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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:L-proline
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Accession:CHEBI:17203 term browser browse the term
Definition:Pyrrolidine in which the pro-S hydrogen at position 2 is substituted by a carboxylic acid group. L-Proline is the only one of the twenty DNA-encoded amino acids which has a secondary amino group alpha to the carboxyl group. It is an essential component of collagen and is important for proper functioning of joints and tendons. It also helps maintain and strengthen heart muscles.
Synonyms:related_synonym: (2S)-pyrrolidine-2-carboxylic acid;   (S)-2-carboxypyrrolidine;   (S)-2-pyrrolidinecarboxylic acid;   (S)-Proline;   (S)-pyrrolidine-2-carboxylic acid;   2-Pyrrolidinecarboxylic acid;   Formula=C5H9NO2;   InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1;   InChIKey=ONIBWKKTOPOVIA-BYPYZUCNSA-N;   L-Prolin;   L-alpha-pyrrolidinecarboxylic acid;   L-pyrrolidine-2-carboxylic acid;   P;   SMILES=OC(=O)[C@@H]1CCCN1;   prolina;   proline;   prolinum
 alt_id: CHEBI:13154;   CHEBI:184637;   CHEBI:21373;   CHEBI:42067;   CHEBI:45040;   CHEBI:45100;   CHEBI:45159;   CHEBI:6286
 xref: Beilstein:80810;   CAS:147-85-3;   DrugBank:DB00172;   Drug_Central:4125;   Gmelin:50152;   HMDB:HMDB0000162;   KEGG:C00148;   KEGG:D00035;   KNApSAcK:C00001388;   MetaCyc:PRO;   PDBeChem:PRO;   PMID:11076505;   PMID:12770004;   PMID:14975886;   PMID:15576824;   PMID:15838615;   PMID:15894682;   PMID:15973048;   PMID:16033917;   PMID:16190672;   PMID:16501220;   PMID:16656443;   PMID:16657874;   PMID:16668324;   PMID:17127472;   PMID:17608428;   PMID:18551589;   PMID:18802692;   PMID:18973300;   PMID:19215998;   PMID:19580280;   PMID:19656302;   PMID:19688381;   PMID:19811425;   PMID:22139509;   PMID:22201772;   PMID:22451406;   PMID:22475019;   PMID:22482728;   PMID:22491679;   PMID:22770225;   Reaxys:80810;   Wikipedia:L-proline
 cyclic_relationship: is_conjugate_acid_of CHEBI:32862;   is_conjugate_base_of CHEBI:32864;   is_enantiomer_of CHEBI:16313;   is_tautomer_of CHEBI:60039


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5-oxo-L-proline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dek DEK proto-oncogene multiple interactions ISO DEK protein results in decreased chemical synthesis of and results in increased uptake of Pyrrolidonecarboxylic Acid CTD PMID:28558019 NCBI chr17:17,580,804...17,602,825
Ensembl chr17:17,580,843...17,602,808 		JBrowse link
G Ins2 insulin 2 multiple interactions ISO [1-Methyl-3-isobutylxanthine co-treated with butylbenzyl phthalate co-treated with INS protein] results in increased abundance of Pyrrolidonecarboxylic Acid analog CTD PMID:26820058 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
captopril term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme multiple interactions
decreases activity		 EXP
ISO		 Captopril inhibits the reaction [Pregabalin results in increased expression of ACE protein]
Captopril inhibits the reaction [AGT protein results in increased expression of ACE mRNA]; Captopril inhibits the reaction [AGT protein results in increased expression of ACE protein]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of ACE mRNA]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of ACE protein]
Captopril results in decreased activity of ACE protein		 CTD PMID:26851370 PMID:31629013 PMID:33007385 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131 		JBrowse link
G Ace2 angiotensin converting enzyme 2 decreases response to substance
multiple interactions		 ISO
EXP		 ACE2 gene SNP results in decreased susceptibility to Captopril
Captopril inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]; Captopril inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]; Captopril inhibits the reaction [Silicon Dioxide results in decreased expression of ACE2 mRNA]; Captopril inhibits the reaction [Silicon Dioxide results in decreased expression of ACE2 protein]
Captopril inhibits the reaction [Pregabalin results in decreased expression of ACE2 protein]		 CTD PMID:17473847 PMID:31629013 PMID:33007385 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO
EXP		 [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; Captopril inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]
Captopril inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]
[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]		 CTD PMID:31181250 PMID:33007385 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Agt angiotensinogen multiple interactions EXP
ISO		 [icatibant co-treated with Captopril] inhibits the reaction [bisphenol A results in increased expression of AGT protein]; Captopril inhibits the reaction [bisphenol A results in increased expression of AGT protein]; Captopril inhibits the reaction [Pregabalin results in decreased expression of AGT protein]
Captopril inhibits the reaction [AGT protein results in decreased abundance of angiotensin I (1-7)]; Captopril inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]; Captopril inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]; Captopril inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]; Captopril inhibits the reaction [AGT protein results in decreased expression of MAS1 protein]; Captopril inhibits the reaction [AGT protein results in increased expression of ACE mRNA]; Captopril inhibits the reaction [AGT protein results in increased expression of ACE protein]; Captopril inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; Captopril inhibits the reaction [AGT protein results in increased expression of AGT protein]; Captopril inhibits the reaction [AGT protein results in increased expression of AGTR1 protein]; Captopril inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]; Captopril inhibits the reaction [AGT protein results in increased expression of VIM protein]; Captopril inhibits the reaction [LEPR protein affects the expression of AGT protein]; Captopril inhibits the reaction [Silicon Dioxide results in decreased expression of AGT protein alternative form]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of AGT protein]
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in decreased expression of GLI3 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in decreased expression of PTCH1 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of GLI1 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of GLI2 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of SHH protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of SMO protein]; Captopril inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; Captopril inhibits the reaction [Cadmium Chloride results in increased expression of AGT protein]		 CTD PMID:28130181 PMID:31181250 PMID:31629013 PMID:33007385 PMID:35844137 More... NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions EXP
ISO		 Captopril inhibits the reaction [Pregabalin results in increased expression of AGTR1 protein]
Captopril inhibits the reaction [AGT protein results in increased expression of AGTR1 protein]; Captopril inhibits the reaction [LEPR protein affects the expression of AGTR1A mRNA]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of AGTR1 protein]		 CTD PMID:28130181 PMID:31629013 PMID:33007385 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO Captopril inhibits the reaction [Glucose results in increased expression of AKT1 mRNA] CTD PMID:38115276 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions EXP Captopril inhibits the reaction [Methotrexate results in increased expression of and results in increased secretion of ALPL protein] CTD PMID:27269004 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446 		JBrowse link
G Bdkrb2 bradykinin receptor B2 multiple interactions ISO Captopril inhibits the reaction [LEPR protein affects the expression of BDKRB2 protein] CTD PMID:28130181 NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497 		JBrowse link
G Calb1 calbindin 1 multiple interactions ISO Captopril promotes the reaction [LEPR protein affects the expression of CALB1 protein] CTD PMID:28130181 NCBI chr 5:29,375,624...29,402,532
Ensembl chr 5:29,375,642...29,402,431 		JBrowse link
G Car2 carbonic anhydrase 2 multiple interactions ISO Captopril promotes the reaction [LEPR protein affects the expression of CAR2 mRNA] CTD PMID:28130181 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP
ISO		 Captopril inhibits the reaction [Methotrexate results in increased expression of CASP3 protein]
Captopril inhibits the reaction [Glucose results in increased expression of CASP3 mRNA]		 CTD PMID:27269004 PMID:38115276 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO Captopril inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]; Captopril inhibits the reaction [Silicon Dioxide results in decreased expression of CDH1 protein] CTD PMID:33007385 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions ISO Captopril inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of COL3A1 protein] CTD PMID:33007385 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547 		JBrowse link
G Gli1 GLI family zinc finger 1 multiple interactions EXP
ISO		 [goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of GLI1 protein]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of GLI1 protein]
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of GLI1 protein]		 CTD PMID:31181250 NCBI chr 7:63,156,926...63,169,579
Ensembl chr 7:63,156,926...63,169,251 		JBrowse link
G Gli2 GLI family zinc finger 2 multiple interactions EXP
ISO		 [goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of GLI2 protein]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of GLI2 protein]
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of GLI2 protein]		 CTD PMID:31181250 NCBI chr13:29,946,882...30,163,589
Ensembl chr13:29,946,809...30,163,574 		JBrowse link
G Gli3 GLI family zinc finger 3 multiple interactions ISO
EXP		 [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in decreased expression of GLI3 protein]
[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in decreased expression of GLI3 protein]; Captopril inhibits the reaction [Silicon Dioxide results in decreased expression of GLI3 protein]		 CTD PMID:31181250 NCBI chr17:49,438,567...49,709,712
Ensembl chr17:49,438,567...49,709,712 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 multiple interactions EXP Captopril inhibits the reaction [Methotrexate results in increased expression of and results in increased secretion of GOT1 protein] CTD PMID:27269004 NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP Captopril inhibits the reaction [Methotrexate results in increased expression of and results in increased secretion of GPT protein] CTD PMID:27269004 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP
ISO		 [icatibant co-treated with Captopril] inhibits the reaction [bisphenol A results in increased expression of IL6 protein]; Captopril inhibits the reaction [bisphenol A results in increased expression of IL6 protein]
Captopril inhibits the reaction [Glucose results in increased expression of IL6 mRNA]		 CTD PMID:38027817 PMID:38115276 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Kng1 kininogen 1 multiple interactions EXP [icatibant co-treated with Captopril] inhibits the reaction [bisphenol A results in increased expression of KNG1 protein]; Captopril inhibits the reaction [bisphenol A results in increased expression of KNG1 protein] CTD PMID:38027817 NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555 		JBrowse link
G Lepr leptin receptor multiple interactions
affects response to substance		 ISO Captopril inhibits the reaction [LEPR protein affects the expression of AGT protein]; Captopril inhibits the reaction [LEPR protein affects the expression of AGTR1A mRNA]; Captopril inhibits the reaction [LEPR protein affects the expression of BDKRB2 protein]; Captopril inhibits the reaction [LEPR protein affects the expression of PTH protein]; Captopril inhibits the reaction [LEPR protein affects the expression of VEGFA mRNA]; Captopril promotes the reaction [LEPR protein affects the expression of CALB1 protein]; Captopril promotes the reaction [LEPR protein affects the expression of CAR2 mRNA]; Captopril promotes the reaction [LEPR protein affects the expression of MMP9 mRNA]; Captopril promotes the reaction [LEPR protein affects the expression of RUNX2 mRNA]; Captopril promotes the reaction [LEPR protein affects the expression of VDR protein]
LEPR protein affects the susceptibility to Captopril		 CTD PMID:28130181 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908 		JBrowse link
G Mas1 MAS1 proto-oncogene, G protein-coupled receptor multiple interactions EXP
ISO		 Captopril inhibits the reaction [Pregabalin results in decreased expression of MAS1 protein]
Captopril inhibits the reaction [AGT protein results in decreased expression of MAS1 protein]; Captopril inhibits the reaction [Silicon Dioxide results in decreased expression of MAS1 protein]		 CTD PMID:31629013 PMID:33007385 NCBI chr 1:47,879,956...47,911,500
Ensembl chr 1:47,880,309...47,911,709 		JBrowse link
G Mir146a microRNA 146a multiple interactions EXP captopril inhibits the reaction [ischemia-reperfusion injury increases expression of Mir146a miRNA in kidney] RGD PMID:27760486 RGD:155882556 NCBI chr10:27,848,516...27,848,610
Ensembl chr10:27,848,516...27,848,610 		JBrowse link
G Mir320a microRNA 320a multiple interactions EXP captopril inhibits the reaction [ischemia-reperfusion injury increases expression of Mir320a miRNA in kidney] RGD PMID:27760486 RGD:155882556 NCBI chr15:45,516,392...45,516,473
Ensembl chr15:45,516,392...45,516,473 		JBrowse link
G Mlkl mixed lineage kinase domain like pseudokinase multiple interactions ISO Captopril inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MLKL protein] CTD PMID:35844137 NCBI chr19:39,277,526...39,304,555
Ensembl chr19:39,276,785...39,304,502 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Captopril promotes the reaction [LEPR protein affects the expression of MMP9 mRNA] CTD PMID:28130181 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP Captopril inhibits the reaction [Methotrexate results in increased expression of NOS2 protein] CTD PMID:27269004 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nppb natriuretic peptide B multiple interactions EXP Captopril inhibits the reaction [Pregabalin results in increased expression of NPPB protein] CTD PMID:31629013 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168 		JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha multiple interactions EXP Captopril inhibits the reaction [Pregabalin results in decreased expression of PRKACA protein] CTD PMID:31629013 NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430 		JBrowse link
G Ptch1 patched 1 multiple interactions EXP
ISO		 [goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in decreased expression of PTCH1 protein]; Captopril inhibits the reaction [Silicon Dioxide results in decreased expression of PTCH1 protein]
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in decreased expression of PTCH1 protein]		 CTD PMID:31181250 NCBI chr17:1,542,705...1,607,730
Ensembl chr17:1,542,877...1,607,333 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP
ISO		 Captopril inhibits the reaction [Methotrexate results in increased expression of PTGS2 protein]
Captopril inhibits the reaction [Glucose results in increased expression of PTGS2 mRNA]		 CTD PMID:27269004 PMID:38115276 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Pth parathyroid hormone multiple interactions ISO Captopril inhibits the reaction [LEPR protein affects the expression of PTH protein] CTD PMID:28130181 NCBI chr 1:167,508,121...167,511,530
Ensembl chr 1:167,508,598...167,511,530 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Captopril inhibits the reaction [Glucose results in increased phosphorylation of and results in increased localization of RELA protein] CTD PMID:38115276 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 multiple interactions ISO Captopril inhibits the reaction [Cadmium Chloride results in increased expression of RIPK3 protein] CTD PMID:35844137 NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121 		JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions ISO Captopril promotes the reaction [LEPR protein affects the expression of RUNX2 mRNA] CTD PMID:28130181 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167 		JBrowse link
G Shh sonic hedgehog signaling molecule multiple interactions ISO
EXP		 [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of SHH protein]
[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of SHH protein]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of SHH protein]		 CTD PMID:31181250 NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170 		JBrowse link
G Smo smoothened, frizzled class receptor multiple interactions ISO
EXP		 [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of SMO protein]
[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of SMO protein]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of SMO protein]		 CTD PMID:31181250 NCBI chr 4:58,343,626...58,373,823
Ensembl chr 4:58,343,529...58,373,829 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP Captopril inhibits the reaction [Methotrexate results in decreased expression of and results in decreased activity of SOD1 protein] CTD PMID:27269004 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP [icatibant co-treated with Captopril] inhibits the reaction [bisphenol A results in increased expression of TGFB1 protein]; Captopril inhibits the reaction [bisphenol A results in increased expression of TGFB1 protein] CTD PMID:38027817 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO		 [icatibant co-treated with Captopril] inhibits the reaction [bisphenol A results in increased expression of TNF protein]; Captopril inhibits the reaction [bisphenol A results in increased expression of TNF protein]
Captopril inhibits the reaction [Glucose results in increased expression of TNF mRNA]		 CTD PMID:38027817 PMID:38115276 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO Captopril inhibits the reaction [Glucose results in increased expression of VCAM1 mRNA] CTD PMID:38115276 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
G Vdr vitamin D receptor multiple interactions ISO Captopril promotes the reaction [LEPR protein affects the expression of VDR protein] CTD PMID:28130181 NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Captopril inhibits the reaction [LEPR protein affects the expression of VEGFA mRNA] CTD PMID:28130181 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Vim vimentin multiple interactions ISO Captopril inhibits the reaction [AGT protein results in increased expression of VIM protein]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of VIM protein] CTD PMID:33007385 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
clindamycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
increases expression		 ISO Clindamycin results in increased expression of and results in increased activity of CYP3A4 protein
Clindamycin results in increased expression of CYP3A4 mRNA		 CTD PMID:18505790 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Mmp13 matrix metallopeptidase 13 increases expression ISO Clindamycin results in increased expression of MMP13 mRNA CTD PMID:20338993 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239 		JBrowse link
G RT1-A2 RT1 class Ia, locus A2 affects expression ISO Clindamycin affects the expression of HLA-E mRNA CTD PMID:25811541 NCBI chr20:4,870,939...4,910,183 JBrowse link
G RT1-Db1 RT1 class II, locus Db1 affects expression ISO Clindamycin affects the expression of HLA-DRB1 mRNA CTD PMID:25811541 NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258 		JBrowse link
clindamycin phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pon1 paraoxonase 1 decreases activity ISO clindamycin phosphate results in decreased activity of PON1 protein CTD PMID:16880604 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360 		JBrowse link
domoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression
increases localization
multiple interactions		 ISO domoic acid results in increased expression of BAX mRNA
domoic acid results in increased localization of BAX protein
Carbachol inhibits the reaction [domoic acid results in increased localization of BAX protein]		 CTD PMID:18293405 PMID:19200344 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator affects expression ISO domoic acid affects the expression of BCL2 mRNA CTD PMID:18293405 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 ISO Carbachol inhibits the reaction [domoic acid results in increased activity of CASP3 protein] CTD PMID:19200344 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO domoic acid results in increased expression of GCLC mRNA; domoic acid results in increased expression of GCLC protein CTD PMID:23315585 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression
decreases response to substance
affects response to substance		 ISO domoic acid results in increased expression of GCLM mRNA; domoic acid results in increased expression of GCLM protein
[GCLM protein results in decreased susceptibility to domoic acid] which results in decreased susceptibility to 2,3-dimethoxy-1,4-naphthoquinone; [GCLM protein results in decreased susceptibility to domoic acid] which results in decreased susceptibility to Hydrogen Peroxide; GCLM protein results in decreased susceptibility to domoic acid; GCLM results in decreased susceptibility to domoic acid
GCLM affects the susceptibility to domoic acid		 CTD PMID:17804861 PMID:19200344 PMID:23315585 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 increases phosphorylation EXP domoic acid results in increased phosphorylation of GRIA1 protein CTD PMID:19564213 NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283 		JBrowse link
G Pvalb parvalbumin increases expression ISO domoic acid results in increased expression of PVALB protein CTD PMID:26797589 NCBI chr 7:109,772,939...109,787,954
Ensembl chr 7:109,772,593...109,784,561 		JBrowse link
G Wdr35 WD repeat domain 35 increases expression
multiple interactions		 EXP domoic acid results in increased expression of WDR35 mRNA; domoic acid results in increased expression of WDR35 protein
2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline inhibits the reaction [domoic acid results in increased expression of WDR35 protein]; Edaravone inhibits the reaction [domoic acid results in increased expression of WDR35 protein]		 CTD PMID:23289926 NCBI chr 6:31,771,315...31,831,450
Ensembl chr 6:31,771,360...31,831,029 		JBrowse link
fosinopril term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 decreases response to substance ISO ABCC1 protein results in decreased susceptibility to Fosinopril CTD PMID:22095822 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases response to substance
multiple interactions
increases export		 ISO ABCC2 protein results in decreased susceptibility to Fosinopril
ABCC2 protein affects the reaction [Fosinopril affects the export of Methotrexate]
desloratadine inhibits the reaction [ABCC2 protein results in increased export of Fosinopril]; Loratadine inhibits the reaction [ABCC2 protein results in increased export of Fosinopril]; Methotrexate inhibits the reaction [ABCC2 protein results in increased export of Fosinopril]		 CTD PMID:22095822 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Adipor2 adiponectin receptor 2 increases expression EXP fosinopril increases expression of adipor2 mRNA in rat liver RGD PMID:19076162 RGD:2307264 NCBI chr 4:152,524,604...152,588,848
Ensembl chr 4:152,524,623...152,559,355 		JBrowse link
G Afp alpha-fetoprotein multiple interactions ISO Fosinopril inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein] CTD PMID:29859236 NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480 		JBrowse link
G Agt angiotensinogen decreases expression EXP Fosinopril results in decreased expression of AGT protein CTD PMID:12411096 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Bmpr2 bone morphogenetic protein receptor type 2 multiple interactions EXP Fosinopril inhibits the reaction [Puromycin Aminonucleoside results in increased expression of BMPR2 mRNA] CTD PMID:17803470 NCBI chr 9:61,192,718...61,307,280
Ensembl chr 9:61,190,566...61,301,809 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO Fosinopril inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 mRNA] CTD PMID:29859236 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO Fosinopril inhibits the reaction [Diethylnitrosamine results in increased activity of GPT protein] CTD PMID:29859236 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Kl Klotho increases expression EXP Fosinopril results in increased expression of KL mRNA; Fosinopril results in increased expression of KL protein CTD PMID:21051829 NCBI chr12:490,402...531,417
Ensembl chr12:490,399...530,080 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO Fosinopril inhibits the reaction [Diethylnitrosamine results in increased expression of MMP2 protein] CTD PMID:29859236 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
multiple interactions		 EXP Fosinopril results in decreased expression of MMP9 mRNA; Fosinopril results in decreased expression of MMP9 protein
[Valsartan co-treated with Fosinopril] results in decreased expression of MMP9 mRNA; [Valsartan co-treated with Fosinopril] results in decreased expression of MMP9 protein		 CTD PMID:21051829 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Fosinopril inhibits the reaction [Diethylnitrosamine results in decreased expression of NFKB1 protein] CTD PMID:29859236 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nos3 nitric oxide synthase 3 affects expression EXP Fosinopril affects the expression of NOS3 mRNA; Fosinopril affects the expression of NOS3 protein CTD PMID:18209565 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Pde1a phosphodiesterase 1A affects expression EXP Fosinopril affects the expression of PDE1A mRNA; Fosinopril affects the expression of PDE1A protein CTD PMID:18209565 NCBI chr 3:64,745,140...65,025,178
Ensembl chr 3:64,747,269...65,024,874 		JBrowse link
G Pde1c phosphodiesterase 1C affects expression EXP Fosinopril affects the expression of PDE1C mRNA; Fosinopril affects the expression of PDE1C protein CTD PMID:18209565 NCBI chr 4:85,300,858...85,777,948
Ensembl chr 4:85,300,858...85,863,219 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Fosinopril inhibits the reaction [Diethylnitrosamine results in increased phosphorylation of RELA protein] CTD PMID:29859236 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Serpine1 serpin family E member 1 decreases expression
multiple interactions		 EXP Fosinopril results in decreased expression of SERPINE1 mRNA; Fosinopril results in decreased expression of SERPINE1 protein
[Valsartan co-treated with Fosinopril] results in decreased expression of SERPINE1 mRNA; [Valsartan co-treated with Fosinopril] results in decreased expression of SERPINE1 protein		 CTD PMID:21051829 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Slc15a1 solute carrier family 15 member 1 multiple interactions ISO Fosinopril inhibits the reaction [SLC15A1 protein results in increased uptake of glycylsarcosine] CTD PMID:18713951 NCBI chr15:98,537,641...98,582,544
Ensembl chr15:98,537,641...98,582,545 		JBrowse link
G Slc15a2 solute carrier family 15 member 2 multiple interactions EXP Fosinopril inhibits the reaction [SLC15A2 protein results in increased uptake of glycylsarcosine] CTD PMID:18713951 NCBI chr11:64,014,182...64,043,228
Ensembl chr11:64,014,182...64,043,225 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO Fosinopril inhibits the reaction [Diethylnitrosamine results in increased expression of TGFB1 protein] CTD PMID:29859236 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 decreases expression
multiple interactions		 EXP Fosinopril results in decreased expression of TIMP1 mRNA; Fosinopril results in decreased expression of TIMP1 protein
[Valsartan co-treated with Fosinopril] results in decreased expression of TIMP1 mRNA; [Valsartan co-treated with Fosinopril] results in decreased expression of TIMP1 protein		 CTD PMID:21051829 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Fosinopril inhibits the reaction [Diethylnitrosamine results in increased expression of TNF protein] CTD PMID:29859236 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Fosinopril inhibits the reaction [Diethylnitrosamine results in increased expression of VEGFA protein] CTD PMID:29859236 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
goralatide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme increases expression
decreases expression
multiple interactions		 ISO goralatide results in increased expression of ACE mRNA
goralatide results in decreased expression of ACE mRNA
[BDKRB1 protein affects the activity of ACE protein] which affects the hydrolysis of goralatide; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of ACE mRNA]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of ACE protein]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in decreased expression of ACE2 mRNA]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in decreased expression of CDH1 protein]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in increased expression of ACE mRNA]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in increased expression of ACE protein]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in increased expression of COL3A1 protein]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in increased expression of VIM protein]]; goralatide affects the reaction [ACE2 protein affects the reaction [Silicon Dioxide results in increased expression of ACE mRNA]]; goralatide inhibits the reaction [AGT protein results in increased expression of ACE mRNA]; goralatide inhibits the reaction [AGT protein results in increased expression of ACE protein]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of ACE mRNA]		 CTD PMID:20096676 PMID:33007385 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131 		JBrowse link
G Ace2 angiotensin converting enzyme 2 multiple interactions ISO ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in decreased expression of MAS1 protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of ACE mRNA]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of ACE protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of AGT protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in decreased expression of ACE2 mRNA]]; goralatide affects the reaction [ACE2 protein affects the reaction [AGT protein results in decreased abundance of angiotensin I (1-7)]]; goralatide affects the reaction [ACE2 protein affects the reaction [Silicon Dioxide results in decreased expression of ACE2 mRNA]]; goralatide affects the reaction [ACE2 protein affects the reaction [Silicon Dioxide results in decreased expression of ACE2 protein]]; goralatide affects the reaction [ACE2 protein affects the reaction [Silicon Dioxide results in increased expression of ACE mRNA]]; goralatide affects the reaction [ACE2 protein affects the reaction [Silicon Dioxide results in increased expression of AGT protein]]; goralatide inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]; goralatide inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]; goralatide inhibits the reaction [Silicon Dioxide results in decreased expression of ACE2 mRNA]; goralatide inhibits the reaction [Silicon Dioxide results in decreased expression of ACE2 protein] CTD PMID:33007385 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO
EXP		 [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; goralatide inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]
[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]
goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]]; goralatide inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]		 CTD PMID:31181250 PMID:33007385 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Agt angiotensinogen multiple interactions ISO ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in decreased expression of MAS1 protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of ACE mRNA]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of ACE protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of AGT protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]]; goralatide affects the reaction [ACE2 protein affects the reaction [AGT protein results in decreased abundance of angiotensin I (1-7)]]; goralatide affects the reaction [ACE2 protein affects the reaction [Silicon Dioxide results in increased expression of AGT protein]]; goralatide inhibits the reaction [AGT protein results in decreased abundance of angiotensin I (1-7)]; goralatide inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]; goralatide inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]; goralatide inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]; goralatide inhibits the reaction [AGT protein results in decreased expression of MAS1 protein]; goralatide inhibits the reaction [AGT protein results in increased expression of ACE mRNA]; goralatide inhibits the reaction [AGT protein results in increased expression of ACE protein]; goralatide inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; goralatide inhibits the reaction [AGT protein results in increased expression of AGT protein]; goralatide inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]; goralatide inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]; goralatide inhibits the reaction [AGT protein results in increased expression of VIM protein]; goralatide inhibits the reaction [Silicon Dioxide results in decreased expression of AGT protein alternative form]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of AGT protein]
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in decreased expression of GLI3 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in decreased expression of PTCH1 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of GLI1 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of GLI2 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of SHH protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of SMO protein]; goralatide inhibits the reaction [AGT protein results in decreased expression of GLI3 protein]; goralatide inhibits the reaction [AGT protein results in decreased expression of PTCH1 protein]; goralatide inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; goralatide inhibits the reaction [AGT protein results in increased expression of GLI1 protein]; goralatide inhibits the reaction [AGT protein results in increased expression of GLI2 protein]; goralatide inhibits the reaction [AGT protein results in increased expression of SHH protein]; goralatide inhibits the reaction [AGT protein results in increased expression of SMO protein]		 CTD PMID:31181250 PMID:33007385 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions ISO ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]]; goralatide inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of AGTR1 protein] CTD PMID:33007385 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Bdkrb1 bradykinin receptor B1 affects abundance
multiple interactions		 ISO BDKRB1 protein affects the abundance of goralatide
[BDKRB1 protein affects the activity of ACE protein] which affects the hydrolysis of goralatide		 CTD PMID:20096676 NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747 		JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in decreased expression of CDH1 protein]]; goralatide inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]; goralatide inhibits the reaction [Silicon Dioxide results in decreased expression of CDH1 protein] CTD PMID:33007385 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions ISO ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in increased expression of COL3A1 protein]]; goralatide inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of COL3A1 protein] CTD PMID:33007385 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547 		JBrowse link
G Gli1 GLI family zinc finger 1 multiple interactions ISO
EXP		 [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of GLI1 protein]; goralatide inhibits the reaction [AGT protein results in increased expression of GLI1 protein]
[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of GLI1 protein]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of GLI1 protein]		 CTD PMID:31181250 NCBI chr 7:63,156,926...63,169,579
Ensembl chr 7:63,156,926...63,169,251 		JBrowse link
G Gli2 GLI family zinc finger 2 multiple interactions ISO
EXP		 [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of GLI2 protein]; goralatide inhibits the reaction [AGT protein results in increased expression of GLI2 protein]
[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of GLI2 protein]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of GLI2 protein]		 CTD PMID:31181250 NCBI chr13:29,946,882...30,163,589
Ensembl chr13:29,946,809...30,163,574 		JBrowse link
G Gli3 GLI family zinc finger 3 multiple interactions EXP
ISO		 [goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in decreased expression of GLI3 protein]; goralatide inhibits the reaction [Silicon Dioxide results in decreased expression of GLI3 protein]
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in decreased expression of GLI3 protein]; goralatide inhibits the reaction [AGT protein results in decreased expression of GLI3 protein]		 CTD PMID:31181250 NCBI chr17:49,438,567...49,709,712
Ensembl chr17:49,438,567...49,709,712 		JBrowse link
G Mas1 MAS1 proto-oncogene, G protein-coupled receptor multiple interactions ISO ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in decreased expression of MAS1 protein]]; goralatide inhibits the reaction [AGT protein results in decreased expression of MAS1 protein]; goralatide inhibits the reaction [Silicon Dioxide results in decreased expression of MAS1 protein] CTD PMID:33007385 NCBI chr 1:47,879,956...47,911,500
Ensembl chr 1:47,880,309...47,911,709 		JBrowse link
G Ptch1 patched 1 multiple interactions EXP
ISO		 [goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in decreased expression of PTCH1 protein]; goralatide inhibits the reaction [Silicon Dioxide results in decreased expression of PTCH1 protein]
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in decreased expression of PTCH1 protein]; goralatide inhibits the reaction [AGT protein results in decreased expression of PTCH1 protein]		 CTD PMID:31181250 NCBI chr17:1,542,705...1,607,730
Ensembl chr17:1,542,877...1,607,333 		JBrowse link
G Shh sonic hedgehog signaling molecule multiple interactions ISO
EXP		 [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of SHH protein]; goralatide inhibits the reaction [AGT protein results in increased expression of SHH protein]
[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of SHH protein]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of SHH protein]		 CTD PMID:31181250 NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170 		JBrowse link
G Smo smoothened, frizzled class receptor multiple interactions EXP
ISO		 [goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of SMO protein]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of SMO protein]
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of SMO protein]; goralatide inhibits the reaction [AGT protein results in increased expression of SMO protein]		 CTD PMID:31181250 NCBI chr 4:58,343,626...58,373,823
Ensembl chr 4:58,343,529...58,373,829 		JBrowse link
G Vim vimentin multiple interactions ISO goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in increased expression of VIM protein]]; goralatide inhibits the reaction [AGT protein results in increased expression of VIM protein]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of VIM protein] CTD PMID:33007385 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
kainic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression EXP Kainic Acid results in increased expression of ABCB1A mRNA; Kainic Acid results in increased expression of ABCB1A protein CTD PMID:14706787 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B increases expression EXP Kainic Acid results in increased expression of ABCB1B mRNA; Kainic Acid results in increased expression of ABCB1B protein CTD PMID:14706787 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 increases expression ISO Kainic Acid results in increased expression of ABCG2 mRNA CTD PMID:17997037 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Aco2 aconitase 2 multiple interactions
decreases activity		 EXP 6-Cyano-7-nitroquinoxaline-2,3-dione inhibits the reaction [Kainic Acid results in decreased activity of ACO2 protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Kainic Acid results in decreased activity of ACO2 protein] CTD PMID:11520895 NCBI chr 7:113,385,677...113,428,794
Ensembl chr 7:113,385,646...113,428,261 		JBrowse link
G Acp1 acid phosphatase 1 decreases expression ISO Kainic Acid results in decreased expression of ACP1 mRNA CTD PMID:17997037 NCBI chr 6:47,506,380...47,522,021
Ensembl chr 6:47,506,380...47,522,021 		JBrowse link
G Adk adenosine kinase increases expression ISO Kainic Acid results in increased expression of ADK mRNA CTD PMID:17997037 NCBI chr15:2,863,241...3,246,453
Ensembl chr15:2,863,244...3,246,510 		JBrowse link
G Adnp activity-dependent neuroprotector homeobox multiple interactions
decreases expression		 EXP Enzyme Inhibitors inhibits the reaction [Kainic Acid results in decreased expression of ADNP protein]
Kainic Acid results in decreased expression of ADNP mRNA; Kainic Acid results in decreased expression of ADNP protein		 CTD PMID:18375135 NCBI chr 3:156,886,921...156,921,500
Ensembl chr 3:156,891,381...156,917,312 		JBrowse link
G Adra1b adrenoceptor alpha 1B increases response to substance ISO ADRA1B protein results in increased susceptibility to Kainic Acid CTD PMID:19125850 NCBI chr10:28,255,025...28,373,418
Ensembl chr10:28,255,025...28,312,919 		JBrowse link
G Aif1 allograft inflammatory factor 1 increases expression
multiple interactions		 EXP
ISO		 Kainic Acid results in increased expression of AIF1 protein
[cyanoginosin LR co-treated with Kainic Acid] results in increased expression of AIF1 protein
NADP inhibits the reaction [Kainic Acid results in increased expression of AIF1 protein]		 CTD PMID:32057834 PMID:34352349 NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668 		JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 increases localization
multiple interactions		 ISO Kainic Acid results in increased localization of AIFM1 protein
Minocycline inhibits the reaction [Kainic Acid results in increased localization of AIFM1 protein]		 CTD PMID:16469440 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256 		JBrowse link
G Alox5ap arachidonate 5-lipoxygenase activating protein increases expression EXP Kainic Acid results in increased expression of ALOX5AP mRNA CTD PMID:19700661 NCBI chr12:5,748,941...5,772,986
Ensembl chr12:5,748,944...5,772,986 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 increases expression ISO Kainic Acid results in increased expression of APAF1 mRNA CTD PMID:17997037 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540 		JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 multiple interactions EXP [Raloxifene Hydrochloride co-treated with Kainic Acid] results in increased expression of APEX1 mRNA CTD PMID:16120186 NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785 		JBrowse link
G Apoe apolipoprotein E decreases expression ISO Kainic Acid results in decreased expression of APOE mRNA CTD PMID:17997037 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G Arc activity-regulated cytoskeleton-associated protein increases expression EXP
ISO		 Kainic Acid results in increased expression of ARC mRNA; Kainic Acid results in increased expression of ARC protein CTD PMID:17632064 PMID:30557575 NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378 		JBrowse link
G Atf7ip activating transcription factor 7 interacting protein decreases expression EXP Kainic Acid results in decreased expression of ATF7IP mRNA CTD PMID:19700661 NCBI chr 4:169,385,872...169,471,652
Ensembl chr 4:169,385,872...169,471,650 		JBrowse link
G Atg5 autophagy related 5 multiple interactions
increases expression		 EXP NADP inhibits the reaction [Kainic Acid results in increased expression of ATG5 protein] CTD PMID:32057834 NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209 		JBrowse link
G B4galt2 beta-1,4-galactosyltransferase 2 decreases expression ISO Kainic Acid results in decreased expression of B4GALT2 mRNA CTD PMID:17997037 NCBI chr 5:131,412,541...131,422,573
Ensembl chr 5:131,412,541...131,421,013 		JBrowse link
G Bag3 BAG cochaperone 3 increases expression EXP Kainic Acid results in increased expression of BAG3 mRNA CTD PMID:19700661 NCBI chr 1:183,103,038...183,126,862
Ensembl chr 1:183,102,871...183,126,858 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions		 EXP
ISO		 Kainic Acid results in increased expression of BAX mRNA; Kainic Acid results in increased expression of BAX protein
oridonin inhibits the reaction [Kainic Acid results in increased expression of BAX mRNA]
EPO protein inhibits the reaction [Kainic Acid results in increased expression of BAX protein]; EPOR protein promotes the reaction [EPO protein inhibits the reaction [Kainic Acid results in increased expression of BAX protein]]
Valproic Acid inhibits the reaction [Kainic Acid results in increased expression of BAX protein]		 CTD PMID:18711747 PMID:19700661 PMID:25453207 PMID:31430510 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression		 ISO
EXP		 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione inhibits the reaction [Kainic Acid results in decreased expression of BCL2 protein]; 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione promotes the reaction [Valproic Acid inhibits the reaction [Kainic Acid results in decreased expression of BCL2 protein]]; Valproic Acid inhibits the reaction [Kainic Acid results in decreased expression of BCL2 protein]
Kainic Acid results in decreased expression of BCL2 mRNA
oridonin inhibits the reaction [Kainic Acid results in decreased expression of BCL2 mRNA]		 CTD PMID:25453207 PMID:31430510 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions
increases expression		 EXP [Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of BDNF mRNA]; [diacetylcurcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of BDNF mRNA]
Kainic Acid results in increased expression of BDNF mRNA; Kainic Acid results in increased expression of BDNF protein		 CTD PMID:1641125 PMID:9073163 PMID:11279263 PMID:16166269 PMID:17827730 More... NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Becn1 beclin 1 multiple interactions
increases expression		 EXP NADP inhibits the reaction [Kainic Acid results in increased expression of BECN1 protein] CTD PMID:32057834 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G C1qb complement C1q B chain increases expression
multiple interactions		 ISO
EXP		 Kainic Acid results in increased expression of C1QB mRNA
Phenobarbital inhibits the reaction [Kainic Acid results in increased expression of C1QB mRNA]
Kainic Acid results in increased expression of C1QB mRNA; Kainic Acid results in increased expression of C1QB protein		 CTD PMID:7870303 PMID:17997037 NCBI chr 5:149,118,843...149,124,394
Ensembl chr 5:149,118,846...149,124,407 		JBrowse link
G C4b complement C4B increases expression ISO Kainic Acid results in increased expression of C4B mRNA CTD PMID:17997037 NCBI chr20:4,197,371...4,211,684
Ensembl chr20:4,197,366...4,211,681 		JBrowse link
G Calb1 calbindin 1 decreases expression ISO Kainic Acid results in decreased expression of CALB1 mRNA CTD PMID:17997037 NCBI chr 5:29,375,624...29,402,532
Ensembl chr 5:29,375,642...29,402,431 		JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha multiple interactions
increases phosphorylation		 ISO cyanoginosin LR inhibits the reaction [Kainic Acid results in increased phosphorylation of CAMK2A protein] CTD PMID:34352349 NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994 		JBrowse link
G Camk4 calcium/calmodulin-dependent protein kinase IV decreases expression ISO Kainic Acid results in decreased expression of CAMK4 mRNA CTD PMID:17997037 NCBI chr18:24,582,988...24,811,918
Ensembl chr18:24,585,269...24,802,487 		JBrowse link
G Capns1 calpain, small subunit 1 increases expression EXP Kainic Acid results in increased expression of CAPNS1 mRNA CTD PMID:19700661 NCBI chr 1:85,444,613...85,454,861
Ensembl chr 1:85,444,608...85,454,795 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
increases cleavage
increases expression		 ISO
EXP		 Kainic Acid results in increased activity of CASP3 protein
oridonin inhibits the reaction [Kainic Acid results in increased activity of CASP3 protein]
EPO protein inhibits the reaction [Kainic Acid results in increased expression of CASP3 protein]
Kainic Acid results in increased cleavage of CASP3 protein
Kainic Acid results in increased expression of CASP3 mRNA; Kainic Acid results in increased expression of CASP3 protein
4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione inhibits the reaction [Kainic Acid results in increased cleavage of CASP3 protein]; 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione promotes the reaction [Valproic Acid inhibits the reaction [Kainic Acid results in increased cleavage of CASP3 protein]]; Minocycline inhibits the reaction [Kainic Acid results in increased activity of CASP3 protein]; Valproic Acid inhibits the reaction [Kainic Acid results in increased cleavage of CASP3 protein]		 CTD PMID:16469440 PMID:18711747 PMID:19700661 PMID:25453207 PMID:31430510 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase decreases expression
decreases activity
multiple interactions		 ISO
EXP		 Kainic Acid results in decreased expression of CAT mRNA; Kainic Acid results in decreased expression of CAT protein
Kainic Acid results in decreased activity of CAT protein
oridonin inhibits the reaction [Kainic Acid results in decreased activity of CAT protein]		 CTD PMID:29208536 PMID:31430510 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cck cholecystokinin decreases expression EXP Kainic Acid results in decreased expression of CCK protein CTD PMID:7774662 NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression EXP Kainic Acid results in increased expression of CCL2 mRNA CTD PMID:19700661 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccne1 cyclin E1 increases expression EXP Kainic Acid results in increased expression of CCNE1 protein CTD PMID:12941380 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Cd68 Cd68 molecule increases expression EXP Kainic Acid results in increased expression of CD68 mRNA CTD PMID:19700661 NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697 		JBrowse link
G Cdc42 cell division cycle 42 increases expression EXP Kainic Acid results in increased expression of CDC42 mRNA CTD PMID:19700661 NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111 		JBrowse link
G Cdh13 cadherin 13 increases expression ISO Kainic Acid results in increased expression of CDH13 mRNA CTD PMID:17997037 NCBI chr19:46,349,562...47,387,462
Ensembl chr19:46,349,430...47,387,459 		JBrowse link
G Cdk2 cyclin dependent kinase 2 increases expression EXP Kainic Acid results in increased expression of CDK2 protein CTD PMID:12941380 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 increases expression ISO Kainic Acid results in increased expression of CEACAM1 mRNA CTD PMID:17997037 NCBI chr 1:81,043,595...81,060,050
Ensembl chr 1:81,043,595...81,059,992 		JBrowse link
G Chgb chromogranin B increases expression EXP Kainic Acid results in increased expression of CHGB mRNA CTD PMID:9427505 NCBI chr 3:120,043,824...120,057,169
Ensembl chr 3:120,043,738...120,057,166 		JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 increases expression EXP Kainic Acid results in increased expression of CITED2 mRNA CTD PMID:19700661 NCBI chr 1:12,312,426...12,314,869
Ensembl chr 1:12,312,160...12,314,897 		JBrowse link
G Clu clusterin increases expression
multiple interactions		 EXP Kainic Acid results in increased expression of CLU mRNA; Kainic Acid results in increased expression of CLU protein
Phenobarbital inhibits the reaction [Kainic Acid results in increased expression of CLU mRNA]		 CTD PMID:7870303 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315 		JBrowse link
G Cnr1 cannabinoid receptor 1 increases expression EXP Kainic Acid results in increased expression of CNR1 mRNA CTD PMID:22079489 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099 		JBrowse link
G Cnrip1 cannabinoid receptor interacting protein 1 increases expression EXP Kainic Acid results in increased expression of CNRIP1 mRNA CTD PMID:22079489 NCBI chr14:91,462,877...91,492,739
Ensembl chr14:91,462,647...91,492,735 		JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression ISO Kainic Acid results in increased expression of COL1A1 mRNA CTD PMID:17997037 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 increases expression EXP Kainic Acid results in increased expression of CRHR1 mRNA CTD PMID:12093084 NCBI chr10:89,040,186...89,083,481
Ensembl chr10:89,040,203...89,083,481 		JBrowse link
G Ctsb cathepsin B multiple interactions
increases expression		 EXP NADP inhibits the reaction [Kainic Acid results in increased expression of CTSB protein] CTD PMID:32057834 NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500 		JBrowse link
G Ctsd cathepsin D multiple interactions
increases expression		 EXP NADP inhibits the reaction [Kainic Acid results in increased expression of CTSD protein] CTD PMID:32057834 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488 		JBrowse link
G Ctss cathepsin S increases expression ISO Kainic Acid results in increased expression of CTSS mRNA; Kainic Acid results in increased expression of CTSS protein CTD PMID:17997037 NCBI chr 2:183,086,437...183,114,483
Ensembl chr 2:183,086,437...183,114,483 		JBrowse link
G Ctsz cathepsin Z increases expression ISO Kainic Acid results in increased expression of CTSZ mRNA CTD PMID:17997037 NCBI chr 3:163,224,875...163,235,645
Ensembl chr 3:163,224,875...163,235,645 		JBrowse link
G Cycs cytochrome c, somatic increases localization
multiple interactions
increases expression		 ISO
EXP		 Kainic Acid results in increased localization of CYCS protein
Minocycline inhibits the reaction [Kainic Acid results in increased localization of CYCS protein]
Kainic Acid results in increased expression of CYCS mRNA		 CTD PMID:16469440 PMID:19700661 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Dgcr6 DiGeorge syndrome critical region gene 6 decreases expression ISO Kainic Acid results in decreased expression of DGCR6 mRNA CTD PMID:17997037 NCBI chr11:82,927,725...82,932,823
Ensembl chr11:82,927,725...82,932,823 		JBrowse link
G Dhx36 DEAH-box helicase 36 increases expression ISO Kainic Acid results in increased expression of DHX36 mRNA CTD PMID:17997037 NCBI chr 2:146,856,469...146,894,577
Ensembl chr 2:146,856,469...146,894,572 		JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein increases expression EXP Kainic Acid results in increased expression of DIABLO mRNA CTD PMID:19700661 NCBI chr12:33,055,784...33,070,401
Ensembl chr12:33,055,263...33,070,387 		JBrowse link
G Drd2 dopamine receptor D2 decreases response to substance ISO DRD2 protein results in decreased susceptibility to Kainic Acid CTD PMID:11860278 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Egr1 early growth response 1 decreases expression
affects expression		 ISO
EXP		 Kainic Acid results in decreased expression of EGR1 mRNA
Kainic Acid affects the expression of EGR1 mRNA		 CTD PMID:17997037 PMID:19700661 NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions ISO [cyanoginosin LR co-treated with Kainic Acid] results in increased phosphorylation of EIF2AK3 protein CTD PMID:34352349 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation EXP kainic acid increases phosphorylation of Eif2s1 in rat neurons RGD PMID:17251432 RGD:10755427 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225 		JBrowse link
G Eif4a3 eukaryotic translation initiation factor 4A3 increases expression EXP Kainic Acid results in increased expression of EIF4A3 protein CTD PMID:17632064 NCBI chr10:104,549,038...104,559,032
Ensembl chr10:104,549,038...104,559,057 		JBrowse link
G Emc3 ER membrane protein complex subunit 3 decreases expression ISO Kainic Acid results in decreased expression of EMC3 mRNA CTD PMID:17997037 NCBI chr 4:146,663,065...146,678,976
Ensembl chr 4:146,663,067...146,679,029 		JBrowse link
G En2 engrailed homeobox 2 affects response to substance
decreases expression		 ISO EN2 protein affects the susceptibility to Kainic Acid
Kainic Acid results in decreased expression of EN2 mRNA		 CTD PMID:19186208 NCBI chr 4:7,221,096...7,226,943
Ensembl chr 4:7,221,096...7,226,943 		JBrowse link
G Enc1 ectodermal-neural cortex 1 decreases expression ISO Kainic Acid results in decreased expression of ENC1 mRNA CTD PMID:17997037 NCBI chr 2:28,550,670...28,562,591
Ensembl chr 2:28,550,464...28,562,713 		JBrowse link
G Epo erythropoietin multiple interactions ISO EPO protein inhibits the reaction [Kainic Acid results in decreased expression of EPOR protein]; EPO protein inhibits the reaction [Kainic Acid results in decreased expression of JAK2 protein]; EPO protein inhibits the reaction [Kainic Acid results in increased expression of BAX protein]; EPO protein inhibits the reaction [Kainic Acid results in increased expression of CASP3 protein]; EPO protein inhibits the reaction [Kainic Acid results in increased expression of GFAP protein]; EPOR protein promotes the reaction [EPO protein inhibits the reaction [Kainic Acid results in decreased expression of EPOR protein]]; EPOR protein promotes the reaction [EPO protein inhibits the reaction [Kainic Acid results in decreased expression of JAK2 protein]]; EPOR protein promotes the reaction [EPO protein inhibits the reaction [Kainic Acid results in increased expression of BAX protein]] CTD PMID:18711747 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946 		JBrowse link
G Epor erythropoietin receptor multiple interactions
decreases expression		 ISO
EXP		 EPO protein inhibits the reaction [Kainic Acid results in decreased expression of EPOR protein]; EPOR protein promotes the reaction [EPO protein inhibits the reaction [Kainic Acid results in decreased expression of EPOR protein]]; EPOR protein promotes the reaction [EPO protein inhibits the reaction [Kainic Acid results in decreased expression of JAK2 protein]]; EPOR protein promotes the reaction [EPO protein inhibits the reaction [Kainic Acid results in increased expression of BAX protein]] CTD PMID:18711747 NCBI chr 8:20,489,678...20,494,257
Ensembl chr 8:20,489,678...20,494,257 		JBrowse link
G Etfb electron transfer flavoprotein subunit beta decreases expression ISO Kainic Acid results in decreased expression of ETFB mRNA CTD PMID:17997037 NCBI chr 1:93,851,908...93,866,072
Ensembl chr 1:93,851,858...93,866,068 		JBrowse link
G Fbxw5 F-box and WD repeat domain containing 5 decreases expression ISO Kainic Acid results in decreased expression of FBXW5 mRNA CTD PMID:17997037 NCBI chr 3:8,322,543...8,327,092
Ensembl chr 3:8,322,543...8,327,092 		JBrowse link
G Fgf2 fibroblast growth factor 2 increases expression EXP Kainic Acid results in increased expression of FGF2 mRNA CTD PMID:7649223 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221 		JBrowse link
G Fgf5 fibroblast growth factor 5 increases expression EXP Kainic Acid results in increased expression of FGF5 mRNA CTD PMID:7649223 NCBI chr14:11,323,827...11,346,164
Ensembl chr14:11,325,334...11,345,997 		JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 increases expression EXP Kainic Acid results in increased expression of FGFR1 mRNA CTD PMID:7649223 NCBI chr16:66,491,930...66,547,161
Ensembl chr16:66,494,042...66,547,350 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
decreases expression		 ISO
EXP		 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone inhibits the reaction [Valproic Acid inhibits the reaction [Kainic Acid results in increased expression of FOS protein]]; [Kainic Acid co-treated with dihydroxyethyldithiocarbamate] results in increased expression of FOS protein; Dizocilpine Maleate inhibits the reaction [[Kainic Acid co-treated with dihydroxyethyldithiocarbamate] results in increased expression of FOS protein]; Valproic Acid inhibits the reaction [Kainic Acid results in increased expression of FOS protein]
Kainic Acid results in increased expression of FOS mRNA; Kainic Acid results in increased expression of FOS protein
[Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of FOS protein]; [diacetylcurcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of FOS protein]; [Phenytoin co-treated with Drugs, Chinese Herbal] inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]; Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]; Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS protein]; Diazepam inhibits the reaction [Kainic Acid results in increased expression of FOS protein]; dimemorfan inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]; dimemorfan inhibits the reaction [Kainic Acid results in increased expression of FOS protein]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS protein]]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of FOS protein]]; Pentobarbital inhibits the reaction [Kainic Acid results in increased expression of FOS protein]; SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]]; SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS protein]]; SIGMAR1 protein affects the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]]; SIGMAR1 protein affects the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of FOS protein]]; Valproic Acid inhibits the reaction [Kainic Acid results in increased expression of FOS protein]
Kainic Acid results in decreased expression of FOS mRNA		 CTD PMID:7655348 PMID:7887109 PMID:8417141 PMID:8758711 PMID:15723099 More... NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Fosl2 FOS like 2, AP-1 transcription factor subunit increases expression EXP Kainic Acid results in increased expression of FOSL2 mRNA CTD PMID:19700661 NCBI chr 6:24,297,898...24,319,219
Ensembl chr 6:24,300,956...24,320,034 		JBrowse link
G Fxyd1 FXYD domain-containing ion transport regulator 1 decreases expression ISO Kainic Acid results in decreased expression of FXYD1 mRNA CTD PMID:17997037 NCBI chr 1:86,287,163...86,291,478
Ensembl chr 1:86,287,165...86,291,278 		JBrowse link
G Gabrb1 gamma-aminobutyric acid type A receptor subunit beta1 increases expression
multiple interactions		 ISO Kainic Acid results in increased expression of GABRB1 mRNA
Quercetin inhibits the reaction [Kainic Acid results in increased expression of GABRB1 mRNA]		 CTD PMID:27386150 NCBI chr14:36,068,725...36,548,946
Ensembl chr14:36,080,393...36,548,948 		JBrowse link
G Gabrb3 gamma-aminobutyric acid type A receptor subunit beta 3 multiple interactions
increases expression		 ISO Quercetin inhibits the reaction [Kainic Acid results in increased expression of GABRB3 mRNA] CTD PMID:27386150 NCBI chr 1:108,467,047...108,702,522
Ensembl chr 1:108,296,124...108,698,961 		JBrowse link
G Gad1 glutamate decarboxylase 1 increases expression EXP Kainic Acid results in increased expression of GAD1 mRNA CTD PMID:16797850 NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333 		JBrowse link
G Gad2 glutamate decarboxylase 2 increases expression EXP Kainic Acid results in increased expression of GAD2 mRNA CTD PMID:16797850 NCBI chr17:84,763,630...84,826,155
Ensembl chr17:84,763,628...84,826,155 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression EXP Kainic Acid results in increased expression of GADD45A mRNA; Kainic Acid results in increased expression of GADD45A protein CTD PMID:20955365 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115 		JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta decreases expression ISO Kainic Acid results in decreased expression of GADD45B mRNA CTD PMID:17997037 NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046 		JBrowse link
G Gadd45g growth arrest and DNA-damage-inducible, gamma decreases expression ISO Kainic Acid results in decreased expression of GADD45G mRNA CTD PMID:17997037 NCBI chr17:13,376,842...13,378,587
Ensembl chr17:13,376,839...13,378,610 		JBrowse link
G Gap43 growth associated protein 43 multiple interactions
increases expression		 EXP Dizocilpine Maleate inhibits the reaction [Kainic Acid results in increased expression of GAP43 mRNA]; Pentobarbital inhibits the reaction [Kainic Acid results in increased expression of GAP43 mRNA] CTD PMID:8774942 NCBI chr11:58,376,371...58,470,047
Ensembl chr11:58,376,371...58,470,045 		JBrowse link
G Gcnt2 glucosaminyl (N-acetyl) transferase 2 increases expression ISO Kainic Acid results in increased expression of GCNT2 mRNA CTD PMID:17997037 NCBI chr17:23,796,859...23,901,625
Ensembl chr17:23,796,859...23,901,611 		JBrowse link
G Gfap glial fibrillary acidic protein increases expression
multiple interactions		 EXP
ISO		 Kainic Acid results in increased expression of GFAP mRNA; Kainic Acid results in increased expression of GFAP protein
NADP inhibits the reaction [Kainic Acid results in increased expression of GFAP protein]
EPO protein inhibits the reaction [Kainic Acid results in increased expression of GFAP protein]
PTGS2 affects the reaction [Kainic Acid results in increased expression of GFAP mRNA]		 CTD PMID:17997037 PMID:18711747 PMID:19700661 PMID:21589914 PMID:22790971 More... NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589 		JBrowse link
G Glul glutamate-ammonia ligase multiple interactions
decreases expression		 EXP oridonin inhibits the reaction [Kainic Acid results in decreased expression of GLUL mRNA] CTD PMID:31430510 NCBI chr13:65,969,053...66,035,121
Ensembl chr13:66,025,630...66,035,108 		JBrowse link
G Gpx1 glutathione peroxidase 1 decreases expression ISO Kainic Acid results in decreased expression of GPX1 protein CTD PMID:29208536 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 multiple interactions
increases phosphorylation
decreases expression		 EXP
ISO		 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Kainic Acid results in decreased expression of GRIA1 protein]; Kainic Acid binds to and results in increased activity of GRIA1 protein; Urethane inhibits the reaction [Kainic Acid binds to and results in increased activity of GRIA1 protein]
Kainic Acid results in increased phosphorylation of GRIA1 protein
Kainic Acid results in decreased expression of GRIA1 mRNA
Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIA1 mRNA]; Kainic Acid inhibits the reaction [cyanoginosin LR results in increased expression of and results in increased phosphorylation of GRIA1 protein]; PTGS2 affects the reaction [Kainic Acid results in decreased expression of GRIA1 mRNA]
Kainic Acid results in decreased expression of GRIA1 mRNA; Kainic Acid results in decreased expression of GRIA1 protein		 CTD PMID:7529610 PMID:11812690 PMID:17585341 PMID:21589914 PMID:34352349 NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283 		JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 multiple interactions
increases methylation
decreases expression
affects response to substance		 EXP
ISO		 Kainic Acid binds to and results in increased activity of GRIA2 protein; Urethane inhibits the reaction [Kainic Acid binds to and results in increased activity of GRIA2 protein]
Kainic Acid results in increased methylation of GRIA2 gene
Kainic Acid results in decreased expression of GRIA2 mRNA
Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIA2 mRNA]; RG108 inhibits the reaction [Kainic Acid results in increased methylation of GRIA2 gene]
GRIA2 protein affects the susceptibility to Kainic Acid		 CTD PMID:7529610 PMID:10551584 PMID:11812690 PMID:21589914 PMID:24098468 NCBI chr 2:165,949,379...166,069,510
Ensembl chr 2:165,947,521...166,069,510 		JBrowse link
G Gria3 glutamate ionotropic receptor AMPA type subunit 3 decreases expression
multiple interactions
increases expression		 EXP
ISO		 Kainic Acid results in decreased expression of GRIA3 mRNA
celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIA3 mRNA]
Kainic Acid results in increased expression of GRIA3 mRNA		 CTD PMID:7529610 PMID:21589914 NCBI chr  X:120,238,515...120,504,106
Ensembl chr  X:120,238,534...120,504,096 		JBrowse link
G Gria4 glutamate ionotropic receptor AMPA type subunit 4 decreases expression
multiple interactions		 ISO Kainic Acid results in decreased expression of GRIA4 mRNA
celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIA4 mRNA]		 CTD PMID:21589914 NCBI chr 8:1,562,118...2,035,035
Ensembl chr 8:1,562,119...2,034,979 		JBrowse link
G Grik1 glutamate ionotropic receptor kainate type subunit 1 decreases expression
increases expression
multiple interactions		 ISO Kainic Acid results in decreased expression of GRIK1 mRNA
Kainic Acid results in increased expression of GRIK1 mRNA
Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIK1 mRNA]; PTGS2 affects the reaction [Kainic Acid results in decreased expression of GRIK1 mRNA]		 CTD PMID:21589914 PMID:29208536 NCBI chr11:27,169,739...27,571,131
Ensembl chr11:27,169,740...27,570,645 		JBrowse link
G Grik2 glutamate ionotropic receptor kainate type subunit 2 increases expression
multiple interactions		 ISO Kainic Acid results in increased expression of GRIK2 mRNA
[Celecoxib co-treated with Kainic Acid] results in decreased expression of GRIK2 mRNA		 CTD PMID:17997037 PMID:21589914 PMID:29208536 NCBI chr20:52,135,325...52,833,061
Ensembl chr20:52,133,851...52,838,375 		JBrowse link
G Grik3 glutamate ionotropic receptor kainate type subunit 3 decreases expression
multiple interactions		 ISO Kainic Acid results in decreased expression of GRIK3 mRNA
[Celecoxib co-treated with Kainic Acid] results in decreased expression of GRIK3 mRNA		 CTD PMID:21589914 NCBI chr 5:137,767,865...137,989,617
Ensembl chr 5:137,767,865...137,984,307 		JBrowse link
G Grik4 glutamate ionotropic receptor kainate type subunit 4 multiple interactions
decreases expression		 ISO [Celecoxib co-treated with Kainic Acid] results in decreased expression of GRIK4 mRNA; Kainic Acid promotes the reaction [cyanoginosin LR affects the localization of GRIK4 protein]
Kainic Acid results in decreased expression of GRIK4 mRNA		 CTD PMID:21589914 PMID:34352349 NCBI chr 8:42,903,043...43,331,990
Ensembl chr 8:42,905,056...43,193,751 		JBrowse link
G Grik5 glutamate ionotropic receptor kainate type subunit 5 multiple interactions
decreases expression		 ISO Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIK5 mRNA]; PTGS2 affects the reaction [Kainic Acid results in decreased expression of GRIK5 mRNA] CTD PMID:21589914 NCBI chr 1:80,605,878...80,667,896
Ensembl chr 1:80,605,892...80,667,125 		JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 multiple interactions
affects expression
decreases expression		 ISO
EXP		 celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIN1 mRNA]
Kainic Acid affects the expression of GRIN1		 CTD PMID:21589914 PMID:23159308 NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A decreases expression
multiple interactions		 ISO Kainic Acid results in decreased expression of GRIN2A mRNA
celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIN2A mRNA]		 CTD PMID:21589914 NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637 		JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B multiple interactions
decreases expression		 ISO celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIN2B mRNA] CTD PMID:21589914 NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279 		JBrowse link
G Grin2c glutamate ionotropic receptor NMDA type subunit 2C decreases expression
multiple interactions		 ISO Kainic Acid results in decreased expression of GRIN2C mRNA
Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIN2C mRNA]; PTGS2 affects the reaction [Kainic Acid results in decreased expression of GRIN2C mRNA]		 CTD PMID:21589914 NCBI chr10:100,488,430...100,507,083
Ensembl chr10:100,488,431...100,506,427 		JBrowse link
G Grin2d glutamate ionotropic receptor NMDA type subunit 2D decreases expression
multiple interactions		 ISO Kainic Acid results in decreased expression of GRIN2D mRNA
Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIN2D mRNA]; PTGS2 affects the reaction [Kainic Acid results in decreased expression of GRIN2D mRNA]		 CTD PMID:21589914 NCBI chr 1:96,306,871...96,346,994
Ensembl chr 1:96,308,365...96,344,793 		JBrowse link
G Grin3a glutamate ionotropic receptor NMDA type subunit 3A multiple interactions
decreases expression		 ISO Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIN3A mRNA]; PTGS2 affects the reaction [Kainic Acid results in decreased expression of GRIN3A mRNA] CTD PMID:21589914 NCBI chr 5:64,006,847...64,206,408
Ensembl chr 5:64,009,980...64,206,085 		JBrowse link
G Grin3b glutamate ionotropic receptor NMDA type subunit 3B decreases expression
multiple interactions		 ISO Kainic Acid results in decreased expression of GRIN3B mRNA
celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIN3B mRNA]		 CTD PMID:21589914 NCBI chr 7:9,730,861...9,737,183
Ensembl chr 7:9,730,862...9,737,183 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases activity
decreases phosphorylation
multiple interactions		 ISO Kainic Acid results in decreased activity of GSK3B protein
Kainic Acid results in decreased phosphorylation of GSK3B protein
4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione inhibits the reaction [Kainic Acid results in decreased phosphorylation of GSK3B protein]; 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione promotes the reaction [Valproic Acid inhibits the reaction [Kainic Acid results in decreased phosphorylation of GSK3B protein]]; Valproic Acid inhibits the reaction [Kainic Acid results in decreased phosphorylation of GSK3B protein]		 CTD PMID:18619545 PMID:25453207 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
decreases activity		 EXP oridonin inhibits the reaction [Kainic Acid results in decreased activity of GSR protein] CTD PMID:31430510 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Hcn1 hyperpolarization-activated cyclic nucleotide-gated potassium channel 1 multiple interactions
decreases expression		 EXP Kainic Acid promotes the reaction [REST protein binds to HCN1 intron]; REST mutant form inhibits the reaction [Kainic Acid promotes the reaction [REST protein binds to HCN1 intron]]; REST mutant form inhibits the reaction [Kainic Acid results in decreased expression of HCN1 mRNA]; REST mutant form inhibits the reaction [Kainic Acid results in decreased expression of HCN1 protein]
Kainic Acid results in decreased expression of HCN1 mRNA; Kainic Acid results in decreased expression of HCN1 protein		 CTD PMID:21905079 NCBI chr 2:49,495,771...49,899,983
Ensembl chr 2:49,495,771...49,899,774 		JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions
increases expression		 EXP Kainic Acid results in increased expression of and affects the localization of HMGB1 protein; perampanel inhibits the reaction [Kainic Acid results in increased expression of and affects the localization of HMGB1 protein]
Kainic Acid results in increased expression of HMGB1 mRNA		 CTD PMID:36669621 NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP Kainic Acid results in increased expression of HMOX1 mRNA CTD PMID:7655348 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Homer1 homer scaffold protein 1 increases expression EXP Kainic Acid results in increased expression of HOMER1 mRNA CTD PMID:19700661 NCBI chr 2:24,542,777...24,645,715
Ensembl chr 2:24,543,093...24,644,785 		JBrowse link
G Hpca hippocalcin decreases response to substance ISO HPCA protein results in decreased susceptibility to Kainic Acid CTD PMID:15607944 NCBI chr 5:141,455,616...141,466,252
Ensembl chr 5:141,455,613...141,463,841 		JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 decreases expression ISO Kainic Acid results in decreased expression of HSD11B1 mRNA CTD PMID:17997037 NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A multiple interactions ISO [Kainic Acid co-treated with dihydroxyethyldithiocarbamate] results in increased expression of HSPA1A protein; Dizocilpine Maleate inhibits the reaction [[Kainic Acid co-treated with dihydroxyethyldithiocarbamate] results in increased expression of HSPA1A protein]; GYKI 52466 inhibits the reaction [[Kainic Acid co-treated with dihydroxyethyldithiocarbamate] results in increased expression of HSPA1A protein] CTD PMID:16686654 NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227 		JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 decreases expression ISO Kainic Acid results in decreased expression of IDI1 mRNA CTD PMID:17997037 NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357 		JBrowse link
G Il10 interleukin 10 decreases expression EXP Kainic Acid results in decreased expression of IL10 protein CTD PMID:15591643 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il12a interleukin 12A affects response to substance ISO IL12A protein affects the susceptibility to Kainic Acid CTD PMID:15474355 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734 		JBrowse link
G Il1b interleukin 1 beta increases secretion
increases expression
multiple interactions		 EXP
ISO		 Kainic Acid results in increased secretion of IL1B protein
Kainic Acid results in increased expression of IL1B mRNA; Kainic Acid results in increased expression of IL1B protein
PTGS2 affects the reaction [Kainic Acid results in increased expression of IL1B mRNA]
Minocycline inhibits the reaction [Kainic Acid results in increased secretion of IL1B protein]; oridonin inhibits the reaction [Kainic Acid results in increased expression of IL1B protein]; perampanel inhibits the reaction [Kainic Acid results in increased expression of IL1B protein]		 CTD PMID:7655348 PMID:11306611 PMID:21589914 PMID:31430510 PMID:36669621 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 increases response to substance
multiple interactions
increases expression		 ISO
EXP		 IL6 protein results in increased susceptibility to Kainic Acid
oridonin inhibits the reaction [Kainic Acid results in increased expression of IL6 protein]
Kainic Acid results in increased expression of IL6 mRNA
PTGS2 affects the reaction [Kainic Acid results in increased expression of IL6 mRNA]		 CTD PMID:12836160 PMID:21589914 PMID:31430510 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Itgam integrin subunit alpha M increases expression
multiple interactions		 ISO Kainic Acid results in increased expression of ITGAM mRNA
PTGS2 affects the reaction [Kainic Acid results in increased expression of ITGAM mRNA]		 CTD PMID:21589914 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G Jagn1 jagunal homolog 1 decreases expression ISO Kainic Acid results in decreased expression of JAGN1 mRNA CTD PMID:17997037 NCBI chr 4:146,591,577...146,596,287
Ensembl chr 4:146,591,510...146,596,288 		JBrowse link
G Jak2 Janus kinase 2 multiple interactions
decreases expression		 ISO
EXP		 EPO protein inhibits the reaction [Kainic Acid results in decreased expression of JAK2 protein]; EPOR protein promotes the reaction [EPO protein inhibits the reaction [Kainic Acid results in decreased expression of JAK2 protein]] CTD PMID:18711747 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression		 EXP [Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]; [diacetylcurcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]; Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]; Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN protein]; Diazepam inhibits the reaction [Kainic Acid results in increased expression of JUN protein]; dimemorfan inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]; dimemorfan inhibits the reaction [Kainic Acid results in increased expression of JUN protein]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN protein]]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of JUN protein]]; Pentobarbital inhibits the reaction [Kainic Acid results in increased expression of JUN protein]; SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]]; SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN protein]]; SIGMAR1 protein affects the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]]; SIGMAR1 protein affects the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of JUN protein]]; Valproic Acid inhibits the reaction [Kainic Acid results in increased expression of JUN protein]
Kainic Acid results in increased expression of JUN mRNA; Kainic Acid results in increased expression of JUN protein		 CTD PMID:8417141 PMID:15723099 PMID:17827730 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit decreases expression
increases expression		 ISO
EXP		 Kainic Acid results in decreased expression of JUNB mRNA
Kainic Acid results in increased expression of JUNB mRNA		 CTD PMID:17997037 PMID:19700661 NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035 		JBrowse link
G Kalrn kalirin, RhoGEF kinase increases expression EXP Kainic Acid results in increased expression of KALRN mRNA CTD PMID:19700661 NCBI chr11:66,198,155...66,803,166
Ensembl chr11:66,198,173...66,797,610 		JBrowse link
G Kcnc2 potassium voltage-gated channel subfamily C member 2 increases expression EXP Kainic Acid results in increased expression of KCNC2 protein CTD PMID:7643197 NCBI chr 7:47,700,035...47,883,979
Ensembl chr 7:47,700,288...47,883,968 		JBrowse link
G Kcnc4 potassium voltage-gated channel subfamily C member 4 decreases expression EXP Kainic Acid results in decreased expression of KCNC4 protein CTD PMID:21905079 NCBI chr 2:195,063,967...195,100,244
Ensembl chr 2:195,071,769...195,099,233 		JBrowse link
G Kcnq2 potassium voltage-gated channel subfamily Q member 2 increases response to substance ISO KCNQ2 protein mutant form results in increased susceptibility to Kainic Acid CTD PMID:26910900 NCBI chr 3:168,194,776...168,253,831
Ensembl chr 3:168,195,357...168,275,071 		JBrowse link
G Kif20a kinesin family member 20A decreases expression ISO Kainic Acid results in decreased expression of KIF20A mRNA CTD PMID:17997037 NCBI chr18:26,230,294...26,238,780
Ensembl chr18:26,230,230...26,238,780 		JBrowse link
G Klf10 KLF transcription factor 10 decreases expression ISO Kainic Acid results in decreased expression of KLF10 mRNA CTD PMID:17997037 NCBI chr 7:69,467,658...69,473,726
Ensembl chr 7:69,465,619...69,473,994 		JBrowse link
G Kng1 kininogen 1 multiple interactions EXP Kainic Acid promotes the reaction [Nicotine results in decreased activity of KNG1 protein alternative form] CTD PMID:7807204 NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555 		JBrowse link
G Kras KRAS proto-oncogene, GTPase increases expression EXP Kainic Acid results in increased expression of KRAS mRNA CTD PMID:19700661 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Lep leptin decreases response to substance ISO LEP protein results in decreased susceptibility to Kainic Acid CTD PMID:17993459 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Lmo1 LIM domain only 1 decreases expression ISO Kainic Acid results in decreased expression of LMO1 mRNA CTD PMID:17997037 NCBI chr 1:163,132,338...163,168,521
Ensembl chr 1:163,132,339...163,168,522 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases expression		 EXP NADP inhibits the reaction [Kainic Acid results in increased expression of MAP1LC3B protein modified form] CTD PMID:32057834 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 		JBrowse link
G Map2 microtubule-associated protein 2 multiple interactions
increases expression		 ISO PTGS2 affects the reaction [Kainic Acid results in increased expression of MAP2 mRNA] CTD PMID:21589914 NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 decreases expression ISO Kainic Acid results in decreased expression of MAP3K5 mRNA CTD PMID:17997037 NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions		 ISO Kainic Acid results in increased phosphorylation of MAPK1 protein
cyanoginosin LR promotes the reaction [Kainic Acid results in increased phosphorylation of MAPK1 protein]		 CTD PMID:34352349 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases expression
increases phosphorylation
multiple interactions		 ISO Kainic Acid results in increased expression of MAPK3 mRNA
Kainic Acid results in increased phosphorylation of MAPK3 protein
cyanoginosin LR promotes the reaction [Kainic Acid results in increased phosphorylation of MAPK3 protein]		 CTD PMID:17997037 PMID:34352349 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mast3 microtubule associated serine/threonine kinase 3 decreases expression ISO Kainic Acid results in decreased expression of MAST3 mRNA CTD PMID:17997037 NCBI chr16:18,636,764...18,663,852
Ensembl chr16:18,636,787...18,663,852 		JBrowse link
G Mmp9 matrix metallopeptidase 9 increases activity
multiple interactions		 ISO Kainic Acid results in increased activity of MMP9 protein
MMP9 protein affects the reaction [Kainic Acid results in decreased expression of NCAM1 protein modified form]		 CTD PMID:30772382 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mpdz multiple PDZ domain crumbs cell polarity complex component affects response to substance ISO MPDZ protein affects the susceptibility to Kainic Acid CTD PMID:14960011 NCBI chr 5:95,766,112...95,920,531
Ensembl chr 5:95,766,118...95,920,499 		JBrowse link
G Mpeg1 macrophage expressed 1 increases expression ISO Kainic Acid results in increased expression of MPEG1 mRNA CTD PMID:17997037 NCBI chr 1:209,452,176...209,456,692
Ensembl chr 1:209,452,133...209,458,855 		JBrowse link
G Msmo1 methylsterol monooxygenase 1 decreases expression ISO Kainic Acid results in decreased expression of MSMO1 mRNA CTD PMID:17997037 NCBI chr16:24,980,680...24,997,927
Ensembl chr16:24,980,697...24,998,016 		JBrowse link
G Mt1 metallothionein 1 increases expression
decreases response to substance		 EXP
ISO		 Kainic Acid results in increased expression of MT1A mRNA
MT1 protein results in decreased susceptibility to Kainic Acid		 CTD PMID:7655348 PMID:10947810 NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049 		JBrowse link
G Mt2A metallothionein 2A decreases response to substance ISO MT2 protein results in decreased susceptibility to Kainic Acid CTD PMID:10947810 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784 		JBrowse link
G Myo5b myosin Vb decreases expression ISO Kainic Acid results in decreased expression of MYO5B mRNA CTD PMID:17997037 NCBI chr18:68,038,759...68,341,568
Ensembl chr18:68,038,759...68,338,745 		JBrowse link
G Myo9a myosin IXA increases expression ISO Kainic Acid results in increased expression of MYO9A mRNA CTD PMID:17997037 NCBI chr 8:60,149,234...60,352,330
Ensembl chr 8:60,149,234...60,350,514 		JBrowse link
G Naip6 NLR family, apoptosis inhibitory protein 6 increases expression EXP
ISO		 Kainic Acid results in increased expression of NAIP mRNA; Kainic Acid results in increased expression of NAIP protein CTD PMID:12547647 PMID:15046874 NCBI chr 2:31,507,423...31,559,098
Ensembl chr 2:31,507,424...31,570,542 		JBrowse link
G Ncam1 neural cell adhesion molecule 1 decreases expression
multiple interactions		 EXP
ISO		 Kainic Acid results in decreased expression of NCAM1 mRNA
MMP9 protein affects the reaction [Kainic Acid results in decreased expression of NCAM1 protein modified form]		 CTD PMID:19700661 PMID:30772382 NCBI chr 8:49,865,629...50,165,687
Ensembl chr 8:49,865,633...50,166,014 		JBrowse link
G Nefl neurofilament light chain increases secretion EXP Kainic Acid results in increased secretion of NEFL protein CTD PMID:34677616 NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects localization ISO Kainic Acid affects the localization of NFE2L2 protein CTD PMID:18619545 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions
increases expression
decreases expression		 EXP 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Kainic Acid results in decreased expression of NOS1 protein]
Kainic Acid results in increased expression of NOS1 mRNA; Kainic Acid results in increased expression of NOS1 protein		 CTD PMID:17585341 PMID:18375135 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945 		JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions		 ISO
EXP		 Kainic Acid results in increased expression of NOS2 mRNA
Kainic Acid results in increased expression of NOS2 mRNA; Kainic Acid results in increased expression of NOS2 protein
PTGS2 affects the reaction [Kainic Acid results in increased expression of NOS2 mRNA]
[Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of NOS2 mRNA]; [diacetylcurcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of NOS2 mRNA]; Curcumin inhibits the reaction [Kainic Acid results in increased expression of NOS2 mRNA]		 CTD PMID:17827730 PMID:18375135 PMID:21589914 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Npy neuropeptide Y decreases response to substance
multiple interactions
increases expression		 ISO
EXP		 NPY protein results in decreased susceptibility to Kainic Acid
Thiopental inhibits the reaction [Kainic Acid results in increased expression of NPY mRNA]		 CTD PMID:9427505 PMID:15451008 NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495 		JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 decreases expression
increases expression		 ISO
EXP		 Kainic Acid results in decreased expression of NR4A1 mRNA
Kainic Acid results in increased expression of NR4A1 mRNA		 CTD PMID:17997037 PMID:19700661 NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297 		JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 increases expression EXP
ISO		 Kainic Acid results in increased expression of NR4A2 mRNA
Kainic Acid results in increased expression of NR4A2 protein		 CTD PMID:19700661 PMID:24813937 NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877 		JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 increases expression EXP Kainic Acid results in increased expression of NR4A3 mRNA CTD PMID:19700661 NCBI chr 5:62,361,588...62,401,489
Ensembl chr 5:62,361,822...62,402,733 		JBrowse link
G Nrp2 neuropilin 2 affects response to substance ISO NRP2 protein affects the susceptibility to Kainic Acid CTD PMID:18657176 NCBI chr 9:64,122,815...64,238,007
Ensembl chr 9:64,123,132...64,237,958 		JBrowse link
G Ntn1 netrin 1 increases expression EXP Kainic Acid results in increased expression of NTN1 mRNA CTD PMID:19700661 NCBI chr10:52,899,933...53,098,591
Ensembl chr10:52,899,934...53,085,326 		JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 increases expression EXP Kainic Acid results in increased expression of NTRK2 mRNA CTD PMID:19700661 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136 		JBrowse link
G Nudcd2 NudC domain containing 2 increases expression ISO Kainic Acid results in increased expression of NUDCD2 mRNA CTD PMID:17997037 NCBI chr10:25,163,247...25,168,738
Ensembl chr10:25,163,220...25,168,738 		JBrowse link
G Nudt4 nudix hydrolase 4 increases expression ISO Kainic Acid results in increased expression of NUDT4 mRNA CTD PMID:17997037 NCBI chr 7:30,188,100...30,204,615
Ensembl chr 7:30,188,100...30,204,615 		JBrowse link
G Otx2 orthodenticle homeobox 2 decreases expression EXP Kainic Acid results in decreased expression of OTX2 mRNA CTD PMID:19700661 NCBI chr15:21,942,233...21,953,034
Ensembl chr15:21,943,191...21,953,416 		JBrowse link
G Pak3 p21 (RAC1) activated kinase 3 decreases expression EXP Kainic Acid results in decreased expression of PAK3 mRNA CTD PMID:19700661 NCBI chr  X:107,116,308...107,374,342
Ensembl chr  X:107,260,898...107,368,314 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases activity EXP Kainic Acid results in increased activity of PARP1 protein CTD PMID:28704930 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pdyn prodynorphin multiple interactions
affects expression
increases expression		 EXP Diazepam inhibits the reaction [Kainic Acid results in increased expression of PDYN mRNA]; Kainic Acid results in decreased cleavage of and results in decreased secretion of PDYN protein; Pentobarbital inhibits the reaction [Kainic Acid results in increased expression of PDYN mRNA]; Valproic Acid inhibits the reaction [Kainic Acid results in increased expression of PDYN mRNA]
Kainic Acid affects the expression of PDYN mRNA		 CTD PMID:1465197 PMID:8417141 NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334 		JBrowse link
G Penk proenkephalin multiple interactions
increases expression		 EXP Diazepam inhibits the reaction [Kainic Acid results in increased expression of PENK mRNA]; Pentobarbital inhibits the reaction [Kainic Acid results in increased expression of PENK mRNA]; Thiopental inhibits the reaction [Kainic Acid results in increased expression of PENK mRNA]; Valproic Acid inhibits the reaction [Kainic Acid results in increased expression of PENK mRNA] CTD PMID:8417141 PMID:9427505 NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129 		JBrowse link
G Pick1 protein interacting with PRKCA 1 decreases expression ISO Kainic Acid results in decreased expression of PICK1 mRNA CTD PMID:17997037 NCBI chr 7:110,796,623...110,816,850
Ensembl chr 7:110,797,117...110,816,848 		JBrowse link
G Pkp2 plakophilin 2 decreases expression ISO Kainic Acid results in decreased expression of PKP2 mRNA CTD PMID:17997037 NCBI chr11:84,661,783...84,727,730
Ensembl chr11:84,661,783...84,727,730 		JBrowse link
G Plod3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 decreases expression ISO Kainic Acid results in decreased expression of PLOD3 mRNA CTD PMID:17997037 NCBI chr12:19,676,384...19,686,945
Ensembl chr12:19,676,386...19,686,960 		JBrowse link
G Ppif peptidylprolyl isomerase F increases response to substance ISO PPIF results in increased susceptibility to Kainic Acid CTD PMID:21378209 NCBI chr16:1,257,197...1,263,919
Ensembl chr16:1,257,106...1,263,913 		JBrowse link
G Ppp1r9b protein phosphatase 1, regulatory subunit 9B increases expression EXP Kainic Acid results in increased expression of PPP1R9B protein CTD PMID:17443789 NCBI chr10:79,938,055...79,954,085
Ensembl chr10:79,938,066...79,954,083 		JBrowse link
G Prkcd protein kinase C, delta multiple interactions ISO [cyanoginosin LR co-treated with Kainic Acid] results in increased phosphorylation of PRKCD protein CTD PMID:34352349 NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases response to substance
increases expression		 EXP
ISO		 [Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of PTGS2 mRNA]; [diacetylcurcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of PTGS2 mRNA]; oridonin inhibits the reaction [Kainic Acid results in increased expression of PTGS2 protein]
[PTGS2 gene mutant form results in increased susceptibility to Kainic Acid] which results in increased abundance of Dinoprost; [PTGS2 gene mutant form results in increased susceptibility to Kainic Acid] which results in increased abundance of Dinoprostone; [PTGS2 gene mutant form results in increased susceptibility to Kainic Acid] which results in increased abundance of Prostaglandin D2; [PTGS2 gene mutant form results in increased susceptibility to Kainic Acid] which results in increased abundance of Thromboxane B2; PTGS2 affects the reaction [Kainic Acid results in decreased expression of GRIA1 mRNA]; PTGS2 affects the reaction [Kainic Acid results in decreased expression of GRIK1 mRNA]; PTGS2 affects the reaction [Kainic Acid results in decreased expression of GRIK5 mRNA]; PTGS2 affects the reaction [Kainic Acid results in decreased expression of GRIN2C mRNA]; PTGS2 affects the reaction [Kainic Acid results in decreased expression of GRIN2D mRNA]; PTGS2 affects the reaction [Kainic Acid results in decreased expression of GRIN3A mRNA]; PTGS2 affects the reaction [Kainic Acid results in increased expression of GFAP mRNA]; PTGS2 affects the reaction [Kainic Acid results in increased expression of IL1B mRNA]; PTGS2 affects the reaction [Kainic Acid results in increased expression of IL6 mRNA]; PTGS2 affects the reaction [Kainic Acid results in increased expression of ITGAM mRNA]; PTGS2 affects the reaction [Kainic Acid results in increased expression of MAP2 mRNA]; PTGS2 affects the reaction [Kainic Acid results in increased expression of NOS2 mRNA]; PTGS2 affects the reaction [Kainic Acid results in increased expression of RELA mRNA]; PTGS2 affects the reaction [Kainic Acid results in increased expression of TNF mRNA]
Kainic Acid results in increased expression of PTGS2; Kainic Acid results in increased expression of PTGS2 mRNA; Kainic Acid results in increased expression of PTGS2 protein		 CTD PMID:11168565 PMID:12618123 PMID:17827730 PMID:18834901 PMID:19700661 More... NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Qki QKI, KH domain containing RNA binding increases expression ISO Kainic Acid results in increased expression of QKI mRNA CTD PMID:17997037 NCBI chr 1:50,387,716...50,501,568
Ensembl chr 1:50,387,698...50,498,831 		JBrowse link
G Rac1 Rac family small GTPase 1 increases expression EXP Kainic Acid results in increased expression of RAC1 mRNA CTD PMID:19700661 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251 		JBrowse link
G Rad23a RAD23 homolog A, nucleotide excision repair protein increases expression EXP Kainic Acid results in increased expression of RAD23A mRNA CTD PMID:19700661 NCBI chr19:23,313,563...23,320,702
Ensembl chr19:23,314,797...23,320,695 		JBrowse link
G Rasd1 ras related dexamethasone induced 1 decreases expression ISO Kainic Acid results in decreased expression of RASD1 mRNA CTD PMID:17997037 NCBI chr10:44,766,451...44,775,773
Ensembl chr10:44,766,455...44,768,186 		JBrowse link
G Rbfox1 RNA binding fox-1 homolog 1 increases response to substance ISO RBFOX1 gene mutant form results in increased susceptibility to Kainic Acid CTD PMID:21623373 NCBI chr10:8,152,198...10,248,120
Ensembl chr10:8,152,198...9,686,659 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases expression		 ISO PTGS2 affects the reaction [Kainic Acid results in increased expression of RELA mRNA] CTD PMID:21589914 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rest RE1-silencing transcription factor increases expression
multiple interactions		 EXP Kainic Acid results in increased expression of REST protein
Kainic Acid promotes the reaction [REST protein binds to HCN1 intron]; REST mutant form inhibits the reaction [Kainic Acid promotes the reaction [REST protein binds to HCN1 intron]]; REST mutant form inhibits the reaction [Kainic Acid results in decreased expression of HCN1 mRNA]; REST mutant form inhibits the reaction [Kainic Acid results in decreased expression of HCN1 protein]		 CTD PMID:21905079 NCBI chr14:30,859,109...30,879,828
Ensembl chr14:30,862,553...30,894,354 		JBrowse link
G Rgs16 regulator of G-protein signaling 16 decreases expression ISO Kainic Acid results in decreased expression of RGS16 mRNA CTD PMID:17997037 NCBI chr13:65,887,668...65,892,862
Ensembl chr13:65,887,530...65,892,857 		JBrowse link
G Rhoa ras homolog family member A increases expression EXP Kainic Acid results in increased expression of RHOA mRNA CTD PMID:19700661 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746 		JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 decreases expression ISO Kainic Acid results in decreased expression of S1PR1 mRNA CTD PMID:17997037 NCBI chr 2:203,624,752...203,629,110
Ensembl chr 2:203,621,587...203,629,681 		JBrowse link
G Sap30l SAP30-like decreases expression ISO Kainic Acid results in decreased expression of SAP30L mRNA CTD PMID:17997037 NCBI chr10:41,979,730...41,992,307
Ensembl chr10:41,979,687...41,987,658 		JBrowse link
G Sema4d semaphorin 4D increases expression EXP Kainic Acid results in increased expression of SEMA4D mRNA CTD PMID:19700661 NCBI chr17:13,430,324...13,537,146
Ensembl chr17:13,430,379...13,537,138 		JBrowse link
G Serpine1 serpin family E member 1 multiple interactions
increases expression		 ISO Guanethidine inhibits the reaction [Kainic Acid results in increased expression of SERPINE1 mRNA]; Mecamylamine inhibits the reaction [Kainic Acid results in increased expression of SERPINE1 mRNA]; Phentolamine inhibits the reaction [Kainic Acid results in increased expression of SERPINE1 mRNA] CTD PMID:15850565 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Sfpq splicing factor proline and glutamine rich increases expression ISO Kainic Acid results in increased expression of SFPQ mRNA CTD PMID:17997037 NCBI chr 5:139,338,034...139,353,476
Ensembl chr 5:139,338,075...139,353,472 		JBrowse link
G Sigmar1 sigma non-opioid intracellular receptor 1 multiple interactions EXP SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]]; SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS protein]]; SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]]; SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN protein]]; SIGMAR1 protein affects the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]]; SIGMAR1 protein affects the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of FOS protein]]; SIGMAR1 protein affects the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]]; SIGMAR1 protein affects the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of JUN protein]] CTD PMID:15723099 NCBI chr 5:56,904,155...56,907,012
Ensembl chr 5:56,904,159...56,907,017 		JBrowse link
G Sirt1 sirtuin 1 decreases expression
increases expression		 ISO
EXP		 Kainic Acid results in decreased expression of SIRT1 protein
Kainic Acid results in increased expression of SIRT1 protein		 CTD PMID:18538940 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Slc11a2 solute carrier family 11 member 2 increases expression EXP Kainic Acid results in increased expression of SLC11A2 CTD PMID:16552559 NCBI chr 7:131,503,076...131,540,246
Ensembl chr 7:131,503,081...131,540,145 		JBrowse link
G Slc1a1 solute carrier family 1 member 1 decreases expression ISO Kainic Acid results in decreased expression of SLC1A1 mRNA CTD PMID:17997037 NCBI chr 1:226,549,932...226,631,925
Ensembl chr 1:226,549,842...226,630,402 		JBrowse link
G Slc1a2 solute carrier family 1 member 2 multiple interactions
increases expression		 ISO
EXP		 [Kainic Acid co-treated with zinc chloride] results in decreased expression of SLC1A2 protein
Ceftriaxone promotes the reaction [Kainic Acid results in increased expression of SLC1A2 protein]		 CTD PMID:19061913 PMID:28257918 NCBI chr 3:89,005,129...89,135,469
Ensembl chr 3:89,005,129...89,126,498 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Kainic Acid inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Slc6a2 solute carrier family 6 member 2 increases response to substance ISO SLC6A2 protein results in increased susceptibility to Kainic Acid CTD PMID:15911120 NCBI chr19:14,010,292...14,055,317
Ensembl chr19:14,010,386...14,050,357 		JBrowse link
G Slc8a3 solute carrier family 8 member A3 multiple interactions
increases expression
increases cleavage		 EXP 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Kainic Acid results in increased cleavage of SLC8A3 protein]
Kainic Acid results in increased expression of SLC8A3 protein		 CTD PMID:17585341 PMID:20928830 NCBI chr 6:100,874,359...101,007,989
Ensembl chr 6:100,874,369...101,007,508 		JBrowse link
G Snrk SNF related kinase decreases expression ISO Kainic Acid results in decreased expression of SNRK mRNA CTD PMID:17997037 NCBI chr 8:121,779,704...121,833,949
Ensembl chr 8:121,793,302...121,832,323 		JBrowse link
G Sod1 superoxide dismutase 1 decreases expression ISO Kainic Acid results in decreased expression of SOD1 protein CTD PMID:29208536 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 decreases expression
increases expression		 EXP
ISO		 Kainic Acid results in decreased expression of SOD2 protein
Kainic Acid results in decreased expression of SOD2 mRNA; Kainic Acid results in decreased expression of SOD2 protein
Kainic Acid results in increased expression of SOD2 protein		 CTD PMID:10686417 PMID:29208536 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Sptan1 spectrin, alpha, non-erythrocytic 1 increases expression EXP Kainic Acid results in increased expression of SPTAN1 protein modified form CTD PMID:22790971 NCBI chr 3:13,241,164...13,306,047
Ensembl chr 3:13,241,217...13,306,046 		JBrowse link
G Sqstm1 sequestosome 1 decreases expression
multiple interactions		 EXP Kainic Acid results in decreased expression of SQSTM1 protein
NADP inhibits the reaction [Kainic Acid results in decreased expression of SQSTM1 protein]		 CTD PMID:32057834 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Sst somatostatin decreases expression ISO Kainic Acid results in decreased expression of SST mRNA CTD PMID:17997037 NCBI chr11:76,956,896...76,958,173
Ensembl chr11:76,956,896...76,958,173 		JBrowse link
G Tac1 tachykinin, precursor 1 decreases expression EXP Kainic Acid results in decreased expression of TAC1 protein CTD PMID:6205719 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178 		JBrowse link
G Tigar TP53 induced glycolysis regulatory phosphatase decreases expression
multiple interactions		 EXP Kainic Acid results in decreased expression of TIGAR protein
NADP inhibits the reaction [Kainic Acid results in decreased expression of TIGAR protein]		 CTD PMID:32057834 NCBI chr 4:159,927,136...159,946,077
Ensembl chr 4:159,927,139...159,946,029 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions
increases expression		 EXP perampanel inhibits the reaction [Kainic Acid results in increased expression of TLR4 protein]
Kainic Acid results in increased expression of TLR4 mRNA; Kainic Acid results in increased expression of TLR4 protein		 CTD PMID:36669621 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression		 ISO
EXP		 PTGS2 affects the reaction [Kainic Acid results in increased expression of TNF mRNA]; TNF protein promotes the reaction [Kainic Acid results in increased uptake of Cobalt]
oridonin inhibits the reaction [Kainic Acid results in increased expression of TNF protein]
Kainic Acid results in increased expression of TNF mRNA; Kainic Acid results in increased expression of TNF protein		 CTD PMID:15869941 PMID:19700661 PMID:21589914 PMID:31430510 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 increases expression EXP Kainic Acid results in increased expression of TP53 protein CTD PMID:20955365 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Trh thyrotropin releasing hormone decreases expression
increases expression		 EXP Kainic Acid results in decreased expression of TRH mRNA
Kainic Acid results in increased expression of TRH mRNA		 CTD PMID:10443546 NCBI chr 4:124,742,111...124,777,094
Ensembl chr 4:124,742,111...124,744,637 		JBrowse link
G Trhr thyrotropin releasing hormone receptor decreases expression EXP Kainic Acid results in decreased expression of TRHR protein CTD PMID:10443546 NCBI chr 7:75,348,672...75,393,310
Ensembl chr 7:75,348,672...75,393,309 		JBrowse link
G Tyrobp transmembrane immune signaling adaptor Tyrobp increases expression ISO Kainic Acid results in increased expression of TYROBP mRNA CTD PMID:17997037 NCBI chr 1:85,672,931...85,676,856
Ensembl chr 1:85,672,994...85,676,848 		JBrowse link
G Uchl1 ubiquitin C-terminal hydrolase L1 increases expression EXP Kainic Acid results in increased expression of UCHL1 protein CTD PMID:22790971 NCBI chr14:41,485,031...41,495,590
Ensembl chr14:41,485,031...41,495,590 		JBrowse link
G Uhmk1 U2AF homology motif kinase 1 decreases expression ISO Kainic Acid results in decreased expression of UHMK1 mRNA CTD PMID:17997037 NCBI chr13:82,396,646...82,416,292
Ensembl chr13:82,401,187...82,416,292 		JBrowse link
G Uri1 URI1, prefoldin-like chaperone increases expression ISO Kainic Acid results in increased expression of URI1 mRNA CTD PMID:17997037 NCBI chr 1:90,646,392...90,704,811
Ensembl chr 1:90,646,393...90,709,026 		JBrowse link
G Utp3 UTP3, small subunit processome component decreases expression ISO Kainic Acid results in decreased expression of UTP3 mRNA CTD PMID:17997037 NCBI chr14:19,515,716...19,517,370
Ensembl chr14:19,515,669...19,517,396 		JBrowse link
G Vamp7 vesicle-associated membrane protein 7 decreases expression EXP Kainic Acid results in decreased expression of VAMP7 mRNA CTD PMID:19700661 NCBI chr12:16,728,486...16,764,261
Ensembl chr12:16,728,524...16,764,097 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Kainic Acid results in decreased expression of VEGFA mRNA CTD PMID:17997037 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Wfs1 wolframin ER transmembrane glycoprotein increases expression ISO Kainic Acid results in increased expression of WFS1 mRNA CTD PMID:17997037 NCBI chr14:73,810,478...73,834,993
Ensembl chr14:73,810,404...73,835,602 		JBrowse link
G Xpa XPA, DNA damage recognition and repair factor increases expression EXP Kainic Acid results in increased expression of XPA mRNA CTD PMID:19700661 NCBI chr 5:60,431,673...60,475,726
Ensembl chr 5:60,431,673...60,475,726 		JBrowse link
G Zcchc7 zinc finger CCHC-type containing 7 increases expression ISO Kainic Acid results in increased expression of ZCCHC7 mRNA CTD PMID:17997037 NCBI chr 5:58,992,558...59,173,308
Ensembl chr 5:58,993,290...59,173,300 		JBrowse link
lincomycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mr1 major histocompatibility complex, class I-related affects expression ISO Lincomycin affects the expression of MR1 mRNA CTD PMID:25811541 NCBI chr13:67,298,362...67,317,985
Ensembl chr13:67,299,585...67,317,970 		JBrowse link
G RT1-A2 RT1 class Ia, locus A2 affects expression ISO Lincomycin affects the expression of HLA-E mRNA CTD PMID:25811541 NCBI chr20:4,870,939...4,910,183 JBrowse link
lisinopril dihydrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme decreases activity ISO Lisinopril analog results in decreased activity of ACE protein CTD PMID:22200082 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131 		JBrowse link
G Ace2 angiotensin converting enzyme 2 increases expression
multiple interactions
increases activity		 EXP
ISO		 Lisinopril results in increased expression of ACE2 mRNA
ACE2 protein affects the reaction [[[Lisinopril co-treated with Thiorphan co-treated with N-benzyloxycarbonylprolylprolinal] affects the metabolism of AGT protein] which results in decreased abundance of angiotensin I (1-7)]
Lisinopril results in increased activity of ACE2 protein		 CTD PMID:15897343 PMID:16221218 PMID:27649628 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977 		JBrowse link
G Ache acetylcholinesterase multiple interactions ISO
EXP		 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Lisinopril inhibits the reaction [Streptozocin results in increased activity of ACHE protein]]; Lisinopril inhibits the reaction [Streptozocin results in increased activity of ACHE protein]
Lisinopril inhibits the reaction [Sodium Fluoride results in decreased activity of ACHE protein]		 CTD PMID:23060470 PMID:31710167 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Agt angiotensinogen decreases expression
increases expression
affects response to substance
increases secretion
decreases secretion
multiple interactions
affects metabolic processing		 ISO
EXP		 Lisinopril results in decreased expression of AGT protein
Lisinopril results in increased expression of AGT mRNA
AGT gene alternative form affects the susceptibility to Lisinopril
Lisinopril results in increased secretion of AGT protein alternative form
Lisinopril results in decreased secretion of AGT protein
[Lisinopril co-treated with Losartan] results in increased expression of AGT mRNA
Lisinopril affects the metabolism of AGT protein
[[Lisinopril co-treated with chymostatin] affects the metabolism of AGT protein] which results in decreased abundance of Angiotensin II; [[Lisinopril co-treated with Thiorphan co-treated with N-benzyloxycarbonylprolylprolinal] affects the metabolism of AGT protein] which results in decreased abundance of angiotensin I (1-7); [[Lisinopril co-treated with Thiorphan] affects the metabolism of AGT protein] which results in decreased abundance of angiotensin I (1-7); [Lisinopril affects the metabolism of AGT protein] which results in decreased abundance of Angiotensin II; [Lisinopril co-treated with chymostatin] affects the metabolism of AGT protein; [Lisinopril co-treated with Thiorphan co-treated with N-benzyloxycarbonylprolylprolinal] affects the metabolism of AGT protein; [Lisinopril co-treated with Thiorphan] affects the metabolism of AGT protein
[[Lisinopril co-treated with Thiorphan co-treated with N-benzyloxycarbonylprolylprolinal] affects the metabolism of AGT protein] which results in decreased abundance of angiotensin I (1-7); [[Lisinopril co-treated with Thiorphan] affects the metabolism of AGT protein] which results in decreased abundance of angiotensin I (1-7); [Lisinopril affects the metabolism of AGT protein] which results in decreased abundance of Angiotensin II; [Lisinopril affects the metabolism of AGT protein] which results in increased abundance of angiotensin I (1-7); [Lisinopril co-treated with Thiorphan co-treated with N-benzyloxycarbonylprolylprolinal] affects the metabolism of AGT protein; [Lisinopril co-treated with Thiorphan] affects the metabolism of AGT protein; ACE2 protein affects the reaction [[[Lisinopril co-treated with Thiorphan co-treated with N-benzyloxycarbonylprolylprolinal] affects the metabolism of AGT protein] which results in decreased abundance of angiotensin I (1-7)]; Thiorphan inhibits the reaction [[Lisinopril affects the metabolism of AGT protein] which results in increased abundance of angiotensin I (1-7)]		 CTD PMID:8393685 PMID:8915971 PMID:15897343 PMID:16221218 PMID:16685205 More... NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Lisinopril results in decreased expression of BCL2 CTD PMID:10075388 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Cd2ap CD2-associated protein multiple interactions EXP Lisinopril inhibits the reaction [Doxorubicin results in increased expression of CD2AP protein] CTD PMID:16636307 NCBI chr 9:18,086,744...18,182,744
Ensembl chr 9:18,086,984...18,182,199 		JBrowse link
G Edn1 endothelin 1 decreases secretion ISO Lisinopril results in decreased secretion of EDN1 protein CTD PMID:19079593 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Gh1 growth hormone 1 multiple interactions EXP [Lisinopril co-treated with GH1 protein] inhibits the reaction [Doxorubicin results in decreased expression of TIMP1 protein]; [Lisinopril co-treated with GH1 protein] inhibits the reaction [Doxorubicin results in increased expression of MMP2 protein]; [Lisinopril co-treated with GH1 protein] inhibits the reaction [Doxorubicin results in increased expression of NOS2 mRNA] CTD PMID:20051877 NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions EXP Lisinopril inhibits the reaction [Doxorubicin results in increased expression of HAVCR1 mRNA]; Lisinopril inhibits the reaction [Doxorubicin results in increased expression of HAVCR1 protein] CTD PMID:19225054 NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698 		JBrowse link
G Hpse heparanase multiple interactions EXP [Spironolactone co-treated with Lisinopril] inhibits the reaction [Doxorubicin results in increased expression of HPSE protein]; Lisinopril inhibits the reaction [Doxorubicin results in increased expression of HPSE protein] CTD PMID:19429930 NCBI chr14:8,896,593...8,937,011
Ensembl chr14:8,896,593...8,937,010 		JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 increases expression ISO Lisinopril results in increased expression of IGFBP1 protein CTD PMID:9663927 NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP [Lisinopril co-treated with GH1 protein] inhibits the reaction [Doxorubicin results in increased expression of MMP2 protein]; Lisinopril inhibits the reaction [Doxorubicin results in increased expression of MMP2 protein] CTD PMID:20051877 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Lisinopril inhibits the reaction [Streptozocin results in increased activity of MPO protein]]; Lisinopril inhibits the reaction [Streptozocin results in increased activity of MPO protein] CTD PMID:23060470 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP [Lisinopril co-treated with GH1 protein] inhibits the reaction [Doxorubicin results in increased expression of NOS2 mRNA]; Lisinopril inhibits the reaction [Doxorubicin results in increased expression of NOS2 mRNA] CTD PMID:20051877 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nphs2 NPHS2 stomatin family member, podocin multiple interactions EXP Lisinopril affects the reaction [Doxorubicin results in increased expression of NPHS2 mRNA]; Lisinopril affects the reaction [Doxorubicin results in increased expression of NPHS2 protein] CTD PMID:16636307 NCBI chr13:68,448,720...68,461,312
Ensembl chr13:68,448,926...68,461,313 		JBrowse link
G Nppa natriuretic peptide A decreases expression ISO Lisinopril results in decreased expression of NPPA protein CTD PMID:8393685 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Ren renin increases expression
multiple interactions		 ISO
EXP		 Lisinopril results in increased expression of REN protein
[Lisinopril co-treated with Losartan] results in increased expression of REN mRNA
Lisinopril results in increased expression of REN mRNA		 CTD PMID:2550029 PMID:8915971 PMID:16221218 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
G RT1-M3-1 RT1 class Ib, locus M3, gene 1 affects expression ISO Lisinopril affects the expression of HLA-G mRNA CTD PMID:25811541 NCBI chr20:1,323,976...1,328,126
Ensembl chr20:1,287,521...1,328,117 		JBrowse link
G Spmip11 sperm microtubule inner protein 11 multiple interactions EXP Lisinopril inhibits the reaction [Doxorubicin results in decreased phosphorylation of NPHS1 protein]; Lisinopril inhibits the reaction [Doxorubicin results in increased expression of NPHS1 protein] CTD PMID:16636307 PMID:19293598 NCBI chr 7:129,720,950...129,742,485
Ensembl chr 7:129,720,950...129,742,485 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP [Lisinopril co-treated with GH1 protein] inhibits the reaction [Doxorubicin results in decreased expression of TIMP1 protein]; Lisinopril inhibits the reaction [Doxorubicin results in decreased expression of TIMP1 protein] CTD PMID:20051877 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP Lisinopril inhibits the reaction [Doxorubicin results in decreased expression of VEGFA protein] CTD PMID:19293598 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
maculosin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO maculosin inhibits the reaction [Diethylnitrosamine results in decreased expression of BAX protein] CTD PMID:34726822 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO maculosin inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2 protein] CTD PMID:34726822 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO maculosin inhibits the reaction [Diethylnitrosamine results in decreased expression of CASP3 mRNA]; maculosin inhibits the reaction [Diethylnitrosamine results in decreased expression of CASP3 protein] CTD PMID:34726822 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase multiple interactions ISO maculosin inhibits the reaction [Diethylnitrosamine results in decreased activity of CAT protein] CTD PMID:34726822 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO maculosin inhibits the reaction [Diethylnitrosamine results in decreased activity of GSR protein] CTD PMID:34726822 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 multiple interactions ISO maculosin inhibits the reaction [Diethylnitrosamine results in increased expression of PIK3R1 protein modified form] CTD PMID:34726822 NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
G Pten phosphatase and tensin homolog multiple interactions ISO maculosin inhibits the reaction [Diethylnitrosamine results in decreased expression of PTEN protein] CTD PMID:34726822 NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO maculosin inhibits the reaction [Diethylnitrosamine results in decreased expression of TRP53 mRNA]; maculosin inhibits the reaction [Diethylnitrosamine results in decreased expression of TRP53 protein] CTD PMID:34726822 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
royal jelly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP royal jelly inhibits the reaction [Fluorides results in decreased expression of BAX protein] CTD PMID:34227456 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO
EXP		 royal jelly inhibits the reaction [Nicotine results in decreased expression of BCL2 mRNA]
royal jelly inhibits the reaction [Fluorides results in increased expression of BCL2 protein]		 CTD PMID:30896085 PMID:34227456 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions EXP royal jelly inhibits the reaction [Fluorides results in decreased expression of BDNF protein] CTD PMID:34227456 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP		 royal jelly inhibits the reaction [Nicotine results in increased expression of CASP3 mRNA]
royal jelly inhibits the reaction [Fluorides results in decreased expression of CASP3 protein]		 CTD PMID:30896085 PMID:34227456 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp6 caspase 6 multiple interactions EXP royal jelly inhibits the reaction [Fluorides results in decreased expression of CASP6 protein] CTD PMID:34227456 NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502 		JBrowse link
G Casp9 caspase 9 multiple interactions EXP royal jelly inhibits the reaction [Fluorides results in decreased expression of CASP9 protein] CTD PMID:34227456 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase multiple interactions EXP
ISO		 royal jelly inhibits the reaction [Cisplatin results in decreased activity of CAT protein]; royal jelly inhibits the reaction [Fluorides results in decreased activity of CAT protein]
royal jelly inhibits the reaction [Nicotine results in decreased activity of CAT protein]		 CTD PMID:20369241 PMID:30896085 PMID:34227456 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO royal jelly inhibits the reaction [phenylhydrazine affects the expression of CCND1 mRNA] CTD PMID:35099105 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G E2f1 E2F transcription factor 1 multiple interactions EXP royal jelly inhibits the reaction [Paclitaxel results in increased expression of E2F1 mRNA] CTD PMID:27496854 NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
affects binding
increases activity		 ISO Estradiol inhibits the reaction [royal jelly binds to ESR1 protein]; royal jelly binds to and results in increased activity of ESR1 protein; royal jelly inhibits the reaction [Estradiol binds to ESR1 protein]
royal jelly results in increased activity of ESR1 protein		 CTD PMID:15946813 PMID:17287592 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
affects binding		 ISO Estradiol inhibits the reaction [royal jelly binds to ESR2 protein]; royal jelly binds to and results in increased activity of ESR2 protein; royal jelly inhibits the reaction [Estradiol binds to ESR2 protein] CTD PMID:15946813 PMID:17287592 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP royal jelly inhibits the reaction [Fluorides results in increased expression of GSK3B protein] CTD PMID:34227456 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Ins1 insulin 1 multiple interactions EXP royal jelly inhibits the reaction [Fructose results in increased expression of INS1 protein] CTD PMID:18981581 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
decreases expression		 ISO
EXP		 royal jelly inhibits the reaction [phenylhydrazine results in decreased expression of MYC mRNA]
royal jelly results in decreased expression of MYC mRNA
royal jelly inhibits the reaction [Paclitaxel results in decreased expression of MYC mRNA]		 CTD PMID:27496854 PMID:35099105 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP royal jelly inhibits the reaction [Fluorides results in decreased expression of NFE2L2 protein] CTD PMID:34227456 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO royal jelly inhibits the reaction [Nicotine results in decreased expression of PCNA protein] CTD PMID:30896085 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP royal jelly inhibits the reaction [Fluorides results in increased expression of RELA protein] CTD PMID:34227456 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Tff1 trefoil factor 1 increases expression ISO royal jelly results in increased expression of TFF1 mRNA CTD PMID:15946813 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO royal jelly inhibits the reaction [Nicotine results in increased expression of TRP53 mRNA] CTD PMID:30896085 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO
EXP		 royal jelly results in increased expression of VEGFA mRNA CTD PMID:15946813 PMID:17287592 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    role 19854
      biological role 19852
        osmolyte 3447
          compatible osmolytes 380
            L-proline 300
              (2S,5S)-5-amino-4-oxo-1,2,4,5,6,7-hexahydroazepino[3,2,1-hi]indole-2-carboxylic acid 0
              (E)-nesocodin (alcohol-form) zwitterion 0
              (E)-nesocodin (oxo-form) zwitterion 0
              Ala-Ala-Pro 0
              Ala-Ala-Pro-Pro 0
              Ala-Asn-Asn-Pro 0
              Ala-Asn-Asp-Pro 0
              Ala-Asp-Pro 0
              Ala-Gln-Pro 0
              Ala-Gly-Pro 0
              Ala-Leu-Ala-Pro 0
              Ala-Leu-Thr-Pro 0
              Ala-Pro 0
              Ala-Thr-Ala-Pro 0
              Ala-Val-Asp-Pro 0
              Ala-Val-Pro-Pro 0
              Arg-Pro 0
              Arg-Trp-Pro 0
              Asn-Asn-Pro-Ser 0
              Asn-Gly-Pro-His 0
              Asn-Met-Gln-Pro 0
              Asn-Pro 0
              Asp-Gly-Pro 0
              Asp-Met-Thr-Pro 0
              Asp-Pro-Ser-Ser 0
              Asp-Val-Gly-Pro 0
              Asp-Val-Pro-Pro 0
              Cys-Pro 0
              Gln-Leu-Leu-Pro 0
              Glu-Pro 0
              Gly-Arg-Pro 0
              Gly-Pro 0
              Gly-Pro-Hyp 0
              Ile-Leu-Pro 0
              L-proline derivative + 275
              L-proline residue + 0
              L-proline-d7 0
              L-prolino group + 21
              L-prolyl group 0
              Leu-Gly-Pro 0
              Leu-Pro 0
              Leu-Pro-Tyr 0
              Lys-Thr-Pro-Pro 0
              Met-Pro 0
              Phe-Ala-Pro 0
              Phe-Pro-Pro 0
              Phe-Pro-Thr 0
              Pro-Arg 0
              Pro-Arg-Pro 0
              Pro-Cys 0
              Pro-Glu-Ile 0
              Pro-Hyp 0
              Pro-Met 0
              Pro-Pro 0
              Pro-Pro-Pro 0
              Pro-Ser 0
              Pro-Thr 0
              Pro-Trp-Val-Gly 0
              Pro-Val-Gly-Pro 0
              Pro-Val-Val-Pro 0
              Ser-Asp-Lys-Pro + 16
              Thr-Pro 0
              Thr-Pro-Pro 0
              Thr-Pro-Tyr 0
              Trp-Pro 0
              Tyr-Pro 0
              Val-Asn-Pro 0
              Val-Pro + 0
              Val-Pro-Pro 0
              acromelic acid A 0
              cyclo(L-His-L-Pro) 0
              maculosin 8
              notoamide + 0
              royal jelly 20
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    main group molecular entity 19849
                      s-block molecular entity 19681
                        hydrogen molecular entity 19662
                          hydrides 19167
                            inorganic hydride 18182
                              pnictogen hydride 18172
                                nitrogen hydride 18085
                                  azane 17866
                                    ammonia 17865
                                      organic amino compound 17888
                                        amino acid 16071
                                          alpha-amino acid 13929
                                            L-alpha-amino acid 12971
                                              glutamine family amino acid 10316
                                                L-proline 300
                                                  (2S,5S)-5-amino-4-oxo-1,2,4,5,6,7-hexahydroazepino[3,2,1-hi]indole-2-carboxylic acid 0
                                                  (E)-nesocodin (alcohol-form) zwitterion 0
                                                  (E)-nesocodin (oxo-form) zwitterion 0
                                                  Ala-Ala-Pro 0
                                                  Ala-Ala-Pro-Pro 0
                                                  Ala-Asn-Asn-Pro 0
                                                  Ala-Asn-Asp-Pro 0
                                                  Ala-Asp-Pro 0
                                                  Ala-Gln-Pro 0
                                                  Ala-Gly-Pro 0
                                                  Ala-Leu-Ala-Pro 0
                                                  Ala-Leu-Thr-Pro 0
                                                  Ala-Pro 0
                                                  Ala-Thr-Ala-Pro 0
                                                  Ala-Val-Asp-Pro 0
                                                  Ala-Val-Pro-Pro 0
                                                  Arg-Pro 0
                                                  Arg-Trp-Pro 0
                                                  Asn-Asn-Pro-Ser 0
                                                  Asn-Gly-Pro-His 0
                                                  Asn-Met-Gln-Pro 0
                                                  Asn-Pro 0
                                                  Asp-Gly-Pro 0
                                                  Asp-Met-Thr-Pro 0
                                                  Asp-Pro-Ser-Ser 0
                                                  Asp-Val-Gly-Pro 0
                                                  Asp-Val-Pro-Pro 0
                                                  Cys-Pro 0
                                                  Gln-Leu-Leu-Pro 0
                                                  Glu-Pro 0
                                                  Gly-Arg-Pro 0
                                                  Gly-Pro 0
                                                  Gly-Pro-Hyp 0
                                                  Ile-Leu-Pro 0
                                                  L-proline derivative + 275
                                                  L-proline residue + 0
                                                  L-proline-d7 0
                                                  L-prolino group + 21
                                                  L-prolyl group 0
                                                  Leu-Gly-Pro 0
                                                  Leu-Pro 0
                                                  Leu-Pro-Tyr 0
                                                  Lys-Thr-Pro-Pro 0
                                                  Met-Pro 0
                                                  Phe-Ala-Pro 0
                                                  Phe-Pro-Pro 0
                                                  Phe-Pro-Thr 0
                                                  Pro-Arg 0
                                                  Pro-Arg-Pro 0
                                                  Pro-Cys 0
                                                  Pro-Glu-Ile 0
                                                  Pro-Hyp 0
                                                  Pro-Met 0
                                                  Pro-Pro 0
                                                  Pro-Pro-Pro 0
                                                  Pro-Ser 0
                                                  Pro-Thr 0
                                                  Pro-Trp-Val-Gly 0
                                                  Pro-Val-Gly-Pro 0
                                                  Pro-Val-Val-Pro 0
                                                  Ser-Asp-Lys-Pro + 16
                                                  Thr-Pro 0
                                                  Thr-Pro-Pro 0
                                                  Thr-Pro-Tyr 0
                                                  Trp-Pro 0
                                                  Tyr-Pro 0
                                                  Val-Asn-Pro 0
                                                  Val-Pro + 0
                                                  Val-Pro-Pro 0
                                                  acromelic acid A 0
                                                  cyclo(L-His-L-Pro) 0
                                                  maculosin 8
                                                  notoamide + 0
                                                  royal jelly 20
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