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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:geranyl diphosphate
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Accession:CHEBI:17211 term browser browse the term
Definition:The diphosphate of the polyprenol compound geraniol.
Synonyms:related_synonym: (2E)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate;   Formula=C10H20O7P2;   InChI=1S/C10H20O7P2/c1-9(2)5-4-6-10(3)7-8-16-19(14,15)17-18(11,12)13/h5,7H,4,6,8H2,1-3H3,(H,14,15)(H2,11,12,13)/b10-7+;   InChIKey=GVVPGTZRZFNKDS-JXMROGBWSA-N;   SMILES=CC(C)=CCC\\C(C)=C\\COP(O)(=O)OP(O)(O)=O;   geranyl pyrophosphate
 alt_id: CHEBI:14299;   CHEBI:24223;   CHEBI:42877;   CHEBI:5332
 xref: Beilstein:1915690;   CAS:763-10-0;   DrugBank:DB02552;   KEGG:C00341;   KNApSAcK:C00000846;   LIPID_MAPS_instance:LMPR0102010001
 xref_mesh: MESH:C015234
 xref: PDBeChem:GPP;   PMID:19049370;   PMID:19856009;   PMID:23607888;   PMID:7753173;   Reaxys:1915690
 cyclic_relationship: is_conjugate_acid_of CHEBI:58057


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geranyl diphosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions
increases abundance		 ISO [geranylgeraniol co-treated with geranyl pyrophosphate] results in decreased expression of HMGCR protein; Lovastatin inhibits the reaction [HMGCR protein results in increased abundance of geranyl diphosphate] CTD PMID:19819230 PMID:19856009 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703 		JBrowse link
G Mvk mevalonate kinase decreases activity
multiple interactions		 ISO geranyl diphosphate results in decreased activity of MVK protein
geranyl diphosphate inhibits the reaction [MVK protein results in increased hydrolysis of Adenosine Triphosphate]; geranyl diphosphate inhibits the reaction [MVK protein results in increased phosphorylation of Mevalonic Acid]		 CTD PMID:9392419 NCBI chr12:42,141,391...42,158,893
Ensembl chr12:42,141,384...42,158,882 		JBrowse link
G Rap1a RAP1A, member of RAS oncogene family multiple interactions ISO [geranylgeraniol co-treated with geranyl pyrophosphate] results in decreased expression of RAP1A protein modified form CTD PMID:19819230 NCBI chr 2:193,208,631...193,286,513
Ensembl chr 2:193,208,635...193,286,501 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19922
    role 19894
      application 19735
        fragrance 1016
          geraniol 399
            geranyl diphosphate 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19922
    subatomic particle 19892
      composite particle 19892
        hadron 19920
          baryon 19892
            nucleon 19920
              atomic nucleus 19892
                atom 19892
                  main group element atom 19866
                    p-block element atom 19866
                      chalcogen 19587
                        oxygen atom 19587
                          oxygen molecular entity 19587
                            hydroxides 19390
                              oxoacid 18821
                                pnictogen oxoacid 14983
                                  phosphorus oxoacid 14581
                                    phosphoric acids 13915
                                      phosphoric acid 13923
                                        phosphoric acid derivative 13828
                                          phosphate 13820
                                            organic phosphate 13820
                                              phospholipid 317
                                                isoprenoid phosphate 75
                                                  prenol phosphate 75
                                                    polyprenol phosphate 66
                                                      polyprenyl diphosphate 66
                                                        geranyl diphosphate 3
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