copper chelator - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	copper chelator	go back to main search page
Accession:	CHEBI:166831	browse the term
Definition:	A chelator that is any compound containing a ligand (typically organic) which is able to form a bond to a central copper atom at two or more points.
Synonyms:	related_synonym:	copper chelate; copper chelating agent; copper chelating agents; copper chelators
	xref:	PMID:24934357; PMID:29710396

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Rat (665) Mouse (659) Human (682) Chinchilla (0) Bonobo (0) Dog (1) Squirrel (0) Pig (13) Green Monkey (0) Naked Mole-rat (0) All
Genes (665)

2,2,2-tetramine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetyl-CoA carboxylase alpha

multiple interactions

Trientine inhibits the reaction [Metformin results in increased phosphorylation of ACACA protein]

NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457

G

acyl-CoA dehydrogenase medium chain

multiple interactions

Trientine inhibits the reaction [Streptozocin results in decreased expression of ACADM protein]

NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147

G

acetyl-CoA acetyltransferase 1

multiple interactions

Trientine inhibits the reaction [Streptozocin results in decreased expression of ACAT1 protein]

NCBI chr 8:53,979,813...54,008,861
Ensembl chr 8:53,979,813...54,008,855

G

aconitase 2

multiple interactions

Trientine inhibits the reaction [Streptozocin results in decreased expression of ACO2 protein]

NCBI chr 7:113,385,677...113,428,794
Ensembl chr 7:113,385,646...113,428,261

G

actin, alpha, cardiac muscle 1

decreases expression

Trientine results in decreased expression of ACTC1 protein

NCBI chr 3:100,811,987...100,817,523
Ensembl chr 3:100,811,987...100,817,523

G

actinin alpha 4

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of ACTN4 protein]

NCBI chr 1:84,182,783...84,251,867
Ensembl chr 1:84,182,788...84,251,847

G

aminoacylase 1

multiple interactions

Trientine inhibits the reaction [Streptozocin results in decreased expression of ACY1 protein]

NCBI chr 8:107,072,354...107,077,756
Ensembl chr 8:107,072,358...107,077,682

G

advanced glycosylation end product-specific receptor

decreases expression
multiple interactions

Trientine results in decreased expression of AGER protein
Trientine results in decreased expression of AGER mRNA; Trientine results in decreased expression of AGER protein
Tetradecanoylphorbol Acetate inhibits the reaction [Trientine inhibits the reaction [S100B protein results in increased expression of AGER protein]]; Trientine inhibits the reaction [S100B protein results in increased expression of AGER protein]

NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078

G

alanine-glyoxylate aminotransferase 2

multiple interactions

Trientine inhibits the reaction [Streptozocin results in decreased expression of AGXT2 protein]

NCBI chr 2:59,336,252...59,377,664
Ensembl chr 2:59,336,283...59,377,926

G

apoptosis inducing factor, mitochondria associated 1

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of AIFM1 protein]

NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256

G

adenylate kinase 4

multiple interactions

Trientine inhibits the reaction [Streptozocin results in decreased expression of AK4 protein]

NCBI chr 5:116,039,222...116,099,064
Ensembl chr 5:116,039,616...116,098,618

G

aldo-keto reductase family 1 member A1

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of AKR1A1 protein]

NCBI chr 5:130,092,945...130,130,277
Ensembl chr 5:130,092,732...130,113,674

G

aldolase, fructose-bisphosphate B

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of ALDOB protein]

NCBI chr 5:63,889,045...63,902,086
Ensembl chr 5:63,889,046...63,902,116

G

alanyl aminopeptidase, membrane

multiple interactions

Trientine inhibits the reaction [Streptozocin results in decreased expression of ANPEP protein]

NCBI chr 1:133,767,332...133,810,137
Ensembl chr 1:133,767,332...133,785,789

G

annexin A3

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of ANXA3 protein]

NCBI chr14:12,727,708...12,781,717
Ensembl chr14:12,719,795...12,781,617

G

annexin A5

multiple interactions

Trientine inhibits the reaction [Streptozocin results in decreased expression of ANXA5 protein]; Trientine inhibits the reaction [Streptozocin results in increased expression of ANXA5 protein]

PMID:19634143 PMID:21136691

NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369

G

apolipoprotein A1

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of APOA1 protein]

NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035

G

amyloid beta precursor protein

multiple interactions
decreases cleavage
decreases expression
increases metabolic processing

Trientine inhibits the reaction [[[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of phosphatidylcholine hydroperoxide] which results in increased chemical synthesis of 4-hydroxy-2-nonenal]; Trientine inhibits the reaction [[[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of Phosphatidylcholines] which results in increased chemical synthesis of phosphatidylcholine hydroperoxide]; Trientine inhibits the reaction [APP protein results in increased activity of CASP3 protein]
Trientine results in decreased expression of and affects the localization of APP protein modified form
Trientine results in decreased cleavage of APP protein
Trientine results in decreased expression of APP protein modified form
Trientine results in increased metabolism of APP protein

PMID:10940226 PMID:12963085 PMID:17964426 PMID:23541064

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

aquaporin 1

multiple interactions

Trientine inhibits the reaction [Streptozocin results in decreased expression of AQP1 protein]

NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690

G

argininosuccinate synthase 1

decreases expression

Trientine results in decreased expression of ASS1 protein

NCBI chr 3:14,747,355...14,796,909
Ensembl chr 3:14,747,368...14,796,903

G

ATP synthase F1 subunit alpha

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of ATP5F1A protein]

NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794

G

ATP synthase F1 subunit beta

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of ATP5F1B protein]

NCBI chr 7:515,454...521,858
Ensembl chr 7:515,460...567,273

G

ATP synthase membrane subunit f

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of ATP5MF protein]

NCBI chr12:9,421,665...9,428,236
Ensembl chr12:9,421,579...9,428,236

G

ATP synthase peripheral stalk subunit OSCP

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of ATP5PO protein]

NCBI chr11:31,165,218...31,171,530
Ensembl chr11:31,165,217...31,171,592

G

ATPase H+ transporting V1 subunit A

decreases expression

Trientine results in decreased expression of ATP6V1A protein

NCBI chr11:56,561,444...56,614,694
Ensembl chr11:56,560,974...56,614,694

G

ATPase H+ transporting V1 subunit B2

decreases expression

Trientine results in decreased expression of ATP6V1B2 protein

NCBI chr16:20,617,515...20,641,651
Ensembl chr16:20,617,518...20,641,745

G

ATPase copper transporting alpha

increases expression

Trientine results in increased expression of ATP7A mRNA; Trientine results in increased expression of ATP7A protein

NCBI chr X:71,094,144...71,201,550
Ensembl chr X:71,094,202...71,198,354

G

beta-secretase 1

multiple interactions
decreases expression

Tetradecanoylphorbol Acetate inhibits the reaction [Trientine inhibits the reaction [S100B protein results in increased expression of BACE1 protein]]; Trientine inhibits the reaction [S100B protein results in increased expression of BACE1 protein]
Trientine results in decreased expression of BACE1 protein

NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876

G

BCL2, apoptosis regulator

decreases expression
increases expression
multiple interactions

Trientine results in decreased expression of BCL2 protein
Trientine results in increased expression of BCL2 protein
Copper Sulfate inhibits the reaction [Trientine results in increased expression of BCL2 protein]

PMID:11369509 PMID:14513838

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

calmodulin 3

multiple interactions

Trientine inhibits the reaction [Streptozocin results in decreased expression of CALM3 protein]

NCBI chr 1:77,590,668...77,597,776
Ensembl chr 1:77,589,230...77,592,207

G

calreticulin

multiple interactions

Trientine inhibits the reaction [Streptozocin results in decreased expression of CALR protein]

NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414

G

caspase 3

multiple interactions
increases activity

Paraquat promotes the reaction [Trientine results in increased activity of CASP3 protein]; Trientine inhibits the reaction [APP protein results in increased activity of CASP3 protein]

PMID:11369509 PMID:12963085 PMID:14513838 PMID:22362149

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 9

increases activity

Trientine results in increased activity of CASP9 protein

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

copper chaperone for superoxide dismutase

multiple interactions

Trientine inhibits the reaction [Streptozocin results in decreased expression of CCS mRNA]; Trientine inhibits the reaction [Streptozocin results in decreased expression of CCS protein]

NCBI chr 1:202,113,792...202,134,931
Ensembl chr 1:202,113,804...202,134,915

G

CDGSH iron sulfur domain 1

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of CISD1 protein]

NCBI chr20:17,255,302...17,268,688
Ensembl chr20:17,255,151...17,284,924

G

clusterin

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of CLU protein]

NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315

G

collagen type VI alpha 1 chain

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of COL6A1 protein]

NCBI chr20:11,906,105...11,924,599
Ensembl chr20:11,905,957...11,924,597

G

collagen type VI alpha 2 chain

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of COL6A2 protein]

NCBI chr20:12,021,676...12,049,425
Ensembl chr20:12,021,767...12,057,564

G

collagen type VI alpha 3 chain

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of COL6A3 protein]

NCBI chr 9:91,361,578...91,439,434
Ensembl chr 9:91,361,583...91,439,471

G

ceruloplasmin

decreases expression

Trientine results in decreased expression of CP protein

NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075

G

carnitine palmitoyltransferase 2

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of CPT2 protein]

NCBI chr 5:122,664,677...122,682,126
Ensembl chr 5:122,664,677...122,682,095

G

crystallin zeta

multiple interactions

Trientine inhibits the reaction [Streptozocin results in decreased expression of CRYZ protein]

NCBI chr 2:243,552,037...243,580,369
Ensembl chr 2:243,552,119...243,579,758

G

citrate synthase

increases expression

Trientine results in increased expression of CS protein

NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421

G

cytochrome c-1

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of CYC1 protein]

NCBI chr 7:108,067,106...108,069,483
Ensembl chr 7:108,067,115...108,069,479

G

cytochrome P450, family 4, subfamily a, polypeptide 2

multiple interactions

Trientine promotes the reaction [Streptozocin results in decreased expression of CYP4A2 protein]

NCBI chr 5:128,922,355...128,934,188
Ensembl chr 5:128,923,615...128,934,165

G

D-amino-acid oxidase

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of DAO protein]

NCBI chr12:42,592,342...42,613,046
Ensembl chr12:42,592,343...42,612,741

G

dihydrolipoamide S-acetyltransferase

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of DLAT protein]

NCBI chr 8:50,979,151...51,004,435
Ensembl chr 8:50,978,051...51,004,479
Ensembl chr 1:50,978,051...51,004,479

G

dihydrolipoamide dehydrogenase

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of DLD protein]

NCBI chr 6:47,904,153...47,924,814
Ensembl chr 6:47,903,914...47,924,795

G

dihydrolipoamide S-succinyltransferase

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of DLST protein]

PMID:19634143 PMID:21136691

NCBI chr 6:104,758,511...104,783,296
Ensembl chr 6:104,758,631...104,783,296

G

enolase 1, pseudogene 1

multiple interactions

Trientine inhibits the reaction [Streptozocin results in decreased expression of ENO1-PS1 protein]

NCBI chr 3:57,576,643...57,578,321
Ensembl chr 3:57,576,709...57,578,013

G

epoxide hydrolase 1

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of EPHX1 protein]

NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235

G

electron transfer flavoprotein subunit alpha

multiple interactions

Trientine inhibits the reaction [Streptozocin results in decreased expression of ETFA protein]

NCBI chr 8:55,835,115...55,891,890
Ensembl chr 8:55,835,134...55,891,969

G

electron transfer flavoprotein subunit beta

multiple interactions

Trientine inhibits the reaction [Streptozocin results in decreased expression of ETFB protein]

NCBI chr 1:93,851,908...93,866,072
Ensembl chr 1:93,851,858...93,866,068

G

fibronectin 1

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of FN1 mRNA]

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

FXYD domain-containing ion transport regulator 2

increases expression

Trientine results in increased expression of FXYD2 protein

NCBI chr 8:45,712,901...45,720,032
Ensembl chr 8:45,712,903...45,720,203

G

glucose-6-phosphatase catalytic subunit 1

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of G6PC1 protein]

NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804

G

glycine amidinotransferase

multiple interactions

Trientine inhibits the reaction [Streptozocin results in decreased expression of GATM protein]

NCBI chr 3:109,658,919...109,675,508
Ensembl chr 3:109,658,951...109,684,129

G

gamma-glutamyltransferase 1

multiple interactions

Trientine inhibits the reaction [Streptozocin results in decreased expression of GGT1 protein]

NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442

G

G protein subunit gamma 12

increases expression

Trientine results in increased expression of GNG12 protein

NCBI chr 4:96,011,118...96,134,767
Ensembl chr 4:96,010,952...96,134,712

G

glutamic-oxaloacetic transaminase 2

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of GOT2 protein]

NCBI chr19:9,174,304...9,199,995
Ensembl chr19:9,174,311...9,199,994

G

glutathione peroxidase 1

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of GPX1 protein]

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

glutathione peroxidase 3

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of GPX3 protein]

NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035

G

glutathione S-transferase alpha 2

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of GSTA2 protein]

NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798

G

glutathione S-transferase alpha 3

multiple interactions

Trientine inhibits the reaction [Streptozocin results in decreased expression of GSTA3 protein]

NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240

G

glutathione S-transferase pi 1

decreases expression

Trientine results in decreased expression of GSTP1 protein

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

hydroxyacid oxidase 2

multiple interactions

Trientine inhibits the reaction [Streptozocin results in decreased expression of HAO2 protein]

NCBI chr 2:186,200,137...186,232,997
Ensembl chr 2:186,200,504...186,224,425

G

hemoglobin subunit beta

multiple interactions

Trientine inhibits the reaction [Streptozocin results in decreased expression of HBB-B1 protein]

NCBI chr 1:158,250,421...158,251,832
Ensembl chr 1:158,120,200...158,252,012

G

heme oxygenase 1

multiple interactions

Trientine inhibits the reaction [Dimethyldithiocarbamate results in increased expression of HMOX1 protein]; Trientine inhibits the reaction [Ziram results in increased expression of HMOX1 protein]

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

hydroxysteroid (17-beta) dehydrogenase 10

multiple interactions

Trientine inhibits the reaction [Streptozocin results in decreased expression of HSD17B10 protein]

NCBI chr X:21,089,142...21,091,603
Ensembl chr X:21,089,122...21,109,488

G

heat shock protein family A (Hsp70) member 5

multiple interactions

Trientine inhibits the reaction [Streptozocin results in decreased expression of HSPA5 protein]

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

heat shock protein family A (Hsp70) member 9

multiple interactions

Trientine inhibits the reaction [Streptozocin results in decreased expression of HSPA9 protein]

NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292

G

heat shock protein family D (Hsp60) member 1

multiple interactions

Trientine inhibits the reaction [Streptozocin results in decreased expression of HSPD1 protein]; Trientine inhibits the reaction [Streptozocin results in increased expression of HSPD1 protein]

PMID:19634143 PMID:21136691

NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662

G

heat shock protein family E (Hsp10) member 1

multiple interactions

Trientine inhibits the reaction [Streptozocin results in decreased expression of HSPE1 protein]

NCBI chr 9:56,589,912...56,593,000
Ensembl chr 9:56,589,789...56,593,089

G

heparan sulfate proteoglycan 2

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of HSPG2 protein]

NCBI chr 5:149,677,437...149,778,594
Ensembl chr 5:149,677,476...149,778,594

G

insulin 2

multiple interactions

Trientine inhibits the reaction [[Copper co-treated with Ascorbic Acid] results in increased oxidation of and affects the folding of INS protein]

NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775

G

lactate dehydrogenase B

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of LDHB protein]

PMID:19634143 PMID:21136691

NCBI chr 4:175,428,382...175,446,403
Ensembl chr 4:175,428,385...175,446,403

G

malate dehydrogenase 1

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of MDH1 protein]

NCBI chr14:95,630,625...95,645,920
Ensembl chr14:95,630,306...95,645,925

G

malate dehydrogenase 2

multiple interactions

Trientine inhibits the reaction [Streptozocin results in decreased expression of MDH2 protein]

NCBI chr12:20,894,269...20,907,225
Ensembl chr12:20,894,262...20,907,271

G

membrane metallo-endopeptidase

multiple interactions

Trientine inhibits the reaction [Streptozocin results in decreased expression of MME protein]

NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792

G

NADH:ubiquinone oxidoreductase subunit A10

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of NDUFA10 protein]

NCBI chr 9:93,007,034...93,041,825
Ensembl chr 9:93,007,042...93,042,560

G

NADH:ubiquinone oxidoreductase subunit AB1

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of NDUFAB1 protein]

NCBI chr 1:176,644,696...176,658,131
Ensembl chr 1:176,644,703...176,658,099

G

NADH:ubiquinone oxidoreductase core subunit S2

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of NDUFS2 protein]

NCBI chr13:83,654,402...83,671,474
Ensembl chr13:83,654,406...83,671,420

G

NADH:ubiquinone oxidoreductase subunit S4

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of NDUFS4 protein]

NCBI chr 2:45,951,327...46,061,829
Ensembl chr 2:45,951,313...46,061,846

G

NADH:ubiquinone oxidoreductase core subunit V2

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of NDUFV2 protein]

NCBI chr 9:105,690,454...105,710,669
Ensembl chr 9:105,690,455...105,710,713

G

nicotinamide nucleotide transhydrogenase

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of NNT protein]

NCBI chr 2:51,411,413...51,505,125
Ensembl chr 2:51,411,413...51,504,823

G

ornithine aminotransferase

multiple interactions

Trientine inhibits the reaction [Streptozocin results in decreased expression of OAT protein]

NCBI chr 1:187,347,862...187,367,644
Ensembl chr 1:187,347,865...187,367,682

G

oxoglutarate dehydrogenase

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of OGDH protein]

NCBI chr14:81,150,021...81,217,479
Ensembl chr14:81,150,091...81,217,479

G

pyruvate carboxylase

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of PC protein]

NCBI chr 1:201,799,374...201,898,412
Ensembl chr 1:201,804,267...201,898,380

G

phosphoenolpyruvate carboxykinase 1

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of PCK1 protein]

NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191

G

prohibitin 1

decreases expression

Trientine results in decreased expression of PHB1 protein

NCBI chr10:80,605,268...80,618,043
Ensembl chr10:80,605,251...80,618,042

G

podocalyxin-like

increases expression

Trientine results in increased expression of PODXL protein

NCBI chr 4:60,135,124...60,181,829
Ensembl chr 4:60,135,109...60,181,899

G

peptidylprolyl isomerase A

multiple interactions

Trientine inhibits the reaction [Copper results in decreased secretion of PPIA protein]

NCBI chr14:81,279,292...81,282,960
Ensembl chr14:81,275,091...81,299,601

G

prion protein

increases expression
affects response to substance

Trientine results in increased expression of PRNP mRNA; Trientine results in increased expression of PRNP protein
PRNP protein affects the susceptibility to Trientine

NCBI chr 3:119,186,073...119,201,513
Ensembl chr 3:119,177,485...119,203,937

G

pyridine nucleotide-disulphide oxidoreductase domain 2

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of PYROXD2 protein]

NCBI chr 1:241,523,278...241,549,083
Ensembl chr 1:241,523,377...241,548,761

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

Trientine results in decreased expression of and affects the localization of RELA protein

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

ribosomal protein S6

multiple interactions
increases phosphorylation

Trientine inhibits the reaction [Metformin results in decreased phosphorylation of RPS6 protein]
Trientine results in increased phosphorylation of RPS6 protein

NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602

G

S100 calcium binding protein B

multiple interactions

Tetradecanoylphorbol Acetate inhibits the reaction [Trientine inhibits the reaction [S100B protein results in increased expression of AGER protein]]; Tetradecanoylphorbol Acetate inhibits the reaction [Trientine inhibits the reaction [S100B protein results in increased expression of BACE1 protein]]; Trientine inhibits the reaction [S100B protein results in increased expression of AGER protein]; Trientine inhibits the reaction [S100B protein results in increased expression of BACE1 protein]

NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743

G

succinate dehydrogenase complex flavoprotein subunit A

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of SDHA protein]

PMID:19634143 PMID:21136691

NCBI chr 1:28,935,965...28,960,936
Ensembl chr 1:28,940,164...28,961,535

G

succinate dehydrogenase complex iron sulfur subunit B

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of SDHB protein]

NCBI chr 5:153,264,906...153,285,570
Ensembl chr 5:153,264,899...153,314,293

G

serpin family E member 1

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of SERPINE1 mRNA]

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

G

sideroflexin 1

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of SFXN1 protein]

NCBI chr17:10,486,250...10,522,640
Ensembl chr17:10,486,271...10,522,529

G

solute carrier family 22 member 6

multiple interactions

Trientine inhibits the reaction [Streptozocin results in decreased expression of SLC22A6 protein]

NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173

G

solute carrier family 25 member 10

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of SLC25A10 protein]

NCBI chr10:105,765,598...105,775,159
Ensembl chr10:105,765,372...105,773,556

G

solute carrier family 25 member 3

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of SLC25A3 protein]

NCBI chr 7:25,611,937...25,619,401
Ensembl chr 7:25,586,725...25,667,727

G

solute carrier family 25 member 5

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of SLC25A5 protein]

NCBI chr X:116,031,896...116,034,963
Ensembl chr X:116,031,803...116,034,967

G

solute carrier family 31 member 1

increases expression
multiple interactions

Trientine results in increased expression of SLC31A1 mRNA
Trientine results in increased expression of SLC31A1 mRNA; Trientine results in increased expression of SLC31A1 protein
[Trientine results in increased expression of SLC31A1 mRNA] which results in decreased susceptibility to oxaliplatin; [Trientine results in increased expression of SLC31A1 mRNA] which results in increased susceptibility to Carboplatin; [Trientine results in increased expression of SLC31A1 mRNA] which results in increased susceptibility to Cisplatin; Trientine promotes the reaction [SLC31A1 protein results in increased uptake of Platinum]

PMID:22362149 PMID:22491798 PMID:22914438

NCBI chr 5:75,814,744...75,844,241
Ensembl chr 5:75,814,743...75,844,228

G

solute carrier family 31 member 2

multiple interactions

Trientine promotes the reaction [Streptozocin results in increased expression of SLC31A2 mRNA]; Trientine promotes the reaction [Streptozocin results in increased expression of SLC31A2 protein]

NCBI chr 5:75,738,008...75,748,542
Ensembl chr 5:75,738,024...75,748,542

G

solute carrier family 3 member 1

multiple interactions

Trientine inhibits the reaction [Streptozocin results in decreased expression of SLC3A1 protein]

NCBI chr 6:9,608,169...9,641,881
Ensembl chr 6:9,608,178...9,641,907

G

SMAD family member 4

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of SMAD4 mRNA]

NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438

G

synaptosome associated protein 25

increases expression

Trientine results in increased expression of SNAP25 protein

NCBI chr 3:124,041,898...124,123,761
Ensembl chr 3:124,041,898...124,123,760

G

superoxide dismutase 1

decreases expression
increases activity
decreases activity
multiple interactions

Trientine results in decreased expression of SOD1 protein
Trientine results in increased activity of SOD1 protein
Trientine results in decreased activity of SOD1 protein
Chlorpromazine inhibits the reaction [Copper inhibits the reaction [Trientine results in decreased activity of SOD1 protein]]; Copper inhibits the reaction [Trientine results in decreased activity of SOD1 protein]; Sucrose inhibits the reaction [Copper inhibits the reaction [Trientine results in decreased activity of SOD1 protein]]; Trientine inhibits the reaction [Streptozocin results in decreased expression of and results in decreased activity of SOD1 protein]; Trientine inhibits the reaction [Streptozocin results in decreased expression of SOD1 protein]
[Trientine results in decreased abundance of Copper] which results in decreased activity of SOD1 protein; Copper Sulfate inhibits the reaction [Trientine results in decreased activity of SOD1 protein]

PMID:11369509 PMID:14513838 PMID:19634143 PMID:21140194 PMID:22362149 More...

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

multiple interactions

Trientine inhibits the reaction [Streptozocin results in decreased expression of SOD2 protein]
Trientine results in increased expression of and results in increased activity of SOD2 protein

PMID:14513838 PMID:19634143

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

superoxide dismutase 3

multiple interactions

Trientine inhibits the reaction [Streptozocin results in decreased expression of SOD3 mRNA]; Trientine inhibits the reaction [Streptozocin results in decreased expression of SOD3 protein]

NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990

G

synaptophysin

increases expression

Trientine results in increased expression of SYP protein

NCBI chr X:14,849,444...14,864,553
Ensembl chr X:14,849,444...14,864,745

G

transforming growth factor, beta 1

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of TGFB1 mRNA]

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

tubulointerstitial nephritis antigen

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of TINAG protein]

NCBI chr 8:77,800,031...77,885,077
Ensembl chr 8:77,800,032...77,885,077

G

tumor protein p53

multiple interactions
increases phosphorylation

Paraquat promotes the reaction [Trientine results in increased phosphorylation of TP53 protein]; Trientine results in increased expression of and results in increased activity of TP53 protein

PMID:11369509 PMID:14513838

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

transthyretin

multiple interactions

Trientine inhibits the reaction [Streptozocin results in decreased expression of TTR protein]

NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008

G

ubiquitin-like modifier activating enzyme 1

multiple interactions

Trientine inhibits the reaction [Dimethyldithiocarbamate results in decreased activity of and results in decreased ubiquitination of UBA1 protein]; Trientine inhibits the reaction [Ziram results in decreased activity of and results in decreased ubiquitination of UBA1 protein]

NCBI chr X:1,508,700...1,530,677
Ensembl chr X:1,508,666...1,530,636

G

ubiquinol-cytochrome c reductase core protein 1

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of UQCRC1 protein]

PMID:19634143 PMID:21136691

NCBI chr 8:109,589,735...109,601,481
Ensembl chr 8:109,589,706...109,601,480

G

voltage-dependent anion channel 1

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of VDAC1 protein]

NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640

G

voltage-dependent anion channel 2

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of VDAC2 protein]

NCBI chr15:2,462,877...2,476,802
Ensembl chr15:2,463,056...2,476,553

5-chloro-7-iodoquinolin-8-ol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetylcholinesterase

multiple interactions

Clioquinol inhibits the reaction [[Copper co-treated with Cholesterol] results in increased activity of ACHE protein]

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

argonaute RISC catalytic component 2

multiple interactions

[Clioquinol co-treated with zinc chloride] results in decreased expression of AGO2 mRNA; [Clioquinol co-treated with zinc chloride] results in decreased expression of AGO2 protein

NCBI chr 7:105,018,202...105,105,118
Ensembl chr 7:105,029,120...105,104,974

G

adenylate kinase 1

decreases expression

Clioquinol results in decreased expression of AK1 mRNA

NCBI chr 3:15,912,431...15,923,045
Ensembl chr 3:15,912,485...15,923,041

G

AKT serine/threonine kinase 1

multiple interactions

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Clioquinol co-treated with Copper] results in increased phosphorylation of AKT1 protein]; [Clioquinol co-treated with Copper] results in increased phosphorylation of AKT1 protein

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

amyloid beta precursor protein

multiple interactions

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Clioquinol binds to Copper] which results in increased degradation of APP protein modified form]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Clioquinol co-treated with Copper] results in decreased expression of APP protein alternative form]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [[Clioquinol binds to Copper] which results in increased degradation of APP protein modified form]; [Clioquinol binds to Copper] which results in increased degradation of APP protein modified form; [Clioquinol co-treated with Copper] results in decreased expression of APP protein alternative form; Clioquinol inhibits the reaction [Copper results in increased secretion of APP protein alternative form]; Clioquinol inhibits the reaction [Zinc results in increased secretion of APP protein alternative form]; pyrazolanthrone inhibits the reaction [[Clioquinol co-treated with Copper] results in decreased expression of APP protein alternative form]

PMID:16648635 PMID:18346929

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

androgen receptor

multiple interactions

[Clioquinol binds to Copper] which results in decreased expression of AR protein

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

activating transcription factor 3

increases expression

Clioquinol results in increased expression of ATF3 mRNA

NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631

G

ATM serine/threonine kinase

increases phosphorylation

Clioquinol results in increased phosphorylation of ATM protein

NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437

G

antioxidant 1 copper chaperone

increases oxidation

Clioquinol results in increased oxidation of ATOX1 protein

NCBI chr10:39,564,855...39,579,892
Ensembl chr10:39,564,857...39,579,950

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2

decreases expression
multiple interactions

Clioquinol results in decreased expression of ATP2A2 mRNA; Clioquinol results in decreased expression of ATP2A2 protein
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Clioquinol results in decreased expression of ATP2A2 mRNA]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Clioquinol results in decreased expression of ATP2A2 protein]; Calcium promotes the reaction [Clioquinol results in decreased expression of ATP2A2 mRNA]; Calcium promotes the reaction [Clioquinol results in decreased expression of ATP2A2 protein]

NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101

G

beclin 1

increases expression

Clioquinol results in increased expression of BECN1 protein

NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742

G

BCL2 interacting protein 3 like

decreases expression

Clioquinol results in decreased expression of BNIP3L mRNA

NCBI chr15:41,174,594...41,197,730
Ensembl chr15:41,174,594...41,197,803

G

calreticulin

decreases expression

Clioquinol results in decreased expression of CALR mRNA; Clioquinol results in decreased expression of CALR protein

NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414

G

caspase 3

multiple interactions

Clioquinol inhibits the reaction [Isoflurane results in increased cleavage of and results in increased activity of CASP3 protein]

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

cyclin-dependent kinase inhibitor 1A

increases expression

Clioquinol results in increased expression of CDKN1A mRNA

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

copper metabolism domain containing 1

affects response to substance

COMMD1 gene SNP affects the susceptibility to Clioquinol

NCBI chr14:96,880,463...96,984,494
Ensembl chr14:96,880,463...96,984,501

G

dopamine beta-hydroxylase

increases expression
decreases secretion

Clioquinol results in increased expression of DBH mRNA
Clioquinol results in decreased secretion of DBH protein

NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248

G

decapping mRNA 1B

multiple interactions

[Clioquinol co-treated with zinc chloride] results in decreased expression of DCP1B mRNA

NCBI chr 4:152,358,267...152,395,747
Ensembl chr 4:152,358,241...152,397,145

G

DNA-damage inducible transcript 3

decreases expression

Clioquinol results in decreased expression of DDIT3 mRNA

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

dicer 1 ribonuclease III

multiple interactions

[Clioquinol co-treated with zinc chloride] results in decreased expression of DICER1 protein

NCBI chr 6:123,627,529...123,692,278
Ensembl chr 6:123,631,250...123,693,965

G

drosha ribonuclease III

multiple interactions

[Clioquinol co-treated with zinc chloride] affects the expression of DROSHA protein

NCBI chr 2:61,864,886...61,976,688
Ensembl chr 2:61,864,970...61,976,688

G

epidermal growth factor receptor

multiple interactions

4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [[Copper binds to Clioquinol] which results in increased phosphorylation of EGFR protein]; [4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline results in decreased phosphorylation of and results in decreased activity of EGFR protein] inhibits the reaction [[Copper binds to Clioquinol] which results in increased phosphorylation of MAPK1 protein]; [4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline results in decreased phosphorylation of and results in decreased activity of EGFR protein] inhibits the reaction [[Copper binds to Clioquinol] which results in increased phosphorylation of MAPK3 protein]; [[Clioquinol binds to Copper] which results in increased activity of SRC protein] which results in increased phosphorylation of and results in increased activity of EGFR protein; [Clioquinol binds to Copper] which results in increased phosphorylation of EGFR protein; [FN1 protein co-treated with [Clioquinol binds to Copper]] results in increased expression of EGFR protein; AG 1879 inhibits the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of and results in increased activity of EGFR protein]; FN1 protein promotes the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of EGFR protein]; ITGA2 protein promotes the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of EGFR protein]; ITGA5 protein promotes the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of EGFR protein]

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

egl-9 family hypoxia-inducible factor 1

decreases expression

Clioquinol results in decreased expression of EGLN1 mRNA

NCBI chr19:52,867,900...52,907,308
Ensembl chr19:52,869,486...52,907,777

G

egl-9 family hypoxia-inducible factor 2

decreases expression

Clioquinol results in decreased expression of EGLN2 mRNA

NCBI chr 1:82,451,554...82,459,809
Ensembl chr 1:82,451,555...82,459,751

G

early growth response 1

increases expression

Clioquinol results in increased expression of EGR1 mRNA

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

eukaryotic translation initiation factor 4E

multiple interactions

[Clioquinol co-treated with zinc chloride] results in increased expression of EIF4E mRNA; [Clioquinol co-treated with zinc chloride] results in increased expression of EIF4E protein

NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683

G

erythropoietin

increases expression
decreases expression

Clioquinol results in increased expression of EPO mRNA
Clioquinol results in decreased expression of EPO mRNA

PMID:16973622 PMID:19502547

NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946

G

fibronectin 1

multiple interactions

[FN1 protein co-treated with [Clioquinol binds to Copper]] results in increased expression of EGFR protein; FN1 protein promotes the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of EGFR protein]

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

Clioquinol promotes the reaction [FOS protein binds to CXCL8 promoter]

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

growth arrest and DNA-damage-inducible, alpha

increases expression

Clioquinol results in increased expression of GADD45A mRNA

NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115

G

GATA binding protein 2

decreases expression
multiple interactions

Clioquinol results in decreased expression of GATA2 protein
GATA2 protein inhibits the reaction [Clioquinol results in increased expression of CXCL8 mRNA]; GATA2 protein inhibits the reaction [Clioquinol results in increased secretion of CXCL8 protein]

NCBI chr 4:120,654,205...120,667,763
Ensembl chr 4:120,658,986...120,667,761

G

GATA binding protein 3

decreases expression
multiple interactions

Clioquinol results in decreased expression of GATA3 protein
Clioquinol inhibits the reaction [GATA3 protein binds to CXCL8 promoter]; GATA3 protein inhibits the reaction [Clioquinol results in increased expression of CXCL8 mRNA]; GATA3 protein inhibits the reaction [Clioquinol results in increased secretion of CXCL8 protein]

NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391

G

H2A.X variant histone

increases phosphorylation

Clioquinol results in increased phosphorylation of H2AX protein

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239

G

hypoxia inducible factor 1 subunit alpha

multiple interactions
increases expression
decreases hydroxylation
decreases ubiquitination
increases activity

[Zinc co-treated with Copper] inhibits the reaction [Clioquinol results in increased expression of HIF1A protein]; Clioquinol inhibits the reaction [HIF1AN protein results in increased hydroxylation of HIF1A protein]
[Clioquinol co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HIF1A protein; HIF1A protein promotes the reaction [Clioquinol results in increased expression of VEGFA protein]
Clioquinol results in decreased hydroxylation of HIF1A protein
Clioquinol results in decreased ubiquitination of HIF1A protein
Clioquinol results in increased activity of HIF1A protein

PMID:16973622 PMID:19502547 PMID:19679656

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

hypoxia inducible factor 1 subunit alpha inhibitor

multiple interactions
decreases activity

Clioquinol inhibits the reaction [HIF1AN protein results in increased hydroxylation of HIF1A protein]
Clioquinol results in decreased activity of HIF1AN protein

NCBI chr 1:243,419,175...243,440,464
Ensembl chr 1:243,419,194...243,434,327

G

hypoxia inducible factor 3 subunit alpha

decreases expression

Clioquinol results in decreased expression of HIF3A mRNA

NCBI chr 1:77,718,110...77,750,448
Ensembl chr 1:77,722,471...77,749,758

G

heme oxygenase 1

increases expression

Clioquinol results in increased expression of HMOX1 mRNA

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

heat shock protein family A (Hsp70) member 5

decreases expression

Clioquinol results in decreased expression of HSPA5 mRNA

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

integrin subunit alpha 2

multiple interactions

ITGA2 protein promotes the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of EGFR protein]

NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:46,523,948...46,621,481

G

integrin subunit alpha 5

multiple interactions

ITGA5 protein promotes the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of EGFR protein]

NCBI chr 7:134,478,963...134,502,837
Ensembl chr 7:134,478,968...134,502,837

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions

Clioquinol promotes the reaction [JUN protein binds to CXCL8 promoter]

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

lysyl oxidase

increases expression
decreases secretion

Clioquinol results in increased expression of LOX mRNA
Clioquinol results in decreased secretion of LOX protein

NCBI chr18:45,964,544...45,977,431
Ensembl chr18:45,967,343...46,041,477

G

microtubule-associated protein 1 light chain 3 alpha

increases expression

Clioquinol results in increased expression of MAP1LC3A protein

NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670

G

mitogen activated protein kinase 1

multiple interactions

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Clioquinol co-treated with Copper] results in increased phosphorylation of MAPK1 protein]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of MAPK1 protein]; [4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline results in decreased phosphorylation of and results in decreased activity of EGFR protein] inhibits the reaction [[Copper binds to Clioquinol] which results in increased phosphorylation of MAPK1 protein]; [Clioquinol binds to Copper] which results in increased phosphorylation of MAPK1 protein; [Clioquinol co-treated with Copper] results in increased phosphorylation of MAPK1 protein; [Clioquinol co-treated with Zinc] results in increased phosphorylation of MAPK1 protein; AG 1879 inhibits the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]

PMID:16648635 PMID:18346929

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of MAPK3 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Clioquinol co-treated with Copper] results in increased phosphorylation of MAPK3 protein]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of MAPK3 protein]; [4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline results in decreased phosphorylation of and results in decreased activity of EGFR protein] inhibits the reaction [[Copper binds to Clioquinol] which results in increased phosphorylation of MAPK3 protein]; [Clioquinol binds to Copper] which results in increased phosphorylation of MAPK3 protein; [Clioquinol co-treated with Copper] results in increased phosphorylation of MAPK3 protein; [Clioquinol co-treated with Zinc] results in increased phosphorylation of MAPK3 protein; AG 1879 inhibits the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]

PMID:16648635 PMID:18346929

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

multiple interactions

[Clioquinol co-treated with Copper] results in increased phosphorylation of MAPK8 protein; [Clioquinol co-treated with Zinc] results in increased phosphorylation of MAPK8 protein; pyrazolanthrone inhibits the reaction [[Clioquinol co-treated with Copper] results in increased phosphorylation of MAPK8 protein]

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

macrophage migration inhibitory factor

increases expression

Clioquinol results in increased expression of MIF mRNA

NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504
Ensembl chr 4:12,790,902...12,799,504

G

microRNA 130a

multiple interactions

[Clioquinol co-treated with zinc chloride] results in decreased expression of MIR130A mRNA

NCBI chr 3:69,822,542...69,822,629
Ensembl chr 3:69,822,542...69,822,629

G

microRNA 223

multiple interactions

[Clioquinol co-treated with zinc chloride] results in decreased expression of MIR223 mRNA

NCBI chr X:61,141,887...61,141,996
Ensembl chr X:61,141,887...61,141,996

G

microRNA 29a

multiple interactions

[Clioquinol co-treated with zinc chloride] results in decreased expression of MIR29A mRNA

NCBI chr 4:59,650,608...59,650,695

G

matrix metallopeptidase 2

multiple interactions

[Clioquinol co-treated with Copper] results in increased expression of and results in increased activity of MMP2 protein

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 3

multiple interactions

[Clioquinol co-treated with Copper] results in increased expression of and results in increased activity of MMP3 protein

NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961

G

matrix metallopeptidase 9

multiple interactions

Clioquinol inhibits the reaction [MOG protein results in increased activity of MMP9 protein]

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

myelin oligodendrocyte glycoprotein

multiple interactions

Clioquinol inhibits the reaction [MOG protein results in increased activity of MMP9 protein]

NCBI chr20:1,513,137...1,523,473
Ensembl chr20:1,513,239...1,523,474

G

nerve growth factor

multiple interactions

Clioquinol inhibits the reaction [NGF protein results in increased phosphorylation of NTRK1 protein]; trichostatin A inhibits the reaction [Clioquinol inhibits the reaction [NGF protein results in increased phosphorylation of NTRK1 protein]]

NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452

G

neurotrophic receptor tyrosine kinase 1

multiple interactions

Clioquinol inhibits the reaction [NGF protein results in increased phosphorylation of NTRK1 protein]; trichostatin A inhibits the reaction [Clioquinol inhibits the reaction [NGF protein results in increased phosphorylation of NTRK1 protein]]

NCBI chr 2:173,236,961...173,253,806
Ensembl chr 2:173,236,963...173,253,770

G

prolyl 4-hydroxylase subunit alpha 2

decreases expression

Clioquinol results in decreased expression of P4HA2 mRNA

NCBI chr10:38,243,136...38,271,983
Ensembl chr10:38,243,139...38,287,314

G

phosphoglycerate kinase 1

increases expression

Clioquinol results in increased expression of PGK1 mRNA

NCBI chr X:71,271,454...71,287,429
Ensembl chr X:71,271,440...71,287,418

G

sequestosome 1

decreases expression

Clioquinol results in decreased expression of SQSTM1 protein

NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673

G

SRC proto-oncogene, non-receptor tyrosine kinase

multiple interactions

[[Clioquinol binds to Copper] which results in increased activity of SRC protein] which results in increased phosphorylation of and results in increased activity of EGFR protein; [Clioquinol binds to Copper] which results in increased phosphorylation of and results in increased activity of SRC protein

NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476

G

tumor protein p53

multiple interactions
increases phosphorylation

2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Clioquinol results in increased phosphorylation of TP53 protein]

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

vascular endothelial growth factor A

increases expression
decreases expression
multiple interactions

Clioquinol results in increased expression of VEGFA mRNA; Clioquinol results in increased expression of VEGFA protein
Clioquinol results in decreased expression of VEGFA mRNA
HIF1A protein promotes the reaction [Clioquinol results in increased expression of VEGFA protein]

PMID:16973622 PMID:19502547

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

VOPP1 WW domain binding protein

decreases expression

Clioquinol results in decreased expression of ECOP mRNA

NCBI chr 4:87,363,678...87,432,747
Ensembl chr 4:87,363,477...87,450,375

G

X-box binding protein 1

multiple interactions

Clioquinol affects the splicing of and results in decreased expression of XBP1 mRNA alternative form

NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693

D-penicillamine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensin converting enzyme 2

increases expression

Penicillamine results in increased expression of ACE2 mRNA

NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977

G

adenosylhomocysteinase

increases activity
multiple interactions

Penicillamine results in increased activity of AHCY protein
Penicillamine promotes the reaction [ATP7B protein mutant form results in decreased expression of AHCY protein]

NCBI chr 3:143,569,134...143,584,359
Ensembl chr 3:143,569,094...143,584,393

G

arachidonate 12-lipoxygenase, 12S type

increases expression
decreases expression

Penicillamine results in increased expression of ALOX12 mRNA
Penicillamine results in decreased expression of ALOX12 mRNA

NCBI chr10:54,958,263...54,970,542
Ensembl chr10:54,958,271...54,970,542

G

arachidonate 5-lipoxygenase activating protein

increases expression

Penicillamine results in increased expression of ALOX5AP mRNA

NCBI chr12:5,748,941...5,772,986
Ensembl chr12:5,748,944...5,772,986

G

annexin A1

decreases expression
increases expression

Penicillamine results in decreased expression of ANXA1 mRNA
Penicillamine results in increased expression of ANXA1 mRNA

NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343

G

annexin A4

increases expression
decreases expression

Penicillamine results in increased expression of ANXA4 mRNA
Penicillamine results in decreased expression of ANXA4 mRNA

NCBI chr 4:119,184,378...119,241,183
Ensembl chr 4:119,184,374...119,241,161

G

amyloid beta precursor protein

multiple interactions
increases metabolic processing

Penicillamine inhibits the reaction [[[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of Phosphatidylcholines] which results in increased chemical synthesis of phosphatidylcholine hydroperoxide]; Penicillamine inhibits the reaction [APP protein results in increased activity of CASP3 protein]
Penicillamine results in increased metabolism of APP protein

PMID:10940226 PMID:12963085 PMID:17964426

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

activating transcription factor 6

multiple interactions

Penicillamine results in increased metabolism of and results in increased activity of ATF6 protein

NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177

G

ATPase copper transporting alpha

multiple interactions

[Penicillamine co-treated with bathocuproine sulfonate] promotes the reaction [CLU protein binds to ATP7A protein]

NCBI chr X:71,094,144...71,201,550
Ensembl chr X:71,094,202...71,198,354

G

ATPase copper transporting beta

multiple interactions

[Penicillamine co-treated with ATP7B gene mutant form] results in decreased activity of CAT protein; [Penicillamine co-treated with bathocuproine sulfonate] promotes the reaction [CLU protein binds to ATP7B protein]; Penicillamine inhibits the reaction [ATP7B gene mutant form results in decreased abundance of Copper]; Penicillamine inhibits the reaction [ATP7B gene mutant form results in decreased abundance of Glutathione]; Penicillamine inhibits the reaction [ATP7B gene mutant form results in decreased expression of CP protein]
Penicillamine inhibits the reaction [ATP7B protein mutant form results in increased abundance of Copper]; Penicillamine inhibits the reaction [ATP7B protein mutant form results in increased expression of TNF mRNA]; Penicillamine promotes the reaction [ATP7B protein mutant form results in decreased expression of AHCY protein]; Penicillamine promotes the reaction [ATP7B protein mutant form results in decreased expression of CPT1A protein]; Penicillamine promotes the reaction [ATP7B protein mutant form results in decreased expression of DNMT3B mRNA]; Penicillamine promotes the reaction [ATP7B protein mutant form results in decreased expression of HSPA5 protein]; Penicillamine promotes the reaction [ATP7B protein mutant form results in decreased expression of PPARA mRNA]; Penicillamine promotes the reaction [ATP7B protein mutant form results in decreased expression of SREBF1 mRNA]

PMID:21242307 PMID:22945834 PMID:24368744

NCBI chr16:69,952,286...70,024,404
Ensembl chr16:69,951,778...70,023,636

G

Bcl-2 binding component 3

decreases expression

Penicillamine results in decreased expression of BBC3 protein

NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509

G

BCL2, apoptosis regulator

decreases expression

Penicillamine results in decreased expression of BCL2 mRNA; Penicillamine results in decreased expression of BCL2 protein

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

BH3 interacting domain death agonist

multiple interactions

andrographolide promotes the reaction [Penicillamine inhibits the reaction [Copper Sulfate results in decreased expression of and results in increased cleavage of BID protein]]; Penicillamine inhibits the reaction [Copper Sulfate results in decreased expression of and results in increased cleavage of BID protein]; Penicillamine promotes the reaction [andrographolide inhibits the reaction [Copper Sulfate results in decreased expression of and results in increased cleavage of BID protein]]

NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720

G

complement C1s

multiple interactions

Penicillamine inhibits the reaction [C4A protein binds to C1S protein]; Penicillamine inhibits the reaction [C4B protein binds to C1S protein]

NCBI chr 4:157,430,249...157,442,438
Ensembl chr 4:157,430,117...157,442,303

G

complement C3

increases expression

Penicillamine results in increased expression of C3 mRNA

NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429

G

complement C4A

multiple interactions

Penicillamine inhibits the reaction [C4A protein binds to C1S protein]

NCBI chr20:4,005,731...4,020,083
Ensembl chr20:4,005,731...4,020,080

G

complement C4B

multiple interactions

Penicillamine inhibits the reaction [C4B protein binds to C1S protein]

NCBI chr20:4,197,371...4,211,684
Ensembl chr20:4,197,366...4,211,681

G

caspase 3

multiple interactions
increases cleavage

andrographolide promotes the reaction [Penicillamine inhibits the reaction [Copper Sulfate results in increased cleavage of CASP3 protein]]; Penicillamine inhibits the reaction [Copper Sulfate results in increased cleavage of CASP3 protein]; Penicillamine promotes the reaction [andrographolide inhibits the reaction [Copper Sulfate results in increased cleavage of CASP3 protein]]
Penicillamine results in increased cleavage of CASP3 protein
Penicillamine inhibits the reaction [APP protein results in increased activity of CASP3 protein]

PMID:12963085 PMID:19722195 PMID:20946909 PMID:22843330

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 9

multiple interactions

andrographolide promotes the reaction [Penicillamine inhibits the reaction [Copper Sulfate results in increased activity of CASP9 protein]]; Penicillamine inhibits the reaction [Copper Sulfate results in increased activity of CASP9 protein]; Penicillamine promotes the reaction [andrographolide inhibits the reaction [Copper Sulfate results in increased activity of CASP9 protein]]

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

decreases expression
multiple interactions

Penicillamine results in decreased expression of CAT mRNA
[Penicillamine co-treated with ATP7B gene mutant form] results in decreased activity of CAT protein

PMID:22843330 PMID:24368744

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

C-C motif chemokine ligand 3

increases expression

Penicillamine results in increased expression of CCL3 mRNA

NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938

G

C-C motif chemokine ligand 4

increases expression

Penicillamine results in increased expression of CCL4 mRNA

PMID:19575532 PMID:22843330

NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231

G

C-C motif chemokine ligand 5

increases expression

Penicillamine results in increased expression of CCL5 mRNA

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

C-C motif chemokine receptor 5

increases expression
decreases expression

Penicillamine results in increased expression of CCR5 mRNA
Penicillamine results in decreased expression of CCR5 mRNA

NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260

G

CD14 molecule

decreases expression
increases expression

Penicillamine results in decreased expression of CD14 mRNA
Penicillamine results in increased expression of CD14 mRNA

NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261

G

CD163 molecule

decreases expression
increases expression

Penicillamine results in decreased expression of CD163 mRNA
Penicillamine results in increased expression of CD163 mRNA

NCBI chr 4:157,085,080...157,118,470
Ensembl chr 4:157,085,093...157,117,878

G

CD38 molecule

increases expression

Penicillamine results in increased expression of CD38 mRNA

NCBI chr14:67,172,062...67,212,328
Ensembl chr14:67,172,063...67,211,986

G

CD52 molecule

decreases expression

Penicillamine results in decreased expression of CD52 mRNA

NCBI chr 5:146,319,789...146,321,348
Ensembl chr 5:146,319,969...146,321,348

G

clusterin

multiple interactions

[Penicillamine co-treated with bathocuproine sulfonate] promotes the reaction [CLU protein binds to ATP7A protein]; [Penicillamine co-treated with bathocuproine sulfonate] promotes the reaction [CLU protein binds to ATP7B protein]

NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315

G

ceruloplasmin

decreases expression
multiple interactions

Penicillamine results in decreased expression of CP protein
Penicillamine inhibits the reaction [ATP7B gene mutant form results in decreased expression of CP protein]

PMID:24013775 PMID:24368744

NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075

G

carnitine palmitoyltransferase 1A

decreases expression
multiple interactions

Penicillamine results in decreased expression of CPT1A mRNA
Penicillamine promotes the reaction [ATP7B protein mutant form results in decreased expression of CPT1A protein]

PMID:19575532 PMID:22945834

NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055

G

C-reactive protein

decreases expression

Penicillamine results in decreased expression of CRP protein

NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178

G

colony stimulating factor 2

increases expression

Penicillamine results in increased expression of CSF2 mRNA

NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199

G

C-X-C motif chemokine receptor 4

increases expression
decreases expression

Penicillamine results in increased expression of CXCR4 mRNA
Penicillamine results in decreased expression of CXCR4 mRNA

NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression

Penicillamine results in increased expression of CYP1A1 mRNA

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 2, subfamily e, polypeptide 1

increases expression

Penicillamine results in increased expression of CYP2E1 mRNA

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

DNA-damage inducible transcript 3

increases expression

Penicillamine results in increased expression of DDIT3 mRNA; Penicillamine results in increased expression of DDIT3 protein

PMID:19722195 PMID:22843330

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

DNA methyltransferase 3 alpha

decreases expression

Penicillamine results in decreased expression of DNMT3A mRNA

NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687

G

DNA methyltransferase 3 beta

multiple interactions

Penicillamine promotes the reaction [ATP7B protein mutant form results in decreased expression of DNMT3B mRNA]

NCBI chr 3:142,130,588...142,169,128
Ensembl chr 3:142,130,592...142,169,124

G

dual specificity phosphatase 1

decreases expression

Penicillamine results in decreased expression of DUSP1 mRNA

NCBI chr10:16,680,478...16,683,275

G

dual specificity phosphatase 6

increases expression

Penicillamine results in increased expression of DUSP6 mRNA

NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185

G

early growth response 1

increases expression

Penicillamine results in increased expression of EGR1 mRNA

PMID:19575532 PMID:22843330

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

eukaryotic translation initiation factor 2 alpha kinase 3

multiple interactions

Penicillamine results in increased phosphorylation of and results in increased activity of EIF2AK3 protein

NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911

G

eukaryotic translation initiation factor 2 subunit alpha

increases phosphorylation

Penicillamine results in increased phosphorylation of EIF2S1 protein

NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225

G

elastin

affects localization

Penicillamine affects the localization of ELN protein

NCBI chr12:21,968,544...22,011,929
Ensembl chr12:21,968,544...22,011,928

G

ficolin B

increases expression

Penicillamine results in increased expression of FCNB mRNA

NCBI chr 3:11,393,713...11,402,198
Ensembl chr 3:11,393,739...11,402,151

G

flavin containing dimethylaniline monoxygenase 1

increases expression

Penicillamine results in increased expression of FMO1 mRNA

NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647

G

flavin containing dimethylaniline monoxygenase 5

increases expression

Penicillamine results in increased expression of FMO5 mRNA

NCBI chr 2:185,197,184...185,249,699
Ensembl chr 2:185,222,204...185,249,693

G

fibronectin 1

increases expression

Penicillamine results in increased expression of FN1 mRNA

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

growth arrest and DNA-damage-inducible, alpha

increases expression

Penicillamine results in increased expression of GADD45A mRNA

NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115

G

glycine amidinotransferase

increases expression

Penicillamine results in increased expression of GATM mRNA

NCBI chr 3:109,658,919...109,675,508
Ensembl chr 3:109,658,951...109,684,129

G

glutathione S-transferase, mu 5

increases expression

Penicillamine results in increased expression of GSTM3 mRNA

NCBI chr 2:195,531,599...195,534,562
Ensembl chr 2:195,531,495...195,534,553

G

heme oxygenase 1

multiple interactions
increases expression
decreases expression

[Penicillamine co-treated with bathocuproine sulfonate] results in increased expression of HMOX1 protein
Penicillamine results in increased expression of HMOX1 mRNA
Penicillamine analog results in decreased expression of HMOX1 protein

PMID:19323979 PMID:21242307 PMID:22843330

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

haptoglobin

decreases expression

Penicillamine results in decreased expression of HP protein

NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523

G

heat shock protein family A (Hsp70) member 1A

increases expression

Penicillamine results in increased expression of HSPA1A mRNA; Penicillamine results in increased expression of HSPA1A protein

NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227

G

heat shock protein family A (Hsp70) member 1 like

increases expression

Penicillamine results in increased expression of HSPA1L mRNA

NCBI chr20:3,848,843...3,855,571
Ensembl chr20:3,848,843...3,855,571

G

heat shock protein family A (Hsp70) member 2

increases expression

Penicillamine results in increased expression of HSPA2 mRNA

NCBI chr 6:95,128,504...95,131,281
Ensembl chr 6:95,128,350...95,131,287

G

heat shock protein family A (Hsp70) member 5

increases expression
multiple interactions

Penicillamine results in increased expression of HSPA5 protein
Penicillamine promotes the reaction [ATP7B protein mutant form results in decreased expression of HSPA5 protein]

PMID:19722195 PMID:22843330 PMID:22945834

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

heat shock protein family A (Hsp70) member 6 like, pseudogene 1

increases expression

Penicillamine results in increased expression of HSPA6 mRNA

NCBI chr13:83,273,176...83,274,317

G

interferon gamma

increases expression

Penicillamine results in increased expression of IFNG mRNA

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

insulin-like growth factor 1

multiple interactions

Penicillamine inhibits the reaction [IGF1 protein results in increased activity of MTR protein]

NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296

G

interleukin 10

increases expression

Penicillamine results in increased expression of IL10 mRNA

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 13

decreases expression
increases expression

Penicillamine results in decreased expression of IL13 mRNA
Penicillamine results in increased expression of IL13 mRNA

NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737

G

interleukin 15

increases expression

Penicillamine results in increased expression of IL15 mRNA

NCBI chr19:25,640,025...25,706,818
Ensembl chr19:25,640,251...25,706,820

G

interleukin 1 beta

increases expression

Penicillamine results in increased expression of IL1B mRNA

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 21

increases expression

Penicillamine results in increased expression of IL21 mRNA

NCBI chr 2:120,117,105...120,127,012
Ensembl chr 2:120,119,444...120,126,996

G

interleukin 23 subunit alpha

increases expression

Penicillamine results in increased expression of IL23A protein

NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923

G

interleukin 3 receptor subunit alpha

increases expression

Penicillamine results in increased expression of IL3RA mRNA

NCBI chr12:16,318,081...16,323,781
Ensembl chr12:16,318,081...16,323,484

G

interleukin 4

increases expression

Penicillamine results in increased expression of IL4 mRNA

PMID:9182889 PMID:21227906

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 6

increases expression

Penicillamine results in increased expression of IL6 protein

PMID:19575532 PMID:21227906

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

KLF transcription factor 4

increases expression

Penicillamine results in increased expression of KLF4 mRNA

NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602

G

galectin 1

increases expression

Penicillamine results in increased expression of LGALS1 mRNA

NCBI chr 7:110,485,239...110,488,345
Ensembl chr 7:110,481,392...110,488,345

G

lysyl oxidase-like 2

decreases activity

Penicillamine results in decreased activity of LOXL2 protein

NCBI chr15:44,683,449...44,773,067
Ensembl chr15:44,683,880...44,773,067

G

MCL1 apoptosis regulator, BCL2 family member

multiple interactions
decreases expression

PMAIP1 mutant form inhibits the reaction [Penicillamine results in decreased expression of MCL1 protein]

NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303

G

myeloperoxidase

decreases secretion
multiple interactions

Penicillamine results in decreased secretion of MPO protein
Penicillamine promotes the reaction [[MPO protein results in increased oxidation of dibromoacetonitrile] which results in increased chemical synthesis of Cyanides]; Penicillamine promotes the reaction [MPO protein results in increased oxidation of dibromoacetonitrile]

PMID:6324512 PMID:25614581

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

5-methyltetrahydrofolate-homocysteine methyltransferase

multiple interactions

Penicillamine inhibits the reaction [IGF1 protein results in increased activity of MTR protein]

NCBI chr17:58,219,998...58,308,560
Ensembl chr17:58,220,071...58,304,822

G

NFE2 like bZIP transcription factor 2

increases expression

Penicillamine results in increased expression of NFE2L2 mRNA

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

nitric oxide synthase 2

increases expression

Penicillamine results in increased expression of NOS2 mRNA

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

nuclear receptor subfamily 4, group A, member 1

increases expression

Penicillamine results in increased expression of NR4A1 mRNA

NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297

G

poly (ADP-ribose) polymerase 1

increases cleavage

Penicillamine results in increased cleavage of PARP1 protein

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

phorbol-12-myristate-13-acetate-induced protein 1

increases expression
multiple interactions

Penicillamine results in increased expression of PMAIP1 mRNA; Penicillamine results in increased expression of PMAIP1 protein
PMAIP1 mutant form inhibits the reaction [Penicillamine results in decreased expression of MCL1 protein]

NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429

G

peroxisome proliferator activated receptor alpha

multiple interactions

Penicillamine promotes the reaction [ATP7B protein mutant form results in decreased expression of PPARA mRNA]

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

G

prolactin

multiple interactions
increases expression

Danazol inhibits the reaction [Penicillamine results in increased expression of PRL]

NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062

G

prostaglandin E receptor 2

increases expression

Penicillamine results in increased expression of PTGER2 mRNA

NCBI chr15:18,215,013...18,228,714
Ensembl chr15:18,217,285...18,228,714

G

prostaglandin-endoperoxide synthase 1

increases expression

Penicillamine results in increased expression of PTGS1 mRNA

NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586

G

RT1 class I, locus CE16

affects response to substance

HLA-A gene polymorphism affects the susceptibility to Penicillamine

NCBI chr20:3,257,109...3,260,747
Ensembl chr20:3,257,123...3,279,563

G

RT1 class II, locus Db1

increases response to substance

HLA-DRB1 gene polymorphism results in increased susceptibility to Penicillamine

NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258

G

S100 calcium-binding protein A4

increases expression

Penicillamine results in increased expression of S100A4 mRNA

NCBI chr 2:176,090,951...176,093,258
Ensembl chr 2:176,091,804...176,093,254

G

S100 calcium binding protein A6

increases expression

Penicillamine results in increased expression of S100A6 mRNA

NCBI chr 2:176,100,619...176,102,181
Ensembl chr 2:176,100,899...176,102,180

G

S100 calcium binding protein A8

decreases expression
increases expression

Penicillamine results in decreased expression of S100A8 mRNA
Penicillamine results in increased expression of S100A8 mRNA

NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643

G

S100 calcium binding protein A9

decreases expression
increases expression

Penicillamine results in decreased expression of S100A9 mRNA
Penicillamine results in increased expression of S100A9 mRNA

NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230

G

selenium binding protein 1

decreases expression

Penicillamine results in decreased expression of SELENBP1 mRNA

NCBI chr 2:182,494,004...182,504,594
Ensembl chr 2:182,493,978...182,504,594

G

solute carrier family 11 member 1

increases expression

Penicillamine results in increased expression of SLC11A1 mRNA

NCBI chr 9:75,957,193...75,968,115
Ensembl chr 9:75,957,316...75,968,101

G

solute carrier family 28 member 2

decreases expression
increases expression

Penicillamine results in decreased expression of SLC28A2 mRNA
Penicillamine results in increased expression of SLC28A2 mRNA

NCBI chr 3:109,324,815...109,387,702
Ensembl chr 3:109,366,996...109,387,702

G

solute carrier family 30 member 1

decreases expression
increases expression

Penicillamine results in decreased expression of SLC30A1 mRNA
Penicillamine results in increased expression of SLC30A1 mRNA

NCBI chr13:103,491,037...103,494,910
Ensembl chr13:103,491,037...103,494,910

G

solute carrier family 31 member 1

multiple interactions
increases expression

[Penicillamine results in increased expression of SLC31A1 mRNA] which results in decreased susceptibility to Oxaliplatin; [Penicillamine results in increased expression of SLC31A1 mRNA] which results in increased susceptibility to Carboplatin; [Penicillamine results in increased expression of SLC31A1 mRNA] which results in increased susceptibility to Cisplatin; Cisplatin promotes the reaction [Penicillamine results in increased expression of SLC31A1 mRNA]; Penicillamine promotes the reaction [Cisplatin results in increased expression of SLC31A1 mRNA]

NCBI chr 5:75,814,744...75,844,241
Ensembl chr 5:75,814,743...75,844,228

G

solute carrier family 4 member 1 (Diego blood group)

decreases expression

Penicillamine results in decreased expression of SLC4A1 mRNA

NCBI chr10:87,306,865...87,323,132
Ensembl chr10:87,306,872...87,323,117

G

superoxide dismutase 1

decreases activity

Penicillamine analog results in decreased activity of SOD1 protein

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

Sp1 transcription factor

increases expression

Penicillamine results in increased expression of SP1 mRNA

NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961

G

sterol regulatory element binding transcription factor 1

multiple interactions

Penicillamine promotes the reaction [ATP7B protein mutant form results in decreased expression of SREBF1 mRNA]

NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650

G

syntaxin 3

increases expression
decreases expression

Penicillamine results in increased expression of STX3 mRNA
Penicillamine results in decreased expression of STX3 mRNA

NCBI chr 1:208,617,018...208,686,240
Ensembl chr 1:208,639,115...208,685,805

G

transferrin receptor

increases expression

Penicillamine results in increased expression of TFRC mRNA

NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257

G

tumor necrosis factor

increases expression
multiple interactions

Penicillamine results in increased expression of TNF protein
Penicillamine inhibits the reaction [ATP7B protein mutant form results in increased expression of TNF mRNA]

PMID:19575532 PMID:22945834

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

tumor protein p53

increases expression
decreases expression

Penicillamine results in increased expression of TP53 protein
Penicillamine results in decreased expression of TP53 mRNA

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

X-box binding protein 1

increases splicing

Penicillamine results in increased splicing of XBP1 mRNA

NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693

diethyldithiocarbamic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acyl-CoA oxidase 1

multiple interactions

Ditiocarb inhibits the reaction [YY1 protein inhibits the reaction [jujuboside A inhibits the reaction [Fatty Acids, Nonesterified promotes the reaction [Glucose results in decreased expression of ACOX1 protein]]]]

NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232

G

aminolevulinate dehydratase

multiple interactions
decreases activity

Ditiocarb inhibits the reaction [Ditiocarb analog results in decreased activity of ALAD protein]; Ditiocarb inhibits the reaction [lead acetate results in decreased activity of ALAD protein]

NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474

G

aldehyde dehydrogenase 3 family, member A1

increases chemical synthesis

ALDH3A1 protein results in increased chemical synthesis of Ditiocarb

NCBI chr10:45,892,993...45,902,680
Ensembl chr10:45,892,924...45,902,681

G

annexin A1

increases expression

Ditiocarb results in increased expression of ANXA1 mRNA

NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343

G

apoptotic peptidase activating factor 1

multiple interactions

[[Ditiocarb binds to Copper] which affects the localization of CYCS protein] promotes the reaction [[[CYCS protein binds to APAF1 protein binds to CASP9 protein] which results in increased metabolism of and results in increased activity of CASP9 protein] which results in increased activity of CASP3 protein]

NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540

G

amyloid beta precursor protein

multiple interactions

Ditiocarb inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of APP mRNA]; Ditiocarb inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of APP protein]

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

beta-secretase 1

multiple interactions

Ditiocarb inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of BACE1 mRNA]

NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876

G

caspase 1

multiple interactions
affects expression

[Ditiocarb co-treated with Zinc] results in decreased expression of CASP1 protein
Ditiocarb affects the expression of CASP1 protein

NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383

G

caspase 3

multiple interactions

[[Ditiocarb binds to Copper] which affects the localization of CYCS protein] promotes the reaction [[[CYCS protein binds to APAF1 protein binds to CASP9 protein] which results in increased metabolism of and results in increased activity of CASP9 protein] which results in increased activity of CASP3 protein]
[Ditiocarb co-treated with Arsenic Trioxide] results in increased activity of CASP3 protein

PMID:22951949 PMID:27592447

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

multiple interactions

[Ditiocarb binds to Copper] which results in increased activity of CASP8 protein

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

multiple interactions

[[Ditiocarb binds to Copper] which affects the localization of CYCS protein] promotes the reaction [[[CYCS protein binds to APAF1 protein binds to CASP9 protein] which results in increased metabolism of and results in increased activity of CASP9 protein] which results in increased activity of CASP3 protein]

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

decreases expression

Ditiocarb results in decreased expression of CAT mRNA

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

copper chaperone for superoxide dismutase

decreases expression

Ditiocarb results in decreased expression of CCS protein

NCBI chr 1:202,113,792...202,134,931
Ensembl chr 1:202,113,804...202,134,915

G

2',3'-cyclic nucleotide 3' phosphodiesterase

increases expression

Ditiocarb results in increased expression of CNP protein

NCBI chr10:85,511,164...85,517,723
Ensembl chr10:85,511,160...85,517,720

G

ceruloplasmin

multiple interactions

Ditiocarb inhibits the reaction [Pyruvaldehyde promotes the reaction [CP protein binds to CP protein]]

NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075

G

carnitine palmitoyltransferase 1A

multiple interactions

Ditiocarb inhibits the reaction [YY1 protein inhibits the reaction [jujuboside A inhibits the reaction [Fatty Acids, Nonesterified promotes the reaction [Glucose results in decreased expression of CPT1A protein]]]]

NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055

G

cytochrome c, somatic

multiple interactions

[[Ditiocarb binds to Copper] which affects the localization of CYCS protein] promotes the reaction [[[CYCS protein binds to APAF1 protein binds to CASP9 protein] which results in increased metabolism of and results in increased activity of CASP9 protein] which results in increased activity of CASP3 protein]; [Ditiocarb binds to Copper] which affects the localization of CYCS protein

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions

Ditiocarb inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 2, subfamily b, polypeptide 1

increases expression

Ditiocarb results in increased expression of CYP2B1 mRNA

NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052

G

cytochrome P450, family 2, subfamily b, polypeptide 2

increases expression

Ditiocarb results in increased expression of CYP2B2 mRNA

NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566

G

cytochrome P450, family 2, subfamily C, polypeptide 6

decreases activity

Ditiocarb results in decreased activity of CYP2C19 protein

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 2, subfamily e, polypeptide 1

decreases activity
multiple interactions

Ditiocarb results in decreased activity of CYP2E1 protein
Ditiocarb inhibits the reaction [CYP2E1 protein results in increased glutathionylation of Lamotrigine]; Ditiocarb inhibits the reaction [CYP2E1 protein results in increased metabolism of 2-xylene]; Ditiocarb inhibits the reaction [CYP2E1 protein results in increased metabolism of 3-xylene]; Ditiocarb inhibits the reaction [CYP2E1 protein results in increased metabolism of 4-xylene]; Ditiocarb inhibits the reaction [CYP2E1 protein results in increased metabolism of Theobromine]; Ditiocarb inhibits the reaction [CYP2E1 protein results in increased metabolism of Toluene]; Ditiocarb inhibits the reaction [CYP2E1 protein results in increased susceptibility to [ferric nitrilotriacetate co-treated with Arachidonic Acid]]
[Ditiocarb co-treated with CYP2E1 gene mutant form] results in decreased metabolism of Styrene; [Ditiocarb results in decreased activity of CYP2E1 protein] which results in decreased oxidation of Benzene
Ditiocarb inhibits the reaction [[Benzene results in increased expression of CYP2E1 protein] which results in increased metabolism of Benzene]; Ditiocarb inhibits the reaction [CYP2E1 protein results in increased hydroxylation of 4-nitrophenol]; Ditiocarb inhibits the reaction [CYP2E1 protein results in increased metabolism of methylformamide]; Ditiocarb inhibits the reaction [pyridine results in increased activity of CYP2E1 protein]

PMID:1356728 PMID:1538706 PMID:1664256 PMID:8558417 PMID:8560479 More...

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

DNA-damage-inducible transcript 4

increases expression

Ditiocarb results in increased expression of DDIT4 protein

NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105

G

dihydropyrimidinase-like 2

increases expression

Ditiocarb results in increased expression of DPYSL2 protein

NCBI chr15:41,005,551...41,111,724
Ensembl chr15:41,005,551...41,111,829

G

glutamic--pyruvic transaminase

multiple interactions

Ditiocarb inhibits the reaction [YY1 protein inhibits the reaction [jujuboside A inhibits the reaction [Fatty Acids, Nonesterified promotes the reaction [Glucose results in increased expression of GPT protein]]]]

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

glutathione S-transferase alpha 3

multiple interactions

Ditiocarb binds to and results in decreased activity of GSTA3 protein

NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240

G

glutathione S-transferase mu 1

multiple interactions

Ditiocarb binds to and results in decreased activity of GSTM1 protein

NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411

G

glutathione S-transferase pi 1

increases expression

Ditiocarb results in increased expression of GSTP1 protein

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha

decreases expression

Ditiocarb results in decreased expression of HADHA protein

NCBI chr 6:26,187,969...26,227,605
Ensembl chr 6:26,187,956...26,227,869

G

heme oxygenase 1

increases expression

Ditiocarb results in increased expression of HMOX1 protein

PMID:19467251 PMID:20452388 PMID:22874009

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

hydroxysteroid 11-beta dehydrogenase 2

decreases activity

Ditiocarb results in decreased activity of HSD11B2 protein

NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899

G

intercellular adhesion molecule 1

multiple interactions

[[Paraquat co-treated with Ditiocarb] results in decreased activity of SOD1 protein] which results in increased expression of ICAM1 protein

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

interferon gamma

increases expression
multiple interactions

Ditiocarb results in increased expression of IFNG protein
Ditiocarb inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of APP mRNA]; Ditiocarb inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of APP protein]; Ditiocarb inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of BACE1 mRNA]; Ditiocarb inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Ditiocarb inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PSEN1 mRNA]; Ditiocarb inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PSEN2 mRNA]; Ditiocarb inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased secretion of Nitric Oxide]
Ditiocarb inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased metabolism of Nitric Oxide]; Polysaccharides inhibits the reaction [Ditiocarb results in increased expression of IFNG protein]

PMID:11498278 PMID:26826268 PMID:28242320

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

interleukin 1 beta

multiple interactions
increases expression

Polysaccharides inhibits the reaction [Ditiocarb results in increased expression of IL1B protein]
Ditiocarb inhibits the reaction [YY1 protein inhibits the reaction [jujuboside A inhibits the reaction [[Fatty Acids, Nonesterified co-treated with Glucose] results in increased expression of IL1B protein]]]

PMID:26826268 PMID:39059604

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions

Ditiocarb inhibits the reaction [YY1 protein inhibits the reaction [jujuboside A inhibits the reaction [[Fatty Acids, Nonesterified co-treated with Glucose] results in increased expression of IL6 protein]]]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

mitogen activated protein kinase 1

increases phosphorylation
multiple interactions

Ditiocarb results in increased phosphorylation of MAPK1 protein
Acetylcysteine inhibits the reaction [Ditiocarb results in increased phosphorylation of MAPK1 protein]; Nitric Oxide affects the reaction [Ditiocarb results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Ditiocarb results in increased phosphorylation of MAPK1 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

increases phosphorylation
multiple interactions

Ditiocarb results in increased phosphorylation of MAPK3 protein
Acetylcysteine inhibits the reaction [Ditiocarb results in increased phosphorylation of MAPK3 protein]; Nitric Oxide affects the reaction [Ditiocarb results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Ditiocarb results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

myelin basic protein

increases expression

Ditiocarb results in increased expression of MBP protein

NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404

G

nuclear factor kappa B subunit 1

multiple interactions

Ditiocarb inhibits the reaction [Isoflurane affects the localization of NFKB1 protein]

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

NLR family, pyrin domain containing 3

affects expression
multiple interactions

Ditiocarb affects the expression of NLRP3 protein
[Ditiocarb co-treated with Zinc] results in decreased expression of NLRP3 protein

NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811

G

nitric oxide synthase 2

multiple interactions

Ditiocarb inhibits the reaction [Isoflurane results in increased expression of NOS2 protein]
Ditiocarb inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]

PMID:18708911 PMID:28242320

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

phospholipase A2 group 4A

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [Ditiocarb results in increased expression of PLA2G4A mRNA]; Nitric Oxide affects the reaction [Ditiocarb results in increased expression of PLA2G4A mRNA]; Nitric Oxide affects the reaction [Ditiocarb results in increased expression of PLA2G4A protein]; U 0126 inhibits the reaction [Ditiocarb results in increased expression of PLA2G4A mRNA]; U 0126 inhibits the reaction [Ditiocarb results in increased expression of PLA2G4A protein]
Ditiocarb results in increased expression of PLA2G4A mRNA; Ditiocarb results in increased expression of PLA2G4A protein

NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266

G

phospholamban

multiple interactions
increases phosphorylation

1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Ditiocarb results in increased phosphorylation of PLN protein]

NCBI chr20:32,629,537...32,639,559

G

peroxisome proliferator activated receptor alpha

multiple interactions

Ditiocarb inhibits the reaction [YY1 protein inhibits the reaction [jujuboside A inhibits the reaction [[Glucose co-treated with Fatty Acids, Nonesterified] results in decreased expression of PPARA protein]]]

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

G

peroxiredoxin 2

increases expression

Ditiocarb results in increased expression of PRDX2 protein

NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194

G

peroxiredoxin 6

increases expression

Ditiocarb results in increased expression of PRDX6 protein

NCBI chr13:73,528,746...73,539,295
Ensembl chr13:73,528,210...73,539,355

G

prion protein

increases expression

Ditiocarb results in increased expression of PRNP protein

NCBI chr 3:119,186,073...119,201,513
Ensembl chr 3:119,177,485...119,203,937

G

presenilin 1

multiple interactions

Ditiocarb inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PSEN1 mRNA]

NCBI chr 6:103,323,052...103,375,088
Ensembl chr 6:103,323,120...103,371,650

G

presenilin 2

multiple interactions

Ditiocarb inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PSEN2 mRNA]

NCBI chr13:91,967,506...91,993,240
Ensembl chr13:91,967,983...91,993,174

G

glycogen phosphorylase B

increases expression

Ditiocarb results in increased expression of PYGB protein

NCBI chr 3:139,611,724...139,658,521
Ensembl chr 3:139,611,749...139,663,553

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

Ditiocarb inhibits the reaction [Isoflurane affects the localization of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

solute carrier family 6 member 3

increases expression

Ditiocarb results in increased expression of SLC6A3 protein

NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413

G

synuclein alpha

increases expression

Ditiocarb results in increased expression of SNCA protein

NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262

G

superoxide dismutase 1

multiple interactions
increases expression
decreases activity

[[Paraquat co-treated with Ditiocarb] results in decreased activity of SOD1 protein] which results in increased expression of ICAM1 protein
Ditiocarb results in increased expression of SOD1 protein
Ditiocarb results in increased expression of SOD1 mRNA
Ditiocarb inhibits the reaction [lactacystin affects the localization of SOD1 protein mutant form]
Ditiocarb results in decreased activity of SOD1 protein; Ditiocarb results in decreased activity of SOD1 protein mutant form

PMID:8279580 PMID:10644010 PMID:15034941 PMID:16681429 PMID:19467251 More...

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

tyrosine hydroxylase

multiple interactions

Ditiocarb results in decreased expression of and results in increased phosphorylation of TH protein

NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767

G

tumor necrosis factor

multiple interactions

Ditiocarb inhibits the reaction [Asbestos, Crocidolite results in increased secretion of TNF protein]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

tumor protein p53

increases expression
multiple interactions

Ditiocarb results in increased expression of TP53 protein
Ditiocarb inhibits the reaction [cobaltous chloride results in increased expression of and results in increased activity of TP53 protein]; Ditiocarb inhibits the reaction [Oxygen deficiency results in increased expression of TP53 protein]

PMID:10951577 PMID:11964141

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

ubiquitin-like modifier activating enzyme 1

multiple interactions

Ditiocarb results in decreased activity of and results in decreased ubiquitination of UBA1 protein
Ditiocarb binds to and results in decreased activity of UBA1 protein

PMID:22874009 PMID:25714994

NCBI chr X:1,508,700...1,530,677
Ensembl chr X:1,508,666...1,530,636

G

uncoupling protein 2

increases expression

Ditiocarb results in increased expression of UCP2 protein

NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611

G

YY1 transcription factor

multiple interactions

Ditiocarb inhibits the reaction [YY1 protein inhibits the reaction [jujuboside A inhibits the reaction [[Fatty Acids, Nonesterified co-treated with Glucose] results in increased expression of IL1B protein]]]; Ditiocarb inhibits the reaction [YY1 protein inhibits the reaction [jujuboside A inhibits the reaction [[Fatty Acids, Nonesterified co-treated with Glucose] results in increased expression of IL6 protein]]]; Ditiocarb inhibits the reaction [YY1 protein inhibits the reaction [jujuboside A inhibits the reaction [[Glucose co-treated with Fatty Acids, Nonesterified] results in decreased expression of PPARA protein]]]; Ditiocarb inhibits the reaction [YY1 protein inhibits the reaction [jujuboside A inhibits the reaction [Fatty Acids, Nonesterified promotes the reaction [Glucose results in decreased expression of ACOX1 protein]]]]; Ditiocarb inhibits the reaction [YY1 protein inhibits the reaction [jujuboside A inhibits the reaction [Fatty Acids, Nonesterified promotes the reaction [Glucose results in decreased expression of CPT1A protein]]]]; Ditiocarb inhibits the reaction [YY1 protein inhibits the reaction [jujuboside A inhibits the reaction [Fatty Acids, Nonesterified promotes the reaction [Glucose results in increased expression of GPT protein]]]]

NCBI chr 6:127,706,739...127,736,499
Ensembl chr 6:127,707,596...127,732,747

ethylenediaminetetraacetic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensin I converting enzyme

decreases activity
multiple interactions

Edetic Acid results in decreased activity of ACE protein
Zinc Sulfate inhibits the reaction [Edetic Acid results in decreased activity of ACE protein]

NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131

G

acetylcholinesterase

multiple interactions

Edetic Acid results in decreased metabolism of and results in decreased secretion of ACHE protein

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

aryl hydrocarbon receptor

multiple interactions

Edetic Acid inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 enhancer]]

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

alanyl aminopeptidase, membrane

multiple interactions

Edetic Acid promotes the reaction [1,10-phenanthroline results in decreased activity of ANPEP protein]

NCBI chr 1:133,767,332...133,810,137
Ensembl chr 1:133,767,332...133,785,789

G

amyloid beta precursor like protein 1

multiple interactions

Edetic Acid inhibits the reaction [Zinc affects the localization of APLP1 protein]

NCBI chr 1:85,696,880...85,707,215
Ensembl chr 1:85,696,882...85,707,155

G

amyloid beta precursor like protein 2

multiple interactions

Edetic Acid inhibits the reaction [Zinc affects the localization of APLP2 protein]

NCBI chr 8:29,599,230...29,662,311
Ensembl chr 8:29,599,230...29,661,855

G

amyloid beta precursor protein

multiple interactions

Edetic Acid inhibits the reaction [[[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of phosphatidylcholine hydroperoxide] which results in increased chemical synthesis of 4-hydroxy-2-nonenal]; Edetic Acid inhibits the reaction [[[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of Phosphatidylcholines] which results in increased chemical synthesis of phosphatidylcholine hydroperoxide]

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

aspartoacylase

decreases activity

Edetic Acid results in decreased activity of ASPA protein

NCBI chr10:57,891,704...57,945,267
Ensembl chr10:57,892,104...57,945,272

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1

multiple interactions

[ferrous sulfate co-treated with Edetic Acid] results in decreased activity of ATP2A1 protein; Butylated Hydroxytoluene inhibits the reaction [[ferrous sulfate co-treated with Edetic Acid] results in decreased activity of ATP2A1 protein]; dicarbine inhibits the reaction [[ferrous sulfate co-treated with Edetic Acid] results in decreased activity of ATP2A1 protein]

NCBI chr 1:181,026,606...181,044,859
Ensembl chr 1:181,026,608...181,044,838

G

bone morphogenetic protein 4

multiple interactions

[Edetic Acid inhibits the reaction [Calcium binds to MGP protein]] inhibits the reaction [MGP protein binds to BMP4 protein]

NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306

G

caspase 1

multiple interactions

Edetic Acid inhibits the reaction [Ziram results in decreased expression of and results in increased degradation of CASP1 protein]

NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383

G

catalase

multiple interactions

CAT inhibits the reaction [[XDH protein co-treated with Edetic Acid analog] results in increased oxidation of Uroporphyrinogens]

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

ceruloplasmin

multiple interactions

Edetic Acid inhibits the reaction [CP protein results in increased oxidation of 3-carboxy-2,2,5,5-tetramethylpyrrolidin-1-yloxyl]

NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions

Edetic Acid inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 enhancer]]

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions

Edetic Acid inhibits the reaction [Cycloheximide results in increased degradation of CYP2E1 protein]

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

dihydrolipoamide dehydrogenase

multiple interactions

Edetic Acid inhibits the reaction [Cadmium Chloride results in decreased activity of and results in increased phosphorylation of DLD protein]

NCBI chr 6:47,904,153...47,924,814
Ensembl chr 6:47,903,914...47,924,795

G

dentin sialophosphoprotein

affects localization

Edetic Acid affects the localization of DSPP protein

NCBI chr14:5,565,562...5,571,669
Ensembl chr14:5,565,629...5,571,672

G

dual specificity phosphatase 23

multiple interactions

Edetic Acid inhibits the reaction [DUSP23 protein results in decreased phosphorylation of nitrophenylphosphate]

NCBI chr13:85,097,899...85,100,054
Ensembl chr13:85,097,899...85,100,093

G

ectonucleotide pyrophosphatase/phosphodiesterase 7

multiple interactions

Edetic Acid inhibits the reaction [Zinc results in decreased activity of ENPP7 protein]

NCBI chr10:104,242,169...104,247,185
Ensembl chr10:104,242,223...104,246,589

G

estrogen receptor 1

increases expression

Edetic Acid results in increased expression of ESR1 mRNA

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

growth hormone 1

multiple interactions

Edetic Acid promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]

NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078

G

insulin-like growth factor binding protein 5

decreases degradation

Edetic Acid results in decreased degradation of IGFBP5 protein

NCBI chr 9:74,452,371...74,464,953
Ensembl chr 9:74,448,382...74,465,156

G

interleukin 6

multiple interactions

Edetic Acid inhibits the reaction [Calcium promotes the reaction [Histamine results in increased expression of IL6 protein]]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

integrin subunit alpha M

increases expression

Edetic Acid results in increased expression of ITGAM protein

NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503

G

Kelch-like ECH-associated protein 1

multiple interactions

Edetic Acid promotes the reaction [dexamethasone 21-methanesulfonate binds to KEAP1 protein]

NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862

G

myelin basic protein

affects expression

Edetic Acid affects the expression of MBP mRNA

NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404

G

matrix Gla protein

multiple interactions

[Edetic Acid inhibits the reaction [Calcium binds to MGP protein]] inhibits the reaction [MGP protein binds to BMP4 protein]; Edetic Acid inhibits the reaction [Calcium binds to MGP protein]

NCBI chr 4:169,766,290...169,769,612
Ensembl chr 4:169,766,279...169,769,667

G

matrix metallopeptidase 8

decreases activity

Edetic Acid results in decreased activity of MMP8 protein

NCBI chr 8:4,724,009...4,733,864
Ensembl chr 8:4,724,029...4,733,520

G

metallothionein 1

multiple interactions

Edetic Acid inhibits the reaction [2-tert-butylhydroquinone results in increased expression of MT1 mRNA]; Edetic Acid inhibits the reaction [zinc chloride promotes the reaction [2-tert-butylhydroquinone results in increased expression of MT1 mRNA]]

NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049
Ensembl chr X:10,826,032...10,827,049

G

metallothionein 3

increases alkylation
affects metabolic processing

Edetic Acid results in increased alkylation of MT3 protein
MT3 protein polymorphism affects the metabolism of Edetic Acid

PMID:12383939 PMID:14983064

NCBI chr19:10,848,754...10,850,158
Ensembl chr19:10,848,755...10,850,158

G

nei-like DNA glycosylase 1

multiple interactions

[tris(2-carboxyethyl)phosphine co-treated with Edetic Acid] inhibits the reaction [Copper results in decreased activity of NEIL1 protein]; Edetic Acid inhibits the reaction [Iron binds to and results in decreased activity of NEIL1 protein]

NCBI chr 8:57,550,142...57,556,884
Ensembl chr 8:57,550,147...57,556,258

G

opticin

multiple interactions

Edetic Acid inhibits the reaction [Oxygen deficiency results in increased degradation of OPTC protein]; Edetic Acid inhibits the reaction [VEGFA protein results in increased degradation of OPTC protein]

NCBI chr13:45,353,954...45,368,254
Ensembl chr13:45,355,148...45,365,237

G

phosphoglycolate phosphatase

decreases activity

Edetic Acid results in decreased activity of PGP protein

NCBI chr10:13,495,232...13,497,858
Ensembl chr10:13,494,291...13,497,858

G

plasminogen activator, tissue type

multiple interactions

Edetic Acid inhibits the reaction [Zinc results in increased expression of PLAT mRNA]; Edetic Acid inhibits the reaction [Zinc results in increased expression of PLAT protein]; Edetic Acid inhibits the reaction [Zinc results in increased secretion of PLAT protein]

NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223

G

plasminogen

multiple interactions

Edetic Acid inhibits the reaction [Zinc results in increased expression of PLG mRNA]; Edetic Acid inhibits the reaction [Zinc results in increased expression of PLG protein]

NCBI chr 1:48,325,186...48,367,643
Ensembl chr 1:48,325,185...48,367,786

G

prolactin

multiple interactions

Edetic Acid inhibits the reaction [PRL protein binds to PRLR protein]

NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062

G

prolactin receptor

multiple interactions

Edetic Acid inhibits the reaction [PRL protein binds to PRLR protein]

NCBI chr 2:59,134,147...59,324,719
Ensembl chr 2:59,134,588...59,324,718

G

prion protein

multiple interactions

Edetic Acid inhibits the reaction [[Hydrogen Peroxide co-treated with Copper] results in increased cleavage of PRNP protein]; Edetic Acid inhibits the reaction [[Hydrogen Peroxide co-treated with Iron] results in increased cleavage of PRNP protein]

NCBI chr 3:119,186,073...119,201,513
Ensembl chr 3:119,177,485...119,203,937

G

S100 calcium binding protein A2

multiple interactions

Edetic Acid inhibits the reaction [Copper promotes the reaction [S100A2 protein binds to S100A2 protein]]; Edetic Acid inhibits the reaction [S100A2 protein binds to S100A2 protein]

NCBI chr 2:176,077,081...176,078,325

G

S100 calcium-binding protein A4

multiple interactions

Edetic Acid inhibits the reaction [Copper promotes the reaction [S100A4 protein binds to S100A4 protein]]

NCBI chr 2:176,090,951...176,093,258
Ensembl chr 2:176,091,804...176,093,254

G

selectin L

decreases expression

Edetic Acid results in decreased expression of SELL protein

NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456

G

solute carrier family 30, member 10

increases expression
multiple interactions

Edetic Acid results in increased expression of SLC30A10 mRNA; Edetic Acid results in increased expression of SLC30A10 protein
Edetic Acid inhibits the reaction [SLC30A10 gene mutant form results in increased abundance of Manganese]

PMID:22341971 PMID:22926781

NCBI chr13:96,998,143...97,048,076
Ensembl chr13:96,998,143...97,009,103

G

spectrin, alpha, non-erythrocytic 1

multiple interactions

Edetic Acid inhibits the reaction [Calcium results in increased cleavage of SPTAN1 protein]

NCBI chr 3:13,241,164...13,306,047
Ensembl chr 3:13,241,217...13,306,046

G

serine racemase

multiple interactions

Adenosine Triphosphate inhibits the reaction [Edetic Acid inhibits the reaction [SRR protein results in increased abundance of D-Aspartic Acid]]; Edetic Acid inhibits the reaction [SRR protein results in increased abundance of D-Aspartic Acid]

NCBI chr10:59,769,563...59,786,688
Ensembl chr10:59,769,571...59,787,011

G

tumor necrosis factor

increases expression

Edetic Acid results in increased expression of TNF protein

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

tumor protein p53

multiple interactions

Edetic Acid inhibits the reaction [[Cadmium Chloride results in decreased activity of TP53 protein] inhibits the reaction [TP53 protein binds to TP53 gene]]; Edetic Acid inhibits the reaction [[Cadmium Chloride results in decreased activity of TP63 protein] inhibits the reaction [TP63 protein binds to TP53 gene]]; Edetic Acid inhibits the reaction [[Cadmium Chloride results in decreased activity of TP73 protein] inhibits the reaction [TP73 protein binds to TP53 gene]]

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

tumor protein p63

multiple interactions

Edetic Acid inhibits the reaction [[Cadmium Chloride results in decreased activity of TP63 protein] inhibits the reaction [TP63 protein binds to TP53 gene]]

NCBI chr11:74,838,858...75,049,764
Ensembl chr11:74,838,859...75,049,398

G

tumor protein p73

multiple interactions

Edetic Acid inhibits the reaction [[Cadmium Chloride results in decreased activity of TP73 protein] inhibits the reaction [TP73 protein binds to TP53 gene]]

NCBI chr 5:164,621,377...164,703,958
Ensembl chr 5:164,621,377...164,681,128

G

transient receptor potential cation channel, subfamily V, member 1

multiple interactions

Edetic Acid inhibits the reaction [Capsaicin promotes the reaction [TRPV1 protein results in increased uptake of Calcium]]

NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513

G

thioredoxin reductase 1

increases activity
multiple interactions

Edetic Acid results in increased activity of TXNRD1 protein
Zinc inhibits the reaction [Edetic Acid results in increased activity of TXNRD1 protein]

NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863

G

thioredoxin reductase 3

increases activity
multiple interactions

Edetic Acid results in increased activity of TXNRD3 protein
Zinc inhibits the reaction [Edetic Acid results in increased activity of TXNRD3 protein]

NCBI chr 4:122,072,548...122,112,493
Ensembl chr 4:122,072,548...122,112,491

G

vascular endothelial growth factor A

multiple interactions

Edetic Acid inhibits the reaction [VEGFA protein results in increased degradation of OPTC protein]

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

xanthine dehydrogenase

multiple interactions

[XDH protein co-treated with Edetic Acid analog] results in increased oxidation of Uroporphyrinogens; CAT inhibits the reaction [[XDH protein co-treated with Edetic Acid analog] results in increased oxidation of Uroporphyrinogens]

NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alanyl-tRNA synthetase 1

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of AARS1 mRNA

NCBI chr19:38,999,130...39,021,152
Ensembl chr19:38,999,163...39,021,147

G

ATP binding cassette subfamily C member 10

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of ABCC10 mRNA

NCBI chr 9:14,657,242...14,677,178
Ensembl chr 9:14,657,264...14,677,178

G

ATP binding cassette subfamily C member 9

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of ABCC9 mRNA

NCBI chr 4:175,531,854...175,655,849
Ensembl chr 4:175,532,547...175,655,356

G

ABL proto-oncogene 1, non-receptor tyrosine kinase

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of ABL1 mRNA

NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065

G

acyl-CoA dehydrogenase, long chain

decreases expression
multiple interactions

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of ACADL protein
Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of ACADL protein]

NCBI chr 9:68,333,981...68,372,149
Ensembl chr 9:68,333,980...68,372,220

G

angiotensinogen

multiple interactions

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [AGT protein results in decreased expression of CAT protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [AGT protein results in increased abundance of Reactive Oxygen Species]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [AGT protein results in increased localization of Zinc]

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

apoptosis inducing factor, mitochondria associated 1

multiple interactions

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [[Zinc Sulfate co-treated with prolinedithiocarbamate] affects the localization of AIFM1 protein]

NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256

G

alkaline phosphatase, biomineralization associated

multiple interactions

[zinc chloride deficiency co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in decreased expression of ALPL mRNA

NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446

G

adaptor related protein complex 2 subunit beta 1

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of AP2B1 mRNA

NCBI chr10:68,099,397...68,205,023
Ensembl chr10:68,099,547...68,205,013

G

APC regulator of WNT signaling pathway 2

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of APC2 mRNA

NCBI chr 7:9,392,336...9,414,364
Ensembl chr 7:9,392,336...9,414,310

G

apolipoprotein B

decreases expression
multiple interactions

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of APOB protein
Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of APOB protein]

NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497

G

Rho/Rac guanine nucleotide exchange factor 18

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of ARHGEF18 mRNA

NCBI chr12:1,395,035...1,503,082
Ensembl chr12:1,395,088...1,503,081

G

ATM serine/threonine kinase

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of ATM mRNA

NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437

G

antizyme inhibitor 1

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of AZIN1 mRNA

NCBI chr 7:69,654,773...69,681,578
Ensembl chr 7:69,654,663...69,681,578

G

BCL2 associated X, apoptosis regulator

multiple interactions

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [SLC39A6 mutant form inhibits the reaction [trichostatin A results in increased expression of BAX protein]]; Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [SLC39A6 mutant form inhibits the reaction [trichostatin A results in increased expression of BAX protein]]]

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

Bcl-2 binding component 3

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of BBC3 mRNA

NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509

G

Bardet-Biedl syndrome 9

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of BBS9 mRNA

NCBI chr 8:21,013,865...21,437,934
Ensembl chr 8:21,013,944...21,437,930

G

BCL2, apoptosis regulator

multiple interactions
decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [SLC39A6 mutant form inhibits the reaction [trichostatin A results in decreased expression of BCL2 protein]]; Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [SLC39A6 mutant form inhibits the reaction [trichostatin A results in decreased expression of BCL2 protein]]]
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of BCL2 mRNA

PMID:19887557 PMID:33645215

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

multiple interactions

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [SLC39A6 mutant form inhibits the reaction [trichostatin A results in decreased expression of BCL2L1 protein]]; Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [SLC39A6 mutant form inhibits the reaction [trichostatin A results in decreased expression of BCL2L1 protein]]]

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479

G

bone gamma-carboxyglutamate protein

increases expression
multiple interactions

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of BGLAP protein
[zinc chloride co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in increased expression of BGLAP mRNA; [zinc chloride deficiency co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in decreased expression of BGLAP mRNA

PMID:19913120 PMID:22228435

NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495

G

BRCA2, DNA repair associated

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of BRCA2 mRNA

NCBI chr12:59,492...103,789
Ensembl chr12:59,819...100,567

G

bromodomain containing 1

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of BRD1 mRNA

NCBI chr 7:119,774,187...119,822,032
Ensembl chr 7:119,774,188...119,822,031

G

bromodomain containing 3

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of BRD3 mRNA

NCBI chr 3:10,773,163...10,829,675
Ensembl chr 3:10,775,272...10,829,577

G

bromodomain containing 8

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of BRD8 mRNA

NCBI chr18:26,204,892...26,229,999
Ensembl chr18:26,181,732...26,229,884

G

similar to human chromosome 1 open reading frame 50

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of C1ORF50 mRNA

NCBI chr 5:132,837,135...132,841,744
Ensembl chr 5:132,836,506...132,841,762

G

calcium voltage-gated channel subunit alpha1 H

multiple interactions

3-cyanoalanine inhibits the reaction [[N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Cyclophosphamide] results in increased expression of CACNA1H protein]; [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Cyclophosphamide] results in increased expression of CACNA1H protein

NCBI chr10:14,390,104...14,448,204
Ensembl chr10:14,390,113...14,448,376

G

calmodulin regulated spectrin-associated protein 1

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of CAMSAP1 mRNA

NCBI chr 3:8,746,176...8,806,067
Ensembl chr 3:8,746,176...8,806,072

G

caspase 1

increases expression
multiple interactions

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of CASP1 mRNA
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased activity of CASP1 protein]

PMID:17622302 PMID:19130485

NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383

G

caspase 3

multiple interactions
increases expression
increases activity
decreases expression

[IFNG protein co-treated with TNF protein co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in increased activity of CASP3 protein; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine affects the reaction [chromium hexavalent ion results in increased activity of CASP3 protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [SLC39A6 mutant form inhibits the reaction [trichostatin A results in increased cleavage of CASP3 protein]]; Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [SLC39A6 mutant form inhibits the reaction [trichostatin A results in increased cleavage of CASP3 protein]]]
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of CASP3 protein
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased activity of CASP3 protein
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of CASP3 mRNA

PMID:15966574 PMID:16844947 PMID:17169355 PMID:17979179 PMID:18778698 More...

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

increases activity

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased activity of CASP8 protein

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

increases activity

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased activity of CASP9 protein

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

multiple interactions
increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [AGT protein results in decreased expression of CAT protein]
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of CAT protein

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

C-C motif chemokine ligand 2

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of CCL2 mRNA

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 22

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of CCL22 mRNA

NCBI chr19:10,257,602...10,264,373
Ensembl chr19:10,257,601...10,264,400

G

C-C motif chemokine ligand 3

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of CCL3 mRNA

NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938

G

cyclin D1

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of CCND1 mRNA

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

C-C motif chemokine receptor 1

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of CCR1 mRNA

NCBI chr 8:123,556,286...123,561,841

G

C-C motif chemokine receptor 2

decreases expression
increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of CCR2 mRNA
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of CCR2 mRNA

PMID:12756304 PMID:19013360

NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100

G

CD14 molecule

multiple interactions
increases expression

[Zinc co-treated with pyrithione] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Calcitriol results in increased expression of CD14 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Calcitriol results in increased expression of CD14 protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD14 protein]; parthenolide promotes the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Calcitriol results in increased expression of CD14 protein]]; pyrithione promotes the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Calcitriol results in increased expression of CD14 protein]]
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of CD14 protein

NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261

G

CD86 molecule

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of CD86 protein

NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818

G

cadherin 1

multiple interactions

[IFNG protein co-treated with TNF protein co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in increased cleavage of CDH1 protein; Zinc inhibits the reaction [[IFNG protein co-treated with TNF protein co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in increased cleavage of CDH1 protein]

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

cyclin-dependent kinase inhibitor 1A

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of CDKN1A mRNA

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

CCAAT/enhancer binding protein delta

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of CEBPD mRNA

NCBI chr11:84,764,670...84,765,808
Ensembl chr11:84,764,565...84,765,829

G

complement factor properdin

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of CFP mRNA

NCBI chr X:1,162,014...1,167,576
Ensembl chr X:1,161,979...1,167,573

G

chloride voltage-gated channel 7

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of CLCN7 mRNA

NCBI chr10:14,151,758...14,177,130
Ensembl chr10:14,151,758...14,177,130

G

chloride voltage-gated channel Kb

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of CLCNKB mRNA

NCBI chr 5:153,710,086...153,733,162
Ensembl chr 5:153,710,094...153,732,153

G

collagen type I alpha 1 chain

multiple interactions

[zinc chloride deficiency co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in decreased expression of COL1A1 mRNA

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

CREB binding protein

multiple interactions

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [HIF1A protein binds to CREBBP protein]

NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888

G

crystallin zeta

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of CRYZ mRNA

NCBI chr 2:243,552,037...243,580,369
Ensembl chr 2:243,552,119...243,579,758

G

CTD phosphatase subunit 1

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of CTDP1 mRNA

NCBI chr18:73,854,277...73,916,232
Ensembl chr18:73,854,282...73,916,457

G

CTD small phosphatase 2

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of CTDSP2 mRNA

NCBI chr 7:62,805,398...62,825,306
Ensembl chr 7:62,805,658...62,825,302

G

catenin beta 1

multiple interactions

[IFNG protein co-treated with TNF protein co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in increased cleavage of CTNNB1 protein; Zinc inhibits the reaction [[IFNG protein co-treated with TNF protein co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in increased cleavage of CTNNB1 protein]

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

cathepsin D

multiple interactions

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Ethambutol results in increased expression of and affects the localization of CTSD protein]

NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488

G

cathepsin K

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of CTSK mRNA

NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550

G

C-X3-C motif chemokine receptor 1

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of CX3CR1 mRNA

NCBI chr 8:119,785,726...119,799,431
Ensembl chr 8:119,782,595...119,800,014

G

C-X-C motif chemokine ligand 2

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of CXCL2 mRNA

NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075

G

cytohesin 4

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of CYTH4 mRNA

NCBI chr 7:110,152,232...110,176,726
Ensembl chr 7:110,152,272...110,176,741

G

defender against cell death 1

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of DAD1 mRNA

NCBI chr15:27,677,286...27,697,120
Ensembl chr15:27,677,268...27,697,347

G

DEAD-box helicase 23

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of DDX23 mRNA

NCBI chr 7:129,797,620...129,814,909
Ensembl chr 7:129,797,614...129,814,949

G

DiGeorge syndrome critical region gene 2

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of DGCR2 mRNA

NCBI chr11:83,093,961...83,144,507
Ensembl chr11:83,094,037...83,144,502

G

diacylglycerol kinase zeta

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of DGKZ mRNA

NCBI chr 3:77,904,149...77,946,114
Ensembl chr 3:77,904,150...77,946,099

G

DEXH-box helicase 58

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of DHX58 mRNA

NCBI chr10:85,620,352...85,631,776
Ensembl chr10:85,620,357...85,631,525

G

dicer 1 ribonuclease III

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of DICER1 mRNA

NCBI chr 6:123,627,529...123,692,278
Ensembl chr 6:123,631,250...123,693,965

G

dentin sialophosphoprotein

multiple interactions
increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [NFIC protein binds to DSPP promoter]
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of DSPP mRNA; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of DSPP protein

NCBI chr14:5,565,562...5,571,669
Ensembl chr14:5,565,629...5,571,672

G

destrin, actin depolymerizing factor

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of DSTN mRNA

NCBI chr 3:131,284,647...131,311,361
Ensembl chr 3:131,284,648...131,311,379

G

dynein, cytoplasmic 1 light intermediate chain 2

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of DYNC1LI2 mRNA

NCBI chr19:531,783...554,670
Ensembl chr19:531,812...554,670

G

E2F transcription factor 1

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of E2F1 mRNA

NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361

G

EEF1A lysine methyltransferase 2

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of EEF1AKMT2 mRNA

NCBI chr 1:187,616,156...187,640,934
Ensembl chr 1:187,500,744...187,640,937

G

EGF-like-domain, multiple 7

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of EGFL7 mRNA

NCBI chr 3:9,404,622...9,416,879
Ensembl chr 3:9,407,520...9,416,879

G

egl-9 family hypoxia-inducible factor 1

increases activity
multiple interactions

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased activity of EGLN1 protein
zinc chloride inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased activity of EGLN1 protein]; Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased activity of EGLN1 protein]

PMID:16579968 PMID:16973622

NCBI chr19:52,867,900...52,907,308
Ensembl chr19:52,869,486...52,907,777

G

early growth response 1

multiple interactions

3-cyanoalanine inhibits the reaction [[N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Cyclophosphamide] results in increased expression of EGR1 protein]; [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Cyclophosphamide] results in increased expression of EGR1 protein

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

EH-domain containing 1

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of EHD1 mRNA

NCBI chr 1:203,579,850...203,602,226
Ensembl chr 1:203,579,869...203,602,212

G

E74 like ETS transcription factor 4

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of ELF4 mRNA

NCBI chr X:127,587,401...127,639,063
Ensembl chr X:127,590,650...127,630,200

G

ess-2 splicing factor homolog

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of ESS2 mRNA

NCBI chr11:83,075,893...83,085,849
Ensembl chr11:83,075,925...83,084,846

G

Fas associated via death domain

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of FADD mRNA

NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653

G

family with sequence similarity 13, member A

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of FAM13A mRNA

NCBI chr 4:88,056,521...88,155,782
Ensembl chr 4:88,058,403...88,155,860

G

Fc epsilon receptor Ia

multiple interactions

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [FCER1A protein affects the localization of PRKCB protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [FCER1A protein affects the localization of RELA protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [FCER1A protein results in increased expression of IL6 mRNA]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [FCER1A protein results in increased expression of IL6 protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [FCER1A protein results in increased expression of TNF mRNA]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [FCER1A protein results in increased expression of TNF protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [FCER1A protein results in increased phosphorylation of IKBKB protein]; Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [FCER1A protein affects the localization of RELA protein]]; Zinc Sulfate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [FCER1A protein affects the localization of RELA protein]]

NCBI chr13:85,686,099...85,692,394
Ensembl chr13:85,686,092...85,692,351

G

fasciculation and elongation protein zeta 1

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of FEZ1 mRNA

NCBI chr 8:36,544,462...36,589,684
Ensembl chr 8:36,544,535...36,589,683

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [IL2 protein results in increased expression of FOS mRNA]

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

forkhead box O3

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of FOXO3 mRNA

NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561

G

FRAT regulator of WNT signaling pathway 2

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of FRAT2 mRNA

NCBI chr 1:240,654,120...240,656,449
Ensembl chr 1:240,654,137...240,656,517

G

fizzy and cell division cycle 20 related 1

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of FZR1 mRNA

NCBI chr 7:8,332,029...8,343,953
Ensembl chr 7:8,332,029...8,343,952

G

glucose-6-phosphate dehydrogenase

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of G6PD mRNA

PMID:12888634 PMID:17018880

NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801

G

growth arrest and DNA-damage-inducible, alpha

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of GADD45A mRNA

NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115

G

GATA binding protein 1

multiple interactions

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [GATA1 protein binds to ZFPM1 protein]

NCBI chr X:14,529,706...14,537,530
Ensembl chr X:14,529,702...14,537,530

G

golgi associated, gamma adaptin ear containing, ARF binding protein 2

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of GGA2 mRNA

NCBI chr 1:176,552,046...176,585,332
Ensembl chr 1:176,552,046...176,585,361

G

Gem-interacting protein

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of GMIP mRNA

NCBI chr16:19,600,723...19,614,459
Ensembl chr16:19,600,723...19,614,027

G

golgi phosphoprotein 3-like

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of GOLPH3L mRNA

NCBI chr 2:183,151,941...183,183,094
Ensembl chr 2:183,153,301...183,183,083

G

golgi reassembly stacking protein 2

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of GORASP2 mRNA

NCBI chr 3:55,474,448...55,503,570
Ensembl chr 3:55,474,757...55,503,576

G

glutathione S-transferase alpha 1

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of GSTA1 mRNA

NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121

G

H1.2 linker histone, cluster member

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of H1-2 mRNA

NCBI chr17:41,391,106...41,392,597
Ensembl chr17:41,388,477...41,392,635

G

H2A clustered histone 18

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of H2AC18 mRNA

NCBI chr 2:183,808,398...183,808,992

G

H2B clustered histone 12

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of H2BC12 mRNA

NCBI chr17:42,485,699...42,486,162

G

H2B clustered histone 6

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of H2BC6 mRNA

NCBI chr17:41,520,775...41,521,238

G

H2B clustered histone 9

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of H2BC9 mRNA

NCBI chr17:42,470,593...42,478,590

G

H1.3 linker histone, cluster member

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of H1-3 mRNA

NCBI chr17:41,551,524...41,552,303
Ensembl chr17:41,529,667...41,552,334

G

HCLS1 associated protein X-1

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of HAX1 mRNA

NCBI chr 2:175,434,242...175,437,926
Ensembl chr 2:175,434,238...175,437,714

G

HIC ZBTB transcriptional repressor 2

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of HIC2 mRNA

NCBI chr11:83,737,075...83,789,554
Ensembl chr11:83,738,874...83,767,484

G

hypoxia inducible factor 1 subunit alpha

multiple interactions
increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [HIF1A protein binds to CREBBP protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased ubiquitination of and results in increased expression of HIF1A protein; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased stability of and results in increased expression of HIF1A protein; zinc chloride inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased stability of and results in increased expression of HIF1A protein]; Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased stability of and results in increased expression of HIF1A protein]
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of HIF1A protein

PMID:16579968 PMID:16973622

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

histone cluster 1, H2bc

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of H2BC21 mRNA

NCBI chr17:42,692,335...42,696,601
Ensembl chr17:42,694,723...42,696,642

G

histone cluster 1 H2B family member D

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of H2BC5 mRNA

NCBI chr17:42,792,887...42,793,268

G

H2.0-like homeobox

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of HLX mRNA

NCBI chr13:96,280,335...96,285,750
Ensembl chr13:96,280,339...96,285,750

G

heme oxygenase 2

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of HMOX2 mRNA

NCBI chr10:10,797,076...10,831,178
Ensembl chr10:10,797,055...10,831,148

G

hepatocyte nuclear factor 4, alpha

decreases activity
multiple interactions

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased activity of HNF4A protein
Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased activity of HNF4A protein]

NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320

G

histamine N-methyltransferase

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of HNMT mRNA

NCBI chr 3:6,591,804...6,623,821
Ensembl chr 3:6,591,463...6,624,012

G

interferon, alpha-inducible protein 27

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of IFI27 mRNA

NCBI chr 6:122,590,461...122,596,996
Ensembl chr 6:122,590,472...122,779,294

G

interferon gamma

multiple interactions

[IFNG protein co-treated with TNF protein co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in increased activity of CASP3 protein; [IFNG protein co-treated with TNF protein co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in increased cleavage of CDH1 protein; [IFNG protein co-treated with TNF protein co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in increased cleavage of CTNNB1 protein; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc results in increased secretion of IFNG protein]; Zinc inhibits the reaction [[IFNG protein co-treated with TNF protein co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in increased cleavage of CDH1 protein]; Zinc inhibits the reaction [[IFNG protein co-treated with TNF protein co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in increased cleavage of CTNNB1 protein]

PMID:16844947 PMID:17150331

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

interferon gamma receptor 1

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of IFNGR1 mRNA

NCBI chr 1:14,333,167...14,351,799
Ensembl chr 1:14,333,187...14,351,785

G

interferon gamma receptor 2

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of IFNGR2 mRNA

NCBI chr11:30,779,733...30,798,005
Ensembl chr11:30,779,733...30,798,005

G

insulin-like growth factor 1

multiple interactions

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [IGF1 protein results in increased phosphorylation of IGF1R protein]

NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296

G

insulin-like growth factor 1 receptor

multiple interactions

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [IGF1 protein results in increased phosphorylation of IGF1R protein]

NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777

G

inhibitor of nuclear factor kappa B kinase subunit beta

multiple interactions

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [FCER1A protein results in increased phosphorylation of IKBKB protein]

NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250

G

interleukin 10

multiple interactions
decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc results in decreased secretion of IL10 protein]
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of IL10 mRNA

PMID:17150331 PMID:19013360

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 10 receptor subunit alpha

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of IL10RA mRNA

NCBI chr 8:45,563,009...45,578,041
Ensembl chr 8:45,563,137...45,578,061

G

interleukin 10 receptor subunit beta

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of IL10RB mRNA

NCBI chr11:30,646,494...30,668,081
Ensembl chr11:30,652,096...30,668,074

G

interleukin 13 receptor subunit alpha 1

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of IL13RA1 mRNA

NCBI chr X:115,348,822...115,408,682
Ensembl chr X:115,348,860...115,408,681
Ensembl chr11:115,348,860...115,408,681

G

interleukin 1 beta

increases expression
multiple interactions

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of IL1B mRNA
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of IL1B protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [[Lipopolysaccharides co-treated with Nigericin] results in increased cleavage of IL1B protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [[Lipopolysaccharides co-treated with Nigericin] results in increased secretion of IL1B protein]; zinc chloride inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]]

PMID:17622302 PMID:19130485

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 2

multiple interactions

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [IL2 protein results in increased expression of FOS mRNA]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [IL2 protein results in increased phosphorylation of MAPK1 protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [IL2 protein results in increased phosphorylation of MAPK3 protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [IL2 protein results in increased phosphorylation of STAT5A protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [IL2 protein results in increased phosphorylation of STAT5B protein]

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 4

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of IL4 mRNA

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 4 receptor

decreases expression
increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of IL4R mRNA
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of IL4R mRNA

PMID:12756304 PMID:19013360

NCBI chr 1:180,115,061...180,139,981
Ensembl chr 1:180,115,120...180,139,980

G

interleukin 6

increases secretion
multiple interactions

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased secretion of IL6 protein
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [FCER1A protein results in increased expression of IL6 mRNA]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [FCER1A protein results in increased expression of IL6 protein]

PMID:16818790 PMID:18615482

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

interleukin 6 receptor

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of IL6R mRNA

NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536

G

integrator complex subunit 6

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of INTS6 mRNA

NCBI chr15:36,908,966...37,048,043
Ensembl chr15:36,933,724...37,021,527

G

IQ motif containing GTPase activating protein 2

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of IQGAP2 mRNA

NCBI chr 2:26,894,836...27,170,270
Ensembl chr 2:26,894,825...27,170,279

G

interferon regulatory factor 1

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of IRF1 mRNA

NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166

G

ISG15 ubiquitin-like modifier

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of ISG15 mRNA

NCBI chr 5:166,784,148...166,785,435
Ensembl chr 5:166,784,148...166,785,435

G

integrin subunit alpha M

multiple interactions

[Zinc co-treated with pyrithione] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Calcitriol results in increased expression of ITGAM protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Calcitriol results in increased expression of ITGAM protein]; parthenolide promotes the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Calcitriol results in increased expression of ITGAM protein]]; pyrithione promotes the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Calcitriol results in increased expression of ITGAM protein]]

NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503

G

intersectin 2

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of ITSN2 mRNA

NCBI chr 6:27,616,645...27,727,373
Ensembl chr 6:27,600,406...27,727,124

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc results in increased activity of JUN protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc Sulfate results in increased activity of JUN protein]

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

lysine acetyltransferase 6A

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of KAT6A mRNA

NCBI chr16:69,084,914...69,165,923
Ensembl chr16:69,084,914...69,163,606

G

kazrin, periplakin interacting protein

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of KAZN mRNA

NCBI chr 5:154,392,793...155,381,567
Ensembl chr 5:154,392,793...154,779,074

G

Kelch-like ECH-associated protein 1

multiple interactions

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [dexamethasone 21-methanesulfonate binds to KEAP1 protein]

NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862

G

kinesin family member 23

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of KIF23 mRNA

NCBI chr 8:62,397,908...62,425,162
Ensembl chr 8:62,397,948...62,425,072

G

keratin 8

increases expression
multiple interactions

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of KRT8 mRNA
TP53 mutant form inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of KRT8 mRNA]

NCBI chr 7:133,124,203...133,131,656
Ensembl chr 7:133,124,203...133,131,728

G

lysosomal-associated membrane protein 2

decreases expression
multiple interactions

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of LAMP2 mRNA
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Ethambutol results in increased expression of LAMP2 protein]

PMID:12888634 PMID:19063910

NCBI chr X:117,173,097...117,222,090
Ensembl chr X:117,057,606...117,260,522

G

large tumor suppressor kinase 1

multiple interactions

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc binds to LATS1 protein]

NCBI chr 1:2,160,411...2,193,640
Ensembl chr 1:2,160,411...2,193,640

G

large tumor suppressor kinase 2

decreases expression
multiple interactions

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of LATS2 mRNA
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc binds to LATS2 protein]; TP53 mutant form inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of LATS2 mRNA]

PMID:18778698 PMID:35027733

NCBI chr15:31,825,068...31,877,193
Ensembl chr15:31,825,092...31,877,220

G

DNA ligase 3

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of LIG3 mRNA

NCBI chr10:67,717,808...67,741,141
Ensembl chr10:67,717,812...67,798,414

G

leukocyte immunoglobulin like receptor A5

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of LILRA5 mRNA

NCBI chr 1:69,973,292...69,978,750
Ensembl chr 1:69,973,292...70,001,718

G

lymphotoxin alpha

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of LTA mRNA

NCBI chr20:3,618,853...3,621,324
Ensembl chr20:3,618,853...3,620,859

G

MAD2L1 binding protein

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of MAD2L1BP mRNA

NCBI chr 9:14,832,133...14,836,458
Ensembl chr 9:14,832,132...14,837,447

G

mitogen activated protein kinase kinase 5

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of MAP2K5 mRNA

NCBI chr 8:63,625,220...63,852,090
Ensembl chr 8:63,625,221...63,851,983

G

mitogen activated protein kinase 1

multiple interactions

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [IL2 protein results in increased phosphorylation of MAPK1 protein]
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [2,2'-dipyridyl disulfide results in increased phosphorylation of and results in increased activity of MAPK1 protein]

PMID:11331359 PMID:20201035

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [IL2 protein results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen activated protein kinase binding protein 1

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of MAPKBP1 mRNA

NCBI chr 3:106,947,342...106,998,368
Ensembl chr 3:106,947,827...106,996,199

G

muscleblind-like splicing regulator 2

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of MBNL2 mRNA

NCBI chr15:97,385,278...97,542,924
Ensembl chr15:97,385,244...97,542,937

G

MDM2 proto-oncogene

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of MDM2 mRNA

NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915

G

matrix metallopeptidase 10

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of MMP10 mRNA

NCBI chr 8:4,689,840...4,697,748
Ensembl chr 8:4,689,840...4,697,748

G

matrix metallopeptidase 9

multiple interactions

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Glutathione binds to MMP9 protein]

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

mitochondrial ribosomal protein L12

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of MRPL12 mRNA

NCBI chr10:105,758,410...105,762,913
Ensembl chr10:105,758,410...105,762,913

G

metallothionein 1

multiple interactions

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Glucose results in increased expression of MT1A mRNA]
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [1-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene results in increased expression of MT1 mRNA]
[N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Zinc co-treated with ochratoxin A] results in increased expression of MT1A mRNA; [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Zinc] results in increased expression of MT1A mRNA; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Nitroprusside results in increased expression of MT1A mRNA]

PMID:14617770 PMID:17018880 PMID:19720134 PMID:23056475

NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049
Ensembl chr X:10,826,032...10,827,049

G

metallothionein 1, pseudogene 3

multiple interactions

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Nitroprusside results in increased expression of MT1E mRNA]

NCBI chr17:74,786,652...74,787,040
Ensembl chr17:74,786,654...74,787,135

G

metallothionein 2A

multiple interactions

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [1-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene results in increased expression of MT2 mRNA]
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Glucose results in increased expression of MT2A mRNA]
[N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Zinc co-treated with ochratoxin A] results in increased expression of MT2A mRNA; [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Zinc] results in increased expression of MT2A mRNA; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Nickel results in increased expression of MT2A mRNA]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Nitroprusside results in increased expression of MT2A mRNA]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc results in increased expression of MT2A mRNA]

PMID:14617770 PMID:17018880 PMID:19097988 PMID:19720134 PMID:23056475

NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784

G

metal-regulatory transcription factor 1

multiple interactions
increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Nitroprusside results in increased expression of MTF1 mRNA]
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [MTF1 protein binds to SLC39A10 promoter]
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of MTF1 mRNA

PMID:12756304 PMID:12888634 PMID:17018880 PMID:21738690

NCBI chr 5:137,062,319...137,107,136
Ensembl chr 5:137,062,376...137,107,136

G

microsomal triglyceride transfer protein

decreases expression
multiple interactions

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of MTTP protein
Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of MTTP protein]

NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239

G

Metaxin 1

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of MTX1 mRNA

NCBI chr 2:174,615,460...174,621,383
Ensembl chr 2:174,615,461...174,620,982

G

MX dynamin like GTPase 2

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of MX2 mRNA

NCBI chr11:36,905,698...36,936,308
Ensembl chr11:36,906,111...36,930,342

G

MYC proto-oncogene, bHLH transcription factor

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of MYC mRNA

PMID:19013360 PMID:33645215

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

MYD88, innate immune signal transduction adaptor

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of MYD88 mRNA

NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415

G

Ngfi-A binding protein 2

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of NAB2 mRNA

NCBI chr 7:63,497,589...63,504,105
Ensembl chr 7:63,497,589...63,503,989

G

nuclear cap binding protein subunit 2

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of NCBP2 mRNA

NCBI chr11:68,821,026...68,829,863
Ensembl chr11:68,817,740...68,851,885

G

nicalin

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of NCLN mRNA

NCBI chr 7:8,211,978...8,221,938
Ensembl chr 7:8,211,996...8,221,934

G

nuclear factor I/C

multiple interactions
increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [NFIC protein binds to DSPP promoter]
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of NFIC protein

NCBI chr 7:8,278,210...8,309,936
Ensembl chr 7:8,253,361...8,309,936

G

nuclear factor kappa B subunit 1

multiple interactions
affects localization

Copper inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine affects the localization of NFKB1 protein]; Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine affects the localization of NFKB1 protein]

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

NFKB inhibitor alpha

multiple interactions
increases degradation
decreases expression

Copper inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased degradation of NFKBIA protein]; Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased degradation of NFKBIA protein]
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of NFKBIA mRNA

PMID:12756304 PMID:18615482

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

NK3 homeobox 2

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of NKX3-2 mRNA

NCBI chr14:69,183,795...69,186,182
Ensembl chr14:69,183,820...69,186,061

G

neuroligin 1

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of NLGN1 mRNA

NCBI chr 2:108,256,236...109,181,530
Ensembl chr 2:108,257,824...109,002,464

G

NLR family member X1

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of NLRX1 mRNA

NCBI chr 8:44,588,476...44,606,678
Ensembl chr 8:44,590,048...44,606,484

G

NSE4 homolog A, SMC5-SMC6 complex component

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of NSMCE4A mRNA

NCBI chr 1:185,102,075...185,109,166
Ensembl chr 1:185,094,360...185,109,166

G

nucleoporin 50

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of NUP50 mRNA

NCBI chr 7:116,047,960...116,065,231
Ensembl chr 7:116,048,021...116,066,905

G

O-linked N-acetylglucosamine (GlcNAc) transferase

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of OGT mRNA

NCBI chr X:66,771,278...66,816,148
Ensembl chr X:66,771,349...66,816,146

G

opioid receptor, mu 1

multiple interactions

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [FK 409 promotes the reaction [OPRM1 protein binds to PRKCG protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [FK 409 promotes the reaction [OPRM1 protein binds to RAF1 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [S-Nitroso-N-Acetylpenicillamine promotes the reaction [OPRM1 protein binds to PRKCG protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc promotes the reaction [OPRM1 protein binds to PRKCG protein binds to RAF1 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc promotes the reaction [OPRM1 protein binds to PRKCG protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc promotes the reaction [OPRM1 protein binds to RAF1 protein]]

PMID:18652891 PMID:21235400

NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409

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poly (ADP-ribose) polymerase 1

multiple interactions
decreases activity

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [zinc chloride results in increased expression of PARP1 protein]
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine affects the reaction [chromium hexavalent ion results in increased cleavage of PARP1 protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Hydrogen Peroxide results in increased activity of PARP1 protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc binds to PARP1 protein]
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased activity of PARP1 protein

PMID:15966574 PMID:22253048 PMID:24275069 PMID:33645215

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

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proliferating cell nuclear antigen

decreases ubiquitination

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased ubiquitination of PCNA protein

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

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phosphatidylinositol 3-kinase, catalytic subunit type 3

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of PIK3C3 mRNA

NCBI chr18:21,845,282...21,934,387
Ensembl chr18:21,845,295...21,929,048

G

phospholipid scramblase 1

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of PLSCR1 mRNA

NCBI chr 8:92,784,279...92,804,698
Ensembl chr 8:92,784,356...92,804,692

G

DNA polymerase beta

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of POLB mRNA

NCBI chr16:69,379,438...69,402,710
Ensembl chr16:69,379,400...69,404,812

G

RNA polymerase II subunit A

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of POLR2A mRNA

NCBI chr10:54,452,438...54,478,486
Ensembl chr10:54,452,441...54,478,455

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RNA polymerase II subunit D

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of POLR2D mRNA

NCBI chr18:23,418,097...23,425,228
Ensembl chr18:23,418,097...23,425,228

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paraoxonase 2

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of PON2 mRNA

NCBI chr 4:33,389,702...33,425,186
Ensembl chr 4:33,389,714...33,425,248

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POU class 4 homeobox 2

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of POU4F2 mRNA

NCBI chr19:29,486,686...29,490,327
Ensembl chr19:29,486,686...29,490,327

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peroxisome proliferator activated receptor alpha

decreases activity
multiple interactions

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased activity of PPARA protein
Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased activity of PPARA protein]

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

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protein phosphatase 2, regulatory subunit B, delta

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of PPP2R2D mRNA

NCBI chr 1:193,665,918...193,700,277
Ensembl chr 1:193,665,855...193,700,274

G

protein kinase C, beta

multiple interactions

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [FCER1A protein affects the localization of PRKCB protein]

NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536

G

protein kinase C, gamma

multiple interactions

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [FK 409 promotes the reaction [OPRM1 protein binds to PRKCG protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [S-Nitroso-N-Acetylpenicillamine promotes the reaction [OPRM1 protein binds to PRKCG protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc promotes the reaction [OPRM1 protein binds to PRKCG protein binds to RAF1 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc promotes the reaction [OPRM1 protein binds to PRKCG protein]]

PMID:18652891 PMID:21235400

NCBI chr 1:65,832,851...65,860,676
Ensembl chr 1:65,832,855...65,859,384

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proteasome 20S subunit beta 2

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of PSMB2 mRNA

NCBI chr 5:138,970,564...139,002,715
Ensembl chr 5:138,970,533...139,021,137

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pre T-cell antigen receptor alpha

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of PTCRA mRNA

NCBI chr 9:14,218,907...14,229,141
Ensembl chr 9:14,218,802...14,229,235

G

parathyroid hormone 1 receptor

multiple interactions

[zinc chloride deficiency co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in decreased expression of PTH1R mRNA

NCBI chr 8:110,693,910...110,725,458
Ensembl chr 8:110,697,485...110,719,729

G

protein tyrosine phosphatase 4A1

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of PTP4A1 mRNA

NCBI chr 9:33,214,201...33,245,046
Ensembl chr 9:33,214,208...33,221,964

G

protein tyrosine phosphatase, receptor type, N

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of PTPRN mRNA

PMID:17622302 PMID:19013360

NCBI chr 9:76,741,010...76,756,704
Ensembl chr 9:76,741,016...76,756,190

G

pseudouridine synthase 1

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of PUS1 mRNA

NCBI chr12:45,880,364...45,889,196
Ensembl chr12:45,880,440...45,889,196

G

glutamine-rich 1

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of QRICH1 mRNA

NCBI chr 8:109,216,900...109,256,472
Ensembl chr 8:109,217,376...109,261,359

G

RAD18 E3 ubiquitin protein ligase

decreases ubiquitination

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased ubiquitination of RAD18 protein

NCBI chr 4:145,735,654...145,821,102
Ensembl chr 4:145,735,654...145,821,069

G

RAD51 recombinase

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of RAD51 mRNA

NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035

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RAD51 paralog C

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of RAD51C mRNA

NCBI chr10:72,205,032...72,231,643
Ensembl chr10:72,205,032...72,231,248

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Raf-1 proto-oncogene, serine/threonine kinase

multiple interactions

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [FK 409 promotes the reaction [OPRM1 protein binds to RAF1 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc promotes the reaction [OPRM1 protein binds to PRKCG protein binds to RAF1 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc promotes the reaction [OPRM1 protein binds to RAF1 protein]]

NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317

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RB transcriptional corepressor 1

increases expression
multiple interactions

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of RB1 mRNA
TP53 mutant form inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of RB1 mRNA]

NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302

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RELA proto-oncogene, NF-kB subunit

multiple interactions

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc results in decreased activity of RELA protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc Sulfate results in decreased activity of RELA protein]
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [FCER1A protein affects the localization of RELA protein]; Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [FCER1A protein affects the localization of RELA protein]]; Zinc Sulfate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [FCER1A protein affects the localization of RELA protein]]

PMID:16606632 PMID:16818790

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

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replication initiator 1

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of REPIN1 mRNA

NCBI chr 4:77,548,724...77,554,242
Ensembl chr 4:77,548,849...77,554,257

G

RGP1 homolog, RAB6A GEF complex partner 1

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of RGP1 mRNA

NCBI chr 5:57,834,467...57,843,087
Ensembl chr 5:57,834,629...57,843,086

G

regulating synaptic membrane exocytosis 2

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of RIMS2 mRNA

NCBI chr 7:70,248,104...70,759,134
Ensembl chr 7:70,243,872...70,757,491

G

ring finger protein 187

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of RNF187 mRNA

NCBI chr10:43,709,493...43,715,392
Ensembl chr10:43,702,357...43,716,157

G

receptor tyrosine kinase-like orphan receptor 1

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of ROR1 mRNA

NCBI chr 5:114,744,311...115,088,155
Ensembl chr 5:114,744,304...115,088,155

G

ribosomal protein L10

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of RPL10 mRNA

NCBI chr X:152,054,562...152,056,769
Ensembl chr X:152,054,452...152,056,761

G

reprimo, TP53 dependent G2 arrest mediator homolog

increases expression
multiple interactions

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of RPRM mRNA
TP53 mutant form inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of RPRM mRNA]

NCBI chr 3:38,539,581...38,540,998
Ensembl chr 3:38,539,581...38,540,998

G

ribosomal protein S6 kinase A2

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of RPS6KA2 mRNA

NCBI chr 1:52,631,582...52,906,739
Ensembl chr 1:52,631,736...52,906,739

G

retinal pigment epithelium derived rhodopsin homolog

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of RRH mRNA

NCBI chr 2:218,362,195...218,374,387
Ensembl chr 2:218,362,200...218,374,599

G

ribonucleotide reductase regulatory TP53 inducible subunit M2B

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of RRM2B mRNA

NCBI chr 7:69,077,024...69,108,742
Ensembl chr 7:69,078,291...69,108,633

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RT1 class II, locus Hb, pseudogene 1

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of HLA-DPB1 mRNA

NCBI chr20:4,775,598...4,779,590
Ensembl chr20:4,774,650...4,780,618

G

RUNX family transcription factor 2

multiple interactions

[zinc chloride co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in increased expression of RUNX2 protein; [zinc chloride deficiency co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in decreased expression of RUNX2 mRNA; [zinc chloride deficiency co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in decreased expression of RUNX2 protein

NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167

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S100 calcium-binding protein A4

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of S100A4 mRNA

NCBI chr 2:176,090,951...176,093,258
Ensembl chr 2:176,091,804...176,093,254

G

S100 calcium binding protein A6

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of S100A6 mRNA

NCBI chr 2:176,100,619...176,102,181
Ensembl chr 2:176,100,899...176,102,180

G

S100 calcium binding protein A8

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of S100A8 mRNA

NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643

G

S100 calcium binding protein A9

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of S100A9 mRNA

NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230

G

secretogranin III

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of SCG3 mRNA

NCBI chr 8:76,399,777...76,442,015
Ensembl chr 8:76,399,777...76,442,015

G

SEC16 homolog A, endoplasmic reticulum export factor

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of SEC16A mRNA

NCBI chr 3:9,229,687...9,264,837
Ensembl chr 3:9,229,687...9,264,273

G

sestrin 1

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of SESN1 mRNA

NCBI chr20:45,294,876...45,387,698
Ensembl chr20:45,294,871...45,387,697

G

stratifin

increases expression
multiple interactions

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of SFN mRNA
TP53 mutant form inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of SFN mRNA]

NCBI chr 5:145,826,722...145,827,994
Ensembl chr 5:145,826,201...145,831,314

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SID1 transmembrane family, member 2

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of SIDT2 mRNA

NCBI chr 8:46,232,379...46,248,913
Ensembl chr 8:46,232,383...46,248,700

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solute carrier family 11 member 2

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of SLC11A2 mRNA

NCBI chr 7:131,503,076...131,540,246
Ensembl chr 7:131,503,081...131,540,145

G

solute carrier family 25, member 39

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of SLC25A39 mRNA

NCBI chr10:87,362,494...87,367,358
Ensembl chr10:87,362,490...87,367,260

G

solute carrier family 30 member 1

decreases expression
multiple interactions

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of SLC30A1 mRNA
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Glucose results in increased expression of SLC30A1 mRNA]
[Zinc co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in increased expression of SLC30A1 mRNA; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Nitroprusside results in increased expression of SLC30A1 mRNA]; ochratoxin A promotes the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of SLC30A1 mRNA]; Zinc inhibits the reaction [ochratoxin A promotes the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of SLC30A1 mRNA]]

PMID:12756304 PMID:17018880 PMID:19720134 PMID:23056475

NCBI chr13:103,491,037...103,494,910
Ensembl chr13:103,491,037...103,494,910

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solute carrier family 30 member 5

multiple interactions
increases expression
decreases expression

[N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with ochratoxin A] results in decreased expression of SLC30A5 mRNA; [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Zinc] results in decreased expression of SLC30A5 mRNA
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of SLC30A5 mRNA
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of SLC30A5 mRNA

PMID:15276077 PMID:17234632 PMID:19720134

NCBI chr 2:31,945,745...31,975,969
Ensembl chr 2:31,945,729...31,975,934

G

solute carrier family 30 member 6

multiple interactions

[N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with ochratoxin A] results in decreased expression of SLC30A6 mRNA; [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Zinc] results in increased expression of SLC30A6 mRNA

NCBI chr 6:21,020,931...21,050,785
Ensembl chr 6:21,020,931...21,050,785

G

solute carrier family 30 member 7

multiple interactions
increases expression

[N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with ochratoxin A co-treated with Zinc] results in decreased expression of SLC30A7 mRNA; [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Zinc] results in increased expression of SLC30A7 mRNA; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [ochratoxin A results in decreased expression of SLC30A7 mRNA]
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of SLC30A7 mRNA

PMID:15276077 PMID:17068819 PMID:19720134

NCBI chr 2:203,855,484...203,922,155
Ensembl chr 2:203,859,175...203,922,132

G

solute carrier family 30 member 8

multiple interactions

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Glucose results in decreased expression of SLC30A8 mRNA]

NCBI chr 7:83,591,993...83,627,786
Ensembl chr 7:83,591,993...83,626,305

G

solute carrier family 39 member 1

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of SLC39A1 mRNA

NCBI chr 2:175,703,413...175,709,063
Ensembl chr 2:175,703,441...175,709,058

G

solute carrier family 39 member 10

multiple interactions
increases expression

[ochratoxin A co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Zinc] results in decreased expression of SLC39A10 mRNA; [ochratoxin A co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in decreased expression of SLC39A10 mRNA; [Zinc co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in decreased expression of SLC39A10 mRNA
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of SLC39A10 mRNA; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of SLC39A10 protein
Dactinomycin inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of SLC39A10 mRNA]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [MTF1 protein binds to SLC39A10 promoter]; Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of SLC39A10 mRNA]

PMID:19720134 PMID:21738690

NCBI chr 9:54,836,841...54,960,325
Ensembl chr 9:54,876,141...54,960,325

G

solute carrier family 39 member 13

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of SLC39A13 mRNA

NCBI chr 3:77,039,411...77,047,528
Ensembl chr 3:77,037,565...77,049,226

G

solute carrier family 39 member 14

multiple interactions

[ochratoxin A co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in decreased expression of SLC39A14 mRNA

NCBI chr15:45,376,806...45,423,549
Ensembl chr15:45,376,917...45,423,524

G

solute carrier family 39 member 2

decreases expression
increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of SLC39A2 mRNA
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of SLC39A2 mRNA

PMID:12756304 PMID:18385089

NCBI chr15:24,590,738...24,592,850
Ensembl chr15:24,590,738...24,592,850

G

solute carrier family 39 member 4

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of SLC39A4 mRNA

PMID:18020946 PMID:19083439

NCBI chr 7:108,333,368...108,337,553
Ensembl chr 7:108,333,381...108,337,553

G

solute carrier family 39 member 5

decreases response to substance

SLC39A5 protein results in decreased susceptibility to N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine

NCBI chr 7:822,873...830,865
Ensembl chr 7:824,818...830,242

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solute carrier family 39 member 6

multiple interactions

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [SLC39A6 mutant form inhibits the reaction [trichostatin A results in decreased expression of BCL2 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [SLC39A6 mutant form inhibits the reaction [trichostatin A results in decreased expression of BCL2L1 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [SLC39A6 mutant form inhibits the reaction [trichostatin A results in increased cleavage of CASP3 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [SLC39A6 mutant form inhibits the reaction [trichostatin A results in increased expression of BAX protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [SLC39A6 mutant form results in decreased susceptibility to trichostatin A]; Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [SLC39A6 mutant form inhibits the reaction [trichostatin A results in decreased expression of BCL2 protein]]]; Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [SLC39A6 mutant form inhibits the reaction [trichostatin A results in decreased expression of BCL2L1 protein]]]; Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [SLC39A6 mutant form inhibits the reaction [trichostatin A results in increased cleavage of CASP3 protein]]]; Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [SLC39A6 mutant form inhibits the reaction [trichostatin A results in increased expression of BAX protein]]]; Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [SLC39A6 mutant form results in decreased susceptibility to trichostatin A]]

NCBI chr18:15,864,874...15,885,417
Ensembl chr18:15,864,875...15,885,417

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solute carrier family 7 member 1

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of SLC7A1 mRNA

NCBI chr12:6,628,288...6,703,849
Ensembl chr12:6,628,007...6,703,849

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solute carrier family 9 member A6

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of SLC9A6 mRNA

NCBI chr X:134,430,677...134,486,747
Ensembl chr X:134,420,756...134,485,375

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solute carrier organic anion transporter family, member 1c1

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of SLCO1C1 mRNA

PMID:17622302 PMID:19013360

NCBI chr 4:174,466,621...174,513,290
Ensembl chr 4:174,466,631...174,513,289

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small integral membrane protein 7

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of SMIM7 mRNA

NCBI chr16:17,274,417...17,278,336
Ensembl chr16:17,273,258...17,278,336

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synaptosome associated protein 25

multiple interactions

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Botulinum Toxins, Type A results in increased cleavage of SNAP25 protein]

NCBI chr 3:124,041,898...124,123,761
Ensembl chr 3:124,041,898...124,123,760

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superoxide dismutase 1

increases expression
multiple interactions

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of SOD1 mRNA
[N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine binds to Zinc] inhibits the reaction [SOD1 protein binds to Oligodeoxyribonucleotides]

PMID:12888634 PMID:31162603

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

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spen family transcriptional repressor

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of SPEN mRNA

NCBI chr 5:153,775,287...153,848,677
Ensembl chr 5:153,776,234...153,848,811

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secreted phosphoprotein 1

multiple interactions

[zinc chloride co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in increased expression of SPP1 mRNA; [zinc chloride deficiency co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in decreased expression of SPP1 mRNA

NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162

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SRC proto-oncogene, non-receptor tyrosine kinase

multiple interactions

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc results in increased phosphorylation of SRC protein]

NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476

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serine and arginine rich splicing factor 5

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of SRSF5 mRNA

NCBI chr 6:100,605,165...100,610,192
Ensembl chr 6:100,605,456...100,610,177

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signal transducer and activator of transcription 1

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of STAT1 mRNA

NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540

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signal transducer and activator of transcription 3

decreases expression
multiple interactions

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of STAT3 mRNA
TP53 mutant form inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of STAT3 mRNA]

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

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signal transducer and activator of transcription 5A

multiple interactions

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [IL2 protein results in increased phosphorylation of STAT5A protein]

NCBI chr10:85,785,537...85,809,869
Ensembl chr10:85,785,537...85,809,866

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signal transducer and activator of transcription 5B

multiple interactions

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [IL2 protein results in increased phosphorylation of STAT5B protein]

NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668

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STEAP4 metalloreductase

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of STEAP4 mRNA

NCBI chr 4:26,077,182...26,099,859
Ensembl chr 4:26,054,671...26,099,859

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serine/threonine kinase 10

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of STK10 mRNA

NCBI chr10:17,117,860...17,212,065
Ensembl chr10:17,117,878...17,212,061

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synergin, gamma

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of SYNRG mRNA

NCBI chr10:68,848,828...68,931,252
Ensembl chr10:68,849,642...68,931,250

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TBC1 domain family, member 8

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of TBC1D8 mRNA

NCBI chr 9:41,651,394...41,761,432
Ensembl chr 9:41,651,395...41,761,409

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transforming growth factor, beta receptor 2

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of TGFBR2 mRNA

NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228

G

thimet oligopeptidase 1

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of THOP1 mRNA

NCBI chr 7:8,632,911...8,645,339
Ensembl chr 7:8,632,916...8,645,275

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TIMP metallopeptidase inhibitor 3

increases expression
multiple interactions

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of TIMP3 mRNA
TP53 mutant form inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of TIMP3 mRNA]

NCBI chr 7:17,520,827...17,571,850
Ensembl chr 7:17,521,919...17,571,839

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TLE family member 1, transcriptional corepressor

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of TLE1 mRNA

NCBI chr 5:85,851,827...85,934,806
Ensembl chr 5:85,851,827...85,934,774

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transmembrane protein 184C

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of TMEM184C mRNA

NCBI chr19:30,345,183...30,361,275
Ensembl chr19:30,345,290...30,361,269

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tumor necrosis factor

multiple interactions

[IFNG protein co-treated with TNF protein co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in increased activity of CASP3 protein; [IFNG protein co-treated with TNF protein co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in increased cleavage of CDH1 protein; [IFNG protein co-treated with TNF protein co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in increased cleavage of CTNNB1 protein; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [[Calcitriol co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased secretion of TNF protein]; Zinc inhibits the reaction [[IFNG protein co-treated with TNF protein co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in increased cleavage of CDH1 protein]; Zinc inhibits the reaction [[IFNG protein co-treated with TNF protein co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in increased cleavage of CTNNB1 protein]
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [FCER1A protein results in increased expression of TNF mRNA]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [FCER1A protein results in increased expression of TNF protein]

PMID:16818790 PMID:16844947 PMID:20089671

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

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TNF alpha induced protein 8

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of TNFAIP8 mRNA

NCBI chr18:43,183,854...43,299,512
Ensembl chr18:43,183,916...43,299,517

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tensin 3

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of TNS3 mRNA

NCBI chr14:83,173,649...83,405,671
Ensembl chr14:83,173,649...83,405,998

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tumor protein p53

affects localization
multiple interactions
increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine affects the localization of TP53 protein
[Acetylcysteine co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] inhibits the reaction [[Zinc Sulfate co-treated with prolinedithiocarbamate] results in decreased expression of TP53 protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [[Zinc Sulfate co-treated with prolinedithiocarbamate] results in decreased expression of TP53 protein]; TP53 mutant form inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of LATS2 mRNA]; TP53 mutant form inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of STAT3 mRNA]; TP53 mutant form inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of KRT8 mRNA]; TP53 mutant form inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of RB1 mRNA]; TP53 mutant form inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of RPRM mRNA]; TP53 mutant form inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of SFN mRNA]; TP53 mutant form inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of TIMP3 mRNA]; TP53 mutant form inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of TP73 mRNA]; TP53 mutant form inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of YWHAZ mRNA]
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of TP53 protein

PMID:12888634 PMID:18778698 PMID:18951928

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

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tumor protein p73

increases expression
multiple interactions

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of TP73 mRNA
TP53 mutant form inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of TP73 mRNA]

NCBI chr 5:164,621,377...164,703,958
Ensembl chr 5:164,621,377...164,681,128

G

trafficking kinesin protein 1

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of TRAK1 mRNA

NCBI chr 8:120,984,445...121,139,357
Ensembl chr 8:120,984,431...121,139,367

G

thiosulfate sulfurtransferase

decreases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of TST mRNA

NCBI chr 7:109,948,061...109,955,378
Ensembl chr 7:109,948,062...109,957,216

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thioredoxin interacting protein

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of TXNIP mRNA

NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886

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thymidylate synthetase

increases expression

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of TYMS mRNA

NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536

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