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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:dinitrogen oxide
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Accession:CHEBI:17045 term browser browse the term
Definition:A nitrogen oxide consisting of linear unsymmetrical molecules with formula N2O. While it is the most used gaseous anaesthetic in the world, its major commercial use, due to its solubility under pressure in vegetable fats combined with its non-toxicity in low concentrations, is as an aerosol spray propellant and aerating agent for canisters of 'whipped' cream.
Synonyms:exact_synonym: oxidodinitrogen(N--N)
 related_synonym: Dinitrogen monoxide;   Distickstoffmonoxid;   E942;   Formula=N2O;   InChI=1S/N2O/c1-2-3;   InChIKey=GQPLMRYTRLFLPF-UHFFFAOYSA-N;   Lachgas;   N2O;   NNO;   R-744A;   SMILES=[O-][N+]#N;   Stickstoff(I)-oxid;   diazyne 1-oxide;   factitious air;   gaz hilarant;   laughing gas;   nitrogen protoxide;   nitrogenium oxydulatum;   nitrous oxide;   oxyde nitreux;   protoxyde d'azote
 alt_id: CHEBI:14661;   CHEBI:25568;   CHEBI:44250;   CHEBI:7598
 xref: CAS:10024-97-2;   Drug_Central:4238;   Gmelin:2153410;   KEGG:C00887;   KEGG:D00102
 xref_mesh: MESH:D009609
 xref: PDBeChem:N2O;   PMID:11159233;   PMID:11811748;   PMID:15316643;   PMID:15644008;   PMID:16179535;   PMID:17093360;   PMID:18992971;   PMID:19910265;   PMID:21622873;   PMID:23643142;   PMID:7880215;   Reaxys:8137358;   UM-BBD_compID:c0650;   Wikipedia:Nitrous_oxide


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dinitrogen oxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cntf ciliary neurotrophic factor multiple interactions
decreases activity		 ISO
EXP		 Nitrous Oxide inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT1 protein]; Nitrous Oxide inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT3 protein]
Nitrous Oxide results in decreased activity of CNTF protein
Nitrous Oxide inhibits the reaction [CNTF protein results in increased activity of STAT3 protein]		 CTD PMID:15748169 NCBI chr19:12,740,892...12,742,996
Ensembl chr19:12,741,024...12,742,996 		JBrowse link
G Gabra4 gamma-aminobutyric acid type A receptor subunit alpha 4 multiple interactions EXP [Isoflurane co-treated with Nitrous Oxide] affects the expression of GABRA4 mRNA CTD PMID:16733821 NCBI chr 5:71,727,077...71,815,651
Ensembl chr 5:71,727,092...71,815,651 		JBrowse link
G Grin2a glutamate receptor, ionotropic, NMDA2A (epsilon 1) multiple interactions EXP GRIN2A protein affects the susceptibility to [Nitrous Oxide co-treated with sevoflurane] CTD PMID:15731593 NCBI chr16:9,385,765...9,813,744
Ensembl chr16:9,385,762...9,813,424 		JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase decreases activity ISO Nitrous Oxide results in decreased activity of MTR protein CTD PMID:18472229 NCBI chr13:12,196,217...12,273,090
Ensembl chr13:12,197,598...12,272,999 		JBrowse link
G Pla2g7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) affects expression ISO Nitrous Oxide affects the expression of PLA2G7 CTD PMID:21356620 NCBI chr17:43,879,009...43,923,093
Ensembl chr17:43,878,989...43,923,092 		JBrowse link
G Pomc pro-opiomelanocortin-alpha increases secretion ISO Nitrous Oxide results in increased secretion of POMC protein CTD PMID:2846107 NCBI chr12:4,004,945...4,010,643
Ensembl chr12:4,004,951...4,010,642 		JBrowse link
G Ren2 renin 2 tandem duplication of Ren1 affects abundance EXP REN2 protein affects the abundance of Nitrous Oxide CTD PMID:12512695
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO Nitrous Oxide inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT1 protein] CTD PMID:15748169 NCBI chr 1:52,158,588...52,201,024
Ensembl chr 1:52,158,599...52,201,024 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions EXP
ISO		 Nitrous Oxide inhibits the reaction [CNTF protein results in increased activity of STAT3 protein]
Nitrous Oxide inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT3 protein]		 CTD PMID:15748169 NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22289
    role 22274
      application 21889
        refrigerant 19232
          dinitrogen oxide 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 22289
    subatomic particle 22284
      composite particle 22284
        hadron 22284
          baryon 22284
            nucleon 22284
              atomic nucleus 22284
                atom 22284
                  main group element atom 22164
                    p-block element atom 22164
                      chalcogen 21498
                        oxygen atom 21476
                          oxygen molecular entity 21476
                            oxide 13495
                              inorganic oxide 8067
                                nitrogen oxide 439
                                  dinitrogen oxide 9
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