adenine - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	adenine	go back to main search page
Accession:	CHEBI:16708	browse the term
Definition:	The parent compound of the 6-aminopurines, composed of a purine having an amino group at C-6.
Synonyms:	exact_synonym:	9H-purin-6-amine
	related_synonym:	6-Aminopurine; A; Ade; Adenin; Formula=C5H5N5; InChI=1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10); InChIKey=GFFGJBXGBJISGV-UHFFFAOYSA-N; SMILES=Nc1ncnc2[nH]cnc12
	alt_id:	CHEBI:13733; CHEBI:22236; CHEBI:2470; CHEBI:40579
	xref:	Beilstein:608603; CAS:73-24-5; DrugBank:DB00173; Drug_Central:89; Gmelin:3903; HMDB:HMDB0000034; KEGG:C00147; KEGG:D00034; KNApSAcK:C00001490
	xref_mesh:	MESH:D000225
	xref:	MetaCyc:ADENINE; PDBeChem:ADE; PMID:11985597; PMID:12829005; PMID:12951489; PMID:15063338; PMID:15715490; PMID:17439666; PMID:8070089; Reaxys:608603; Wikipedia:Adenine

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Genes (1045)

adenine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aminocarboxymuconate semialdehyde decarboxylase

decreases activity

Adenine results in decreased activity of ACMSD protein

NCBI chr13:39,200,412...39,245,954
Ensembl chr13:39,200,314...39,245,209

G

actin alpha 2, smooth muscle

increases expression
multiple interactions

Adenine results in increased expression of ACTA2 protein
Adenine results in increased expression of ACTA2 mRNA
shenqui-wan inhibits the reaction [Adenine results in increased expression of ACTA2 protein]
Erhuang formula inhibits the reaction [Adenine results in increased expression of ACTA2 mRNA]; pirfenidone inhibits the reaction [Adenine results in increased expression of ACTA2 mRNA]

PMID:28866419 PMID:34619300 PMID:37245874

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

adhesion G protein-coupled receptor E1

increases expression

Adenine results in increased expression of ADGRE1 mRNA

NCBI chr 9:2,242,476...2,398,000
Ensembl chr 9:2,242,474...2,398,000

G

amyloid beta precursor protein

multiple interactions
decreases abundance

PF-06840003 inhibits the reaction [APP protein mutant form results in decreased abundance of Adenine]

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

aquaporin 1

multiple interactions
decreases expression

shenqui-wan inhibits the reaction [Adenine results in decreased expression of AQP1 protein]

NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690

G

aquaporin 9

increases uptake

AQP9 protein results in increased uptake of Adenine

NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395

G

BLM RecQ like helicase

decreases expression

Adenine results in decreased expression of BLM mRNA

NCBI chr 1:134,409,832...134,496,073
Ensembl chr 1:134,409,857...134,484,312

G

BTG anti-proliferation factor 1

decreases expression

Adenine results in decreased expression of BTG1 mRNA

NCBI chr 7:31,341,391...31,343,649
Ensembl chr 7:31,341,027...31,343,649

G

BTG anti-proliferation factor 2

decreases expression

Adenine results in decreased expression of BTG2 mRNA

NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628

G

BTG anti-proliferation factor 3

decreases expression

Adenine results in decreased expression of BTG3 mRNA

NCBI chr11:17,030,156...17,046,069
Ensembl chr11:17,030,160...17,046,170

G

catalase

multiple interactions

[Phosphates co-treated with Adenine] results in increased expression of CAT protein; linalool inhibits the reaction [[Phosphates co-treated with Adenine] results in increased expression of CAT protein]

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

coiled-coil domain containing 51

decreases expression

Adenine results in decreased expression of CCDC51 mRNA

NCBI chr 8:109,722,595...109,741,478
Ensembl chr 8:109,722,557...109,741,472

G

C-C motif chemokine ligand 2

increases expression

Adenine results in increased expression of CCL2 mRNA

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 5

increases expression

Adenine results in increased expression of CCL5 mRNA

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

cellular communication network factor 2

increases expression
multiple interactions

Adenine results in increased expression of CCN2 mRNA
camostat inhibits the reaction [Adenine results in increased expression of CCN2 mRNA]

NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734

G

cyclin E2

decreases expression

Adenine results in decreased expression of CCNE2 mRNA

NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632

G

CD3 epsilon subunit of T-cell receptor complex

increases expression

Adenine results in increased expression of CD3E mRNA; Adenine results in increased expression of CD3E protein

NCBI chr 8:45,303,848...45,315,005
Ensembl chr 8:45,303,852...45,315,022

G

Cd68 molecule

increases expression

Adenine results in increased expression of CD68 mRNA; Adenine results in increased expression of CD68 protein

NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697

G

cell division cycle 25A

decreases expression

Adenine results in decreased expression of CDC25A mRNA

NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701

G

cell division cycle 6

decreases expression

Adenine results in decreased expression of CDC6 mRNA

NCBI chr10:83,864,189...83,878,011
Ensembl chr10:83,864,638...83,878,011

G

cadherin 1

multiple interactions
decreases expression

shenqui-wan inhibits the reaction [Adenine results in decreased expression of CDH1 protein]
Erhuang formula inhibits the reaction [Adenine results in decreased expression of CDH1 protein]; pirfenidone inhibits the reaction [Adenine results in decreased expression of CDH1 protein]

PMID:28866419 PMID:37245874

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

cyclin-dependent kinase inhibitor 1A

decreases expression

Adenine results in decreased expression of CDKN1A mRNA

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

chromatin assembly factor 1 subunit A

decreases expression

Adenine results in decreased expression of CHAF1A mRNA

NCBI chr 9:873,953...900,701
Ensembl chr 9:874,051...900,654

G

chromatin assembly factor 1 subunit B

decreases expression

Adenine results in decreased expression of CHAF1B mRNA

NCBI chr11:33,200,894...33,221,076
Ensembl chr11:33,200,981...33,221,070

G

CLN8, transmembrane ER and ERGIC protein

decreases expression

Adenine results in decreased expression of CLN8 mRNA

NCBI chr16:74,749,662...74,759,553
Ensembl chr16:74,749,662...74,759,774

G

cytochrome c oxidase assembly factor 7

decreases expression

Adenine results in decreased expression of COA7 mRNA

NCBI chr 5:123,069,356...123,080,942
Ensembl chr 5:123,069,371...123,080,199

G

collagen type I alpha 1 chain

increases expression
multiple interactions

Adenine results in increased expression of COL1A1 mRNA
Adenine results in increased expression of COL1A1 mRNA; Adenine results in increased expression of COL1A1 protein
camostat inhibits the reaction [Adenine results in increased expression of COL1A1 mRNA]

PMID:25766432 PMID:34619300

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

collagen type I alpha 2 chain

increases expression

Adenine results in increased expression of COL1A2 mRNA

NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867

G

collagen type III alpha 1 chain

multiple interactions
increases expression

camostat inhibits the reaction [Adenine results in increased expression of COL3A1 mRNA]

PMID:25766432 PMID:34619300

NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547

G

carnitine palmitoyltransferase 2

decreases expression

Adenine results in decreased expression of CPT2 mRNA

NCBI chr 5:122,664,677...122,682,126
Ensembl chr 5:122,664,677...122,682,095

G

catenin beta 1

multiple interactions
increases expression

Erhuang formula inhibits the reaction [Adenine results in increased expression of CTNNB1 protein]; pirfenidone inhibits the reaction [Adenine results in increased expression of CTNNB1 protein]

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

C-X-C motif chemokine ligand 3

increases expression

Adenine results in increased expression of CXCL1 mRNA

NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511

G

cytochrome b-245 beta chain

increases expression
multiple interactions

Adenine results in increased expression of CYBB mRNA
camostat inhibits the reaction [Adenine results in increased expression of CYBB mRNA]

NCBI chr X:13,358,101...13,392,570
Ensembl chr X:13,359,430...13,392,586

G

DNA-damage-inducible transcript 4

decreases expression

Adenine results in decreased expression of DDIT4 mRNA

NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105

G

dual specificity phosphatase 14

decreases expression

Adenine results in decreased expression of DUSP14 mRNA

NCBI chr10:68,936,483...68,966,347
Ensembl chr10:68,935,330...68,965,329

G

E2F transcription factor 1

decreases expression

Adenine results in decreased expression of E2F1 mRNA

NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361

G

ectodermal-neural cortex 1

decreases expression

Adenine results in decreased expression of ENC1 mRNA

NCBI chr 2:28,550,670...28,562,591
Ensembl chr 2:28,550,464...28,562,713

G

ferredoxin reductase

decreases expression

Adenine results in decreased expression of FDXR mRNA

NCBI chr10:100,507,863...100,516,649
Ensembl chr10:100,507,865...100,516,658

G

fibroblast growth factor 23

increases expression

Adenine results in increased expression of FGF23 protein

NCBI chr 4:159,914,267...159,923,821
Ensembl chr 4:159,914,272...159,923,821

G

fibronectin 1

increases expression
multiple interactions

Adenine results in increased expression of FN1 mRNA
Erhuang formula inhibits the reaction [Adenine results in increased expression of FN1 protein]; pirfenidone inhibits the reaction [Adenine results in increased expression of FN1 protein]

PMID:28866419 PMID:34619300

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

forkhead box J2

decreases expression

Adenine results in decreased expression of FOXJ2 mRNA

NCBI chr 4:156,047,043...156,073,540
Ensembl chr 4:156,046,969...156,073,518

G

forkhead box O3

multiple interactions

Adenine results in increased expression of and results in increased phosphorylation of FOXO3 protein

NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561

G

frizzled class receptor 1

decreases expression

Adenine results in decreased expression of FZD1 mRNA

NCBI chr 4:29,310,303...29,314,701
Ensembl chr 4:29,310,091...29,312,643
Ensembl chr 4:29,310,091...29,312,643

G

GTP cyclohydrolase 1

decreases expression

Adenine results in decreased expression of GCH1 mRNA

NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698

G

growth differentiation factor 15

decreases expression

Adenine results in decreased expression of GDF15 mRNA

NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055

G

gastrin releasing peptide

increases expression

Adenine increases expression of Grp mRNA in the aorta

RGD

NCBI chr18:59,388,679...59,402,061
Ensembl chr18:59,388,274...59,402,061

G

GrpE-like 1, mitochondrial

decreases expression

Adenine results in decreased expression of GRPEL1 mRNA

NCBI chr14:74,292,023...74,298,243
Ensembl chr14:74,292,023...74,298,200

G

hepatitis A virus cellular receptor 1

increases expression

Adenine results in increased expression of HAVCR1 protein

NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698

G

histone deacetylase 2

decreases expression

Adenine results in decreased expression of HDAC2 protein

NCBI chr20:40,548,244...40,571,609
Ensembl chr20:40,548,250...40,571,609

G

heterogeneous nuclear ribonucleoprotein D

multiple interactions

[Adenine co-treated with Phosphorus] results in increased metabolism of HNRNPD protein; Adenine promotes the reaction [HNRNPD protein binds to PTH 3' UTR]; N-(2-chlorophenylpropyl)-1-(3-methoxyphenyl)ethylamine inhibits the reaction [[Adenine co-treated with Phosphorus] results in increased metabolism of HNRNPD protein]

PMID:16291838 PMID:18583400

NCBI chr14:9,615,375...9,638,975
Ensembl chr14:9,615,479...9,633,786

G

inhibitor of DNA binding 3

decreases expression

Adenine results in decreased expression of ID3 mRNA

NCBI chr 5:148,372,784...148,374,353
Ensembl chr 5:148,372,762...148,374,349

G

interferon gamma

multiple interactions

Adenine inhibits the reaction [deoxynivalenol inhibits the reaction [[IFNG protein co-treated with TNF protein co-treated with IL1B protein] results in increased expression of NOS2 protein]]

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

interleukin 1 beta

multiple interactions
increases expression

Adenine inhibits the reaction [deoxynivalenol inhibits the reaction [[IFNG protein co-treated with TNF protein co-treated with IL1B protein] results in increased expression of NOS2 protein]]
Adenine results in increased expression of IL1B mRNA

PMID:25766886 PMID:34619300

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

increases expression

Adenine results in increased expression of IL6 mRNA

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

integrator complex subunit 15

decreases expression

Adenine results in decreased expression of INTS15 mRNA

NCBI chr12:11,245,045...11,260,170
Ensembl chr12:11,245,842...11,260,166

G

interferon stimulated exonuclease gene 20-like 2

decreases expression

Adenine results in decreased expression of ISG20L2 mRNA

NCBI chr 2:173,396,780...173,407,102
Ensembl chr 2:173,396,780...173,406,614

G

KH-type splicing regulatory protein

multiple interactions

Adenine inhibits the reaction [KHSRP protein binds to PTH 3' UTR]

NCBI chr 9:1,862,555...1,872,403
Ensembl chr 9:1,862,899...1,872,451

G

kinesin family member 20A

decreases expression

Adenine results in decreased expression of KIF20A mRNA

NCBI chr18:26,230,294...26,238,780
Ensembl chr18:26,230,230...26,238,780

G

KLF transcription factor 2

decreases expression
multiple interactions

Adenine results in decreased expression of KLF2 protein
[Cinacalcet inhibits the reaction [Adenine results in increased expression of TRAF2 protein]] which results in decreased ubiquitination of and results in decreased degradation of KLF2 protein; Cinacalcet inhibits the reaction [Adenine results in decreased expression of KLF2 protein]; KLF2 protein inhibits the reaction [Adenine results in increased expression of SERPINA3 mRNA]; KLF2 protein inhibits the reaction [Adenine results in increased expression of SERPINA3 protein]

NCBI chr16:17,521,107...17,523,739
Ensembl chr16:17,514,552...17,523,944

G

LIM homeobox 2

decreases expression

Adenine results in decreased expression of LHX2 mRNA

NCBI chr 3:22,113,619...22,143,909
Ensembl chr 3:22,126,007...22,143,908

G

leucine rich repeat containing 47

decreases expression

Adenine results in decreased expression of LRRC47 mRNA

NCBI chr 5:164,570,539...164,580,174
Ensembl chr 5:164,570,435...164,580,174

G

minichromosome maintenance 10 replication initiation factor

decreases expression

Adenine results in decreased expression of MCM10 mRNA

NCBI chr17:73,263,788...73,288,346
Ensembl chr17:73,266,095...73,287,364

G

myelin protein zero-like 1

decreases expression

Adenine results in decreased expression of MPZL1 mRNA

NCBI chr13:77,852,467...77,889,305
Ensembl chr13:77,852,467...77,896,616

G

mitochondrial rRNA methyltransferase 2

decreases expression

Adenine results in decreased expression of MRM2 mRNA

NCBI chr12:14,309,556...14,314,759
Ensembl chr12:14,251,941...14,314,118

G

mutS homolog 6

decreases expression

Adenine results in decreased expression of MSH6 mRNA

NCBI chr 6:6,562,631...6,579,995
Ensembl chr 6:6,562,632...6,579,956

G

nitric oxide synthase 2

multiple interactions

Adenine inhibits the reaction [deoxynivalenol inhibits the reaction [[IFNG protein co-treated with TNF protein co-treated with IL1B protein] results in increased expression of NOS2 protein]]

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

NADPH oxidase 1

increases expression
multiple interactions

Adenine results in increased expression of NOX1 mRNA
camostat inhibits the reaction [Adenine results in increased expression of NOX1 mRNA]

NCBI chr X:97,279,058...97,332,291
Ensembl chr X:97,279,056...97,302,236

G

ORAI calcium release-activated calcium modulator 3

decreases expression

Adenine results in decreased expression of ORAI3 mRNA

NCBI chr 1:182,381,196...182,386,055
Ensembl chr 1:182,344,293...182,386,052

G

partner and localizer of BRCA2

decreases expression

Adenine results in decreased expression of PALB2 mRNA

NCBI chr 1:176,665,076...176,689,053
Ensembl chr 1:176,665,076...176,688,990

G

pelota mRNA surveillance and ribosome rescue factor

decreases expression

Adenine results in decreased expression of PELO mRNA

NCBI chr 2:46,797,853...46,799,621
Ensembl chr 2:46,797,853...46,799,746

G

pleckstrin homology-like domain, family A, member 3

decreases expression

Adenine results in decreased expression of PHLDA3 mRNA

NCBI chr13:47,193,250...47,196,335
Ensembl chr13:47,193,086...47,196,335

G

p53-induced death domain protein 1

decreases expression

Adenine results in decreased expression of PIDD1 mRNA

NCBI chr 1:196,536,815...196,542,808
Ensembl chr 1:196,536,834...196,542,699

G

pleckstrin homology and FYVE domain containing 1

decreases expression

Adenine results in decreased expression of PLEKHF1 mRNA

NCBI chr 1:90,908,304...90,915,862
Ensembl chr 1:90,904,742...90,915,820

G

plexin B2

decreases expression

Adenine results in decreased expression of PLXNB2 mRNA

NCBI chr 7:120,232,276...120,258,385
Ensembl chr 7:120,232,331...120,258,330

G

peroxisome proliferator-activated receptor gamma

decreases expression
multiple interactions

Adenine results in decreased expression of PPARG mRNA
pirfenidone inhibits the reaction [Adenine results in decreased expression of PPARG mRNA]

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

protein phosphatase, Mg2+/Mn2+ dependent, 1D

decreases expression

Adenine results in decreased expression of PPM1D mRNA

NCBI chr10:70,172,603...70,208,607
Ensembl chr10:70,172,603...70,208,607

G

protein kinase AMP-activated non-catalytic subunit beta 1

decreases expression

Adenine results in decreased expression of PRKAB1 mRNA

NCBI chr12:40,588,140...40,598,673
Ensembl chr12:40,588,211...40,598,661

G

PSMC3 interacting protein

decreases expression

Adenine results in decreased expression of PSMC3IP mRNA

NCBI chr10:86,024,281...86,027,928
Ensembl chr10:86,023,950...86,027,423

G

parathyroid hormone

multiple interactions
increases stability
increases expression

[Adenine co-treated with Phosphorus] results in increased expression of PTH mRNA; [Adenine co-treated with Phosphorus] results in increased expression of PTH protein; Adenine inhibits the reaction [KHSRP protein binds to PTH 3' UTR]; Adenine promotes the reaction [HNRNPD protein binds to PTH 3' UTR]; N-(2-chlorophenylpropyl)-1-(3-methoxyphenyl)ethylamine inhibits the reaction [[Adenine co-treated with Phosphorus] results in increased expression of PTH protein]
Adenine results in increased stability of PTH mRNA
Adenine results in increased expression of PTH protein

PMID:16272627 PMID:16291838 PMID:18583400

NCBI chr 1:167,508,121...167,511,530
Ensembl chr 1:167,508,598...167,511,530

G

protein tyrosine phosphatase 4A1

decreases expression

Adenine results in decreased expression of PTP4A1 mRNA

NCBI chr 9:33,214,201...33,245,046
Ensembl chr 9:33,214,208...33,221,964

G

pseudouridine synthase 3

decreases expression

Adenine results in decreased expression of PUS3 mRNA

NCBI chr 8:33,910,461...33,918,716
Ensembl chr 8:33,911,357...33,918,714

G

RAD51 paralog C

decreases expression

Adenine results in decreased expression of RAD51C mRNA

NCBI chr10:72,205,032...72,231,643
Ensembl chr10:72,205,032...72,231,248

G

RAP2B, member of RAS oncogene family

decreases expression

Adenine results in decreased expression of RAP2B mRNA

NCBI chr 2:145,599,714...145,600,265
Ensembl chr 2:145,599,116...145,603,069

G

RNA binding motif protein 34

decreases expression

Adenine results in decreased expression of RBM34 mRNA

NCBI chr19:54,936,516...54,956,810
Ensembl chr19:54,936,531...54,956,715

G

RELA proto-oncogene, NF-kB subunit

multiple interactions
increases expression

Adenine results in increased expression of and results in increased phosphorylation of RELA protein
Adenine results in increased expression of RELA mRNA
Erhuang formula inhibits the reaction [Adenine results in increased expression of RELA mRNA]; pirfenidone inhibits the reaction [Adenine results in increased expression of RELA mRNA]

PMID:28866419 PMID:34619300

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

replication factor C subunit 1

decreases expression

Adenine results in decreased expression of RFC1 mRNA

NCBI chr14:42,966,279...43,041,372
Ensembl chr14:42,966,324...43,041,370

G

regulator of G-protein signaling 16

decreases expression

Adenine results in decreased expression of RGS16 mRNA

NCBI chr13:65,887,668...65,892,862
Ensembl chr13:65,887,530...65,892,857

G

ring finger protein 113A1

decreases expression

Adenine results in decreased expression of RNF113A mRNA

NCBI chr X:116,427,941...116,429,164
Ensembl chr X:116,427,684...116,433,762

G

ring finger protein 19B

decreases expression

Adenine results in decreased expression of RNF19B mRNA

NCBI chr 5:141,406,085...141,431,376
Ensembl chr 5:141,406,118...141,431,380

G

RUNX family transcription factor 2

multiple interactions

[Phosphates co-treated with Adenine] results in increased expression of RUNX2 mRNA; linalool inhibits the reaction [[Phosphates co-treated with Adenine] results in increased expression of RUNX2 mRNA]

NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167

G

SAC3 domain containing 1

decreases expression

Adenine results in decreased expression of SAC3D1 mRNA

NCBI chr 1:203,414,184...203,416,563
Ensembl chr 1:203,414,187...203,416,604

G

syndecan 1

decreases expression

Adenine results in decreased expression of SDC1 mRNA

NCBI chr 6:31,562,799...31,585,267
Ensembl chr 6:31,562,739...31,585,264

G

succinate dehydrogenase complex assembly factor 1

decreases expression

Adenine results in decreased expression of SDHAF1 mRNA

NCBI chr 1:85,576,207...85,577,156
Ensembl chr 1:85,576,041...85,577,366
Ensembl chr 1:85,576,041...85,577,366

G

serpin family E member 1

multiple interactions
increases expression

camostat inhibits the reaction [Adenine results in increased expression of SERPINE1 mRNA]

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

G

sestrin 1

decreases expression

Adenine results in decreased expression of SESN1 mRNA

NCBI chr20:45,294,876...45,387,698
Ensembl chr20:45,294,871...45,387,697

G

serum/glucocorticoid regulated kinase 1

decreases expression

Adenine results in decreased expression of SGK1 mRNA

NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283

G

stem-loop histone mRNA binding protein

decreases expression

Adenine results in decreased expression of SLBP mRNA

NCBI chr14:77,071,441...77,081,911
Ensembl chr14:77,071,632...77,081,906

G

solute carrier family 1 member 5

decreases expression

Adenine results in decreased expression of SLC1A5 mRNA

NCBI chr 1:77,456,849...77,470,952
Ensembl chr 1:77,456,694...77,470,952

G

solute carrier family 20 member 1

multiple interactions

[Phosphates co-treated with Adenine] results in increased expression of SLC20A1 mRNA; linalool inhibits the reaction [[Phosphates co-treated with Adenine] results in increased expression of SLC20A1 mRNA]

NCBI chr 3:116,427,095...116,441,049
Ensembl chr 3:116,427,098...116,441,051

G

solute carrier family 29 member 2

multiple interactions

Adenine inhibits the reaction [SLC29A2 protein results in increased uptake of Uridine]

NCBI chr 1:202,327,641...202,335,185
Ensembl chr 1:202,327,354...202,335,171

G

sclerostin

affects response to substance

SOST affects the susceptibility to Adenine

NCBI chr10:86,912,517...86,915,561
Ensembl chr10:86,911,517...86,915,561

G

secreted phosphoprotein 1

multiple interactions
increases expression

[Phosphates co-treated with Adenine] results in increased expression of SPP1 mRNA; Erhuang formula inhibits the reaction [Adenine results in increased expression of SPP1 mRNA]; linalool inhibits the reaction [[Phosphates co-treated with Adenine] results in increased expression of SPP1 mRNA]; pirfenidone inhibits the reaction [Adenine results in increased expression of SPP1 mRNA]

PMID:28866419 PMID:30466616

NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162

G

trefoil factor 1

multiple interactions

Adenine affects the reaction [deoxynivalenol affects the expression of TFF1 mRNA]

NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597

G

trefoil factor 2

multiple interactions

Adenine affects the reaction [deoxynivalenol affects the expression of TFF2 mRNA]

NCBI chr20:9,215,750...9,219,619
Ensembl chr20:9,215,761...9,219,619

G

trefoil factor 3

multiple interactions

Adenine affects the reaction [deoxynivalenol affects the expression of TFF3 mRNA]

NCBI chr20:9,193,259...9,197,969
Ensembl chr20:9,193,262...9,198,054

G

transforming growth factor, beta 1

multiple interactions
increases expression

camostat inhibits the reaction [Adenine results in increased expression of TGFB1 mRNA]; Erhuang formula inhibits the reaction [Adenine results in increased expression of TGFB1 mRNA]; pirfenidone inhibits the reaction [Adenine results in increased expression of TGFB1 mRNA]

PMID:25766432 PMID:28866419

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

TP53 induced glycolysis regulatory phosphatase

decreases expression

Adenine results in decreased expression of TIGAR mRNA

NCBI chr 4:159,927,136...159,946,077
Ensembl chr 4:159,927,139...159,946,029

G

timeless interacting protein

decreases expression

Adenine results in decreased expression of TIPIN mRNA

NCBI chr 8:64,780,813...64,801,358
Ensembl chr 8:64,780,828...64,801,352

G

transmembrane protein 185B

decreases expression

Adenine results in decreased expression of TMEM185B mRNA

NCBI chr13:30,647,533...30,650,864
Ensembl chr13:30,647,482...30,650,858

G

tumor necrosis factor

multiple interactions
increases expression

Adenine inhibits the reaction [deoxynivalenol inhibits the reaction [[IFNG protein co-treated with TNF protein co-treated with IL1B protein] results in increased expression of NOS2 protein]]
Erhuang formula inhibits the reaction [Adenine results in increased expression of TNF mRNA]; pirfenidone inhibits the reaction [Adenine results in increased expression of TNF mRNA]

PMID:25766886 PMID:28866419 PMID:34619300

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF superfamily member 9

decreases expression

Adenine results in decreased expression of TNFSF9 mRNA

NCBI chr 9:1,944,017...1,946,351
Ensembl chr 9:1,944,017...1,946,345

G

DNA topoisomerase III alpha

decreases expression

Adenine results in decreased expression of TOP3A mRNA

NCBI chr10:45,419,219...45,457,356
Ensembl chr10:45,419,217...45,457,559

G

torsin family 1, member A

decreases expression

Adenine results in decreased expression of TOR1A mRNA

NCBI chr 3:14,250,667...14,257,704
Ensembl chr 3:14,250,676...14,257,691

G

Tnf receptor-associated factor 2

increases expression
multiple interactions

Adenine results in increased expression of TRAF2 protein
[Cinacalcet inhibits the reaction [Adenine results in increased expression of TRAF2 protein]] which results in decreased ubiquitination of and results in decreased degradation of KLF2 protein; Cinacalcet inhibits the reaction [Adenine results in increased expression of TRAF2 protein]

NCBI chr 3:8,341,950...8,366,609
Ensembl chr 3:8,341,951...8,366,538

G

TP53 regulated inhibitor of apoptosis 1

decreases expression

Adenine results in decreased expression of TRIAP1 mRNA

NCBI chr12:41,267,534...41,270,053
Ensembl chr12:41,267,549...41,270,042

G

tripartite motif-containing 26

decreases expression

Adenine results in decreased expression of TRIM26 mRNA

NCBI chr20:1,708,297...1,731,176
Ensembl chr20:1,709,788...1,731,120

G

tripartite motif-containing 32

decreases expression

Adenine results in decreased expression of TRIM32 mRNA

NCBI chr 5:79,005,139...79,016,615
Ensembl chr 5:78,999,389...79,022,018

G

tripartite motif containing 38

decreases expression

Adenine results in decreased expression of TRIM38 mRNA

NCBI chr17:41,351,857...41,365,021

G

UTP3, small subunit processome component

decreases expression

Adenine results in decreased expression of UTP3 mRNA

NCBI chr14:19,515,716...19,517,370
Ensembl chr14:19,515,669...19,517,396

G

vimentin

increases expression
multiple interactions

Adenine results in increased expression of VIM mRNA; Adenine results in increased expression of VIM protein
shenqui-wan inhibits the reaction [Adenine results in increased expression of VIM protein]

PMID:34619300 PMID:37245874

NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187

G

XPC complex subunit, DNA damage recognition and repair factor

decreases expression

Adenine results in decreased expression of XPC mRNA

NCBI chr 4:123,993,670...124,020,922
Ensembl chr 4:123,993,666...124,021,010

G

zinc finger and BTB domain containing 24

decreases expression

Adenine results in decreased expression of ZBTB24 mRNA

NCBI chr20:44,943,302...44,965,329
Ensembl chr20:44,947,297...44,963,963

G

zinc finger protein 202

decreases expression

Adenine results in decreased expression of ZNF202 mRNA

NCBI chr 8:40,542,665...40,567,397
Ensembl chr 8:40,542,701...40,563,118

G

zinc finger protein 36, C3H type-like 1

decreases expression

Adenine results in decreased expression of ZFP36L1 mRNA

NCBI chr 6:98,930,705...98,935,748
Ensembl chr 6:98,930,718...98,935,748

G

zinc finger protein 94

decreases expression

Adenine results in decreased expression of ZNF45 mRNA

NCBI chr 1:79,858,188...79,879,702
Ensembl chr 1:79,859,180...79,879,612

1H-imidazo[2,1-i]purine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase

increases metabolic processing

ALKBH2 protein results in increased metabolism of 1,N(6)-ethenoadenine

NCBI chr12:42,494,187...42,500,929
Ensembl chr12:42,496,300...42,500,914

G

N-methylpurine-DNA glycosylase

increases metabolic processing

MPG protein results in increased metabolism of 1,N(6)-ethenoadenine

PMID:10626224 PMID:32293880

NCBI chr10:15,396,246...15,402,528
Ensembl chr10:15,395,782...15,402,520

2',3'-dideoxyadenosine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 2

multiple interactions

Dideoxyadenosine inhibits the reaction [[EGF protein co-treated with 1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone] results in decreased activity of ABCC2 protein]; Dideoxyadenosine inhibits the reaction [Taurolithocholic Acid affects the localization of ABCC2 protein]; Dideoxyadenosine inhibits the reaction [Taurolithocholic Acid results in decreased activity of ABCC2 protein]

PMID:25813982 PMID:31300867

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

epidermal growth factor

multiple interactions

Dideoxyadenosine inhibits the reaction [[EGF protein co-treated with 1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone] results in decreased activity of ABCC2 protein]

NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064

3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensin I converting enzyme

affects activity

Puromycin Aminonucleoside affects the activity of ACE protein

NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131

G

aminocarboxymuconate semialdehyde decarboxylase

decreases activity

Puromycin Aminonucleoside results in decreased activity of ACMSD protein

NCBI chr13:39,200,412...39,245,954
Ensembl chr13:39,200,314...39,245,209

G

actin, beta

decreases expression

Puromycin Aminonucleoside results in decreased expression of ACTB protein

NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877

G

actin, gamma 1

decreases expression

Puromycin Aminonucleoside results in decreased expression of ACTG1 protein

NCBI chr10:105,619,738...105,622,587
Ensembl chr10:105,619,737...105,624,232
Ensembl chr 3:105,619,737...105,624,232

G

actin related protein 2

increases expression

Puromycin Aminonucleoside results in increased expression of ACTR2 mRNA; Puromycin Aminonucleoside results in increased expression of ACTR2 protein

NCBI chr14:94,296,443...94,333,735
Ensembl chr14:94,296,443...94,340,524

G

actin related protein 3

increases expression

Puromycin Aminonucleoside results in increased expression of ACTR3 protein

NCBI chr13:36,800,739...36,843,837
Ensembl chr13:36,800,093...36,844,124

G

angiotensinogen

affects expression
decreases expression
increases expression
multiple interactions

Puromycin Aminonucleoside affects the expression of AGT protein
Puromycin Aminonucleoside results in decreased expression of AGT protein
Puromycin Aminonucleoside results in increased expression of AGT mRNA
[Puromycin Aminonucleoside co-treated with Cholesterol] results in increased expression of AGT mRNA

PMID:2236972 PMID:8446257 PMID:12495295

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

angiotensin II receptor, type 2

multiple interactions
increases expression

[Puromycin Aminonucleoside co-treated with Cholesterol] results in increased expression of AGTR2 mRNA
Puromycin Aminonucleoside results in increased expression of AGTR2 mRNA

NCBI chr X:112,119,876...112,124,060
Ensembl chr X:112,120,228...112,124,057

G

alanine-glyoxylate aminotransferase 2

increases expression

Puromycin Aminonucleoside results in increased expression of AGXT2 protein

NCBI chr 2:59,336,252...59,377,664
Ensembl chr 2:59,336,283...59,377,926

G

apoptosis inducing factor, mitochondria associated 1

multiple interactions
affects localization

Dexamethasone inhibits the reaction [Puromycin Aminonucleoside affects the localization of AIFM1 protein]

NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256

G

albumin

affects transport
increases secretion
increases expression
affects localization
decreases expression

Puromycin Aminonucleoside affects the transport of ALB protein
Puromycin Aminonucleoside results in increased secretion of ALB protein
Puromycin Aminonucleoside results in increased expression of ALB mRNA; Puromycin Aminonucleoside results in increased expression of ALB protein
Puromycin Aminonucleoside affects the localization of ALB protein
Puromycin Aminonucleoside results in decreased expression of ALB protein

PMID:1453496 PMID:3301049 PMID:8413769 PMID:15798086 PMID:19264907 More...

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

aldehyde dehydrogenase 1 family, member A2

increases expression

Puromycin Aminonucleoside results in increased expression of ALDH1A2 mRNA

NCBI chr 8:71,877,850...71,957,107
Ensembl chr 8:71,877,850...71,957,107

G

angiopoietin 1

increases expression

Puromycin Aminonucleoside results in increased expression of ANGPT1 mRNA

NCBI chr 7:73,528,345...73,783,953
Ensembl chr 7:73,531,486...73,784,067

G

apurinic/apyrimidinic endodeoxyribonuclease 1

multiple interactions
increases expression

1,3-dimethylthiourea inhibits the reaction [Puromycin Aminonucleoside results in increased expression of APEX1 protein]

NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785

G

apolipoprotein A1

decreases response to substance
increases expression

APOA1 protein results in decreased susceptibility to Puromycin Aminonucleoside
Puromycin Aminonucleoside results in increased expression of APOA1 mRNA; Puromycin Aminonucleoside results in increased expression of APOA1 protein

PMID:7066357 PMID:7442475 PMID:7595070 PMID:8412754 PMID:8413767 More...

NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035

G

apolipoprotein A2

increases expression

Puromycin Aminonucleoside results in increased expression of APOA2 protein

NCBI chr13:83,644,460...83,646,358
Ensembl chr13:83,644,470...83,646,355

G

apolipoprotein A4

decreases expression
increases expression

Puromycin Aminonucleoside results in decreased expression of APOA4 protein
Puromycin Aminonucleoside results in increased expression of APOA4 mRNA; Puromycin Aminonucleoside results in increased expression of APOA4 protein

PMID:7442475 PMID:8412754

NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469

G

apolipoprotein B

increases expression

Puromycin Aminonucleoside results in increased expression of APOB protein

PMID:2725289 PMID:7442475 PMID:8506949

NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497

G

apolipoprotein E

decreases response to substance
increases expression
affects expression

APOE protein results in decreased susceptibility to Puromycin Aminonucleoside
Puromycin Aminonucleoside results in increased expression of APOE protein
Puromycin Aminonucleoside affects the expression of APOE mRNA

PMID:7442475 PMID:8413767 PMID:12472773

NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932

G

aquaporin 2

decreases expression

Puromycin Aminonucleoside results in decreased expression of AQP2 protein

NCBI chr 7:130,711,433...130,716,468
Ensembl chr 7:130,711,413...130,716,468

G

aquaporin 3 (Gill blood group)

decreases expression

Puromycin Aminonucleoside results in decreased expression of AQP3 protein

NCBI chr 5:56,239,200...56,244,718
Ensembl chr 5:56,239,201...56,244,720

G

activity-regulated cytoskeleton-associated protein

increases expression

Puromycin Aminonucleoside results in increased expression of ARC mRNA

NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378

G

ATPase Na+/K+ transporting subunit alpha 1

decreases expression
increases expression

Puromycin Aminonucleoside results in decreased expression of ATP1A1 protein
Puromycin Aminonucleoside results in increased expression of ATP1A1 mRNA

PMID:11675400 PMID:15075188

NCBI chr 2:189,020,722...189,048,826
Ensembl chr 2:189,020,722...189,048,837

G

ATPase Na+/K+ transporting subunit beta 1

increases expression

Puromycin Aminonucleoside results in increased expression of ATP1B1 mRNA

NCBI chr13:76,786,580...76,807,096
Ensembl chr13:76,786,578...76,807,459

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2

decreases expression

Puromycin Aminonucleoside results in decreased expression of ATP2A2 mRNA; Puromycin Aminonucleoside results in decreased expression of ATP2A2 protein

NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101

G

arginine vasopressin

increases expression

Puromycin Aminonucleoside results in increased expression of AVP protein

NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425

G

BCL2 associated X, apoptosis regulator

increases expression
multiple interactions

Puromycin Aminonucleoside results in increased expression of BAX protein
Dinoprostone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of BAX protein]
Dexamethasone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of BAX protein]

PMID:15113391 PMID:15987750 PMID:16152783 PMID:16396944

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

branched chain amino acid transaminase 2

decreases activity
decreases expression

Puromycin Aminonucleoside results in decreased activity of BCAT2 protein
Puromycin Aminonucleoside results in decreased expression of BCAT2 mRNA

NCBI chr 1:96,040,407...96,060,008
Ensembl chr 1:96,042,625...96,060,007

G

butyrylcholinesterase

increases activity

Puromycin Aminonucleoside results in increased activity of BCHE protein

NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148

G

BCL2, apoptosis regulator

multiple interactions
increases expression

[Puromycin Aminonucleoside co-treated with Melatonin] results in increased expression of BCL2 protein
Puromycin Aminonucleoside results in increased expression of BCL2 protein

PMID:14993511 PMID:15113391 PMID:16152783

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

multiple interactions
decreases expression

[Puromycin Aminonucleoside co-treated with pifithrin] results in increased expression of BCL2L1 protein; Dexamethasone inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of BCL2L1 protein]
Dinoprostone affects the reaction [Puromycin Aminonucleoside results in decreased expression of BCL2L1 protein]

PMID:15987750 PMID:16396944

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479

G

bone gamma-carboxyglutamate protein

increases expression

Puromycin Aminonucleoside results in increased expression of BGLAP protein

NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495

G

baculoviral IAP repeat-containing 5

increases expression

Puromycin Aminonucleoside results in increased expression of BIRC5 mRNA; Puromycin Aminonucleoside results in increased expression of BIRC5 protein

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

G

bone morphogenetic protein 7

multiple interactions
decreases expression

1,25-dihydroxyvitamin D inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of BMP7 mRNA]; 1,25-dihydroxyvitamin D inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of BMP7 protein]
Puromycin Aminonucleoside results in decreased expression of BMP7 mRNA; Puromycin Aminonucleoside results in decreased expression of BMP7 protein

NCBI chr 3:161,639,915...161,716,938
Ensembl chr 3:161,516,462...161,716,788

G

bone morphogenetic protein receptor type 2

multiple interactions
increases expression

Drugs, Chinese Herbal inhibits the reaction [Puromycin Aminonucleoside results in increased expression of BMPR2 mRNA]; Fosinopril inhibits the reaction [Puromycin Aminonucleoside results in increased expression of BMPR2 mRNA]

NCBI chr 9:61,192,718...61,307,280
Ensembl chr 9:61,190,566...61,301,809

G

complement C3

multiple interactions
increases expression
decreases expression

cobra venom factor inhibits the reaction [Puromycin Aminonucleoside results in increased expression of C3 protein]; mizoribine inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of C3 protein]

PMID:8919236 PMID:9250166

NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429

G

complement C5

multiple interactions

CR1 inhibits the reaction [Puromycin Aminonucleoside results in increased expression of [C5 protein alternative form binds to C9 protein]]
cobra venom factor inhibits the reaction [Puromycin Aminonucleoside results in increased expression of [C5 protein alternative form binds to C9 protein]]; Puromycin Aminonucleoside results in increased expression of [C5 protein alternative form binds to C9 protein]

NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994

G

complement C9

multiple interactions

CR1 inhibits the reaction [Puromycin Aminonucleoside results in increased expression of [C5 protein alternative form binds to C9 protein]]
cobra venom factor inhibits the reaction [Puromycin Aminonucleoside results in increased expression of [C5 protein alternative form binds to C9 protein]]; Puromycin Aminonucleoside results in increased expression of [C5 protein alternative form binds to C9 protein]

NCBI chr 2:55,573,094...55,621,345
Ensembl chr 2:55,572,992...55,621,338

G

caspase 3

multiple interactions
increases activity

Colforsin inhibits the reaction [Puromycin Aminonucleoside results in increased activity of CASP3 protein]; Dinoprostone inhibits the reaction [Puromycin Aminonucleoside results in increased activity of CASP3 protein]; L-161982 promotes the reaction [Puromycin Aminonucleoside results in increased activity of CASP3 protein]

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

catalase

increases activity
decreases activity
decreases expression
affects activity
multiple interactions

Puromycin Aminonucleoside results in increased activity of CAT protein
Puromycin Aminonucleoside results in decreased activity of CAT protein
Puromycin Aminonucleoside results in decreased expression of CAT mRNA
Puromycin Aminonucleoside affects the activity of CAT protein
[Methylprednisolone co-treated with Puromycin Aminonucleoside] results in increased activity of CAT protein; Cyclosporine inhibits the reaction [Puromycin Aminonucleoside results in decreased activity of CAT protein]; Puromycin Aminonucleoside results in decreased expression of and results in decreased activity of CAT protein; sho-saiko-to-kyo-shokyo-ka-oren-bukuryo inhibits the reaction [Puromycin Aminonucleoside results in decreased activity of CAT protein]

PMID:1744988 PMID:1942778 PMID:6246912 PMID:8289993 PMID:9355075 More...

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

C-C motif chemokine ligand 1

affects expression

Puromycin Aminonucleoside affects the expression of CCL1 mRNA

NCBI chr10:67,128,331...67,131,109
Ensembl chr10:67,128,331...67,131,159

G

C-C motif chemokine ligand 2

affects expression
multiple interactions
increases expression

Puromycin Aminonucleoside affects the expression of CCL2 mRNA
fluvastatin inhibits the reaction [Puromycin Aminonucleoside results in increased expression of CCL2 mRNA]; Tretinoin inhibits the reaction [Puromycin Aminonucleoside results in increased expression of CCL2 protein]
Puromycin Aminonucleoside results in increased expression of CCL2 mRNA; Puromycin Aminonucleoside results in increased expression of CCL2 protein

PMID:10867541 PMID:12813006 PMID:16452496

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 3

affects expression

Puromycin Aminonucleoside affects the expression of CCL3 mRNA

NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938

G

C-C motif chemokine ligand 7

affects expression

Puromycin Aminonucleoside affects the expression of CCL7 mRNA

NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303

G

CD2-associated protein

multiple interactions
decreases expression

celecoxib inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of CD2AP mRNA]

NCBI chr 9:18,086,744...18,182,744
Ensembl chr 9:18,086,984...18,182,199

G

CD36 molecule

multiple interactions
increases expression

Puromycin Aminonucleoside results in increased expression of and results in increased glycosylation of CD36 protein
Puromycin Aminonucleoside results in increased expression of CD36 mRNA

NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903

G

CD44 molecule

increases expression

Puromycin Aminonucleoside results in increased expression of CD44 protein

NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620

G

cyclin-dependent kinase inhibitor 1A

multiple interactions
increases expression

1,3-dimethylthiourea inhibits the reaction [Puromycin Aminonucleoside results in increased expression of CDKN1A protein]

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

carbohydrate sulfotransferase 11

decreases expression

Puromycin Aminonucleoside results in decreased expression of CHST11 mRNA

NCBI chr 7:20,524,535...20,743,008
Ensembl chr 7:20,528,100...20,743,111

G

chondroitin sulfate synthase 1

decreases expression

Puromycin Aminonucleoside results in decreased expression of CHSY1 mRNA

NCBI chr 1:119,689,626...119,750,711
Ensembl chr 1:119,686,350...119,750,601

G

claudin 6

affects localization

Puromycin Aminonucleoside affects the localization of CLDN6 protein

NCBI chr10:12,710,302...12,713,987
Ensembl chr10:12,709,960...12,715,973

G

chloride intracellular channel 5

decreases expression

Puromycin Aminonucleoside results in decreased expression of CLIC5 protein

NCBI chr 9:16,710,980...16,813,502
Ensembl chr 9:16,710,980...16,813,427

G

collagen type I alpha 1 chain

multiple interactions
increases expression

4-(4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridin-2-yl)-N-(tetrahydro-2H-pyran-4-yl)benzamide inhibits the reaction [Puromycin Aminonucleoside results in increased expression of COL1A1 mRNA]

PMID:9527400 PMID:16570917

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

collagen type III alpha 1 chain

increases expression

Puromycin Aminonucleoside results in increased expression of COL3A1 mRNA

NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547

G

collagen type IV alpha 1 chain

multiple interactions
increases expression

Enalapril inhibits the reaction [Puromycin Aminonucleoside results in increased expression of COL4A1 mRNA]; FR 139317 inhibits the reaction [Puromycin Aminonucleoside results in increased expression of COL4A1 mRNA]; Methylprednisolone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of COL4A1 mRNA]

PMID:1762292 PMID:9175058

NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412

G

corin, serine peptidase

decreases expression

Puromycin Aminonucleoside results in decreased expression of CORIN mRNA; Puromycin Aminonucleoside results in decreased expression of CORIN protein

NCBI chr14:35,680,601...35,910,703
Ensembl chr14:35,681,304...35,909,503

G

catenin beta 1

decreases expression

Puromycin Aminonucleoside results in decreased expression of CTNNB1 protein

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

cathepsin B

decreases activity

Puromycin Aminonucleoside results in decreased activity of CTSB protein

NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500

G

cathepsin D

increases activity

Puromycin Aminonucleoside results in increased activity of CTSD protein

NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488

G

cathepsin H

decreases activity

Puromycin Aminonucleoside results in decreased activity of CTSH protein

NCBI chr 8:90,608,941...90,627,824
Ensembl chr 8:90,608,941...90,627,824

G

cathepsin L

decreases response to substance
multiple interactions
decreases activity
affects expression

CTSL gene mutant form results in decreased susceptibility to Puromycin Aminonucleoside
Puromycin Aminonucleoside results in increased activity of and results in increased expression of CTSL protein
Puromycin Aminonucleoside results in decreased activity of CTSL protein
Puromycin Aminonucleoside affects the expression of CTSL mRNA; Puromycin Aminonucleoside affects the expression of CTSL protein

PMID:10394110 PMID:15197181

NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548

G

cytochrome P450, family 11, subfamily a, polypeptide 1

multiple interactions
decreases expression

[FSHB protein co-treated with CGB3 protein] inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of CYP11A1 mRNA]; CGB3 protein inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of CYP11A1 mRNA]; FSHB protein inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of CYP11A1 mRNA]

NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338

G

cytochrome P450, family 24, subfamily a, polypeptide 1

increases expression

Puromycin Aminonucleoside results in increased expression of CYP24A1 mRNA

NCBI chr 3:159,275,947...159,290,383
Ensembl chr 3:159,275,947...159,290,383

G

cytochrome P450, family 27, subfamily b, polypeptide 1

decreases expression

Puromycin Aminonucleoside results in decreased expression of CYP27B1 mRNA

NCBI chr 7:62,869,340...62,876,242
Ensembl chr 7:62,871,297...62,876,241

G

cytochrome P450, family 2, subfamily b, polypeptide 1

decreases expression

Puromycin Aminonucleoside results in decreased expression of CYP2B1 protein

NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052

G

dopa decarboxylase

decreases activity

Puromycin Aminonucleoside results in decreased activity of DDC protein

NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208

G

dendrin

decreases expression

Puromycin Aminonucleoside results in decreased expression of DDN protein

NCBI chr 7:129,953,317...129,957,299
Ensembl chr 7:129,953,318...129,957,341

G

desmin

increases expression
multiple interactions

Puromycin Aminonucleoside results in increased expression of DES protein
triptolide inhibits the reaction [Puromycin Aminonucleoside results in increased expression of DES protein]

PMID:2183627 PMID:18509322

NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699

G

dynamin 3

increases expression

Puromycin Aminonucleoside results in increased expression of DNM3 mRNA

NCBI chr13:74,359,043...74,838,135
Ensembl chr13:74,359,213...74,838,108

G

endothelin converting enzyme 1

increases expression

Puromycin Aminonucleoside results in increased expression of ECE1 mRNA; Puromycin Aminonucleoside results in increased expression of ECE1 protein

NCBI chr 5:150,077,679...150,179,375
Ensembl chr 5:150,077,644...150,179,371

G

enoyl-CoA hydratase, short chain 1

decreases expression

Puromycin Aminonucleoside results in decreased expression of ECHS1 protein

NCBI chr 1:194,895,036...194,903,863
Ensembl chr 1:194,895,036...194,903,884

G

endothelin 1

multiple interactions
increases expression

Enalapril inhibits the reaction [Puromycin Aminonucleoside results in increased expression of EDN1 mRNA]; FR 139317 inhibits the reaction [Puromycin Aminonucleoside results in increased expression of EDN1 mRNA]; Methylprednisolone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of EDN1 mRNA]; Puromycin Aminonucleoside inhibits the reaction [EDN1 protein results in increased abundance of Cyclic GMP]

PMID:7756592 PMID:9175058 PMID:12972712

NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885

G

endothelin 3

multiple interactions

Puromycin Aminonucleoside promotes the reaction [EDN3 protein results in increased abundance of Cyclic GMP]

NCBI chr 3:163,562,307...163,586,636
Ensembl chr 3:163,562,520...163,585,093

G

endothelin receptor type A

increases expression

Puromycin Aminonucleoside results in increased expression of EDNRA mRNA

NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049

G

endothelin receptor type B

multiple interactions
increases expression

Methylprednisolone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of EDNRB mRNA]

NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115

G

electron transfer flavoprotein subunit alpha

decreases expression

Puromycin Aminonucleoside results in decreased expression of ETFA protein

NCBI chr 8:55,835,115...55,891,890
Ensembl chr 8:55,835,134...55,891,969

G

electron transfer flavoprotein subunit beta

decreases expression

Puromycin Aminonucleoside results in decreased expression of ETFB protein

NCBI chr 1:93,851,908...93,866,072
Ensembl chr 1:93,851,858...93,866,068

G

ezrin

decreases expression

Puromycin Aminonucleoside results in decreased expression of EZR protein

NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505

G

Fas cell surface death receptor

multiple interactions
increases expression

Melatonin inhibits the reaction [Puromycin Aminonucleoside results in increased expression of FAS protein]

PMID:14993511 PMID:16152783

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

Fas ligand

increases expression
multiple interactions

Puromycin Aminonucleoside results in increased expression of FASL protein
Melatonin inhibits the reaction [Puromycin Aminonucleoside results in increased expression of FASLG protein]

PMID:14993511 PMID:16152783

NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215

G

FAT atypical cadherin 1

increases expression

Puromycin Aminonucleoside results in increased expression of FAT1 mRNA; Puromycin Aminonucleoside results in increased expression of FAT1 protein

NCBI chr16:47,177,253...47,296,261
Ensembl chr16:47,177,248...47,296,107

G

Fms related receptor tyrosine kinase 1

increases expression
affects expression

Puromycin Aminonucleoside results in increased expression of FLT1 protein
Puromycin Aminonucleoside affects the expression of FLT1 mRNA

PMID:11744811 PMID:14752241

NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626

G

fibronectin 1

increases expression
multiple interactions

Puromycin Aminonucleoside results in increased expression of FN1 mRNA; Puromycin Aminonucleoside results in increased expression of FN1 protein
Tretinoin inhibits the reaction [Puromycin Aminonucleoside results in increased expression of FN1 protein]

PMID:9527400 PMID:12813006

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

follicle stimulating hormone subunit beta

multiple interactions
decreases expression

[FSHB protein co-treated with CGB3 protein] inhibits the reaction [Puromycin Aminonucleoside results in decreased abundance of Estradiol]; [FSHB protein co-treated with CGB3 protein] inhibits the reaction [Puromycin Aminonucleoside results in decreased abundance of Progesterone]; [FSHB protein co-treated with CGB3 protein] inhibits the reaction [Puromycin Aminonucleoside results in decreased abundance of Testosterone]; [FSHB protein co-treated with CGB3 protein] inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of CYP11A1 mRNA]; [FSHB protein co-treated with CGB3 protein] inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of STAR mRNA]; FSHB protein inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of CYP11A1 mRNA]; Puromycin Aminonucleoside inhibits the reaction [GNRH1 protein results in increased secretion of FSHB protein]
Puromycin Aminonucleoside results in decreased expression of FSHB protein

PMID:12269381 PMID:16574160

NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370

G

G protein subunit alpha q

increases response to substance

GNAQ protein results in increased susceptibility to Puromycin Aminonucleoside

NCBI chr 1:213,425,631...213,671,947
Ensembl chr 1:213,424,465...213,667,672

G

gonadotropin releasing hormone 1

multiple interactions

Puromycin Aminonucleoside inhibits the reaction [GNRH1 protein results in increased secretion of FSHB protein]; Puromycin Aminonucleoside inhibits the reaction [GNRH1 protein results in increased secretion of LHB protein]

NCBI chr15:41,972,482...41,976,690
Ensembl chr15:41,972,905...41,973,581
Ensembl chr15:41,972,905...41,973,581

G

glutathione peroxidase 1

multiple interactions
increases expression

[Methylprednisolone co-treated with Puromycin Aminonucleoside] results in increased activity of GPX1 protein
Puromycin Aminonucleoside results in increased expression of GPX1 mRNA

PMID:1942778 PMID:20685819

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

glutathione peroxidase 3

decreases expression

Puromycin Aminonucleoside results in decreased expression of GPX3 mRNA

NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035

G

glycogen synthase kinase 3 beta

multiple interactions
increases phosphorylation

mizoribine inhibits the reaction [Puromycin Aminonucleoside results in increased phosphorylation of GSK3B protein]

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

glutathione S-transferase pi 1

decreases expression

Puromycin Aminonucleoside results in decreased expression of GSTP1 protein

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

guanylate cyclase activator 2B

increases expression
affects expression

Puromycin Aminonucleoside results in increased expression of GUCA2B protein
Puromycin Aminonucleoside affects the expression of GUCA2B mRNA

NCBI chr 5:133,246,891...133,248,941
Ensembl chr 5:133,246,909...133,248,966

G

hydroxyacyl-CoA dehydrogenase

decreases expression

Puromycin Aminonucleoside results in decreased expression of HADH protein

NCBI chr 2:219,787,935...219,830,335
Ensembl chr 2:219,787,927...219,830,353

G

3-hydroxy-3-methylglutaryl-CoA reductase

increases activity

Puromycin Aminonucleoside results in increased activity of HMGCR protein

NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703

G

heme oxygenase 1

multiple interactions
increases expression

[piperine co-treated with Cimetidine co-treated with Pyruvates] inhibits the reaction [Puromycin Aminonucleoside results in increased expression of HMOX1 protein]
Puromycin Aminonucleoside results in increased expression of HMOX1 mRNA; Puromycin Aminonucleoside results in increased expression of HMOX1 protein

PMID:12806184 PMID:20685819

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

heparanase

increases expression

Puromycin Aminonucleoside results in increased expression of HPSE mRNA; Puromycin Aminonucleoside results in increased expression of HPSE protein

NCBI chr14:8,896,593...8,937,011
Ensembl chr14:8,896,593...8,937,010

G

heparan sulfate-glucosamine 3-sulfotransferase 1

decreases expression

Puromycin Aminonucleoside results in decreased expression of HS3ST1 mRNA

NCBI chr14:71,185,826...71,223,263
Ensembl chr14:71,185,682...71,223,248

G

heparan sulfate 6-O-sulfotransferase 1

decreases expression

Puromycin Aminonucleoside results in decreased expression of HS6ST1 mRNA

NCBI chr 9:38,283,502...38,322,684
Ensembl chr 9:38,282,395...38,322,683

G

hydroxysteroid 11-beta dehydrogenase 2

decreases activity

Puromycin Aminonucleoside results in decreased activity of HSD11B2 protein

NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899

G

heat shock protein family A (Hsp70) member 5

decreases expression

Puromycin Aminonucleoside results in decreased expression of HSPA5 protein

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

heat shock protein family A (Hsp70) member 8

affects localization

Puromycin Aminonucleoside affects the localization of HSPA8 protein

NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259

G

heat shock protein family D (Hsp60) member 1

decreases expression

Puromycin Aminonucleoside results in decreased expression of HSPD1 protein

NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662

G

intercellular adhesion molecule 1

increases expression

Puromycin Aminonucleoside results in increased expression of ICAM1 protein

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

interleukin 1 beta

increases expression

Puromycin Aminonucleoside results in increased expression of IL1B mRNA

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

integrin-linked kinase

multiple interactions
increases activity

mizoribine inhibits the reaction [Puromycin Aminonucleoside results in increased activity of ILK protein]

NCBI chr 1:160,088,839...160,095,140
Ensembl chr 1:160,088,897...160,095,140

G

integrin subunit alpha 3

decreases expression
affects expression

Puromycin Aminonucleoside results in decreased expression of ITGA3 mRNA; Puromycin Aminonucleoside results in decreased expression of ITGA3 protein
Puromycin Aminonucleoside affects the expression of ITGA3 protein

PMID:9249603 PMID:10845833 PMID:11274237 PMID:15197181

NCBI chr10:79,990,160...80,022,206
Ensembl chr10:79,990,161...80,022,118

G

integrin subunit beta 1

decreases expression
increases expression

Puromycin Aminonucleoside results in decreased expression of ITGB1 mRNA; Puromycin Aminonucleoside results in decreased expression of ITGB1 protein
Puromycin Aminonucleoside results in increased expression of ITGB1 protein

PMID:11274237 PMID:12065681 PMID:14559718

NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195

G

kinase insert domain receptor

affects expression
increases expression
decreases expression

Puromycin Aminonucleoside affects the expression of KDR mRNA
Puromycin Aminonucleoside results in increased expression of KDR mRNA; Puromycin Aminonucleoside results in increased expression of KDR protein
Puromycin Aminonucleoside results in decreased expression of KDR mRNA

PMID:11744811 PMID:14752241 PMID:17667850

NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018

G

kirre like nephrin family adhesion molecule 1

multiple interactions
decreases expression

Y 27632 inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of KIRREL1 mRNA]

NCBI chr 2:172,521,644...172,615,057
Ensembl chr 2:172,525,245...172,615,299

G

keratin 7

decreases expression

Puromycin Aminonucleoside results in decreased expression of KRT7 mRNA; Puromycin Aminonucleoside results in decreased expression of KRT7 protein

NCBI chr 7:132,528,881...132,545,052
Ensembl chr 7:132,528,895...132,545,052

G

laminin subunit beta 1

multiple interactions
increases expression

Enalapril inhibits the reaction [Puromycin Aminonucleoside results in increased expression of LAMB1 mRNA]; FR 139317 inhibits the reaction [Puromycin Aminonucleoside results in increased expression of LAMB1 mRNA]; Methylprednisolone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of LAMB1 mRNA]

PMID:1762292 PMID:9175058

NCBI chr 6:47,835,492...47,902,585
Ensembl chr 6:47,835,525...47,902,585

G

laminin subunit beta 2

multiple interactions
increases expression

Enalapril inhibits the reaction [Puromycin Aminonucleoside results in increased expression of LAMB2 mRNA]; FR 139317 inhibits the reaction [Puromycin Aminonucleoside results in increased expression of LAMB2 mRNA]; Methylprednisolone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of LAMB2 mRNA]

PMID:1762292 PMID:9175058

NCBI chr 8:109,178,367...109,190,552
Ensembl chr 8:109,178,409...109,190,549

G

lipocalin 2

increases secretion

Puromycin Aminonucleoside results in increased secretion of LCN2 protein

NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095

G

galectin 1

decreases expression

Puromycin Aminonucleoside results in decreased expression of LGALS1 protein

NCBI chr 7:110,485,239...110,488,345
Ensembl chr 7:110,481,392...110,488,345

G

luteinizing hormone subunit beta

multiple interactions
decreases expression

[FSHB protein co-treated with CGB3 protein] inhibits the reaction [Puromycin Aminonucleoside results in decreased abundance of Estradiol]; [FSHB protein co-treated with CGB3 protein] inhibits the reaction [Puromycin Aminonucleoside results in decreased abundance of Progesterone]; [FSHB protein co-treated with CGB3 protein] inhibits the reaction [Puromycin Aminonucleoside results in decreased abundance of Testosterone]; [FSHB protein co-treated with CGB3 protein] inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of CYP11A1 mRNA]; [FSHB protein co-treated with CGB3 protein] inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of STAR mRNA]; CGB3 protein inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of CYP11A1 mRNA]; Puromycin Aminonucleoside inhibits the reaction [GNRH1 protein results in increased secretion of LHB protein]
Puromycin Aminonucleoside results in decreased expression of LHB protein

PMID:12269381 PMID:16574160

NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972

G

mitogen activated protein kinase 1

multiple interactions

Puromycin Aminonucleoside results in increased expression of and results in increased phosphorylation of MAPK1 protein

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

Puromycin Aminonucleoside results in increased expression of and results in increased phosphorylation of MAPK3 protein

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

multiple interactions

Puromycin Aminonucleoside binds to and results in increased activity of MAPK8 protein

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

midkine

multiple interactions
decreases expression

Tretinoin inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of MDK mRNA]

NCBI chr 3:77,901,134...77,903,997
Ensembl chr 3:77,901,158...77,903,130

G

membrane metallo-endopeptidase

decreases expression

Puromycin Aminonucleoside results in decreased expression of MME protein

NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792

G

matrix metallopeptidase 2

multiple interactions
increases expression

FR 139317 inhibits the reaction [Puromycin Aminonucleoside results in increased expression of MMP2 mRNA]

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

moesin

increases expression

Puromycin Aminonucleoside results in increased expression of MSN protein

NCBI chr X:60,996,043...61,064,011
Ensembl chr X:60,995,951...61,065,628

G

mitochondrially encoded cytochrome c oxidase I

decreases expression

Puromycin Aminonucleoside results in decreased expression of COX1 protein

NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867

G

myosin heavy chain 10

increases expression
affects expression

Puromycin Aminonucleoside results in increased expression of MYH10 protein
Puromycin Aminonucleoside affects the expression of MYH10 mRNA; Puromycin Aminonucleoside affects the expression of MYH10 protein

PMID:7671567 PMID:8918620

NCBI chr10:53,393,901...53,525,174
Ensembl chr10:53,394,389...53,525,165

G

myosin heavy chain 6

affects expression

Puromycin Aminonucleoside affects the expression of MYH6 mRNA

NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720

G

napsin A aspartic peptidase

increases expression

Puromycin Aminonucleoside results in increased expression of NAPSA mRNA; Puromycin Aminonucleoside results in increased expression of NAPSA protein

NCBI chr 1:95,064,726...95,077,101
Ensembl chr 1:95,064,900...95,077,094

G

N-deacetylase and N-sulfotransferase 1

decreases expression
affects expression

Puromycin Aminonucleoside results in decreased expression of NDST1 mRNA
Puromycin Aminonucleoside affects the expression of NDST1 mRNA

NCBI chr18:54,136,887...54,199,545
Ensembl chr18:54,140,779...54,178,191

G

nebulette

decreases expression

Puromycin Aminonucleoside results in decreased expression of NEBL mRNA

NCBI chr17:80,113,891...80,466,331
Ensembl chr17:80,118,543...80,466,210

G

NEDD4 like E3 ubiquitin protein ligase

decreases expression

Puromycin Aminonucleoside results in decreased expression of NEDD4L protein

NCBI chr18:58,393,759...58,726,709
Ensembl chr18:58,393,509...58,723,137

G

nitric oxide synthase 1

multiple interactions
increases expression

Puromycin Aminonucleoside results in decreased expression of and results in decreased activity of NOS1 protein
Puromycin Aminonucleoside results in increased expression of NOS1 mRNA

NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945

G

nitric oxide synthase 2

increases expression

Puromycin Aminonucleoside results in increased expression of NOS2 mRNA

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

nitric oxide synthase 3

increases expression
multiple interactions

Puromycin Aminonucleoside results in increased expression of NOS3 mRNA
Puromycin Aminonucleoside results in decreased expression of and results in decreased activity of NOS3 protein

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

G

NPHS2 stomatin family member, podocin

decreases expression
multiple interactions
affects expression

Puromycin Aminonucleoside results in decreased expression of NPHS2 protein
triptolide inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of NPHS2 protein]
Puromycin Aminonucleoside affects the expression of NPHS2 mRNA; Puromycin Aminonucleoside affects the expression of NPHS2 protein

PMID:12065681 PMID:15363039 PMID:18509322

NCBI chr13:68,448,720...68,461,312
Ensembl chr13:68,448,926...68,461,313

G

natriuretic peptide A

affects metabolic processing
increases response to substance
increases expression
multiple interactions
affects expression

Puromycin Aminonucleoside affects the metabolism of NPPA protein
Puromycin Aminonucleoside results in increased susceptibility to NPPA protein
Puromycin Aminonucleoside results in increased expression of NPPA mRNA; Puromycin Aminonucleoside results in increased expression of NPPA protein
Puromycin Aminonucleoside inhibits the reaction [NPPA protein results in increased abundance of Cyclic GMP]
Puromycin Aminonucleoside affects the expression of NPPA protein

PMID:2526952 PMID:12972712 PMID:15590761 PMID:19885019 PMID:20613715

NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351

G

natriuretic peptide B

affects expression

Puromycin Aminonucleoside affects the expression of NPPB mRNA

NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168

G

natriuretic peptide receptor 1

decreases expression

Puromycin Aminonucleoside results in decreased expression of NPR1 mRNA

NCBI chr 2:175,934,181...175,950,118
Ensembl chr 2:175,934,181...175,949,505

G

natriuretic peptide receptor 3

decreases expression

Puromycin Aminonucleoside results in decreased expression of NPR3 mRNA

NCBI chr 2:60,865,483...60,933,432
Ensembl chr 2:60,870,594...60,932,955

G

nuclear respiratory factor 1

affects expression

Puromycin Aminonucleoside affects the expression of NRF1 mRNA

NCBI chr 4:58,664,932...58,772,328
Ensembl chr 4:58,664,957...58,825,328

G

optineurin

increases expression

Puromycin Aminonucleoside results in increased expression of OPTN protein

NCBI chr17:73,209,572...73,260,251
Ensembl chr17:73,209,575...73,260,251

G

podoplanin

decreases expression

Puromycin Aminonucleoside results in decreased expression of PDPN mRNA; Puromycin Aminonucleoside results in decreased expression of PDPN protein

PMID:9327748 PMID:12032185

NCBI chr 5:155,601,691...155,635,656
Ensembl chr 5:155,601,691...155,635,656

G

pleckstrin homology, MyTH4 and FERM domain containing H2

decreases expression

Puromycin Aminonucleoside results in decreased expression of PLEKHH2 protein

NCBI chr 6:10,032,837...10,132,081
Ensembl chr 6:10,032,660...10,140,794

G

phospholamban

increases expression

Puromycin Aminonucleoside results in increased expression of PLN mRNA

NCBI chr20:32,629,537...32,639,559

G

podocalyxin-like

increases expression
affects metabolic processing

Puromycin Aminonucleoside results in increased expression of PODXL mRNA; Puromycin Aminonucleoside results in increased expression of PODXL protein
Puromycin Aminonucleoside affects the metabolism of PODXL protein

PMID:8780404 PMID:11274237

NCBI chr 4:60,135,124...60,181,829
Ensembl chr 4:60,135,109...60,181,899

G

DNA polymerase beta

increases expression
multiple interactions

Puromycin Aminonucleoside results in increased expression of POLB protein
1,3-dimethylthiourea inhibits the reaction [Puromycin Aminonucleoside results in increased expression of POLB protein]

NCBI chr16:69,379,438...69,402,710
Ensembl chr16:69,379,400...69,404,812

G

peroxisome proliferator-activated receptor gamma

multiple interactions
increases expression

pioglitazone affects the reaction [Puromycin Aminonucleoside results in increased expression of PPARG protein]

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

protein phosphatase 1, regulatory subunit 12A

increases phosphorylation
increases expression
multiple interactions

Puromycin Aminonucleoside results in increased phosphorylation of PPP1R12A protein
Puromycin Aminonucleoside results in increased expression of PPP1R12A protein modified form
Y 27632 inhibits the reaction [Puromycin Aminonucleoside results in increased phosphorylation of PPP1R12A protein]
fluvastatin inhibits the reaction [Puromycin Aminonucleoside results in increased expression of PPP1R12A protein modified form]

PMID:16452496 PMID:18367845

NCBI chr 7:43,482,808...43,593,689
Ensembl chr 7:43,482,803...43,593,425

G

peroxiredoxin 3

decreases expression

Puromycin Aminonucleoside results in decreased expression of PRDX3 protein

NCBI chr 1:260,001,642...260,014,064
Ensembl chr 1:260,001,637...260,014,111

G

prostaglandin-endoperoxide synthase 2

increases expression
affects response to substance
multiple interactions

Puromycin Aminonucleoside results in increased expression of PTGS2 mRNA; Puromycin Aminonucleoside results in increased expression of PTGS2 protein
PTGS2 protein affects the susceptibility to Puromycin Aminonucleoside
celecoxib inhibits the reaction [Puromycin Aminonucleoside results in increased expression of PTGS2 mRNA]

PMID:16396944 PMID:17890881 PMID:19194550

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

parathyroid hormone

increases expression

Puromycin Aminonucleoside results in increased expression of PTH protein

NCBI chr 1:167,508,121...167,511,530
Ensembl chr 1:167,508,598...167,511,530

G

protein tyrosine kinase 2

multiple interactions

Puromycin Aminonucleoside results in increased expression of and results in increased phosphorylation of PTK2 protein

NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783

G

protein tyrosine phosphatase, receptor type, O

affects expression

Puromycin Aminonucleoside affects the expression of PTPRO mRNA; Puromycin Aminonucleoside affects the expression of PTPRO protein

NCBI chr 4:170,164,071...170,374,790
Ensembl chr 4:170,164,431...170,374,771

G

retinoic acid receptor, alpha

increases expression

Puromycin Aminonucleoside results in increased expression of RARA mRNA; Puromycin Aminonucleoside results in increased expression of RARA protein

NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142

G

RB binding protein 7, chromatin remodeling factor

decreases expression

Puromycin Aminonucleoside results in decreased expression of RBBP7 protein

NCBI chr X:31,913,080...31,931,245
Ensembl chr X:31,913,081...31,931,226

G

renin

multiple interactions
increases expression
affects expression

Puromycin Aminonucleoside affects the expression of and affects the activity of REN protein; Puromycin Aminonucleoside results in increased expression of and results in increased activity of REN protein
Puromycin Aminonucleoside results in increased expression of REN protein
Puromycin Aminonucleoside affects the expression of REN protein

PMID:2236972 PMID:2267444 PMID:8446257 PMID:9171944

NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489

G

ras homolog family member A

multiple interactions
increases expression

fluvastatin inhibits the reaction [Puromycin Aminonucleoside results in increased expression of RHOA protein]

NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746

G

sodium channel epithelial 1 subunit alpha

affects expression
multiple interactions
decreases expression
affects localization

Puromycin Aminonucleoside affects the expression of SCNN1A mRNA
Puromycin Aminonucleoside results in increased expression of and results in increased localization of SCNN1A protein
Puromycin Aminonucleoside results in decreased expression of SCNN1A mRNA
Puromycin Aminonucleoside affects the localization of SCNN1A protein

PMID:12653683 PMID:15075188 PMID:16020936 PMID:16267158

NCBI chr 4:158,122,962...158,146,184
Ensembl chr 4:158,122,962...158,146,181

G

sodium channel epithelial 1 subunit beta

affects expression
increases expression
decreases expression
multiple interactions
affects localization

Puromycin Aminonucleoside affects the expression of SCNN1B mRNA
Puromycin Aminonucleoside results in increased expression of SCNN1B mRNA
Puromycin Aminonucleoside results in decreased expression of SCNN1B mRNA
Puromycin Aminonucleoside results in increased expression of and results in increased localization of SCNN1B protein
Puromycin Aminonucleoside affects the localization of SCNN1B protein

PMID:12653683 PMID:15075188 PMID:16020936 PMID:16267158

NCBI chr 1:176,430,063...176,484,451
Ensembl chr 1:176,430,103...176,484,451

G

sodium channel epithelial 1 subunit gamma

multiple interactions
increases expression
decreases expression

Puromycin Aminonucleoside affects the localization of and affects the expression of SCNN1G protein; Puromycin Aminonucleoside results in increased expression of and results in increased localization of SCNN1G protein
Puromycin Aminonucleoside results in increased expression of SCNN1G mRNA
Puromycin Aminonucleoside results in decreased expression of SCNN1G mRNA

PMID:12653683 PMID:15075188 PMID:16020936 PMID:16267158

NCBI chr 1:176,304,942...176,338,816
Ensembl chr 1:176,304,942...176,338,816

G

serpin family E member 1

multiple interactions
increases expression

pioglitazone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of SERPINE1 mRNA]

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

G

solute carrier family 12 member 1

decreases expression

Puromycin Aminonucleoside results in decreased expression of SLC12A1 protein

NCBI chr 3:112,406,140...112,482,913
Ensembl chr 3:112,406,140...112,482,899

G

solute carrier family 12 member 3

decreases expression

Puromycin Aminonucleoside results in decreased expression of SLC12A3 protein

NCBI chr19:10,630,651...10,679,250
Ensembl chr19:10,631,393...10,669,091

G

solute carrier family 22 member 2

affects expression

Puromycin Aminonucleoside affects the expression of SLC22A2 mRNA

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

G

solute carrier family 29 member 4

increases response to substance

SLC29A4 results in increased susceptibility to Puromycin Aminonucleoside

NCBI chr12:11,853,540...11,884,660
Ensembl chr12:11,853,540...11,874,834

G

solute carrier family 5 member 3

increases expression

Puromycin Aminonucleoside results in increased expression of SLC5A3 mRNA

NCBI chr11:31,313,847...31,316,293
Ensembl chr11:31,295,476...31,318,883

G

solute carrier family 9 member A3

multiple interactions
decreases expression
affects expression

[piperine co-treated with Cimetidine co-treated with Pyruvates] inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of SLC9A3 protein]
Puromycin Aminonucleoside affects the expression of SLC9A3 protein

PMID:12191963 PMID:12806184 PMID:15075188

NCBI chr 1:29,124,633...29,167,912
Ensembl chr 1:29,124,674...29,167,417

G

SMAD family member 1

increases expression

Puromycin Aminonucleoside results in increased expression of SMAD1 mRNA

NCBI chr19:28,513,130...28,573,665
Ensembl chr19:28,513,131...28,573,651

G

superoxide dismutase 2

affects expression
decreases expression
multiple interactions

Puromycin Aminonucleoside affects the expression of SOD2 protein
Puromycin Aminonucleoside results in decreased expression of SOD2 protein
[Methylprednisolone co-treated with Puromycin Aminonucleoside] results in increased activity of SOD2 protein

PMID:1942778 PMID:19264907

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

superoxide dismutase 3

decreases expression

Puromycin Aminonucleoside results in decreased expression of SOD3 mRNA

NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990

G

sperm microtubule inner protein 11

multiple interactions
affects expression
decreases phosphorylation
decreases expression

1,25-dihydroxyvitamin D inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of NPHS1 mRNA]; 1,25-dihydroxyvitamin D inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of NPHS1 protein]; Celecoxib inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of NPHS1 mRNA]; fasudil inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of NPHS1 protein]; Fluvastatin inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of NPHS1 mRNA]; Mercuric Chloride promotes the reaction [Puromycin Aminonucleoside results in decreased expression of NPHS1 protein]; Puromycin Aminonucleoside affects the expression of and affects the localization of NPHS1 protein; Puromycin Aminonucleoside promotes the reaction [Mercuric Chloride results in decreased expression of NPHS1 mRNA]; Tretinoin inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of NPHS1 mRNA]; Tretinoin inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of NPHS1 protein]; triptolide inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of NPHS1 protein]
Puromycin Aminonucleoside affects the expression of NPHS1 mRNA; Puromycin Aminonucleoside affects the expression of NPHS1 protein
Puromycin Aminonucleoside results in decreased phosphorylation of NPHS1 protein
Puromycin Aminonucleoside results in decreased expression of NPHS1; Puromycin Aminonucleoside results in decreased expression of NPHS1 mRNA; Puromycin Aminonucleoside results in decreased expression of NPHS1 protein

PMID:10792613 PMID:11012881 PMID:12012391 PMID:12065681 PMID:12386277 More...

NCBI chr 7:129,720,950...129,742,485
Ensembl chr 7:129,720,950...129,742,485

G

secreted phosphoprotein 1

multiple interactions
increases expression

Drugs, Chinese Herbal inhibits the reaction [Puromycin Aminonucleoside results in increased expression of SPP1 protein]; fluvastatin inhibits the reaction [Puromycin Aminonucleoside results in increased expression of SPP1 mRNA]
Puromycin Aminonucleoside results in increased expression of SPP1 mRNA; Puromycin Aminonucleoside results in increased expression of SPP1 protein

PMID:14738908 PMID:16452496

NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162

G

SRC proto-oncogene, non-receptor tyrosine kinase

multiple interactions

Puromycin Aminonucleoside results in increased expression of and results in increased phosphorylation of SRC protein

NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476

G

steroidogenic acute regulatory protein

multiple interactions
decreases expression

[FSHB protein co-treated with CGB3 protein] inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of STAR mRNA]

NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672

G

synaptopodin

decreases expression

Puromycin Aminonucleoside results in decreased expression of SYNPO protein

NCBI chr18:54,048,299...54,106,388
Ensembl chr18:54,026,152...54,102,126

G

transgelin

increases expression

Puromycin Aminonucleoside results in increased expression of TAGLN mRNA; Puromycin Aminonucleoside results in increased expression of TAGLN protein

NCBI chr 8:46,224,939...46,230,413
Ensembl chr 8:46,222,472...46,230,668

G

TEK receptor tyrosine kinase

decreases expression

Puromycin Aminonucleoside results in decreased expression of TEK mRNA

NCBI chr 5:109,607,077...109,733,805
Ensembl chr 5:109,607,077...109,733,804

G

transferrin

increases expression

Puromycin Aminonucleoside results in increased expression of TF mRNA

NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511

G

transcription factor A, mitochondrial

affects expression

Puromycin Aminonucleoside affects the expression of TFAM mRNA

NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292

G

transforming growth factor, beta 1

multiple interactions
increases expression
affects expression

Celecoxib inhibits the reaction [Puromycin Aminonucleoside results in increased expression of TGFB1 mRNA]; Drugs, Chinese Herbal inhibits the reaction [Puromycin Aminonucleoside results in increased expression of TGFB1 protein]; Masoprocol inhibits the reaction [Puromycin Aminonucleoside results in increased expression of TGFB1 mRNA]
Puromycin Aminonucleoside results in increased expression of TGFB1 mRNA; Puromycin Aminonucleoside results in increased expression of TGFB1 protein
Puromycin Aminonucleoside affects the expression of TGFB1 mRNA

PMID:9527400 PMID:12397044 PMID:14738908 PMID:19194550 PMID:19594554

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

TIMP metallopeptidase inhibitor 1

multiple interactions
increases expression

FR 139317 inhibits the reaction [Puromycin Aminonucleoside results in increased expression of TIMP1 mRNA]

NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664

G

tight junction protein 1

multiple interactions
increases expression
affects localization

Cyclosporine inhibits the reaction [Puromycin Aminonucleoside results in increased expression of TJP1 protein]
Puromycin Aminonucleoside affects the localization of TJP1 protein

PMID:15744817 PMID:15798086

NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432

G

tumor necrosis factor

multiple interactions
increases expression

Methylprednisolone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of TNF mRNA]

PMID:8384958 PMID:17457379

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

troponin C1, slow skeletal and cardiac type

decreases expression

Puromycin Aminonucleoside results in decreased expression of TNNC1 mRNA

NCBI chr16:6,400,801...6,405,634
Ensembl chr16:6,402,171...6,405,634

G

tumor protein p53

multiple interactions
increases expression

1,3-dimethylthiourea inhibits the reaction [Puromycin Aminonucleoside results in increased expression of TP53 protein]; Melatonin inhibits the reaction [Puromycin Aminonucleoside results in increased expression of TP53 protein]
Puromycin Aminonucleoside results in increased expression of TRP53 protein
1,3-dimethylthiourea inhibits the reaction [Puromycin Aminonucleoside results in increased expression of TRP53 protein]; Dexamethasone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of TRP53 protein]

PMID:14993511 PMID:15113391 PMID:15987750 PMID:16152783 PMID:17035936

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

transthyretin

increases expression

Puromycin Aminonucleoside results in increased expression of TTR protein

NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008

G

uncoupling protein 3

decreases expression

Puromycin Aminonucleoside results in decreased expression of UCP3 protein

NCBI chr 1:154,815,777...154,828,764
Ensembl chr 1:154,815,777...154,828,762

G

versican

decreases expression

Puromycin Aminonucleoside results in decreased expression of VCAN mRNA; Puromycin Aminonucleoside results in decreased expression of VCAN protein

NCBI chr 2:20,761,718...20,860,637
Ensembl chr 2:20,761,718...20,860,637

G

vinculin

affects localization
increases expression

Puromycin Aminonucleoside affects the localization of VCL protein
Puromycin Aminonucleoside results in increased expression of VCL mRNA; Puromycin Aminonucleoside results in increased expression of VCL protein

NCBI chr15:3,265,776...3,355,586
Ensembl chr15:3,265,815...3,355,606

G

vascular endothelial growth factor A

affects expression
increases expression

Puromycin Aminonucleoside affects the expression of VEGFA mRNA
Puromycin Aminonucleoside results in increased expression of VEGFA protein

PMID:11744811 PMID:14752241

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

vimentin

multiple interactions
increases expression

fluvastatin inhibits the reaction [Puromycin Aminonucleoside results in increased expression of VIM mRNA]

NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187

G

WT1 interacting protein

affects localization

Puromycin Aminonucleoside affects the localization of WTIP protein

NCBI chr 1:86,731,214...86,764,939
Ensembl chr 1:86,731,265...86,765,014

G

X-C motif chemokine ligand 1

affects expression

Puromycin Aminonucleoside affects the expression of XCL1 mRNA

NCBI chr13:77,248,687...77,252,343
Ensembl chr13:77,248,717...77,252,329

G

xanthine dehydrogenase

increases activity
multiple interactions

Puromycin Aminonucleoside results in increased activity of XDH
[Tungsten co-treated with Puromycin Aminonucleoside] results in decreased activity of XDH protein

PMID:7583048 PMID:11041286

NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268

3'-phospho-5'-adenylyl sulfate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

multiple interactions

[NADP co-treated with Uridine Diphosphate Glucuronic Acid co-treated with Phosphoadenosine Phosphosulfate] promotes the reaction [[Enzymes and Coenzymes results in increased metabolism of diosbulbin B] inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]]; [NADP co-treated with Uridine Diphosphate Glucuronic Acid co-treated with Phosphoadenosine Phosphosulfate] promotes the reaction [[Enzymes and Coenzymes results in increased metabolism of saikogenin A analog] inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]]; [NADP co-treated with Uridine Diphosphate Glucuronic Acid co-treated with Phosphoadenosine Phosphosulfate] promotes the reaction [[Enzymes and Coenzymes results in increased metabolism of saikogenin A] inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]]

NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730

G

N-acetyltransferase 2

multiple interactions

[NAT2 protein co-treated with Acetyl Coenzyme A] promotes the reaction [[SULT1A2 protein co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone]

NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520

G

NAD(P)H quinone dehydrogenase 1

multiple interactions

[NQO1 protein co-treated with NADP co-treated with Phosphoadenosine Phosphosulfate co-treated with SULT1A1 protein] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

purinergic receptor P2Y1

decreases activity

Phosphoadenosine Phosphosulfate results in decreased activity of P2RY1 protein

NCBI chr 2:145,241,975...145,248,186
Ensembl chr 2:145,241,849...145,248,457

G

sulfotransferase family 1A member 1

multiple interactions
increases sulfation

2,2',3,4,4',5',6-heptabromodiphenyl ether inhibits the reaction [[Estradiol co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of SULT1A1 protein]; 2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [[Estradiol co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of SULT1A1 protein]; [NQO1 protein co-treated with NADP co-treated with Phosphoadenosine Phosphosulfate co-treated with SULT1A1 protein] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone; Halogenated Diphenyl Ethers analog inhibits the reaction [[Estradiol co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of SULT1A1 protein]; pentabrominated diphenyl ether 100 inhibits the reaction [[Estradiol co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of SULT1A1 protein]; Pentachlorophenol inhibits the reaction [[Estradiol co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of SULT1A1 protein]; tetrabromobisphenol A inhibits the reaction [[Estradiol co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of SULT1A1 protein]; tribromodiphenyl ether 28 inhibits the reaction [[Estradiol co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of SULT1A1 protein]
SULT1A1 protein results in increased sulfation of Phosphoadenosine Phosphosulfate

PMID:11425650 PMID:16601080 PMID:20545351

NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562

G

sulfotransferase family 2A member 1

multiple interactions

[Phosphoadenosine Phosphosulfate co-treated with SULT2A1 protein] affects the sulfation of Ethinyl Estradiol; Celecoxib affects the reaction [[Phosphoadenosine Phosphosulfate co-treated with SULT2A1 protein] affects the sulfation of Ethinyl Estradiol]; SULT2A1 protein affects the metabolism of [Phosphoadenosine Phosphosulfate co-treated with Ethinyl Estradiol]

NCBI chr 1:75,451,178...75,508,113
Ensembl chr 1:74,911,100...75,508,134

3-iodobenzyl-5'-N-methylcarboxamidoadenosine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adenosine A3 receptor

multiple interactions

2,3-diethyl-4,5-dipropyl-6-phenylpyridine-3-thiocarboxylate-5-carboxylate inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA3 mRNA]]; 2,3-diethyl-4,5-dipropyl-6-phenylpyridine-3-thiocarboxylate-5-carboxylate inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA3 protein]]; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine binds to and results in increased activity of ADORA3 protein; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA3 mRNA]; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA3 protein]
[N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine binds to and results in increased activity of ADORA3 protein] which results in decreased susceptibility to Dizocilpine Maleate; [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine binds to and results in increased activity of ADORA3 protein] which results in decreased susceptibility to Scopolamine; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine binds to and results in increased activity of ADORA3 protein

PMID:12672554 PMID:15452191 PMID:19966059

NCBI chr 2:193,352,759...193,392,946
Ensembl chr 2:193,388,713...193,392,357

G

AKT serine/threonine kinase 1

multiple interactions

Pertussis Toxin inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in increased phosphorylation of AKT1 protein]; wortmannin inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in increased phosphorylation of AKT1 protein]

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

baculoviral IAP repeat-containing 3

decreases expression
decreases response to substance

N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of BIRC3 mRNA
BIRC3 protein results in decreased susceptibility to N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine

NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802

G

baculoviral IAP repeat-containing 5

decreases response to substance

BIRC5 protein results in decreased susceptibility to N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of FOS mRNA]

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

interleukin 12A

multiple interactions

N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of [IL12A protein binds to IL12B protein]; Pertussis Toxin inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of [IL12A protein binds to IL12B protein]]; wortmannin inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of [IL12A protein binds to IL12B protein]]

NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734

G

interleukin 12B

multiple interactions

N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of [IL12A protein binds to IL12B protein]; Pertussis Toxin inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of [IL12A protein binds to IL12B protein]]; Wortmannin inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of [IL12A protein binds to IL12B protein]]

NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903

G

NLR family, apoptosis inhibitory protein 6

decreases response to substance
decreases expression

NAIP protein results in decreased susceptibility to N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine
N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of NAIP mRNA

NCBI chr 2:31,507,423...31,559,098
Ensembl chr 2:31,507,424...31,570,542

G

natriuretic peptide A

multiple interactions

2,3-diethyl-4,5-dipropyl-6-phenylpyridine-3-thiocarboxylate-5-carboxylate inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]

PMID:15452191 PMID:19966059

NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351

G

regulator of G-protein signaling 2

multiple interactions

N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of RGS2 mRNA]

NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385

G

solute carrier family 9 member A1

multiple interactions

N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of SLC9A1 protein]

NCBI chr 5:145,576,341...145,629,630
Ensembl chr 5:145,576,334...145,629,624

3-methyladenine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

actin alpha 2, smooth muscle

multiple interactions

3-methyladenine inhibits the reaction [Arsenic Trioxide results in increased expression of ACTA2 protein]; 3-methyladenine inhibits the reaction [sodium arsenite results in increased expression of ACTA2 protein]

PMID:30677399 PMID:38477077

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

apoptosis inducing factor, mitochondria associated 1

increases expression

3-methyladenine results in increased expression of AIFM1 protein

NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256

G

AKT serine/threonine kinase 1

decreases phosphorylation
multiple interactions

3-methyladenine results in decreased phosphorylation of AKT1 protein
3-methyladenine inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of AKT1 protein]

PMID:16882451 PMID:32043704

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

apoptotic peptidase activating factor 1

multiple interactions

3-methyladenine inhibits the reaction [Diosgenin inhibits the reaction [alpha-Chlorohydrin results in increased expression of APAF1 protein]]

NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540

G

apolipoprotein D

affects localization

3-methyladenine affects the localization of APOD protein

NCBI chr11:69,431,261...69,452,306
Ensembl chr11:69,431,260...69,452,305

G

amyloid beta precursor protein

multiple interactions

[Hydrogen Peroxide co-treated with 3-methyladenine] results in increased expression of APP protein

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

autophagy related 4A, cysteine peptidase

decreases expression

3-methyladenine results in decreased expression of ATG4A mRNA

NCBI chr X:104,665,345...104,765,271
Ensembl chr X:104,665,345...104,765,268

G

autophagy related 4B, cysteine peptidase

decreases expression

3-methyladenine results in decreased expression of ATG4B mRNA

NCBI chr 9:94,282,417...94,314,109
Ensembl chr 9:94,282,509...94,314,103

G

autophagy related 5

multiple interactions
decreases expression
increases expression

3-methyladenine inhibits the reaction [Alpha-Amanitin results in increased expression of ATG5 protein]; 3-methyladenine inhibits the reaction [hydroxyethyl methacrylate results in increased expression of ATG5 protein]; 3-methyladenine inhibits the reaction [Particulate Matter results in increased expression of ATG5 protein]; ATG5 protein affects the reaction [3-methyladenine results in increased activity of CASP3 protein]
3-methyladenine results in decreased expression of ATG5 protein
3-methyladenine results in increased expression of ATG5 protein
3-methyladenine affects the reaction [Dibutyl Phthalate results in increased expression of ATG5 protein]; 3-methyladenine affects the reaction [T-2 Toxin affects the expression of ATG5 protein]; 3-methyladenine inhibits the reaction [Arsenic Trioxide results in increased expression of ATG5 mRNA]
3-methyladenine results in decreased expression of ATG5 mRNA; 3-methyladenine results in decreased expression of ATG5 protein
3-methyladenine inhibits the reaction [aristolochic acid I results in increased expression of ATG5 protein]; 3-methyladenine inhibits the reaction [N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide inhibits the reaction [Glucose results in decreased expression of ATG5 protein]]; 3-methyladenine inhibits the reaction [sphingosine 1-phosphate results in increased expression of ATG5 protein]; 3-methyladenine promotes the reaction [Lipopolysaccharides results in increased expression of ATG5 protein]

PMID:18818525 PMID:23939141 PMID:28184909 PMID:29128638 PMID:29781141 More...

NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209

G

autophagy related 7

multiple interactions

3-methyladenine inhibits the reaction [1-nitropyrene results in increased expression of ATG7 mRNA]; 3-methyladenine inhibits the reaction [Alpha-Amanitin results in increased expression of ATG7 protein]; 3-methyladenine inhibits the reaction [beta-lapachone results in increased expression of ATG7 protein]; 3-methyladenine inhibits the reaction [rottlerin results in increased expression of ATG7 protein]; [Taurine co-treated with 3-methyladenine] inhibits the reaction [1-nitropyrene results in increased expression of ATG7 mRNA]
3-methyladenine inhibits the reaction [Arsenic Trioxide results in increased expression of ATG7 mRNA]

PMID:22902833 PMID:29078374 PMID:33462182 PMID:37329965 PMID:38218311

NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593

G

ATP synthase peripheral stalk subunit d

multiple interactions

[3-methyladenine co-treated with Taurine] inhibits the reaction [1-nitropyrene results in decreased expression of ATP5PD mRNA]

NCBI chr10:100,657,700...100,662,960
Ensembl chr10:100,657,708...100,663,479

G

BCL2 associated X, apoptosis regulator

multiple interactions

3-methyladenine inhibits the reaction [citreoviridin results in increased expression of BAX protein]; 3-methyladenine inhibits the reaction [osthol inhibits the reaction [Antineoplastic Agents, Immunological results in increased expression of BAX protein]]; 3-methyladenine promotes the reaction [4-nonylphenol results in increased expression of BAX protein]
3-methyladenine inhibits the reaction [dibromoacetonitrile results in increased expression of BAX protein]
3-methyladenine inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]; 3-methyladenine inhibits the reaction [Nicotine results in increased expression of BAX protein]

PMID:26804764 PMID:31419397 PMID:32043704 PMID:33010382 PMID:37769856 More...

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions

3-methyladenine inhibits the reaction [alisol A 24-acetate results in decreased expression of BCL2 protein]; 3-methyladenine inhibits the reaction [alisol B 23-acetate results in decreased expression of BCL2 protein]; 3-methyladenine inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2]; 3-methyladenine inhibits the reaction [Artesunate results in decreased expression of BCL2 protein]; 3-methyladenine inhibits the reaction [beta-ionone results in decreased expression of BCL2 protein]; 3-methyladenine inhibits the reaction [Nicotine results in decreased expression of BCL2 protein]; 3-methyladenine promotes the reaction [Silybin results in decreased expression of BCL2 protein]; [3-methyladenine co-treated with Amiodarone] results in decreased expression of BCL2 protein
3-methyladenine inhibits the reaction [Alpha-Amanitin results in decreased expression of BCL2 protein]; 3-methyladenine inhibits the reaction [dibromoacetonitrile results in decreased expression of BCL2 protein]
3-methyladenine inhibits the reaction [citreoviridin results in decreased expression of BCL2 protein]

PMID:23912912 PMID:25110043 PMID:28408883 PMID:31419397 PMID:33002460 More...

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

multiple interactions
increases expression

3-methyladenine inhibits the reaction [Fluorouracil results in increased expression of BCL2L1 protein]
3-methyladenine results in increased expression of BCL2L1 mRNA

PMID:19116755 PMID:21681844

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479

G

beclin 1

multiple interactions
decreases expression
affects response to substance

3-methyladenine inhibits the reaction [2,4,4'-trichlorobiphenyl results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [2,5,2',5'-tetrachlorobiphenyl results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [4-amino-2-trifluoromethyl-phenyl retinate results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [Alpha-Amanitin results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [Arsenic Trioxide results in increased expression of BECN1]; 3-methyladenine inhibits the reaction [BECN1 protein results in decreased susceptibility to Staurosporine]; 3-methyladenine inhibits the reaction [Caffeine results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [di-n-propyldithiocarbamate results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [E platinum results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Cisplatin results in decreased expression of BECN1 protein]]; 3-methyladenine inhibits the reaction [gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human promotes the reaction [BECN1 protein binds to PIK3C3 protein]]]; 3-methyladenine inhibits the reaction [Hydrogen Peroxide promotes the reaction [BECN1 protein binds to PIK3C3 protein]]; 3-methyladenine inhibits the reaction [Hydrogen Peroxide results in increased expression of BECN1 mRNA]; 3-methyladenine inhibits the reaction [Hydrogen Peroxide results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [hydroxyethyl methacrylate results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [LGALS1 protein results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [malondialdehyde-low density lipoprotein, human promotes the reaction [BECN1 protein binds to PIK3C3 protein]]; 3-methyladenine inhibits the reaction [polyphyllin I results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [Potassium Iodide results in increased expression of BECN1 mRNA]; 3-methyladenine inhibits the reaction [Potassium Iodide results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [rottlerin results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [Silicon Dioxide promotes the reaction [PIK3C3 protein binds to BECN1 protein]]; 3-methyladenine inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of BECN1 protein]; Ropivacaine inhibits the reaction [3-methyladenine results in decreased expression of BECN1 protein]
3-methyladenine affects the reaction [Dibutyl Phthalate results in increased expression of BECN1 protein]; 3-methyladenine affects the reaction [T-2 Toxin affects the expression of BECN1 protein]; 3-methyladenine inhibits the reaction [anemoside B4 inhibits the reaction [Lipopolysaccharides results in decreased expression of BECN1 protein]]; 3-methyladenine inhibits the reaction [Arsenic Trioxide results in increased expression of BECN1 mRNA]; 3-methyladenine inhibits the reaction [Busulfan results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [Caffeine results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [dibromoacetonitrile results in increased expression of BECN1 protein]
3-methyladenine inhibits the reaction [2,4,4'-trichlorobiphenyl results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [2,5,2',5'-tetrachlorobiphenyl results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [4-nonylphenol results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [Acrylamide results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of BECN1 protein]]; 3-methyladenine inhibits the reaction [glycidamide results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [Mirtazapine results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [osthol inhibits the reaction [Antineoplastic Agents, Immunological results in decreased expression of BECN1 protein]]; 3-methyladenine inhibits the reaction [T-2 Toxin results in increased expression of BECN1 mRNA]
BECN1 protein affects the susceptibility to 3-methyladenine
3-methyladenine results in decreased expression of BECN1 mRNA; 3-methyladenine results in decreased expression of BECN1 protein

PMID:16497721 PMID:18619688 PMID:20525898 PMID:22322152 PMID:22902833 More...

NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742

G

BH3 interacting domain death agonist

increases cleavage

3-methyladenine results in increased cleavage of BID protein

NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720

G

baculoviral IAP repeat-containing 5

multiple interactions

3-methyladenine inhibits the reaction [sepantronium results in decreased expression of BIRC5 protein]

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

G

BCL2 interacting protein 3

decreases expression

3-methyladenine results in decreased expression of BNIP3 protein

NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359

G

caspase 1

multiple interactions

3-methyladenine inhibits the reaction [[Arsenic Trioxide co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased cleavage of CASP1 protein]; 3-methyladenine inhibits the reaction [Patulin results in increased expression of CASP1 protein]; 3-methyladenine promotes the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased cleavage of CASP1 protein]; 3-methyladenine promotes the reaction [Acrolein results in increased expression of CASP1 protein]
3-methyladenine affects the reaction [[HU 308 co-treated with Dextran Sulfate] affects the cleavage of CASP1 protein]
3-methyladenine promotes the reaction [[Zearalenone co-treated with Lipopolysaccharides] results in increased expression of CASP1 protein modified form]; 3-methyladenine promotes the reaction [Lipopolysaccharides results in increased cleavage of CASP1 protein]

PMID:27611972 PMID:30205151 PMID:30237538 PMID:31586597 PMID:33217525 More...

NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383

G

caspase 3

multiple interactions
increases cleavage
increases activity
increases expression

3-methyladenine inhibits the reaction [Alpha-Amanitin results in increased cleavage of CASP3 protein]; 3-methyladenine inhibits the reaction [procyanidin B2 inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP3 mRNA]]; 3-methyladenine promotes the reaction [Fluorouracil results in increased cleavage of and results in increased activity of CASP3 protein]
3-methyladenine results in increased cleavage of CASP3 protein
3-methyladenine inhibits the reaction [Aminolevulinic Acid analog results in increased activity of CASP3 protein]; 3-methyladenine inhibits the reaction [osthol inhibits the reaction [Antineoplastic Agents, Immunological results in increased expression of CASP3 protein]]; 3-methyladenine inhibits the reaction [Oxidopamine results in increased expression of CASP3 protein modified form]; 3-methyladenine inhibits the reaction [sodium arsenite results in increased activity of CASP3 protein]; 3-methyladenine promotes the reaction [4-nonylphenol results in increased cleavage of CASP3 protein]; 3-methyladenine promotes the reaction [Methamphetamine results in increased cleavage of CASP3 protein]; 3-methyladenine promotes the reaction [Staurosporine results in increased cleavage of CASP3 protein]; 3-methyladenine promotes the reaction [T-2 Toxin results in increased expression of CASP3 protein modified form]
3-methyladenine inhibits the reaction [Acrolein results in increased cleavage of CASP3 protein]; 3-methyladenine inhibits the reaction [Artesunate results in increased cleavage of CASP3 protein]; 3-methyladenine inhibits the reaction [Biological Products results in increased cleavage of CASP3 protein]; 3-methyladenine inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein modified form]; 3-methyladenine inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of CASP3 protein]; 3-methyladenine inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP3 protein]; 3-methyladenine inhibits the reaction [perfluorooctane sulfonic acid results in increased activity of CASP3 protein]; 3-methyladenine inhibits the reaction [polyphyllin I results in increased expression of CASP3 protein modified form]; 3-methyladenine inhibits the reaction [tetrandrine results in increased cleavage of CASP3 protein]; 3-methyladenine promotes the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP3 protein]]; 3-methyladenine promotes the reaction [ABT-737 results in increased cleavage of CASP3 protein]; 3-methyladenine promotes the reaction [Amiodarone results in increased cleavage of CASP3 protein]; 3-methyladenine promotes the reaction [astin B results in increased cleavage of CASP3 protein]; 3-methyladenine promotes the reaction [Biological Products results in increased expression of and results in increased cleavage of CASP3 protein]; 3-methyladenine promotes the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP3 protein]]; 3-methyladenine promotes the reaction [Celecoxib results in increased cleavage of CASP3 protein]; 3-methyladenine promotes the reaction [dihydrocapsaicin results in increased activity of CASP3 protein]; 3-methyladenine promotes the reaction [embelin results in increased degradation of CASP3 protein]; 3-methyladenine promotes the reaction [Fluorouracil results in increased cleavage of and results in increased activity of CASP3 protein]; 3-methyladenine promotes the reaction [fosbretabulin results in increased cleavage of CASP3 protein]; 3-methyladenine promotes the reaction [MAP3K5 protein results in increased activity of CASP3 protein]; 3-methyladenine promotes the reaction [Paraquat results in increased activity of CASP3 protein]; 3-methyladenine promotes the reaction [Potassium Dichromate results in increased expression of CASP3 protein modified form]; 3-methyladenine promotes the reaction [SC-66 compound results in increased cleavage of CASP3 protein]; 3-methyladenine promotes the reaction [Silybin results in decreased expression of and results in increased cleavage of CASP3 protein]; 3-methyladenine promotes the reaction [tetrandrine results in increased cleavage of CASP3 protein]; 3-methyladenine promotes the reaction [usnic acid results in increased activity of CASP3 protein]; 3-methyladenine results in increased expression of and results in increased cleavage of CASP3 protein; [3-methyladenine co-treated with cobaltous chloride co-treated with TP53 gene mutant form] results in increased activity of CASP3 protein; [3-methyladenine co-treated with fosbretabulin] results in increased cleavage of CASP3 protein; [3-methyladenine co-treated with Miconazole] results in increased cleavage of CASP3 protein; [3-methyladenine co-treated with vandetanib] results in increased activity of CASP3 protein; ATG5 protein affects the reaction [3-methyladenine results in increased activity of CASP3 protein]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [3-methyladenine promotes the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP3 protein]]]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [3-methyladenine promotes the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP3 protein]]]; benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [3-methyladenine promotes the reaction [dihydrocapsaicin results in increased activity of CASP3 protein]]; benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [dihydrocapsaicin promotes the reaction [3-methyladenine results in increased activity of CASP3 protein]]; benzyloxycarbonyl-valyl-alanyl-aspartyl-fluoromethane inhibits the reaction [3-methyladenine results in increased activity of CASP3 protein]; dihydrocapsaicin promotes the reaction [3-methyladenine results in increased activity of CASP3 protein]
3-methyladenine results in increased expression of CASP3 mRNA

PMID:16497721 PMID:17341480 PMID:18818525 PMID:19116755 PMID:19139269 More...

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 4

increases activity

3-methyladenine results in increased activity of CASP4 protein

NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092

G

caspase 7

increases activity
multiple interactions

3-methyladenine results in increased activity of CASP7 protein
3-methyladenine promotes the reaction [usnic acid results in increased activity of CASP7 protein]

PMID:20371669 PMID:25078063

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

G

caspase 8

multiple interactions

3-methyladenine promotes the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP8 protein]]; 3-methyladenine promotes the reaction [ABT-737 results in increased cleavage of CASP8 protein]; 3-methyladenine promotes the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP8 protein]]; 3-methyladenine promotes the reaction [Celecoxib results in increased cleavage of CASP8 protein]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [3-methyladenine promotes the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP8 protein]]]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [3-methyladenine promotes the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP8 protein]]]

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

multiple interactions

3-methyladenine inhibits the reaction [Acrolein results in increased cleavage of CASP9 protein]; 3-methyladenine inhibits the reaction [Cannabidiol results in increased activity of CASP9 protein]; 3-methyladenine inhibits the reaction [Diosgenin inhibits the reaction [alpha-Chlorohydrin results in increased activity of CASP9 protein]]; 3-methyladenine inhibits the reaction [Diosgenin inhibits the reaction [alpha-Chlorohydrin results in increased cleavage of CASP9 protein]]; 3-methyladenine inhibits the reaction [Doxorubicin results in increased expression of CASP9 protein modified form]; 3-methyladenine inhibits the reaction [hydroxyethyl methacrylate results in increased expression of CASP9 mRNA]; 3-methyladenine promotes the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP9 protein]]; 3-methyladenine promotes the reaction [ABT-737 results in increased cleavage of CASP9 protein]; 3-methyladenine promotes the reaction [BO-1012 results in increased cleavage of CASP9 protein]; 3-methyladenine promotes the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP9 protein]]; 3-methyladenine promotes the reaction [Celecoxib results in increased cleavage of CASP9 protein]; 3-methyladenine promotes the reaction [embelin results in increased degradation of CASP9 protein]; [3-methyladenine co-treated with Potassium Dichromate] results in increased expression of CASP9 protein modified form; [3-methyladenine co-treated with vandetanib] results in increased activity of CASP9 protein; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [3-methyladenine promotes the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP9 protein]]]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [3-methyladenine promotes the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP9 protein]]]
3-methyladenine inhibits the reaction [Aminolevulinic Acid analog results in increased activity of CASP9 protein]; 3-methyladenine promotes the reaction [Staurosporine results in increased cleavage of CASP9 protein]

PMID:16497721 PMID:20104024 PMID:20426806 PMID:23799852 PMID:24823293 More...

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

multiple interactions

3-methyladenine inhibits the reaction [anemoside B4 inhibits the reaction [Lipopolysaccharides results in decreased activity of CAT protein]]

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cellular communication network factor 1

multiple interactions

3-methyladenine inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of CCN1 protein]]

NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484

G

cyclin D1

multiple interactions

3-methyladenine inhibits the reaction [[Lactic Acid co-treated with [Cadmium Chloride results in increased abundance of Cadmium]] results in increased expression of CCND1 protein]

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin E1

multiple interactions

3-methyladenine inhibits the reaction [Lactic Acid promotes the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CCNE1 protein]]

NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101

G

cyclin-dependent kinase inhibitor 1A

multiple interactions

3-methyladenine inhibits the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of CDKN1A protein]]; 3-methyladenine inhibits the reaction [Doxorubicin results in increased expression of CDKN1A protein]

PMID:22927544 PMID:30555576

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

caudal type homeo box 2

increases expression

3-methyladenine results in increased expression of CDX2 mRNA

NCBI chr12:7,726,798...7,733,142
Ensembl chr12:7,726,798...7,733,142

G

CCAAT/enhancer binding protein alpha

multiple interactions

[Taurine co-treated with 3-methyladenine] inhibits the reaction [1-nitropyrene results in decreased expression of CEBPA mRNA]

NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412

G

checkpoint kinase 1

multiple interactions

3-methyladenine inhibits the reaction [BO-1012 results in increased phosphorylation of CHEK1 protein]

NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009

G

creatine kinase B

multiple interactions

3-methyladenine inhibits the reaction [citreoviridin results in increased secretion of [CKM protein binds to CKB protein]]

NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315

G

creatine kinase, M-type

multiple interactions

3-methyladenine inhibits the reaction [citreoviridin results in increased secretion of [CKM protein binds to CKB protein]]

NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720

G

collagen type I alpha 1 chain

multiple interactions

3-methyladenine inhibits the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of COL1A1 mRNA]]; 3-methyladenine inhibits the reaction [Mirtazapine results in increased expression of COL1A1 mRNA]; 3-methyladenine inhibits the reaction [sphingosine 1-phosphate results in increased expression of COL1A1 protein]
3-methyladenine inhibits the reaction [sodium arsenite results in increased expression of COL1A1 protein]

PMID:35066094 PMID:37169277 PMID:38477077

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

collagen type I alpha 2 chain

multiple interactions

3-methyladenine promotes the reaction [T-2 Toxin results in decreased expression of COL1A2 protein]

NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867

G

catenin beta 1

multiple interactions

3-methyladenine promotes the reaction [T-2 Toxin results in decreased expression of CTNNB1 protein]

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

cathepsin B

multiple interactions

3-methyladenine inhibits the reaction [[Arsenic Trioxide co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of CTSB protein]; 3-methyladenine inhibits the reaction [[cobaltous chloride co-treated with TP53 gene mutant form] results in increased activity of CTSB protein]; 3-methyladenine inhibits the reaction [Acrolein results in increased expression of CTSB protein]; 3-methyladenine inhibits the reaction [Patulin results in increased secretion of CTSB protein]

PMID:23380477 PMID:29902662 PMID:30237538 PMID:33217525

NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500

G

cathepsin L

multiple interactions

3-methyladenine inhibits the reaction [Cadmium Chloride results in increased cleavage of CTSL protein]

NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548

G

C-X-C motif chemokine ligand 2

multiple interactions

3-methyladenine inhibits the reaction [Particulate Matter results in increased expression of CXCL2 mRNA]; 3-methyladenine inhibits the reaction [Particulate Matter results in increased expression of CXCL2 protein]

NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075

G

C-X-C motif chemokine ligand 3

multiple interactions

3-methyladenine inhibits the reaction [Particulate Matter results in increased expression of CXCL1 mRNA]; 3-methyladenine inhibits the reaction [Particulate Matter results in increased expression of CXCL1 protein]

NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511

G

cytochrome c, somatic

multiple interactions

3-methyladenine promotes the reaction [MAP3K5 protein affects the localization of CYCS protein]

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

DNA-damage inducible transcript 3

multiple interactions

3-methyladenine promotes the reaction [Lipopolysaccharides results in increased expression of DDIT3 protein]

PMID:28245985 PMID:37654027

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

eukaryotic translation initiation factor 2 alpha kinase 3

multiple interactions

[3-methyladenine co-treated with Potassium Dichromate] results in increased expression of EIF2AK3 protein modified form
3-methyladenine promotes the reaction [Lipopolysaccharides results in increased phosphorylation of EIF2AK3 protein]

PMID:32569804 PMID:37654027

NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911

G

eukaryotic translation initiation factor 4E binding protein 1

decreases phosphorylation
multiple interactions

3-methyladenine results in decreased phosphorylation of EIF4EBP1 protein
3-methyladenine inhibits the reaction [Diosgenin promotes the reaction [alpha-Chlorohydrin results in decreased phosphorylation of EIF4EBP1 protein]]

PMID:26804764 PMID:35149085

NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984

G

ELAV like RNA binding protein 1

multiple interactions

3-methyladenine inhibits the reaction [sepantronium results in decreased expression of and results in decreased stability of ELAVL1 mRNA]; 3-methyladenine inhibits the reaction [sepantronium results in decreased expression of ELAVL1 protein]

NCBI chr12:2,640,936...2,684,787
Ensembl chr12:2,645,061...2,684,784

G

enolase 2

multiple interactions

3-methyladenine inhibits the reaction [Sirolimus results in increased expression of ENO2 protein]

NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980

G

fibronectin 1

multiple interactions

3-methyladenine inhibits the reaction [sphingosine 1-phosphate results in increased expression of FN1 protein]; 3-methyladenine inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of and results in increased lipidation of FN1 protein]

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

ferritin heavy chain 1

multiple interactions

3-methyladenine inhibits the reaction [di-n-propyldithiocarbamate results in decreased expression of FTH1 protein]
3-methyladenine inhibits the reaction [Busulfan results in decreased expression of FTH1 protein]
3-methyladenine promotes the reaction [erastin results in increased expression of FTH1 protein]

PMID:32687844 PMID:32937103 PMID:38220133

NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424

G

GABA type A receptor-associated protein

decreases expression

3-methyladenine results in decreased expression of GABARAP mRNA

NCBI chr10:54,714,777...54,718,099
Ensembl chr10:54,714,198...54,717,765

G

growth associated protein 43

multiple interactions

3-methyladenine inhibits the reaction [sodium arsenite results in decreased expression of GAP43]

NCBI chr11:58,376,371...58,470,047
Ensembl chr11:58,376,371...58,470,045

G

gap junction protein, alpha 1

multiple interactions

3-methyladenine inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of GJA1 protein]

NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582

G

glutamic-oxaloacetic transaminase 1

multiple interactions

3-methyladenine inhibits the reaction [Ethanol results in increased secretion of GOT1 protein]

NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633

G

glutamic--pyruvic transaminase

increases expression
multiple interactions

3-methyladenine results in increased expression of GPT protein
3-methyladenine inhibits the reaction [Ethanol results in increased secretion of GPT protein]; TRP53BP2 protein affects the reaction [3-methyladenine results in increased expression of GPT protein]

PMID:31513885 PMID:37898230

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

glutathione peroxidase 4

multiple interactions

3-methyladenine inhibits the reaction [Busulfan results in decreased expression of GPX4 protein]

NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982

G

gasdermin D

multiple interactions

3-methyladenine promotes the reaction [Lipopolysaccharides results in increased expression of GSDMD protein]

NCBI chr 7:107,542,489...107,547,051
Ensembl chr 7:107,542,083...107,547,055

G

glycogen synthase kinase 3 beta

multiple interactions

3-methyladenine inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of GSK3B protein]
3-methyladenine promotes the reaction [T-2 Toxin results in increased expression of GSK3B protein]

PMID:30362509 PMID:36402210

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

glycogen synthase 1

multiple interactions

3-methyladenine inhibits the reaction [Arsenic Trioxide results in decreased phosphorylation of GYS1 protein]

NCBI chr 1:95,915,443...95,935,292
Ensembl chr 1:95,915,443...95,935,292

G

H2A.X variant histone

multiple interactions

3-methyladenine inhibits the reaction [Aflatoxin B1 results in increased expression of H2AX protein]

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239

G

hepatitis A virus cellular receptor 1

multiple interactions

3-methyladenine inhibits the reaction [alisol A 24-acetate results in increased expression of HAVCR1 protein]; 3-methyladenine inhibits the reaction [alisol B 23-acetate results in increased expression of HAVCR1 protein]

NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698

G

hes family bHLH transcription factor 1

multiple interactions

3-methyladenine inhibits the reaction [Dibutyl Phthalate results in decreased expression of HES1 mRNA]; 3-methyladenine inhibits the reaction [Dibutyl Phthalate results in decreased expression of HES1 protein]

NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192

G

hes-related family bHLH transcription factor with YRPW motif 2

multiple interactions

3-methyladenine inhibits the reaction [Dibutyl Phthalate results in decreased expression of HEY2 mRNA]; 3-methyladenine inhibits the reaction [Dibutyl Phthalate results in decreased expression of HEY2 protein]

NCBI chr 1:26,822,131...26,832,218
Ensembl chr 1:26,822,131...26,832,218

G

hypoxia inducible factor 1 subunit alpha

multiple interactions

3-methyladenine inhibits the reaction [CR 3294 results in decreased expression of HIF1A protein]

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

hexokinase 2

multiple interactions
decreases expression

3-methyladenine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HK2 protein]; 3-methyladenine inhibits the reaction [Potassium Dichromate results in increased expression of HK2 protein]; 3-methyladenine promotes the reaction [Silybin results in decreased expression of HK2 protein]; 4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine inhibits the reaction [3-methyladenine results in decreased expression of HK2 protein]

PMID:32569804 PMID:34053323 PMID:34481905 PMID:36336208

NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530

G

high mobility group AT-hook 2

multiple interactions

3-methyladenine inhibits the reaction [HMGA2 protein results in decreased expression of COX4 protein]; 3-methyladenine inhibits the reaction [HMGA2 protein results in decreased expression of ND1 protein]

NCBI chr 7:55,877,145...55,998,813
Ensembl chr 7:55,880,112...55,994,784

G

heat shock protein family A (Hsp70) member 5

multiple interactions

3-methyladenine promotes the reaction [Lipopolysaccharides results in increased expression of HSPA5 protein]; 3-methyladenine promotes the reaction [Potassium Dichromate results in increased expression of HSPA5 protein]

PMID:28245985 PMID:32569804

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

intercellular adhesion molecule 1

multiple interactions

3-methyladenine inhibits the reaction [resveratrol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

interleukin 18

multiple interactions

3-methyladenine inhibits the reaction [Patulin results in increased expression of IL18 protein]; 3-methyladenine promotes the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased expression of IL18 protein]
3-methyladenine inhibits the reaction [sphingosine 1-phosphate results in increased expression of IL18 protein]

PMID:30205151 PMID:33217525 PMID:37169277

NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887

G

interleukin 1 beta

multiple interactions
increases expression

3-methyladenine inhibits the reaction [[Arsenic Trioxide co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IL1B protein]; 3-methyladenine inhibits the reaction [Patulin results in increased expression of IL1B protein]; 3-methyladenine promotes the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased expression of IL1B protein]; 3-methyladenine promotes the reaction [Acrolein results in increased expression of IL1B protein]
3-methyladenine results in increased expression of IL1B mRNA
3-methyladenine affects the reaction [[HU 308 co-treated with Dextran Sulfate] affects the expression of IL1B protein]; 3-methyladenine inhibits the reaction [anemoside B4 inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; TRP53BP2 protein affects the reaction [3-methyladenine results in increased expression of IL1B mRNA]
3-methyladenine inhibits the reaction [lead acetate results in increased expression of IL1B protein]; 3-methyladenine promotes the reaction [[Zearalenone co-treated with Lipopolysaccharides] results in increased expression of IL1B protein modified form]

PMID:27611972 PMID:30205151 PMID:30237538 PMID:31513885 PMID:31586597 More...

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions
increases expression

3-methyladenine inhibits the reaction [1-nitropyrene results in increased secretion of IL6 protein]; 3-methyladenine inhibits the reaction [anemoside B4 inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; [Taurine co-treated with 3-methyladenine] inhibits the reaction [1-nitropyrene results in increased secretion of IL6 protein]; TRP53BP2 protein affects the reaction [3-methyladenine results in increased expression of IL6 mRNA]
3-methyladenine inhibits the reaction [Particulate Matter results in increased expression of IL6 mRNA]; 3-methyladenine inhibits the reaction [Particulate Matter results in increased expression of IL6 protein]; 3-methyladenine inhibits the reaction [Particulate Matter results in increased secretion of IL6 protein]

PMID:28867211 PMID:29078374 PMID:29781141 PMID:31513885 PMID:34051206

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

insulin receptor substrate 1

multiple interactions

3-methyladenine inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of IRS1 protein]

NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122

G

integrin subunit alpha M

multiple interactions

3-methyladenine inhibits the reaction [4-amino-2-trifluoromethyl-phenyl retinate results in increased expression of ITGAM protein]; 3-methyladenine inhibits the reaction [Tretinoin affects the localization of ITGAM protein]; 3-methyladenine inhibits the reaction [Tretinoin results in increased localization of and results in increased expression of ITGAM protein]; [benzyloxycarbonyl-valyl-alanyl-aspartic acid analog co-treated with 3-methyladenine] inhibits the reaction [Tretinoin affects the localization of ITGAM protein]

PMID:20574048 PMID:28130038 PMID:29743969

NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503

G

jagged canonical Notch ligand 1

multiple interactions

3-methyladenine inhibits the reaction [Dibutyl Phthalate results in decreased expression of JAG1 mRNA]

NCBI chr 3:124,406,783...124,442,220
Ensembl chr 3:124,406,794...124,442,209

G

jagged canonical Notch ligand 2

multiple interactions

3-methyladenine inhibits the reaction [Dibutyl Phthalate results in decreased expression of JAG2 mRNA]

NCBI chr 6:131,983,059...132,005,665
Ensembl chr 6:131,983,056...132,005,818

G

Janus kinase 2

decreases phosphorylation

3-methyladenine co-treated with anlotinib decreases phosphorylation of JAK2 protein in lung epithelium

RGD

NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189

G

Kelch-like ECH-associated protein 1

decreases expression

3-methyladenine results in decreased expression of KEAP1 protein

NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862

G

lysosomal-associated membrane protein 1

multiple interactions

3-methyladenine inhibits the reaction [Doxorubicin results in decreased expression of LAMP1 protein]
3-methyladenine inhibits the reaction [Arsenic Trioxide results in increased expression of LAMP1 mRNA]; 3-methyladenine inhibits the reaction [Arsenic Trioxide results in increased expression of LAMP1 protein]

PMID:31226464 PMID:33462182

NCBI chr16:76,355,982...76,380,700
Ensembl chr16:76,355,984...76,381,883

G

lysosomal-associated membrane protein 2

multiple interactions

3-methyladenine inhibits the reaction [Doxorubicin results in decreased expression of LAMP2 protein]

NCBI chr X:117,173,097...117,222,090
Ensembl chr X:117,057,606...117,260,522

G

lactate dehydrogenase A

multiple interactions
decreases expression

3-methyladenine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of LDHA protein]; 3-methyladenine inhibits the reaction [Potassium Dichromate results in increased expression of LDHA protein]; 4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine inhibits the reaction [3-methyladenine results in decreased expression of LDHA protein]
3-methyladenine inhibits the reaction [Ethanol results in increased secretion of LDHA protein]

PMID:32569804 PMID:34481905 PMID:36336208 PMID:37898230

NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472

G

galectin 1

multiple interactions

3-methyladenine inhibits the reaction [LGALS1 protein results in decreased expression of SQSTM1 protein]; 3-methyladenine inhibits the reaction [LGALS1 protein results in decreased susceptibility to Cisplatin]; 3-methyladenine inhibits the reaction [LGALS1 protein results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [LGALS1 protein results in increased expression of MAP1LC3B protein modified form]

NCBI chr 7:110,485,239...110,488,345
Ensembl chr 7:110,481,392...110,488,345

G

leucine-rich repeat kinase 2

multiple interactions

3-methyladenine inhibits the reaction [LRRK2 gene mutant form results in increased susceptibility to 1-Methyl-4-phenylpyridinium]

NCBI chr 7:122,826,696...122,987,711
Ensembl chr 7:122,826,696...122,987,703

G

microtubule-associated protein 1 light chain 3 alpha

multiple interactions
affects metabolic processing

3-methyladenine inhibits the reaction [sodium arsenite results in increased expression of MAP1LC3A protein modified form]
3-methyladenine inhibits the reaction [alisol A 24-acetate results in increased expression of MAP1LC3A protein]; 3-methyladenine inhibits the reaction [alisol B 23-acetate results in increased expression of MAP1LC3A protein]
3-methyladenine affects the metabolism of MAP1LC3A protein

PMID:20008137 PMID:21742779 PMID:28408883

NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670

G

microtubule-associated protein 1 light chain 3 beta

multiple interactions
increases expression
increases lipidation
decreases expression
decreases cleavage
affects metabolic processing

3-methyladenine affects the reaction [Alpha-Amanitin affects the lipidation of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [2,4,4'-trichlorobiphenyl results in increased cleavage of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [2,5,2',5'-tetrachlorobiphenyl results in increased cleavage of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [[alpha-Chlorohydrin co-treated with Diosgenin] results in increased lipidation of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [[TNF protein co-treated with Resveratrol] results in increased expression of MAP1LC3B protein alternative form]; 3-methyladenine inhibits the reaction [ABBV-744 results in increased expression of and results in increased lipidation of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [Arsenic Trioxide results in increased cleavage of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [Artesunate results in increased lipidation of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [beta-ionone results in increased expression of and results in increased lipidation of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [Cadmium Chloride results in increased expression of MAP1LC3B protein modified form]; 3-methyladenine inhibits the reaction [Caffeine results in increased cleavage of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [Curcumin results in increased lipidation of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [di-n-propyldithiocarbamate results in increased expression of and results in increased lipidation of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [dimethyl alpha-ketoglutarate results in increased lipidation of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [E platinum results in increased expression of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [E platinum results in increased metabolism of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [flavokawain B results in increased expression of MAP1LC3B protein modified form]; 3-methyladenine inhibits the reaction [Hydrogen Peroxide results in increased expression of MAP1LC3B mRNA]; 3-methyladenine inhibits the reaction [Hydrogen Peroxide results in increased expression of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [Ivermectin results in increased expression of and results in increased lipidation of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [LGALS1 protein results in increased expression of MAP1LC3B protein modified form]; 3-methyladenine inhibits the reaction [ovatodiolide results in increased lipidation of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [Particulate Matter results in increased expression of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [Quercetin results in increased cleavage of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [SC-66 compound results in increased lipidation of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [sepantronium results in increased lipidation of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [Sevoflurane results in increased lipidation of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [Vorinostat results in increased expression of MAP1LC3B protein modified form]; 3-methyladenine results in increased expression of and results in increased lipidation of MAP1LC3B protein; [3-methyladenine co-treated with TNF protein] results in decreased expression of MAP1LC3B protein alternative form; [bisphenol A co-treated with 3-methyladenine] results in increased lipidation of MAP1LC3B protein; Cadmium Chloride promotes the reaction [3-methyladenine results in increased expression of MAP1LC3B protein modified form]
3-methyladenine results in increased lipidation of MAP1LC3B protein
3-methyladenine results in decreased expression of MAP1LC3B mRNA
3-methyladenine results in decreased cleavage of MAP1LC3B protein
3-methyladenine affects the metabolism of MAP1LC3B protein
3-methyladenine inhibits the reaction [2,4,4'-trichlorobiphenyl results in increased cleavage of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [2,5,2',5'-tetrachlorobiphenyl results in increased cleavage of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [Dibutyl Phthalate results in increased cleavage of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [erastin results in increased expression of MAP1LC3B protein modified form]; 3-methyladenine inhibits the reaction [N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide inhibits the reaction [Glucose results in decreased expression of MAP1LC3B protein]]; 3-methyladenine inhibits the reaction [osthol inhibits the reaction [Antineoplastic Agents, Immunological results in decreased lipidation of MAP1LC3B protein]]; 3-methyladenine inhibits the reaction [Sirolimus results in increased expression of MAP1LC3B protein modified form]; 3-methyladenine results in decreased expression of and results in decreased cleavage of MAP1LC3B protein
3-methyladenine results in decreased expression of MAP1LC3B mRNA; 3-methyladenine results in decreased expression of MAP1LC3B protein modified form
3-methyladenine affects the reaction [T-2 Toxin affects the expression of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [Busulfan results in increased expression of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [Cadmium Chloride results in increased expression of MAP1LC3B protein alternative form]; 3-methyladenine inhibits the reaction [Caffeine results in increased cleavage of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [dibromoacetonitrile results in increased expression of and results in increased localization of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [Dibutyl Phthalate results in increased cleavage of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [Ethanol results in increased lipidation of MAP1LC3B protein]; cupric chloride inhibits the reaction [3-methyladenine results in decreased expression of MAP1LC3B protein modified form]

PMID:18640276 PMID:20962572 PMID:21325019 PMID:21681844 PMID:22322152 More...

NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690

G

microtubule-associated protein 2

multiple interactions

3-methyladenine inhibits the reaction [Sirolimus results in increased expression of MAP2 protein]

NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809

G

mitogen-activated protein kinase kinase kinase 5

affects response to substance
multiple interactions

3-methyladenine affects the susceptibility to MAP3K5 protein
3-methyladenine inhibits the reaction [MAP3K5 protein results in decreased phosphorylation of MTOR protein]; 3-methyladenine promotes the reaction [MAP3K5 protein affects the localization of CYCS protein]; 3-methyladenine promotes the reaction [MAP3K5 protein results in increased activity of CASP3 protein]

NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800

G

mitogen activated protein kinase 1

increases expression
increases phosphorylation
multiple interactions

3-methyladenine results in increased expression of MAPK1 protein modified form
3-methyladenine results in increased phosphorylation of MAPK1 protein
3-methyladenine inhibits the reaction [Iron Compounds results in increased expression of MAPK1 protein modified form]; Cadmium Chloride promotes the reaction [3-methyladenine results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [3-methyladenine results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Cadmium Chloride promotes the reaction [3-methyladenine results in increased phosphorylation of MAPK1 protein]]

PMID:28483490 PMID:34580807

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

increases expression
increases phosphorylation
multiple interactions

3-methyladenine results in increased expression of MAPK3 protein modified form
3-methyladenine results in increased phosphorylation of MAPK3 protein
3-methyladenine inhibits the reaction [Iron Compounds results in increased expression of MAPK3 protein modified form]; Cadmium Chloride promotes the reaction [3-methyladenine results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [3-methyladenine results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Cadmium Chloride promotes the reaction [3-methyladenine results in increased phosphorylation of MAPK3 protein]]

PMID:28483490 PMID:34580807

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

MCL1 apoptosis regulator, BCL2 family member

multiple interactions

3-methyladenine inhibits the reaction [sepantronium results in decreased expression of MCL1 protein]; 3-methyladenine promotes the reaction [usnic acid results in decreased expression of MCL1 protein]

PMID:25078063 PMID:31837377

NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303

G

mixed lineage kinase domain like pseudokinase

multiple interactions

3-methyladenine inhibits the reaction [Ethanol results in increased expression of and results in increased phosphorylation of MLKL protein]

NCBI chr19:39,277,526...39,304,555
Ensembl chr19:39,276,785...39,304,502

G

matrix metallopeptidase 2

multiple interactions

3-methyladenine inhibits the reaction [Lactic Acid promotes the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MMP2 protein]]

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 9

multiple interactions

3-methyladenine inhibits the reaction [Hydrogen Peroxide results in decreased expression of MMP9 protein]; 3-methyladenine inhibits the reaction [Lactic Acid promotes the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MMP9 protein]]; 3-methyladenine inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]

PMID:24145604 PMID:32043704 PMID:36336208

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

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N-methylpurine-DNA glycosylase

increases metabolic processing

MPG protein results in increased metabolism of 3-methyladenine

NCBI chr10:15,396,246...15,402,528
Ensembl chr10:15,395,782...15,402,520

G

myeloperoxidase

multiple interactions

3-methyladenine inhibits the reaction [lead acetate results in increased expression of MPO protein]

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

mitochondrially encoded cytochrome c oxidase II

multiple interactions

3-methyladenine inhibits the reaction [Curcumin results in decreased expression of COX2 protein]

NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689

G

mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1

multiple interactions

3-methyladenine inhibits the reaction [HMGA2 protein results in decreased expression of ND1 protein]

NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
Ensembl chr MT:2,740...3,694

G

mechanistic target of rapamycin kinase

multiple interactions
decreases expression
increases phosphorylation
increases expression
decreases phosphorylation

3-methyladenine inhibits the reaction [2,4,4'-trichlorobiphenyl results in increased expression of MTOR protein]; 3-methyladenine inhibits the reaction [2,5,2',5'-tetrachlorobiphenyl results in increased expression of MTOR protein]; 3-methyladenine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MTOR protein]; 3-methyladenine inhibits the reaction [Cisplatin results in decreased phosphorylation of MTOR protein]; 3-methyladenine inhibits the reaction [dimethyl alpha-ketoglutarate results in decreased phosphorylation of MTOR protein]; 3-methyladenine inhibits the reaction [Diosgenin promotes the reaction [alpha-Chlorohydrin results in decreased phosphorylation of MTOR protein]]; 3-methyladenine inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of MTOR protein]; 3-methyladenine inhibits the reaction [MAP3K5 protein results in decreased phosphorylation of MTOR protein]; 3-methyladenine results in decreased expression of and results in decreased phosphorylation of MTOR protein; 4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine inhibits the reaction [3-methyladenine results in decreased expression of MTOR protein]
3-methyladenine results in increased phosphorylation of MTOR protein
3-methyladenine inhibits the reaction [Arsenic Trioxide results in decreased phosphorylation of MTOR protein]
3-methyladenine results in increased expression of MTOR protein
3-methyladenine results in decreased phosphorylation of MTOR protein

PMID:20929985 PMID:26804764 PMID:29518472 PMID:32043704 PMID:33462182 More...

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

G

Nanog homeobox

increases expression

3-methyladenine results in increased expression of NANOG mRNA

NCBI chr 4:155,943,737...155,951,116
Ensembl chr 4:155,943,737...155,951,116

G

nuclear receptor coactivator 4

multiple interactions

3-methyladenine inhibits the reaction [di-n-propyldithiocarbamate results in increased expression of NCOA4 protein]
3-methyladenine inhibits the reaction [Busulfan results in increased expression of NCOA4 protein]
3-methyladenine inhibits the reaction [erastin results in decreased expression of NCOA4 protein]

PMID:32687844 PMID:32937103 PMID:38220133

NCBI chr16:7,389,222...7,409,564
Ensembl chr16:7,366,542...7,409,641
Ensembl chr16:7,366,542...7,409,641

G

NADH:ubiquinone oxidoreductase subunit A1

multiple interactions

[3-methyladenine co-treated with Taurine] inhibits the reaction [1-nitropyrene results in decreased expression of NDUFA1 mRNA]
[Taurine co-treated with 3-methyladenine] inhibits the reaction [1-nitropyrene results in decreased expression of NDUFA1 mRNA]

NCBI chr X:116,424,223...116,427,875
Ensembl chr X:116,424,223...116,428,633

G

NADH:ubiquinone oxidoreductase subunit A2

multiple interactions

[3-methyladenine co-treated with Taurine] inhibits the reaction [1-nitropyrene results in decreased expression of NDUFA2 mRNA]
3-methyladenine inhibits the reaction [1-nitropyrene results in decreased expression of NDUFA2 mRNA]; Taurine promotes the reaction [3-methyladenine inhibits the reaction [1-nitropyrene results in decreased expression of NDUFA2 mRNA]]

NCBI chr18:28,355,774...28,357,863
Ensembl chr18:28,355,774...28,358,076

G

NADH:ubiquinone oxidoreductase subunit C2

multiple interactions

[3-methyladenine co-treated with Taurine] inhibits the reaction [1-nitropyrene results in decreased expression of NDUFC2 mRNA]

NCBI chr 1:151,711,965...151,718,188
Ensembl chr 1:151,711,901...151,718,189

G

NADH:ubiquinone oxidoreductase core subunit S3

multiple interactions

3-methyladenine inhibits the reaction [Chlorpyrifos results in decreased expression of NDUFS3 protein]

NCBI chr 3:76,876,646...76,883,824
Ensembl chr 3:76,876,646...76,883,824

G

NADH:ubiquinone oxidoreductase subunit S4

multiple interactions

[3-methyladenine co-treated with Taurine] inhibits the reaction [1-nitropyrene results in decreased expression of NDUFS4 mRNA]

NCBI chr 2:45,951,327...46,061,829
Ensembl chr 2:45,951,313...46,061,846

G

neurofilament heavy chain

multiple interactions

3-methyladenine inhibits the reaction [tri-o-cresyl phosphate results in decreased expression of NEFH protein]

NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351

G

neurofilament light chain

multiple interactions

3-methyladenine inhibits the reaction [tri-o-cresyl phosphate results in decreased expression of NEFL protein]

NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793

G

NLR family, pyrin domain containing 3

multiple interactions

3-methyladenine inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Cisplatin results in increased expression of NLRP3 protein]]; 3-methyladenine inhibits the reaction [Patulin results in increased expression of NLRP3 protein]; 3-methyladenine promotes the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased expression of NLRP3 protein]; 3-methyladenine promotes the reaction [Acrolein results in increased expression of NLRP3 protein]
3-methyladenine inhibits the reaction [sphingosine 1-phosphate results in increased expression of NLRP3 protein]

PMID:30205151 PMID:33217525 PMID:34238121 PMID:34423507 PMID:37169277

NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811

G

notch receptor 2

multiple interactions

3-methyladenine inhibits the reaction [Dibutyl Phthalate results in decreased expression of NOTCH2 protein alternative form]

NCBI chr 2:185,610,594...185,744,088
Ensembl chr 2:185,610,589...185,744,088

G

natriuretic peptide B

multiple interactions

3-methyladenine inhibits the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of NPPB mRNA]]; 3-methyladenine inhibits the reaction [Mirtazapine results in increased expression of NPPB mRNA]

NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168

G

poly (ADP-ribose) polymerase 1

multiple interactions
increases cleavage

3-methyladenine promotes the reaction [Fluorouracil results in increased cleavage of and results in increased activity of PARP1 protein]
3-methyladenine inhibits the reaction [aristolochic acid I results in increased cleavage of PARP1 protein]; 3-methyladenine promotes the reaction [Methamphetamine results in increased cleavage of PARP1 protein]
3-methyladenine inhibits the reaction [3,7-dioxolanosta-8,24-dien-26-oic acid results in increased cleavage of PARP1 protein]; 3-methyladenine inhibits the reaction [Artesunate results in increased cleavage of PARP1 protein]; 3-methyladenine inhibits the reaction [beta-ionone results in increased cleavage of PARP1 protein]; 3-methyladenine inhibits the reaction [divinyl sulfone analog results in increased cleavage of PARP1 protein]; 3-methyladenine inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein]; 3-methyladenine inhibits the reaction [Morpholines analog results in increased cleavage of PARP1 protein]; 3-methyladenine inhibits the reaction [Oligopeptides analog results in increased cleavage of PARP1 protein]; 3-methyladenine inhibits the reaction [ovatodiolide results in increased cleavage of PARP1 protein]; 3-methyladenine inhibits the reaction [polyphyllin I results in increased expression of PARP1 protein modified form]; 3-methyladenine inhibits the reaction [Resveratrol inhibits the reaction [Rotenone results in increased cleavage of PARP1 protein]]; 3-methyladenine promotes the reaction [BO-1012 results in increased cleavage of PARP1 protein]; 3-methyladenine promotes the reaction [embelin results in increased cleavage of PARP1 protein]; 3-methyladenine promotes the reaction [Flavanones results in increased cleavage of PARP1 protein]; 3-methyladenine promotes the reaction [Fluorouracil results in increased cleavage of and results in increased activity of PARP1 protein]; 3-methyladenine promotes the reaction [fosbretabulin results in increased cleavage of PARP1 protein]; 3-methyladenine promotes the reaction [SC-66 compound results in increased cleavage of PARP1 protein]; 3-methyladenine promotes the reaction [Silybin results in increased cleavage of PARP1 protein]; [3-methyladenine co-treated with Amiodarone] results in increased cleavage of PARP1 protein; [3-methyladenine co-treated with fosbretabulin] results in increased cleavage of PARP1 protein; [Chloroquine co-treated with 3-methyladenine] results in increased cleavage of PARP1 protein; [flavokawain B co-treated with 3-methyladenine] results in increased cleavage of PARP1 protein
3-methyladenine results in increased cleavage of PARP1 protein

PMID:19116755 PMID:21616090 PMID:21778691 PMID:23912912 PMID:23939141 More...

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

phosphatidylinositol 3-kinase, catalytic subunit type 3

multiple interactions

3-methyladenine inhibits the reaction [gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human promotes the reaction [BECN1 protein binds to PIK3C3 protein]]]; 3-methyladenine inhibits the reaction [gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of PIK3C3 protein]]; 3-methyladenine inhibits the reaction [Hydrogen Peroxide promotes the reaction [BECN1 protein binds to PIK3C3 protein]]; 3-methyladenine inhibits the reaction [malondialdehyde-low density lipoprotein, human promotes the reaction [BECN1 protein binds to PIK3C3 protein]]; 3-methyladenine inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of PIK3C3 protein]; 3-methyladenine inhibits the reaction [Silicon Dioxide promotes the reaction [PIK3C3 protein binds to BECN1 protein]]; [3-methyladenine results in decreased activity of PIK3C3 protein] which results in decreased susceptibility to Hydrogen Peroxide
3-methyladenine inhibits the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of PIK3C3 protein]]; 3-methyladenine inhibits the reaction [Mirtazapine results in increased expression of PIK3C3 protein]

PMID:20525898 PMID:21742779 PMID:25622137 PMID:32061152 PMID:35066094

NCBI chr18:21,845,282...21,934,387
Ensembl chr18:21,845,295...21,929,048

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phosphoinositide-3-kinase regulatory subunit 1

multiple interactions

3-methyladenine inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of PIK3R1 protein]

NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631

G

pyruvate kinase M1/2

multiple interactions

3-methyladenine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PKM protein]; 3-methyladenine inhibits the reaction [Potassium Dichromate results in increased expression of PKM protein]

PMID:32569804 PMID:34481905 PMID:36336208

NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599

G

PML nuclear body scaffold

multiple interactions

3-methyladenine inhibits the reaction [4-amino-2-trifluoromethyl-phenyl retinate results in increased degradation of [PML protein mutant form binds to RARA protein mutant form]]

NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971

G

POU class 5 homeobox 1

increases expression

3-methyladenine results in increased expression of POU5F1 protein

NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891

G

peroxisome proliferator activated receptor alpha

multiple interactions

3-methyladenine inhibits the reaction [Arsenic Trioxide results in increased expression of PPARA protein]

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

G

prostaglandin-endoperoxide synthase 2

multiple interactions

3-methyladenine inhibits the reaction [resveratrol inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]]

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

PYD and CARD domain containing

multiple interactions

3-methyladenine inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Cisplatin results in increased expression of PYCARD protein]]

NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955

G

retinoic acid receptor, alpha

multiple interactions

3-methyladenine inhibits the reaction [4-amino-2-trifluoromethyl-phenyl retinate results in increased degradation of [PML protein mutant form binds to RARA protein mutant form]]

NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

3-methyladenine inhibits the reaction [Particulate Matter results in increased expression of RELA protein modified form]; 3-methyladenine inhibits the reaction [Particulate Matter results in increased expression of RELA protein]
3-methyladenine promotes the reaction [Zearalenone results in increased phosphorylation of and affects the localization of RELA protein]

PMID:28867211 PMID:31586597

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

receptor interacting serine/threonine kinase 1

multiple interactions

3-methyladenine inhibits the reaction [Ethanol results in increased expression of RIPK1 protein]

NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824

G

receptor-interacting serine-threonine kinase 3

multiple interactions

3-methyladenine inhibits the reaction [Ethanol results in increased expression of RIPK3 protein]

NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121

G

ribosomal protein S6 kinase B1

decreases phosphorylation
increases phosphorylation
multiple interactions

3-methyladenine results in decreased phosphorylation of RPS6KB1 protein
3-methyladenine results in increased phosphorylation of RPS6KB1 protein
3-methyladenine inhibits the reaction [[Diosgenin co-treated with alpha-Chlorohydrin] results in decreased phosphorylation of RPS6KB1 protein]

PMID:26804764 PMID:35149085

NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908

G

RUNX family transcription factor 2

multiple interactions

3-methyladenine promotes the reaction [T-2 Toxin results in decreased expression of RUNX2 protein]

NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167

G

solute carrier family 16 member 1

multiple interactions

3-methyladenine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SLC16A1 protein]

NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611

G

solute carrier family 2 member 1

multiple interactions
decreases expression

3-methyladenine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SLC2A1 protein]; 3-methyladenine inhibits the reaction [Potassium Dichromate results in increased expression of SLC2A1 protein]; 3-methyladenine promotes the reaction [Silybin results in decreased expression of SLC2A1 protein]; 4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine inhibits the reaction [3-methyladenine results in decreased expression of SLC2A1 protein]

PMID:32569804 PMID:34053323 PMID:34481905 PMID:36336208

NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416

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solute carrier family 2 member 4

multiple interactions

3-methyladenine promotes the reaction [Silybin results in decreased expression of SLC2A4 protein]

NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565

G

solute carrier family 7 member 11

multiple interactions

3-methyladenine inhibits the reaction [Busulfan results in decreased expression of SLC7A11 protein]

NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536

G

synuclein alpha

multiple interactions

3-methyladenine inhibits the reaction [Rotenone results in decreased expression of SNCA mRNA]; 3-methyladenine inhibits the reaction [Rotenone results in decreased expression of SNCA protein]

NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262

G

SRY-box transcription factor 2

increases expression

3-methyladenine results in increased expression of SOX2 mRNA

NCBI chr 2:117,536,929...117,539,340
Ensembl chr 2:117,536,929...117,539,338

G

Sp7 transcription factor

multiple interactions

3-methyladenine promotes the reaction [T-2 Toxin results in decreased expression of SP7 protein]

NCBI chr 7:133,484,609...133,494,788
Ensembl chr 7:133,484,609...133,494,847

G

sequestosome 1

increases expression
multiple interactions

3-methyladenine results in increased expression of SQSTM1 protein
3-methyladenine inhibits the reaction [anemoside B4 inhibits the reaction [Lipopolysaccharides results in increased expression of SQSTM1 protein]]; 3-methyladenine inhibits the reaction [Arsenic Trioxide results in decreased expression of SQSTM1 protein]; 3-methyladenine inhibits the reaction [Busulfan results in decreased expression of SQSTM1 protein]; 3-methyladenine inhibits the reaction [Ethanol results in decreased expression of SQSTM1 protein]
3-methyladenine inhibits the reaction [2,4,4'-trichlorobiphenyl results in increased expression of SQSTM1 protein]; 3-methyladenine inhibits the reaction [2,5,2',5'-tetrachlorobiphenyl results in increased expression of SQSTM1 protein]; 3-methyladenine inhibits the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of SQSTM1 protein]]; 3-methyladenine inhibits the reaction [fenvalerate results in decreased expression of SQSTM1 protein]; 3-methyladenine inhibits the reaction [Mirtazapine results in increased expression of SQSTM1 protein]; 3-methyladenine inhibits the reaction [N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide inhibits the reaction [Glucose results in increased expression of SQSTM1 protein]]; 3-methyladenine inhibits the reaction [osthol inhibits the reaction [Antineoplastic Agents, Immunological results in increased expression of SQSTM1 protein]]
3-methyladenine affects the reaction [ginsenoside Rg3 affects the reaction [Cisplatin affects the expression of SQSTM1 protein]]; 3-methyladenine inhibits the reaction [2,4,4'-trichlorobiphenyl results in increased expression of SQSTM1 protein]; 3-methyladenine inhibits the reaction [2,5,2',5'-tetrachlorobiphenyl results in increased expression of SQSTM1 protein]; 3-methyladenine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SQSTM1 protein]; 3-methyladenine inhibits the reaction [ABBV-744 results in decreased expression of SQSTM1 protein]; 3-methyladenine inhibits the reaction [Arsenic Trioxide results in decreased expression of SQSTM1 protein]; 3-methyladenine inhibits the reaction [Cisplatin results in decreased expression of SQSTM1 protein]; 3-methyladenine inhibits the reaction [Doxorubicin results in increased degradation of SQSTM1 protein]; 3-methyladenine inhibits the reaction [Ivermectin results in decreased expression of SQSTM1 protein]; 3-methyladenine inhibits the reaction [LGALS1 protein results in decreased expression of SQSTM1 protein]; 3-methyladenine inhibits the reaction [Particulate Matter results in increased expression of SQSTM1 protein]; 3-methyladenine inhibits the reaction [Potassium Dichromate results in decreased expression of SQSTM1 protein]; 3-methyladenine inhibits the reaction [Potassium Iodide results in increased expression of SQSTM1 mRNA]; 3-methyladenine inhibits the reaction [Potassium Iodide results in increased expression of SQSTM1 protein]; 3-methyladenine inhibits the reaction [Quercetin results in decreased expression of SQSTM1 protein]; 3-methyladenine inhibits the reaction [Resveratrol results in increased degradation of SQSTM1 protein]; 3-methyladenine inhibits the reaction [sepantronium results in decreased expression of SQSTM1 protein]; 3-methyladenine inhibits the reaction [Silicon Dioxide results in decreased expression of SQSTM1 protein]; 3-methyladenine inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased degradation of SQSTM1 protein]; 3-methyladenine promotes the reaction [alpha-Chlorohydrin results in increased expression of SQSTM1 protein]; 3-methyladenine promotes the reaction [ovatodiolide results in increased expression of SQSTM1 protein]; [3-methyladenine co-treated with bisphenol A] results in increased expression of SQSTM1 protein; Ropivacaine inhibits the reaction [3-methyladenine results in increased expression of SQSTM1 protein]

PMID:20574048 PMID:22927544 PMID:24833599 PMID:25943029 PMID:28025121 More...

NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673

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tyrosine hydroxylase

multiple interactions

3-methyladenine inhibits the reaction [fenvalerate results in decreased expression of TH protein]; 3-methyladenine inhibits the reaction [Oxidopamine results in decreased expression of TH protein]

PMID:28802652 PMID:31734597

NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767

G

tumor necrosis factor

multiple interactions
increases expression

3-methyladenine inhibits the reaction [[TNF protein co-treated with Resveratrol] results in increased expression of MAP1LC3B protein alternative form]; 3-methyladenine inhibits the reaction [Particulate Matter results in increased secretion of TNF protein]; 3-methyladenine inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; 3-methyladenine inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]; 3-methyladenine inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]]; [3-methyladenine co-treated with TNF protein] results in decreased expression of MAP1LC3B protein alternative form
3-methyladenine inhibits the reaction [anemoside B4 inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]
3-methyladenine results in increased expression of TNF mRNA
3-methyladenine inhibits the reaction [lead acetate results in increased expression of TNF protein]; 3-methyladenine promotes the reaction [[Zearalenone co-treated with Lipopolysaccharides] results in increased expression of TNF protein]

PMID:24145604 PMID:29781141 PMID:31513885 PMID:31586597 PMID:32879255 More...

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

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troponin T2, cardiac type

multiple interactions

3-methyladenine inhibits the reaction [citreoviridin results in increased secretion of TNNT2 protein]

NCBI chr13:47,267,325...47,285,390
Ensembl chr13:47,267,204...47,285,388

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translocase of outer mitochondrial membrane 20

multiple interactions

3-methyladenine inhibits the reaction [Doxorubicin results in decreased expression of TOMM20 protein]

NCBI chr19:54,925,197...54,935,188
Ensembl chr19:54,923,402...54,935,198

G

tumor protein p53

multiple interactions

3-methyladenine inhibits the reaction [[cobaltous chloride co-treated with TP53 gene mutant form] results in increased activity of CTSB protein]; 3-methyladenine inhibits the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased phosphorylation of TP53 protein]]; 3-methyladenine inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]; [3-methyladenine co-treated with cobaltous chloride co-treated with TP53 gene mutant form] results in increased activity of CASP3 protein
3-methyladenine inhibits the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased phosphorylation of TRP53 protein]]

PMID:22927544 PMID:23380477 PMID:30555576

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

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tumor protein p53 binding protein, 2

multiple interactions

TRP53BP2 protein affects the reaction [3-methyladenine results in increased expression of GPT protein]; TRP53BP2 protein affects the reaction [3-methyladenine results in increased expression of IL1B mRNA]; TRP53BP2 protein affects the reaction [3-methyladenine results in increased expression of IL6 mRNA]

NCBI chr13:94,088,769...94,145,436
Ensembl chr13:94,088,709...94,145,432

G

unc-51 like autophagy activating kinase 1

multiple interactions
decreases expression
increases phosphorylation

3-methyladenine affects the reaction [N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide affects the reaction [Glucose affects the phosphorylation of ULK1 protein]]; 3-methyladenine inhibits the reaction [2,4,4'-trichlorobiphenyl results in increased expression of ULK1 protein]; 3-methyladenine inhibits the reaction [2,5,2',5'-tetrachlorobiphenyl results in increased expression of ULK1 protein]
3-methyladenine results in decreased expression of ULK1 protein
3-methyladenine results in increased phosphorylation of ULK1 protein
3-methyladenine inhibits the reaction [2,4,4'-trichlorobiphenyl results in increased expression of ULK1 protein]; 3-methyladenine inhibits the reaction [[Diosgenin co-treated with alpha-Chlorohydrin] results in decreased phosphorylation of ULK1 protein]; Alpha-Amanitin inhibits the reaction [3-methyladenine results in decreased expression of ULK1 protein]

PMID:29128638 PMID:29518472 PMID:35149085 PMID:37329965

NCBI chr12:45,851,710...45,877,966
Ensembl chr12:45,851,710...45,877,966

G

Wnt family member 3A

multiple interactions

3-methyladenine promotes the reaction [T-2 Toxin results in decreased expression of WNT3A protein]

NCBI chr10:44,034,174...44,078,366
Ensembl chr10:44,034,194...44,078,324

5'-S-methyl-5'-thioadenosine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

actin alpha 2, smooth muscle

decreases expression

5'-S-methyl-5'-thioadenosine decreases expression of Acta2 mRNA in Mdr2-/- mouse liver and liver myofibroblasts

RGD

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

adenosine A2B receptor

multiple interactions

5'-S-methyl-5'-thioadenosine enhances the reaction [lipopolysaccharide increases expression of Adora2b mRNA in mouse liver myofibroblasts]

RGD

NCBI chr10:46,940,394...46,956,772
Ensembl chr10:46,940,384...46,956,772

G

AKT serine/threonine kinase 1

decreases phosphorylation
multiple interactions

5'-methylthioadenosine results in decreased phosphorylation of AKT1 protein
IL7 protein inhibits the reaction [5'-methylthioadenosine results in decreased phosphorylation of AKT1 protein]

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

C-C motif chemokine ligand 2

decreases expression

5'-S-methyl-5'-thioadenosine decreases expression of Ccl2 mRNA in Mdr2-/- mouse liver and myofibroblasts

RGD

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

cyclin D1

decreases expression

5'-S-methyl-5'-thioadenosine decreases expression of cyclin-D1 mRNA in Mdr2-/- mouse liver myofibroblasts

RGD

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

collagen type I alpha 1 chain

decreases expression

5'-methylthioadenosine results in decreased expression of COL1A1 mRNA
5'-S-methyl-5'-thioadenosine decreases expression of Col1a1 mRNA in Mdr2-/- mouse liver and liver myofibroblasts

CTD
RGD

PMID:15983038 PMID:21209952

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

collagen type I alpha 2 chain

decreases expression

5'-methylthioadenosine results in decreased expression of COL1A2 mRNA

NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867

G

isocitrate dehydrogenase (NADP(+)) 2

increases abundance
multiple interactions

IDH2 protein mutant form results in increased abundance of 5'-methylthioadenosine
Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of 5'-methylthioadenosine]

NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025

G

interferon gamma

multiple interactions
decreases secretion

5'-methylthioadenosine inhibits the reaction [fumonisin B1 results in increased expression of IFNG mRNA]
5'-methylthioadenosine results in decreased secretion of IFNG protein

PMID:17080400 PMID:31712395

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

interferon, lambda 1

multiple interactions

5'-methylthioadenosine inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of IFNL1 mRNA]

NCBI chr 1:83,798,651...83,800,297
Ensembl chr 1:83,798,703...83,800,235

G

interleukin 1 beta

multiple interactions

5'-methylthioadenosine inhibits the reaction [fumonisin B1 results in increased expression of IL1B mRNA]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 2

multiple interactions
decreases secretion

5'-methylthioadenosine inhibits the reaction [fumonisin B1 results in increased expression of IL2 mRNA]
5'-methylthioadenosine results in decreased secretion of IL2 protein

PMID:17080400 PMID:31712395

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 33

multiple interactions

5'-methylthioadenosine inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of IL33 mRNA]

NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373

G

interleukin 6

multiple interactions
decreases expression

5'-methylthioadenosine inhibits the reaction [fumonisin B1 results in increased expression of IL6 mRNA]
5'-S-methyl-5'-thioadenosine decreases expression of Il6 mRNA in Mdr2-/- mouse liver

CTD
RGD

PMID:17080400 PMID:21209952

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

interleukin 7

multiple interactions

IL7 protein inhibits the reaction [5'-methylthioadenosine results in decreased phosphorylation of AKT1 protein]

NCBI chr 2:94,235,219...94,280,075
Ensembl chr 2:94,234,766...94,280,075

G

JunD proto-oncogene, AP-1 transcription factor subunit

decreases expression

5'-S-methyl-5'-thioadenosine decreases expression of JunD protein in Mdr2-/- mouse liver myofibroblasts

RGD

NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799

G

lymphotoxin beta

multiple interactions

5'-methylthioadenosine inhibits the reaction [fumonisin B1 results in increased expression of LTB mRNA]

NCBI chr20:3,627,536...3,629,381
Ensembl chr20:3,627,537...3,629,381

G

MDM4 regulator of p53

multiple interactions

5'-methylthioadenosine affects the splicing of and affects the expression of MDM4 mRNA alternative form

NCBI chr13:44,432,596...44,516,165
Ensembl chr13:44,406,213...44,474,226

G

marker of proliferation Ki-67

decreases expression

5'-S-methyl-5'-thioadenosine decreases expression of Ki-67 protein in Mdr2-/- mouse liver

RGD

NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762

G

matrix metallopeptidase 13

decreases expression

5'-S-methyl-5'-thioadenosine decreases expression of MMP13 mRNA in Mdr2-/- mouse liver

RGD

NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239

G

mechanistic target of rapamycin kinase

decreases phosphorylation

5'-methylthioadenosine results in decreased phosphorylation of MTOR protein

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

G

nitric oxide synthase 2

decreases expression

5'-S-methyl-5'-thioadenosine decreases expression of iNOS mRNA in Mdr2-/- mouse liver

RGD

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

ribosomal protein S6

decreases phosphorylation

5'-methylthioadenosine results in decreased phosphorylation of RPS6 protein

NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602

G

transforming growth factor, beta 1

decreases expression

5'-S-methyl-5'-thioadenosine decreases expression of Tgfb1 mRNA in Mdr2-/- mouse liver myofibroblasts

RGD

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

transforming growth factor, beta 2

decreases expression

5'-S-methyl-5'-thioadenosine decreases expression of Tgfb2 mRNA in Mdr2-/- mouse liver and myofibroblasts

RGD

NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405

G

tenascin C

decreases expression

5'-S-methyl-5'-thioadenosine decreases expression of tenascin-C mRNA in Mdr2-/- mouse liver

RGD

NCBI chr 5:77,375,851...77,460,712
Ensembl chr 5:77,375,851...77,460,624

G

tumor necrosis factor

multiple interactions

5'-S-methyl-5'-thioadenosine inhibits the reaction [lipopolysaccharide increases expression of Tnf-alpha mRNA and protein in mouse liver myofibroblasts]

RGD

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

tumor protein p53

increases expression

5'-methylthioadenosine results in increased expression of TP53 protein

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

9-(tetrahydrofuryl)adenine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

glucagon

multiple interactions

9-(tetrahydro-2-furyl)-adenine inhibits the reaction [geraniol results in increased secretion of GCG protein]

NCBI chr 3:47,113,914...47,122,958
Ensembl chr 3:47,113,914...47,122,929

G

patatin-like phospholipase domain containing 6

decreases expression

9-(tetrahydro-2-furyl)-adenine results in decreased expression of PNPLA6 mRNA; 9-(tetrahydro-2-furyl)-adenine results in decreased expression of PNPLA6 protein

NCBI chr12:1,574,387...1,603,735
Ensembl chr12:1,560,363...1,603,734

G

prostaglandin-endoperoxide synthase 2

multiple interactions

9-(tetrahydro-2-furyl)-adenine inhibits the reaction [methylmercuric chloride results in increased expression of PTGS2 protein]

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

acetoacetyl-CoA

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

hydroxysteroid (17-beta) dehydrogenase 2

affects binding

acetoacetyl CoA binds to HSD17B2 protein

NCBI chr19:45,753,576...45,825,203
Ensembl chr19:45,753,574...45,825,202

acetyl-CoA

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP citrate lyase

increases abundance
affects abundance

ACLY protein results in increased abundance of Acetyl Coenzyme A
ACLY protein affects the abundance of Acetyl Coenzyme A

PMID:28077572 PMID:36933457

NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320

G

amyloid beta precursor protein

affects localization
increases secretion
multiple interactions

APP protein affects the localization of Acetyl Coenzyme A
Acetyl Coenzyme A results in increased secretion of APP protein modified form
Acetyl Coenzyme A inhibits the reaction [Hydrogen Peroxide results in decreased secretion of APP protein modified form]
IL1B protein affects the reaction [APP protein affects the localization of Acetyl Coenzyme A]

PMID:16122837 PMID:22906069

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

carnitine O-acetyltransferase

decreases activity

Acetyl Coenzyme A deficiency results in decreased activity of CRAT protein

NCBI chr 3:13,675,684...13,689,282
Ensembl chr 3:13,675,684...13,689,255

G

ERCC excision repair 6, chromatin remodeling factor

decreases abundance
multiple interactions

ERCC6 gene mutant form results in decreased abundance of Acetyl Coenzyme A
3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in decreased abundance of Acetyl Coenzyme A]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [ERCC6 gene mutant form results in decreased abundance of Acetyl Coenzyme A]

NCBI chr16:7,764,983...7,835,587
Ensembl chr16:7,765,013...7,835,587

G

glucose-6-phosphatase catalytic subunit 1

multiple interactions

[Fluoxetine results in decreased expression of G6PC1 protein] which results in increased abundance of Acetyl Coenzyme A

NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804

G

interleukin 1 beta

multiple interactions

IL1B protein affects the reaction [APP protein affects the localization of Acetyl Coenzyme A]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

lysine acetyltransferase 2B

affects binding

Acetyl Coenzyme A binds to KAT2B protein

NCBI chr 9:6,562,525...6,667,064
Ensembl chr 9:6,562,288...6,667,064

G

meteorin-like, glial cell differentiation regulator

multiple interactions

METRNL protein inhibits the reaction [Dietary Fats results in decreased abundance of Acetyl Coenzyme A]

NCBI chr10:106,963,880...106,977,875
Ensembl chr10:106,963,880...106,977,869

G

N-acetyltransferase 1

multiple interactions
affects binding

[NQO1 protein co-treated with NADP co-treated with Acetyl Coenzyme A co-treated with NAT1 protein] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone; Acetyl Coenzyme A inhibits the reaction [Cyanamide results in decreased activity of NAT1 protein]; Acetyl Coenzyme A inhibits the reaction [Iodoacetamide results in decreased activity of NAT1 protein]
Acetyl Coenzyme A binds to NAT1 protein

PMID:20545351 PMID:22835378

NCBI chr16:22,218,217...22,238,516
Ensembl chr16:22,208,194...22,238,520

G

N-acetyltransferase 2

multiple interactions

[NAT2 protein co-treated with Acetyl Coenzyme A] promotes the reaction [[NQO1 protein co-treated with NADP] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone]; [NAT2 protein co-treated with Acetyl Coenzyme A] promotes the reaction [[SULT1A2 protein co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone]

NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520

G

NAD(P)H quinone dehydrogenase 1

multiple interactions

[NAT2 protein co-treated with Acetyl Coenzyme A] promotes the reaction [[NQO1 protein co-treated with NADP] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone]; [NQO1 protein co-treated with NADP co-treated with Acetyl Coenzyme A co-treated with NAT1 protein] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

acryloyl-CoA

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

enoyl-CoA hydratase, short chain 1

increases abundance

ECHS1 gene mutant form results in increased abundance of acryloyl-coenzyme A

NCBI chr 1:194,895,036...194,903,863
Ensembl chr 1:194,895,036...194,903,884

G

3-hydroxyisobutyryl-CoA hydrolase

increases abundance

HIBCH gene mutant form results in increased abundance of acryloyl-coenzyme A

NCBI chr 9:48,590,097...48,669,896
Ensembl chr 9:48,590,099...48,669,824

adefovir

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 4

multiple interactions
affects transport

Calcitriol promotes the reaction [ABCB4 protein affects the transport of adefovir]

PMID:21240898 PMID:21341280

NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202

G

ATP binding cassette subfamily C member 4

affects abundance
multiple interactions
decreases expression
increases export

ABCC4 protein affects the abundance of adefovir
[adefovir co-treated with Probenecid co-treated with Cromolyn Sodium] affects the expression of ABCC4 protein; [adefovir co-treated with Probenecid co-treated with Valsartan] affects the expression of ABCC4 protein; [adefovir co-treated with Probenecid] results in decreased expression of ABCC4 protein
adefovir results in decreased expression of ABCC4 protein
ABCC4 protein results in increased export of adefovir

PMID:18364470 PMID:35114312

NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283

G

actin alpha 2, smooth muscle

increases expression
multiple interactions

adefovir results in increased expression of ACTA2 protein
[adefovir co-treated with Probenecid] results in increased expression of ACTA2 protein; Cromolyn Sodium inhibits the reaction [[adefovir co-treated with Probenecid] results in increased expression of ACTA2 protein]; Valsartan inhibits the reaction [[adefovir co-treated with Probenecid] results in increased expression of ACTA2 protein]

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

angiotensinogen

multiple interactions

[Probenecid co-treated with adefovir] results in increased expression of AGT protein; [Probenecid co-treated with Valsartan co-treated with adefovir] results in increased expression of AGT protein; Cromolyn Sodium inhibits the reaction [[Probenecid co-treated with adefovir] results in increased expression of AGT protein]

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

beta-2 microglobulin

increases secretion

adefovir results in increased secretion of B2M protein

NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766

G

calbindin 1

increases secretion

adefovir results in increased secretion of CALB1 protein

NCBI chr 5:29,375,624...29,402,532
Ensembl chr 5:29,375,642...29,402,431

G

chymase 1

increases secretion

adefovir results in increased secretion of CMA1 protein

NCBI chr15:29,417,451...29,420,233
Ensembl chr15:29,417,451...29,420,233

G

cystatin C

multiple interactions
increases expression

[adefovir co-treated with Probenecid] results in increased expression of CST3 protein; [Probenecid co-treated with Valsartan co-treated with adefovir] results in increased expression of CST3 protein; [Probenecid co-treated with Valsartan] inhibits the reaction [adefovir results in increased expression of CST3 protein]; Cromolyn Sodium inhibits the reaction [[adefovir co-treated with Probenecid] results in increased expression of CST3 protein]

NCBI chr 3:136,336,923...136,340,796
Ensembl chr 3:136,336,920...136,340,822

G

hepatitis A virus cellular receptor 1

increases secretion

adefovir results in increased secretion of HAVCR1 protein

NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698

G

lipocalin 2

increases secretion

adefovir results in increased secretion of LCN2 protein

NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095

G

methylmalonyl-CoA mutase

affects expression
increases expression

adefovir affects the expression of MMUT mRNA mutant form; adefovir affects the expression of MMUT protein mutant form
adefovir results in increased expression of MMUT mRNA; adefovir results in increased expression of MMUT protein

PMID:19199343 PMID:19427250

NCBI chr 9:19,928,720...19,956,985
Ensembl chr 9:19,928,727...19,957,046

G

solute carrier family 22 member 6

increases uptake
multiple interactions
decreases expression
affects response to substance
increases response to substance

SLC22A6 protein results in increased uptake of adefovir
[adefovir co-treated with Probenecid co-treated with Cromolyn Sodium] affects the expression of SLC22A6 protein; [adefovir co-treated with Probenecid co-treated with Valsartan] affects the expression of SLC22A6 protein; [adefovir co-treated with Probenecid] results in decreased expression of SLC22A6 protein; Valsartan inhibits the reaction [[adefovir co-treated with Probenecid] results in decreased expression of SLC22A6 protein]
adefovir results in decreased expression of SLC22A6 protein
SLC22A6 protein affects the susceptibility to adefovir
adefovir inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]; Probenecid inhibits the reaction [SLC22A6 protein results in increased susceptibility to adefovir]; quercetin 3'-sulfate inhibits the reaction [SLC22A6 protein affects the susceptibility to adefovir]; SLC22A6 protein results in increased uptake of and results in increased susceptibility to adefovir

PMID:16857889 PMID:21244849 PMID:23856525 PMID:25448811 PMID:35114312

NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173

G

solute carrier family 22 member 8

increases response to substance
multiple interactions
decreases expression

SLC22A8 protein results in increased susceptibility to adefovir
[adefovir co-treated with Probenecid co-treated with Cromolyn Sodium] results in increased expression of SLC22A8 protein; [adefovir co-treated with Probenecid co-treated with Valsartan] results in increased expression of SLC22A8 protein; [adefovir co-treated with Probenecid] results in decreased expression of SLC22A8 protein; Cromolyn Sodium inhibits the reaction [[adefovir co-treated with Probenecid] results in decreased expression of SLC22A8 protein]
adefovir results in decreased expression of SLC22A8 protein

PMID:25448811 PMID:35114312

NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450

G

secreted phosphoprotein 1

increases secretion

adefovir results in increased secretion of SPP1 protein

NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162

G

transforming growth factor, beta 1

increases expression
multiple interactions

adefovir results in increased expression of TGFB1 protein
[adefovir co-treated with Probenecid] results in increased expression of TGFB1 protein; Cromolyn Sodium inhibits the reaction [[adefovir co-treated with Probenecid] results in increased expression of TGFB1 protein]; Valsartan inhibits the reaction [[adefovir co-treated with Probenecid] results in increased expression of TGFB1 protein]

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

adefovir pivoxil

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aryl hydrocarbon receptor

affects activity

adefovir dipivoxil affects the activity of AHR protein

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

adenylate kinase 4

increases expression

adefovir dipivoxil results in increased expression of AK4 mRNA

NCBI chr 5:116,039,222...116,099,064
Ensembl chr 5:116,039,616...116,098,618

G

aldo-keto reductase family 1, member C2

decreases expression

adefovir dipivoxil results in decreased expression of AKR1C2 mRNA

NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764

G

aldehyde dehydrogenase 18 family, member A1

decreases expression

adefovir dipivoxil results in decreased expression of ALDH18A1 mRNA

NCBI chr 1:239,375,657...239,407,956
Ensembl chr 1:239,375,669...239,407,890

G

aldehyde dehydrogenase 1 family, member A3

increases expression

adefovir dipivoxil results in increased expression of ALDH1A3 mRNA

NCBI chr 1:119,982,272...120,017,416
Ensembl chr 1:119,982,277...120,017,436

G

ALS2 C-terminal like

increases expression

adefovir dipivoxil results in increased expression of ALS2CL mRNA

NCBI chr 8:110,863,753...110,884,434
Ensembl chr 8:110,864,975...110,884,419

G

angiopoietin-like 4

increases expression

adefovir dipivoxil results in increased expression of ANGPTL4 mRNA

NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519

G

asparagine synthetase (glutamine-hydrolyzing)

decreases expression

adefovir dipivoxil results in decreased expression of ASNS mRNA

NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423

G

ATPase family, AAA domain containing 2

increases expression

adefovir dipivoxil results in increased expression of ATAD2 mRNA

NCBI chr 7:89,634,123...89,676,738
Ensembl chr 7:89,634,123...89,676,738

G

activating transcription factor 3

increases expression

adefovir dipivoxil results in increased expression of ATF3 mRNA

NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631

G

aurora kinase B

increases expression

adefovir dipivoxil results in increased expression of AURKB mRNA

NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837

G

Axl receptor tyrosine kinase

increases expression

adefovir dipivoxil results in increased expression of AXL mRNA

NCBI chr 1:81,265,088...81,296,278
Ensembl chr 1:81,265,088...81,296,265

G

BCL2 associated X, apoptosis regulator

increases expression

adefovir dipivoxil results in increased expression of BAX mRNA

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCAR3 adaptor protein, NSP family member

increases expression

adefovir dipivoxil results in increased expression of BCAR3 mRNA

NCBI chr 2:210,525,260...210,638,674
Ensembl chr 2:210,525,260...210,638,798

G

BEN domain containing 5

decreases expression

adefovir dipivoxil results in decreased expression of BEND5 mRNA

NCBI chr 5:126,290,648...126,336,662
Ensembl chr 5:125,254,956...126,534,367

G

Bcl2 modifying factor

decreases expression

adefovir dipivoxil results in decreased expression of BMF mRNA

NCBI chr 3:105,499,534...105,520,159
Ensembl chr 3:105,499,538...105,520,145

G

BTG anti-proliferation factor 2

increases expression

adefovir dipivoxil results in increased expression of BTG2 mRNA

NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628

G

cyclin E2

increases expression

adefovir dipivoxil results in increased expression of CCNE2 mRNA

NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632

G

cyclin-dependent kinase 6

increases expression

adefovir dipivoxil results in increased expression of CDK6 mRNA

NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634

G

cyclin-dependent kinase inhibitor 1A

increases expression

adefovir dipivoxil results in increased expression of CDKN1A mRNA

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

carboxymethylenebutenolidase homolog

increases expression

adefovir dipivoxil results in increased expression of CMBL mRNA

NCBI chr 2:82,569,257...82,591,007
Ensembl chr 2:82,571,888...82,591,009

G

cochlin

increases expression

adefovir dipivoxil results in increased expression of COCH mRNA

NCBI chr 6:69,031,139...69,045,124
Ensembl chr 6:69,031,167...69,045,109

G

collagen type IV alpha 1 chain

decreases expression

adefovir dipivoxil results in decreased expression of COL4A1 mRNA

NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412

G

cystathionine gamma-lyase

decreases expression

adefovir dipivoxil results in decreased expression of CTH mRNA

NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234

G

cathepsin C

decreases expression

adefovir dipivoxil results in decreased expression of CTSC mRNA

NCBI chr 1:142,028,386...142,059,841
Ensembl chr 1:142,028,392...142,060,387

G

cytochrome P450, family 1, subfamily b, polypeptide 1

increases expression

adefovir dipivoxil results in increased expression of CYP1B1 mRNA

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 3, subfamily a, polypeptide 2

decreases activity

adefovir dipivoxil results in decreased activity of CYP3A4 protein

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

damage specific DNA binding protein 2

increases expression

adefovir dipivoxil results in increased expression of DDB2 mRNA

NCBI chr 3:77,185,114...77,207,650
Ensembl chr 3:77,185,109...77,207,631

G

diacylglycerol kinase, alpha

increases expression

adefovir dipivoxil results in increased expression of DGKA mRNA

NCBI chr 7:1,148,734...1,175,324
Ensembl chr 7:1,148,735...1,175,110

G

DLG associated protein 5

increases expression

adefovir dipivoxil results in increased expression of DLGAP5 mRNA

NCBI chr15:20,633,964...20,664,569
Ensembl chr15:20,633,966...20,664,518

G

distal-less homeobox 1

decreases expression

adefovir dipivoxil results in decreased expression of DLX1 mRNA

NCBI chr 3:56,356,190...56,360,780
Ensembl chr 3:56,356,190...56,360,780

G

dynein axonemal intermediate chain 3

increases expression

adefovir dipivoxil results in increased expression of DNAI3 mRNA

NCBI chr 2:234,947,910...235,006,173
Ensembl chr 2:234,929,677...235,006,173

G

dihydropyrimidinase-like 3

increases expression

adefovir dipivoxil results in increased expression of DPYSL3 mRNA

NCBI chr18:35,374,427...35,480,228
Ensembl chr18:35,377,181...35,480,157

G

ephrin A1

decreases expression

adefovir dipivoxil results in decreased expression of EFNA1 mRNA

NCBI chr 2:174,681,676...174,689,061
Ensembl chr 2:174,681,682...174,690,866

G

endoplasmic reticulum oxidoreductase 1 alpha

increases expression

adefovir dipivoxil results in increased expression of ERO1A mRNA

NCBI chr15:18,495,037...18,530,440
Ensembl chr15:18,492,945...18,530,478

G

Fas cell surface death receptor

increases expression

adefovir dipivoxil results in increased expression of FAS mRNA

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

F-box protein 22

increases expression

adefovir dipivoxil results in increased expression of FBXO22 mRNA

NCBI chr 8:55,579,906...55,595,981
Ensembl chr 8:55,579,891...55,596,148

G

GABA type A receptor associated protein like 1

decreases expression

adefovir dipivoxil results in decreased expression of GABARAPL1 mRNA

NCBI chr 4:162,980,309...162,989,452
Ensembl chr 4:162,980,249...162,989,450

G

growth arrest and DNA-damage-inducible, alpha

increases expression

adefovir dipivoxil results in increased expression of GADD45A mRNA

NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115

G

polypeptide N-acetylgalactosaminyltransferase 16

decreases expression

adefovir dipivoxil results in decreased expression of GALNT16 mRNA

NCBI chr 6:100,168,943...100,250,718
Ensembl chr 6:100,170,306...100,250,705

G

glucosaminyl (N-acetyl) transferase 3, mucin type

increases expression

adefovir dipivoxil results in increased expression of GCNT3 mRNA

NCBI chr 8:70,689,173...70,696,476
Ensembl chr 8:70,686,844...70,699,562

G

growth differentiation factor 15

increases expression

adefovir dipivoxil results in increased expression of GDF15 mRNA

NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055

G

glutamic-oxaloacetic transaminase 1

decreases expression

adefovir dipivoxil results in decreased expression of GOT1 mRNA

NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633

G

G protein-coupled receptor 87

increases expression

adefovir dipivoxil results in increased expression of GPR87 mRNA

NCBI chr 2:143,439,741...143,440,901
Ensembl chr 2:143,439,735...143,458,190

G

H1.2 linker histone, cluster member

increases expression

adefovir dipivoxil results in increased expression of H1-2 mRNA

NCBI chr17:41,391,106...41,392,597
Ensembl chr17:41,388,477...41,392,635

G

heme oxygenase 1

decreases expression

adefovir dipivoxil results in decreased expression of HMOX1 mRNA

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

heat shock protein family A (Hsp70) member 1B

decreases expression

adefovir dipivoxil results in decreased expression of HSPA1B mRNA

NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240

G

interferon gamma

multiple interactions

adefovir dipivoxil inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased activity of NOS2 protein]; adefovir dipivoxil inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; adefovir dipivoxil inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein]

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

interleukin 19

increases secretion

adefovir dipivoxil results in increased secretion of IL19 protein

NCBI chr13:42,397,715...42,411,637
Ensembl chr13:42,399,138...42,405,473

G

lysine acetyltransferase 6B

decreases expression

adefovir dipivoxil results in decreased expression of KAT6B mRNA

NCBI chr15:2,638,885...2,811,977
Ensembl chr15:2,639,200...2,812,316

G

lysine demethylase 3A

decreases expression

adefovir dipivoxil results in decreased expression of KDM3A mRNA

NCBI chr 4:103,630,907...103,675,073
Ensembl chr 4:103,630,908...103,675,073

G

keratin 15

increases expression

adefovir dipivoxil results in increased expression of KRT15 mRNA

NCBI chr10:85,066,797...85,070,614
Ensembl chr10:85,066,802...85,171,799

G

laminin subunit alpha 3

increases expression

adefovir dipivoxil results in increased expression of LAMA3 mRNA

NCBI chr18:3,523,168...3,751,722
Ensembl chr18:3,523,133...3,751,353

G

lipocalin 2

increases secretion

adefovir dipivoxil results in increased secretion of LCN2 protein

NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095

G

mitogen-activated protein kinase kinase kinase 8

increases expression

adefovir dipivoxil results in increased expression of MAP3K8 mRNA

NCBI chr17:53,382,908...53,403,216
Ensembl chr17:53,383,131...53,403,216

G

MDM2 proto-oncogene

increases expression

adefovir dipivoxil results in increased expression of MDM2 mRNA

NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915

G

MAX interactor 1, dimerization protein

decreases expression

adefovir dipivoxil results in decreased expression of MXI1 mRNA

NCBI chr 1:252,323,915...252,383,682
Ensembl chr 1:252,323,303...252,383,681

G

non-SMC condensin I complex, subunit D2

increases expression

adefovir dipivoxil results in increased expression of NCAPD2 mRNA

NCBI chr 4:157,968,814...157,992,314
Ensembl chr 4:157,968,815...157,992,020

G

ninjurin 1

increases expression

adefovir dipivoxil results in increased expression of NINJ1 mRNA

NCBI chr17:15,452,804...15,461,684
Ensembl chr17:15,452,813...15,461,704

G

nitric oxide synthase 2

multiple interactions

adefovir dipivoxil inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased activity of NOS2 protein]; adefovir dipivoxil inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; adefovir dipivoxil inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein]

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

NAD(P)H quinone dehydrogenase 1

decreases expression

adefovir dipivoxil results in decreased expression of NQO1 mRNA

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

neuronal regeneration related protein

decreases expression

adefovir dipivoxil results in decreased expression of NREP mRNA

NCBI chr18:25,017,069...25,046,593
Ensembl chr18:25,017,083...25,046,591

G

nucleoside-triphosphatase, cancer-related

increases expression

adefovir dipivoxil results in increased expression of NTPCR mRNA

NCBI chr19:53,701,496...53,715,260
Ensembl chr19:53,695,976...53,715,202

G

prolyl 4-hydroxylase subunit alpha 1

decreases expression

adefovir dipivoxil results in decreased expression of P4HA1 mRNA

NCBI chr20:27,302,046...27,352,098
Ensembl chr20:27,302,141...27,352,786

G

pantothenate kinase 1

decreases expression

adefovir dipivoxil results in decreased expression of PANK1 mRNA

NCBI chr 1:232,324,718...232,395,445
Ensembl chr 1:232,328,430...232,396,829

G

protein disulfide isomerase family A, member 5

increases expression

adefovir dipivoxil results in increased expression of PDIA5 mRNA

NCBI chr11:65,272,152...65,359,087
Ensembl chr11:65,272,155...65,359,084

G

PDZ and LIM domain 1

increases expression

adefovir dipivoxil results in increased expression of PDLIM1 mRNA

NCBI chr 1:239,042,372...239,091,074
Ensembl chr 1:239,042,385...239,091,076

G

progesterone receptor

multiple interactions

adefovir dipivoxil binds to and results in decreased activity of PGR protein

NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344

G

pleckstrin homology-like domain, family A, member 3

increases expression

adefovir dipivoxil results in increased expression of PHLDA3 mRNA

NCBI chr13:47,193,250...47,196,335
Ensembl chr13:47,193,086...47,196,335

G

p53-induced death domain protein 1

increases expression

adefovir dipivoxil results in increased expression of PIDD1 mRNA

NCBI chr 1:196,536,815...196,542,808
Ensembl chr 1:196,536,834...196,542,699

G

pirin

increases expression

adefovir dipivoxil results in increased expression of PIR mRNA

NCBI chr X:30,108,536...30,219,269
Ensembl chr X:30,108,538...30,219,218

G

plectin

increases expression

adefovir dipivoxil results in increased expression of PLEC mRNA

NCBI chr 7:107,887,764...107,949,100
Ensembl chr 7:107,887,764...107,945,467

G

phorbol-12-myristate-13-acetate-induced protein 1

increases expression

adefovir dipivoxil results in increased expression of PMAIP1 mRNA

NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429

G

peroxisome proliferator-activated receptor gamma

affects activity

adefovir dipivoxil affects the activity of PPARG protein

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

protein phosphatase, Mg2+/Mn2+ dependent, 1D

increases expression

adefovir dipivoxil results in increased expression of PPM1D mRNA

NCBI chr10:70,172,603...70,208,607
Ensembl chr10:70,172,603...70,208,607

G

protein regulator of cytokinesis 1

increases expression

adefovir dipivoxil results in increased expression of PRC1 mRNA

NCBI chr 1:134,250,086...134,271,765
Ensembl chr 1:134,250,081...134,271,765

G

PR/SET domain 1

increases expression

adefovir dipivoxil results in increased expression of PRDM1 mRNA

NCBI chr20:47,959,858...47,981,488
Ensembl chr20:47,959,858...47,981,488

G

protein kinase AMP-activated non-catalytic subunit beta 2

decreases expression

adefovir dipivoxil results in decreased expression of PRKAB2 mRNA

NCBI chr 2:185,257,218...185,272,846
Ensembl chr 2:185,257,213...185,269,872

G

phosphoserine aminotransferase 1

decreases expression

adefovir dipivoxil results in decreased expression of PSAT1 mRNA

NCBI chr 1:213,196,709...213,218,564
Ensembl chr 1:213,196,709...213,218,682

G

retinoic acid receptor, alpha

decreases expression

adefovir dipivoxil results in decreased expression of RARA mRNA

NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142

G

ribosomal protein S27-like

increases expression

adefovir dipivoxil results in increased expression of RPS27L mRNA

NCBI chr 8:67,562,483...67,567,418
Ensembl chr 8:67,562,483...67,567,418

G

ribonucleotide reductase regulatory TP53 inducible subunit M2B

increases expression

adefovir dipivoxil results in increased expression of RRM2B mRNA

NCBI chr 7:69,077,024...69,108,742
Ensembl chr 7:69,078,291...69,108,633

G

serpin family B member 5

increases expression

adefovir dipivoxil results in increased expression of SERPINB5 mRNA

NCBI chr13:22,985,557...23,005,756
Ensembl chr13:22,985,557...23,005,756