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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:alizarin
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Accession:CHEBI:16866 term browser browse the term
Definition:A dihydroxyanthraquinone that is anthracene-9,10-dione in which the two hydroxy groups are located at positions 1 and 2.
Synonyms:exact_synonym: 1,2-dihydroxyanthracene-9,10-dione
 related_synonym: 1,2-Anthraquinonediol;   1,2-Dihydroxyanthraquinone;   1,2-dihydroxy-9,10-anthraquinone;   1,2-dihydroxyanthra-9,10-quinone;   Alizarin B;   Alizarin Red;   Az;   C.I. 58000;   Dihydroxy-9,10-anthracenedione;   Dihydroxyanthraquinone;   Formula=C14H8O4;   InChI=1S/C14H8O4/c15-10-6-5-9-11(14(10)18)13(17)8-4-2-1-3-7(8)12(9)16/h1-6,15,18H;   InChIKey=RGCKGOZRHPZPFP-UHFFFAOYSA-N;   Mordant Red 11;   SMILES=Oc1ccc2C(=O)c3ccccc3C(=O)c2c1O;   Turkey Red;   pigment red 83
 alt_id: CHEBI:13756;   CHEBI:22312;   CHEBI:2574;   CHEBI:87354
 xref: CAS:72-48-0;   Gmelin:34541;   KEGG:C01474;   KNApSAcK:C00002785;   LINCS:LSM-25636
 xref_mesh: MESH:C010078
 xref: MetaCyc:ALIZARIN;   PMID:14500876;   PMID:1650428;   PMID:16851024;   PMID:23225693;   PMID:25025314;   PMID:25497981;   PMID:25651191;   PMID:26178874;   PMID:26763935;   Reaxys:1914037;   Wikipedia:Alizarin


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alizarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity
multiple interactions		 ISO alizarin results in decreased activity of CYP1A1 protein
alizarin affects the reaction [Benzo(a)pyrene affects the activity of CYP1A1 protein]		 CTD PMID:12379470 PMID:37515497 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO alizarin results in decreased activity of CYP1A2 protein CTD PMID:12379470 PMID:33438235 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO alizarin results in decreased activity of CYP1B1 protein CTD PMID:12379470 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO alizarin results in decreased activity of CYP2E1 protein CTD PMID:12379470 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO alizarin binds to and results in increased activity of ESR1 protein CTD PMID:20707409 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO alizarin inhibits the reaction [Benzo(a)pyrene results in increased expression of H2AX protein] CTD PMID:37515497 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO
EXP		 alizarin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK1 protein]; alizarin inhibits the reaction [Indican results in increased phosphorylation of MAPK1 protein] CTD PMID:33421718 PMID:38670245 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO alizarin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK3 protein] CTD PMID:33421718 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming multiple interactions ISO alizarin inhibits the reaction [Benzo(a)pyrene results in increased expression of MUC5AC mRNA]; alizarin inhibits the reaction [Benzo(a)pyrene results in increased expression of MUC5AC protein] CTD PMID:33421718 NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475 		JBrowse link
G Nat1 N-acetyltransferase 1 decreases activity ISO alizarin results in decreased activity of NAT1 protein CTD PMID:34783865 NCBI chr16:22,218,217...22,238,516
Ensembl chr16:22,208,194...22,238,520 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of alizarin CTD PMID:14557274 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of alizarin CTD PMID:14557274 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt2b15 UDP glucuronosyltransferase family 2 member B15 increases metabolic processing EXP UGT2B15 protein results in increased metabolism of alizarin CTD PMID:7574722 NCBI chr14:20,768,015...20,783,599
Ensembl chr14:20,768,015...20,783,589 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      application 19695
        dye 3004
          alizarin 13
            1-hydroxy-2-(beta-D-glucosyloxy)-9,10-anthraquinone 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      carbon group element atom 19757
                        carbon atom 19754
                          organic molecular entity 19754
                            heteroorganic entity 19512
                              organochalcogen compound 19275
                                organooxygen compound 19191
                                  carbonyl compound 18914
                                    ketone 17263
                                      cyclic ketone 15911
                                        quinone 9903
                                          acenoquinone 7725
                                            anthraquinone 518
                                              hydroxyanthraquinones 506
                                                dihydroxyanthraquinone 354
                                                  alizarin 13
                                                    1-hydroxy-2-(beta-D-glucosyloxy)-9,10-anthraquinone 0
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