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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:pyridoxine
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Accession:CHEBI:16709 term browser browse the term
Definition:A hydroxymethylpyridine with hydroxymethyl groups at positions 4 and 5, a hydroxy group at position 3 and a methyl group at position 2. The 4-methanol form of vitamin B6, it is converted intoto pyridoxal phosphate which is a coenzyme for synthesis of amino acids, neurotransmitters, sphingolipids and aminolevulinic acid.
Synonyms:exact_synonym: 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol
 related_synonym: 2-Methyl-3-hydroxy-4,5-dihydroxymethyl-pyridin;   2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine;   2-methyl-3-hydroxy-4,5-di(hydroxymethyl)pyridine;   2-methyl-3-hydroxy-4,5-dihydroxymethylpyridine;   2-methyl-4,5-bis(hydroxymethyl)-3-hydroxypyridine;   2-methyl-4,5-dimethylol-pyridin-3-ol;   3-hydroxy-2-picoline-4,5-dimethanol;   3-hydroxy-4,5-bis(hydroxymethyl)-2-methylpyridine;   3-hydroxy-4,5-dimethylol-alpha-picoline;   4,5-bis(hydroxymethyl)-2-methyl-pyridin-3-ol;   5-hydroxy-6-methyl-3,4-pyridinedimethanol;   Formula=C8H11NO3;   InChI=1S/C8H11NO3/c1-5-8(12)7(4-11)6(3-10)2-9-5/h2,10-12H,3-4H2,1H3;   InChIKey=LXNHXLLTXMVWPM-UHFFFAOYSA-N;   Pyridoxol;   SMILES=CC1=C(O)C(CO)=C(CO)C=N1;   piridossina;   pyridoxina;   pyridoxinum;   pyridoxolum;   vitamin B6
 alt_id: CHEBI:14981;   CHEBI:26429;   CHEBI:8671
 xref: AGR:IND607198670;   Beilstein:139854;   CAS:65-23-6;   Chemspider:1025;   DrugBank:DB00165;   Drug_Central:2836;   FooDB:FDB000574;   Gmelin:563676;   HMDB:HMDB0000239;   KEGG:C00314;   KEGG:D08454;   KNApSAcK:C00001551;   LINCS:LSM-5324
 xref_mesh: MESH:D011736
 xref: MetaCyc:PYRIDOXINE;   PDBeChem:UEG;   PMID:10687314;   PMID:10894227;   PMID:11562405;   PMID:12640345;   PMID:12768081;   PMID:13046427;   PMID:15132238;   PMID:15369738;   PMID:15756083;   PMID:16236150;   PMID:16277693;   PMID:16690736;   PMID:17044573;   PMID:22932811;   PMID:24035968;   PMID:24601602;   PMID:2580028;   PMID:27113583;   PMID:2885064;   PMID:31093449;   PMID:32105687;   PMID:33549283;   PMID:33665688;   PMID:3710434;   PMID:559690;   PMID:6624427;   PMID:6801073;   PMID:9625217;   Reaxys:139854;   Wikipedia:Pyridoxine


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pyridoxine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Pyridoxine results in increased expression of BAX mRNA CTD PMID:28716455 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Casp8 caspase 8 increases expression ISO Pyridoxine results in increased expression of CASP8 mRNA CTD PMID:28716455 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Nefl neurofilament light chain increases secretion EXP Pyridoxine results in increased secretion of NEFL protein CTD PMID:34677616 NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO
EXP		 Pyridoxine results in increased expression of PPARGC1A mRNA CTD PMID:23056435 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Shmt1 serine hydroxymethyltransferase 1 multiple interactions ISO Pyridoxine affects the expression of and affects the activity of SHMT1 protein CTD PMID:17482557 NCBI chr10:45,468,698...45,490,833
Ensembl chr10:45,468,700...45,497,820 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    role 19854
      biological role 19852
        biochemical role 19582
          cofactor 16588
            pyridoxine 5
              5'-O-beta-D-glucosylpyridoxine 0
              pyridoxine 5'-phosphate 0
              pyridoxine hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    p-block element atom 19849
                      carbon group element atom 19766
                        carbon atom 19785
                          organic molecular entity 19785
                            organic molecule 19737
                              organic cyclic compound 19526
                                organic heterocyclic compound 18870
                                  organic heteromonocyclic compound 17791
                                    pyridines 11515
                                      hydroxypyridine 90
                                        monohydroxypyridine 57
                                          pyridoxine 5
                                            5'-O-beta-D-glucosylpyridoxine 0
                                            pyridoxine 5'-phosphate 0
                                            pyridoxine hydrochloride 0
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