Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:isorhapontigenin
go back to main search page
Accession:CHEBI:167830 term browser browse the term
Definition:A stilbenol that is trans-stilbene in which one of the phenyl groups is substituted by hydroxy groups at positions 3 and 5, while the other phenyl group is substituted by a methoxy group at position 3 and a hydroxy group at position 4. It natural product isolated from the seeds of Aiphanes aculeata and has antioxidant, anti-tumour, and anti-inflammatory effects.
Synonyms:exact_synonym: 5-[(E)-2-(4-hydroxy-3-methoxyphenyl)ethenyl]benzene-1,3-diol
 related_synonym: (E)-isorhapontigenin;   3'-methoxyresveratrol;   5-[(1E)-2-(4-hydroxy-3-methoxyphenyl)ethenyl]-1,3-benzenediol;   Formula=C15H14O4;   ISO;   InChI=1S/C15H14O4/c1-19-15-8-10(4-5-14(15)18)2-3-11-6-12(16)9-13(17)7-11/h2-9,16-18H,1H3/b3-2+;   InChIKey=ANNNBEZJTNCXHY-NSCUHMNNSA-N;   SMILES=COC1=C(O)C=CC(\\C=C\\C2=CC(O)=CC(O)=C2)=C1;   isorhapotigenin;   isorhapotogenin
 xref: Chemspider:4477172;   FooDB:FDB008478;   HMDB:HMDB0303171;   KNApSAcK:C00015797
 xref_mesh: MESH:C432307
 xref: MetaCyc:CPD-27168;   PMID:11440571;   PMID:31461638;   PMID:31512108;   PMID:32178518;   PMID:33777675;   PMID:33798789;   PMID:34102010;   PMID:34332039;   PMID:35532178;   PMID:35720190;   PMID:35960477;   PMID:36039137;   PMID:36045117;   PMID:36214721;   PMID:36325776;   PMID:36367849;   PMID:37619952;   PMID:37624928;   PMID:38002023;   PMID:38339062;   PMID:38728614;   PMID:38837389;   PMID:38879516;   PMID:39046236;   PMID:39067404;   PMID:39326106;   Wikipedia:Isorhapontigenin


show annotations for term's descendants           Sort by:
isorhapontigenin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen multiple interactions EXP isorhapontigenin inhibits the reaction [AGT protein results in increased abundance of Hydrogen Peroxide]; isorhapontigenin inhibits the reaction [AGT protein results in increased abundance of Malondialdehyde]; isorhapontigenin inhibits the reaction [AGT protein results in increased abundance of Reactive Oxygen Species]; isorhapontigenin inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]; isorhapontigenin inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]; isorhapontigenin inhibits the reaction [AGT protein results in increased phosphorylation of MAPK8 protein] CTD PMID:15607907 NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO isorhapontigenin results in decreased expression of CCND1 protein CTD PMID:37619952 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810 		JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO [sodium bichromate co-treated with isorhapontigenin] results in increased expression of CDH1 protein CTD PMID:37619952 NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO [sodium bichromate co-treated with isorhapontigenin] inhibits the reaction [CTNNB1 protein modified form binds to NEDD9 protein]; [sodium bichromate co-treated with isorhapontigenin] results in decreased localization of CTNNB1 protein; [sodium bichromate co-treated with isorhapontigenin] results in decreased phosphorylation of CTNNB1 protein CTD PMID:37619952 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662 		JBrowse link
G Dnmt1 DNA methyltransferase 1 multiple interactions ISO [sodium bichromate co-treated with isorhapontigenin] results in decreased expression of DNMT1 protein CTD PMID:37619952 NCBI chr 8:27,716,797...27,763,405
Ensembl chr 8:27,716,797...27,763,119 		JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha multiple interactions ISO [sodium bichromate co-treated with isorhapontigenin] results in decreased expression of DNMT3A protein CTD PMID:37619952 NCBI chr 6:32,507,316...32,621,678
Ensembl chr 6:32,512,070...32,614,970 		JBrowse link
G Dnmt3b DNA methyltransferase 3 beta multiple interactions ISO [sodium bichromate co-treated with isorhapontigenin] results in decreased expression of DNMT3B protein CTD PMID:37619952 NCBI chr 3:162,590,777...162,629,313
Ensembl chr 3:162,604,037...162,629,313 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit affects expression EXP isorhapontigenin affects the expression of FOS protein CTD PMID:15607907 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO [sodium bichromate co-treated with isorhapontigenin] results in increased phosphorylation of GSK3B protein CTD PMID:37619952 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta affects activity EXP isorhapontigenin affects the activity of IKBKB protein CTD PMID:15607907 NCBI chr16:76,021,968...76,075,717
Ensembl chr16:76,022,008...76,081,911 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit affects expression EXP isorhapontigenin affects the expression of JUN protein CTD PMID:15607907 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP isorhapontigenin inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein] CTD PMID:15607907 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP isorhapontigenin inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein] CTD PMID:15607907 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP isorhapontigenin inhibits the reaction [AGT protein results in increased phosphorylation of MAPK8 protein] CTD PMID:15607907 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427 		JBrowse link
G Meg3 maternally expressed 3 multiple interactions ISO isorhapontigenin inhibits the reaction [sodium bichromate results in decreased expression of MEG3] CTD PMID:37619952 NCBI chr 6:128,491,808...128,524,010 JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO isorhapontigenin results in decreased expression of MKI67 protein CTD PMID:37619952 NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:199,926,150...199,952,593 		JBrowse link
G Nedd9 neural precursor cell expressed, developmentally down-regulated 9 multiple interactions ISO [sodium bichromate co-treated with isorhapontigenin] inhibits the reaction [CTNNB1 protein modified form binds to NEDD9 protein]; [sodium bichromate co-treated with isorhapontigenin] results in decreased expression of and results in decreased localization of NEDD9 protein; [sodium bichromate co-treated with isorhapontigenin] results in decreased expression of NEDD9 mRNA CTD PMID:37619952 NCBI chr17:23,495,531...23,673,780
Ensembl chr17:23,495,492...23,675,668 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP isorhapontigenin affects the degradation of and affects the phosphorylation of NFKBIA protein CTD PMID:15607907 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G Snai2 snail family transcriptional repressor 2 multiple interactions ISO [sodium bichromate co-treated with isorhapontigenin] results in decreased expression of SNAI2 protein CTD PMID:37619952 NCBI chr11:99,686,934...99,690,349
Ensembl chr11:99,686,934...99,690,349 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      chemical role 20396
        antioxidant 16464
          isorhapontigenin 19
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            organic molecule 20654
                              organic cyclic compound 20404
                                carbocyclic compound 18974
                                  benzenoid aromatic compound 18458
                                    benzenes 18333
                                      methoxybenzenes 2995
                                        monomethoxybenzene 1994
                                          guaiacols 1396
                                            isorhapontigenin 19
paths to the root