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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:creatinine
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Accession:CHEBI:16737 term browser browse the term
Definition:A lactam obtained by formal cyclocondensation of creatine. It is a metabolite of creatine.
Synonyms:exact_synonym: 2-imino-1-methylimidazolidin-4-one
 related_synonym: 1-Methylhydantoin-2-imide;   1-methylglycocyamidine;   2-Amino-1-methylimidazolin-4-one;   2-amino-1,5-dihydro-1-methyl-4H-Imidazol-4-one;   Creatine anhydride;   Formula=C4H7N3O;   InChI=1S/C4H7N3O/c1-7-2-3(8)6-4(7)5/h2H2,1H3,(H2,5,6,8);   InChIKey=DDRJAANPRJIHGJ-UHFFFAOYSA-N;   Kreatinin;   SMILES=CN1CC(=O)NC1=N;   creatinina
 alt_id: CHEBI:14029;   CHEBI:23406;   CHEBI:3910
 xref: CAS:60-27-5;   HMDB:HMDB0000562;   KEGG:C00791;   KEGG:D03600
 xref_mesh: MESH:D003404
 xref: MetaCyc:CREATININE;   PMID:11256540;   PMID:11981083;   PMID:17190852;   PMID:17422601;   PMID:18182718;   PMID:19236048;   PMID:19715855;   PMID:19968328;   PMID:21775764;   PMID:22047975;   PMID:22121923;   PMID:22166252;   PMID:22207347;   PMID:22212624;   PMID:22223530;   PMID:22331238;   PMID:22338083;   PMID:22349552;   PMID:22390548;   PMID:22432114;   PMID:22441184;   PMID:22459582;   PMID:22498455;   Reaxys:112064;   Wikipedia:Creatinine


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creatinine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmal1 basic helix-loop-helix ARNT like 1 increases abundance ISO BMAL1 gene mutant form results in increased abundance of Creatinine CTD PMID:27056296 NCBI chr 1:167,331,756...167,430,235
Ensembl chr 1:176,829,305...176,864,739 		JBrowse link
G Col2a1 collagen type II alpha 1 chain multiple interactions EXP [COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Creatinine; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Creatinine]; Dexamethasone inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Creatinine]; huang-lien-chieh-tu-tang inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Creatinine] CTD PMID:24709313 NCBI chr 7:130,977,561...131,006,627
Ensembl chr 7:130,977,561...131,006,627 		JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 multiple interactions
increases abundance 		ISO Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Creatinine] CTD PMID:27469509 NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:143,439,323...143,467,248 		JBrowse link
G Lepr leptin receptor affects abundance
increases abundance
multiple interactions 		ISO LEPR affects the abundance of Creatinine
LEPR gene mutant form results in increased abundance of Creatinine
Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased abundance of Creatinine]; swietenine inhibits the reaction [LEPR gene mutant form results in increased abundance of Creatinine] 		CTD PMID:20567778 PMID:29988851 PMID:36066211 NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:121,474,099...121,591,215 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO [NFE2L2 protein affects the susceptibility to ochratoxin A] which results in increased abundance of Creatinine CTD PMID:28710020 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 multiple interactions EXP [SC 560 results in decreased activity of PTGS1 protein] which results in increased abundance of Creatinine CTD PMID:19629487 NCBI chr 3:39,981,419...40,002,993
Ensembl chr 3:39,981,415...40,002,990 		JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Creatinine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,533,580...46,590,128
Ensembl chr10:46,533,583...46,587,096 		JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Creatinine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:45,990,806...46,033,937
Ensembl chr10:46,489,831...46,533,425 		JBrowse link
G Sod2 superoxide dismutase 2 decreases abundance ISO SOD2 protein results in decreased abundance of Creatinine CTD PMID:19917352 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      application 20621
        pharmaceutical 20416
          diagnostic agent 792
            creatinine 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    main group molecular entity 20781
                      s-block molecular entity 20574
                        hydrogen molecular entity 20558
                          hydrides 19693
                            inorganic hydride 18602
                              pnictogen hydride 18589
                                nitrogen hydride 18502
                                  azane 18262
                                    ammonia 18261
                                      organic amino compound 18261
                                        amino acid 16340
                                          alpha-amino acid 14255
                                            serine family amino acid 6105
                                              glycine 3485
                                                glycine derivative 3473
                                                  creatine 44
                                                    creatinine 9
paths to the root