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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:2,8-bis-Trifluoromethyl-4-quinoline carboxylic acid
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Accession:CHEBI:171694 term browser browse the term
Synonyms:exact_synonym: 2,8-bis(triluoromethyl)quinoline-4-carboxylic acid
 related_synonym: Formula=C12H5F6NO2;   InChI=1S/C12H5F6NO2/c13-11(14,15)7-3-1-2-5-6(10(20)21)4-8(12(16,17)18)19-9(5)7/h1-4H,(H,20,21);   InChIKey=QJTJIQBSZLFWFS-UHFFFAOYSA-N;   SMILES=FC(F)(F)C=1C=2N=C(C=C(C2C=CC1)C(O)=O)C(F)(F)F
 xref: CAS:35853-50-0;   Chemspider:148424;   HMDB:HMDB0060726
 xref_mesh: MESH:C057006



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2,8-bis-Trifluoromethyl-4-quinoline carboxylic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression ISO Ro 21-5104 results in increased expression of ABCB1 mRNA CTD PMID:25313206 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression
multiple interactions
ISO Ro 21-5104 results in increased expression of CYP2B6 mRNA; Ro 21-5104 results in increased expression of CYP2B6 protein
NR1I2 mRNA promotes the reaction [Ro 21-5104 results in increased expression of CYP2B6 mRNA]
CTD PMID:25313206 NCBI chr 1:90,780,468...90,859,852
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases expression ISO Ro 21-5104 results in increased expression of CYP2C8 mRNA CTD PMID:25313206
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
increases expression
ISO NR1I2 mRNA promotes the reaction [Ro 21-5104 results in increased expression of CYP3A4 mRNA]
Ro 21-5104 results in increased expression of CYP3A4 mRNA; Ro 21-5104 results in increased expression of CYP3A4 protein
CTD PMID:25313206 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Ephx1 epoxide hydrolase 1 increases expression ISO Ro 21-5104 results in increased expression of EPHX1 mRNA CTD PMID:25313206 NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235
JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO Ro 21-5104 promotes the reaction [NR1I2 protein binds to NCOA1 protein] CTD PMID:25313206 NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664
JBrowse link
G Ncor2 nuclear receptor co-repressor 2 multiple interactions ISO Ro 21-5104 inhibits the reaction [NR1I2 protein binds to NCOR2 protein] CTD PMID:25313206 NCBI chr12:31,466,418...31,628,319
Ensembl chr12:31,466,412...31,628,319
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO NR1I2 mRNA promotes the reaction [Ro 21-5104 results in increased expression of CYP2B6 mRNA]; NR1I2 mRNA promotes the reaction [Ro 21-5104 results in increased expression of CYP3A4 mRNA]; Ro 21-5104 binds to and results in increased activity of NR1I2 protein; Ro 21-5104 inhibits the reaction [NR1I2 protein binds to NCOR2 protein]; Ro 21-5104 promotes the reaction [NR1I2 protein binds to NCOA1 protein] CTD PMID:25313206 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases expression ISO Ro 21-5104 results in increased expression of UGT1A3 mRNA CTD PMID:25313206 NCBI chr 9:96,239,019...96,256,264
Ensembl chr 9:88,713,184...88,808,465
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19899
    chemical entity 19897
      molecular entity 19896
        polyatomic entity 19848
          molecule 19740
            organic molecule 19725
              organic cyclic compound 19517
                organic aromatic compound 19379
                  quinolines 2667
                    2,8-bis-Trifluoromethyl-4-quinoline carboxylic acid 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 19899
    subatomic particle 19897
      composite particle 19897
        hadron 19897
          baryon 19897
            nucleon 19897
              atomic nucleus 19897
                atom 19897
                  main group element atom 19836
                    p-block element atom 19836
                      carbon group element atom 19776
                        carbon atom 19772
                          organic molecular entity 19772
                            organic molecule 19725
                              organic cyclic compound 19517
                                organic heterocyclic compound 18894
                                  organonitrogen heterocyclic compound 18178
                                    quinolines 2667
                                      2,8-bis-Trifluoromethyl-4-quinoline carboxylic acid 9
paths to the root