Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:L-tryptophan
go back to main search page
Accession:CHEBI:16828 term browser browse the term
Definition:The L-enantiomer of tryptophan.
Synonyms:related_synonym: (2S)-2-amino-3-(1H-indol-3-yl)propanoic acid;   (S)-alpha-Amino-beta-(3-indolyl)-propionic acid;   (S)-alpha-amino-1H-indole-3-propanoic acid;   (S)-tryptophan;   Formula=C11H12N2O2;   InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1;   InChIKey=QIVBCDIJIAJPQS-VIFPVBQESA-N;   L-beta-3-indolylalanine;   SMILES=N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O;   Trp;   W;   tryptophan
 alt_id: CHEBI:13178;   CHEBI:184633;   CHEBI:21407;   CHEBI:45988;   CHEBI:46086;   CHEBI:46125;   CHEBI:46225;   CHEBI:6310
 xref: Beilstein:86197;   CAS:73-22-3;   DrugBank:DB00150;   Drug_Central:2780;   ECMDB:ECMDB00929;   Gmelin:51434;   HMDB:HMDB0000929;   KEGG:C00078;   KEGG:D00020;   KNApSAcK:C00001396
 xref_mesh: MESH:D014364
 xref: MetaCyc:TRP;   PDBeChem:TRP;   PMID:11395471;   PMID:11750787;   PMID:11888576;   PMID:12766158;   PMID:12830226;   PMID:12871129;   PMID:15206750;   PMID:16740930;   PMID:16934873;   PMID:17127472;   PMID:17177562;   PMID:17430113;   PMID:17585690;   PMID:17690425;   PMID:17826001;   PMID:18234569;   PMID:18419734;   PMID:18949702;   PMID:19896323;   PMID:21856896;   PMID:22071091;   PMID:22162421;   PMID:22299628;   PMID:22386992;   PMID:22402312;   PMID:22415302;   PMID:22415306;   PMID:2917974;   Reaxys:86197;   Wikipedia:Tryptophan;   YMDB:YMDB00126
 cyclic_relationship: is_conjugate_acid_of CHEBI:32702;   is_conjugate_base_of CHEBI:32704;   is_enantiomer_of CHEBI:16296;   is_tautomer_of CHEBI:57912


show annotations for term's descendants           Sort by:
L-tryptophan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor increases expression ISO Tryptophan results in increased expression of AHR mRNA CTD PMID:32781018 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G App amyloid beta precursor protein multiple interactions
decreases abundance		 ISO PF-06840003 inhibits the reaction [APP protein mutant form results in decreased abundance of Tryptophan] CTD PMID:39172838 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression		 ISO 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [[Tryptophan co-treated with [Medroxyprogesterone Acetate co-treated with Cyclic AMP]] results in increased expression of CYP1A1 mRNA]; [Tryptophan co-treated with [Medroxyprogesterone Acetate co-treated with Cyclic AMP]] results in increased expression of CYP1A1 mRNA
Tryptophan results in increased expression of CYP1A1 mRNA		 CTD PMID:32781018 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
increases expression		 ISO 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [[Tryptophan co-treated with [Medroxyprogesterone Acetate co-treated with Cyclic AMP]] results in increased expression of CYP1B1 mRNA]; [Tryptophan co-treated with [Medroxyprogesterone Acetate co-treated with Cyclic AMP]] results in increased expression of CYP1B1 mRNA
Tryptophan results in increased expression of CYP1B1 mRNA		 CTD PMID:32781018 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 increases expression
increases abundance		 ISO Tryptophan results in increased expression of IDO1 protein
IDO1 gene mutant form results in increased abundance of Tryptophan		 CTD PMID:32781018 PMID:32871117 NCBI chr16:67,430,654...67,442,726
Ensembl chr16:67,430,578...67,442,730 		JBrowse link
G Ifng interferon gamma multiple interactions ISO IFNG protein promotes the reaction [Tryptophan promotes the reaction [[Medroxyprogesterone Acetate co-treated with Cyclic AMP] results in increased expression of IGFBP1 mRNA]]; IFNG protein promotes the reaction [Tryptophan promotes the reaction [[Medroxyprogesterone Acetate co-treated with Cyclic AMP] results in increased expression of PRL mRNA]] CTD PMID:32781018 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 increases expression
multiple interactions		 ISO Tryptophan results in increased expression of IGFBP1 mRNA
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tryptophan promotes the reaction [[Medroxyprogesterone Acetate co-treated with Cyclic AMP] results in increased expression of IGFBP1 mRNA]]; IFNG protein promotes the reaction [Tryptophan promotes the reaction [[Medroxyprogesterone Acetate co-treated with Cyclic AMP] results in increased expression of IGFBP1 mRNA]]; Tryptophan promotes the reaction [[Medroxyprogesterone Acetate co-treated with Cyclic AMP] results in increased expression of IGFBP1 mRNA]		 CTD PMID:32781018 NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482 		JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO [amyloid beta-protein (1-42) binds to MAPT protein] which results in decreased abundance of Tryptophan
[amyloid beta-protein (1-42) binds to MAPT protein] which results in decreased abundance of Tryptophan; PF-06840003 inhibits the reaction [[amyloid beta-protein (1-42) binds to MAPT protein] which results in decreased abundance of Tryptophan]		 CTD PMID:39172838 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129 		JBrowse link
G Prl prolactin multiple interactions
increases expression		 ISO 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tryptophan promotes the reaction [[Medroxyprogesterone Acetate co-treated with Cyclic AMP] results in increased expression of PRL mRNA]]; IFNG protein promotes the reaction [Tryptophan promotes the reaction [[Medroxyprogesterone Acetate co-treated with Cyclic AMP] results in increased expression of PRL mRNA]]; Tryptophan promotes the reaction [[Medroxyprogesterone Acetate co-treated with Cyclic AMP] results in increased expression of PRL mRNA]
Tryptophan results in increased expression of PRL mRNA		 CTD PMID:32781018 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Slc7a5 solute carrier family 7 member 5 increases expression ISO Tryptophan results in increased expression of SLC7A5 mRNA CTD PMID:32781018 NCBI chr19:49,935,220...49,963,823
Ensembl chr19:49,935,220...49,963,823 		JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase increases abundance ISO TDO2 gene mutant form results in increased abundance of Tryptophan CTD PMID:32871117 NCBI chr 2:167,269,581...167,287,511
Ensembl chr 2:167,269,579...167,287,511 		JBrowse link
G Tph1 tryptophan hydroxylase 1 multiple interactions EXP [TPH1 protein results in increased hydroxylation of Tryptophan] which results in increased chemical synthesis of 5-Hydroxytryptophan CTD PMID:32243540 NCBI chr 1:97,157,375...97,178,415
Ensembl chr 1:97,157,409...97,178,344 		JBrowse link
ilomastat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il13 interleukin 13 multiple interactions EXP ilomastat inhibits the reaction [Mustard Gas results in increased expression of IL13 protein] CTD PMID:18852015 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737 		JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions EXP ilomastat affects the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MMP1 protein]; ilomastat inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MMP1 mRNA] CTD PMID:18837084 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP ilomastat affects the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TIMP1 mRNA]; ilomastat affects the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TIMP1 protein] CTD PMID:18837084 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
N-acetyl-L-tryptophan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions EXP N-acetyltryptophan inhibits the reaction [Aluminum Chloride results in decreased activity of ACHE protein] CTD PMID:29185389 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Casp2 caspase 2 multiple interactions ISO N-acetyltryptophan inhibits the reaction [Cobalt-60 results in increased activity of CASP2 protein] CTD PMID:37702290 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO N-acetyltryptophan inhibits the reaction [Cobalt-60 results in increased activity of CASP3 protein] CTD PMID:37702290 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO N-acetyltryptophan inhibits the reaction [Cobalt-60 results in increased activity of CASP9 protein] CTD PMID:37702290 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase multiple interactions ISO N-acetyltryptophan inhibits the reaction [Cobalt-60 results in decreased activity of CAT protein] CTD PMID:37702290 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Xdh xanthine dehydrogenase multiple interactions ISO N-acetyltryptophan inhibits the reaction [Cobalt-60 results in increased activity of XDH protein] CTD PMID:37702290 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268 		JBrowse link
violacein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp2 caspase 2 increases activity ISO violacein results in increased activity of CASP2 protein CTD PMID:20416285 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379 		JBrowse link
G Casp3 caspase 3 increases activity ISO violacein results in increased activity of CASP3 protein CTD PMID:20416285 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 increases activity ISO violacein results in increased activity of CASP9 protein CTD PMID:20416285 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    role 19854
      application 19722
        pharmaceutical 19556
          drug 19556
            nutraceutical 13390
              L-tryptophan 21
                (2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate 0
                1-L-tryptophano group 0
                5-methoxytryptophan 0
                Ala-Phe-Trp-Asn 0
                Ala-Trp-Asn-Asp 0
                Arg-Trp-Pro 0
                Arg-Trp-Ser-Tyr 0
                Asn-Met-Trp-Asn 0
                Asn-Trp 0
                Asn-Trp-Asp-Ser 0
                Asn-Trp-Cys-His 0
                Asp-Trp-Trp-Val 0
                Gln-Phe-Trp-Tyr 0
                Gln-Trp 0
                Glu-Ala-Trp 0
                Glu-Glu-Gln-Trp 0
                Glu-Gly-Trp 0
                Glu-Lys-Trp-Ala 0
                Glu-Trp 0
                Glu-Trp-Asp-Arg 0
                Ile-Leu-Trp-Trp 0
                L-tryptophan derivative + 9
                L-tryptophan residue + 0
                L-tryptophano group 0
                L-tryptophanyl radical + 0
                L-tryptophanyl radical cation + 0
                L-tryptophyl group 0
                Leu-Trp 0
                Lys-Ser-Trp 0
                Lys-Thr-Trp-Tyr 0
                Phe-Trp-Ala 0
                Phe-Trp-Trp 0
                Pro-Trp-Val-Gly 0
                Ser-Trp 0
                Ser-Trp-Lys 0
                Thr-Trp 0
                Thr-Trp-Asp 0
                Trp-Ala 0
                Trp-Ala-Asp 0
                Trp-Ala-Gly 0
                Trp-Asn 0
                Trp-Asp-Ser 0
                Trp-Ile 0
                Trp-Pro 0
                Trp-Ser 0
                Trp-Thr 0
                Trp-Trp 0
                Trp-Trp-Val 0
                cyclo-acetoacetyl-L-tryptophan(1-) 0
                notoamide + 0
                proviolacein + 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    main group molecular entity 19849
                      s-block molecular entity 19681
                        hydrogen molecular entity 19662
                          hydrides 19167
                            inorganic hydride 18182
                              pnictogen hydride 18172
                                nitrogen hydride 18085
                                  azane 17866
                                    ammonia 17865
                                      organic amino compound 17888
                                        amino acid 16071
                                          alpha-amino acid 13929
                                            L-alpha-amino acid 12971
                                              erythrose 4-phosphate/phosphoenolpyruvate family amino acid 2403
                                                L-tryptophan 21
                                                  (2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate 0
                                                  1-L-tryptophano group 0
                                                  5-methoxytryptophan 0
                                                  Ala-Phe-Trp-Asn 0
                                                  Ala-Trp-Asn-Asp 0
                                                  Arg-Trp-Pro 0
                                                  Arg-Trp-Ser-Tyr 0
                                                  Asn-Met-Trp-Asn 0
                                                  Asn-Trp 0
                                                  Asn-Trp-Asp-Ser 0
                                                  Asn-Trp-Cys-His 0
                                                  Asp-Trp-Trp-Val 0
                                                  Gln-Phe-Trp-Tyr 0
                                                  Gln-Trp 0
                                                  Glu-Ala-Trp 0
                                                  Glu-Glu-Gln-Trp 0
                                                  Glu-Gly-Trp 0
                                                  Glu-Lys-Trp-Ala 0
                                                  Glu-Trp 0
                                                  Glu-Trp-Asp-Arg 0
                                                  Ile-Leu-Trp-Trp 0
                                                  L-tryptophan derivative + 9
                                                  L-tryptophan residue + 0
                                                  L-tryptophano group 0
                                                  L-tryptophanyl radical + 0
                                                  L-tryptophanyl radical cation + 0
                                                  L-tryptophyl group 0
                                                  Leu-Trp 0
                                                  Lys-Ser-Trp 0
                                                  Lys-Thr-Trp-Tyr 0
                                                  Phe-Trp-Ala 0
                                                  Phe-Trp-Trp 0
                                                  Pro-Trp-Val-Gly 0
                                                  Ser-Trp 0
                                                  Ser-Trp-Lys 0
                                                  Thr-Trp 0
                                                  Thr-Trp-Asp 0
                                                  Trp-Ala 0
                                                  Trp-Ala-Asp 0
                                                  Trp-Ala-Gly 0
                                                  Trp-Asn 0
                                                  Trp-Asp-Ser 0
                                                  Trp-Ile 0
                                                  Trp-Pro 0
                                                  Trp-Ser 0
                                                  Trp-Thr 0
                                                  Trp-Trp 0
                                                  Trp-Trp-Val 0
                                                  cyclo-acetoacetyl-L-tryptophan(1-) 0
                                                  notoamide + 0
                                                  proviolacein + 3
paths to the root