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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:xylitol
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Accession:CHEBI:17151 term browser browse the term
Definition:A pentitol (five-carbon sugar alcohol) having meso-configuration, being derived from xylose by reduction of the carbonyl group.
Synonyms:exact_synonym: (2R,3r,4S)-pentane-1,2,3,4,5-pentol
 related_synonym: (2R,3R,4S)-Pentane-1,2,3,4,5-pentaol;   D-XYLITOL;   Formula=C5H12O5;   InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+;   InChIKey=HEBKCHPVOIAQTA-SCDXWVJYSA-N;   L-xylitol;   Meso-xylitol;   SMILES=OC[C@H](O)[C@@H](O)[C@H](O)CO;   Xylit;   xylite
 alt_id: CHEBI:10078;   CHEBI:15328;   CHEBI:253147;   CHEBI:27339;   CHEBI:46522;   CHEBI:60939
 xref: CAS:87-99-0;   DrugBank:DB01904;   Drug_Central:4604;   Gmelin:82893;   HMDB:HMDB0002917;   KEGG:C00379;   KEGG:D00061
 xref_mesh: MESH:D014993
 xref: MetaCyc:XYLITOL;   PDBeChem:XYL;   PMID:11154411;   PMID:11163479;   PMID:12061879;   PMID:15377394;   PMID:16708791;   PMID:16901854;   PMID:17216457;   PMID:17216458;   PMID:17336832;   PMID:17979222;   PMID:18316079;   PMID:20030329;   PMID:22735334;   PMID:22791282;   PMID:23247825;   PMID:23287496;   PMID:23338824;   PMID:23589387;   PMID:23597921;   PMID:23615861;   PMID:23796483;   PMID:23916161;   PMID:23957303;   PMID:24012734;   PMID:24643482;   PMID:25108762;   Reaxys:1720523;   Wikipedia:Xylitol


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xylitol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl2 ABL proto-oncogene 2, non-receptor tyrosine kinase increases expression ISO Xylitol results in increased expression of ABL2 mRNA CTD PMID:32275922 NCBI chr13:71,223,902...71,319,770
Ensembl chr13:71,224,019...71,389,775 		JBrowse link
G Arhgef2 Rho/Rac guanine nucleotide exchange factor 2 increases expression ISO Xylitol results in increased expression of ARHGEF2 mRNA CTD PMID:32275922 NCBI chr 2:176,358,909...176,416,178
Ensembl chr 2:176,358,904...176,417,646 		JBrowse link
G Ash1l ASH1 like histone lysine methyltransferase increases expression ISO Xylitol results in increased expression of ASH1L mRNA CTD PMID:32275922 NCBI chr 2:176,644,393...176,780,848
Ensembl chr 2:176,644,924...176,780,847 		JBrowse link
G Atf4 activating transcription factor 4 increases expression ISO Xylitol results in increased expression of ATF4 protein CTD PMID:32275922 NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:113,684,681...113,686,739 		JBrowse link
G Bcap29 B-cell receptor-associated protein 29 decreases expression ISO Xylitol results in decreased expression of BCAP29 mRNA CTD PMID:32275922 NCBI chr 6:53,910,209...53,950,206
Ensembl chr 6:53,910,216...53,949,963 		JBrowse link
G Birc6 baculoviral IAP repeat-containing 6 increases expression ISO Xylitol results in increased expression of BIRC6 mRNA CTD PMID:32275922 NCBI chr 6:26,474,843...26,668,275
Ensembl chr 6:26,474,843...26,668,507 		JBrowse link
G Casp3 caspase 3 increases expression ISO Xylitol results in increased expression of CASP3 protein modified form CTD PMID:32275922 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Cep250 centrosomal protein 250 increases expression ISO Xylitol results in increased expression of CEP250 mRNA CTD PMID:32275922 NCBI chr 3:164,931,033...164,976,210
Ensembl chr 3:164,931,066...164,976,210 		JBrowse link
G Chac1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 multiple interactions
increases expression 		ISO ursodoxicoltaurine inhibits the reaction [Xylitol results in increased expression of CHAC1 protein]
Xylitol results in increased expression of CHAC1 mRNA; Xylitol results in increased expression of CHAC1 protein 		CTD PMID:32275922 NCBI chr 3:126,796,131...126,799,352
Ensembl chr 3:126,796,024...126,799,361 		JBrowse link
G Cit citron rho-interacting serine/threonine kinase increases expression ISO Xylitol results in increased expression of CIT mRNA CTD PMID:32275922 NCBI chr12:46,263,881...46,425,642
Ensembl chr12:46,266,369...46,424,656 		JBrowse link
G Cycs cytochrome c, somatic decreases expression ISO Xylitol results in decreased expression of CYCS mRNA CTD PMID:32275922 NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816 		JBrowse link
G Dct dopachrome tautomerase decreases expression ISO Xylitol results in decreased expression of DCT mRNA CTD PMID:32275922 NCBI chr15:101,469,159...101,508,029
Ensembl chr15:101,469,159...101,508,029 		JBrowse link
G Dcxr dicarbonyl and L-xylulose reductase increases chemical synthesis
multiple interactions 		ISO DCXR protein results in increased chemical synthesis of Xylitol
[DCXR protein results in increased metabolism of Xylulose] which results in increased chemical synthesis of Xylitol 		CTD PMID:28595002 NCBI chr10:106,504,730...106,506,619 JBrowse link
G Flna filamin A increases expression ISO Xylitol results in increased expression of FLNA mRNA CTD PMID:32275922 NCBI chr  X:157,159,051...157,185,559
Ensembl chr  X:157,159,051...157,182,343 		JBrowse link
G Fmn1 formin 1 increases expression ISO Xylitol results in increased expression of FMN1 mRNA CTD PMID:32275922 NCBI chr 3:120,555,445...120,939,978
Ensembl chr 3:120,555,431...120,933,124 		JBrowse link
G Foxk1 forkhead box K1 increases expression ISO Xylitol results in increased expression of FOXK1 mRNA CTD PMID:32275922 NCBI chr12:17,223,599...17,288,564
Ensembl chr12:17,229,430...17,288,564 		JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 multiple interactions ISO [Aminooxyacetic Acid co-treated with Xylitol] results in increased expression of G6PC1 mRNA CTD PMID:31974165 NCBI chr10:86,807,659...86,819,023
Ensembl chr10:86,757,899...86,818,033 		JBrowse link
G Gpd2 glycerol-3-phosphate dehydrogenase 2 multiple interactions ISO [Aminooxyacetic Acid co-treated with Xylitol] results in increased expression of GPD2 mRNA CTD PMID:31974165 NCBI chr 3:62,209,432...62,346,590
Ensembl chr 3:62,210,814...62,346,593 		JBrowse link
G Gpm6b glycoprotein m6b decreases expression ISO Xylitol results in decreased expression of GPM6B mRNA CTD PMID:32275922 NCBI chr  X:31,689,485...31,836,199
Ensembl chr  X:31,690,359...31,733,272 		JBrowse link
G Hipk2 homeodomain interacting protein kinase 2 increases expression ISO Xylitol results in increased expression of HIPK2 mRNA CTD PMID:32275922 NCBI chr 4:68,399,358...68,586,404
Ensembl chr 4:68,369,099...68,586,108 		JBrowse link
G Hmcn1 hemicentin 1 increases expression ISO Xylitol results in increased expression of HMCN1 mRNA CTD PMID:32275922 NCBI chr13:65,165,532...65,634,681
Ensembl chr13:65,165,532...65,634,519 		JBrowse link
G Hnrnpul2 heterogeneous nuclear ribonucleoprotein U-like 2 increases expression ISO Xylitol results in increased expression of HNRNPUL2 mRNA CTD PMID:32275922 NCBI chr 1:215,142,750...215,154,668
Ensembl chr 1:215,142,644...215,155,161 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression
multiple interactions 		ISO Xylitol results in increased expression of HSPA5 protein
ursodoxicoltaurine inhibits the reaction [Xylitol results in increased expression of HSPA5 protein] 		CTD PMID:32275922 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790 		JBrowse link
G Inhba inhibin subunit beta A increases expression ISO Xylitol results in increased expression of INHBA mRNA CTD PMID:32275922 NCBI chr17:53,787,159...53,810,942
Ensembl chr17:53,791,444...53,804,508 		JBrowse link
G Iqgap3 IQ motif containing GTPase activating protein 3 increases expression ISO Xylitol results in increased expression of IQGAP3 mRNA CTD PMID:32275922 NCBI chr 2:175,840,001...175,881,799
Ensembl chr 2:175,839,949...175,881,797 		JBrowse link
G Kmt2d lysine methyltransferase 2D increases expression ISO Xylitol results in increased expression of KMT2D mRNA CTD PMID:32275922 NCBI chr 7:131,859,696...131,901,032
Ensembl chr 7:131,859,696...131,900,072 		JBrowse link
G Lsm5 LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated decreases expression ISO Xylitol results in decreased expression of LSM5 mRNA CTD PMID:32275922 NCBI chr 4:87,281,260...87,284,476
Ensembl chr 4:87,281,260...87,284,476
Ensembl chr 6:87,281,260...87,284,476 		JBrowse link
G Macf1 microtubule-actin crosslinking factor 1 increases expression ISO Xylitol results in increased expression of MACF1 mRNA CTD PMID:32275922 NCBI chr 5:140,908,829...141,234,127
Ensembl chr 5:140,908,837...141,233,890 		JBrowse link
G Mafk MAF bZIP transcription factor K increases expression ISO Xylitol results in increased expression of MAFK mRNA CTD PMID:32275922 NCBI chr12:19,948,473...19,970,351
Ensembl chr12:19,948,476...19,959,192 		JBrowse link
G Map1b microtubule-associated protein 1B increases expression ISO Xylitol results in increased expression of MAP1B mRNA CTD PMID:32275922 NCBI chr 2:32,551,423...32,644,471
Ensembl chr 2:32,551,423...32,657,094 		JBrowse link
G Mlxipl MLX interacting protein-like multiple interactions
increases expression 		ISO [Aminooxyacetic Acid co-treated with Xylitol] results in increased expression of MLXIPL mRNA alternative form
Xylitol results in increased expression of MLXIPL mRNA alternative form 		CTD PMID:31974165 NCBI chr12:27,178,158...27,213,675
Ensembl chr12:27,178,158...27,213,660 		JBrowse link
G Mrpl34 mitochondrial ribosomal protein L34 decreases expression ISO Xylitol results in decreased expression of MRPL34 mRNA CTD PMID:32275922 NCBI chr16:18,186,447...18,187,182
Ensembl chr16:18,185,306...18,187,181 		JBrowse link
G Msmo1 methylsterol monooxygenase 1 decreases expression ISO Xylitol results in decreased expression of MSMO1 mRNA CTD PMID:32275922 NCBI chr16:29,747,113...29,764,360
Ensembl chr16:29,747,137...29,764,445 		JBrowse link
G Nkd1 NKD inhibitor of WNT signaling pathway 1 increases expression ISO Xylitol results in increased expression of NKD1 mRNA CTD PMID:32275922 NCBI chr19:34,649,803...34,722,846 JBrowse link
G Nsd2 nuclear receptor binding SET domain protein 2 increases expression ISO Xylitol results in increased expression of WHSC1 mRNA CTD PMID:32275922 NCBI chr14:81,057,727...81,135,866
Ensembl chr14:81,057,727...81,123,027 		JBrowse link
G Oat ornithine aminotransferase multiple interactions EXP Xylitol inhibits the reaction [Cyclic AMP results in increased activity of OAT protein] CTD PMID:2827574 NCBI chr 1:196,777,973...196,797,754
Ensembl chr 1:196,777,975...196,797,754 		JBrowse link
G Pir pirin decreases expression ISO Xylitol results in decreased expression of PIR mRNA CTD PMID:32275922 NCBI chr  X:33,740,428...33,851,049
Ensembl chr  X:33,740,429...33,851,049 		JBrowse link
G Pkd1 polycystin 1, transient receptor potential channel interacting increases expression ISO Xylitol results in increased expression of PKD1 mRNA CTD PMID:32275922 NCBI chr10:14,077,733...14,125,682
Ensembl chr10:14,078,679...14,125,681 		JBrowse link
G Pole DNA polymerase epsilon, catalytic subunit increases expression ISO Xylitol results in increased expression of POLE mRNA CTD PMID:32275922 NCBI chr12:52,005,155...52,053,761
Ensembl chr12:52,005,155...52,053,662 		JBrowse link
G Prrc2b proline-rich coiled-coil 2B increases expression ISO Xylitol results in increased expression of PRRC2B mRNA CTD PMID:32275922 NCBI chr 3:35,831,017...35,916,854
Ensembl chr 3:35,863,046...35,916,854 		JBrowse link
G Rab5if RAB5 interacting factor decreases expression ISO Xylitol results in decreased expression of RAB5IF mRNA CTD PMID:32275922 NCBI chr 3:165,818,060...165,828,071
Ensembl chr 3:165,816,588...165,828,067 		JBrowse link
G Rere arginine-glutamic acid dipeptide repeats increases expression ISO Xylitol results in increased expression of RERE mRNA CTD PMID:32275922 NCBI chr 5:166,048,770...166,380,559
Ensembl chr 5:166,048,844...166,380,558 		JBrowse link
G Rpp21 ribonuclease P/MRP subunit p21 decreases expression ISO Xylitol results in decreased expression of RPP21 mRNA CTD PMID:32275922 NCBI chr20:1,986,225...2,025,308
Ensembl chr20:2,023,186...2,025,308 		JBrowse link
G Slc45a2 solute carrier family 45, member 2 decreases expression ISO Xylitol results in decreased expression of SLC45A2 mRNA CTD PMID:32275922 NCBI chr 2:61,690,828...61,723,437
Ensembl chr 2:61,690,828...61,723,437 		JBrowse link
G Slco5a1 solute carrier organic anion transporter family, member 5A1 increases expression ISO Xylitol results in increased expression of SLCO5A1 mRNA CTD PMID:32275922 NCBI chr 5:11,012,001...11,141,180
Ensembl chr 5:11,012,075...11,141,177 		JBrowse link
G Socs4 suppressor of cytokine signaling 4 decreases expression ISO Xylitol results in decreased expression of SOCS4 mRNA CTD PMID:32275922 NCBI chr15:23,003,130...23,017,615
Ensembl chr15:23,002,883...23,022,499 		JBrowse link
G Spcs3 signal peptidase complex subunit 3 decreases expression ISO Xylitol results in decreased expression of SPCS3 mRNA CTD PMID:32275922 NCBI chr16:44,038,421...44,043,855
Ensembl chr16:44,038,278...44,046,394 		JBrowse link
G Srrm2 serine/arginine repetitive matrix 2 increases expression ISO Xylitol results in increased expression of SRRM2 mRNA CTD PMID:32275922 NCBI chr10:13,320,059...13,353,337
Ensembl chr10:13,320,059...13,353,337 		JBrowse link
G Tanc2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 increases expression ISO Xylitol results in increased expression of TANC2 mRNA CTD PMID:32275922 NCBI chr10:91,052,860...91,373,291
Ensembl chr10:91,053,067...91,368,570 		JBrowse link
G Tmed5 transmembrane p24 trafficking protein 5 decreases expression ISO Xylitol results in decreased expression of TMED5 mRNA CTD PMID:32275922 NCBI chr14:1,752,857...1,763,990
Ensembl chr14:1,752,745...1,773,389 		JBrowse link
G Tmem59 transmembrane protein 59 decreases expression ISO Xylitol results in decreased expression of TMEM59 mRNA CTD PMID:32275922 NCBI chr 5:127,191,320...127,212,436
Ensembl chr 5:127,191,030...127,217,531 		JBrowse link
G Tmem64 transmembrane protein 64 decreases expression ISO Xylitol results in decreased expression of TMEM64 mRNA CTD PMID:32275922 NCBI chr 5:33,495,992...33,542,390
Ensembl chr 5:33,496,032...33,542,389 		JBrowse link
G Tnks tankyrase increases expression ISO Xylitol results in increased expression of TNKS mRNA CTD PMID:32275922 NCBI chr16:63,922,969...64,073,972
Ensembl chr16:63,928,281...64,079,282 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20871
    role 20829
      biological role 20827
        hapten 3096
          xylitol 53
            xylitol 5-phosphate 0
            xylitol 5-phosphate(2-) 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20871
    subatomic particle 20869
      composite particle 20869
        hadron 20869
          baryon 20869
            nucleon 20869
              atomic nucleus 20869
                atom 20869
                  main group element atom 20792
                    p-block element atom 20792
                      carbon group element atom 20725
                        carbon atom 20721
                          organic molecular entity 20721
                            heteroorganic entity 20226
                              organochalcogen compound 19911
                                organooxygen compound 19814
                                  carbohydrates and carbohydrate derivatives 15475
                                    carbohydrate 15475
                                      alditol 3332
                                        pentitol 54
                                          xylitol 53
                                            xylitol 5-phosphate 0
                                            xylitol 5-phosphate(2-) 0
paths to the root