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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:methylglyoxal
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Accession:CHEBI:17158 term browser browse the term
Definition:A 2-oxo aldehyde derived from propanal.
Synonyms:related_synonym: 1,2-propanedione;   2-Ketopropionaldehyde;   2-Oxopropanal;   2-oxopropionaldehyde;   CH3COCHO;   Formula=C3H4O2;   InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3;   InChIKey=AIJULSRZWUXGPQ-UHFFFAOYSA-N;   Pyruvaldehyde;   Pyruvic aldehyde;   SMILES=[H]C(=O)C(C)=O;   acetylformaldehyde;   acetylformyl;   alpha-ketopropionaldehyde
 alt_id: CHEBI:11643;   CHEBI:14599;   CHEBI:25303;   CHEBI:6875
 xref: Beilstein:906750;   CAS:78-98-8;   KEGG:C00546;   KNApSAcK:C00007562
 xref_mesh: MESH:D011765
 xref: PMID:10373458;   PMID:10723098;   PMID:11504881;   PMID:15520007;   PMID:17103372;   PMID:19202315;   PMID:20096340;   PMID:22983866;   PMID:23543734;   PMID:23845007;   PMID:24040205;   PMID:24168114;   PMID:26861824;   PMID:9506998;   Reaxys:906750;   Wikipedia:Methylglyoxal


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methylglyoxal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp5 acid phosphatase 5, tartrate resistant multiple interactions
increases expression		 ISO
EXP		 [TNFSF11 protein co-treated with Pyruvaldehyde] affects the activity of ACP5 protein; [TNFSF11 protein co-treated with Pyruvaldehyde] results in decreased activity of ACP5 protein; bergenin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in decreased activity of ACP5 protein]; MAPK8 protein affects the reaction [Pyruvaldehyde results in increased expression of ACP5 mRNA]
Pyruvaldehyde results in increased expression of ACP5 mRNA; Pyruvaldehyde results in increased expression of ACP5 protein		 CTD PMID:30217477 PMID:31103701 PMID:31369791 NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929 		JBrowse link
G Acta2 actin alpha 2, smooth muscle increases expression
multiple interactions		 ISO Pyruvaldehyde results in increased expression of ACTA2 protein
epigallocatechin gallate inhibits the reaction [Pyruvaldehyde results in increased expression of ACTA2 protein]		 CTD PMID:22101032 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Adgre1 adhesion G protein-coupled receptor E1 multiple interactions
increases expression		 ISO epigallocatechin gallate inhibits the reaction [Pyruvaldehyde results in increased expression of ADGRE1 protein] CTD PMID:22101032 NCBI chr 9:2,242,476...2,398,000
Ensembl chr 9:2,242,474...2,398,000 		JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions
increases expression
increases cleavage		 ISO bergenin inhibits the reaction [Pyruvaldehyde results in increased cleavage of AGER protein]; epigallocatechin gallate inhibits the reaction [Pyruvaldehyde results in increased expression of AGER protein]; honokiol affects the reaction [Pyruvaldehyde results in increased cleavage of AGER protein]; pimagedine inhibits the reaction [Pyruvaldehyde results in increased cleavage of AGER protein]
Pyruvaldehyde results in increased expression of AGER mRNA; Pyruvaldehyde results in increased expression of AGER protein		 CTD PMID:22101032 PMID:26723916 PMID:29148590 PMID:30447388 PMID:34656697 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078 		JBrowse link
G Agt angiotensinogen affects expression EXP Pyruvaldehyde affects the expression of AGT protein CTD PMID:24402234 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Aifm2 AIF family member 2 increases expression ISO Pyruvaldehyde results in increased expression of AIFM2 mRNA CTD PMID:30447388 NCBI chr20:29,654,283...29,679,239
Ensembl chr20:29,652,927...29,679,236 		JBrowse link
G Akr1a1 aldo-keto reductase family 1 member A1 increases reduction ISO
EXP		 AKR1A1 protein results in increased reduction of Pyruvaldehyde CTD PMID:10510318 PMID:29763686 NCBI chr 5:130,092,945...130,130,277
Ensembl chr 5:130,092,732...130,113,674 		JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B1 increases reduction ISO AKR1B1 protein results in increased reduction of Pyruvaldehyde CTD PMID:10510318 NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 increases expression ISO Pyruvaldehyde results in increased expression of AKR1C3 mRNA CTD PMID:25451587 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873 		JBrowse link
G Akr7a2 aldo-keto reductase family 7, member A2 decreases response to substance
increases expression		 ISO AKR7A5 protein results in decreased susceptibility to Pyruvaldehyde
AKR7A2 protein results in decreased susceptibility to Pyruvaldehyde
Pyruvaldehyde results in increased expression of AKR7A2 mRNA; Pyruvaldehyde results in increased expression of AKR7A2 protein		 CTD PMID:22001351 PMID:24590062 PMID:25451587 NCBI chr 5:151,552,375...151,560,914
Ensembl chr 5:151,552,343...151,560,909 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions		 ISO Pyruvaldehyde results in decreased phosphorylation of AKT1 protein
resveratrol inhibits the reaction [Pyruvaldehyde results in decreased phosphorylation of AKT1 protein]		 CTD PMID:22917016 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 multiple interactions ISO [TNFSF11 protein co-treated with Pyruvaldehyde] results in increased expression of AKT2 mRNA; bergenin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in increased expression of AKT2 mRNA] CTD PMID:31369791 NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817 		JBrowse link
G Alb albumin affects binding
multiple interactions
increases oxidation		 ISO Pyruvaldehyde binds to ALB protein
[ALB protein binds to Myristic Acid] promotes the reaction [Pyruvaldehyde results in increased oxidation of ALB protein]; [ALB protein binds to Oleic Acid] promotes the reaction [Pyruvaldehyde results in increased oxidation of ALB protein]; [ALB protein binds to Palmitic Acid] promotes the reaction [Pyruvaldehyde results in increased oxidation of ALB protein]; [ALB protein binds to stearic acid] promotes the reaction [Pyruvaldehyde results in increased oxidation of ALB protein]; [Pyruvaldehyde binds to ALB protein] which results in decreased metabolism of Prostaglandins; [Pyruvaldehyde results in increased oxidation of ALB protein] which results in decreased reduction of Dithionitrobenzoic Acid; Pyruvaldehyde inhibits the reaction [Warfarin binds to ALB protein]		 CTD PMID:20934417 PMID:25451573 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member multiple interactions EXP [Chloral Hydrate results in decreased activity of ALDH2 protein] which results in increased susceptibility to Pyruvaldehyde; [Disulfiram results in decreased activity of ALDH2 protein] which results in increased susceptibility to Pyruvaldehyde CTD PMID:21334317 NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521 		JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO Pyruvaldehyde results in increased expression of BAD mRNA CTD PMID:30447388 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression		 ISO
EXP		 naringenin inhibits the reaction [Pyruvaldehyde results in increased expression of BAX protein]; salvin inhibits the reaction [Pyruvaldehyde results in increased expression of BAX protein]
Phosphocreatine inhibits the reaction [Pyruvaldehyde results in increased expression of BAX protein]		 CTD PMID:26577515 PMID:31254498 PMID:34455488 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression		 ISO
EXP		 naringenin inhibits the reaction [Pyruvaldehyde results in decreased expression of BCL2 protein]; salvin inhibits the reaction [Pyruvaldehyde results in decreased expression of BCL2 protein]
Pyruvaldehyde results in decreased expression of BCL2 mRNA; Pyruvaldehyde results in decreased expression of BCL2 protein
Phosphocreatine inhibits the reaction [Pyruvaldehyde results in decreased expression of BCL2 protein]		 CTD PMID:26577515 PMID:30447388 PMID:31254498 PMID:34455488 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression
multiple interactions		 ISO Pyruvaldehyde results in increased expression of BDNF protein
sulforaphane promotes the reaction [Pyruvaldehyde results in increased expression of BDNF protein]		 CTD PMID:25933243 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Car2 carbonic anhydrase 2 multiple interactions ISO [TNFSF11 protein co-treated with Pyruvaldehyde] affects the expression of CAR2 mRNA CTD PMID:30217477 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818 		JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions
increases expression
increases activity
decreases expression		 ISO
EXP		 Pyruvaldehyde results in increased cleavage of CASP3 protein
naringenin inhibits the reaction [Pyruvaldehyde results in increased activity of CASP3 protein]; pimagedine inhibits the reaction [Pyruvaldehyde results in increased cleavage of CASP3 protein]; pterostilbene inhibits the reaction [Pyruvaldehyde results in increased cleavage of CASP3 protein]; salvin inhibits the reaction [Pyruvaldehyde results in increased expression of CASP3 protein]; sulforaphane inhibits the reaction [Pyruvaldehyde results in increased activity of CASP3 protein]; Telmisartan inhibits the reaction [Pyruvaldehyde results in increased cleavage of CASP3 protein]
Pyruvaldehyde results in increased expression of CASP3 protein modified form
resveratrol inhibits the reaction [Pyruvaldehyde results in increased activity of CASP3 protein]
Phosphocreatine inhibits the reaction [Pyruvaldehyde results in decreased expression of CASP3 protein]; Phosphocreatine inhibits the reaction [Pyruvaldehyde results in increased expression of CASP3 protein modified form]		 CTD PMID:18565324 PMID:20621070 PMID:21793156 PMID:25933243 PMID:26577515 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 multiple interactions
increases cleavage		 ISO pimagedine inhibits the reaction [Pyruvaldehyde results in increased cleavage of CASP7 protein]; pterostilbene inhibits the reaction [Pyruvaldehyde results in increased cleavage of CASP7 protein] CTD PMID:33930484 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases expression
increases activity
increases cleavage
decreases expression		 ISO
EXP		 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin inhibits the reaction [Pyruvaldehyde results in increased expression of CASP9 protein]]; naringenin inhibits the reaction [Pyruvaldehyde results in increased activity of CASP9 protein]; pimagedine inhibits the reaction [Pyruvaldehyde results in increased cleavage of CASP9 protein]; pterostilbene inhibits the reaction [Pyruvaldehyde results in increased cleavage of CASP9 protein]; salvin inhibits the reaction [Pyruvaldehyde results in increased expression of CASP9 protein]
Pyruvaldehyde results in decreased expression of CASP9 protein
Phosphocreatine inhibits the reaction [Pyruvaldehyde results in decreased expression of CASP9 protein]		 CTD PMID:26577515 PMID:31254498 PMID:33930484 PMID:34455488 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase increases activity ISO Pyruvaldehyde results in increased activity of CAT protein CTD PMID:34656697 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases expression		 ISO epigallocatechin gallate inhibits the reaction [Pyruvaldehyde results in increased expression of CCL2 protein] CTD PMID:22101032 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Clcn7 chloride voltage-gated channel 7 multiple interactions ISO [TNFSF11 protein co-treated with Pyruvaldehyde] affects the expression of CLCN7 mRNA CTD PMID:30217477 NCBI chr10:14,151,758...14,177,130
Ensembl chr10:14,151,758...14,177,130 		JBrowse link
G Col3a1 collagen type III alpha 1 chain increases expression
multiple interactions		 ISO Pyruvaldehyde results in increased expression of COL3A1 protein
epigallocatechin gallate inhibits the reaction [Pyruvaldehyde results in increased expression of COL3A1 protein]		 CTD PMID:22101032 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547 		JBrowse link
G Cp ceruloplasmin multiple interactions
decreases activity		 ISO bathocuproine inhibits the reaction [Pyruvaldehyde promotes the reaction [CP protein binds to CP protein]]; Ditiocarb inhibits the reaction [Pyruvaldehyde promotes the reaction [CP protein binds to CP protein]]; formic acid inhibits the reaction [Pyruvaldehyde promotes the reaction [CP protein binds to CP protein]]; Pyruvaldehyde promotes the reaction [CP protein binds to CP protein]; Sodium Azide inhibits the reaction [Pyruvaldehyde promotes the reaction [CP protein binds to CP protein]]
Pyruvaldehyde results in decreased activity of CP protein		 CTD PMID:16756764 NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075 		JBrowse link
G Ctsk cathepsin K increases expression
multiple interactions		 EXP
ISO		 Pyruvaldehyde results in increased expression of CTSK mRNA
MAPK8 protein affects the reaction [Pyruvaldehyde results in increased expression of CTSK mRNA]		 CTD PMID:31103701 NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550 		JBrowse link
G Ctss cathepsin S decreases activity ISO Pyruvaldehyde results in decreased activity of CTSS protein CTD PMID:16671891 NCBI chr 2:183,086,437...183,114,483
Ensembl chr 2:183,086,437...183,114,483 		JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions
increases expression		 ISO Liraglutide inhibits the reaction [Pyruvaldehyde results in increased expression of CYBA mRNA] CTD PMID:35985417 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721 		JBrowse link
G Cybb cytochrome b-245 beta chain increases expression
multiple interactions		 ISO Pyruvaldehyde results in increased expression of CYBB mRNA
Liraglutide inhibits the reaction [Pyruvaldehyde results in increased expression of CYBB mRNA]		 CTD PMID:35985417 NCBI chr  X:13,358,101...13,392,570
Ensembl chr  X:13,359,430...13,392,586 		JBrowse link
G Cycs cytochrome c, somatic increases expression
multiple interactions		 EXP Pyruvaldehyde results in increased expression of CYCS protein
Phosphocreatine inhibits the reaction [Pyruvaldehyde results in increased expression of CYCS protein]		 CTD PMID:34455488 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [CYP1A2 protein results in increased metabolism of and results in increased susceptibility to Meloxicam] which results in increased chemical synthesis of Pyruvaldehyde CTD PMID:33253783 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Eno2 enolase 2 decreases expression ISO Pyruvaldehyde results in decreased expression of ENO2 protein CTD PMID:37431083 NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980 		JBrowse link
G Fn1 fibronectin 1 multiple interactions
increases expression		 EXP diphenyleneiodonium inhibits the reaction [Pyruvaldehyde results in increased expression of FN1 mRNA]; manumycin inhibits the reaction [Pyruvaldehyde results in increased expression of FN1 mRNA]; SB 203580 inhibits the reaction [Pyruvaldehyde results in increased expression of FN1 mRNA] CTD PMID:17635749 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [TNFSF11 protein co-treated with Pyruvaldehyde] affects the expression of FOS mRNA CTD PMID:30217477 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gab2 GRB2-associated binding protein 2 multiple interactions ISO [TNFSF11 protein co-treated with Pyruvaldehyde] affects the expression of GAB2 mRNA CTD PMID:30217477 NCBI chr 1:151,429,844...151,625,708
Ensembl chr 1:151,429,695...151,625,031 		JBrowse link
G Glo1 glyoxalase 1 affects response to substance
multiple interactions
decreases expression
decreases activity
affects expression
increases expression		 ISO
EXP		 GLO1 protein affects the susceptibility to Pyruvaldehyde
GLO1 protein affects the reaction [Pyruvaldehyde binds to HSPB1 protein]; NFE2L2 protein affects the reaction [Resveratrol affects the reaction [Pyruvaldehyde affects the expression of GLO1 protein]]; pimagedine inhibits the reaction [Pyruvaldehyde results in decreased expression of GLO1 protein]; pterostilbene inhibits the reaction [Pyruvaldehyde results in decreased expression of GLO1 protein]; Resveratrol affects the reaction [Pyruvaldehyde affects the expression of GLO1 protein]; Rosiglitazone affects the reaction [Pyruvaldehyde affects the expression of GLO1 protein]; sulforaphane inhibits the reaction [Pyruvaldehyde results in decreased expression of GLO1 protein]
[TNFSF11 protein co-treated with Pyruvaldehyde] affects the expression of GLO1 protein; [TNFSF11 protein co-treated with Pyruvaldehyde] results in decreased activity of GLO1 protein; [TNFSF11 protein co-treated with Pyruvaldehyde] results in decreased expression of GLO1 protein; acetovanillone inhibits the reaction [Pyruvaldehyde results in decreased activity of GLO1 protein]; bergenin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in decreased expression of GLO1 protein]; bergenin inhibits the reaction [Pyruvaldehyde results in decreased activity of GLO1 protein]; crocin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in decreased activity of GLO1 protein]; honokiol inhibits the reaction [Pyruvaldehyde results in decreased activity of GLO1 protein]; Limonene inhibits the reaction [Pyruvaldehyde results in decreased activity of GLO1 protein]; pimagedine inhibits the reaction [Pyruvaldehyde results in decreased activity of GLO1 protein]
magnolol inhibits the reaction [Pyruvaldehyde results in decreased activity of GLO1 protein]; pimagedine inhibits the reaction [Pyruvaldehyde results in decreased activity of GLO1 protein]
Pyruvaldehyde results in increased expression of GLO1 mRNA		 CTD PMID:20093988 PMID:22917016 PMID:25042521 PMID:25933243 PMID:26723916 More... NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649 		JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions
increases expression		 EXP magnolol promotes the reaction [Pyruvaldehyde results in increased expression of GPX1 mRNA]; pimagedine inhibits the reaction [Pyruvaldehyde results in increased expression of GPX1 mRNA] CTD PMID:28919305 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases phosphorylation
multiple interactions		 EXP Pyruvaldehyde results in decreased phosphorylation of GSK3B protein
Phosphocreatine inhibits the reaction [Pyruvaldehyde results in decreased phosphorylation of GSK3B protein]		 CTD PMID:34455488 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Gsr glutathione-disulfide reductase decreases activity EXP Pyruvaldehyde results in decreased activity of GSR protein CTD PMID:24831520 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Gsta5 glutathione S-transferase alpha 5 increases response to substance EXP GSTA5 protein results in increased susceptibility to Pyruvaldehyde CTD PMID:12076520 NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472 		JBrowse link
G Hagh hydroxyacyl glutathione hydrolase increases expression ISO Pyruvaldehyde results in increased expression of GLO2 protein CTD PMID:37431083 NCBI chr10:13,874,883...13,889,527
Ensembl chr10:13,875,241...13,889,504 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO [Glucose co-treated with Oxygen deficiency] promotes the reaction [Pyruvaldehyde binds to and results in decreased activity of HIF1A protein]; Pyruvaldehyde binds to and results in decreased activity of HIF1A protein CTD PMID:18227068 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
affects expression
decreases expression		 ISO Acetylcysteine affects the reaction [Pyruvaldehyde affects the expression of HMOX1 protein]; NFE2L2 protein affects the reaction [Resveratrol affects the reaction [Pyruvaldehyde affects the expression of HMOX1 protein]]; pimagedine inhibits the reaction [Pyruvaldehyde results in decreased expression of HMOX1 mRNA]; pimagedine inhibits the reaction [Pyruvaldehyde results in decreased expression of HMOX1 protein]; pterostilbene inhibits the reaction [Pyruvaldehyde results in decreased expression of HMOX1 mRNA]; pterostilbene inhibits the reaction [Pyruvaldehyde results in decreased expression of HMOX1 protein]; Resveratrol affects the reaction [Pyruvaldehyde affects the expression of HMOX1 protein]; Rosiglitazone affects the reaction [Pyruvaldehyde affects the expression of HMOX1 protein]
bergenin inhibits the reaction [Pyruvaldehyde results in decreased expression of HMOX1 protein]; Limonene inhibits the reaction [Pyruvaldehyde results in decreased expression of HMOX1 protein]; pimagedine inhibits the reaction [Pyruvaldehyde results in decreased expression of HMOX1 protein]
Pyruvaldehyde results in decreased expression of HMOX1 mRNA; Pyruvaldehyde results in decreased expression of HMOX1 protein		 CTD PMID:22917016 PMID:28986142 PMID:29148590 PMID:33930484 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hras HRas proto-oncogene, GTPase increases activity EXP Pyruvaldehyde results in increased activity of HRAS protein CTD PMID:17635749 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615 		JBrowse link
G Hspb1 heat shock protein family B (small) member 1 affects binding
multiple interactions		 ISO Pyruvaldehyde binds to HSPB1 protein
GLO1 protein affects the reaction [Pyruvaldehyde binds to HSPB1 protein]		 CTD PMID:20093988 NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
decreases expression		 EXP
ISO		 magnolol inhibits the reaction [Pyruvaldehyde results in decreased expression of IL1B protein]; monascin inhibits the reaction [Pyruvaldehyde results in increased expression of IL1B protein]; pimagedine inhibits the reaction [Pyruvaldehyde results in decreased expression of IL1B protein]; PPARG mutant form inhibits the reaction [monascin inhibits the reaction [Pyruvaldehyde results in increased expression of IL1B protein]]; PPARG mutant form inhibits the reaction [Rosiglitazone inhibits the reaction [Pyruvaldehyde results in increased expression of IL1B protein]]; Rosiglitazone inhibits the reaction [Pyruvaldehyde results in increased expression of IL1B protein]
Pyruvaldehyde results in increased expression of IL1B mRNA; Pyruvaldehyde results in increased expression of IL1B protein		 CTD PMID:23954466 PMID:28919305 PMID:31103701 PMID:34656697 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 affects expression
multiple interactions
increases expression
increases secretion		 ISO
EXP		 Pyruvaldehyde analog affects the expression of IL6 mRNA
acetovanillone inhibits the reaction [Pyruvaldehyde results in increased expression of IL6 protein]; bergenin inhibits the reaction [Pyruvaldehyde results in increased expression of IL6 protein]; honokiol affects the reaction [Pyruvaldehyde results in increased expression of IL6 protein]; Limonene inhibits the reaction [Pyruvaldehyde results in increased secretion of IL6 protein]; pimagedine inhibits the reaction [Pyruvaldehyde results in increased expression of IL6 protein]
Pyruvaldehyde results in increased expression of IL6 mRNA; Pyruvaldehyde results in increased expression of IL6 protein		 CTD PMID:20200221 PMID:25042521 PMID:26723916 PMID:28986142 PMID:29148590 More... NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ins1 insulin 1 multiple interactions
decreases secretion		 EXP Phosphocreatine inhibits the reaction [Pyruvaldehyde results in decreased secretion of INS1 protein]; Pyruvaldehyde results in decreased secretion of and results in decreased expression of INS1 protein CTD PMID:23954466 PMID:34455488 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Ins2 insulin 2 multiple interactions
decreases expression		 EXP magnolol inhibits the reaction [Pyruvaldehyde results in decreased expression of INS2 mRNA] CTD PMID:28919305 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Insr insulin receptor multiple interactions
decreases phosphorylation		 ISO Acetylcysteine inhibits the reaction [Pyruvaldehyde results in decreased phosphorylation of INSR protein]; resveratrol inhibits the reaction [Pyruvaldehyde results in decreased phosphorylation of INSR protein]; rosiglitazone inhibits the reaction [Pyruvaldehyde results in decreased phosphorylation of INSR protein] CTD PMID:22917016 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883 		JBrowse link
G Irs1 insulin receptor substrate 1 decreases phosphorylation
multiple interactions		 EXP Pyruvaldehyde results in decreased phosphorylation of IRS1 protein
Phosphocreatine inhibits the reaction [Pyruvaldehyde results in decreased phosphorylation of IRS1 protein]		 CTD PMID:23954466 PMID:34455488 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122 		JBrowse link
G Map2 microtubule-associated protein 2 decreases expression ISO Pyruvaldehyde results in decreased expression of MAP2 protein CTD PMID:37431083 NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions		 ISO Pyruvaldehyde results in increased phosphorylation of MAPK1 protein
sulforaphane inhibits the reaction [Pyruvaldehyde results in increased phosphorylation of MAPK1 protein]		 CTD PMID:25933243 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO sulforaphane inhibits the reaction [Pyruvaldehyde results in increased phosphorylation of MAPK3 protein]
[TNFSF11 protein co-treated with Pyruvaldehyde] affects the expression of MAPK3 mRNA; [TNFSF11 protein co-treated with Pyruvaldehyde] results in increased expression of MAPK3 mRNA; bergenin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in increased expression of MAPK3 mRNA]		 CTD PMID:25933243 PMID:30217477 PMID:31369791 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions		 ISO Pyruvaldehyde results in increased phosphorylation of MAPK8 protein
sulforaphane inhibits the reaction [Pyruvaldehyde results in increased phosphorylation of MAPK8 protein]
MAPK8 protein affects the reaction [Pyruvaldehyde results in increased expression of ACP5 mRNA]; MAPK8 protein affects the reaction [Pyruvaldehyde results in increased expression of CTSK mRNA]; MAPK8 protein affects the reaction [Pyruvaldehyde results in increased expression of OSCAR mRNA]		 CTD PMID:25933243 PMID:31103701 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation
multiple interactions		 ISO Pyruvaldehyde results in increased phosphorylation of MAPK9 protein
sulforaphane inhibits the reaction [Pyruvaldehyde results in increased phosphorylation of MAPK9 protein]		 CTD PMID:25933243 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO Pyruvaldehyde promotes the reaction [MAPT protein binds to MAPT protein] CTD PMID:17082178 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129 		JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression
multiple interactions		 ISO Pyruvaldehyde results in increased expression of MMP9 protein
[TNFSF11 protein co-treated with Pyruvaldehyde co-treated with bergenin] results in decreased expression of MMP9 mRNA		 CTD PMID:28760545 PMID:31369791 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 multiple interactions ISO [TNFSF11 protein co-treated with Pyruvaldehyde] affects the expression of NFATC1 mRNA CTD PMID:30217477 NCBI chr18:74,046,422...74,156,041
Ensembl chr18:74,046,904...74,156,028 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
affects localization
decreases phosphorylation
affects response to substance
decreases expression
affects expression		 ISO
EXP		 [Resveratrol results in increased activity of NFE2L2 protein] which results in decreased susceptibility to Pyruvaldehyde; NFE2L2 protein affects the reaction [Resveratrol affects the reaction [Pyruvaldehyde affects the expression of GLO1 protein]]; NFE2L2 protein affects the reaction [Resveratrol affects the reaction [Pyruvaldehyde affects the expression of HMOX1 protein]]; NFE2L2 protein affects the reaction [Resveratrol inhibits the reaction [Pyruvaldehyde affects the localization of SLC2A2 protein]]; NFE2L2 protein affects the reaction [Resveratrol inhibits the reaction [Pyruvaldehyde results in decreased uptake of 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose]]; NFE2L2 protein affects the reaction [Resveratrol inhibits the reaction [Pyruvaldehyde results in increased expression of PTPN1 protein]]; pimagedine inhibits the reaction [Pyruvaldehyde affects the localization of NFE2L2 protein]; pterostilbene inhibits the reaction [Pyruvaldehyde affects the localization of NFE2L2 protein]; Resveratrol inhibits the reaction [Pyruvaldehyde results in decreased phosphorylation of NFE2L2 protein]
NFE2L2 protein affects the susceptibility to Pyruvaldehyde
Pyruvaldehyde results in decreased expression of NFE2L2 mRNA
Pyruvaldehyde affects the expression of NFE2L2 protein
bergenin affects the reaction [Pyruvaldehyde affects the expression of NFE2L2 protein]		 CTD PMID:22917016 PMID:23331247 PMID:23954466 PMID:25451587 PMID:28263721 More... NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nos2 nitric oxide synthase 2 affects response to substance
increases expression
multiple interactions		 EXP NOS2 protein affects the susceptibility to Pyruvaldehyde
Pyruvaldehyde results in increased expression of NOS2 protein
pyrrolidine dithiocarbamic acid inhibits the reaction [Pyruvaldehyde results in increased expression of NOS2 protein]		 CTD PMID:20621070 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO Pyruvaldehyde results in increased expression of NQO1 mRNA CTD PMID:25451587 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nrf1 nuclear respiratory factor 1 multiple interactions
increases expression		 EXP monascin inhibits the reaction [Pyruvaldehyde results in increased expression of NRF1 mRNA]; Silymarin inhibits the reaction [Pyruvaldehyde results in increased expression of NRF1 mRNA]; Tretinoin inhibits the reaction [monascin inhibits the reaction [Pyruvaldehyde results in increased expression of NRF1 mRNA]] CTD PMID:23331247 NCBI chr 4:58,664,932...58,772,328
Ensembl chr 4:58,664,957...58,825,328 		JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 decreases expression
multiple interactions		 ISO Pyruvaldehyde results in decreased expression of NTRK2 protein
sulforaphane inhibits the reaction [Pyruvaldehyde results in decreased expression of NTRK2 protein]		 CTD PMID:25933243 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136 		JBrowse link
G Oscar osteoclast associated Ig-like receptor increases expression
multiple interactions		 ISO
EXP		 Pyruvaldehyde results in increased expression of OSCAR mRNA
MAPK8 protein affects the reaction [Pyruvaldehyde results in increased expression of OSCAR mRNA]		 CTD PMID:31103701 NCBI chr 1:65,607,214...65,615,395
Ensembl chr 1:65,607,410...65,613,758 		JBrowse link
G Ostm1 osteoclastogenesis associated transmembrane protein 1 multiple interactions ISO [TNFSF11 protein co-treated with Pyruvaldehyde] affects the expression of OSTM1 mRNA; [TNFSF11 protein co-treated with Pyruvaldehyde] results in increased expression of OSTM1 mRNA; bergenin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in increased expression of OSTM1 mRNA] CTD PMID:30217477 PMID:31369791 NCBI chr20:46,071,657...46,187,049
Ensembl chr20:46,153,075...46,187,023 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage		 ISO naringenin inhibits the reaction [Pyruvaldehyde results in increased cleavage of PARP1 protein]; pimagedine inhibits the reaction [Pyruvaldehyde results in increased cleavage of PARP1 protein]; pterostilbene inhibits the reaction [Pyruvaldehyde results in increased cleavage of PARP1 protein] CTD PMID:31254498 PMID:33930484 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 multiple interactions EXP [magnolol co-treated with Pyruvaldehyde] results in increased expression of PDX1 mRNA CTD PMID:28919305 NCBI chr12:7,757,865...7,763,064
Ensembl chr12:7,757,865...7,763,064 		JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 multiple interactions
increases expression		 ISO epigallocatechin gallate inhibits the reaction [Pyruvaldehyde results in increased expression of PECAM1 protein] CTD PMID:22101032 NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116 		JBrowse link
G Pon1 paraoxonase 1 multiple interactions
decreases activity		 ISO Pyruvaldehyde inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon]; Pyruvaldehyde inhibits the reaction [PON1 protein results in increased hydrolysis of phenylacetic acid]
Pyruvaldehyde results in decreased activity of PON1 protein		 CTD PMID:15375178 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions EXP PPARG mutant form inhibits the reaction [monascin inhibits the reaction [Pyruvaldehyde results in decreased uptake of 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose]]; PPARG mutant form inhibits the reaction [monascin inhibits the reaction [Pyruvaldehyde results in increased expression of IL1B protein]]; PPARG mutant form inhibits the reaction [monascin inhibits the reaction [Pyruvaldehyde results in increased expression of TNF protein]]; PPARG mutant form inhibits the reaction [Rosiglitazone inhibits the reaction [Pyruvaldehyde results in decreased uptake of 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose]]; PPARG mutant form inhibits the reaction [Rosiglitazone inhibits the reaction [Pyruvaldehyde results in increased expression of IL1B protein]]; PPARG mutant form inhibits the reaction [Rosiglitazone inhibits the reaction [Pyruvaldehyde results in increased expression of TNF protein]] CTD PMID:23954466 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO
EXP		 [Limonene co-treated with Pyruvaldehyde] results in increased expression of PPARGC1A protein; [Pyruvaldehyde co-treated with honokiol] results in increased expression of PPARGC1A protein; [Pyruvaldehyde co-treated with pimagedine] results in increased expression of PPARGC1A protein
[magnolol co-treated with Pyruvaldehyde] results in increased expression of PPARGC1A protein; [pimagedine co-treated with Pyruvaldehyde] results in increased expression of PPARGC1A protein		 CTD PMID:26723916 PMID:28919305 PMID:28986142 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Ppid peptidylprolyl isomerase D increases expression
multiple interactions		 EXP Pyruvaldehyde results in increased expression of PPID protein
Phosphocreatine inhibits the reaction [Pyruvaldehyde results in increased expression of PPID protein]		 CTD PMID:34455488 NCBI chr 2:164,727,803...164,740,168
Ensembl chr 2:164,727,779...164,740,221 		JBrowse link
G Psen1 presenilin 1 increases expression ISO Pyruvaldehyde results in increased expression of PSEN1 mRNA; Pyruvaldehyde results in increased expression of PSEN1 protein CTD PMID:34656697 NCBI chr 6:103,323,052...103,375,088
Ensembl chr 6:103,323,120...103,371,650 		JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [Pyruvaldehyde results in increased expression of PTPN1 protein]; NFE2L2 protein affects the reaction [resveratrol inhibits the reaction [Pyruvaldehyde results in increased expression of PTPN1 protein]]; rosiglitazone inhibits the reaction [Pyruvaldehyde results in increased expression of PTPN1 protein] CTD PMID:22917016 NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases activity
affects localization		 EXP pyrrolidine dithiocarbamic acid inhibits the reaction [Pyruvaldehyde affects the localization of RELA protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [Pyruvaldehyde results in increased activity of RELA protein] CTD PMID:20621070 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions EXP [magnolol co-treated with Pyruvaldehyde] results in increased expression of SIRT1 protein; [pimagedine co-treated with Pyruvaldehyde] results in increased expression of SIRT1 protein CTD PMID:28919305 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Slc2a2 solute carrier family 2 member 2 multiple interactions
affects localization		 ISO Acetylcysteine inhibits the reaction [Pyruvaldehyde affects the localization of SLC2A2 protein]; NFE2L2 protein affects the reaction [resveratrol inhibits the reaction [Pyruvaldehyde affects the localization of SLC2A2 protein]]; resveratrol inhibits the reaction [Pyruvaldehyde affects the localization of SLC2A2 protein]; rosiglitazone inhibits the reaction [Pyruvaldehyde affects the localization of SLC2A2 protein] CTD PMID:22917016 NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933 		JBrowse link
G Sod1 superoxide dismutase 1 decreases expression
multiple interactions		 ISO Pyruvaldehyde results in decreased expression of SOD1 mRNA
pimagedine inhibits the reaction [Pyruvaldehyde results in decreased expression of SOD1 mRNA]; pterostilbene inhibits the reaction [Pyruvaldehyde results in decreased expression of SOD1 mRNA]		 CTD PMID:30447388 PMID:33930484 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 decreases expression
increases expression		 ISO Pyruvaldehyde results in decreased expression of SOD2 mRNA
Pyruvaldehyde results in increased expression of SOD2 mRNA		 CTD PMID:30447388 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
increases phosphorylation		 EXP Phosphocreatine inhibits the reaction [Pyruvaldehyde results in increased phosphorylation of STAT3 protein] CTD PMID:34455488 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tcirg1 T-cell immune regulator 1, ATPase H+ transporting V0 subunit A3 multiple interactions ISO [TNFSF11 protein co-treated with Pyruvaldehyde] affects the expression of TCIRG1 mRNA CTD PMID:30217477 NCBI chr 1:201,127,034...201,138,787
Ensembl chr 1:201,127,034...201,138,742 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
increases expression		 EXP
ISO		 diphenyleneiodonium inhibits the reaction [Pyruvaldehyde results in increased expression of TGFB1 mRNA]; diphenyleneiodonium inhibits the reaction [Pyruvaldehyde results in increased expression of TGFB1 protein]
Pyruvaldehyde results in increased expression of TGFB1 mRNA; Pyruvaldehyde results in increased expression of TGFB1 protein
epigallocatechin gallate inhibits the reaction [Pyruvaldehyde results in increased expression of TGFB1 protein]		 CTD PMID:17635749 PMID:22101032 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
increases secretion		 EXP
ISO		 monascin inhibits the reaction [Pyruvaldehyde results in increased expression of TNF protein]; PPARG mutant form inhibits the reaction [monascin inhibits the reaction [Pyruvaldehyde results in increased expression of TNF protein]]; PPARG mutant form inhibits the reaction [rosiglitazone inhibits the reaction [Pyruvaldehyde results in increased expression of TNF protein]]; rosiglitazone inhibits the reaction [Pyruvaldehyde results in increased expression of TNF protein]
acetovanillone inhibits the reaction [Pyruvaldehyde results in increased expression of TNF protein]; honokiol inhibits the reaction [Pyruvaldehyde results in increased expression of TNF protein]; limonene inhibits the reaction [Pyruvaldehyde results in increased secretion of TNF protein]; pimagedine inhibits the reaction [Pyruvaldehyde results in increased expression of TNF protein]		 CTD PMID:23954466 PMID:25042521 PMID:26723916 PMID:28986142 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO [TNFSF11 protein co-treated with Pyruvaldehyde co-treated with bergenin] results in decreased expression of MMP9 mRNA; [TNFSF11 protein co-treated with Pyruvaldehyde] affects the activity of ACP5 protein; [TNFSF11 protein co-treated with Pyruvaldehyde] affects the expression of CAR2 mRNA; [TNFSF11 protein co-treated with Pyruvaldehyde] affects the expression of CLCN7 mRNA; [TNFSF11 protein co-treated with Pyruvaldehyde] affects the expression of FOS mRNA; [TNFSF11 protein co-treated with Pyruvaldehyde] affects the expression of GAB2 mRNA; [TNFSF11 protein co-treated with Pyruvaldehyde] affects the expression of GLO1 protein; [TNFSF11 protein co-treated with Pyruvaldehyde] affects the expression of MAPK3 mRNA; [TNFSF11 protein co-treated with Pyruvaldehyde] affects the expression of NFATC1 mRNA; [TNFSF11 protein co-treated with Pyruvaldehyde] affects the expression of OSTM1 mRNA; [TNFSF11 protein co-treated with Pyruvaldehyde] affects the expression of TCIRG1 mRNA; [TNFSF11 protein co-treated with Pyruvaldehyde] affects the expression of TRAF6 mRNA; [TNFSF11 protein co-treated with Pyruvaldehyde] results in decreased activity of ACP5 protein; [TNFSF11 protein co-treated with Pyruvaldehyde] results in decreased activity of GLO1 protein; [TNFSF11 protein co-treated with Pyruvaldehyde] results in decreased expression of GLO1 protein; [TNFSF11 protein co-treated with Pyruvaldehyde] results in increased expression of AKT2 mRNA; [TNFSF11 protein co-treated with Pyruvaldehyde] results in increased expression of MAPK3 mRNA; [TNFSF11 protein co-treated with Pyruvaldehyde] results in increased expression of OSTM1 mRNA; bergenin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in decreased activity of ACP5 protein]; bergenin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in decreased expression of GLO1 protein]; bergenin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in increased expression of AKT2 mRNA]; bergenin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in increased expression of MAPK3 mRNA]; bergenin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in increased expression of OSTM1 mRNA]; crocin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in decreased activity of GLO1 protein] CTD PMID:30217477 PMID:30580027 PMID:31369791 NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445 		JBrowse link
G Traf6 TNF receptor associated factor 6 multiple interactions ISO [TNFSF11 protein co-treated with Pyruvaldehyde] affects the expression of TRAF6 mRNA CTD PMID:30217477 NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507 		JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 multiple interactions
increases activity		 ISO [Pyruvaldehyde results in increased activity of TRPA1 protein] which results in increased transport of Calcium CTD PMID:22863862 NCBI chr 5:4,379,862...4,434,133
Ensembl chr 5:4,379,999...4,433,570 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions
increases expression		 EXP Silymarin inhibits the reaction [Pyruvaldehyde results in increased expression of VCAM1 mRNA] CTD PMID:23331247 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
increases expression		 ISO epigallocatechin gallate inhibits the reaction [Pyruvaldehyde results in increased expression of VEGFA protein] CTD PMID:22101032 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Xdh xanthine dehydrogenase increases expression
multiple interactions		 ISO Pyruvaldehyde results in increased expression of XDH mRNA
Liraglutide inhibits the reaction [Pyruvaldehyde results in increased expression of XDH mRNA]		 CTD PMID:35985417 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19922
    role 19894
      application 19735
        solvent 17245
          formic acid 9051
            formyl group 9008
              aldehyde 9008
                propanals 1818
                  methylglyoxal 92
                    mitoguazone 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19922
    subatomic particle 19892
      composite particle 19892
        hadron 19920
          baryon 19892
            nucleon 19920
              atomic nucleus 19892
                atom 19892
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19805
                        carbon atom 19802
                          organic molecular entity 19775
                            heteroorganic entity 19556
                              organochalcogen compound 19315
                                organooxygen compound 19205
                                  carbon oxoacid 18694
                                    carboxylic acid 18691
                                      carboacyl group 17723
                                        univalent carboacyl group 17723
                                          formyl group 9008
                                            aldehyde 9008
                                              ketoaldehyde 92
                                                2-oxo aldehyde 92
                                                  methylglyoxal 92
                                                    mitoguazone 0
paths to the root