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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:L-aspartic acid
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Accession:CHEBI:17053 term browser browse the term
Definition:The L-enantiomer of aspartic acid.
Synonyms:exact_synonym: (2S)-2-aminobutanedioic acid
 related_synonym: (S)-2-aminobutanedioic acid;   (S)-2-aminosuccinic acid;   2-Aminosuccinic acid;   ASPARTIC ACID;   Asp;   D;   Formula=C4H7NO4;   InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/t2-/m0/s1;   InChIKey=CKLJMWTZIZZHCS-REOHCLBHSA-N;   L-Asparaginsaeure;   SMILES=N[C@@H](CC(O)=O)C(O)=O
 alt_id: CHEBI:21247;   CHEBI:40853;   CHEBI:40900;   CHEBI:40913;   CHEBI:40942;   CHEBI:6193
 xref: CAS:56-84-8;   DrugBank:DB00128;   Drug_Central:1550;   ECMDB:ECMDB00191;   Gmelin:3333;   HMDB:HMDB0000191;   KEGG:C00049;   KEGG:D00013;   KNApSAcK:C00001342
 xref_mesh: MESH:D001224
 xref: MetaCyc:L-ASPARTATE;   PDBeChem:ASP;   PMID:11568288;   PMID:21359215;   PMID:22770225;   Reaxys:1723530;   YMDB:YMDB00896
 cyclic_relationship: is_conjugate_acid_of CHEBI:29991;   is_enantiomer_of CHEBI:17364



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L-aspartic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Egf epidermal growth factor multiple interactions EXP [bafilomycin A1 co-treated with EGF protein] results in increased abundance of Aspartic Acid CTD PMID:22689575 NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:220,893,660...220,976,297
JBrowse link
G Mapt microtubule-associated protein tau multiple interactions
decreases abundance
ISO PF-06840003 inhibits the reaction [MAPT protein mutant form results in decreased abundance of Aspartic Acid] CTD PMID:39172838 NCBI chr10:89,638,618...89,736,108
Ensembl chr10:89,638,599...89,736,108
JBrowse link
G Srr serine racemase increases metabolic processing
affects abundance
multiple interactions
ISO SRR protein results in increased metabolism of Aspartic Acid
SRR protein affects the abundance of Aspartic Acid
[SRR protein results in increased metabolism of Aspartic Acid] which results in increased abundance of D-Aspartic Acid
CTD PMID:27387750 NCBI chr10:60,267,936...60,285,094
Ensembl chr10:60,268,859...60,285,100
JBrowse link
Ac-Asp-Glu term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Folh1 folate hydrolase 1 affects binding
multiple interactions
ISO isospaglumic acid binds to FOLH1 protein
[2-(3-(1,3-dicarboxypropyl)ureido)pentanedioic acid binds to Aminocaproic Acid binds to 1-(1,3-carboxypropyl)-4,7-carboxymethyl-1,4,7-triazacyclononane binds to Valerates binds to bombesin (7-14) binds to Copper] inhibits the reaction [isospaglumic acid binds to FOLH1 protein]
CTD PMID:24508213 NCBI chr 1:149,828,286...149,914,313
Ensembl chr 1:149,840,760...149,914,035
JBrowse link
aspartame term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ABCA1 mRNA CTD PMID:23783067 NCBI chr 5:72,473,676...72,596,563
Ensembl chr 5:72,473,676...72,596,473
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ABCB4 mRNA CTD PMID:23783067 NCBI chr 4:26,106,895...26,164,440 JBrowse link
G Abcd1 ATP binding cassette subfamily D member 1 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of ABCD1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ABCD1 mRNA CTD PMID:23783067 NCBI chr  X:156,579,669...156,601,448
Ensembl chr  X:156,579,785...156,601,446
JBrowse link
G Abcd2 ATP binding cassette subfamily D member 2 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ABCD2 mRNA CTD PMID:23783067 NCBI chr 7:124,142,597...124,191,202
Ensembl chr 7:124,142,595...124,191,202
JBrowse link
G Acaa1a acetyl-CoA acyltransferase 1A multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of ACAA1A mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ACAA1A mRNA CTD PMID:23783067 NCBI chr 8:127,956,126...127,966,348
Ensembl chr 8:127,956,129...127,966,241
JBrowse link
G Acaa1b acetyl-Coenzyme A acyltransferase 1B multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ACAA1B mRNA CTD PMID:23783067 NCBI chr 8:118,872,996...118,881,852
Ensembl chr 8:127,750,743...127,759,569
JBrowse link
G Acacb acetyl-CoA carboxylase beta multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ACACB mRNA CTD PMID:23783067 NCBI chr12:48,026,394...48,138,214
Ensembl chr12:48,026,394...48,138,214
JBrowse link
G Acads acyl-CoA dehydrogenase short chain multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of ACADS mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ACADS mRNA CTD PMID:23783067 NCBI chr12:41,493,650...41,502,897
Ensembl chr12:47,154,276...47,164,103
JBrowse link
G Acadvl acyl-CoA dehydrogenase, very long chain multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of ACADVL mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ACADVL mRNA CTD PMID:23783067 NCBI chr10:55,231,558...55,236,786
Ensembl chr10:55,231,440...55,236,750
JBrowse link
G Ache acetylcholinesterase decreases activity ISO
EXP
Aspartame metabolite results in decreased activity of ACHE protein CTD PMID:16129618 PMID:17580119 PMID:17673349 NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410
JBrowse link
G Aco1 aconitase 1 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of ACO1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ACO1 mRNA CTD PMID:23783067 NCBI chr 5:55,259,841...55,315,872
Ensembl chr 5:60,055,866...60,112,600
JBrowse link
G Acot1 acyl-CoA thioesterase 1 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ACOT1 mRNA CTD PMID:23783067 NCBI chr 6:109,367,274...109,375,268
Ensembl chr 6:109,367,268...109,380,749
JBrowse link
G Adgre1 adhesion G protein-coupled receptor E1 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ADGRE1 mRNA CTD PMID:23783067 NCBI chr 9:2,329,398...2,484,959
Ensembl chr 9:2,329,438...2,484,959
JBrowse link
G Agt angiotensinogen decreases expression ISO Aspartame results in decreased expression of AGT mRNA CTD PMID:31655124 NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944
JBrowse link
G Agtr1a angiotensin II receptor, type 1a decreases expression ISO Aspartame results in decreased expression of AGTR1 mRNA CTD PMID:31655124 NCBI chr17:34,383,397...34,435,523
Ensembl chr17:34,381,467...34,435,660
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation ISO Aspartame results in increased phosphorylation of AKT1 protein CTD PMID:33992720 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610
JBrowse link
G Alox15 arachidonate 15-lipoxygenase multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ALOX15 mRNA CTD PMID:23783067 NCBI chr10:55,559,060...55,567,535
Ensembl chr10:55,559,061...55,567,723
JBrowse link
G Apoe apolipoprotein E decreases expression ISO Aspartame results in decreased expression of APOE mRNA CTD PMID:31655124 NCBI chr 1:88,481,889...88,485,816
Ensembl chr 1:88,481,385...88,485,855
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
EXP
ISO
[Aspartame co-treated with Methotrexate] results in increased expression of BAX mRNA; [Aspartame co-treated with Methotrexate] results in increased expression of BAX protein
[Fats, Unsaturated co-treated with Aspartame] affects the expression of BAX mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of BAX mRNA
Aspartame results in increased expression of BAX mRNA
CTD PMID:23783067 PMID:25009784 PMID:32951320 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
EXP
ISO
[Aspartame co-treated with Methotrexate] results in decreased expression of BCL2 mRNA; [Aspartame co-treated with Methotrexate] results in decreased expression of BCL2 protein
Aspartame results in decreased expression of BCL2 mRNA
CTD PMID:25009784 PMID:32951320 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
JBrowse link
G Cabp2 calcium binding protein 2 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of CABP2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CABP2 mRNA CTD PMID:23783067 NCBI chr 1:201,374,649...201,380,469
Ensembl chr 1:210,804,096...210,809,940
JBrowse link
G Cacna1a calcium voltage-gated channel subunit alpha1 A multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of CACNA1A mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CACNA1A mRNA CTD PMID:23783067 NCBI chr19:40,425,560...40,724,810
Ensembl chr19:40,425,560...40,724,599
JBrowse link
G Cacna1i calcium voltage-gated channel subunit alpha1 I multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of CACNA1I mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CACNA1I mRNA CTD PMID:23783067 NCBI chr 7:113,716,266...113,827,670
Ensembl chr 7:113,716,266...113,827,670
JBrowse link
G Cacna2d4 calcium voltage-gated channel auxiliary subunit alpha2delta 4 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of CACNA2D4 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CACNA2D4 mRNA CTD PMID:23783067 NCBI chr 4:152,408,588...152,521,478
Ensembl chr 4:154,080,877...154,193,778
JBrowse link
G Cacnb2 calcium voltage-gated channel auxiliary subunit beta 2 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of CACNB2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CACNB2 mRNA CTD PMID:23783067 NCBI chr17:77,564,630...77,910,000
Ensembl chr17:82,473,129...82,818,564
JBrowse link
G Cacng4 calcium voltage-gated channel auxiliary subunit gamma 4 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of CACNG4 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CACNG4 mRNA CTD PMID:23783067 NCBI chr10:92,683,778...92,745,842
Ensembl chr10:93,183,410...93,245,470
JBrowse link
G Cacng8 calcium voltage-gated channel auxiliary subunit gamma 8 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of CACNG8 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CACNG8 mRNA CTD PMID:23783067 NCBI chr 1:65,755,334...65,775,567
Ensembl chr 1:74,669,766...74,694,015
JBrowse link
G Calhm2 calcium homeostasis modulator family member 2 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of CALHM2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CALHM2 mRNA CTD PMID:23783067 NCBI chr 1:255,963,661...255,969,387
Ensembl chr 1:255,963,663...255,969,387
JBrowse link
G Calr3 calreticulin 3 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of CALR3 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CALR3 mRNA CTD PMID:23783067 NCBI chr16:17,396,064...17,423,166
Ensembl chr16:17,430,153...17,457,198
JBrowse link
G Cant1 calcium activated nucleotidase 1 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of CANT1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CANT1 mRNA CTD PMID:23783067 NCBI chr10:104,135,676...104,148,854
Ensembl chr10:104,135,682...104,148,698
JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
EXP
ISO
[Aspartame co-treated with Methotrexate] results in increased expression of CASP3 mRNA; [Aspartame co-treated with Methotrexate] results in increased expression of CASP3 protein modified form
Aspartame results in increased expression of CASP3 mRNA
CTD PMID:25009784 PMID:32951320 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
JBrowse link
G Casp9 caspase 9 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of CASP9 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CASP9 mRNA CTD PMID:23783067 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Cat catalase multiple interactions
decreases activity
EXP
ISO
[Aspartame co-treated with Methotrexate] results in increased activity of CAT protein
Aspartame results in decreased activity of CAT protein
CTD PMID:25009784 PMID:32951320 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] results in increased expression of CCL2 protein; [Sodium Glutamate co-treated with Aspartame] inhibits the reaction [Fats, Unsaturated results in increased expression of CCL2 protein] CTD PMID:23783067 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875
JBrowse link
G Cdh1 cadherin 1 decreases expression ISO Aspartame results in decreased expression of CDH1 protein CTD PMID:33992720 NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A affects localization
multiple interactions
ISO Aspartame affects the localization of CDKN1A protein
TAS1R1 protein affects the reaction [Aspartame affects the localization of CDKN1A protein]
CTD PMID:33992720 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions
decreases expression
ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CDKN1B mRNA
Aspartame results in decreased expression of CDKN1B protein
CTD PMID:23783067 PMID:33992720 NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498
JBrowse link
G Cherp calcium homeostasis endoplasmic reticulum protein multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of CHERP mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CHERP mRNA CTD PMID:23783067 NCBI chr16:17,401,497...17,414,549
Ensembl chr16:17,401,497...17,414,549
JBrowse link
G Cmc1 C-x(9)-C motif containing 1 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of CMC1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CMC1 mRNA CTD PMID:23783067 NCBI chr 8:117,798,036...117,900,458
Ensembl chr 8:126,677,560...126,778,499
JBrowse link
G Cox11 cytochrome c oxidase copper chaperone COX11 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of COX11 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of COX11 mRNA CTD PMID:23783067 NCBI chr10:75,458,735...75,465,322
Ensembl chr10:75,955,783...75,963,489
JBrowse link
G Cox7a1 cytochrome c oxidase subunit 7A1 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of COX7A1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of COX7A1 mRNA CTD PMID:23783067 NCBI chr 1:94,549,663...94,572,330
Ensembl chr 1:94,569,216...94,570,889
JBrowse link
G Cpt1b carnitine palmitoyltransferase 1B multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of CPT1B mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CPT1B mRNA CTD PMID:23783067 NCBI chr 7:122,370,974...122,380,473
Ensembl chr 7:122,370,444...122,380,036
JBrowse link
G Cpt1c carnitine palmitoyltransferase 1c multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CPT1C mRNA CTD PMID:23783067 NCBI chr 1:104,579,297...104,593,824
Ensembl chr 1:104,579,298...104,593,763
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CREB1 mRNA CTD PMID:23783067 NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339
JBrowse link
G Csf1 colony stimulating factor 1 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CSF1 mRNA CTD PMID:23783067 NCBI chr 2:198,065,400...198,084,774
Ensembl chr 2:198,065,405...198,084,468
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases activity EXP Aspartame results in increased activity of CYP1A1 protein CTD PMID:16937917 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases activity EXP Aspartame results in increased activity of CYP1A2 protein CTD PMID:16937917 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions EXP Aspartame results in increased expression of and results in increased activity of CYP2B1 protein CTD PMID:16937917 NCBI chr 1:90,646,098...90,669,762 JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases activity EXP Aspartame results in increased activity of CYP2B2 protein CTD PMID:16937917 NCBI chr 1:90,722,243...90,736,272 JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP Aspartame results in increased expression of and results in increased activity of CYP2E1 protein CTD PMID:16937917 NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495
JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 increases activity EXP Aspartame results in increased activity of CYP3A62 protein CTD PMID:16937917 NCBI chr12:16,397,998...16,433,833
Ensembl chr12:21,471,542...21,547,598
JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of DIABLO mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of DIABLO mRNA CTD PMID:23783067 NCBI chr12:38,716,668...38,731,285
Ensembl chr12:38,716,668...38,731,265
JBrowse link
G Dnajc27 DnaJ heat shock protein family (Hsp40) member C27 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of DNAJC27 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of DNAJC27 mRNA CTD PMID:23783067 NCBI chr 6:27,068,713...27,098,449
Ensembl chr 6:32,788,184...32,817,940
JBrowse link
G E2f1 E2F transcription factor 1 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of E2F1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of E2F1 mRNA CTD PMID:23783067 NCBI chr 3:163,524,739...163,535,563
Ensembl chr 3:163,524,739...163,535,563
JBrowse link
G Edn2 endothelin 2 decreases expression ISO Aspartame results in decreased expression of EDN2 mRNA CTD PMID:31655124 NCBI chr 5:133,751,316...133,756,814
Ensembl chr 5:139,036,492...139,043,070
JBrowse link
G Ednra endothelin receptor type A decreases expression ISO Aspartame results in decreased expression of EDNRA mRNA CTD PMID:31655124 NCBI chr19:47,137,360...47,207,961
Ensembl chr19:47,137,771...47,201,284
JBrowse link
G Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of EHHADH mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of EHHADH mRNA CTD PMID:23783067 NCBI chr11:92,746,409...92,779,647
Ensembl chr11:92,746,420...92,779,662
JBrowse link
G Ephx2 epoxide hydrolase 2 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of EPHX2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of EPHX2 mRNA CTD PMID:23783067 NCBI chr15:44,465,447...44,503,157
Ensembl chr15:44,465,448...44,503,160
JBrowse link
G F2 coagulation factor II, thrombin decreases activity ISO Aspartame analog results in decreased activity of F2 protein; Aspartame results in decreased activity of F2 protein CTD PMID:15572260 NCBI chr 3:98,051,958...98,065,246
Ensembl chr 3:98,051,960...98,065,246
JBrowse link
G Fgf1 fibroblast growth factor 1 increases expression ISO Aspartame results in increased expression of FGF1 mRNA CTD PMID:31655124 NCBI chr18:30,937,670...31,023,786
Ensembl chr18:30,939,870...30,961,393
JBrowse link
G Foxo3 forkhead box O3 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of FOXO3 mRNA CTD PMID:23783067 NCBI chr20:47,251,968...47,348,254
Ensembl chr20:47,255,878...47,346,845
JBrowse link
G Fshb follicle stimulating hormone subunit beta decreases expression ISO Aspartame results in decreased expression of FSHB protein CTD PMID:32951320 NCBI chr 3:114,003,262...114,007,072
Ensembl chr 3:114,003,262...114,007,072
JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of GADD45B mRNA CTD PMID:23783067 NCBI chr 7:9,428,689...9,430,991
Ensembl chr 7:9,428,689...9,430,718
JBrowse link
G Gfm2 GTP dependent ribosome recycling factor mitochondrial 2 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of GFM2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of GFM2 mRNA CTD PMID:23783067 NCBI chr 2:28,449,452...28,488,200
Ensembl chr 2:30,184,115...30,222,806
JBrowse link
G Gip gastric inhibitory polypeptide multiple interactions ISO Aspartame promotes the reaction [Fats, Unsaturated results in increased expression of GIP protein]; Sodium Glutamate inhibits the reaction [Aspartame promotes the reaction [Fats, Unsaturated results in increased expression of GIP protein]] CTD PMID:23783067 NCBI chr10:81,465,070...81,473,216
Ensembl chr10:81,465,062...81,473,216
JBrowse link
G Gli1 GLI family zinc finger 1 affects localization
multiple interactions
ISO Aspartame affects the localization of GLI1 protein
TAS1R1 protein affects the reaction [Aspartame affects the localization of GLI1 protein]
CTD PMID:33992720 NCBI chr 7:65,042,237...65,054,888
Ensembl chr 7:65,042,237...65,054,540
JBrowse link
G Gli2 GLI family zinc finger 2 decreases expression ISO Aspartame results in decreased expression of GLI2 protein CTD PMID:33992720 NCBI chr13:32,499,678...32,716,418
Ensembl chr13:32,499,678...32,716,418
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation ISO Aspartame results in increased phosphorylation of GSK3B protein CTD PMID:33992720 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP [Aspartame co-treated with Methotrexate] results in decreased activity of GSR protein CTD PMID:25009784 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394
JBrowse link
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of HADHA mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of HADHA mRNA CTD PMID:23783067 NCBI chr 6:26,187,969...26,227,605
Ensembl chr 6:31,907,291...31,947,698
JBrowse link
G Hadhb hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of HADHB mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of HADHB mRNA CTD PMID:23783067 NCBI chr 6:31,873,404...31,907,557
Ensembl chr 6:31,873,404...31,907,835
JBrowse link
G Hdac1 histone deacetylase 1 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of HDAC1 mRNA CTD PMID:23783067 NCBI chr 5:147,138,328...147,165,387
Ensembl chr 5:147,138,156...147,165,387
JBrowse link
G Hdac5 histone deacetylase 5 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of HDAC5 mRNA CTD PMID:23783067 NCBI chr10:87,653,139...87,688,078
Ensembl chr10:87,652,656...87,694,244
JBrowse link
G Hgf hepatocyte growth factor multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of HGF mRNA CTD PMID:23783067 NCBI chr 4:19,628,902...19,700,467
Ensembl chr 4:19,632,267...19,700,851
JBrowse link
G Hras HRas proto-oncogene, GTPase increases expression ISO Aspartame results in increased expression of HRAS CTD PMID:17354619 NCBI chr 1:205,712,625...205,729,406
Ensembl chr 1:205,725,975...205,729,590
JBrowse link
G Hspg2 heparan sulfate proteoglycan 2 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of HSPG2 mRNA CTD PMID:23783067 NCBI chr 5:154,960,818...155,061,971
Ensembl chr 5:154,960,846...155,061,971
JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of IDH2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of IDH2 mRNA CTD PMID:23783067 NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:143,439,323...143,467,248
JBrowse link
G Il11 interleukin 11 decreases expression ISO Aspartame results in decreased expression of IL11 mRNA CTD PMID:31655124 NCBI chr 1:78,098,622...78,104,915
Ensembl chr 1:78,096,930...78,104,915
JBrowse link
G Il1b interleukin 1 beta increases expression ISO Aspartame results in increased expression of IL1B mRNA CTD PMID:31655124 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
JBrowse link
G Il3 interleukin 3 decreases expression ISO Aspartame results in decreased expression of IL3 mRNA CTD PMID:31655124 NCBI chr10:38,405,716...38,408,066
Ensembl chr10:38,906,460...38,908,810
JBrowse link
G Il6 interleukin 6 increases secretion ISO Aspartame results in increased secretion of IL6 protein CTD PMID:20837131 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
JBrowse link
G Immt inner membrane mitochondrial protein multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of IMMT mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of IMMT mRNA CTD PMID:23783067 NCBI chr 4:105,438,657...105,477,370
Ensembl chr 4:105,438,712...105,477,368
JBrowse link
G Ins2 insulin 2 increases expression
multiple interactions
ISO Aspartame results in increased expression of INS protein
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] results in increased expression of INS2 protein; Aspartame inhibits the reaction [Fats, Unsaturated results in increased expression of INS2 protein]
CTD PMID:1805284 PMID:23783067 NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:207,272,742...207,273,805
JBrowse link
G Kdr kinase insert domain receptor increases secretion ISO Aspartame results in increased secretion of KDR protein CTD PMID:20837131 NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,572,049...32,615,192
JBrowse link
G Lep leptin decreases expression
multiple interactions
EXP
ISO
Aspartame results in decreased expression of LEP protein
[Fats, Unsaturated co-treated with Aspartame] results in increased expression of LEP protein; [Sodium Glutamate co-treated with Aspartame] promotes the reaction [Fats, Unsaturated results in increased expression of LEP protein]
CTD PMID:11890951 PMID:23783067 NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:58,626,523...58,640,661
JBrowse link
G Lhb luteinizing hormone subunit beta decreases expression ISO Aspartame results in decreased expression of LHB protein CTD PMID:32951320 NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:105,037,457...105,038,445
JBrowse link
G Lipg lipase G, endothelial type multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of LIPG mRNA CTD PMID:23783067 NCBI chr18:70,790,077...70,811,259
Ensembl chr18:70,790,077...70,812,260
JBrowse link
G Lrp1 LDL receptor related protein 1 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of LRP1 mRNA CTD PMID:23783067 NCBI chr 7:65,265,639...65,346,196
Ensembl chr 7:65,265,639...65,346,196
JBrowse link
G Lrp2 LDL receptor related protein 2 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of LRP2 mRNA CTD PMID:23783067 NCBI chr 3:74,597,148...74,754,535
Ensembl chr 3:74,597,148...74,754,535
JBrowse link
G Lrp4 LDL receptor related protein 4 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of LRP4 mRNA CTD PMID:23783067 NCBI chr 3:97,885,373...97,939,366
Ensembl chr 3:97,885,400...97,939,370
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO Aspartame results in increased phosphorylation of MAPK1 protein CTD PMID:20837131 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO Aspartame results in increased phosphorylation of MAPK3 protein CTD PMID:20837131 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
JBrowse link
G Mcu mitochondrial calcium uniporter multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of MCU mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MCU mRNA CTD PMID:23783067 NCBI chr20:27,960,520...28,123,103
Ensembl chr20:27,961,327...28,123,103
JBrowse link
G Mdm2 MDM2 proto-oncogene multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MDM2 mRNA CTD PMID:23783067 NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:55,176,560...55,200,791
JBrowse link
G Med23 mediator complex subunit 23 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MED23 mRNA CTD PMID:23783067 NCBI chr 1:22,309,613...22,377,745
Ensembl chr 1:22,309,613...22,356,754
JBrowse link
G Mef2d myocyte enhancer factor 2D multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MEF2D mRNA CTD PMID:23783067 NCBI chr 2:173,606,054...173,635,620
Ensembl chr 2:175,903,959...175,930,760
JBrowse link
G Micos10 mitochondrial contact site and cristae organizing system subunit 10 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of MINOS1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MINOS1 mRNA CTD PMID:23783067 NCBI chr 5:151,341,124...151,367,403
Ensembl chr 5:156,624,357...156,650,633
JBrowse link
G Micu1 mitochondrial calcium uptake 1 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of MICU1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MICU1 mRNA CTD PMID:23783067 NCBI chr20:28,211,774...28,357,928
Ensembl chr20:28,211,691...28,359,919
JBrowse link
G Mrpl20 mitochondrial ribosomal protein L20 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of MRPL20 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MRPL20 mRNA CTD PMID:23783067 NCBI chr 5:166,408,962...166,413,492
Ensembl chr 5:171,691,198...171,695,728
JBrowse link
G Mrpl3 mitochondrial ribosomal protein L3 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of MRPL3 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MRPL3 mRNA CTD PMID:23783067 NCBI chr 8:105,670,184...105,693,544
Ensembl chr 8:114,548,970...114,573,996
JBrowse link
G Mrps12 mitochondrial ribosomal protein S12 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of MRPS12 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MRPS12 mRNA CTD PMID:23783067 NCBI chr 1:93,153,424...93,156,422
Ensembl chr 1:93,153,425...93,159,629
JBrowse link
G Mrps24 mitochondrial ribosomal protein S24 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of MRPS24 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MRPS24 mRNA CTD PMID:23783067 NCBI chr14:80,584,671...80,588,801 JBrowse link
G Mrps27 mitochondrial ribosomal protein S27 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of MRPS27 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MRPS27 mRNA CTD PMID:23783067 NCBI chr 2:32,474,178...32,542,741
Ensembl chr 2:32,473,965...32,542,738
JBrowse link
G Mrps7 mitochondrial ribosomal protein S7 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of MRPS7 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MRPS7 mRNA CTD PMID:23783067 NCBI chr10:101,342,642...101,345,790
Ensembl chr10:101,342,421...101,346,082
JBrowse link
G Mtfp1 mitochondrial fission process 1 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of MTFP1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MTFP1 mRNA CTD PMID:23783067 NCBI chr14:83,192,013...83,195,853
Ensembl chr14:83,192,021...83,195,927
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression ISO Aspartame results in increased expression of MYC
Aspartame results in increased expression of MYC protein
CTD PMID:17354619 PMID:33992720 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028
JBrowse link
G Ncor1 nuclear receptor co-repressor 1 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NCOR1 mRNA CTD PMID:23783067 NCBI chr10:47,498,852...47,641,612
Ensembl chr10:47,498,852...47,640,350
JBrowse link
G Ndufa12 NADH:ubiquinone oxidoreductase subunit A12 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFA12 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFA12 mRNA CTD PMID:23783067 NCBI chr 7:30,658,316...30,685,302
Ensembl chr 7:30,658,322...30,686,300
JBrowse link
G Ndufa5 NADH:ubiquinone oxidoreductase subunit A5 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFA5 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFA5 mRNA CTD PMID:23783067 NCBI chr 4:53,962,877...53,971,235
Ensembl chr 4:53,962,877...53,971,235
JBrowse link
G Ndufb10 NADH:ubiquinone oxidoreductase subunit B10 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFB10 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFB10 mRNA CTD PMID:23783067 NCBI chr10:14,253,805...14,255,966
Ensembl chr10:14,253,805...14,255,966
JBrowse link
G Ndufb2 NADH:ubiquinone oxidoreductase subunit B2 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFB2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFB2 mRNA CTD PMID:23783067 NCBI chr 4:69,334,307...69,341,394
Ensembl chr 4:69,334,307...69,340,136
Ensembl chr15:69,334,307...69,340,136
JBrowse link
G Ndufb6 NADH:ubiquinone oxidoreductase subunit B6 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFB6 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFB6 mRNA CTD PMID:23783067 NCBI chr 5:60,196,585...60,206,152
Ensembl chr 5:60,196,585...60,206,055
JBrowse link
G Ndufs1 NADH:ubiquinone oxidoreductase core subunit S1 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFS1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFS1 mRNA CTD PMID:23783067 NCBI chr 9:72,040,286...72,073,605
Ensembl chr 9:72,040,090...72,073,605
JBrowse link
G Ndufs6 NADH:ubiquinone oxidoreductase subunit S6 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFS6 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFS6 mRNA CTD PMID:23783067 NCBI chr 1:31,797,400...31,805,965
Ensembl chr 1:31,797,394...31,805,965
JBrowse link
G Ndufv1 NADH:ubiquinone oxidoreductase core subunit V1 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFV1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFV1 mRNA CTD PMID:23783067 NCBI chr 1:201,300,365...201,305,461
Ensembl chr 1:210,729,858...210,734,949
JBrowse link
G Nf1 neurofibromin 1 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NF1 mRNA CTD PMID:23783067 NCBI chr10:64,803,986...65,037,086
Ensembl chr10:64,804,266...65,034,946
JBrowse link
G Notch1 notch receptor 1 multiple interactions
affects localization
ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NOTCH1 mRNA
TAS1R1 protein affects the reaction [Aspartame affects the localization of NOTCH1 protein modified form]
CTD PMID:23783067 PMID:33992720 NCBI chr 3:29,676,040...29,721,613
Ensembl chr 3:29,676,171...29,721,613
JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NOX1 mRNA CTD PMID:23783067 NCBI chr  X:101,572,338...101,625,571
Ensembl chr  X:101,572,340...101,595,520
JBrowse link
G Nppb natriuretic peptide B decreases expression ISO Aspartame results in decreased expression of NPPB mRNA CTD PMID:31655124 NCBI chr 5:163,699,955...163,701,314
Ensembl chr 5:163,699,839...163,701,310
JBrowse link
G Npy neuropeptide Y decreases expression EXP Aspartame results in decreased expression of NPY protein CTD PMID:11890951 NCBI chr 4:80,212,111...80,219,310
Ensembl chr 4:80,212,111...80,219,310
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NR1I3 mRNA CTD PMID:23783067 NCBI chr13:86,165,327...86,170,362
Ensembl chr13:86,165,349...86,170,370
JBrowse link
G Onecut1 one cut homeobox 1 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ONECUT1 mRNA CTD PMID:23783067 NCBI chr 8:84,480,066...84,507,848
Ensembl chr 8:84,480,305...84,508,124
JBrowse link
G Pdha2 pyruvate dehydrogenase E1 subunit alpha 2 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of PDHA2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PDHA2 mRNA CTD PMID:23783067 NCBI chr 2:229,872,300...229,873,848
Ensembl chr 2:232,415,088...232,549,624
JBrowse link
G Pdhb pyruvate dehydrogenase E1 subunit beta multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of PDHB mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PDHB mRNA CTD PMID:23783067 NCBI chr15:16,752,561...16,758,503
Ensembl chr15:19,181,208...19,188,976
JBrowse link
G Pex1 peroxisomal biogenesis factor 1 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of PEX1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PEX1 mRNA CTD PMID:23783067 NCBI chr 4:30,519,950...30,558,953
Ensembl chr 4:31,470,845...31,513,811
JBrowse link
G Pex11a peroxisomal biogenesis factor 11 alpha multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of PEX11A mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PEX11A mRNA CTD PMID:23783067 NCBI chr 1:143,089,410...143,096,491
Ensembl chr 1:143,089,410...143,096,645
JBrowse link
G Pex13 peroxisomal biogenesis factor 13 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of PEX13 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PEX13 mRNA CTD PMID:23783067 NCBI chr14:97,602,829...97,621,233
Ensembl chr14:101,804,673...101,822,367
JBrowse link
G Pex5 peroxisomal biogenesis factor 5 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of PEX5 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PEX5 mRNA CTD PMID:23783067 NCBI chr 4:158,956,973...158,983,581
Ensembl chr 4:158,956,974...158,982,733
JBrowse link
G Pex7 peroxisomal biogenesis factor 7 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of PEX7 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PEX7 mRNA CTD PMID:23783067 NCBI chr 1:14,582,698...14,646,686
Ensembl chr 1:16,402,320...16,466,366
JBrowse link
G Pfkfb2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of PFKFB2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PFKFB2 mRNA CTD PMID:23783067 NCBI chr13:44,683,499...44,727,135
Ensembl chr13:44,699,744...44,726,971
JBrowse link
G Pfkfb4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of PFKFB4 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PFKFB4 mRNA CTD PMID:23783067 NCBI chr 8:118,522,371...118,565,478
Ensembl chr 8:118,522,365...118,565,468
JBrowse link
G Pld2 phospholipase D2 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PLD2 mRNA CTD PMID:23783067 NCBI chr10:55,754,957...55,772,819
Ensembl chr10:55,754,988...55,771,435
JBrowse link
G Plg plasminogen decreases expression ISO Aspartame results in decreased expression of PLG mRNA CTD PMID:31655124 NCBI chr 1:50,872,927...50,915,406
Ensembl chr 1:50,872,926...50,917,320
JBrowse link
G Plxnd1 plexin D1 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PLXND1 mRNA CTD PMID:23783067 NCBI chr 4:150,675,377...150,715,706
Ensembl chr 4:150,675,377...150,715,566
JBrowse link
G Polg DNA polymerase gamma, catalytic subunit multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of POLG mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of POLG mRNA CTD PMID:23783067 NCBI chr 1:142,792,119...142,808,933
Ensembl chr 1:142,792,119...142,808,838
JBrowse link
G Pomc proopiomelanocortin increases expression ISO Aspartame results in increased expression of POMC protein alternative form CTD PMID:1805284 NCBI chr 6:32,659,137...32,665,175
Ensembl chr 6:32,659,346...32,665,173
JBrowse link
G Pou5f1 POU class 5 homeobox 1 affects localization ISO Aspartame affects the localization of POU5F1 protein CTD PMID:33992720 NCBI chr20:3,227,836...3,232,598
Ensembl chr20:3,227,837...3,232,598
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of PPARA mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PPARA mRNA CTD PMID:23783067 NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PPARD mRNA CTD PMID:23783067 NCBI chr20:6,300,527...6,365,707
Ensembl chr20:6,352,183...6,365,707
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PPARG mRNA CTD PMID:23783067 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of PPARGC1A mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PPARGC1A mRNA CTD PMID:23783067 NCBI chr14:63,073,505...63,729,215
Ensembl chr14:63,273,189...63,729,213
JBrowse link
G Prdx5 peroxiredoxin 5 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of PRDX5 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PRDX5 mRNA CTD PMID:23783067 NCBI chr 1:213,529,042...213,532,787
Ensembl chr 1:213,529,035...213,533,020
JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ROCK1 mRNA CTD PMID:23783067 NCBI chr18:1,387,360...1,509,218
Ensembl chr18:1,387,360...1,509,147
JBrowse link
G S100a13 S100 calcium binding protein A13 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of S100A13 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of S100A13 mRNA CTD PMID:23783067 NCBI chr 2:178,297,020...178,303,514
Ensembl chr 2:178,296,917...178,303,507
JBrowse link
G S100a8 S100 calcium binding protein A8 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of S100A8 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of S100A8 mRNA CTD PMID:23783067 NCBI chr 2:178,464,095...178,465,223
Ensembl chr 2:178,464,702...178,465,221
JBrowse link
G Sdhb succinate dehydrogenase complex iron sulfur subunit B multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of SDHB mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SDHB mRNA CTD PMID:23783067 NCBI chr 5:158,547,775...158,568,589
Ensembl chr 5:158,547,689...158,569,667
JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SIRT1 mRNA CTD PMID:23783067 NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000
JBrowse link
G Sirt2 sirtuin 2 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SIRT2 mRNA CTD PMID:23783067 NCBI chr 1:93,181,472...93,204,499
Ensembl chr 1:93,181,224...93,204,499
JBrowse link
G Slc15a1 solute carrier family 15 member 1 decreases activity ISO Aspartame results in decreased activity of SLC15A1 protein CTD PMID:15846457 NCBI chr15:104,944,461...104,991,316
Ensembl chr15:104,944,463...104,989,369
JBrowse link
G Slc4a2 solute carrier family 4 member 2 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SLC4A2 mRNA CTD PMID:23783067 NCBI chr 4:11,628,860...11,646,961
Ensembl chr 4:11,628,862...11,645,402
JBrowse link
G Slc8a1 solute carrier family 8 member A1 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of SLC8A1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SLC8A1 mRNA CTD PMID:23783067 NCBI chr 6:18,975,498...19,299,704
Ensembl chr 6:18,946,798...19,287,964
JBrowse link
G Sox2 SRY-box transcription factor 2 affects localization ISO Aspartame affects the localization of SOX2 protein CTD PMID:33992720 NCBI chr 2:119,465,131...119,467,542
Ensembl chr 2:119,454,541...119,496,350
JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SREBF2 mRNA CTD PMID:23783067 NCBI chr 7:115,542,774...115,600,945
Ensembl chr 7:115,543,290...115,600,943
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of STAT3 mRNA CTD PMID:23783067 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359
JBrowse link
G Surf1 SURF1, cytochrome c oxidase assembly factor multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of SURF1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SURF1 mRNA CTD PMID:23783067 NCBI chr 3:30,639,868...30,642,759 JBrowse link
G Tas1r1 taste 1 receptor member 1 increases expression
multiple interactions
ISO Aspartame results in increased expression of TAS1R1 protein
Aspartame promotes the reaction [TAS1R3 protein binds to TAS1R1 protein]; TAS1R1 protein affects the reaction [Aspartame affects the localization of CDKN1A protein]; TAS1R1 protein affects the reaction [Aspartame affects the localization of GLI1 protein]; TAS1R1 protein affects the reaction [Aspartame affects the localization of NOTCH1 protein modified form]
CTD PMID:33992720 NCBI chr 5:162,533,838...162,546,408
Ensembl chr 5:167,816,569...167,828,489
JBrowse link
G Tas1r2 taste 1 receptor member 2 multiple interactions
affects binding
ISO Aspartame binds to and results in increased activity of TAS1R2 protein; Aspartame promotes the reaction [TAS1R3 protein binds to TAS1R2 protein]; lactisole inhibits the reaction [Aspartame results in increased activity of [TAS1R3 protein binds to TAS1R2 protein]]
Aspartame binds to [TAS1R2 protein binds to TAS1R3 protein]; Aspartame binds to TAS1R2 protein
CTD PMID:15353592 PMID:17168764 PMID:17935609 PMID:20173092 PMID:33992720 NCBI chr 5:157,192,799...157,208,937
Ensembl chr 5:157,192,799...157,208,937
JBrowse link
G Tas1r3 taste 1 receptor member 3 affects binding
decreases expression
multiple interactions
ISO Aspartame binds to [TAS1R2 protein binds to TAS1R3 protein]
Aspartame results in decreased expression of TAS1R3 protein
Aspartame promotes the reaction [TAS1R3 protein binds to TAS1R1 protein]; Aspartame promotes the reaction [TAS1R3 protein binds to TAS1R2 protein]; lactisole inhibits the reaction [Aspartame results in increased activity of [TAS1R3 protein binds to TAS1R2 protein]]
CTD PMID:17168764 PMID:17935609 PMID:33992720 NCBI chr 5:166,468,703...166,472,759
Ensembl chr 5:171,750,937...171,754,993
JBrowse link
G Tfam transcription factor A, mitochondrial multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of TFAM mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of TFAM mRNA CTD PMID:23783067 NCBI chr20:17,355,373...17,367,422
Ensembl chr20:17,355,363...17,369,877
JBrowse link
G Thbs1 thrombospondin 1 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of THBS1 mRNA CTD PMID:23783067 NCBI chr 3:125,510,250...125,525,402
Ensembl chr 3:125,510,250...125,525,402
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] results in increased expression of TNF protein; [Sodium Glutamate co-treated with Aspartame] promotes the reaction [Fats, Unsaturated results in increased expression of TNF protein] CTD PMID:23783067 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions
ISO Aspartame results in increased expression of TRP53; Aspartame results in increased expression of TRP53 mRNA
[Fats, Unsaturated co-treated with Aspartame] affects the expression of TRP53 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of TRP53 mRNA
CTD PMID:17354619 PMID:23783067 PMID:32951320 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 increases activity ISO Aspartame results in increased activity of TRPV1 protein CTD PMID:17567713 PMID:18804451 NCBI chr10:58,349,936...58,375,021
Ensembl chr10:58,340,223...58,375,021
JBrowse link
G Tufm Tu translation elongation factor, mitochondrial multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of TUFM mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of TUFM mRNA CTD PMID:23783067 NCBI chr 1:190,504,373...190,507,980
Ensembl chr 1:190,504,373...190,508,952
JBrowse link
G Ucp2 uncoupling protein 2 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of UCP2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of UCP2 mRNA CTD PMID:23783067 NCBI chr 1:164,251,373...164,257,742
Ensembl chr 1:164,251,373...164,257,743
JBrowse link
G Uqcr11 ubiquinol-cytochrome c reductase, complex III subunit XI multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of UQCR11 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of UQCR11 mRNA CTD PMID:23783067 NCBI chr 7:9,955,717...9,960,432
Ensembl chr 7:9,955,764...9,959,047
JBrowse link
G Vegfa vascular endothelial growth factor A increases secretion ISO Aspartame results in increased secretion of VEGFA protein CTD PMID:20837131 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194
JBrowse link
G Vim vimentin increases expression ISO Aspartame results in increased expression of VIM protein CTD PMID:33992720 NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746
JBrowse link
G Xdh xanthine dehydrogenase multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of XDH mRNA CTD PMID:23783067 NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:27,282,057...27,344,350
JBrowse link
goralatide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme increases expression
decreases expression
multiple interactions
ISO goralatide results in increased expression of ACE mRNA
goralatide results in decreased expression of ACE mRNA
[BDKRB1 protein affects the activity of ACE protein] which affects the hydrolysis of goralatide; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of ACE mRNA]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of ACE protein]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in decreased expression of ACE2 mRNA]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in decreased expression of CDH1 protein]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in increased expression of ACE mRNA]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in increased expression of ACE protein]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in increased expression of COL3A1 protein]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in increased expression of VIM protein]]; goralatide affects the reaction [ACE2 protein affects the reaction [Silicon Dioxide results in increased expression of ACE mRNA]]; goralatide inhibits the reaction [AGT protein results in increased expression of ACE mRNA]; goralatide inhibits the reaction [AGT protein results in increased expression of ACE protein]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of ACE mRNA]
CTD PMID:20096676 PMID:33007385 NCBI chr10:91,410,129...91,430,246
Ensembl chr10:91,409,819...91,430,942
JBrowse link
G Ace2 angiotensin converting enzyme 2 multiple interactions ISO ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in decreased expression of MAS1 protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of ACE mRNA]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of ACE protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of AGT protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in decreased expression of ACE2 mRNA]]; goralatide affects the reaction [ACE2 protein affects the reaction [AGT protein results in decreased abundance of angiotensin I (1-7)]]; goralatide affects the reaction [ACE2 protein affects the reaction [Silicon Dioxide results in decreased expression of ACE2 mRNA]]; goralatide affects the reaction [ACE2 protein affects the reaction [Silicon Dioxide results in decreased expression of ACE2 protein]]; goralatide affects the reaction [ACE2 protein affects the reaction [Silicon Dioxide results in increased expression of ACE mRNA]]; goralatide affects the reaction [ACE2 protein affects the reaction [Silicon Dioxide results in increased expression of AGT protein]]; goralatide inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]; goralatide inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]; goralatide inhibits the reaction [Silicon Dioxide results in decreased expression of ACE2 mRNA]; goralatide inhibits the reaction [Silicon Dioxide results in decreased expression of ACE2 protein] CTD PMID:33007385 NCBI chr  X:33,925,458...33,972,851
Ensembl chr  X:33,925,458...33,971,596
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO
EXP
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; goralatide inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]
[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]
goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]]; goralatide inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]
CTD PMID:31181250 PMID:33007385 NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503
JBrowse link
G Agt angiotensinogen multiple interactions ISO ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in decreased expression of MAS1 protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of ACE mRNA]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of ACE protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of AGT protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]]; goralatide affects the reaction [ACE2 protein affects the reaction [AGT protein results in decreased abundance of angiotensin I (1-7)]]; goralatide affects the reaction [ACE2 protein affects the reaction [Silicon Dioxide results in increased expression of AGT protein]]; goralatide inhibits the reaction [AGT protein results in decreased abundance of angiotensin I (1-7)]; goralatide inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]; goralatide inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]; goralatide inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]; goralatide inhibits the reaction [AGT protein results in decreased expression of MAS1 protein]; goralatide inhibits the reaction [AGT protein results in increased expression of ACE mRNA]; goralatide inhibits the reaction [AGT protein results in increased expression of ACE protein]; goralatide inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; goralatide inhibits the reaction [AGT protein results in increased expression of AGT protein]; goralatide inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]; goralatide inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]; goralatide inhibits the reaction [AGT protein results in increased expression of VIM protein]; goralatide inhibits the reaction [Silicon Dioxide results in decreased expression of AGT protein alternative form]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of AGT protein]
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in decreased expression of GLI3 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in decreased expression of PTCH1 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of GLI1 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of GLI2 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of SHH protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of SMO protein]; goralatide inhibits the reaction [AGT protein results in decreased expression of GLI3 protein]; goralatide inhibits the reaction [AGT protein results in decreased expression of PTCH1 protein]; goralatide inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; goralatide inhibits the reaction [AGT protein results in increased expression of GLI1 protein]; goralatide inhibits the reaction [AGT protein results in increased expression of GLI2 protein]; goralatide inhibits the reaction [AGT protein results in increased expression of SHH protein]; goralatide inhibits the reaction [AGT protein results in increased expression of SMO protein]
CTD PMID:31181250 PMID:33007385 NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944
JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions ISO ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]]; goralatide inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of AGTR1 protein] CTD PMID:33007385 NCBI chr17:34,383,397...34,435,523
Ensembl chr17:34,381,467...34,435,660
JBrowse link
G Bdkrb1 bradykinin receptor B1 affects abundance
multiple interactions
ISO BDKRB1 protein affects the abundance of goralatide
[BDKRB1 protein affects the activity of ACE protein] which affects the hydrolysis of goralatide
CTD PMID:20096676 NCBI chr 6:130,275,631...130,284,968
Ensembl chr 6:130,275,478...130,280,973
JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in decreased expression of CDH1 protein]]; goralatide inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]; goralatide inhibits the reaction [Silicon Dioxide results in decreased expression of CDH1 protein] CTD PMID:33007385 NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565
JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions ISO ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in increased expression of COL3A1 protein]]; goralatide inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of COL3A1 protein] CTD PMID:33007385 NCBI chr 9:54,866,646...54,902,578
Ensembl chr 9:54,866,632...54,903,232
JBrowse link
G Gli1 GLI family zinc finger 1 multiple interactions ISO
EXP
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of GLI1 protein]; goralatide inhibits the reaction [AGT protein results in increased expression of GLI1 protein]
[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of GLI1 protein]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of GLI1 protein]
CTD PMID:31181250 NCBI chr 7:65,042,237...65,054,888
Ensembl chr 7:65,042,237...65,054,540
JBrowse link
G Gli2 GLI family zinc finger 2 multiple interactions ISO
EXP
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of GLI2 protein]; goralatide inhibits the reaction [AGT protein results in increased expression of GLI2 protein]
[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of GLI2 protein]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of GLI2 protein]
CTD PMID:31181250 NCBI chr13:32,499,678...32,716,418
Ensembl chr13:32,499,678...32,716,418
JBrowse link
G Gli3 GLI family zinc finger 3 multiple interactions EXP
ISO
[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in decreased expression of GLI3 protein]; goralatide inhibits the reaction [Silicon Dioxide results in decreased expression of GLI3 protein]
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in decreased expression of GLI3 protein]; goralatide inhibits the reaction [AGT protein results in decreased expression of GLI3 protein]
CTD PMID:31181250 NCBI chr17:54,134,064...54,405,198
Ensembl chr17:54,134,064...54,405,198
JBrowse link
G Mas1 MAS1 proto-oncogene, G protein-coupled receptor multiple interactions ISO ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in decreased expression of MAS1 protein]]; goralatide inhibits the reaction [AGT protein results in decreased expression of MAS1 protein]; goralatide inhibits the reaction [Silicon Dioxide results in decreased expression of MAS1 protein] CTD PMID:33007385 NCBI chr 1:50,428,064...50,459,537
Ensembl chr 1:50,425,257...50,500,561
JBrowse link
G Ptch1 patched 1 multiple interactions EXP
ISO
[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in decreased expression of PTCH1 protein]; goralatide inhibits the reaction [Silicon Dioxide results in decreased expression of PTCH1 protein]
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in decreased expression of PTCH1 protein]; goralatide inhibits the reaction [AGT protein results in decreased expression of PTCH1 protein]
CTD PMID:31181250 NCBI chr17:1,548,449...1,613,461
Ensembl chr17:1,548,449...1,613,461
JBrowse link
G Shh sonic hedgehog signaling molecule multiple interactions ISO
EXP
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of SHH protein]; goralatide inhibits the reaction [AGT protein results in increased expression of SHH protein]
[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of SHH protein]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of SHH protein]
CTD PMID:31181250 NCBI chr 4:7,687,872...7,697,025
Ensembl chr 4:7,687,846...7,697,901
JBrowse link
G Smo smoothened, frizzled class receptor multiple interactions EXP
ISO
[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of SMO protein]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of SMO protein]
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of SMO protein]; goralatide inhibits the reaction [AGT protein results in increased expression of SMO protein]
CTD PMID:31181250 NCBI chr 4:59,311,084...59,341,280
Ensembl chr 4:59,311,041...59,341,281
JBrowse link
G Vim vimentin multiple interactions ISO goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in increased expression of VIM protein]]; goralatide inhibits the reaction [AGT protein results in increased expression of VIM protein]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of VIM protein] CTD PMID:33007385 NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      biological role 20818
        molecular messenger 19442
          neurotransmitter 11787
            L-aspartic acid 183
              Ac-Tyr-Val-Ala-Asp-chloromethylketone 0
              Ala-Ala-Asp 0
              Ala-Ala-Asp-Asp 0
              Ala-Asn-Asp-Pro 0
              Ala-Asp-Gly 0
              Ala-Asp-Pro 0
              Ala-Asp-Ser 0
              Ala-Leu-Asp-Asp 0
              Ala-Leu-Asp-Gly 0
              Ala-Leu-Leu-Asp 0
              Ala-Met-Asp-Tyr 0
              Ala-Trp-Asn-Asp 0
              Ala-Val-Asp-His 0
              Ala-Val-Asp-Pro 0
              Ala-Val-Asp-Ser 0
              Ala-Val-Asp-Tyr 0
              Arg-Asp-Asp 0
              Arg-Asp-Gln-Ser 0
              Arg-Thr-Thr-Asp 0
              Asn-Asp 0
              Asn-Leu-Asp-Asp 0
              Asn-Leu-Phe-Asp 0
              Asn-Trp-Asp-Ser 0
              Asp-Arg 0
              Asp-Asp 0
              Asp-Gln-Arg 0
              Asp-Gln-Ser 0
              Asp-Gly 0
              Asp-Gly-Pro 0
              Asp-His 0
              Asp-Leu-Asp-Gln 0
              Asp-Leu-Leu-Gln 0
              Asp-Leu-Leu-Ser 0
              Asp-Leu-Phe-Val 0
              Asp-Leu-Thr-Asp 0
              Asp-Leu-Thr-Ser 0
              Asp-Lys 0
              Asp-Lys-Ile 0
              Asp-Met 0
              Asp-Met-Met-Cys 0
              Asp-Met-Thr-Pro 0
              Asp-Phe-Asp-Gln 0
              Asp-Phe-Val-Tyr 0
              Asp-Phe-Val-Val 0
              Asp-Pro-Ser-Ser 0
              Asp-Ser 0
              Asp-Thr 0
              Asp-Trp-Trp-Val 0
              Asp-Tyr 0
              Asp-Val-Gly-Pro 0
              Asp-Val-Pro-Pro 0
              Asp-Val-Val-Val 0
              Cys-Asp-Gly 0
              Glu-Asp 0
              Glu-Asp-Arg 0
              Glu-Asp-Asp 0
              Glu-Asp-Gln-Gln 0
              Glu-Asp-Ile 0
              Glu-Trp-Asp-Arg 0
              Ile-Asp 0
              L-alpha-aspartyl group 0
              L-aspartic acid derivative + 1
              L-aspartic acid residue + 0
              L-aspartic acid-d7 0
              L-asparto group 0
              L-aspartoyl group 0
              L-beta-aspartyl group 0
              Leu-Ala-Asp 0
              Leu-Asp-Gln 0
              Leu-Asp-Gly 0
              Leu-Asp-Ser 0
              Leu-Asp-Tyr 0
              Leu-Leu-Asp 0
              Leu-Lys-Asp 0
              Leu-Phe-Asp 0
              Leu-Thr-Asp 0
              Leu-Val-Asp 0
              Lys-Asp 0
              Lys-Asp-Tyr 0
              Met-Ala-Asp 0
              N-acetyl-L-seryl-L-aspartic acid 0
              Phe-Ala-Asp 0
              Phe-Asp 0
              Phe-Asp-Cys 0
              Phe-Phe-Asp 0
              Phe-Tyr-Asp 0
              Phe-Val-Asp 0
              Ser-Asp-Lys 0
              Ser-Asp-Lys-Pro + 16
              Thr-Ala-Asp 0
              Thr-Asp-Gly 0
              Thr-Thr-Asp 0
              Thr-Trp-Asp 0
              Trp-Ala-Asp 0
              Trp-Asp-Ser 0
              Tyr-Asp 0
              alpha-Asp-Ile 0
              aspartame 169
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    main group molecular entity 20781
                      s-block molecular entity 20574
                        hydrogen molecular entity 20558
                          hydrides 19693
                            inorganic hydride 18602
                              pnictogen hydride 18589
                                nitrogen hydride 18502
                                  azane 18262
                                    ammonia 18261
                                      organic amino compound 18261
                                        amino acid 16340
                                          alpha-amino acid 14255
                                            L-alpha-amino acid 12393
                                              aspartate family amino acid 3711
                                                L-aspartic acid 183
                                                  Ac-Tyr-Val-Ala-Asp-chloromethylketone 0
                                                  Ala-Ala-Asp 0
                                                  Ala-Ala-Asp-Asp 0
                                                  Ala-Asn-Asp-Pro 0
                                                  Ala-Asp-Gly 0
                                                  Ala-Asp-Pro 0
                                                  Ala-Asp-Ser 0
                                                  Ala-Leu-Asp-Asp 0
                                                  Ala-Leu-Asp-Gly 0
                                                  Ala-Leu-Leu-Asp 0
                                                  Ala-Met-Asp-Tyr 0
                                                  Ala-Trp-Asn-Asp 0
                                                  Ala-Val-Asp-His 0
                                                  Ala-Val-Asp-Pro 0
                                                  Ala-Val-Asp-Ser 0
                                                  Ala-Val-Asp-Tyr 0
                                                  Arg-Asp-Asp 0
                                                  Arg-Asp-Gln-Ser 0
                                                  Arg-Thr-Thr-Asp 0
                                                  Asn-Asp 0
                                                  Asn-Leu-Asp-Asp 0
                                                  Asn-Leu-Phe-Asp 0
                                                  Asn-Trp-Asp-Ser 0
                                                  Asp-Arg 0
                                                  Asp-Asp 0
                                                  Asp-Gln-Arg 0
                                                  Asp-Gln-Ser 0
                                                  Asp-Gly 0
                                                  Asp-Gly-Pro 0
                                                  Asp-His 0
                                                  Asp-Leu-Asp-Gln 0
                                                  Asp-Leu-Leu-Gln 0
                                                  Asp-Leu-Leu-Ser 0
                                                  Asp-Leu-Phe-Val 0
                                                  Asp-Leu-Thr-Asp 0
                                                  Asp-Leu-Thr-Ser 0
                                                  Asp-Lys 0
                                                  Asp-Lys-Ile 0
                                                  Asp-Met 0
                                                  Asp-Met-Met-Cys 0
                                                  Asp-Met-Thr-Pro 0
                                                  Asp-Phe-Asp-Gln 0
                                                  Asp-Phe-Val-Tyr 0
                                                  Asp-Phe-Val-Val 0
                                                  Asp-Pro-Ser-Ser 0
                                                  Asp-Ser 0
                                                  Asp-Thr 0
                                                  Asp-Trp-Trp-Val 0
                                                  Asp-Tyr 0
                                                  Asp-Val-Gly-Pro 0
                                                  Asp-Val-Pro-Pro 0
                                                  Asp-Val-Val-Val 0
                                                  Cys-Asp-Gly 0
                                                  Glu-Asp 0
                                                  Glu-Asp-Arg 0
                                                  Glu-Asp-Asp 0
                                                  Glu-Asp-Gln-Gln 0
                                                  Glu-Asp-Ile 0
                                                  Glu-Trp-Asp-Arg 0
                                                  Ile-Asp 0
                                                  L-alpha-aspartyl group 0
                                                  L-aspartic acid derivative + 1
                                                  L-aspartic acid residue + 0
                                                  L-aspartic acid-d7 0
                                                  L-asparto group 0
                                                  L-aspartoyl group 0
                                                  L-beta-aspartyl group 0
                                                  Leu-Ala-Asp 0
                                                  Leu-Asp-Gln 0
                                                  Leu-Asp-Gly 0
                                                  Leu-Asp-Ser 0
                                                  Leu-Asp-Tyr 0
                                                  Leu-Leu-Asp 0
                                                  Leu-Lys-Asp 0
                                                  Leu-Phe-Asp 0
                                                  Leu-Thr-Asp 0
                                                  Leu-Val-Asp 0
                                                  Lys-Asp 0
                                                  Lys-Asp-Tyr 0
                                                  Met-Ala-Asp 0
                                                  N-acetyl-L-seryl-L-aspartic acid 0
                                                  Phe-Ala-Asp 0
                                                  Phe-Asp 0
                                                  Phe-Asp-Cys 0
                                                  Phe-Phe-Asp 0
                                                  Phe-Tyr-Asp 0
                                                  Phe-Val-Asp 0
                                                  Ser-Asp-Lys 0
                                                  Ser-Asp-Lys-Pro + 16
                                                  Thr-Ala-Asp 0
                                                  Thr-Asp-Gly 0
                                                  Thr-Thr-Asp 0
                                                  Thr-Trp-Asp 0
                                                  Trp-Ala-Asp 0
                                                  Trp-Asp-Ser 0
                                                  Tyr-Asp 0
                                                  alpha-Asp-Ile 0
                                                  aspartame 169
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