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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:alizarin
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Accession:CHEBI:16866 term browser browse the term
Definition:A dihydroxyanthraquinone that is anthracene-9,10-dione in which the two hydroxy groups are located at positions 1 and 2.
Synonyms:related_synonym: 1,2-Anthraquinonediol;   1,2-Dihydroxyanthraquinone;   1,2-dihydroxy-9,10-anthraquinone;   1,2-dihydroxyanthra-9,10-quinone;   1,2-dihydroxyanthracene-9,10-dione;   Alizarin B;   Alizarin Red;   Az;   C.I. 58000;   Dihydroxy-9,10-anthracenedione;   Dihydroxyanthraquinone;   Mordant Red 11;   Turkey Red;   pigment red 83
 alt_id: CHEBI:13756;   CHEBI:22312;   CHEBI:2574;   CHEBI:87354
 xref: CAS:72-48-0;   Gmelin:34541;   KNApSAcK:C00002785
 xref_mesh: MESH:C010078
 xref: Reaxys:1914037;   kegg.compound:C01474;   lincs.smallmolecule:LSM-25636;   metacyc.compound:ALIZARIN;   pubmed:14500876;   pubmed:1650428;   pubmed:16851024;   pubmed:23225693;   pubmed:25025314;   pubmed:25497981;   pubmed:25651191;   pubmed:26178874;   pubmed:26763935;   wikipedia.en:Alizarin
 chemrof_formula: C14H8O4
 chemrof_inchi: InChI=1S/C14H8O4/c15-10-6-5-9-11(14(10)18)13(17)8-4-2-1-3-7(8)12(9)16/h1-6,15,18H
 chemrof_smiles: O=C1c2ccccc2C(=O)c2c1ccc(O)c2O
 chemrof_inchikey: RGCKGOZRHPZPFP-UHFFFAOYSA-N


show annotations for term's descendants           Sort by:
alizarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity
multiple interactions 		ISO alizarin results in decreased activity of CYP1A1 protein
alizarin affects the reaction [Benzo(a)pyrene affects the activity of CYP1A1 protein] 		CTD PMID:12379470 PMID:37515497 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO alizarin results in decreased activity of CYP1A2 protein CTD PMID:12379470 PMID:33438235 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO alizarin results in decreased activity of CYP1B1 protein CTD PMID:12379470 NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO alizarin results in decreased activity of CYP2E1 protein CTD PMID:12379470 NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO alizarin binds to and results in increased activity of ESR1 protein CTD PMID:20707409 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354 		JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO alizarin inhibits the reaction [Benzo(a)pyrene results in increased expression of H2AX protein] CTD PMID:37515497 NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:53,568,281...53,573,079 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO
EXP 		alizarin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK1 protein]; alizarin inhibits the reaction [Indican results in increased phosphorylation of MAPK1 protein] CTD PMID:33421718 PMID:38670245 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO alizarin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK3 protein] CTD PMID:33421718 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming multiple interactions ISO alizarin inhibits the reaction [Benzo(a)pyrene results in increased expression of MUC5AC mRNA]; alizarin inhibits the reaction [Benzo(a)pyrene results in increased expression of MUC5AC protein] CTD PMID:33421718 NCBI chr 1:206,293,717...206,326,006
Ensembl chr 1:206,293,869...206,326,006 		JBrowse link
G Nat1 N-acetyltransferase 1 decreases activity ISO alizarin results in decreased activity of NAT1 protein CTD PMID:34783865 NCBI chr16:26,984,882...27,005,194
Ensembl chr16:26,982,625...26,986,527 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of alizarin CTD PMID:14557274 NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of alizarin CTD PMID:14557274 NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:96,144,786...96,256,264 		JBrowse link
G Ugt2b15 UDP glucuronosyltransferase family 2 member B15 increases metabolic processing EXP UGT2B15 protein results in increased metabolism of alizarin CTD PMID:7574722 NCBI chr14:21,122,866...21,138,450
Ensembl chr14:21,122,861...21,138,467 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    role 20844
      application 20572
        dye 3036
          alizarin 13
Path 2
Term Annotations click to browse term
  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    p-block element atom 20796
                      carbon group element atom 20712
                        carbon atom 20706
                          organic molecular entity 20706
                            heteroorganic entity 20201
                              organochalcogen compound 19822
                                organooxygen compound 19713
                                  carbonyl compound 18827
                                    ketone 17484
                                      cyclic ketone 16169
                                        quinone 10438
                                          acenoquinone 8425
                                            anthraquinone 530
                                              hydroxyanthraquinones 518
                                                dihydroxyanthraquinone 357
                                                  alizarin 13
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