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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:xylitol
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Accession:CHEBI:17151 term browser browse the term
Definition:A pentitol (five-carbon sugar alcohol) having meso-configuration, being derived from xylose by reduction of the carbonyl group.
Synonyms:exact_synonym: (2R,3r,4S)-pentane-1,2,3,4,5-pentol
 related_synonym: (2R,3R,4S)-Pentane-1,2,3,4,5-pentaol;   D-XYLITOL;   Formula=C5H12O5;   InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+;   InChIKey=HEBKCHPVOIAQTA-SCDXWVJYSA-N;   L-xylitol;   Meso-xylitol;   SMILES=OC[C@H](O)[C@@H](O)[C@H](O)CO;   Xylit;   xylite
 alt_id: CHEBI:10078;   CHEBI:15328;   CHEBI:253147;   CHEBI:27339;   CHEBI:46522;   CHEBI:60939
 xref: Beilstein:1720523;   CAS:87-99-0;   DrugBank:DB01904;   Drug_Central:4604;   Gmelin:82893;   HMDB:HMDB0002917;   KEGG:C00379;   KEGG:D00061
 xref_mesh: MESH:D014993
 xref: MetaCyc:XYLITOL;   PDBeChem:XYL;   PMID:11154411;   PMID:11163479;   PMID:12061879;   PMID:15377394;   PMID:16708791;   PMID:16901854;   PMID:17216457;   PMID:17216458;   PMID:17336832;   PMID:17979222;   PMID:18316079;   PMID:20030329;   PMID:22735334;   PMID:22791282;   PMID:23247825;   PMID:23287496;   PMID:23338824;   PMID:23589387;   PMID:23597921;   PMID:23615861;   PMID:23796483;   PMID:23916161;   PMID:23957303;   PMID:24012734;   PMID:24643482;   PMID:25108762;   Reaxys:1720523;   Wikipedia:Xylitol


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xylitol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl2 ABL proto-oncogene 2, non-receptor tyrosine kinase increases expression ISO Xylitol results in increased expression of ABL2 mRNA CTD PMID:32275922 NCBI chr13:68,673,702...68,770,846
Ensembl chr13:68,673,722...68,839,742 		JBrowse link
G Arhgef2 Rho/Rac guanine nucleotide exchange factor 2 increases expression ISO Xylitol results in increased expression of ARHGEF2 mRNA CTD PMID:32275922 NCBI chr 2:174,061,126...174,118,355
Ensembl chr 2:174,062,976...174,118,355 		JBrowse link
G Ash1l ASH1 like histone lysine methyltransferase increases expression ISO Xylitol results in increased expression of ASH1L mRNA CTD PMID:32275922 NCBI chr 2:174,346,267...174,483,057
Ensembl chr 2:174,346,150...174,483,055 		JBrowse link
G Atf4 activating transcription factor 4 increases expression ISO Xylitol results in increased expression of ATF4 protein CTD PMID:32275922 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Bcap29 B-cell receptor-associated protein 29 decreases expression ISO Xylitol results in decreased expression of BCAP29 mRNA CTD PMID:32275922 NCBI chr 6:48,182,702...48,222,698
Ensembl chr 6:48,182,706...48,222,720 		JBrowse link
G Birc6 baculoviral IAP repeat-containing 6 increases expression ISO Xylitol results in increased expression of BIRC6 mRNA CTD PMID:32275922 NCBI chr 6:20,722,922...20,916,396
Ensembl chr 6:20,722,922...20,916,434 		JBrowse link
G Casp3 caspase 3 increases expression ISO Xylitol results in increased expression of CASP3 protein modified form CTD PMID:32275922 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cep250 centrosomal protein 250 increases expression ISO Xylitol results in increased expression of CEP250 mRNA CTD PMID:32275922 NCBI chr 3:144,470,946...144,516,125
Ensembl chr 3:144,471,214...144,516,125 		JBrowse link
G Chac1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 multiple interactions
increases expression		 ISO ursodoxicoltaurine inhibits the reaction [Xylitol results in increased expression of CHAC1 protein]
Xylitol results in increased expression of CHAC1 mRNA; Xylitol results in increased expression of CHAC1 protein		 CTD PMID:32275922 NCBI chr 3:106,342,302...106,345,526
Ensembl chr 3:106,342,302...106,345,526 		JBrowse link
G Cit citron rho-interacting serine/threonine kinase increases expression ISO Xylitol results in increased expression of CIT mRNA CTD PMID:32275922 NCBI chr12:40,603,073...40,764,846
Ensembl chr12:40,605,563...40,763,860 		JBrowse link
G Cycs cytochrome c, somatic decreases expression ISO Xylitol results in decreased expression of CYCS mRNA CTD PMID:32275922 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Dct dopachrome tautomerase decreases expression ISO Xylitol results in decreased expression of DCT mRNA CTD PMID:32275922 NCBI chr15:95,062,006...95,100,863
Ensembl chr15:95,062,003...95,100,836 		JBrowse link
G Dcxr dicarbonyl and L-xylulose reductase increases chemical synthesis
multiple interactions		 ISO DCXR protein results in increased chemical synthesis of Xylitol
[DCXR protein results in increased metabolism of Xylulose] which results in increased chemical synthesis of Xylitol		 CTD PMID:28595002 NCBI chr10:106,006,404...106,008,293 JBrowse link
G Flna filamin A increases expression ISO Xylitol results in increased expression of FLNA mRNA CTD PMID:32275922 NCBI chr  X:152,007,758...152,034,266
Ensembl chr  X:152,007,758...152,031,052 		JBrowse link
G Fmn1 formin 1 increases expression ISO Xylitol results in increased expression of FMN1 mRNA CTD PMID:32275922 NCBI chr 3:100,101,103...100,485,652
Ensembl chr 3:100,134,549...100,479,220 		JBrowse link
G Foxk1 forkhead box K1 increases expression ISO Xylitol results in increased expression of FOXK1 mRNA CTD PMID:32275922 NCBI chr12:12,110,119...12,175,089
Ensembl chr12:12,115,950...12,175,089 		JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 multiple interactions ISO [Aminooxyacetic Acid co-treated with Xylitol] results in increased expression of G6PC1 mRNA CTD PMID:31974165 NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804 		JBrowse link
G Gpd2 glycerol-3-phosphate dehydrogenase 2 multiple interactions ISO [Aminooxyacetic Acid co-treated with Xylitol] results in increased expression of GPD2 mRNA CTD PMID:31974165 NCBI chr 3:41,800,552...41,937,729
Ensembl chr 3:41,801,930...41,936,901 		JBrowse link
G Gpm6b glycoprotein m6b decreases expression ISO Xylitol results in decreased expression of GPM6B mRNA CTD PMID:32275922 NCBI chr  X:28,057,788...28,204,409
Ensembl chr  X:28,059,450...28,204,211 		JBrowse link
G Hipk2 homeodomain interacting protein kinase 2 increases expression ISO Xylitol results in increased expression of HIPK2 mRNA CTD PMID:32275922 NCBI chr 4:67,439,327...67,619,223
Ensembl chr 4:67,440,501...67,619,223 		JBrowse link
G Hmcn1 hemicentin 1 increases expression ISO Xylitol results in increased expression of HMCN1 mRNA CTD PMID:32275922 NCBI chr13:62,615,461...63,084,524
Ensembl chr13:62,615,461...63,084,524 		JBrowse link
G Hnrnpul2 heterogeneous nuclear ribonucleoprotein U-like 2 increases expression ISO Xylitol results in increased expression of HNRNPUL2 mRNA CTD PMID:32275922 NCBI chr 1:205,713,431...205,725,553
Ensembl chr 1:205,711,886...205,725,553 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression
multiple interactions		 ISO Xylitol results in increased expression of HSPA5 protein
ursodoxicoltaurine inhibits the reaction [Xylitol results in increased expression of HSPA5 protein]		 CTD PMID:32275922 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Inhba inhibin subunit beta A increases expression ISO Xylitol results in increased expression of INHBA mRNA CTD PMID:32275922 NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982 		JBrowse link
G Iqgap3 IQ motif containing GTPase activating protein 3 increases expression ISO Xylitol results in increased expression of IQGAP3 mRNA CTD PMID:32275922 NCBI chr 2:173,542,151...173,583,956
Ensembl chr 2:173,542,110...173,583,956 		JBrowse link
G Kmt2d lysine methyltransferase 2D increases expression ISO Xylitol results in increased expression of KMT2D mRNA CTD PMID:32275922 NCBI chr 7:129,980,744...130,022,088
Ensembl chr 7:129,962,887...130,020,325 		JBrowse link
G Lsm5 LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated decreases expression ISO Xylitol results in decreased expression of LSM5 mRNA CTD PMID:32275922 NCBI chr 4:85,951,073...85,954,289
Ensembl chr 6:104,652,477...104,654,165
Ensembl chr 4:104,652,477...104,654,165 		JBrowse link
G Macf1 microtubule-actin crosslinking factor 1 increases expression ISO Xylitol results in increased expression of MACF1 mRNA CTD PMID:32275922 NCBI chr 5:135,623,734...135,949,097
Ensembl chr 5:135,623,742...135,945,905 		JBrowse link
G Mafk MAF bZIP transcription factor K increases expression ISO Xylitol results in increased expression of MAFK mRNA CTD PMID:32275922 NCBI chr12:14,834,628...14,856,414
Ensembl chr12:14,833,984...14,837,048
Ensembl chr12:14,833,984...14,837,048 		JBrowse link
G Map1b microtubule-associated protein 1B increases expression ISO Xylitol results in increased expression of MAP1B mRNA CTD PMID:32275922 NCBI chr 2:30,817,261...30,910,458
Ensembl chr 2:30,817,261...30,910,317 		JBrowse link
G Mlxipl MLX interacting protein-like multiple interactions
increases expression		 ISO [Aminooxyacetic Acid co-treated with Xylitol] results in increased expression of MLXIPL mRNA alternative form
Xylitol results in increased expression of MLXIPL mRNA alternative form		 CTD PMID:31974165 NCBI chr12:21,541,608...21,577,120
Ensembl chr12:21,543,576...21,577,112 		JBrowse link
G Mrpl34 mitochondrial ribosomal protein L34 decreases expression ISO Xylitol results in decreased expression of MRPL34 mRNA CTD PMID:32275922 NCBI chr16:18,152,470...18,153,205
Ensembl chr16:18,151,342...18,153,208 		JBrowse link
G Msmo1 methylsterol monooxygenase 1 decreases expression ISO Xylitol results in decreased expression of MSMO1 mRNA CTD PMID:32275922 NCBI chr16:24,980,680...24,997,927
Ensembl chr16:24,980,697...24,998,016 		JBrowse link
G Nkd1 NKD inhibitor of WNT signaling pathway 1 increases expression ISO Xylitol results in increased expression of NKD1 mRNA CTD PMID:32275922 NCBI chr19:18,476,344...18,549,380
Ensembl chr19:18,476,344...18,549,380 		JBrowse link
G Nsd2 nuclear receptor binding SET domain protein 2 increases expression ISO Xylitol results in increased expression of WHSC1 mRNA CTD PMID:32275922 NCBI chr14:76,833,179...76,911,304
Ensembl chr14:76,835,637...76,913,641 		JBrowse link
G Oat ornithine aminotransferase multiple interactions EXP Xylitol inhibits the reaction [Cyclic AMP results in increased activity of OAT protein] CTD PMID:2827574 NCBI chr 1:187,347,862...187,367,644
Ensembl chr 1:187,347,865...187,367,682 		JBrowse link
G Pir pirin decreases expression ISO Xylitol results in decreased expression of PIR mRNA CTD PMID:32275922 NCBI chr  X:30,108,536...30,219,269
Ensembl chr  X:30,108,538...30,219,218 		JBrowse link
G Pkd1 polycystin 1, transient receptor potential channel interacting increases expression ISO Xylitol results in increased expression of PKD1 mRNA CTD PMID:32275922 NCBI chr10:13,573,779...13,621,138
Ensembl chr10:13,573,021...13,621,128 		JBrowse link
G Pole DNA polymerase epsilon, catalytic subunit increases expression ISO Xylitol results in increased expression of POLE mRNA CTD PMID:32275922 NCBI chr12:46,345,420...46,393,984
Ensembl chr12:46,345,420...46,393,939 		JBrowse link
G Prrc2b proline-rich coiled-coil 2B increases expression ISO Xylitol results in increased expression of PRRC2B mRNA CTD PMID:32275922 NCBI chr 3:15,433,357...15,519,105
Ensembl chr 3:15,465,294...15,519,104 		JBrowse link
G Rab5if RAB5 interacting factor decreases expression ISO Xylitol results in decreased expression of RAB5IF mRNA CTD PMID:32275922 NCBI chr 3:145,357,990...145,368,012
Ensembl chr 3:145,357,861...145,368,012 		JBrowse link
G Rere arginine-glutamic acid dipeptide repeats increases expression ISO Xylitol results in increased expression of RERE mRNA CTD PMID:32275922 NCBI chr 5:160,765,855...161,097,678
Ensembl chr 5:160,765,934...161,097,677 		JBrowse link
G Rpp21 ribonuclease P/MRP subunit p21 decreases expression ISO Xylitol results in decreased expression of RPP21 mRNA CTD PMID:32275922 NCBI chr20:2,018,170...2,020,100
Ensembl chr20:2,018,147...2,020,106 		JBrowse link
G Slc45a2 solute carrier family 45, member 2 decreases expression ISO Xylitol results in decreased expression of SLC45A2 mRNA CTD PMID:32275922 NCBI chr 2:59,963,599...59,996,408
Ensembl chr 2:59,963,706...59,996,317 		JBrowse link
G Slco5a1 solute carrier organic anion transporter family, member 5A1 increases expression ISO Xylitol results in increased expression of SLCO5A1 mRNA CTD PMID:32275922 NCBI chr 5:6,228,938...6,358,124
Ensembl chr 5:6,228,973...6,352,913 		JBrowse link
G Socs4 suppressor of cytokine signaling 4 decreases expression ISO Xylitol results in decreased expression of SOCS4 mRNA CTD PMID:32275922 NCBI chr15:20,523,406...20,537,889
Ensembl chr15:20,523,183...20,542,494 		JBrowse link
G Spcs3 signal peptidase complex subunit 3 decreases expression ISO Xylitol results in decreased expression of SPCS3 mRNA CTD PMID:32275922 NCBI chr16:37,305,358...37,310,792
Ensembl chr16:37,305,305...37,331,746 		JBrowse link
G Srrm2 serine/arginine repetitive matrix 2 increases expression ISO Xylitol results in increased expression of SRRM2 mRNA CTD PMID:32275922 NCBI chr10:12,815,471...12,848,750
Ensembl chr10:12,815,471...12,848,751 		JBrowse link
G Tanc2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 increases expression ISO Xylitol results in increased expression of TANC2 mRNA CTD PMID:32275922 NCBI chr10:90,553,124...90,873,477
Ensembl chr10:90,553,002...90,868,756 		JBrowse link
G Tmed5 transmembrane p24 trafficking protein 5 decreases expression ISO Xylitol results in decreased expression of TMED5 mRNA CTD PMID:32275922 NCBI chr14:1,607,895...1,619,028
Ensembl chr14:1,607,819...1,628,426 		JBrowse link
G Tmem59 transmembrane protein 59 decreases expression ISO Xylitol results in decreased expression of TMEM59 mRNA CTD PMID:32275922 NCBI chr 5:121,962,507...121,983,625
Ensembl chr 5:121,962,440...121,983,625 		JBrowse link
G Tmem64 transmembrane protein 64 decreases expression ISO Xylitol results in decreased expression of TMEM64 mRNA CTD PMID:32275922 NCBI chr 5:28,698,947...28,745,384
Ensembl chr 5:28,698,918...28,745,330 		JBrowse link
G Tnks tankyrase increases expression ISO Xylitol results in increased expression of TNKS mRNA CTD PMID:32275922 NCBI chr16:57,223,174...57,370,740
Ensembl chr16:57,225,094...57,366,260 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    role 19854
      biological role 19852
        hapten 3059
          xylitol 53
            xylitol 5-phosphate 0
            xylitol 5-phosphate(2-) 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    p-block element atom 19849
                      carbon group element atom 19766
                        carbon atom 19785
                          organic molecular entity 19785
                            heteroorganic entity 19541
                              organochalcogen compound 19301
                                organooxygen compound 19193
                                  carbohydrates and carbohydrate derivatives 15275
                                    carbohydrate 15302
                                      alditol 3298
                                        pentitol 54
                                          xylitol 53
                                            xylitol 5-phosphate 0
                                            xylitol 5-phosphate(2-) 0
paths to the root