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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:1H-indole
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Accession:CHEBI:16881 term browser browse the term
Definition:An indole that has formula C8H7N.
Synonyms:related_synonym: 2,3-Benzopyrrole;   Formula=C8H7N;   InChI=1S/C8H7N/c1-2-4-8-7(3-1)5-6-9-8/h1-6,9H;   InChIKey=SIKJAQJRHWYJAI-UHFFFAOYSA-N;   Indol;   SMILES=c1cc2ccccc2[nH]1;   indole
 alt_id: CHEBI:14444;   CHEBI:24794;   CHEBI:43537;   CHEBI:5900
 xref: Beilstein:107693;   CAS:120-72-9;   DrugBank:DB04532;   Gmelin:3477;   KEGG:C00463;   KNApSAcK:C00001418
 xref_mesh: MESH:C030374
 xref: PDBeChem:IND
 cyclic_relationship: is_tautomer_of CHEBI:35579


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1H-indole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression
multiple interactions		 ISO indole results in increased expression of ABCB1 mRNA
indole promotes the reaction [NR1I2 protein binds to ABCB1 promoter]; NR1I2 protein promotes the reaction [indole results in increased expression of ABCB1 mRNA]		 CTD PMID:33002526 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO indole binds to and results in increased activity of AHR protein; indole results in increased activity of [AHR protein binds to ARNT protein] CTD PMID:9407059 PMID:28186253 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions ISO indole results in increased activity of [AHR protein binds to ARNT protein] CTD PMID:9407059 NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
increases expression		 ISO NR1I2 protein promotes the reaction [indole results in increased expression of CYP3A4 mRNA] CTD PMID:33002526 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Epo erythropoietin multiple interactions EXP indole inhibits the reaction [cobaltous chloride results in increased expression of EPO mRNA]; indole inhibits the reaction [cobaltous chloride results in increased expression of EPO protein] CTD PMID:21863063 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946 		JBrowse link
G Mc1r melanocortin 1 receptor affects binding ISO indole analog binds to MC1R protein CTD PMID:11909711 NCBI chr19:51,452,448...51,455,375
Ensembl chr19:51,453,239...51,454,192 		JBrowse link
G Mc3r melanocortin 3 receptor affects binding ISO indole analog binds to MC3R protein CTD PMID:11909711 NCBI chr 3:161,016,347...161,017,444
Ensembl chr 3:161,016,347...161,017,444 		JBrowse link
G Mc4r melanocortin 4 receptor affects binding ISO indole analog binds to MC4R protein CTD PMID:11909711 NCBI chr18:60,419,832...60,421,719
Ensembl chr18:60,419,832...60,421,719 		JBrowse link
G Mc5r melanocortin 5 receptor affects binding ISO indole analog binds to MC5R protein CTD PMID:11909711 NCBI chr18:61,915,188...61,920,229
Ensembl chr18:61,915,188...61,920,229 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO indole binds to and results in increased activity of NR1I2 protein; indole promotes the reaction [NR1I2 protein binds to ABCB1 promoter]; NR1I2 protein promotes the reaction [indole results in increased expression of ABCB1 mRNA]; NR1I2 protein promotes the reaction [indole results in increased expression of CYP3A4 mRNA] CTD PMID:33002526 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
2-methyl-1H-indole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression ISO 2-methylindole results in increased expression of ABCB1 mRNA CTD PMID:32092453 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions		 ISO 2-methylindole results in increased expression of CYP1A1 protein
2-methylindole inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]		 CTD PMID:31201936 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO 2-methylindole results in increased expression of CYP1A2 protein CTD PMID:31201936 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression
multiple interactions		 ISO 2-methylindole results in increased expression of CYP3A4 mRNA
NR1I2 protein affects the reaction [2-methylindole results in increased expression of CYP3A4 mRNA]		 CTD PMID:32092453 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 affects binding
increases expression
multiple interactions		 ISO 2-methylindole binds to NR1I2 protein
2-methylindole results in increased expression of NR1I2 mRNA
NR1I2 protein affects the reaction [2-methylindole results in increased expression of CYP3A4 mRNA]		 CTD PMID:32092453 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19922
    chemical entity 19920
      molecular entity 19920
        mancude ring 11173
          organic mancude parent 11185
            mancude organic heterocyclic parent 11185
              mancude organic heterobicyclic parent 8326
                indole 12
                  1H-indole 12
                    (R)-3-(5-benzyloxyindol-3-yl)lactic acid 0
                    (R)-indole-3-lactic acid 0
                    2-methyl-1H-indole 5
                    5-isoprenylindole-3-carboxylate beta-D-glycosyl ester 0
                    N-(beta-D-glucopyranosyl)indole 0
                    xenocyloin + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19922
    subatomic particle 19892
      composite particle 19892
        hadron 19920
          baryon 19892
            nucleon 19920
              atomic nucleus 19892
                atom 19892
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19805
                        carbon atom 19802
                          organic molecular entity 19775
                            organic molecule 19755
                              organic cyclic compound 19545
                                organic heterocyclic compound 18906
                                  organic heteropolycyclic compound 18314
                                    organic heterobicyclic compound 17251
                                      benzopyrrole 9728
                                        indoles 9421
                                          indole 12
                                            1H-indole 12
                                              (R)-3-(5-benzyloxyindol-3-yl)lactic acid 0
                                              (R)-indole-3-lactic acid 0
                                              2-methyl-1H-indole 5
                                              5-isoprenylindole-3-carboxylate beta-D-glycosyl ester 0
                                              N-(beta-D-glucopyranosyl)indole 0
                                              xenocyloin + 0
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