Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:2,8-bis-Trifluoromethyl-4-quinoline carboxylic acid
go back to main search page
Accession:CHEBI:171694 term browser browse the term
Synonyms:exact_synonym: 2,8-bis(triluoromethyl)quinoline-4-carboxylic acid
 related_synonym: Formula=C12H5F6NO2;   InChI=1S/C12H5F6NO2/c13-11(14,15)7-3-1-2-5-6(10(20)21)4-8(12(16,17)18)19-9(5)7/h1-4H,(H,20,21);   InChIKey=QJTJIQBSZLFWFS-UHFFFAOYSA-N;   SMILES=FC(F)(F)C=1C=2N=C(C=C(C2C=CC1)C(O)=O)C(F)(F)F
 xref: CAS:35853-50-0;   Chemspider:148424;   HMDB:HMDB0060726
 xref_mesh: MESH:C057006


show annotations for term's descendants           Sort by:
2,8-bis-Trifluoromethyl-4-quinoline carboxylic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression ISO Ro 21-5104 results in increased expression of ABCB1 mRNA CTD PMID:25313206 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression
multiple interactions		 ISO Ro 21-5104 results in increased expression of CYP2B6 mRNA; Ro 21-5104 results in increased expression of CYP2B6 protein
NR1I2 mRNA promotes the reaction [Ro 21-5104 results in increased expression of CYP2B6 mRNA]		 CTD PMID:25313206 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases expression ISO Ro 21-5104 results in increased expression of CYP2C8 mRNA CTD PMID:25313206
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
increases expression		 ISO NR1I2 mRNA promotes the reaction [Ro 21-5104 results in increased expression of CYP3A4 mRNA]
Ro 21-5104 results in increased expression of CYP3A4 mRNA; Ro 21-5104 results in increased expression of CYP3A4 protein		 CTD PMID:25313206 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Ephx1 epoxide hydrolase 1 increases expression ISO Ro 21-5104 results in increased expression of EPHX1 mRNA CTD PMID:25313206 NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235 		JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO Ro 21-5104 promotes the reaction [NR1I2 protein binds to NCOA1 protein] CTD PMID:25313206 NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664 		JBrowse link
G Ncor2 nuclear receptor co-repressor 2 multiple interactions ISO Ro 21-5104 inhibits the reaction [NR1I2 protein binds to NCOR2 protein] CTD PMID:25313206 NCBI chr12:31,466,418...31,628,319
Ensembl chr12:31,466,412...31,628,319 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO NR1I2 mRNA promotes the reaction [Ro 21-5104 results in increased expression of CYP2B6 mRNA]; NR1I2 mRNA promotes the reaction [Ro 21-5104 results in increased expression of CYP3A4 mRNA]; Ro 21-5104 binds to and results in increased activity of NR1I2 protein; Ro 21-5104 inhibits the reaction [NR1I2 protein binds to NCOR2 protein]; Ro 21-5104 promotes the reaction [NR1I2 protein binds to NCOA1 protein] CTD PMID:25313206 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases expression ISO Ro 21-5104 results in increased expression of UGT1A3 mRNA CTD PMID:25313206 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19867
    chemical entity 19865
      molecular entity 19865
        polyatomic entity 19817
          molecule 19707
            organic molecule 19692
              organic cyclic compound 19482
                organic aromatic compound 19346
                  quinolines 2660
                    2,8-bis-Trifluoromethyl-4-quinoline carboxylic acid 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 19867
    subatomic particle 19865
      composite particle 19865
        hadron 19865
          baryon 19865
            nucleon 19865
              atomic nucleus 19865
                atom 19865
                  main group element atom 19803
                    p-block element atom 19803
                      carbon group element atom 19744
                        carbon atom 19740
                          organic molecular entity 19740
                            organic molecule 19692
                              organic cyclic compound 19482
                                organic heterocyclic compound 18872
                                  organonitrogen heterocyclic compound 18150
                                    quinolines 2660
                                      2,8-bis-Trifluoromethyl-4-quinoline carboxylic acid 9
paths to the root