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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:homocysteine
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Accession:CHEBI:17230 term browser browse the term
Definition:A sulfur-containing amino acid consisting of a glycine core with a 2-mercaptoethyl side-chain.
Synonyms:related_synonym: 2-Amino-4-mercaptobutyric acid;   2-amino-4-sulfanylbutanoic acid;   Formula=C4H9NO2S;   Hcy;   InChI=1S/C4H9NO2S/c5-3(1-2-8)4(6)7/h3,8H,1-2,5H2,(H,6,7);   InChIKey=FFFHZYDWPBMWHY-UHFFFAOYSA-N;   SMILES=NC(CCS)C(O)=O
 alt_id: CHEBI:14408;   CHEBI:5751
 xref: HMDB:HMDB0000742;   KEGG:C05330
 xref_mesh: MESH:D006710
 xref: PMID:11133260;   PMID:16596805;   PMID:18370634;   Wikipedia:Homocysteine
 cyclic_relationship: is_conjugate_acid_of CHEBI:66952;   is_tautomer_of CHEBI:58065


show annotations for term's descendants           Sort by:
homocysteine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acadm acyl-CoA dehydrogenase medium chain increases expression ISO Homocysteine results in increased expression of ACADM mRNA; Homocysteine results in increased expression of ACADM protein CTD PMID:26993217 NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147 		JBrowse link
G Ache acetylcholinesterase increases activity
decreases activity		 ISO
EXP		 Homocysteine results in increased activity of ACHE protein
Homocysteine results in decreased activity of ACHE protein		 CTD PMID:16375580 PMID:38729282 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions
increases expression		 ISO [Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of ACTA2 mRNA; [Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of ACTA2 protein; CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of ACTA2 mRNA]; CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of ACTA2 protein]
Homocysteine results in increased expression of ACTA2 mRNA; Homocysteine results in increased expression of ACTA2 protein		 CTD PMID:21647593 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Ahcy adenosylhomocysteinase multiple interactions ISO [Arsenic results in increased expression of and results in increased activity of AHCY protein] which results in increased chemical synthesis of Homocysteine CTD PMID:18487201 NCBI chr 3:143,569,134...143,584,359
Ensembl chr 3:143,569,094...143,584,393 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation		 ISO Atorvastatin inhibits the reaction [Homocysteine results in decreased phosphorylation of AKT1 protein] CTD PMID:20305681 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alb albumin multiple interactions EXP Folic Acid inhibits the reaction [Homocysteine inhibits the reaction [ALB protein binds to Bilirubin]]; Homocysteine inhibits the reaction [ALB protein binds to Bilirubin] CTD PMID:33788065 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Apoa1 apolipoprotein A1 decreases expression
multiple interactions		 ISO Homocysteine results in decreased expression of APOA1 mRNA; Homocysteine results in decreased expression of APOA1 protein
Homocysteine inhibits the reaction [Simvastatin results in increased expression of APOA1 mRNA]; Homocysteine inhibits the reaction [Simvastatin results in increased expression of APOA1 protein]		 CTD PMID:18540024 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035 		JBrowse link
G App amyloid beta precursor protein increases abundance ISO APP protein results in increased abundance of Homocysteine CTD PMID:16837103 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Atf1 activating transcription factor 1 multiple interactions EXP Homocysteine promotes the reaction [ATF1 protein binds to CCNA2 promoter] CTD PMID:8550827 NCBI chr 7:131,361,962...131,404,677
Ensembl chr 7:131,362,450...131,404,670 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
affects expression
affects localization		 ISO
EXP		 BAX protein inhibits the reaction [Cystathionine inhibits the reaction [Homocysteine results in increased activity of CASP3 protein]]; BTSA1 compound inhibits the reaction [Cystathionine inhibits the reaction [Homocysteine affects the localization of BAX protein]]; Cystathionine inhibits the reaction [Homocysteine affects the localization of BAX protein]; Cystathionine inhibits the reaction [Homocysteine results in increased expression of and affects the localization of BAX protein]; Folic Acid affects the reaction [Homocysteine affects the expression of BAX mRNA]; Folic Acid affects the reaction [Homocysteine affects the expression of BAX protein]; Homocysteine results in increased expression of and affects the localization of BAX protein; Zeranol inhibits the reaction [Homocysteine results in increased expression of BAX protein]
Homocysteine affects the expression of BAX mRNA; Homocysteine affects the expression of BAX protein
Folic Acid inhibits the reaction [Homocysteine results in increased expression of BAX mRNA]		 CTD PMID:16757814 PMID:29250709 PMID:31721048 PMID:31885769 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bche butyrylcholinesterase multiple interactions
decreases activity		 EXP Folic Acid inhibits the reaction [Homocysteine results in decreased activity of BCHE protein] CTD PMID:16442260 PMID:38729282 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
affects expression		 ISO
EXP		 Folic Acid affects the reaction [Homocysteine affects the expression of BCL2 mRNA]; Folic Acid affects the reaction [Homocysteine affects the expression of BCL2 protein]; Zeranol inhibits the reaction [Homocysteine results in decreased expression of BCL2 protein]
[Homocysteine co-treated with Sodium Glutamate] affects the expression of BCL2 mRNA; [Homocysteine co-treated with Sodium Glutamate] affects the expression of BCL2 protein; Folic Acid affects the reaction [[Homocysteine co-treated with Sodium Glutamate] affects the expression of BCL2 mRNA]; Folic Acid affects the reaction [[Homocysteine co-treated with Sodium Glutamate] affects the expression of BCL2 protein]
Homocysteine affects the expression of BCL2 mRNA; Homocysteine affects the expression of BCL2 protein		 CTD PMID:16757814 PMID:22169520 PMID:29250709 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 decreases expression
multiple interactions		 ISO Homocysteine results in decreased expression of BIRC2 mRNA; Homocysteine results in decreased expression of BIRC2 protein
Simvastatin inhibits the reaction [Homocysteine results in decreased expression of BIRC2 mRNA]; Simvastatin inhibits the reaction [Homocysteine results in decreased expression of BIRC2 protein]		 CTD PMID:19343037 NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 decreases expression
multiple interactions		 ISO Homocysteine results in decreased expression of BIRC3 mRNA; Homocysteine results in decreased expression of BIRC3 protein
Simvastatin inhibits the reaction [Homocysteine results in decreased expression of BIRC3 mRNA]; Simvastatin inhibits the reaction [Homocysteine results in decreased expression of BIRC3 protein]		 CTD PMID:19343037 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802 		JBrowse link
G Cacna2d1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 affects binding EXP Homocysteine analog binds to CACNA2D1 protein CTD PMID:16380257 NCBI chr 4:18,950,611...19,374,969
Ensembl chr 4:18,951,002...19,374,969 		JBrowse link
G Calr calreticulin increases expression ISO Homocysteine results in increased expression of CALR mRNA CTD PMID:26993217 NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414 		JBrowse link
G Casp1 caspase 1 multiple interactions
increases expression
increases activity		 ISO [Folic Acid deficiency results in increased abundance of Homocysteine] promotes the reaction [NLRC3 protein binds to PYCARD protein binds to CASP1 protein]; CASP1 protein affects the reaction [Homocysteine promotes the reaction [NLRC3 protein binds to PYCARD protein binds to CASP1 protein]]; CASP1 protein affects the reaction [Homocysteine results in decreased secretion of VEGFA protein]; Homocysteine promotes the reaction [NLRC3 protein binds to PYCARD protein binds to CASP1 protein]; PYCARD protein affects the reaction [Homocysteine promotes the reaction [NLRC3 protein binds to PYCARD protein binds to CASP1 protein]]; PYCARD protein affects the reaction [Homocysteine results in increased activity of CASP1 protein]
Homocysteine results in increased expression of CASP1 mRNA		 CTD PMID:22647887 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
increases activity
affects cleavage
affects expression		 ISO
EXP		 BAX protein inhibits the reaction [Cystathionine inhibits the reaction [Homocysteine results in increased activity of CASP3 protein]]; BTSA1 compound inhibits the reaction [Cystathionine inhibits the reaction [Homocysteine results in increased cleavage of CASP3 protein]]; Cystathionine inhibits the reaction [Homocysteine results in increased activity of and results in increased cleavage of CASP3 protein]; Folic Acid affects the reaction [Homocysteine affects the cleavage of CASP3 protein]; Folic Acid affects the reaction [Homocysteine affects the expression of CASP3 mRNA]; Homocysteine results in increased activity of and results in increased cleavage of CASP3 protein; mecobalamin inhibits the reaction [Homocysteine results in increased activity of CASP3 protein]; Simvastatin inhibits the reaction [Homocysteine results in increased activity of CASP3 protein]
Homocysteine results in increased expression of CASP3 mRNA; Homocysteine results in increased expression of CASP3 protein
Atorvastatin inhibits the reaction [Homocysteine results in increased activity of CASP3 protein]
Folic Acid inhibits the reaction [Homocysteine results in increased expression of CASP3 protein]		 CTD PMID:16715183 PMID:19343037 PMID:20305681 PMID:21237187 PMID:29250709 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 increases activity
multiple interactions		 ISO Homocysteine results in increased activity of CASP7 protein
mecobalamin inhibits the reaction [Homocysteine results in increased activity of CASP7 protein]		 CTD PMID:21237187 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp8 caspase 8 multiple interactions
affects expression		 ISO Folic Acid affects the reaction [Homocysteine affects the expression of CASP8 mRNA]; Folic Acid affects the reaction [Homocysteine affects the expression of CASP8 protein]
Homocysteine affects the expression of CASP8 mRNA; Homocysteine affects the expression of CASP8 protein		 CTD PMID:29250709 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity		 ISO BTSA1 compound inhibits the reaction [Cystathionine inhibits the reaction [Homocysteine results in increased activity of CASP9 protein]]; Cystathionine inhibits the reaction [Homocysteine results in increased activity of CASP9 protein] CTD PMID:31885769 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase decreases transport
decreases expression
multiple interactions
decreases activity		 ISO
EXP		 CAT protein results in decreased transport of Homocysteine
Homocysteine results in decreased expression of CAT protein
[CAT gene SNP results in increased susceptibility to [Air Pollutants results in increased abundance of Particulate Matter]] which results in increased abundance of Homocysteine
Homocysteine results in decreased activity of CAT protein		 CTD PMID:12631446 PMID:22964297 PMID:30477822 PMID:38729282 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cbs cystathionine beta synthase affects abundance
multiple interactions		 ISO
EXP		 CBS protein affects the abundance of Homocysteine; CBS protein affects the abundance of Homocysteine metabolite
Homocysteine inhibits the reaction [Folic Acid results in increased activity of CBS protein]		 CTD PMID:19204075 PMID:23024785 PMID:31721048 NCBI chr20:9,708,089...9,732,623
Ensembl chr20:9,708,090...9,732,764 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases expression		 ISO [Homocysteine results in increased expression of CCL2 protein] which results in increased phosphorylation of NFKBIA protein; [Homocysteine results in increased expression of CCL2 protein] which results in increased reduction of NFKBIA mRNA; acetovanillone inhibits the reaction [Homocysteine results in increased expression of CCL2 mRNA]; Folic Acid inhibits the reaction [Homocysteine results in increased expression of CCL2 mRNA]
Homocysteine results in increased expression of CCL2 mRNA; Homocysteine results in increased expression of CCL2 protein		 CTD PMID:11356643 PMID:16845898 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions
increases expression		 ISO
EXP		 [Homocysteine co-treated with Lipopolysaccharides] results in increased secretion of CCL5 protein
Homocysteine results in increased expression of CCL5 protein
Ibuprofen inhibits the reaction [Homocysteine results in increased expression of CCL5 protein]
Homocysteine results in increased expression of CCL5 mRNA		 CTD PMID:16225753 PMID:39357784 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Ccn4 cellular communication network factor 4 decreases expression ISO Homocysteine results in decreased expression of CCN4 mRNA CTD PMID:17320366 NCBI chr 7:98,645,238...98,677,253
Ensembl chr 7:98,645,182...98,677,248 		JBrowse link
G Ccna1 cyclin A1 multiple interactions
decreases methylation
decreases expression		 ISO DNMT1 protein affects the reaction [Homocysteine results in decreased expression of CCNA1 mRNA]; Homocysteine inhibits the reaction [MECP2 protein binds to CCNA1 promoter]; Homocysteine promotes the reaction [H3-4 protein modified form binds to CCNA1 promoter]; Homocysteine promotes the reaction [H4C16 protein modified form binds to CCNA1 promoter]
Homocysteine results in decreased methylation of CCNA1 promoter		 CTD PMID:17698632 NCBI chr 2:139,231,738...139,278,066
Ensembl chr 2:139,201,074...139,243,157 		JBrowse link
G Ccna2 cyclin A2 multiple interactions
increases expression		 EXP Dactinomycin inhibits the reaction [Homocysteine results in increased expression of CCNA2 mRNA]; Homocysteine promotes the reaction [ATF1 protein binds to CCNA2 promoter]
Homocysteine results in increased expression of CCNA2 mRNA; Homocysteine results in increased expression of CCNA2 protein		 CTD PMID:8550827 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Cdh3 cadherin 3 multiple interactions
decreases expression		 ISO [Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of CDH3 mRNA; [Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of CDH3 protein; acetovanillone inhibits the reaction [Homocysteine results in decreased expression of CDH3 protein]; CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of CDH3 mRNA]; CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of CDH3 protein]; CYBB mutant form inhibits the reaction [Homocysteine results in decreased expression of CDH3 protein]
Homocysteine results in decreased expression of CDH3 mRNA; Homocysteine results in decreased expression of CDH3 protein		 CTD PMID:21647593 NCBI chr19:34,393,596...34,444,084
Ensembl chr19:34,393,727...34,444,084 		JBrowse link
G Comt catechol-O-methyltransferase multiple interactions ISO [tolcapone results in decreased activity of COMT protein] inhibits the reaction [Levodopa results in increased abundance of Homocysteine] CTD PMID:16758261 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Cox5b cytochrome c oxidase subunit 5B multiple interactions ISO [Methionine deficiency co-treated with Homocysteine] affects the expression of COX5B protein CTD PMID:17116298 NCBI chr 9:38,921,980...38,923,806
Ensembl chr 9:38,921,967...38,925,052 		JBrowse link
G Crk CRK proto-oncogene, adaptor protein multiple interactions ISO [Methionine deficiency co-treated with Homocysteine] affects the expression of CRK protein CTD PMID:17116298 NCBI chr10:60,530,469...60,556,703
Ensembl chr10:60,530,464...60,553,406 		JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions
increases expression
affects localization		 ISO CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of CDH3 mRNA]; CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of CDH3 protein]; CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of TJP1 mRNA]; CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of ACTA2 mRNA]; CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of ACTA2 protein]; CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of S100A4 mRNA]; CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of S100A4 protein]; CYBB mutant form inhibits the reaction [Homocysteine results in decreased expression of CDH3 protein]; CYBB mutant form inhibits the reaction [Homocysteine results in decreased expression of TJP1 protein]; CYBB mutant form inhibits the reaction [Homocysteine results in increased abundance of Superoxides]; CYBB mutant form inhibits the reaction [Homocysteine results in increased expression of S100A4 protein]; CYBB protein affects the reaction [Homocysteine results in decreased secretion of VEGFA protein]; CYBB protein affects the reaction [Homocysteine results in increased abundance of Superoxides]; CYBB protein mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of NPHS1 mRNA]; CYBB protein mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of NPHS2 mRNA]; CYBB protein mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of DES mRNA]; Filipin inhibits the reaction [Homocysteine affects the localization of CYBB protein]; methyl-beta-cyclodextrin inhibits the reaction [Homocysteine affects the localization of CYBB protein]
Homocysteine results in increased expression of CYBB mRNA; Homocysteine results in increased expression of CYBB protein		 CTD PMID:20036696 PMID:20116427 PMID:21647593 NCBI chr  X:13,358,101...13,392,570
Ensembl chr  X:13,359,430...13,392,586 		JBrowse link
G Ddc dopa decarboxylase multiple interactions ISO [Levodopa co-treated with DDC] results in decreased abundance of Homocysteine CTD PMID:11445284 NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression		 ISO Glycine inhibits the reaction [Homocysteine results in increased expression of DDIT3 mRNA]; Glycine inhibits the reaction [Homocysteine results in increased expression of DDIT3 protein]
Homocysteine results in increased expression of DDIT3 mRNA; Homocysteine results in increased expression of DDIT3 protein		 CTD PMID:27064126 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Des desmin multiple interactions
increases expression		 ISO [Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of DES mRNA; acetovanillone inhibits the reaction [Homocysteine results in increased expression of DES mRNA]; acetovanillone inhibits the reaction [Homocysteine results in increased expression of DES protein]; Amitriptyline inhibits the reaction [Homocysteine results in increased expression of DES protein]; CYBB protein mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of DES mRNA]; diphenyleneiodonium inhibits the reaction [Homocysteine results in increased expression of DES mRNA]; diphenyleneiodonium inhibits the reaction [Homocysteine results in increased expression of DES protein]; Filipin inhibits the reaction [Homocysteine results in increased expression of DES mRNA]; Filipin inhibits the reaction [Homocysteine results in increased expression of DES protein]; methyl-beta-cyclodextrin inhibits the reaction [Homocysteine results in increased expression of DES mRNA]; methyl-beta-cyclodextrin inhibits the reaction [Homocysteine results in increased expression of DES protein]
Homocysteine results in increased expression of DES mRNA; Homocysteine results in increased expression of DES protein		 CTD PMID:20036696 PMID:20116427 PMID:23024785 NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699 		JBrowse link
G Dnm1l dynamin 1-like multiple interactions ISO Homocysteine results in increased expression of and results in increased phosphorylation of DNM1L protein; xestospongin C inhibits the reaction [Homocysteine results in increased expression of and results in increased phosphorylation of DNM1L protein] CTD PMID:33751715 NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482 		JBrowse link
G Dnmt1 DNA methyltransferase 1 decreases activity
multiple interactions		 ISO Homocysteine results in decreased activity of DNMT1 protein
DNMT1 protein affects the reaction [Homocysteine results in decreased expression of CCNA1 mRNA]		 CTD PMID:17698632 NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659 		JBrowse link
G Edn1 endothelin 1 multiple interactions
affects expression		 ISO Zeranol inhibits the reaction [Homocysteine affects the expression of EDN1 protein] CTD PMID:16757814 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Egf epidermal growth factor decreases expression EXP Homocysteine results in decreased expression of EGF protein CTD PMID:39357784 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 decreases phosphorylation ISO Homocysteine results in decreased phosphorylation of EIF2AK3 protein CTD PMID:22964297 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation ISO Homocysteine results in increased phosphorylation of EIF2S1 protein CTD PMID:22964297 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225 		JBrowse link
G Ephb6 Eph receptor B6 decreases expression ISO Homocysteine results in decreased expression of EPHB6 mRNA CTD PMID:17320366 NCBI chr 4:70,491,973...70,507,230
Ensembl chr 4:70,491,973...70,507,230 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 decreases phosphorylation ISO Homocysteine results in decreased phosphorylation of ERN1 protein CTD PMID:22964297 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029 		JBrowse link
G Ero1a endoplasmic reticulum oxidoreductase 1 alpha decreases expression ISO Homocysteine results in decreased expression of ERO1A protein CTD PMID:22964297 NCBI chr15:18,495,037...18,530,440
Ensembl chr15:18,492,945...18,530,478 		JBrowse link
G Exosc4 exosome component 4 multiple interactions ISO [Methionine deficiency co-treated with Homocysteine] affects the expression of EXOSC4 protein CTD PMID:17116298 NCBI chr 7:108,047,831...108,050,573
Ensembl chr 7:108,047,831...108,050,573 		JBrowse link
G Gata4 GATA binding protein 4 decreases expression
multiple interactions		 EXP Homocysteine results in decreased expression of GATA4 mRNA; Homocysteine results in decreased expression of GATA4 protein
Particulate Matter promotes the reaction [Homocysteine results in decreased expression of GATA4 protein]		 CTD PMID:27203204 NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636 		JBrowse link
G Gh1 growth hormone 1 decreases abundance ISO GH1 protein results in decreased abundance of Homocysteine CTD PMID:17311540 PMID:17324600 NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078 		JBrowse link
G Gpt glutamic--pyruvic transaminase increases activity
multiple interactions		 EXP Homocysteine results in increased activity of GPT protein
Folic Acid inhibits the reaction [Homocysteine results in increased activity of GPT protein]		 CTD PMID:33788065 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gpx1 glutathione peroxidase 1 decreases activity
decreases expression		 ISO Homocysteine results in decreased activity of GPX1 protein
Homocysteine results in decreased expression of GPX1 protein		 CTD PMID:15734734 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 increases expression EXP Homocysteine analog results in increased expression of GRIN1 protein CTD PMID:20406136 NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603 		JBrowse link
G Gsr glutathione-disulfide reductase decreases expression ISO Homocysteine results in decreased expression of GSR protein CTD PMID:22964297 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Gstm5 glutathione S-transferase, mu 5 multiple interactions ISO [Methionine deficiency co-treated with Homocysteine] affects the expression of GSTM3 protein CTD PMID:17116298 NCBI chr 2:195,531,599...195,534,562
Ensembl chr 2:195,531,495...195,534,553 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO [GSTP1 gene SNP results in increased susceptibility to [Air Pollutants results in increased abundance of Particulate Matter]] which results in increased abundance of Homocysteine CTD PMID:30477822 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G H3f4 H3.4 histone, cluster member multiple interactions ISO Homocysteine promotes the reaction [H3-4 protein modified form binds to CCNA1 promoter] CTD PMID:17698632 NCBI chr10:43,740,702...43,741,262 JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions
increases expression		 ISO Glycine inhibits the reaction [Homocysteine results in increased expression of HSPA5 mRNA]
Homocysteine results in increased expression of HSPA5 mRNA; Homocysteine results in increased expression of HSPA5 protein		 CTD PMID:19960509 PMID:27064126 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 multiple interactions ISO Homocysteine promotes the reaction [HSPA9 protein binds to ITPR1 protein]; Homocysteine promotes the reaction [HSPA9 protein binds to VDAC1 protein] CTD PMID:33751715 NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292 		JBrowse link
G Il10 interleukin 10 increases expression EXP Homocysteine results in increased expression of IL10 mRNA CTD PMID:38729282 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il1b interleukin 1 beta increases expression EXP Homocysteine results in increased expression of IL1B mRNA CTD PMID:38729282 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 increases expression EXP Homocysteine results in increased expression of IL6 mRNA CTD PMID:38729282 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ins1 insulin 1 multiple interactions EXP [Alloxan co-treated with Homocysteine] inhibits the reaction [Glucose results in increased secretion of INS1 protein]; Homocysteine inhibits the reaction [Glucose results in increased secretion of INS1 protein] CTD PMID:27317948 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Isl1 ISL LIM homeobox 1 affects expression
multiple interactions		 ISO Homocysteine affects the expression of ISL1 mRNA
Folic Acid inhibits the reaction [Homocysteine affects the expression of ISL1 mRNA]; Inositol promotes the reaction [Folic Acid inhibits the reaction [Homocysteine affects the expression of ISL1 mRNA]]		 CTD PMID:19638421 NCBI chr 2:48,079,412...48,090,704
Ensembl chr 2:48,080,522...48,095,584 		JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 increases expression
multiple interactions		 ISO Homocysteine results in increased expression of ITPR1 protein
Homocysteine promotes the reaction [HSPA9 protein binds to ITPR1 protein]		 CTD PMID:33751715 NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 increases expression ISO Homocysteine results in increased expression of KEAP1 protein CTD PMID:22964297 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation		 ISO 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; [1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester co-treated with Genistein] inhibits the reaction [Thapsigargin promotes the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]]; Acetylcysteine inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; Folic Acid inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; fulvic acid inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; Genistein inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; Genistein inhibits the reaction [Thapsigargin promotes the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]]; Go 6976 inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; Pertussis Toxin inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; Phorbol 12,13-Dibutyrate inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; Phorbol 12,13-Dibutyrate promotes the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; Staurosporine inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; Tetradecanoylphorbol Acetate promotes the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; Thapsigargin promotes the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]
6-Cyano-7-nitroquinoxaline-2,3-dione inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; 6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; alpha-methyl-4-carboxyphenylglycine inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; Cystine affects the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; Dizocilpine Maleate inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]		 CTD PMID:16251475 PMID:19850060 PMID:25888188 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions
increases phosphorylation		 ISO Acetylcysteine inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK14 protein]; Atorvastatin inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK14 protein]; diphenyleneiodonium inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK14 protein]; NOX4 mutant form inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK14 protein]; SB 203580 inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK14 protein] CTD PMID:19767766 PMID:20018284 PMID:20305681 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; [1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester co-treated with Genistein] inhibits the reaction [Thapsigargin promotes the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]]; Acetylcysteine inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; Folic Acid inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; fulvic acid inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; Genistein inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; Genistein inhibits the reaction [Thapsigargin promotes the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]]; Go 6976 inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; Pertussis Toxin inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; Phorbol 12,13-Dibutyrate inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; Phorbol 12,13-Dibutyrate promotes the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; Staurosporine inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; Tetradecanoylphorbol Acetate promotes the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; Thapsigargin promotes the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]
6-Cyano-7-nitroquinoxaline-2,3-dione inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; 6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; alpha-methyl-4-carboxyphenylglycine inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; Cystine affects the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; Dizocilpine Maleate inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]		 CTD PMID:16251475 PMID:19850060 PMID:25888188 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions		 ISO Homocysteine results in increased phosphorylation of MAPK8 protein
fulvic acid inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK8 protein]		 CTD PMID:25888188 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation
multiple interactions		 ISO Homocysteine results in increased phosphorylation of MAPK9 protein
fulvic acid inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK9 protein]		 CTD PMID:25888188 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mcu mitochondrial calcium uniporter increases expression ISO Homocysteine results in increased expression of MCU protein CTD PMID:33751715 NCBI chr20:27,417,529...27,580,110
Ensembl chr20:27,417,526...27,580,110 		JBrowse link
G Mecp2 methyl CpG binding protein 2 multiple interactions ISO Homocysteine inhibits the reaction [MECP2 protein binds to CCNA1 promoter] CTD PMID:17698632 NCBI chr  X:151,781,177...151,844,687
Ensembl chr  X:151,789,930...151,844,689 		JBrowse link
G Mfn2 mitofusin 2 decreases expression ISO Homocysteine results in decreased expression of MFN2 protein CTD PMID:33751715 NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342 		JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions EXP Dizocilpine Maleate inhibits the reaction [Homocysteine analog results in decreased expression of and results in decreased activity of MMP1 protein]; Homocysteine analog results in decreased expression of and results in decreased activity of MMP1 protein CTD PMID:20406136 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression
increases expression
increases activity		 ISO
EXP		 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Homocysteine results in increased activity of MMP9 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Homocysteine results in increased expression of MMP9 protein]; Acetylcysteine inhibits the reaction [Homocysteine results in increased activity of MMP9 protein]; Acetylcysteine inhibits the reaction [Homocysteine results in increased expression of MMP9 protein]; Staurosporine inhibits the reaction [Homocysteine results in increased activity of MMP9 protein]; Staurosporine inhibits the reaction [Homocysteine results in increased expression of MMP9 protein]
Dizocilpine Maleate inhibits the reaction [Homocysteine analog results in decreased expression of MMP9 protein]
Homocysteine results in increased activity of and results in increased expression of MMP9 protein		 CTD PMID:16251475 PMID:20406136 PMID:22326992 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mt1 metallothionein 1 multiple interactions
decreases expression		 EXP [Folic Acid co-treated with Zinc] inhibits the reaction [Homocysteine results in decreased expression of MT1A mRNA]; Folic Acid inhibits the reaction [Homocysteine results in decreased expression of MT1A mRNA]; Zinc inhibits the reaction [Homocysteine results in decreased expression of MT1A mRNA] CTD PMID:19641857 NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049
Ensembl chr  X:10,826,032...10,827,049 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase increases expression
multiple interactions
affects abundance
decreases methylation
increases abundance
affects metabolic processing		 ISO Homocysteine results in increased expression of MTHFR protein
[MTHFR gene mutant form co-treated with Methotrexate] results in increased abundance of Homocysteine
MTHFR protein affects the abundance of Homocysteine metabolite
Homocysteine inhibits the reaction [Simvastatin results in increased expression of MTHFR protein modified form]; Simvastatin promotes the reaction [Homocysteine results in increased expression of MTHFR protein]
MTHFR protein SNP results in decreased methylation of Homocysteine
MTHFR gene polymorphism results in increased abundance of Homocysteine; MTHFR protein mutant form results in increased abundance of Homocysteine
MTHFR protein affects the metabolism of Homocysteine		 CTD PMID:7647779 PMID:17387702 PMID:18540024 PMID:19204075 PMID:19593106 More... NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797 		JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase affects metabolic processing
multiple interactions
affects binding		 ISO
EXP		 MTR gene polymorphism affects the metabolism of Homocysteine
Homocysteine inhibits the reaction [Folic Acid results in increased activity of MTR protein]
Homocysteine binds to MTR protein		 CTD PMID:17477549 PMID:20532609 PMID:31721048 NCBI chr17:58,219,998...58,308,560
Ensembl chr17:58,220,071...58,304,822 		JBrowse link
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase affects abundance ISO MTRR protein affects the abundance of Homocysteine CTD PMID:17369066 NCBI chr 1:34,866,991...34,899,425
Ensembl chr 1:34,867,089...34,899,425 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 affects localization
increases phosphorylation
multiple interactions		 ISO Homocysteine affects the localization of NCF1 protein
Homocysteine results in increased phosphorylation of NCF1 protein
Filipin inhibits the reaction [Homocysteine affects the localization of NCF1 protein]; methyl-beta-cyclodextrin inhibits the reaction [Homocysteine affects the localization of NCF1 protein]
Folic Acid inhibits the reaction [Homocysteine results in increased phosphorylation of NCF1 protein]; Homocysteine promotes the reaction [NCF1 protein results in increased abundance of Reactive Oxygen Species]; Homocysteine results in increased localization of and results in increased activity of NCF1 protein		 CTD PMID:16845898 PMID:17586618 PMID:20036696 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects localization
decreases expression
multiple interactions
increases expression		 ISO
EXP		 Homocysteine affects the localization of NFE2L2 protein modified form
Homocysteine results in decreased expression of NFE2L2 protein
acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [Homocysteine results in decreased expression of NFE2L2 protein]; Homocysteine results in decreased phosphorylation of and results in decreased expression of NFE2L2 protein; L 709049 inhibits the reaction [Homocysteine results in decreased expression of NFE2L2 protein]; N-(4-fluorophenylsulfonyl)-L-valyl-L-leucinal inhibits the reaction [Homocysteine results in decreased phosphorylation of and results in decreased expression of NFE2L2 protein]
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Homocysteine results in decreased phosphorylation of and results in decreased expression of NFE2L2 protein]; Homocysteine results in decreased phosphorylation of and results in decreased expression of NFE2L2 protein
Homocysteine results in increased expression of NFE2L2 mRNA		 CTD PMID:22964297 PMID:38729282 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
increases degradation		 ISO [Adenosine co-treated with Homocysteine] affects the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]; [Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA]; [Adenosine co-treated with Homocysteine] results in decreased expression of NFKBIA mRNA; [Homocysteine results in increased expression of CCL2 protein] which results in increased phosphorylation of NFKBIA protein; [Homocysteine results in increased expression of CCL2 protein] which results in increased reduction of NFKBIA mRNA; acetovanillone inhibits the reaction [Homocysteine results in increased phosphorylation of and results in increased activity of NFKBIA protein]; Folic Acid inhibits the reaction [Homocysteine results in increased phosphorylation of and results in increased activity of NFKBIA protein]; Homocysteine results in increased phosphorylation of and results in increased activity of NFKBIA protein
Homocysteine results in increased degradation of NFKBIA protein		 CTD PMID:11356643 PMID:16845898 PMID:17586618 PMID:24224954 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nfkbib NFKB inhibitor beta increases degradation ISO Homocysteine results in increased degradation of NFKBIB protein CTD PMID:17586618 NCBI chr 1:84,046,292...84,053,862
Ensembl chr 1:84,046,295...84,053,862 		JBrowse link
G Nkx2-5 NK2 homeobox 5 multiple interactions
decreases expression		 EXP Particulate Matter promotes the reaction [Homocysteine results in decreased expression of NKX2-5 protein]
Homocysteine results in decreased expression of NKX2-5 mRNA; Homocysteine results in decreased expression of NKX2-5 protein		 CTD PMID:27203204 NCBI chr10:16,340,428...16,347,004
Ensembl chr10:16,344,159...16,346,934 		JBrowse link
G Nlrc3 NLR family, CARD domain containing 3 multiple interactions
increases expression		 ISO [Folic Acid deficiency results in increased abundance of Homocysteine] promotes the reaction [NLRC3 protein binds to PYCARD protein binds to CASP1 protein]; CASP1 protein affects the reaction [Homocysteine promotes the reaction [NLRC3 protein binds to PYCARD protein binds to CASP1 protein]]; Homocysteine promotes the reaction [NLRC3 protein binds to PYCARD protein binds to CASP1 protein]; PYCARD protein affects the reaction [Homocysteine promotes the reaction [NLRC3 protein binds to PYCARD protein binds to CASP1 protein]]
Homocysteine results in increased expression of NLRC3 mRNA		 CTD PMID:22647887 NCBI chr10:11,551,378...11,585,027
Ensembl chr10:11,551,356...11,584,398 		JBrowse link
G Nos2 nitric oxide synthase 2 increases methylation
multiple interactions
increases expression		 ISO Homocysteine results in increased methylation of NOS2 promoter
[Homocysteine results in increased methylation of NOS2 promoter] which results in decreased expression of NOS2 mRNA; Clofibrate inhibits the reaction [Homocysteine results in increased methylation of NOS2 promoter]; pioglitazone inhibits the reaction [Homocysteine results in increased methylation of NOS2 promoter]
Homocysteine affects the reaction [Simvastatin results in increased expression of NOS2 protein]; Simvastatin promotes the reaction [Homocysteine results in increased expression of NOS2 mRNA]		 CTD PMID:17492134 PMID:18540024 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
decreases expression
decreases phosphorylation		 ISO Folic Acid inhibits the reaction [Homocysteine results in decreased expression of and results in decreased activity of NOS3 protein]; Homocysteine results in decreased expression of and results in decreased activity of NOS3 protein; Zeranol inhibits the reaction [Homocysteine results in decreased expression of NOS3 protein]
Atorvastatin inhibits the reaction [Homocysteine results in decreased expression of NOS3 mRNA]; Atorvastatin inhibits the reaction [Homocysteine results in decreased phosphorylation of NOS3 protein]
Homocysteine results in decreased expression of NOS3 mRNA; Homocysteine results in decreased expression of NOS3 protein		 CTD PMID:16757814 PMID:17357445 PMID:20305681 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions
increases response to substance
increases expression		 ISO Atorvastatin inhibits the reaction [Homocysteine results in increased expression of NOX4 mRNA]; NOX4 mutant form inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK14 protein]
NOX4 results in increased susceptibility to Homocysteine		 CTD PMID:20018284 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406 		JBrowse link
G Nphs1 NPHS1 adhesion molecule, nephrin multiple interactions
decreases expression		 ISO [Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of NPHS1 mRNA; acetovanillone inhibits the reaction [Homocysteine results in decreased expression of NPHS1 mRNA]; acetovanillone inhibits the reaction [Homocysteine results in decreased expression of NPHS1 protein]; CYBB protein mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of NPHS1 mRNA]; diphenyleneiodonium inhibits the reaction [Homocysteine results in decreased expression of NPHS1 mRNA]; diphenyleneiodonium inhibits the reaction [Homocysteine results in decreased expression of NPHS1 protein]; Filipin inhibits the reaction [Homocysteine results in decreased expression of NPHS1 mRNA]; Filipin inhibits the reaction [Homocysteine results in decreased expression of NPHS1 protein]; methyl-beta-cyclodextrin inhibits the reaction [Homocysteine results in decreased expression of NPHS1 mRNA]; methyl-beta-cyclodextrin inhibits the reaction [Homocysteine results in decreased expression of NPHS1 protein]
Homocysteine results in decreased expression of NPHS1 mRNA; Homocysteine results in decreased expression of NPHS1 protein		 CTD PMID:20036696 PMID:20116427 NCBI chr 1:85,720,812...85,749,079
Ensembl chr 1:85,720,812...85,749,078 		JBrowse link
G Nphs2 NPHS2 stomatin family member, podocin multiple interactions
decreases expression		 ISO [Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of NPHS2 mRNA; acetovanillone inhibits the reaction [Homocysteine results in decreased expression of NPHS2 mRNA]; acetovanillone inhibits the reaction [Homocysteine results in decreased expression of NPHS2 protein]; Amitriptyline inhibits the reaction [Homocysteine results in decreased expression of NPHS2 protein]; CYBB protein mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of NPHS2 mRNA]; diphenyleneiodonium inhibits the reaction [Homocysteine results in decreased expression of NPHS2 mRNA]; diphenyleneiodonium inhibits the reaction [Homocysteine results in decreased expression of NPHS2 protein]; Filipin inhibits the reaction [Homocysteine results in decreased expression of NPHS2 mRNA]; Filipin inhibits the reaction [Homocysteine results in decreased expression of NPHS2 protein]; methyl-beta-cyclodextrin inhibits the reaction [Homocysteine results in decreased expression of NPHS2 mRNA]; methyl-beta-cyclodextrin inhibits the reaction [Homocysteine results in decreased expression of NPHS2 protein]
Homocysteine results in decreased expression of NPHS2 mRNA; Homocysteine results in decreased expression of NPHS2 protein		 CTD PMID:20036696 PMID:20116427 PMID:23024785 NCBI chr13:68,448,720...68,461,312
Ensembl chr13:68,448,926...68,461,313 		JBrowse link
G Nt5e 5' nucleotidase, ecto affects activity ISO Homocysteine affects the activity of NT5E protein CTD PMID:24055814 NCBI chr 8:89,271,046...89,314,918
Ensembl chr 8:89,270,696...89,314,881 		JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 multiple interactions
decreases expression		 EXP Rivastigmine inhibits the reaction [Homocysteine results in decreased expression of NTRK2 protein] CTD PMID:39357784 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136 		JBrowse link
G Pacs2 phosphofurin acidic cluster sorting protein 2 increases expression ISO Homocysteine results in increased expression of PACS2 protein CTD PMID:33751715 NCBI chr 6:132,096,992...132,156,702
Ensembl chr 6:132,096,901...132,154,583 		JBrowse link
G Pon1 paraoxonase 1 multiple interactions ISO [Methionine results in increased abundance of Homocysteine] which results in decreased activity of PON1 protein; [resveratrol results in increased abundance of Homocysteine] which results in decreased activity of PON1 protein CTD PMID:19028542 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360 		JBrowse link
G Prdx6 peroxiredoxin 6 multiple interactions ISO [Methionine deficiency co-treated with Homocysteine] affects the expression of PRDX6 protein CTD PMID:17116298 NCBI chr13:73,528,746...73,539,295
Ensembl chr13:73,528,210...73,539,355 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression		 ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Homocysteine results in increased expression of PTGS2 mRNA]; fulvic acid inhibits the reaction [Homocysteine promotes the reaction [RELA protein binds to PTGS2 promoter]]; fulvic acid inhibits the reaction [Homocysteine results in increased expression of PTGS2 mRNA]; Homocysteine promotes the reaction [RELA protein binds to PTGS2 promoter]; pyrazolanthrone inhibits the reaction [Homocysteine results in increased expression of PTGS2 mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [Homocysteine results in increased expression of PTGS2 mRNA]; SN50 peptide inhibits the reaction [Homocysteine results in increased expression of PTGS2 mRNA] CTD PMID:25888188 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Pycard PYD and CARD domain containing multiple interactions
increases expression		 ISO [Folic Acid deficiency results in increased abundance of Homocysteine] promotes the reaction [NLRC3 protein binds to PYCARD protein binds to CASP1 protein]; CASP1 protein affects the reaction [Homocysteine promotes the reaction [NLRC3 protein binds to PYCARD protein binds to CASP1 protein]]; Homocysteine promotes the reaction [NLRC3 protein binds to PYCARD protein binds to CASP1 protein]; PYCARD protein affects the reaction [Homocysteine promotes the reaction [NLRC3 protein binds to PYCARD protein binds to CASP1 protein]]; PYCARD protein affects the reaction [Homocysteine results in decreased secretion of VEGFA protein]; PYCARD protein affects the reaction [Homocysteine results in increased activity of CASP1 protein]
Homocysteine results in increased expression of PYCARD mRNA		 CTD PMID:22647887 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955 		JBrowse link
G Rab1b RAB1B, member RAS oncogene family multiple interactions ISO [Methionine deficiency co-treated with Homocysteine] affects the expression of RAB1B protein CTD PMID:17116298 NCBI chr 1:202,405,759...202,413,850
Ensembl chr 1:202,405,759...202,413,868
Ensembl chr  X:202,405,759...202,413,868 		JBrowse link
G Rab9a RAB9A, member RAS oncogene family multiple interactions ISO [Methionine deficiency co-treated with Homocysteine] affects the expression of RAB9A protein CTD PMID:17116298 NCBI chr  X:27,955,552...28,009,870
Ensembl chr  X:27,952,204...28,001,622 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases expression
increases localization
increases activity		 ISO
EXP		 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Homocysteine results in increased activity of RELA protein]; [Adenosine co-treated with Homocysteine] affects the reaction [TNF protein affects the localization of RELA protein modified form]; [Adenosine co-treated with Homocysteine] affects the reaction [TNF protein results in increased phosphorylation of RELA protein]; fulvic acid inhibits the reaction [Homocysteine promotes the reaction [RELA protein binds to PTGS2 promoter]]; Homocysteine promotes the reaction [RELA protein binds to PTGS2 promoter]; pyrazolanthrone inhibits the reaction [Homocysteine results in increased activity of RELA protein]
Homocysteine results in increased expression of RELA protein
Homocysteine inhibits the reaction [Simvastatin results in decreased expression of RELA protein]
Homocysteine results in increased localization of RELA protein		 CTD PMID:17586618 PMID:18540024 PMID:24224954 PMID:25888188 PMID:38729282 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 multiple interactions ISO [Adenosine co-treated with Homocysteine co-treated with TNF protein] results in increased cleavage of RIPK1 protein CTD PMID:24224954 NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824 		JBrowse link
G S100a4 S100 calcium-binding protein A4 multiple interactions
increases expression		 ISO [Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of S100A4 mRNA; [Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of S100A4 protein; acetovanillone inhibits the reaction [Homocysteine results in increased expression of S100A4 protein]; CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of S100A4 mRNA]; CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of S100A4 protein]; CYBB mutant form inhibits the reaction [Homocysteine results in increased expression of S100A4 protein]
Homocysteine results in increased expression of S100A4 mRNA; Homocysteine results in increased expression of S100A4 protein		 CTD PMID:21647593 NCBI chr 2:176,090,951...176,093,258
Ensembl chr 2:176,091,804...176,093,254 		JBrowse link
G Slc46a1 solute carrier family 46 member 1 affects abundance ISO SLC46A1 protein affects the abundance of Homocysteine metabolite CTD PMID:19204075 NCBI chr10:63,361,504...63,367,940
Ensembl chr10:63,361,486...63,368,848 		JBrowse link
G Sod1 superoxide dismutase 1 increases expression EXP Homocysteine results in increased expression of SOD1 protein CTD PMID:17485853 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO [SOD2 gene SNP results in increased susceptibility to [Air Pollutants results in increased abundance of Particulate Matter]] which results in increased abundance of Homocysteine CTD PMID:30477822 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Ssr4 signal sequence receptor subunit 4 multiple interactions ISO [Methionine deficiency co-treated with Homocysteine] affects the expression of SSR4 protein CTD PMID:17116298 NCBI chr  X:151,524,191...151,528,218
Ensembl chr  X:151,524,009...151,528,202 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions
increases expression		 EXP Dizocilpine Maleate inhibits the reaction [Homocysteine analog results in increased expression of TIMP1 mRNA]; Dizocilpine Maleate inhibits the reaction [Homocysteine analog results in increased expression of TIMP1 protein]
Homocysteine analog results in increased expression of TIMP1 mRNA; Homocysteine analog results in increased expression of TIMP1 protein		 CTD PMID:20406136 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Tjp1 tight junction protein 1 multiple interactions
decreases expression		 ISO [Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of TJP1 mRNA; acetovanillone inhibits the reaction [Homocysteine results in decreased expression of TJP1 protein]; CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of TJP1 mRNA]; CYBB mutant form inhibits the reaction [Homocysteine results in decreased expression of TJP1 protein]
Homocysteine results in decreased expression of TJP1 mRNA; Homocysteine results in decreased expression of TJP1 protein		 CTD PMID:21647593 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432 		JBrowse link
G Tlr2 toll-like receptor 2 decreases expression EXP Homocysteine results in decreased expression of TLR2 mRNA CTD PMID:38729282 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression		 ISO
EXP		 [Adenosine co-treated with Homocysteine co-treated with TNF protein] results in increased cleavage of RIPK1 protein; [Adenosine co-treated with Homocysteine] affects the reaction [TNF protein affects the localization of RELA protein modified form]; [Adenosine co-treated with Homocysteine] affects the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]; [Adenosine co-treated with Homocysteine] affects the reaction [TNF protein results in increased phosphorylation of RELA protein]; [Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; [Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA]; [Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of TNFAIP3 mRNA]; [Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein]; [Adenosine co-treated with Homocysteine] results in increased susceptibility to TNF protein
Homocysteine results in increased expression of TNF protein		 CTD PMID:24224954 PMID:27203204 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfaip3 TNF alpha induced protein 3 multiple interactions ISO [Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of TNFAIP3 mRNA]; [Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein]; [Adenosine co-treated with Homocysteine] results in decreased expression of TNFAIP3 mRNA; [Adenosine co-treated with Homocysteine] results in decreased expression of TNFAIP3 protein CTD PMID:24224954 NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282 		JBrowse link
G Tp53 tumor protein p53 increases phosphorylation
affects expression
multiple interactions		 EXP
ISO		 Homocysteine results in increased phosphorylation of TP53 protein
Homocysteine affects the expression of TP53 mRNA; Homocysteine affects the expression of TP53 protein
Folic Acid affects the reaction [Homocysteine affects the expression of TP53 mRNA]; Folic Acid affects the reaction [Homocysteine affects the expression of TP53 protein]		 CTD PMID:13679428 PMID:29250709 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Vbp1 VHL binding protein 1 multiple interactions ISO [Methionine deficiency co-treated with Homocysteine] affects the expression of VBP1 protein CTD PMID:17116298
G Vcam1 vascular cell adhesion molecule 1 multiple interactions
increases expression		 ISO 3,4-dihydroxyphenylethanol inhibits the reaction [Homocysteine results in increased expression of VCAM1 protein]; resveratrol inhibits the reaction [Homocysteine results in increased expression of VCAM1 protein]
Homocysteine results in increased expression of VCAM1 mRNA; Homocysteine results in increased expression of VCAM1 protein		 CTD PMID:17586618 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
G Vdac1 voltage-dependent anion channel 1 increases expression
multiple interactions		 ISO Homocysteine results in increased expression of VDAC1 protein
Homocysteine promotes the reaction [HSPA9 protein binds to VDAC1 protein]		 CTD PMID:33751715 NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
decreases expression
increases expression
decreases secretion		 ISO
EXP		 Amitriptyline inhibits the reaction [Homocysteine results in decreased secretion of VEGFA protein]; CASP1 protein affects the reaction [Homocysteine results in decreased secretion of VEGFA protein]; CYBB protein affects the reaction [Homocysteine results in decreased secretion of VEGFA protein]; diphenyleneiodonium inhibits the reaction [Homocysteine results in decreased secretion of VEGFA protein]; Homocysteine results in decreased expression of and results in decreased secretion of VEGFA protein; PYCARD protein affects the reaction [Homocysteine results in decreased secretion of VEGFA protein]
Homocysteine results in decreased expression of VEGFA protein
Rivastigmine inhibits the reaction [Homocysteine results in decreased expression of VEGFA protein]
Homocysteine results in increased expression of VEGFA protein
Homocysteine results in decreased expression of VEGFA mRNA		 CTD PMID:17485853 PMID:20116427 PMID:22647887 PMID:23024785 PMID:39357784 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Vim vimentin increases expression EXP Homocysteine results in increased expression of VIM protein CTD PMID:17485853 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
G Vps29 VPS29 retromer complex component multiple interactions ISO [Methionine deficiency co-treated with Homocysteine] affects the expression of VPS29 protein CTD PMID:17116298 NCBI chr12:34,208,911...34,217,977
Ensembl chr12:34,207,263...34,217,964 		JBrowse link
G Wnt5a Wnt family member 5A decreases expression ISO Homocysteine results in decreased expression of WNT5A mRNA CTD PMID:17320366 NCBI chr16:3,697,032...3,718,230
Ensembl chr16:3,697,032...3,718,234 		JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions
decreases expression
increases expression
increases splicing		 ISO Glycine affects the reaction [Homocysteine results in increased splicing of XBP1 mRNA]
Homocysteine results in decreased expression of XBP1 protein
Homocysteine results in increased expression of XBP1 mRNA alternative form		 CTD PMID:19960509 PMID:22964297 PMID:27064126 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
homocysteic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions EXP [homocysteic acid co-treated with GW 506033X] results in increased phosphorylation of EIF2S1 protein CTD PMID:19046382 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225 		JBrowse link
G Hsf1 heat shock transcription factor 1 decreases expression EXP homocysteic acid results in decreased expression of HSF1 protein CTD PMID:24478344 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011 		JBrowse link
G Sp1 Sp1 transcription factor increases activity
multiple interactions		 ISO homocysteic acid results in increased activity of SP1 protein
mithramycin A inhibits the reaction [homocysteic acid results in increased activity of SP1 protein]		 CTD PMID:11261509 NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961 		JBrowse link
G Sp3 Sp3 transcription factor multiple interactions
increases activity		 ISO mithramycin A inhibits the reaction [homocysteic acid results in increased activity of SP3 protein] CTD PMID:11261509 NCBI chr 3:57,811,855...57,857,150
Ensembl chr 3:57,812,075...57,860,342 		JBrowse link
S-adenosyl-L-homocysteine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahcy adenosylhomocysteinase increases hydrolysis ISO AHCY results in increased hydrolysis of S-Adenosylhomocysteine CTD PMID:26974671 NCBI chr 3:143,569,134...143,584,359
Ensembl chr 3:143,569,094...143,584,393 		JBrowse link
G Ahr aryl hydrocarbon receptor increases abundance
multiple interactions		 ISO AHR protein results in increased abundance of S-Adenosylhomocysteine
PEMT protein promotes the reaction [AHR protein results in increased abundance of S-Adenosylhomocysteine]		 CTD PMID:29416063 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Alas2 5'-aminolevulinate synthase 2 multiple interactions ISO [S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of ALAS2 mRNA; catechol inhibits the reaction [[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of ALAS2 mRNA] CTD PMID:24141029 NCBI chr  X:19,463,146...19,486,526
Ensembl chr  X:19,463,171...19,486,519 		JBrowse link
G App amyloid beta precursor protein increases expression
decreases methylation
multiple interactions		 ISO S-Adenosylhomocysteine results in increased expression of APP protein
S-Adenosylhomocysteine results in decreased methylation of APP promoter
Betaine inhibits the reaction [S-Adenosylhomocysteine results in decreased methylation of APP promoter]; Betaine inhibits the reaction [S-Adenosylhomocysteine results in increased expression of and results in increased cleavage of APP protein]; S-Adenosylhomocysteine results in increased expression of and results in increased cleavage of APP protein		 CTD PMID:19635394 PMID:22064374 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Atp7b ATPase copper transporting beta increases abundance ISO ATP7B protein mutant form results in increased abundance of S-Adenosylhomocysteine CTD PMID:22945834 NCBI chr16:69,952,286...70,024,404
Ensembl chr16:69,951,778...70,023,636 		JBrowse link
G Bace1 beta-secretase 1 increases expression ISO S-Adenosylhomocysteine results in increased expression of BACE1 protein CTD PMID:19635394 NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876 		JBrowse link
G Carm1 coactivator-associated arginine methyltransferase 1 decreases activity ISO S-Adenosylhomocysteine results in decreased activity of CARM1 protein CTD PMID:33577917 NCBI chr 8:20,097,262...20,141,950
Ensembl chr 8:20,097,254...20,147,689 		JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression ISO S-Adenosylhomocysteine results in decreased expression of COL1A1 mRNA CTD PMID:15983038 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Col1a2 collagen type I alpha 2 chain decreases expression ISO S-Adenosylhomocysteine results in decreased expression of COL1A2 mRNA CTD PMID:15983038 NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867 		JBrowse link
G Comt catechol-O-methyltransferase decreases activity EXP S-Adenosylhomocysteine results in decreased activity of COMT protein CTD PMID:10064789 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Dnmt1 DNA methyltransferase 1 decreases activity
multiple interactions		 ISO S-Adenosylhomocysteine results in decreased activity of DNMT1 protein
S-Adenosylhomocysteine inhibits the reaction [DNMT1 protein binds to OGG1 promoter]		 CTD PMID:16037419 PMID:22064374 NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659 		JBrowse link
G Fgf19 fibroblast growth factor 19 decreases abundance ISO FGF19 protein results in decreased abundance of S-Adenosylhomocysteine CTD PMID:29416063 NCBI chr 1:200,056,526...200,060,980
Ensembl chr 1:200,056,644...200,060,287 		JBrowse link
G Hbb hemoglobin subunit beta multiple interactions ISO [S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HBB mRNA; catechol inhibits the reaction [[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HBB mRNA] CTD PMID:24141029 NCBI chr 1:158,250,421...158,251,832
Ensembl chr 1:158,120,200...158,252,012 		JBrowse link
G Hmbs hydroxymethylbilane synthase multiple interactions ISO [S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HMBS mRNA; catechol inhibits the reaction [[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HMBS mRNA] CTD PMID:24141029 NCBI chr 8:44,673,554...44,680,950
Ensembl chr 8:44,673,554...44,680,957 		JBrowse link
G Mmp2 matrix metallopeptidase 2 increases expression
multiple interactions		 ISO
EXP		 S-Adenosylhomocysteine results in increased expression of MMP2 mRNA; S-Adenosylhomocysteine results in increased expression of MMP2 protein
S-Adenosylhomocysteine promotes the reaction [SP1 protein binds to MMP2 promoter]
U 0126 inhibits the reaction [S-Adenosylhomocysteine results in increased expression of MMP2 protein]		 CTD PMID:19770485 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Nfkbia NFKB inhibitor alpha decreases expression EXP S-Adenosylhomocysteine results in decreased expression of NFKBIA protein CTD PMID:19770485 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 decreases abundance ISO NR0B2 protein results in decreased abundance of S-Adenosylhomocysteine CTD PMID:29416063 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609 		JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase multiple interactions
decreases methylation
decreases expression		 ISO Betaine inhibits the reaction [S-Adenosylhomocysteine results in decreased expression of OGG1 protein]; Betaine inhibits the reaction [S-Adenosylhomocysteine results in decreased methylation of OGG1 promoter]; S-Adenosylhomocysteine inhibits the reaction [DNMT1 protein binds to OGG1 promoter]
S-Adenosylhomocysteine results in decreased expression of OGG1 mRNA; S-Adenosylhomocysteine results in decreased expression of OGG1 protein		 CTD PMID:22064374 NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766 		JBrowse link
G Pemt phosphatidylethanolamine N-methyltransferase multiple interactions ISO PEMT protein promotes the reaction [AHR protein results in increased abundance of S-Adenosylhomocysteine] CTD PMID:29416063 NCBI chr10:44,775,910...44,849,990
Ensembl chr10:44,775,911...44,850,013 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO S-Adenosylhomocysteine results in increased expression of PPARGC1A mRNA CTD PMID:23056435 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Prmt1 protein arginine methyltransferase 1 decreases activity ISO S-Adenosylhomocysteine results in decreased activity of PRMT1 protein CTD PMID:33577917 NCBI chr 1:95,458,853...95,468,176
Ensembl chr 1:95,458,850...95,468,345 		JBrowse link
G Prmt5 protein arginine methyltransferase 5 decreases activity ISO S-Adenosylhomocysteine results in decreased activity of PRMT5 protein CTD PMID:33577917 NCBI chr15:27,968,893...27,978,291
Ensembl chr15:27,968,910...27,978,296 		JBrowse link
G Prmt6 protein arginine methyltransferase 6 decreases activity ISO S-Adenosylhomocysteine results in decreased activity of PRMT6 protein CTD PMID:33577917 NCBI chr 2:197,927,750...197,932,760
Ensembl chr 2:197,927,220...197,933,648 		JBrowse link
G Prmt7 protein arginine methyltransferase 7 decreases activity ISO S-Adenosylhomocysteine results in decreased activity of PRMT7 protein CTD PMID:33577917 NCBI chr19:34,110,724...34,161,531
Ensembl chr19:34,110,747...34,162,577 		JBrowse link
G Psen1 presenilin 1 multiple interactions
decreases methylation
increases expression		 ISO Betaine inhibits the reaction [S-Adenosylhomocysteine results in decreased methylation of PSEN1 promoter]
S-Adenosylhomocysteine results in increased expression of PSEN1 protein		 CTD PMID:19635394 NCBI chr 6:103,323,052...103,375,088
Ensembl chr 6:103,323,120...103,371,650 		JBrowse link
G Slc19a1 solute carrier family 19 member 1 affects abundance ISO SLC19A1 protein affects the abundance of S-Adenosylhomocysteine CTD PMID:15705887 NCBI chr20:11,584,410...11,602,429
Ensembl chr20:11,584,411...11,601,972 		JBrowse link
G Sp1 Sp1 transcription factor multiple interactions EXP S-Adenosylhomocysteine promotes the reaction [SP1 protein binds to MMP2 promoter] CTD PMID:19770485 NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961 		JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 decreases expression ISO S-Adenosylhomocysteine results in decreased expression of TIMP2 protein CTD PMID:19770485 NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19867
    role 19837
      biological role 19835
        biochemical role 19552
          metabolite 19539
            fundamental metabolite 14528
              homocysteine 139
                L-homocysteine + 0
                homocysteic acid + 4
                homocysteine derivative + 28
Path 2
Term Annotations click to browse term
  CHEBI ontology 19867
    subatomic particle 19865
      composite particle 19865
        hadron 19865
          baryon 19865
            nucleon 19865
              atomic nucleus 19865
                atom 19865
                  main group element atom 19803
                    main group molecular entity 19803
                      s-block molecular entity 19638
                        hydrogen molecular entity 19620
                          hydrides 19141
                            inorganic hydride 18156
                              pnictogen hydride 18146
                                nitrogen hydride 18059
                                  azane 17868
                                    ammonia 17867
                                      organic amino compound 17867
                                        amino acid 16057
                                          non-proteinogenic amino acid 3997
                                            non-proteinogenic alpha-amino acid 3803
                                              homocysteines 422
                                                homocysteine 139
                                                  L-homocysteine + 0
                                                  homocysteic acid + 4
                                                  homocysteine derivative + 28
paths to the root