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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:biliverdin
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Accession:CHEBI:17033 term browser browse the term
Definition:A linear tetrapyrrole produced in the reticuloendothelial system by the first step of heme degradation, catalysed by heme oxygenase.
Synonyms:related_synonym: 8,12-bis(2-carboxyethyl)-2,7,13,17-tetramethyl-3,18-divinylbilin-1(19)(21H,24H)-dione;   BILIVERDINE IX ALPHA;   Biliverdin IX alpha;   Biliverdin IXalpha;   Biliverdine;   Formula=C33H34N4O6;   InChI=1S/C33H34N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-15,35H,1-2,9-12H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/b26-13-,27-14-,28-15-;   InChIKey=QBUVFDKTZJNUPP-BBROENKCSA-N;   SMILES=CC1=C(CCC(O)=O)\\C(/N=C1/C=C1NC(=O)C(C=C)=C/1C)=C\\c1[nH]c(\\C=C2NC(=O)C(C)=C/2C=C)c(C)c1CCC(O)=O
 alt_id: CHEBI:13901;   CHEBI:13902;   CHEBI:22875;   CHEBI:3102;   CHEBI:41124
 xref: Beilstein:74351;   CAS:114-25-0;   DrugBank:DB02073;   HMDB:HMDB0001008;   KEGG:C00500
 xref_mesh: MESH:D001664
 xref: PDBeChem:BLA;   PMID:14977878;   PMID:19617398;   Reaxys:74351;   Wikipedia:Biliverdin
 cyclic_relationship: is_conjugate_acid_of CHEBI:57991


show annotations for term's descendants           Sort by:
biliverdin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO Biliverdine inhibits the reaction [IL18 protein results in decreased phosphorylation of AKT1 protein] CTD PMID:18215737 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO [Methylene Chloride co-treated with Biliverdine] inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased activity of CASP3 protein]; Biliverdine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased activity of CASP3 protein] CTD PMID:15486963 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO [cobaltiprotoporphyrin results in increased activity of HMOX1 protein] which results in increased chemical synthesis of Biliverdine CTD PMID:26224716 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Ifng interferon gamma multiple interactions ISO [Methylene Chloride co-treated with Biliverdine] inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of IFNG protein] CTD PMID:15486963 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO [Methylene Chloride co-treated with Biliverdine] inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of IL10 protein] CTD PMID:15486963 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il18 interleukin 18 multiple interactions
decreases response to substance		 ISO Biliverdine inhibits the reaction [IL18 protein results in decreased phosphorylation of AKT1 protein]; Biliverdine inhibits the reaction [IL18 protein results in increased expression of PTEN protein]
Biliverdine results in decreased susceptibility to IL18 protein		 CTD PMID:18215737 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO [Methylene Chloride co-treated with Biliverdine] inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of IL6 protein] CTD PMID:15486963 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Pten phosphatase and tensin homolog multiple interactions ISO Biliverdine inhibits the reaction [IL18 protein results in increased expression of PTEN protein] CTD PMID:18215737 NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [Methylene Chloride co-treated with Biliverdine] inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of TNF protein] CTD PMID:15486963 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19917
    role 19887
      biological role 19885
        biochemical role 19569
          metabolite 19577
            eukaryotic metabolite 19378
              animal metabolite 19265
                mammalian metabolite 19264
                  human metabolite 18776
                    biliverdin 9
                      15,16-dihydrobiliverdin 0
                      biliverdin hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19917
    subatomic particle 19915
      composite particle 19915
        hadron 19915
          baryon 19915
            nucleon 19915
              atomic nucleus 19915
                atom 19915
                  main group element atom 19855
                    p-block element atom 19855
                      carbon group element atom 19774
                        carbon atom 19790
                          organic molecular entity 19790
                            organic molecule 19743
                              organic cyclic compound 19533
                                organic heterocyclic compound 18903
                                  organonitrogen heterocyclic compound 18182
                                    polypyrrole 697
                                      tetrapyrrole 584
                                        linear tetrapyrrole 176
                                          bilins 9
                                            biliverdin 9
                                              15,16-dihydrobiliverdin 0
                                              biliverdin hydrochloride 0
paths to the root