618,183 		JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO Estrone promotes the reaction [NR1I3 protein binds to NCOA1 protein]
Estrone promotes the reaction [ESR1 protein modified form binds to NCOA1 protein modified form]		 CTD PMID:23015691 PMID:23383871 NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664 		JBrowse link
G Ncoa3 nuclear receptor coactivator 3 increases expression ISO Estrone results in increased expression of NCOA3 mRNA; Estrone results in increased expression of NCOA3 protein CTD PMID:21767602 NCBI chr 3:154,738,566...154,821,395
Ensembl chr 3:154,738,581...154,818,594 		JBrowse link
G Nmrk1 nicotinamide riboside kinase 1 increases expression ISO Estrone results in increased expression of NMRK1 mRNA CTD PMID:26865669 NCBI chr 1:216,049,350...216,076,792
Ensembl chr 1:216,049,437...216,076,791 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Estrone binds to and results in increased activity of NR1I2 protein CTD PMID:33049310 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases expression
increases activity
affects binding
multiple interactions
affects localization		 ISO
EXP		 Estrone results in increased expression of NR1I3 mRNA
Estrone results in increased activity of NR1I3 protein
Estrone binds to NR1I3 protein
Estrone inhibits the reaction [KN 62 results in decreased activity of NR1I3 protein]
Estrone binds to and results in increased activity of NR1I3 protein; Estrone inhibits the reaction [KN 62 results in decreased activity of NR1I3 protein]; Estrone inhibits the reaction [Progesterone results in decreased activity of NR1I3 protein]; Estrone promotes the reaction [NR1I3 protein binds to NCOA1 protein]
Estrone affects the localization of NR1I3 mRNA		 CTD PMID:11075820 PMID:12948398 PMID:16929008 PMID:23015691 PMID:28927721 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Nrip1 nuclear receptor interacting protein 1 multiple interactions ISO Estrone promotes the reaction [ESR1 protein modified form binds to NRIP1 protein modified form] CTD PMID:23383871 NCBI chr11:14,895,843...14,979,490
Ensembl chr11:14,895,553...14,981,761 		JBrowse link
G Olfm1 olfactomedin 1 increases expression ISO Estrone results in increased expression of OLFM1 mRNA CTD PMID:26865669 NCBI chr 3:11,520,522...11,558,240
Ensembl chr 3:11,520,729...11,558,239 		JBrowse link
G Pdgfa platelet derived growth factor subunit A decreases expression ISO Estrone results in decreased expression of PDGFA mRNA CTD PMID:10731640 NCBI chr12:15,645,549...15,667,056
Ensembl chr12:15,645,541...15,666,497 		JBrowse link
G Pdzk1 PDZ domain containing 1 increases expression ISO Estrone results in increased expression of PDZK1 mRNA CTD PMID:15159206 PMID:26865669 NCBI chr 2:184,376,161...184,407,514
Ensembl chr 2:184,376,161...184,407,514 		JBrowse link
G Pgr progesterone receptor decreases expression
increases expression
multiple interactions		 ISO Estrone results in decreased expression of PGR mRNA alternative form; Estrone results in decreased expression of PGR protein alternative form
Estrone results in increased expression of PGR mRNA
fulvestrant inhibits the reaction [Estrone results in decreased expression of PGR protein alternative form]		 CTD PMID:15806153 PMID:26865669 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 decreases expression ISO Estrone results in decreased expression of PIK3R3 mRNA CTD PMID:26865669 NCBI chr 5:129,700,925...129,772,591
Ensembl chr 5:129,701,229...129,772,583 		JBrowse link
G Prl prolactin increases expression
increases secretion
multiple interactions		 EXP
ISO		 Estrone results in increased expression of PRL protein
Estrone results in increased secretion of PRL protein
4-ethylphenol inhibits the reaction [Estrone results in increased secretion of PRL protein]; 4-nonylphenol inhibits the reaction [Estrone results in increased secretion of PRL protein]; 4-octylphenol affects the reaction [Estrone results in increased secretion of PRL protein]; 4-propylphenol affects the reaction [Estrone results in increased secretion of PRL protein]; bisphenol A inhibits the reaction [Estrone results in increased secretion of PRL protein]		 CTD PMID:3780563 PMID:20950447 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Prss23 serine protease 23 increases expression ISO Estrone results in increased expression of PRSS23 mRNA CTD PMID:26865669 NCBI chr 1:143,402,725...143,422,182
Ensembl chr 1:143,401,396...143,422,091 		JBrowse link
G Rapgefl1 Rap guanine nucleotide exchange factor like 1 increases expression ISO Estrone results in increased expression of RAPGEFL1 mRNA CTD PMID:26865669 NCBI chr10:83,793,711...83,810,373
Ensembl chr10:83,793,694...83,810,371 		JBrowse link
G Rbbp8 RB binding protein 8, endonuclease increases expression ISO Estrone results in increased expression of RBBP8 mRNA CTD PMID:26865669 NCBI chr18:2,922,985...2,988,851
Ensembl chr18:2,921,286...2,988,846 		JBrowse link
G Rcl1 RNA terminal phosphate cyclase-like 1 increases expression ISO Estrone results in increased expression of RCL1 mRNA CTD PMID:26865669 NCBI chr 1:226,824,561...226,869,046
Ensembl chr 1:226,824,534...226,902,315 		JBrowse link
G Ret ret proto-oncogene increases expression ISO Estrone results in increased expression of RET mRNA CTD PMID:26865669 NCBI chr 4:151,325,969...151,368,176
Ensembl chr 4:151,326,431...151,368,176 		JBrowse link
G Rhbdf1 rhomboid 5 homolog 1 decreases expression ISO Estrone results in decreased expression of RHBDF1 mRNA CTD PMID:26865669 NCBI chr10:15,406,832...15,419,765
Ensembl chr10:15,406,859...15,419,763 		JBrowse link
G Selenbp1 selenium binding protein 1 decreases expression ISO Estrone results in decreased expression of SELENBP1 mRNA CTD PMID:15159206 NCBI chr 2:182,494,004...182,504,594
Ensembl chr 2:182,493,978...182,504,594 		JBrowse link
G Selp selectin P increases expression EXP Estrone results in increased expression of SELP mRNA CTD PMID:22903158 NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845 		JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 increases expression ISO Estrone results in increased expression of SGK1 mRNA CTD PMID:26865669 NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283 		JBrowse link
G Sgk3 serum/glucocorticoid regulated kinase family, member 3 increases expression ISO Estrone results in increased expression of SGK3 mRNA CTD PMID:26865669 NCBI chr 5:9,345,761...9,472,243
Ensembl chr 5:9,346,040...9,415,476 		JBrowse link
G Shbg sex hormone binding globulin affects binding ISO Estrone binds to SHBG protein CTD PMID:25349334 NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057 		JBrowse link
G Siah2 siah E3 ubiquitin protein ligase 2 increases expression ISO Estrone results in increased expression of SIAH2 mRNA CTD PMID:26865669 NCBI chr 2:142,913,924...142,931,752
Ensembl chr 2:142,914,003...142,931,950 		JBrowse link
G Slc12a2 solute carrier family 12 member 2 decreases expression ISO Estrone results in decreased expression of SLC12A2 mRNA CTD PMID:15159206 NCBI chr18:51,348,282...51,416,448
Ensembl chr18:51,348,302...51,416,440 		JBrowse link
G Slc18a2 solute carrier family 18 member A2 multiple interactions ISO Estrone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SLC18A2 protein] CTD PMID:16011487 NCBI chr 1:258,413,748...258,449,143
Ensembl chr 1:258,413,959...258,448,325 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Estrone inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions ISO Estrone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased activity of SLC6A3 protein] CTD PMID:16011487 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO Estrone results in increased expression of SLC7A11 mRNA CTD PMID:15159206 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
G Slc7a5 solute carrier family 7 member 5 increases expression ISO Estrone results in increased expression of SLC7A5 mRNA CTD PMID:26865669 NCBI chr19:49,935,220...49,963,823
Ensembl chr19:49,935,220...49,963,823 		JBrowse link
G Smox spermine oxidase increases expression ISO Estrone results in increased expression of SMOX mRNA CTD PMID:26865669 NCBI chr 3:118,731,814...118,767,242
Ensembl chr 3:118,731,900...118,765,710 		JBrowse link
G Sts steroid sulfatase increases chemical synthesis ISO STS protein results in increased chemical synthesis of Estrone CTD PMID:16054388 NCBI chr  X:42,225,131...42,233,403
Ensembl chr  X:42,225,372...42,233,402 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases metabolic processing ISO SULT1A1 protein results in increased metabolism of Estrone CTD PMID:10623578 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562 		JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 multiple interactions
increases sulfation
decreases activity
affects sulfation		 ISO [Estrone co-treated with SULT1E1 protein] results in decreased sulfation of Ethinyl Estradiol
SULT1E1 protein results in increased sulfation of Estrone
Estrone results in decreased activity of SULT1E1 protein
Estrone affects the sulfation of SULT1E1 protein		 CTD PMID:8185618 PMID:11358677 PMID:15483196 PMID:16914110 NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275 		JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 increases metabolic processing ISO SULT2A1 protein results in increased metabolism of Estrone CTD PMID:10623578 NCBI chr 1:75,451,178...75,508,113
Ensembl chr 1:74,911,100...75,508,134 		JBrowse link
G Sult4a1 sulfotransferase family 4A, member 1 increases metabolic processing ISO SULT4A1 protein results in increased metabolism of Estrone CTD PMID:12039030 NCBI chr 7:115,216,066...115,240,156
Ensembl chr 7:115,216,066...115,240,085 		JBrowse link
G Svil supervillin increases expression ISO Estrone results in increased expression of SVIL mRNA CTD PMID:26865669 NCBI chr17:52,648,502...52,844,114
Ensembl chr17:52,648,502...52,793,404 		JBrowse link
G Tfap2c transcription factor AP-2 gamma increases expression ISO Estrone results in increased expression of TFAP2C mRNA CTD PMID:26865669 NCBI chr 3:161,315,114...161,322,998
Ensembl chr 3:161,315,031...161,322,995 		JBrowse link
G Tff1 trefoil factor 1 increases expression
multiple interactions		 ISO Estrone results in increased expression of TFF1 mRNA
fulvestrant inhibits the reaction [Estrone results in increased expression of TFF1 mRNA]		 CTD PMID:22562034 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597 		JBrowse link
G Tfpi tissue factor pathway inhibitor decreases expression ISO Estrone results in decreased expression of TFPI mRNA CTD PMID:26865669 NCBI chr 3:69,533,156...69,582,547
Ensembl chr 3:69,533,156...69,576,880 		JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO Estrone binds to and results in increased activity of THRB protein CTD PMID:33049310 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO TNF protein promotes the reaction [CYP19A1 protein affects the chemical synthesis of Estrone] CTD PMID:16030167 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of Estrone; UGT1A1 protein results in increased glucuronidation of Estrone analog CTD PMID:15117964 PMID:15472229 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of Estrone; UGT1A3 protein results in increased glucuronidation of Estrone analog CTD PMID:15117964 PMID:15472229 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of Estrone; UGT1A9 protein results in increased glucuronidation of Estrone analog CTD PMID:15472229 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 increases glucuronidation ISO UGT2B7 protein results in increased glucuronidation of Estrone; UGT2B7 protein results in increased glucuronidation of Estrone analog CTD PMID:15472229 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 decreases expression EXP Estrone results in decreased expression of VCAM1 mRNA CTD PMID:22903158 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
G Wars1 tryptophanyl-tRNA synthetase 1 increases expression ISO Estrone results in increased expression of WARS1 mRNA CTD PMID:15159206 NCBI chr 6:127,776,088...127,807,273
Ensembl chr 6:127,776,090...127,807,269 		JBrowse link
G Xiap X-linked inhibitor of apoptosis increases expression ISO Estrone results in increased expression of XIAP mRNA; Estrone results in increased expression of XIAP protein CTD PMID:21767602 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700 		JBrowse link
2-hydroxyestrone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ckb creatine kinase B multiple interactions EXP 2-hydroxyestrone inhibits the reaction [Estradiol results in increased expression of CKB] CTD PMID:10030690 NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315 		JBrowse link
G Esr1 estrogen receptor 1 affects binding
multiple interactions		 ISO 2-hydroxyestrone binds to ESR1 protein
2-hydroxyestrone binds to and results in increased activity of ESR1 protein		 CTD PMID:16728493 PMID:17713618 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO 2-hydroxyestrone binds to and results in increased activity of ESR2 protein CTD PMID:17713618 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Fshb follicle stimulating hormone subunit beta decreases expression ISO 2-hydroxyestrone results in decreased expression of FSHB protein CTD PMID:6401747 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370 		JBrowse link
G Lhb luteinizing hormone subunit beta decreases expression ISO 2-hydroxyestrone results in decreased expression of LHB protein CTD PMID:6401747 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of 2-hydroxyestrone CTD PMID:15117964 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of 2-hydroxyestrone CTD PMID:15117964 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of 2-hydroxyestrone CTD PMID:15117964 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
2-methoxyestrone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 multiple interactions ISO [HSD17B2 protein results in increased metabolism of and results in decreased activity of 2-methoxyestradiol] which results in increased chemical synthesis of 2-methoxyestrone CTD PMID:16397246 NCBI chr19:45,753,576...45,825,203
Ensembl chr19:45,753,574...45,825,202 		JBrowse link
4-hydroxyestrone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nfe2l2 NFE2 like bZIP transcription factor 2 decreases expression
decreases response to substance		 ISO 4-hydroxyestrone results in decreased expression of NFE2L2 mRNA
NFE2L2 protein results in decreased susceptibility to 4-hydroxyestrone		 CTD PMID:25231996 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of 4-hydroxyestrone CTD PMID:15117964 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of 4-hydroxyestrone CTD PMID:15117964 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of 4-hydroxyestrone CTD PMID:15117964 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 increases glucuronidation ISO UGT2B7 protein alternative form results in increased glucuronidation of 4-hydroxyestrone; UGT2B7 protein results in increased glucuronidation of 4-hydroxyestrone CTD PMID:8423545 PMID:8517101 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604 		JBrowse link
estrone 3-O-(beta-D-glucuronide) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kl Klotho increases hydrolysis
multiple interactions		 ISO KL protein results in increased hydrolysis of estrone-3-glucuronide
estrone-3-glucuronide inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides]		 CTD PMID:14701853 NCBI chr12:490,402...531,417
Ensembl chr12:490,399...530,080 		JBrowse link
estrone 3-sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca8 ATP binding cassette subfamily A member 8 affects transport ISO ABCA8 protein affects the transport of estrone sulfate CTD PMID:12379217 NCBI chr10:94,917,520...94,991,199
Ensembl chr10:94,917,520...94,990,988 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 affects export
increases activity		 ISO
EXP		 ABCC2 protein affects the export of estrone sulfate
estrone sulfate results in increased activity of ABCC2 protein; estrone sulfate results in increased activity of ABCC2 protein modified form		 CTD PMID:15652233 PMID:15904671 PMID:16046661 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 affects export
increases export
increases uptake
multiple interactions
affects transport		 ISO ABCG2 protein affects the export of estrone sulfate
ABCG2 protein results in increased export of estrone sulfate
ABCG2 protein results in increased uptake of estrone sulfate
[Adenosine Triphosphate co-treated with ABCG2 protein] results in increased uptake of estrone sulfate; Androstenedione inhibits the reaction [ABCG2 protein results in increased uptake of estrone sulfate]; Estradiol inhibits the reaction [ABCG2 protein results in increased uptake of estrone sulfate]; hippuric acid inhibits the reaction [ABCG2 protein results in increased export of estrone sulfate]; Indican inhibits the reaction [ABCG2 protein results in increased export of estrone sulfate]; Kynurenic Acid inhibits the reaction [ABCG2 protein results in increased export of estrone sulfate]; Progesterone inhibits the reaction [ABCG2 protein results in increased uptake of estrone sulfate]; Risperidone inhibits the reaction [ABCG2 protein results in increased uptake of estrone sulfate]; Sulfasalazine inhibits the reaction [[Adenosine Triphosphate co-treated with ABCG2 protein] results in increased uptake of estrone sulfate]; Testosterone inhibits the reaction [ABCG2 protein results in increased uptake of estrone sulfate]
ABCG2 protein affects the transport of estrone sulfate		 CTD PMID:15901800 PMID:18834354 PMID:19505989 PMID:21483698 PMID:22581381 More... NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Dhrs11 dehydrogenase/reductase 11 increases reduction ISO DHRS11 protein results in increased reduction of estrone sulfate CTD PMID:30926317 NCBI chr10:69,698,214...69,708,294
Ensembl chr10:69,698,214...69,708,295 		JBrowse link
G Esr2 estrogen receptor 2 affects binding EXP Estrone-3-sulfate binds to Esr2 protein RGD PMID:9048584 RGD:8694130 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Il1a interleukin 1 alpha decreases expression ISO estrone sulfate results in decreased expression of IL1A mRNA CTD PMID:10731640 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il6 interleukin 6 decreases expression ISO estrone sulfate results in decreased expression of IL6 mRNA CTD PMID:10731640 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Pdgfa platelet derived growth factor subunit A decreases expression ISO estrone sulfate results in decreased expression of PDGFA mRNA CTD PMID:10731640 NCBI chr12:15,645,549...15,667,056
Ensembl chr12:15,645,541...15,666,497 		JBrowse link
G Slc10a1 solute carrier family 10 member 1 multiple interactions ISO daidzein metabolite inhibits the reaction [SLC10A1 protein results in increased transport of estrone sulfate]; daidzein metabolite promotes the reaction [SLC10A1 protein results in increased transport of estrone sulfate]; estrone sulfate inhibits the reaction [SLC10A1 protein results in increased transport of daidzein metabolite] CTD PMID:25319728 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670 		JBrowse link
G Slc10a6 solute carrier family 10 member 6 increases transport
increases uptake
increases response to substance
multiple interactions		 ISO SLC10A6 protein results in increased transport of estrone sulfate
SLC10A6 protein results in increased uptake of estrone sulfate
SLC10A6 protein results in increased susceptibility to estrone sulfate
daidzein inhibits the reaction [SLC10A6 protein results in increased transport of estrone sulfate]; daidzein metabolite inhibits the reaction [SLC10A6 protein results in increased transport of estrone sulfate]; estrone sulfate inhibits the reaction [SLC10A6 protein results in increased transport of daidzein metabolite]; Sodium promotes the reaction [SLC10A6 protein results in increased uptake of estrone sulfate]		 CTD PMID:23562556 PMID:25319728 PMID:30186172 NCBI chr14:6,080,716...6,102,902
Ensembl chr14:6,080,717...6,103,037 		JBrowse link
G Slc17a3 solute carrier family 17 member 3 affects transport ISO SLC17A3 gene SNP affects the transport of estrone sulfate CTD PMID:21282933 NCBI chr17:41,270,804...41,300,132
Ensembl chr17:41,270,812...41,295,256 		JBrowse link
G Slc22a12 solute carrier family 22 member 12 increases uptake ISO SLC22A12 protein results in increased uptake of estrone sulfate CTD PMID:35835357 NCBI chr 1:203,845,039...203,852,496
Ensembl chr 1:203,845,048...203,853,555 		JBrowse link
G Slc22a19 solute carrier family 22, member 19 multiple interactions
affects transport		 ISO
EXP		 estrone sulfate inhibits the reaction [SLC22A19 protein results in increased uptake of ochratoxin A]
4-methylumbelliferyl sulfate inhibits the reaction [SLC22A19 protein affects the transport of estrone sulfate]; Bumetanide inhibits the reaction [SLC22A19 protein affects the transport of estrone sulfate]; Diclofenac inhibits the reaction [SLC22A19 protein affects the transport of estrone sulfate]; estradiol sulfate inhibits the reaction [SLC22A19 protein affects the transport of estrone sulfate]; Furosemide inhibits the reaction [SLC22A19 protein affects the transport of estrone sulfate]; Ibuprofen inhibits the reaction [SLC22A19 protein affects the transport of estrone sulfate]; Probenecid inhibits the reaction [SLC22A19 protein affects the transport of estrone sulfate]; Succinic Acid affects the reaction [SLC22A19 protein affects the transport of estrone sulfate]; Sulfobromophthalein inhibits the reaction [SLC22A19 protein affects the transport of estrone sulfate]		 CTD PMID:15068970 PMID:16079298 NCBI chr 1:204,910,450...204,965,538
Ensembl chr 1:204,910,455...204,965,538 		JBrowse link
G Slc22a20 solute carrier family 22 member 20 multiple interactions
increases uptake		 ISO 2,4-Dichlorophenoxyacetic Acid inhibits the reaction [SLC22A20 protein results in increased uptake of estrone sulfate]; Glutarates promotes the reaction [SLC22A20 protein results in increased uptake of estrone sulfate]; ochratoxin A inhibits the reaction [SLC22A20 protein results in increased uptake of estrone sulfate]; p-Aminohippuric Acid inhibits the reaction [SLC22A20 protein results in increased uptake of estrone sulfate]; Penicillin G inhibits the reaction [SLC22A20 protein results in increased uptake of estrone sulfate]; Probenecid inhibits the reaction [SLC22A20 protein results in increased uptake of estrone sulfate]; Salicylates inhibits the reaction [SLC22A20 protein results in increased uptake of estrone sulfate]; Uric Acid inhibits the reaction [SLC22A20 protein results in increased uptake of estrone sulfate] CTD PMID:16478971 NCBI chr 1:203,257,374...203,273,854
Ensembl chr 1:203,257,374...203,273,822 		JBrowse link
G Slc22a25 solute carrier family 22, member 25 affects transport
increases import
multiple interactions
increases uptake		 EXP
ISO		 SLC22A9 protein affects the transport of estrone sulfate
SLC22A9 protein results in increased import of estrone sulfate
candesartan cilexetil inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate]; candesartan inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate]; Dehydroepiandrosterone Sulfate inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate]; losartan carboxylic acid inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate]; Losartan inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate]; pranlukast inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate]; Probenecid inhibits the reaction [SLC22A9 protein results in increased import of estrone sulfate]; Probenecid inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate]; Tobacco Smoke Pollution inhibits the reaction [SLC22A9 protein results in increased import of estrone sulfate]; Valsartan inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate]
4-methylumbelliferyl sulfate inhibits the reaction [SLC22A9 protein affects the transport of estrone sulfate]; Glutarates affects the reaction [SLC22A9 protein affects the transport of estrone sulfate]; naphthyl sulfate inhibits the reaction [SLC22A9 protein affects the transport of estrone sulfate]; Succinic Acid inhibits the reaction [SLC22A9 protein affects the transport of estrone sulfate]		 CTD PMID:16079298 PMID:17132213 PMID:18441515 PMID:28629854 NCBI chr 1:205,338,698...205,498,486
Ensembl chr 1:205,338,699...205,433,085 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 increases uptake ISO SLC22A6 protein results in increased uptake of estrone sulfate CTD PMID:16098483 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173 		JBrowse link
G Slc22a7 solute carrier family 22 member 7 multiple interactions
increases uptake		 ISO Fumarates promotes the reaction [SLC22A7 protein results in increased uptake of estrone sulfate]; Succinates promotes the reaction [SLC22A7 protein results in increased uptake of estrone sulfate] CTD PMID:15901346 NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 multiple interactions
increases import
affects transport
increases uptake		 ISO
EXP		 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; aristolochic acid I inhibits the reaction [SLC22A8 results in increased uptake of estrone sulfate]; bisphenol A inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; bisphenol F inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; bisphenol S inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Bumetanide inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]; Cefaclor inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Cefdinir inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; cefoselis inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Cefotiam inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Ceftibuten inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Ceftizoxime inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Cephaloridine inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Cholates inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]; Cimetidine inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]; cyazofamid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Dehydroepiandrosterone inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]; Diclofenac inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]; estrone sulfate inhibits the reaction [SLC22A8 protein results in increased uptake of Famotidine]; estrone sulfate promotes the reaction [SLC22A8 results in increased export of p-Aminohippuric Acid]; Famotidine inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]; Furosemide inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]; Ibuprofen inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]; Indomethacin inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]; Probenecid inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]; Probenecid inhibits the reaction [SLC22A8 protein results in increased import of estrone sulfate]; Probenecid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Quercetin inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; rhein inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; rhein metabolite inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; tetrabromobisphenol A inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Tobacco Smoke Pollution inhibits the reaction [SLC22A8 protein results in increased import of estrone sulfate]
SLC22A8 protein results in increased uptake of estrone sulfate; SLC22A8 results in increased uptake of estrone sulfate
3,4-dihydroxymandelic acid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; 3,4-Dihydroxyphenylacetic Acid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; 5-methoxyindoleacetic acid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Bumetanide inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; estrone sulfate inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]; Furosemide inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; hexadecafluoro-nonanoic acid inhibits the reaction [SLC22A8 protein results in increased import of estrone sulfate]; Homovanillic Acid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Indocyanine Green inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; methoxytryptophol inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Penicillin G inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; perfluoro-n-heptanoic acid inhibits the reaction [SLC22A8 protein results in increased import of estrone sulfate]; perfluorodecanoic acid inhibits the reaction [SLC22A8 protein results in increased import of estrone sulfate]; perfluorooctanoic acid inhibits the reaction [SLC22A8 protein results in increased import of estrone sulfate]; Piroxicam inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Probenecid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Sulfobromophthalein inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Vanilmandelic Acid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]		 CTD PMID:10224140 PMID:11306713 PMID:15100168 PMID:15319347 PMID:15496291 More... NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 affects uptake
multiple interactions
increases uptake
increases transport
increases import		 ISO SLCO1A4 protein affects the uptake of estrone sulfate
7-hydroxymethotrexate inhibits the reaction [SLCO1A2 mRNA results in increased import of estrone sulfate]; artemisinin inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; Chloroquine inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; Mefloquine inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; Methotrexate inhibits the reaction [SLCO1A2 mRNA results in increased import of estrone sulfate]; naringin inhibits the reaction [SLCO1A2 protein alternative form results in increased uptake of estrone sulfate]; naringin inhibits the reaction [SLCO1A2 protein results in increased transport of estrone sulfate]; perfluorodecanoic acid inhibits the reaction [SLCO1A2 protein results in increased import of estrone sulfate]; Pyrimethamine inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; Quinine inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]
SLCO1A2 protein alternative form results in increased uptake of estrone sulfate; SLCO1A2 protein results in increased uptake of estrone sulfate
SLCO1A2 mRNA results in increased import of estrone sulfate; SLCO1A2 protein results in increased import of estrone sulfate		 CTD PMID:16702441 PMID:20639259 PMID:21561886 PMID:25466967 PMID:27504015 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions
increases uptake		 ISO cyazofamid inhibits the reaction [SLCO1B3 protein results in increased uptake of estrone sulfate] CTD PMID:32003934 PMID:34619012 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981 		JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 increases import
multiple interactions
increases uptake		 ISO SLCO2B1 protein results in increased import of estrone sulfate; SLCO2B1 results in increased import of estrone sulfate
2,2',4,4',5,6'-hexabromodiphenyl ether inhibits the reaction [SLCO2B1 results in increased import of estrone sulfate]; 2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [SLCO2B1 results in increased import of estrone sulfate]; [icariin results in decreased activity of SLCO2B1 protein] which results in decreased uptake of estrone sulfate; daidzein inhibits the reaction [SLCO2B1 protein results in increased transport of estrone sulfate]; daidzein metabolite inhibits the reaction [SLCO2B1 protein results in increased transport of estrone sulfate]; estrone sulfate inhibits the reaction [SLCO2B1 protein results in increased transport of daidzein metabolite]; estrone sulfate inhibits the reaction [SLCO2B1 protein results in increased uptake of Quercetin]; Mefloquine affects the reaction [SLCO2B1 protein results in increased uptake of estrone sulfate]; pentabromodiphenyl ether inhibits the reaction [SLCO2B1 results in increased import of estrone sulfate]; Rutin promotes the reaction [SLCO2B1 protein results in increased uptake of estrone sulfate]; Sulfobromophthalein inhibits the reaction [SLCO2B1 protein results in increased import of estrone sulfate]; Tobacco Smoke Pollution inhibits the reaction [SLCO2B1 protein results in increased import of estrone sulfate]		 CTD PMID:16714376 PMID:20176623 PMID:24265111 PMID:24285294 PMID:24947867 More... NCBI chr 1:153,959,288...154,007,294
Ensembl chr 1:153,959,293...154,007,353 		JBrowse link
G Slco3a1 solute carrier organic anion transporter family, member 3a1 multiple interactions ISO estrone sulfate promotes the reaction [SLCO3A1 protein results in increased uptake of simvastatin acid] CTD PMID:28887287 NCBI chr 1:128,106,232...128,388,043
Ensembl chr 1:128,106,228...128,387,925 		JBrowse link
G Sts steroid sulfatase affects metabolic processing
decreases sulfation		 ISO STS protein affects the metabolism of estrone sulfate
STS protein results in decreased sulfation of estrone sulfate		 CTD PMID:15597397 PMID:16054388 NCBI chr  X:42,225,131...42,233,403
Ensembl chr  X:42,225,372...42,233,402 		JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 multiple interactions ISO [[Oxygen deficiency co-treated with Oxygen] results in increased expression of SULT1E1 protein] which results in increased abundance of estrone sulfate CTD PMID:25922074 NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19917
    role 19887
      application 19730
        pharmaceutical 19564
          drug 19564
            antineoplastic agent 17834
              estrone 128
                15alpha-hydroxyestrone 0
                16alpha-hydroxyestrone + 0
                16beta-hydroxyestrone 0
                2-hydroxyestrone + 8
                2-methoxyestrone + 1
                2-methoxyestrone 3-sulfate 0
                4-hydroxyestrone + 5
                4-methoxyestrone + 0
                6alpha-hydroxyestrone 0
                6beta-hydroxyestrone 0
                estrone 3-O-(beta-D-glucuronide) 1
                estrone 3-sulfate 24
                estrone sodium sulfate 0
                estropipate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19917
    subatomic particle 19915
      composite particle 19915
        hadron 19915
          baryon 19915
            nucleon 19915
              atomic nucleus 19915
                atom 19915
                  main group element atom 19855
                    p-block element atom 19855
                      carbon group element atom 19774
                        carbon atom 19790
                          organic molecular entity 19790
                            organic molecule 19743
                              organic cyclic compound 19533
                                organic polycyclic compound 17311
                                  steroid 14726
                                    hydroxy steroid 14473
                                      3-hydroxy steroid 12810
                                        phenolic steroid 11309
                                          estrone 128
                                            15alpha-hydroxyestrone 0
                                            16alpha-hydroxyestrone + 0
                                            16beta-hydroxyestrone 0
                                            2-hydroxyestrone + 8
                                            2-methoxyestrone + 1
                                            2-methoxyestrone 3-sulfate 0
                                            4-hydroxyestrone + 5
                                            4-methoxyestrone + 0
                                            6alpha-hydroxyestrone 0
                                            6beta-hydroxyestrone 0
                                            estrone 3-O-(beta-D-glucuronide) 1
                                            estrone 3-sulfate 24
                                            estrone sodium sulfate 0
                                            estropipate 0
paths to the root