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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:dinitrogen oxide
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Accession:CHEBI:17045 term browser browse the term
Definition:A nitrogen oxide consisting of linear unsymmetrical molecules with formula N2O. While it is the most used gaseous anaesthetic in the world, its major commercial use, due to its solubility under pressure in vegetable fats combined with its non-toxicity in low concentrations, is as an aerosol spray propellant and aerating agent for canisters of 'whipped' cream.
Synonyms:exact_synonym: oxidodinitrogen(N--N)
 related_synonym: Dinitrogen monoxide;   Distickstoffmonoxid;   E942;   Formula=N2O;   InChI=1S/N2O/c1-2-3;   InChIKey=GQPLMRYTRLFLPF-UHFFFAOYSA-N;   Lachgas;   N2O;   NNO;   R-744A;   SMILES=[O-][N+]#N;   Stickstoff(I)-oxid;   diazyne 1-oxide;   factitious air;   gaz hilarant;   laughing gas;   nitrogen protoxide;   nitrogenium oxydulatum;   nitrous oxide;   oxyde nitreux;   protoxyde d'azote
 alt_id: CHEBI:14661;   CHEBI:25568;   CHEBI:44250;   CHEBI:7598
 xref: CAS:10024-97-2;   Drug_Central:4238;   Gmelin:2153410;   KEGG:C00887;   KEGG:D00102
 xref_mesh: MESH:D009609
 xref: PDBeChem:N2O;   PMID:11159233;   PMID:11811748;   PMID:15316643;   PMID:15644008;   PMID:16179535;   PMID:17093360;   PMID:18992971;   PMID:19910265;   PMID:21622873;   PMID:23643142;   PMID:7880215;   Reaxys:8137358;   UM-BBD_compID:c0650;   Wikipedia:Nitrous_oxide


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dinitrogen oxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CNTF ciliary neurotrophic factor multiple interactions
decreases activity		 EXP
ISO		 Nitrous Oxide inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT1 protein]; Nitrous Oxide inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT3 protein]
Nitrous Oxide results in decreased activity of CNTF protein
Nitrous Oxide inhibits the reaction [CNTF protein results in increased activity of STAT3 protein]		 CTD PMID:15748169 NCBI chr11:58,622,665...58,625,733
Ensembl chr11:58,622,665...58,625,733 		JBrowse link
G GABRA4 gamma-aminobutyric acid type A receptor subunit alpha4 multiple interactions ISO [Isoflurane co-treated with Nitrous Oxide] affects the expression of GABRA4 mRNA CTD PMID:16733821 NCBI chr 4:46,918,900...46,993,581
Ensembl chr 4:46,918,900...46,993,581 		JBrowse link
G GRIN2A glutamate ionotropic receptor NMDA type subunit 2A multiple interactions ISO GRIN2A protein affects the susceptibility to [Nitrous Oxide co-treated with sevoflurane] CTD PMID:15731593 NCBI chr16:9,753,404...10,182,908
Ensembl chr16:9,753,404...10,183,337 		JBrowse link
G MTR 5-methyltetrahydrofolate-homocysteine methyltransferase decreases activity EXP Nitrous Oxide results in decreased activity of MTR protein CTD PMID:18472229 NCBI chr 1:236,795,281...236,903,981
Ensembl chr 1:236,795,260...236,921,278 		JBrowse link
G PLA2G7 phospholipase A2 group VII affects expression EXP Nitrous Oxide affects the expression of PLA2G7 CTD PMID:21356620 NCBI chr 6:46,704,201...46,735,721
Ensembl chr 6:46,704,201...46,735,693 		JBrowse link
G POMC proopiomelanocortin increases secretion ISO Nitrous Oxide results in increased secretion of POMC protein CTD PMID:2846107 NCBI chr 2:25,160,860...25,168,580
Ensembl chr 2:25,160,853...25,168,903 		JBrowse link
G STAT1 signal transducer and activator of transcription 1 multiple interactions EXP Nitrous Oxide inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT1 protein] CTD PMID:15748169 NCBI chr 2:190,969,149...191,014,171
Ensembl chr 2:190,908,460...191,020,960 		JBrowse link
G STAT3 signal transducer and activator of transcription 3 multiple interactions ISO
EXP		 Nitrous Oxide inhibits the reaction [CNTF protein results in increased activity of STAT3 protein]
Nitrous Oxide inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT3 protein]		 CTD PMID:15748169 NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,568 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26496
    role 26318
      application 25582
        refrigerant 20365
          dinitrogen oxide 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 26496
    subatomic particle 26472
      composite particle 26472
        hadron 26472
          baryon 26472
            nucleon 26472
              atomic nucleus 26472
                atom 26472
                  main group element atom 26209
                    p-block element atom 26209
                      chalcogen 25117
                        oxygen atom 24924
                          oxygen molecular entity 24924
                            oxide 13901
                              inorganic oxide 8467
                                nitrogen oxide 438
                                  dinitrogen oxide 8
paths to the root