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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:bilirubin IXalpha
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Accession:CHEBI:16990 term browser browse the term
Definition:A member of the class of biladienes that is a linear tetrapyrrole with the dipyrrole units being of both exovinyl and endovinyl type. A product of heme degradation, it is produced in the reticuloendothelial system by the reduction of biliverdin and transported to the liver as a complex with serum albumin.
Synonyms:related_synonym: 1,10,19,22,23,24-hexahydro-2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinylbiline-8,12-dipropionic acid;   2,17-diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo-21H-biline-8,12-dipropanoic acid;   2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinyl-1,10,19,22,23,24-hexahydro-21H-biline-8,12-dipropanoic acid;   8,12-bis(2-carboxyethyl)-2,7,13,17-tetramethyl-3,18-divinylbiladiene-ac-1,19(21H,24H)-dione;   Bilirubin;   Formula=C33H36N4O6;   InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/b26-13-,27-14-;   InChIKey=BPYKTIZUTYGOLE-IFADSCNNSA-N;   SMILES=CC1=C(C=C)\\C(NC1=O)=C\\C1=C(C)C(CCC(O)=O)=C(CC2=C(CCC(O)=O)C(C)=C(N2)\\C=C2/NC(=O)C(C=C)=C2C)N1;   bilirubin(Z,Z)
 alt_id: CHEBI:13898;   CHEBI:22870;   CHEBI:3099
 xref: CAS:635-65-4;   Gmelin:411033;   HMDB:HMDB0000054;   KEGG:C00486;   KNApSAcK:C00029828
 xref_mesh: MESH:D001663
 xref: MetaCyc:BILIRUBIN;   PDBeChem:BLR;   PMID:12799017;   PMID:18442622;   PMID:23763371;   PMID:23768684;   PMID:30224965;   PMID:8605219;   PMID:9587403;   Reaxys:74376;   Wikipedia:Bilirubin
 cyclic_relationship: is_conjugate_acid_of CHEBI:57977


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bilirubin IXalpha term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions EXP Bilirubin analog inhibits the reaction [tert-Butylhydroperoxide affects the localization of and results in decreased activity of ABCB11 protein] CTD PMID:24306262 NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 affects transport
multiple interactions 		ISO ABCC1 protein affects the transport of Bilirubin
Adenosine Triphosphate promotes the reaction [ABCC1 protein affects the transport of Bilirubin]; Bilirubin inhibits the reaction [ABCC1 protein affects the transport of Leukotriene C4]; Glutathione promotes the reaction [ABCC1 protein affects the transport of Bilirubin]; verlukast inhibits the reaction [ABCC1 protein affects the transport of Bilirubin] 		CTD PMID:15245331 NCBI chr10:1,022,041...1,162,431
Ensembl chr10:1,038,947...1,162,404 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases activity
affects transport
multiple interactions 		EXP Bilirubin results in decreased activity of ABCC2 protein
ABCC2 protein affects the transport of Bilirubin
Bilirubin analog inhibits the reaction [tert-Butylhydroperoxide affects the localization of and results in decreased activity of ABCC2 protein] 		CTD PMID:15374814 PMID:15901347 PMID:24306262 NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO [[Bilirubin binds to and results in increased activity of AHR protein] which binds to CYP1A promoter] which results in increased expression of CYP1A mRNA CTD PMID:18187559 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO Bilirubin inhibits the reaction [IL18 protein results in decreased phosphorylation of AKT1 protein] CTD PMID:18215737 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Alad aminolevulinate dehydratase decreases expression
multiple interactions 		ISO
EXP 		Bilirubin results in decreased expression of ALAD mRNA
Bilirubin inhibits the reaction [Aminolevulinic Acid results in increased activity of ALAD protein] 		CTD PMID:12853123 PMID:20196124 NCBI chr 5:80,977,562...80,987,901
Ensembl chr 5:80,977,562...80,988,041 		JBrowse link
G Alas1 5'-aminolevulinate synthase 1 multiple interactions EXP Bilirubin inhibits the reaction [Aminolevulinic Acid results in increased activity of ALAS1 protein] CTD PMID:12853123 NCBI chr 8:115,755,238...115,768,642
Ensembl chr 8:115,755,238...115,768,642 		JBrowse link
G Alb albumin affects binding
multiple interactions 		ISO
EXP 		ALB protein binds to Bilirubin; Bilirubin binds to ALB protein
[homocysteine thiolactone results in increased metabolism of ALB protein] affects the reaction [ALB protein binds to Bilirubin]; Sulfisoxazole inhibits the reaction [Bilirubin binds to ALB protein]
Folic Acid inhibits the reaction [Homocysteine inhibits the reaction [ALB protein binds to Bilirubin]]; Folic Acid inhibits the reaction [phenylhydrazine inhibits the reaction [ALB protein binds to Bilirubin]]; Homocysteine inhibits the reaction [ALB protein binds to Bilirubin]; phenylhydrazine inhibits the reaction [ALB protein binds to Bilirubin] 		CTD PMID:21280114 PMID:33788065 NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865 		JBrowse link
G Alpl alkaline phosphatase, biomineralization associated decreases expression EXP Bilirubin results in decreased expression of ALPL mRNA CTD PMID:20020468 NCBI chr 5:155,234,770...155,289,785
Ensembl chr 5:155,234,775...155,254,167 		JBrowse link
G Anxa1 annexin A1 decreases expression ISO Bilirubin results in decreased expression of ANXA1 mRNA CTD PMID:20196124 NCBI chr 1:227,287,713...227,306,739
Ensembl chr 1:227,287,717...227,306,831 		JBrowse link
G Areg amphiregulin increases expression ISO Bilirubin results in increased expression of AREG mRNA CTD PMID:20196124 NCBI chr14:17,256,384...17,265,641
Ensembl chr14:17,256,384...17,265,641 		JBrowse link
G Arhgap29 Rho GTPase activating protein 29 decreases expression ISO Bilirubin results in decreased expression of ARHGAP29 mRNA CTD PMID:20196124 NCBI chr 2:212,744,626...212,816,710
Ensembl chr 2:212,755,803...212,986,729 		JBrowse link
G Asb13 ankyrin repeat and SOCS box-containing 13 decreases expression ISO Bilirubin results in decreased expression of ASB13 mRNA CTD PMID:20196124 NCBI chr17:66,564,653...66,583,365
Ensembl chr17:71,474,531...71,505,633 		JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Bilirubin results in increased expression of ATF3 mRNA CTD PMID:20196124 NCBI chr13:105,274,103...105,331,653
Ensembl chr13:105,282,440...105,295,750 		JBrowse link
G Atf6 activating transcription factor 6 increases expression
multiple interactions 		ISO Bilirubin results in increased expression of ATF6 mRNA
4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased expression of ATF6 mRNA] 		CTD PMID:27578021 NCBI chr13:85,460,312...85,639,959
Ensembl chr13:85,462,840...85,640,033 		JBrowse link
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 decreases expression ISO Bilirubin results in decreased expression of ATP1A1 mRNA CTD PMID:20196124 NCBI chr 2:191,709,311...191,737,414
Ensembl chr 2:191,709,311...191,737,425 		JBrowse link
G Axin2 axin 2 decreases expression ISO Bilirubin results in decreased expression of AXIN2 mRNA CTD PMID:20196124 NCBI chr10:94,393,379...94,426,579
Ensembl chr10:94,395,909...94,426,575 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO Bilirubin promotes the reaction [Iron-Dextran Complex results in increased expression of BCL2L1 protein] CTD PMID:20709802 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907 		JBrowse link
G Bglap bone gamma-carboxyglutamate protein decreases expression EXP Bilirubin results in decreased expression of BGLAP mRNA CTD PMID:20020468 NCBI chr 2:176,136,341...176,137,318
Ensembl chr 2:176,136,341...176,137,318 		JBrowse link
G Bloc1s1 biogenesis of lysosomal organelles complex-1, subunit 1 decreases expression ISO Bilirubin results in decreased expression of BLOC1S1 mRNA CTD PMID:20196124 NCBI chr 7:1,347,495...1,351,103
Ensembl chr 7:1,925,335...1,936,049 		JBrowse link
G C1d C1D nuclear receptor corepressor decreases expression ISO Bilirubin results in decreased expression of C1D mRNA CTD PMID:20196124 NCBI chr14:91,660,951...91,673,177
Ensembl chr14:95,861,978...95,874,796 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases activity 		ISO
EXP 		4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased cleavage of CASP3 protein]; Bilirubin inhibits the reaction [Iron-Dextran Complex results in increased activity of CASP3 protein]; CYP2A5 protein inhibits the reaction [Bilirubin results in increased cleavage of CASP3 protein]
Bilirubin results in increased activity of CASP3 protein 		CTD PMID:20709802 PMID:23628428 PMID:27578021 PMID:28805483 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Cat catalase decreases expression
multiple interactions 		ISO
EXP 		Bilirubin results in decreased expression of CAT mRNA
Bilirubin inhibits the reaction [Aminolevulinic Acid results in decreased activity of CAT protein] 		CTD PMID:12853123 PMID:20196124 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Ccdc80 coiled-coil domain containing 80 decreases expression ISO Bilirubin results in decreased expression of CCDC80 mRNA CTD PMID:20196124 NCBI chr11:69,191,188...69,224,844
Ensembl chr11:69,191,189...69,224,844 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Bilirubin results in decreased expression of CCND1 mRNA CTD PMID:20196124 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810 		JBrowse link
G Cd302 CD302 molecule decreases expression ISO Bilirubin results in decreased expression of CD302 mRNA CTD PMID:20196124 NCBI chr 3:44,722,324...44,756,045
Ensembl chr 3:65,113,102...65,164,737 		JBrowse link
G Chac1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 increases expression ISO Bilirubin results in increased expression of CHAC1 mRNA CTD PMID:20196124 NCBI chr 3:126,796,131...126,799,352
Ensembl chr 3:126,796,024...126,799,361 		JBrowse link
G Chka choline kinase alpha increases expression ISO Bilirubin results in increased expression of CHKA mRNA CTD PMID:20196124 NCBI chr 1:210,506,069...210,554,753
Ensembl chr 1:210,506,056...210,554,752 		JBrowse link
G Clcc1 chloride channel CLIC-like 1 decreases expression ISO Bilirubin results in decreased expression of CLCC1 mRNA CTD PMID:20196124 NCBI chr 2:198,984,455...199,015,015
Ensembl chr 2:198,984,495...199,015,014 		JBrowse link
G Clip1 CAP-GLY domain containing linker protein 1 decreases expression ISO Bilirubin results in decreased expression of CLIP1 mRNA CTD PMID:20196124 NCBI chr12:38,571,533...38,678,779
Ensembl chr12:38,571,834...38,678,779 		JBrowse link
G Col3a1 collagen type III alpha 1 chain decreases expression ISO Bilirubin results in decreased expression of COL3A1 mRNA CTD PMID:20196124 NCBI chr 9:54,866,646...54,902,578
Ensembl chr 9:54,866,632...54,903,232 		JBrowse link
G Cox15 cytochrome c oxidase assembly homolog COX15 decreases expression ISO Bilirubin results in decreased expression of COX15 mRNA CTD PMID:20196124 NCBI chr 1:252,554,811...252,571,471
Ensembl chr 1:252,554,811...252,571,471 		JBrowse link
G Cpd carboxypeptidase D decreases expression ISO Bilirubin results in decreased expression of CPD mRNA CTD PMID:20196124 NCBI chr10:62,121,681...62,185,638
Ensembl chr10:62,121,679...62,185,638 		JBrowse link
G Csf2 colony stimulating factor 2 increases expression ISO Bilirubin results in increased expression of CSF2 mRNA CTD PMID:20196124 NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,887,692...38,890,031 		JBrowse link
G Ctsh cathepsin H decreases expression ISO Bilirubin results in decreased expression of CTSH mRNA CTD PMID:20196124 NCBI chr 8:99,488,756...99,507,639
Ensembl chr 8:99,488,874...99,509,181 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 increases expression ISO Bilirubin results in increased expression of CXCL10 mRNA CTD PMID:20196124 NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,989,018...15,991,261 		JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 increases expression ISO Bilirubin results in increased expression of CXCL11 mRNA CTD PMID:20196124 NCBI chr14:15,973,728...15,976,503
Ensembl chr14:15,973,720...15,976,567 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression ISO Bilirubin results in increased expression of CXCL2 mRNA CTD PMID:20196124 NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,465,242...17,467,255 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO Bilirubin results in increased expression of CYP1A1 mRNA; Bilirubin results in increased expression of CYP1A1 protein CTD PMID:20196124 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO Bilirubin results in decreased activity of CYP1A2 protein CTD PMID:16183037 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression
multiple interactions 		ISO Bilirubin results in increased expression of CYP2B6 mRNA
IL1B protein inhibits the reaction [Bilirubin results in increased expression of CYP2B6 mRNA] 		CTD PMID:15382119 NCBI chr 1:90,780,468...90,859,852 JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression
multiple interactions 		ISO
EXP 		Bilirubin results in increased expression of CYP3A4 mRNA
IL1B protein inhibits the reaction [Bilirubin results in increased expression of CYP3A4 mRNA]
[CYP3A23-3A1 gene mutant form co-treated with CYP3A2 gene mutant form] results in increased abundance of Bilirubin 		CTD PMID:15382119 PMID:34461081 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857 		JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 multiple interactions EXP [CYP3A23-3A1 gene mutant form co-treated with CYP3A2 gene mutant form] results in increased abundance of Bilirubin CTD PMID:34461081 NCBI chr12:14,369,950...14,398,803
Ensembl chr12:14,368,266...14,398,813 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions
decreases activity 		EXP [Manganese co-treated with Bilirubin] results in decreased activity of CYP7A1 protein
Bilirubin results in decreased activity of CYP7A1 protein 		CTD PMID:12700418 NCBI chr 5:24,174,505...24,184,202
Ensembl chr 5:24,174,505...24,184,202 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
multiple interactions 		ISO
EXP 		Bilirubin results in increased expression of DDIT3 mRNA
4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased expression of DDIT3 mRNA]; [Bilirubin co-treated with Rotenone] promotes the reaction [Cannabidiol results in increased expression of DDIT3 mRNA]; Bilirubin inhibits the reaction [Cannabidiol results in increased expression of DDIT3 mRNA]
Bilirubin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of DDIT3 mRNA] 		CTD PMID:20196124 PMID:27578021 PMID:32033040 PMID:37054934 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509 		JBrowse link
G Deptor DEP domain containing MTOR-interacting protein decreases expression ISO Bilirubin results in decreased expression of DEPTOR mRNA CTD PMID:20196124 NCBI chr 7:88,404,745...88,574,065
Ensembl chr 7:88,404,620...88,574,041 		JBrowse link
G Dmkn dermokine decreases expression ISO Bilirubin results in decreased expression of DMKN mRNA CTD PMID:20196124 NCBI chr 1:95,140,737...95,158,676
Ensembl chr 1:95,141,620...95,157,439 		JBrowse link
G Dnajb1 DnaJ heat shock protein family (Hsp40) member B1 affects expression ISO Bilirubin affects the expression of DNAJB1 mRNA CTD PMID:20196124 NCBI chr19:41,427,453...41,431,141
Ensembl chr19:41,427,453...41,431,416 		JBrowse link
G Dnpep aspartyl aminopeptidase decreases expression ISO Bilirubin results in decreased expression of DNPEP mRNA CTD PMID:20196124 NCBI chr 9:84,248,581...84,257,484
Ensembl chr 9:84,233,486...84,256,977 		JBrowse link
G Dpy19l1 dpy-19 like C-mannosyltransferase 1 decreases expression ISO Bilirubin results in decreased expression of DPY19L1 mRNA CTD PMID:20196124 NCBI chr 8:22,933,163...23,021,461
Ensembl chr 8:31,209,025...31,297,518 		JBrowse link
G Dusp5 dual specificity phosphatase 5 increases expression ISO Bilirubin results in increased expression of DUSP5 mRNA CTD PMID:20196124 NCBI chr 1:262,543,774...262,557,201
Ensembl chr 1:262,543,738...262,562,417 		JBrowse link
G Edn1 endothelin 1 multiple interactions ISO Bilirubin inhibits the reaction [cobaltous chloride results in increased expression of EDN1 mRNA]; Bilirubin inhibits the reaction [cobaltous chloride results in increased secretion of EDN1 protein] CTD PMID:27297870 NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,660,799...22,666,687 		JBrowse link
G Egln1 egl-9 family hypoxia-inducible factor 1 decreases expression ISO Bilirubin results in decreased expression of EGLN1 mRNA CTD PMID:20196124 NCBI chr19:69,765,276...69,804,681 JBrowse link
G Ei24 EI24, autophagy associated transmembrane protein decreases expression ISO Bilirubin results in decreased expression of EI24 mRNA CTD PMID:20196124 NCBI chr 8:36,494,289...36,510,653
Ensembl chr 8:44,683,144...44,695,214 		JBrowse link
G Eid1 EP300 interacting inhibitor of differentiation 1 decreases expression ISO Bilirubin results in decreased expression of EID1 mRNA CTD PMID:20196124 NCBI chr 3:112,922,961...112,924,680
Ensembl chr 3:133,370,474...133,378,434 		JBrowse link
G Eif2ak1 eukaryotic translation initiation factor 2 alpha kinase 1 multiple interactions ISO [lead nitrate co-treated with EIF2AK1 gene mutant form] results in increased abundance of Bilirubin CTD PMID:25411909 NCBI chr12:15,824,431...15,858,266
Ensembl chr12:15,825,124...15,858,281 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions ISO Bilirubin results in increased phosphorylation of and results in increased activity of EIF2AK3 protein; EIF2AK3 mRNA promotes the reaction [Bilirubin results in increased expression of CXCL8 mRNA] CTD PMID:20196124 PMID:27578021 NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:104,363,833...104,425,268 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions ISO Bilirubin results in increased phosphorylation of and results in increased activity of EIF2S1 protein CTD PMID:20196124 NCBI chr 6:103,405,880...103,430,549
Ensembl chr 6:103,405,788...103,431,649 		JBrowse link
G Endod1 endonuclease domain containing 1 decreases expression ISO Bilirubin results in decreased expression of ENDOD1 mRNA CTD PMID:20196124 NCBI chr 8:11,209,113...11,238,507
Ensembl chr 8:19,490,615...19,520,007 		JBrowse link
G Fam174a family with sequence similarity 174, member A decreases expression ISO Bilirubin results in decreased expression of FAM174A mRNA CTD PMID:20196124 NCBI chr 9:95,742,815...95,761,083
Ensembl chr 9:103,190,127...103,209,228 		JBrowse link
G Fgf19 fibroblast growth factor 19 increases abundance ISO FGF15 gene mutant form results in increased abundance of Bilirubin CTD PMID:24699334 NCBI chr 1:200,056,526...200,060,980
Ensembl chr 1:209,485,813...209,490,267 		JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 multiple interactions ISO Bilirubin inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein] CTD PMID:25371888 NCBI chr12:12,333,050...12,504,750
Ensembl chr12:12,333,430...12,504,750 		JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression ISO Bilirubin results in increased expression of FOSL1 mRNA CTD PMID:20196124 NCBI chr 1:212,183,885...212,192,391
Ensembl chr 1:212,183,833...212,192,391 		JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta increases expression ISO Bilirubin results in increased expression of GADD45B mRNA CTD PMID:20196124 NCBI chr 7:9,428,689...9,430,991
Ensembl chr 7:9,428,689...9,430,718 		JBrowse link
G Gas5 growth arrest specific 5 decreases expression ISO Bilirubin results in decreased expression of GAS5 mRNA CTD PMID:20196124 NCBI chr13:73,303,611...73,306,932 JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions EXP Bilirubin inhibits the reaction [Aminolevulinic Acid results in decreased activity of GPX1 protein] CTD PMID:12853123 NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581 		JBrowse link
G Gsn gelsolin decreases expression ISO Bilirubin results in decreased expression of GSN mRNA CTD PMID:20196124 NCBI chr 3:38,982,605...39,035,849
Ensembl chr 3:38,982,671...39,035,850 		JBrowse link
G Gsta1 glutathione S-transferase alpha 1 increases expression
multiple interactions 		ISO Bilirubin results in increased expression of GSTA1 mRNA
IL1B protein inhibits the reaction [Bilirubin results in increased expression of GSTA1 mRNA] 		CTD PMID:15382119 NCBI chr 9:31,199,887...31,216,606
Ensembl chr 9:31,199,888...31,211,528 		JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression
multiple interactions
affects binding 		ISO
EXP 		Bilirubin results in increased expression of GSTA2 mRNA
IL1B protein inhibits the reaction [Bilirubin results in increased expression of GSTA2 mRNA]
Bilirubin binds to GSTA2 protein 		CTD PMID:1148165 PMID:2768223 PMID:15382119 NCBI chr 8:88,064,829...88,077,168
Ensembl chr 8:88,064,616...88,077,092 		JBrowse link
G Gsta4 glutathione S-transferase alpha 4 decreases expression ISO Bilirubin results in decreased expression of GSTA4 mRNA CTD PMID:20196124 NCBI chr 8:87,947,247...87,964,490
Ensembl chr 8:87,930,566...87,964,488 		JBrowse link
G Gstk1 glutathione S-transferase kappa 1 decreases expression ISO Bilirubin results in decreased expression of GSTK1 mRNA CTD PMID:20196124 NCBI chr 4:72,085,532...72,089,934
Ensembl chr 4:72,085,531...72,089,927 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases expression ISO Bilirubin results in decreased expression of GSTM1 mRNA CTD PMID:20196124 NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:198,338,008...198,343,569 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases expression ISO Bilirubin results in decreased expression of GSTP1 mRNA CTD PMID:20196124 NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705 		JBrowse link
G H1f4 H1.4 linker histone, cluster member increases expression ISO Bilirubin results in increased expression of H1-4 mRNA CTD PMID:20196124 NCBI chr17:41,914,425...41,915,206
Ensembl chr17:41,914,431...41,916,129 		JBrowse link
G H2ac25 H2A clustered histone 25 increases expression ISO Bilirubin results in increased expression of H2AC25 mRNA CTD PMID:20196124 NCBI chr10:43,733,702...43,735,254
Ensembl chr10:44,233,181...44,241,197 		JBrowse link
G Hacd4 3-hydroxyacyl-CoA dehydratase 4 decreases expression ISO Bilirubin results in decreased expression of HACD4 mRNA CTD PMID:20196124 NCBI chr 5:102,887,597...102,915,376
Ensembl chr 5:107,934,937...107,962,836 		JBrowse link
G Heph hephaestin decreases expression ISO Bilirubin results in decreased expression of HEPH mRNA CTD PMID:20196124 NCBI chr  X:65,160,628...65,412,457
Ensembl chr  X:65,305,773...65,412,453 		JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 increases expression ISO Bilirubin results in increased expression of HERPUD1 mRNA CTD PMID:20196124 NCBI chr19:10,604,360...10,624,168
Ensembl chr19:10,604,362...10,624,081 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO Bilirubin inhibits the reaction [cobaltous chloride results in increased expression of HIF1A mRNA]; Bilirubin inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein] CTD PMID:27297870 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323 		JBrowse link
G Hist1h4b histone cluster 1 H4 family member B increases expression ISO Bilirubin results in increased expression of H4C9 mRNA CTD PMID:20196124 NCBI chr17:42,480,467...42,484,912
Ensembl chr17:41,797,152...41,806,539
Ensembl chr17:41,797,152...41,806,539
Ensembl chr17:41,797,152...41,806,539
Ensembl chr 4:41,797,152...41,806,539 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions EXP [Manganese co-treated with Bilirubin] results in decreased activity of HMGCR protein CTD PMID:12700418 NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases abundance
affects activity
increases expression
increases chemical synthesis 		EXP
ISO 		[[Galactosamine co-treated with Lipopolysaccharides] results in increased expression of HMOX1 mRNA] which results in increased chemical synthesis of Bilirubin; [cobaltiprotoporphyrin results in increased expression of HMOX1 protein] which results in increased abundance of Bilirubin; Bilirubin inhibits the reaction [Aminolevulinic Acid results in increased activity of HMOX1 protein]
HMOX1 protein results in increased abundance of Bilirubin
[Ethanol results in increased expression of HMOX1 protein] which results in increased abundance of Bilirubin; Atazanavir Sulfate promotes the reaction [HMOX1 protein results in increased chemical synthesis of Bilirubin]; Bilirubin inhibits the reaction [[tin protoporphyrin IX results in decreased activity of HMOX1 protein] which results in increased chemical synthesis of Reactive Oxygen Species]; Bilirubin inhibits the reaction [Ritonavir results in increased expression of HMOX1 protein]; Lopinavir promotes the reaction [HMOX1 protein results in increased chemical synthesis of Bilirubin]; Ritonavir promotes the reaction [HMOX1 protein results in increased chemical synthesis of Bilirubin]
Bilirubin affects the activity of HMOX1 protein
Bilirubin results in increased expression of HMOX1 mRNA
[Rotenone co-treated with Bilirubin] inhibits the reaction [Cannabidiol results in increased expression of HMOX1 mRNA]; Bilirubin inhibits the reaction [Cannabidiol results in increased expression of HMOX1 mRNA]; sodium arsenite promotes the reaction [HMOX1 protein results in increased chemical synthesis of Bilirubin] 		CTD PMID:12690112 PMID:12853123 PMID:15226216 PMID:15602829 PMID:20196124 More... NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Hmox2 heme oxygenase 2 affects abundance ISO HMOX2 affects the abundance of Bilirubin CTD PMID:16181104 NCBI chr10:10,797,076...10,831,178
Ensembl chr10:11,303,512...11,318,800 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression
multiple interactions 		ISO
EXP 		Bilirubin results in increased expression of HSPA5 mRNA; Bilirubin results in increased expression of HSPA5 protein
4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased expression of HSPA5 mRNA]; Bilirubin inhibits the reaction [[Cannabidiol co-treated with Rotenone] results in increased expression of HSPA5 mRNA]
Bilirubin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of HSPA5 mRNA] 		CTD PMID:20196124 PMID:27578021 PMID:32033040 PMID:37054934 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790 		JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 decreases expression ISO Bilirubin results in decreased expression of IDH2 mRNA CTD PMID:20196124 NCBI chr 1:143,447,925...143,467,248
Ensembl chr 1:143,439,323...143,467,248 		JBrowse link
G Ifrd1 interferon-related developmental regulator 1 increases expression ISO Bilirubin results in increased expression of IFRD1 mRNA CTD PMID:20196124 NCBI chr 6:62,996,560...63,044,996
Ensembl chr 6:62,996,562...63,016,131 		JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 decreases expression ISO Bilirubin results in decreased expression of IGFBP3 mRNA CTD PMID:20196124 NCBI chr14:86,270,208...86,277,944
Ensembl chr14:86,270,208...86,277,944 		JBrowse link
G Il18 interleukin 18 multiple interactions
decreases response to substance 		ISO Bilirubin inhibits the reaction [IL18 protein results in decreased phosphorylation of AKT1 protein]; Bilirubin inhibits the reaction [IL18 protein results in increased expression of PTEN protein]
Bilirubin results in decreased susceptibility to IL18 protein 		CTD PMID:18215737 NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:59,809,592...59,831,286 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP 		IL1B protein inhibits the reaction [Bilirubin results in increased expression of CYP2B6 mRNA]; IL1B protein inhibits the reaction [Bilirubin results in increased expression of CYP2C9 mRNA]; IL1B protein inhibits the reaction [Bilirubin results in increased expression of CYP3A4 mRNA]; IL1B protein inhibits the reaction [Bilirubin results in increased expression of GSTA1 mRNA]; IL1B protein inhibits the reaction [Bilirubin results in increased expression of GSTA2 mRNA]; IL1B protein inhibits the reaction [Bilirubin results in increased expression of SLCO1B1 mRNA]; IL1B protein inhibits the reaction [Bilirubin results in increased expression of UGT1A1 mRNA]
Bilirubin inhibits the reaction [Cyclophosphamide results in increased expression of IL1B mRNA] 		CTD PMID:15382119 PMID:18206168 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions 		ISO Bilirubin results in increased expression of IL6 mRNA
[Rotenone co-treated with Bilirubin] inhibits the reaction [Cannabidiol results in increased expression of IL6 mRNA]; Bilirubin inhibits the reaction [Cannabidiol results in increased expression of IL6 mRNA] 		CTD PMID:20196124 PMID:32033040 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Kl Klotho decreases expression EXP Bilirubin results in decreased expression of KL mRNA; Bilirubin results in decreased expression of KL protein CTD PMID:28805483 NCBI chr12:490,402...531,417
Ensembl chr12:5,325,959...5,367,015 		JBrowse link
G Lamb1 laminin subunit beta 1 decreases expression ISO Bilirubin results in decreased expression of LAMB1 mRNA CTD PMID:20196124 NCBI chr 6:53,562,849...53,630,118
Ensembl chr 6:53,563,073...53,630,760 		JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 decreases expression ISO Bilirubin results in decreased expression of LAMP2 mRNA CTD PMID:20196124 NCBI chr  X:122,038,734...122,087,745
Ensembl chr  X:121,922,187...122,087,675 		JBrowse link
G Leprot leptin receptor overlapping transcript decreases expression ISO Bilirubin results in decreased expression of LEPROT mRNA CTD PMID:20196124 NCBI chr 5:121,405,170...121,417,273
Ensembl chr 5:121,404,759...121,417,275 		JBrowse link
G Lif LIF, interleukin 6 family cytokine increases expression ISO Bilirubin results in increased expression of LIF mRNA CTD PMID:20196124 NCBI chr14:83,354,602...83,364,053
Ensembl chr14:83,358,164...83,364,053 		JBrowse link
G Lrp1 LDL receptor related protein 1 decreases expression ISO Bilirubin results in decreased expression of LRP1 mRNA CTD PMID:20196124 NCBI chr 7:65,265,639...65,346,196
Ensembl chr 7:65,265,639...65,346,196 		JBrowse link
G Ly6al1 lymphocyte antigen 6 complex, locus A like 1 decreases expression ISO Bilirubin results in decreased expression of LY6A mRNA CTD PMID:20196124 NCBI chr 7:107,011,585...107,018,125
Ensembl chr 7:108,892,339...108,895,989 		JBrowse link
G Maf MAF bZIP transcription factor decreases expression ISO Bilirubin results in decreased expression of MAF mRNA CTD PMID:20196124 NCBI chr19:60,259,200...60,622,145
Ensembl chr19:60,269,541...60,621,378 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO Bilirubin results in decreased phosphorylation of MAPK1 protein CTD PMID:12690112 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO Bilirubin results in decreased phosphorylation of MAPK3 protein CTD PMID:12690112 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mapre2 microtubule-associated protein, RP/EB family, member 2 decreases expression ISO Bilirubin results in decreased expression of MAPRE2 mRNA CTD PMID:20196124 NCBI chr18:15,303,502...15,444,306
Ensembl chr18:15,303,533...15,442,796 		JBrowse link
G Me2 malic enzyme 2 decreases expression ISO Bilirubin results in decreased expression of ME2 mRNA CTD PMID:20196124 NCBI chr18:67,350,833...67,400,987
Ensembl chr18:69,626,087...69,676,218 		JBrowse link
G Megf9 multiple EGF-like-domains 9 decreases expression ISO Bilirubin results in decreased expression of MEGF9 mRNA CTD PMID:20196124 NCBI chr 5:83,993,565...84,105,622
Ensembl chr 5:89,008,679...89,120,731 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase increases secretion ISO MET gene mutant form results in increased secretion of Bilirubin CTD PMID:27394961 NCBI chr 4:46,756,823...46,864,041
Ensembl chr 4:46,756,506...46,870,821 		JBrowse link
G Mgst2 microsomal glutathione S-transferase 2 decreases expression ISO Bilirubin results in decreased expression of MGST2 mRNA CTD PMID:20196124 NCBI chr 2:137,821,787...137,866,664
Ensembl chr 2:137,836,140...137,866,661 		JBrowse link
G Mmp13 matrix metallopeptidase 13 increases expression ISO Bilirubin results in increased expression of MMP13 mRNA CTD PMID:20196124 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:12,782,813...12,793,105 		JBrowse link
G Mpzl2 myelin protein zero-like 2 decreases expression ISO Bilirubin results in decreased expression of MPZL2 mRNA CTD PMID:20196124 NCBI chr 8:54,244,920...54,256,064
Ensembl chr 8:54,243,556...54,256,074 		JBrowse link
G Mrpl18 mitochondrial ribosomal protein L18 decreases expression ISO Bilirubin results in decreased expression of MRPL18 mRNA CTD PMID:20196124 NCBI chr 1:50,384,951...50,389,769
Ensembl chr 1:50,384,367...50,389,763 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects localization
multiple interactions 		ISO Bilirubin affects the localization of NFE2L2 protein
Bilirubin promotes the reaction [NFE2L2 protein results in increased expression of CYP2A5 mRNA] 		CTD PMID:23628428 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP Bilirubin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of NFKB1 mRNA] CTD PMID:37054934 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088 		JBrowse link
G Nid1 nidogen 1 decreases expression ISO Bilirubin results in decreased expression of NID1 mRNA CTD PMID:20196124 NCBI chr17:86,085,133...86,158,272
Ensembl chr17:93,069,278...93,142,386 		JBrowse link
G Nnt nicotinamide nucleotide transhydrogenase decreases expression ISO Bilirubin results in decreased expression of NNT mRNA CTD PMID:20196124 NCBI chr 2:51,411,413...51,505,125
Ensembl chr 2:53,144,160...53,237,310 		JBrowse link
G Noct nocturnin increases expression ISO Bilirubin results in increased expression of NOCT mRNA CTD PMID:20196124 NCBI chr 2:137,422,074...137,442,282
Ensembl chr 2:137,422,074...137,442,282 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP Bilirubin inhibits the reaction [Cyclophosphamide results in increased expression of NOS2 mRNA]; Bilirubin inhibits the reaction [Cyclophosphamide results in increased expression of NOS2 protein] CTD PMID:18206168 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases expression
affects abundance
affects transport 		ISO Bilirubin results in increased expression of NR1I2 mRNA
NR1I2 protein affects the abundance of Bilirubin
NR1I2 protein affects the transport of Bilirubin 		CTD PMID:15726644 PMID:18706437 NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases expression ISO Bilirubin results in increased expression of NR1I3 mRNA CTD PMID:18706437 NCBI chr13:86,165,327...86,170,362
Ensembl chr13:86,165,349...86,170,370 		JBrowse link
G Osgin1 oxidative stress induced growth inhibitor 1 increases expression ISO Bilirubin results in increased expression of OSGIN1 mRNA CTD PMID:20196124 NCBI chr19:47,471,750...47,500,517
Ensembl chr19:64,401,173...64,409,162 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases expression
multiple interactions 		ISO Bilirubin results in increased expression of PARP1 protein modified form
4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased expression of PARP1 protein modified form] 		CTD PMID:27578021 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567 		JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 decreases expression ISO Bilirubin results in decreased expression of PDK1 mRNA CTD PMID:20196124 NCBI chr 3:77,113,464...77,144,145
Ensembl chr 3:77,113,473...77,144,145 		JBrowse link
G Pgap2 post-GPI attachment to proteins 2 decreases expression ISO Bilirubin results in decreased expression of PGAP2 mRNA CTD PMID:20196124 NCBI chr 1:166,003,593...166,030,088
Ensembl chr 1:166,003,523...166,030,088 		JBrowse link
G Phb1 prohibitin 1 decreases expression ISO Bilirubin results in decreased expression of PHB1 mRNA CTD PMID:20196124 NCBI chr10:81,102,043...81,114,815
Ensembl chr10:81,102,028...81,116,233 		JBrowse link
G Pias1 protein inhibitor of activated STAT, 1 decreases expression ISO Bilirubin results in decreased expression of PIAS1 mRNA CTD PMID:20196124 NCBI chr 8:63,338,150...63,451,670
Ensembl chr 8:72,233,566...72,334,315 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 decreases expression ISO Bilirubin results in decreased expression of PIK3R1 mRNA CTD PMID:20196124 NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:34,612,946...34,626,347 		JBrowse link
G Pla1a phospholipase A1 member A decreases expression ISO Bilirubin results in decreased expression of PLA1A mRNA CTD PMID:20196124 NCBI chr11:62,320,112...62,357,779
Ensembl chr11:75,825,585...75,878,165 		JBrowse link
G Pmp22 peripheral myelin protein 22 decreases expression ISO Bilirubin results in decreased expression of PMP22 mRNA CTD PMID:20196124 NCBI chr10:48,294,932...48,324,941
Ensembl chr10:48,297,437...48,324,940 		JBrowse link
G Pon2 paraoxonase 2 decreases expression ISO Bilirubin results in decreased expression of PON2 mRNA CTD PMID:20196124 NCBI chr 4:34,356,270...34,391,684
Ensembl chr 4:34,356,274...34,391,996 		JBrowse link
G Prdx4 peroxiredoxin 4 decreases expression ISO Bilirubin results in decreased expression of PRDX4 mRNA CTD PMID:20196124 NCBI chr  X:43,876,374...43,893,815
Ensembl chr  X:43,876,417...43,893,812 		JBrowse link
G Pten phosphatase and tensin homolog multiple interactions ISO Bilirubin inhibits the reaction [IL18 protein results in increased expression of PTEN protein] CTD PMID:18215737 NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:240,043,707...240,110,330 		JBrowse link
G Rassf4 Ras association domain family member 4 increases expression ISO Bilirubin results in increased expression of RASSF4 mRNA CTD PMID:20196124 NCBI chr 4:149,897,525...149,932,658
Ensembl chr 4:151,569,984...151,604,883 		JBrowse link
G Rbm39 RNA binding motif protein 39 decreases expression ISO Bilirubin results in decreased expression of RBM39 mRNA CTD PMID:20196124 NCBI chr 3:144,662,998...144,696,222
Ensembl chr 3:165,123,095...165,149,397 		JBrowse link
G Rbm5 RNA binding motif protein 5 decreases expression ISO Bilirubin results in decreased expression of RBM5 mRNA CTD PMID:20196124 NCBI chr 8:108,420,220...108,449,481
Ensembl chr 8:117,299,084...117,327,706 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases expression ISO Bilirubin results in increased expression of RELA mRNA CTD PMID:27578021 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Rhobtb3 Rho-related BTB domain containing 3 decreases expression ISO Bilirubin results in decreased expression of RHOBTB3 mRNA CTD PMID:20196124 NCBI chr 2:5,363,388...5,419,164
Ensembl chr 2:7,095,253...7,150,906 		JBrowse link
G Rnase4 ribonuclease A family member 4 decreases expression ISO Bilirubin results in decreased expression of RNASE4 mRNA CTD PMID:20196124 NCBI chr15:24,312,765...24,330,112
Ensembl chr15:26,786,079...26,803,639 		JBrowse link
G Runx2 RUNX family transcription factor 2 decreases expression EXP Bilirubin results in decreased expression of RUNX2 mRNA CTD PMID:20020468 NCBI chr 9:23,661,278...23,990,248
Ensembl chr 9:23,664,952...23,990,027 		JBrowse link
G S100a10 S100 calcium binding protein A10 decreases expression ISO Bilirubin results in decreased expression of S100A10 mRNA CTD PMID:20196124 NCBI chr 2:181,904,454...181,913,101
Ensembl chr 2:181,904,261...181,913,103 		JBrowse link
G S100a4 S100 calcium-binding protein A4 decreases expression ISO Bilirubin results in decreased expression of S100A4 mRNA CTD PMID:20196124 NCBI chr 2:178,388,529...178,390,838
Ensembl chr 2:178,388,526...178,390,837 		JBrowse link
G Scp2 sterol carrier protein 2 decreases expression ISO Bilirubin results in decreased expression of SCP2 mRNA CTD PMID:20196124 NCBI chr 5:128,035,714...128,110,015
Ensembl chr 5:128,008,125...128,110,043 		JBrowse link
G Selenbp1 selenium binding protein 1 decreases expression ISO Bilirubin results in decreased expression of SELENBP1 mRNA CTD PMID:20196124 NCBI chr 2:185,183,022...185,193,612
Ensembl chr 2:185,183,004...185,194,295 		JBrowse link
G Serpinb1a serpin family B member 1A decreases expression ISO Bilirubin results in decreased expression of SERPINB1A mRNA CTD PMID:20196124 NCBI chr17:31,799,446...31,807,853
Ensembl chr17:31,799,415...31,808,166 		JBrowse link
G Serpine1 serpin family E member 1 increases expression ISO Bilirubin results in increased expression of SERPINE1 mRNA CTD PMID:20196124 NCBI chr12:25,237,977...25,248,356
Ensembl chr12:25,237,952...25,248,357 		JBrowse link
G Sesn1 sestrin 1 decreases expression ISO Bilirubin results in decreased expression of SESN1 mRNA CTD PMID:20196124 NCBI chr20:45,294,876...45,387,698
Ensembl chr20:46,876,895...46,970,010 		JBrowse link
G Sgpp1 sphingosine-1-phosphate phosphatase 1 decreases expression ISO Bilirubin results in decreased expression of SGPP1 mRNA CTD PMID:20196124 NCBI chr 6:100,161,024...100,182,214
Ensembl chr 6:100,161,024...100,182,259 		JBrowse link
G Slc16a12 solute carrier family 16, member 12 decreases expression ISO Bilirubin results in decreased expression of SLC16A12 mRNA CTD PMID:20196124 NCBI chr 1:241,597,165...241,674,821
Ensembl chr 1:241,599,066...241,674,743 		JBrowse link
G Slc23a1 solute carrier family 23 member 1 increases expression ISO Bilirubin results in increased expression of SLC23A1 mRNA CTD PMID:18706437 NCBI chr18:27,490,549...27,504,563
Ensembl chr18:27,490,374...27,504,702 		JBrowse link
G Slc23a2 solute carrier family 23 member 2 increases expression ISO Bilirubin results in increased expression of SLC23A2 mRNA CTD PMID:18706437 NCBI chr 3:139,755,583...139,913,304
Ensembl chr 3:139,755,584...139,847,343 		JBrowse link
G Slc3a2 solute carrier family 3 member 2 multiple interactions
increases expression 		ISO [[[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione] which results in decreased susceptibility to Hydrogen Peroxide; [[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione; [Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine; Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]
Bilirubin results in increased expression of SLC3A2 mRNA 		CTD PMID:22216172 NCBI chr 1:215,033,601...215,048,064
Ensembl chr 1:215,033,601...215,048,064 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 multiple interactions
increases expression 		ISO [[[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione] which results in decreased susceptibility to Hydrogen Peroxide; [[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione; [Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine; Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]
Bilirubin results in increased expression of SLC7A11 mRNA 		CTD PMID:22216172 NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:136,532,246...136,695,695 		JBrowse link
G Snx14 sorting nexin 14 decreases expression ISO Bilirubin results in decreased expression of SNX14 mRNA CTD PMID:20196124 NCBI chr 8:89,283,673...89,390,597
Ensembl chr 8:98,186,714...98,270,451 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP Bilirubin inhibits the reaction [Aminolevulinic Acid results in decreased activity of SOD1 protein] CTD PMID:12853123 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399 		JBrowse link
G Sost sclerostin decreases expression ISO Bilirubin results in decreased expression of SOST mRNA CTD PMID:20196124 NCBI chr10:86,912,517...86,915,561
Ensembl chr10:87,411,721...87,415,766 		JBrowse link
G Sp5 Sp5 transcription factor decreases expression ISO Bilirubin results in decreased expression of SP5 mRNA CTD PMID:20196124 NCBI chr 3:55,274,931...55,277,733
Ensembl chr 3:75,682,677...75,685,479 		JBrowse link
G Tapbp TAP binding protein decreases expression ISO Bilirubin results in decreased expression of TAPBP mRNA CTD PMID:20196124 NCBI chr20:4,958,821...4,967,958
Ensembl chr20:4,959,926...4,971,834 		JBrowse link
G Tcf4 transcription factor 4 decreases expression ISO Bilirubin results in decreased expression of TCF4 mRNA CTD PMID:20196124 NCBI chr18:65,216,840...65,563,186
Ensembl chr18:65,216,849...65,558,401 		JBrowse link
G Tet1 tet methylcytosine dioxygenase 1 decreases expression EXP Bilirubin results in decreased expression of TET1 mRNA; Bilirubin results in decreased expression of TET1 protein CTD PMID:28805483 NCBI chr20:25,761,042...25,840,926
Ensembl chr20:25,760,057...25,832,730 		JBrowse link
G Tiparp TCDD-inducible poly(ADP-ribose) polymerase increases expression ISO Bilirubin results in increased expression of TIPARP mRNA CTD PMID:20196124 NCBI chr 2:149,753,682...149,780,327
Ensembl chr 2:152,063,751...152,090,406 		JBrowse link
G Tm9sf2 transmembrane 9 superfamily member 2 decreases expression ISO Bilirubin results in decreased expression of TM9SF2 mRNA CTD PMID:20196124 NCBI chr15:105,606,082...105,660,715
Ensembl chr15:105,606,118...105,660,714 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression 		ISO 4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased expression of TNF mRNA]
Bilirubin results in increased expression of TNF mRNA; Bilirubin results in increased expression of TNF protein 		CTD PMID:27578021 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Tnfrsf19 TNF receptor superfamily member 19 decreases expression ISO Bilirubin results in decreased expression of TNFRSF19 mRNA CTD PMID:20196124 NCBI chr15:39,268,305...39,334,566
Ensembl chr15:39,268,305...39,356,438 		JBrowse link
G Tpp1 tripeptidyl peptidase 1 decreases expression ISO Bilirubin results in decreased expression of TPP1 mRNA CTD PMID:20196124 NCBI chr 1:169,509,816...169,515,939
Ensembl chr 1:169,509,815...169,516,024 		JBrowse link
G Trib2 tribbles pseudokinase 2 decreases expression ISO Bilirubin results in decreased expression of TRIB2 mRNA CTD PMID:20196124 NCBI chr 6:44,274,762...44,299,139
Ensembl chr 6:44,274,762...44,299,094 		JBrowse link
G Ube2i ubiquitin-conjugating enzyme E2I decreases expression ISO Bilirubin results in decreased expression of UBE2I mRNA CTD PMID:20196124 NCBI chr10:14,782,245...14,802,911
Ensembl chr10:70,199,041...70,199,866
Ensembl chr10:70,199,041...70,199,866 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression
decreases activity
multiple interactions
decreases glucuronidation
increases glucuronidation
increases metabolic processing 		ISO
EXP 		Bilirubin results in increased expression of UGT1A1 mRNA
Bilirubin results in decreased activity of UGT1A1 protein
5-methoxypsoralen promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]; chrysin promotes the reaction [UGT1A1 protein affects the glucuronidation of Bilirubin]; chrysin promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]; Coumarins analog promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]; IL1B protein inhibits the reaction [Bilirubin results in increased expression of UGT1A1 mRNA]; imperatorin promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]; UGT1A1 protein results in increased glucuronidation of and results in decreased activity of Bilirubin
UGT1A1 gene mutant form results in decreased glucuronidation of Bilirubin
UGT1A1 protein results in increased glucuronidation of Bilirubin; UGT1A1 results in increased glucuronidation of Bilirubin
UGT1A1 protein results in increased metabolism of Bilirubin
5-methoxypsoralen promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]; chrysin promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]; Coumarins analog promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]; imperatorin promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin] 		CTD PMID:10950852 PMID:12153725 PMID:15334623 PMID:15382119 PMID:15557560 More... NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 decreases activity ISO Bilirubin results in decreased activity of UGT1A3 protein CTD PMID:15334623 NCBI chr 9:96,239,019...96,256,264
Ensembl chr 9:96,144,786...96,256,264 		JBrowse link
G Uqcr11 ubiquinol-cytochrome c reductase, complex III subunit XI decreases expression ISO Bilirubin results in decreased expression of UQCR11 mRNA CTD PMID:20196124 NCBI chr 7:9,955,717...9,960,432
Ensembl chr 7:9,955,764...9,959,047 		JBrowse link
G Uqcrb ubiquinol-cytochrome c reductase binding protein decreases expression ISO Bilirubin results in decreased expression of UQCRB mRNA CTD PMID:20196124 NCBI chr 7:63,814,784...63,820,150
Ensembl chr 7:65,700,029...65,705,558 		JBrowse link
G Uqcrc1 ubiquinol-cytochrome c reductase core protein 1 decreases expression ISO Bilirubin results in decreased expression of UQCRC1 mRNA CTD PMID:20196124 NCBI chr 8:109,589,735...109,601,481
Ensembl chr 8:118,468,200...118,479,964 		JBrowse link
G Uqcrh ubiquinol-cytochrome c reductase hinge protein decreases expression ISO Bilirubin results in decreased expression of UQCRH mRNA CTD PMID:20196124 NCBI chr 5:129,545,978...129,554,173
Ensembl chr 5:134,782,255...134,790,926 		JBrowse link
G Uxs1 UDP-glucuronate decarboxylase 1 decreases expression ISO Bilirubin results in decreased expression of UXS1 mRNA CTD PMID:20196124 NCBI chr 9:740,929...818,310
Ensembl chr 9:740,724...818,319 		JBrowse link
G Vldlr very low density lipoprotein receptor decreases expression ISO Bilirubin results in decreased expression of VLDLR mRNA CTD PMID:20196124 NCBI chr 1:234,239,769...234,272,150
Ensembl chr 1:234,240,121...234,272,154 		JBrowse link
G Vwf von Willebrand factor multiple interactions ISO [VWF protein affects the susceptibility to 1-Naphthylisothiocyanate] which affects the abundance of Bilirubin CTD PMID:34619301 NCBI chr 4:160,042,900...160,177,757
Ensembl chr 4:160,047,982...160,177,757 		JBrowse link
G Xbp1 X-box binding protein 1 increases expression
multiple interactions 		ISO
EXP 		Bilirubin results in increased expression of XBP1 mRNA
4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased expression of XBP1 mRNA]
Bilirubin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of XBP1 mRNA alternative form] 		CTD PMID:27578021 PMID:37054934 NCBI chr14:84,604,623...84,609,707
Ensembl chr14:84,604,107...84,609,706 		JBrowse link
G Zbtb20 zinc finger and BTB domain containing 20 decreases expression ISO Bilirubin results in decreased expression of ZBTB20 mRNA CTD PMID:20196124 NCBI chr11:70,558,010...71,297,039
Ensembl chr11:70,580,930...70,736,237 		JBrowse link
G Zbtb8os zinc finger and BTB domain containing 8 opposite strand decreases expression ISO Bilirubin results in decreased expression of ZBTB8OS mRNA CTD PMID:20196124 NCBI chr 5:141,675,595...141,687,148
Ensembl chr 5:146,959,843...147,010,497 		JBrowse link
G Zcchc7 zinc finger CCHC-type containing 7 decreases expression ISO Bilirubin results in decreased expression of ZCCHC7 mRNA CTD PMID:20196124 NCBI chr 5:63,787,292...63,968,960
Ensembl chr 5:63,788,217...63,968,549 		JBrowse link
G Zfand2a zinc finger AN1-type containing 2A increases expression ISO Bilirubin results in increased expression of ZFAND2A mRNA CTD PMID:20196124 NCBI chr12:15,161,601...15,172,679
Ensembl chr12:20,275,450...20,286,513 		JBrowse link
G Zfp207 zinc finger protein 207 decreases expression ISO Bilirubin results in decreased expression of ZFP207 mRNA CTD PMID:20196124 NCBI chr10:65,883,630...65,895,895
Ensembl chr10:65,883,599...65,895,895 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    chemical entity 20860
      group 20803
        24G7 epitope 177
          bilirubin IXalpha 177
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            organic molecule 20654
                              organic cyclic compound 20404
                                organic heterocyclic compound 19388
                                  organonitrogen heterocyclic compound 18546
                                    polypyrrole 711
                                      tetrapyrrole 599
                                        linear tetrapyrrole 179
                                          biladienes 177
                                            bilirubin IXalpha 177
paths to the root