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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:2,5-dihydroxybenzoic acid
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Accession:CHEBI:17189 term browser browse the term
Definition:A dihydroxybenzoic acid having the two hydroxy groups at the 2- and 5-positions.
Synonyms:related_synonym: 2,5-Dihydroxybenzoate;   5-hydroxysalicylic acid;   Formula=C7H6O4;   Gentisate;   Gentisic acid;   Hydroquinonecarboxylic acid;   InChI=1S/C7H6O4/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,8-9H,(H,10,11);   InChIKey=WXTMDXOMEHJXQO-UHFFFAOYSA-N;   SMILES=OC(=O)c1cc(O)ccc1O
 alt_id: CHEBI:11451;   CHEBI:19381;   CHEBI:19382;   CHEBI:936
 xref: CAS:490-79-9;   Drug_Central:3260;   HMDB:HMDB0000152;   KEGG:C00628;   KNApSAcK:C00002648;   LINCS:LSM-19031
 xref_mesh: MESH:C010925
 xref: MetaCyc:CPD-633;   PDBeChem:GTQ;   PMID:15862799;   PMID:18314336;   PMID:22770225;   PMID:24547933;   Reaxys:2209119;   Wikipedia:Gentisic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:58044


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2,5-dihydroxybenzoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme multiple interactions ISO 2,5-dihydroxybenzoic acid inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of ACE mRNA] CTD PMID:37120126 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131 		JBrowse link
G Ace2 angiotensin converting enzyme 2 multiple interactions ISO 2,5-dihydroxybenzoic acid inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of ACE2 mRNA] CTD PMID:37120126 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions ISO 2,5-dihydroxybenzoic acid inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of AGTR1A mRNA] CTD PMID:37120126 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G App amyloid beta precursor protein multiple interactions ISO 2,5-dihydroxybenzoic acid inhibits the reaction [APP protein modified form binds to APP protein modified form]; Gallic Acid inhibits the reaction [2,5-dihydroxybenzoic acid inhibits the reaction [APP protein modified form binds to APP protein modified form]] CTD PMID:22129351 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Cat catalase multiple interactions ISO 2,5-dihydroxybenzoic acid inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased activity of CAT protein]; 2,5-dihydroxybenzoic acid inhibits the reaction [Benzoyl Peroxide results in decreased activity of CAT protein] CTD PMID:15454305 PMID:37120126 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cryz crystallin zeta multiple interactions ISO 2,5-dihydroxybenzoic acid inhibits the reaction [Benzoyl Peroxide results in decreased activity of CRYZ protein] CTD PMID:15454305 NCBI chr 2:243,552,037...243,580,369
Ensembl chr 2:243,552,119...243,579,758 		JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions ISO 2,5-dihydroxybenzoic acid inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of NOX2 mRNA] CTD PMID:37120126 NCBI chr  X:13,358,101...13,392,570
Ensembl chr  X:13,359,430...13,392,586 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase decreases activity
multiple interactions		 ISO 2,5-dihydroxybenzoic acid results in decreased activity of G6PD protein mutant form
2,5-dihydroxybenzoic acid inhibits the reaction [Benzoyl Peroxide results in decreased activity of G6PD protein]		 CTD PMID:5432368 PMID:15454305 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO 2,5-dihydroxybenzoic acid inhibits the reaction [Benzoyl Peroxide results in decreased activity of GSR protein] CTD PMID:15454305 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO 2,5-dihydroxybenzoic acid inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of IL10 mRNA]; 2,5-dihydroxybenzoic acid inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of IL10 protein] CTD PMID:37120126 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions ISO 2,5-dihydroxybenzoic acid promotes the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of KEAP1 mRNA] CTD PMID:37120126 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862 		JBrowse link
G Mir200a microRNA 200a multiple interactions ISO 2,5-dihydroxybenzoic acid promotes the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of MIR200A] CTD PMID:37120126 NCBI chr 5:166,648,494...166,648,582 JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO 2,5-dihydroxybenzoic acid promotes the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of NFE2L2 protein] CTD PMID:37120126 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO 2,5-dihydroxybenzoic acid promotes the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of NQO1 mRNA] CTD PMID:37120126 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Odc1 ornithine decarboxylase 1 multiple interactions ISO 2,5-dihydroxybenzoic acid inhibits the reaction [Benzoyl Peroxide results in increased activity of ODC1 protein] CTD PMID:15454305 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO 2,5-dihydroxybenzoic acid inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased phosphorylation of RELA protein] CTD PMID:37120126 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO 2,5-dihydroxybenzoic acid inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased activity of SOD1 protein] CTD PMID:37120126 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases activity
increases expression		 ISO
EXP		 2,5-dihydroxybenzoic acid results in increased activity of SULT1A1 protein
2,5-dihydroxybenzoic acid results in increased expression of SULT1A1 mRNA		 CTD PMID:16308312 PMID:16443358 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562 		JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 increases expression EXP 2,5-dihydroxybenzoic acid results in increased expression of SULT2A1 mRNA CTD PMID:16443358 NCBI chr 1:75,451,178...75,508,113
Ensembl chr 1:74,911,100...75,508,134 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO 2,5-dihydroxybenzoic acid inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of TGFB1 mRNA]; 2,5-dihydroxybenzoic acid inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of TGFB1 protein] CTD PMID:37120126 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO 2,5-dihydroxybenzoic acid inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of TNF mRNA]; 2,5-dihydroxybenzoic acid inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of TNF protein] CTD PMID:37120126 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    role 19854
      application 19722
        MALDI matrix material 1046
          2,5-dihydroxybenzoic acid 21
            2,5-dihydroxybenzoic acid 2-O-beta-D-glucoside 0
            2,5-dihydroxybenzoic acid 5-O-beta-D-glucoside 0
            2,5-dihydroxybenzoyl-CoA 0
            benzyl 2,5-dihydroxybenzoate 0
            mygalin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    p-block element atom 19849
                      carbon group element atom 19766
                        carbon atom 19785
                          organic molecular entity 19785
                            heteroorganic entity 19541
                              organochalcogen compound 19301
                                organooxygen compound 19193
                                  carbon oxoacid 18681
                                    carboxylic acid 18678
                                      aromatic carboxylic acid 12711
                                        benzoic acids 12688
                                          benzoic acid 5505
                                            hydroxybenzoic acid 4981
                                              dihydroxybenzoic acid 83
                                                2,5-dihydroxybenzoic acid 21
                                                  2,5-dihydroxybenzoic acid 2-O-beta-D-glucoside 0
                                                  2,5-dihydroxybenzoic acid 5-O-beta-D-glucoside 0
                                                  2,5-dihydroxybenzoyl-CoA 0
                                                  benzyl 2,5-dihydroxybenzoate 0
                                                  mygalin 0
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