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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:octopamine
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Accession:CHEBI:17134 term browser browse the term
Definition:A member of the class of phenylethanolamines that is phenol which is substituted at the para- position by a 2-amino-1-hydroxyethyl group. A biogenic phenylethanolamine which has been found to act as a neurotransmitter, neurohormone or neuromodulator in invertebrates.
Synonyms:exact_synonym: 4-(2-amino-1-hydroxyethyl)phenol
 related_synonym: 1-(4-Hydroxyphenyl)-2-aminoethanol;   1-(p-hydroxyphenyl)-2-aminoethanol;   Formula=C8H11NO2;   InChI=1S/C8H11NO2/c9-5-8(11)6-1-3-7(10)4-2-6/h1-4,8,10-11H,5,9H2;   InChIKey=QHGUCRYDKWKLMG-UHFFFAOYSA-N;   Octopamin;   SMILES=NCC(O)c1ccc(O)cc1;   alpha-(aminomethyl)-4-hydroxybenzenemethanol;   alpha-(aminomethyl)-p-hydroxybenzyl alcohol;   beta-hydroxytyramine;   norsynephrine;   octopaminum;   p-Hydroxyphenylethanolamine
 alt_id: CHEBI:11191;   CHEBI:25655;   CHEBI:571
 xref: Beilstein:1211019;   CAS:104-14-3;   Drug_Central:3396;   KEGG:C04227;   LINCS:LSM-4975
 xref_mesh: MESH:D009655
 cyclic_relationship: is_conjugate_base_of CHEBI:58025


show annotations for term's descendants           Sort by:
octopamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenoceptor beta 1 multiple interactions ISO Octopamine inhibits the reaction [Norepinephrine binds to ADRB1 protein] CTD PMID:10344530 NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259 		JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions ISO Octopamine inhibits the reaction [Norepinephrine binds to ADRB2 protein] CTD PMID:10344530 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512 		JBrowse link
G Adrb3 adrenoceptor beta 3 increases activity
multiple interactions		 EXP
ISO		 Octopamine results in increased activity of ADRB3 protein
Octopamine inhibits the reaction [Norepinephrine binds to ADRB3 protein]		 CTD PMID:10344530 NCBI chr16:64,839,820...64,844,552
Ensembl chr16:64,841,788...64,844,552 		JBrowse link
G Slc6a2 solute carrier family 6 member 2 multiple interactions ISO Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; indatraline inhibits the reaction [SLC6A2 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; SLC6A2 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein] CTD PMID:17234900 NCBI chr19:14,010,292...14,055,317
Ensembl chr19:14,010,386...14,050,357 		JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions ISO indatraline inhibits the reaction [SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein] CTD PMID:17234900 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413 		JBrowse link
G Slc6a4 solute carrier family 6 member 4 multiple interactions ISO Citalopram inhibits the reaction [SLC6A4 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; indatraline inhibits the reaction [SLC6A4 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; SLC6A4 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein] CTD PMID:17234900 NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384 		JBrowse link
G Taar1 trace-amine-associated receptor 1 multiple interactions
increases activity		 ISO [Octopamine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP; Citalopram inhibits the reaction [SLC6A4 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; indatraline inhibits the reaction [SLC6A2 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; indatraline inhibits the reaction [SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; indatraline inhibits the reaction [SLC6A4 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; SLC6A2 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]; SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]; SLC6A4 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein] CTD PMID:17234900 PMID:19725810 NCBI chr 1:21,517,742...21,518,740
Ensembl chr 1:21,517,258...21,532,084 		JBrowse link
(R)-octopamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenoceptor beta 1 multiple interactions ISO Octopamine inhibits the reaction [Norepinephrine binds to ADRB1 protein] CTD PMID:10344530 NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259 		JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions ISO Octopamine inhibits the reaction [Norepinephrine binds to ADRB2 protein] CTD PMID:10344530 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512 		JBrowse link
G Adrb3 adrenoceptor beta 3 increases activity
multiple interactions		 EXP
ISO		 Octopamine results in increased activity of ADRB3 protein
Octopamine inhibits the reaction [Norepinephrine binds to ADRB3 protein]		 CTD PMID:10344530 NCBI chr16:64,839,820...64,844,552
Ensembl chr16:64,841,788...64,844,552 		JBrowse link
G Slc6a2 solute carrier family 6 member 2 multiple interactions ISO Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; indatraline inhibits the reaction [SLC6A2 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; SLC6A2 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein] CTD PMID:17234900 NCBI chr19:14,010,292...14,055,317
Ensembl chr19:14,010,386...14,050,357 		JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions ISO indatraline inhibits the reaction [SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein] CTD PMID:17234900 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413 		JBrowse link
G Slc6a4 solute carrier family 6 member 4 multiple interactions ISO Citalopram inhibits the reaction [SLC6A4 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; indatraline inhibits the reaction [SLC6A4 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; SLC6A4 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein] CTD PMID:17234900 NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384 		JBrowse link
G Taar1 trace-amine-associated receptor 1 multiple interactions
increases activity		 ISO [Octopamine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP; Citalopram inhibits the reaction [SLC6A4 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; indatraline inhibits the reaction [SLC6A2 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; indatraline inhibits the reaction [SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; indatraline inhibits the reaction [SLC6A4 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; SLC6A2 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]; SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]; SLC6A4 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein] CTD PMID:17234900 PMID:19725810 NCBI chr 1:21,517,742...21,518,740
Ensembl chr 1:21,517,258...21,532,084 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      biological role 19848
        molecular messenger 18665
          neurotransmitter 11680
            octopamine 7
              (R)-octopamine + 7
              (S)-octopamine 0
              N-acetyloctopamine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    main group molecular entity 19817
                      s-block molecular entity 19653
                        hydrogen molecular entity 19634
                          hydrides 19144
                            inorganic hydride 18161
                              pnictogen hydride 18151
                                nitrogen hydride 18064
                                  azane 17872
                                    ammonia 17871
                                      organic amino compound 17871
                                        amino alcohol 1075
                                          ethanolamines 826
                                            phenylethanolamines 608
                                              octopamine 7
                                                (R)-octopamine + 7
                                                (S)-octopamine 0
                                                N-acetyloctopamine 0
paths to the root