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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:4-methylcatechol
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Accession:CHEBI:17254 term browser browse the term
Definition:A methylcatechol having a single methyl substituent at the 4-position. It has been isolated from Picea abies.
Synonyms:related_synonym: 1,2-dihydroxy-4-methylbenzene;   2-Hydroxy-4-methylphenol;   3,4-dihydroxytoluene;   4-Methyl-1,2-dihydroxybenzene;   4-Methylpyrocatechol;   4-methyl-1,2-benzenediol;   4-methylbenzene-1,2-diol;   Formula=C7H8O2;   Homocatechol;   Homopyrocatechol;   InChI=1S/C7H8O2/c1-5-2-3-6(8)7(9)4-5/h2-4,8-9H,1H3;   InChIKey=ZBCATMYQYDCTIZ-UHFFFAOYSA-N;   SMILES=Cc1ccc(O)c(O)c1;   Toluene-3,4-diol;   p-Methylcatechol;   p-Methylpyrocatechol
 alt_id: CHEBI:12025;   CHEBI:1897;   CHEBI:20442;   CHEBI:43962
 xref: CAS:452-86-8;   DrugBank:DB04120;   HMDB:HMDB0000873;   KEGG:C06730;   KNApSAcK:C00002660
 xref_mesh: MESH:C018599
 xref: PDBeChem:MCT;   PMID:18499097;   Reaxys:636512;   UM-BBD_compID:c0126;   Wikipedia:4-Methylcatechol


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4-methylcatechol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Btc betacellulin decreases expression
multiple interactions		 EXP 4-methylcatechol results in decreased expression of BTC mRNA
4-methylcatechol results in decreased expression of and results in decreased secretion of BTC protein		 CTD PMID:29473434 NCBI chr14:16,708,447...16,746,961
Ensembl chr14:16,707,982...16,747,049 		JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions ISO 4-methylcatechol inhibits the reaction [resiniferatoxin results in decreased expression of CALCA protein] CTD PMID:18219259 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105 		JBrowse link
G Comt catechol-O-methyltransferase increases methylation ISO
EXP		 COMT protein results in increased methylation of 4-methylcatechol CTD PMID:11160877 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Inhba inhibin subunit beta A decreases expression EXP 4-methylcatechol results in decreased expression of INHBA mRNA CTD PMID:29473434 NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982 		JBrowse link
G Ins1 insulin 1 decreases expression
multiple interactions		 EXP 4-methylcatechol results in decreased expression of INS1 mRNA
[4-methylcatechol co-treated with Glucose] results in increased secretion of INS1 protein		 CTD PMID:29473434 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases expression ISO 4-methylcatechol results in increased expression of NFE2L2 mRNA CTD PMID:26862668 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Ngf nerve growth factor multiple interactions EXP 4-methylcatechol inhibits the reaction [Streptozocin results in decreased expression of NGF protein] CTD PMID:8195800 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO 4-methylcatechol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; 4-methylcatechol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:18499097 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO 4-methylcatechol inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein] CTD PMID:18499097 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Slc2a2 solute carrier family 2 member 2 decreases expression EXP 4-methylcatechol results in decreased expression of SLC2A2 mRNA CTD PMID:29473434 NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO 4-methylcatechol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; 4-methylcatechol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:18499097 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Uchl1 ubiquitin C-terminal hydrolase L1 multiple interactions ISO 4-methylcatechol inhibits the reaction [resiniferatoxin results in decreased expression of UCHL1 protein] CTD PMID:18219259 NCBI chr14:41,485,031...41,495,590
Ensembl chr14:41,485,031...41,495,590 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    role 19854
      chemical role 19507
        antioxidant 16171
          4-methylcatechol 12
            3-chloro-4-methylcatechol 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    p-block element atom 19849
                      carbon group element atom 19766
                        carbon atom 19785
                          organic molecular entity 19785
                            organic molecule 19737
                              organic cyclic compound 19526
                                organic aromatic compound 19390
                                  phenols 18674
                                    benzenediols 9157
                                      catechols 3409
                                        methylcatechol 13
                                          4-methylcatechol 12
                                            3-chloro-4-methylcatechol 0
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