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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:quinolinic acid
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Accession:CHEBI:16675 term browser browse the term
Definition:A pyridinedicarboxylic acid that is pyridine substituted by carboxy groups at positions 2 and 3. It is a metabolite of tryptophan.
Synonyms:exact_synonym: pyridine-2,3-dicarboxylic acid
 related_synonym: 2,3-Pyridinedicarboxylic acid;   Formula=C7H5NO4;   InChI=1S/C7H5NO4/c9-6(10)4-2-1-3-8-5(4)7(11)12/h1-3H,(H,9,10)(H,11,12);   InChIKey=GJAWHXHKYYXBSV-UHFFFAOYSA-N;   Pyridine-2,3-dicarboxylate;   SMILES=OC(=O)c1cccnc1C(O)=O
 alt_id: CHEBI:26418;   CHEBI:44529;   CHEBI:8663
 xref: Beilstein:137110;   CAS:89-00-9;   DrugBank:DB01796;   Gmelin:201344;   HMDB:HMDB0000232;   KEGG:C03722;   KNApSAcK:C00007381
 xref_mesh: MESH:D017378
 xref: PDBeChem:NTM;   PMID:11226705;   PMID:11462760;   PMID:16008534;   PMID:8724297;   Reaxys:137110;   Wikipedia:Quinolinic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:132942;   is_conjugate_acid_of CHEBI:46828


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quinolinic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acmsd aminocarboxymuconate semialdehyde decarboxylase affects abundance EXP ACMSD protein affects the abundance of Quinolinic Acid CTD PMID:17896587 NCBI chr13:39,200,412...39,245,954
Ensembl chr13:39,200,314...39,245,209 		JBrowse link
G Ahr aryl hydrocarbon receptor increases activity ISO Quinolinic Acid results in increased activity of AHR protein CTD PMID:28336214 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions		 EXP Quinolinic Acid results in increased expression of BAX mRNA
[naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in increased expression of BAX mRNA]; naringin inhibits the reaction [Quinolinic Acid results in increased expression of BAX mRNA]; Pioglitazone inhibits the reaction [Quinolinic Acid results in increased expression of BAX mRNA]		 CTD PMID:30130594 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions		 EXP Quinolinic Acid results in decreased expression of BCL2 mRNA
[naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in decreased expression of BCL2 mRNA]; naringin inhibits the reaction [Quinolinic Acid results in decreased expression of BCL2 mRNA]; Pioglitazone inhibits the reaction [Quinolinic Acid results in decreased expression of BCL2 mRNA]		 CTD PMID:30130594 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression EXP Quinolinic Acid results in increased expression of BDNF mRNA CTD PMID:15698628 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Casp3 caspase 3 increases expression
multiple interactions
increases activity		 EXP Quinolinic Acid results in increased expression of CASP3 mRNA
[naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in increased expression of CASP3 mRNA]; Gallic Acid inhibits the reaction [Quinolinic Acid results in increased activity of CASP3 protein]; naringin inhibits the reaction [Quinolinic Acid results in increased expression of CASP3 mRNA]; Pioglitazone inhibits the reaction [Quinolinic Acid results in increased expression of CASP3 mRNA]; wedelolactone inhibits the reaction [Quinolinic Acid results in increased activity of CASP3 protein]		 CTD PMID:29981346 PMID:30130594 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase multiple interactions
decreases expression
decreases activity		 EXP 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [pioglitazone inhibits the reaction [Quinolinic Acid results in decreased activity of CAT protein]]; nimesulide inhibits the reaction [Quinolinic Acid results in decreased expression of CAT protein]; pioglitazone inhibits the reaction [Quinolinic Acid results in decreased activity of CAT protein]; rofecoxib inhibits the reaction [Quinolinic Acid results in decreased expression of CAT protein] CTD PMID:20043943 PMID:20450929 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Chat choline O-acetyltransferase multiple interactions
decreases activity		 EXP Dizocilpine Maleate inhibits the reaction [Quinolinic Acid results in decreased activity of CHAT protein] CTD PMID:2976130 NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093 		JBrowse link
G Cp ceruloplasmin multiple interactions EXP [Copper Sulfate co-treated with Quinolinic Acid] results in increased activity of CP protein CTD PMID:12899943 NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075 		JBrowse link
G Dpp3 dipeptidylpeptidase 3 multiple interactions EXP Quinolinic Acid promotes the reaction [DPP3 protein binds to KEAP1 protein] CTD PMID:30876764 NCBI chr 1:202,204,683...202,228,501
Ensembl chr 1:202,204,693...202,228,541 		JBrowse link
G Drd1 dopamine receptor D1 decreases expression EXP Quinolinic Acid results in decreased expression of DRD1 protein CTD PMID:12207953 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002 		JBrowse link
G Drd2 dopamine receptor D2 increases expression EXP Quinolinic Acid results in increased expression of DRD2 protein CTD PMID:12207953 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 multiple interactions EXP GW 506033X inhibits the reaction [Quinolinic Acid results in increased expression of and results in increased cleavage of EIF2AK2 protein]; Quinolinic Acid results in increased expression of and results in increased cleavage of EIF2AK2 protein CTD PMID:24211709 NCBI chr 6:16,189,000...16,224,972
Ensembl chr 6:16,188,979...16,224,971 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation
multiple interactions		 EXP Quinolinic Acid results in increased phosphorylation of EIF2S1 protein
[Quinolinic Acid co-treated with GW 506033X] results in increased phosphorylation of EIF2S1 protein		 CTD PMID:24211709 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225 		JBrowse link
G Fgf1 fibroblast growth factor 1 decreases secretion ISO Quinolinic Acid results in decreased secretion of FGF1 protein CTD PMID:16392031 NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Quinolinic Acid results in increased expression of FOS mRNA CTD PMID:15698628 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases activity EXP Quinolinic Acid results in increased activity of G6PD protein CTD PMID:30876764 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801 		JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions		 EXP Quinolinic Acid results in increased expression of IL1B mRNA; Quinolinic Acid results in increased expression of IL1B protein
[naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in increased expression of IL1B mRNA]; Gallic Acid inhibits the reaction [Quinolinic Acid results in increased expression of IL1B protein]; GW 506033X inhibits the reaction [Quinolinic Acid results in increased expression of IL1B protein]; naringin inhibits the reaction [Quinolinic Acid results in increased expression of IL1B mRNA]; Pioglitazone inhibits the reaction [Quinolinic Acid results in increased expression of IL1B mRNA]; wedelolactone inhibits the reaction [Quinolinic Acid results in increased expression of IL1B protein]		 CTD PMID:24211709 PMID:29981346 PMID:30130594 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression		 EXP [naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in increased expression of IL6 mRNA]; Gallic Acid inhibits the reaction [Quinolinic Acid results in increased expression of IL6 protein]; naringin inhibits the reaction [Quinolinic Acid results in increased expression of IL6 mRNA]; Pioglitazone inhibits the reaction [Quinolinic Acid results in increased expression of IL6 mRNA]; wedelolactone inhibits the reaction [Quinolinic Acid results in increased expression of IL6 protein]
Quinolinic Acid results in increased expression of IL6 mRNA; Quinolinic Acid results in increased expression of IL6 protein		 CTD PMID:29981346 PMID:30130594 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions EXP Quinolinic Acid promotes the reaction [DPP3 protein binds to KEAP1 protein]; Quinolinic Acid promotes the reaction [SQSTM1 protein binds to KEAP1 protein]; Quinolinic Acid results in increased expression of and affects the localization of KEAP1 protein CTD PMID:30876764 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862 		JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO Quinolinic Acid promotes the reaction [MAPT protein binds to MAPT protein] CTD PMID:31678113 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP Quinolinic Acid results in increased activity of and affects the localization of NFE2L2 protein CTD PMID:30876764 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
decreases expression		 EXP [naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in decreased expression of PPARG mRNA]; naringin inhibits the reaction [Quinolinic Acid results in decreased expression of PPARG mRNA]; Pioglitazone inhibits the reaction [Quinolinic Acid results in decreased expression of PPARG mRNA] CTD PMID:30130594 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppif peptidylprolyl isomerase F increases response to substance ISO PPIF results in increased susceptibility to Quinolinic Acid CTD PMID:21378209 NCBI chr16:1,257,197...1,263,919
Ensembl chr16:1,257,106...1,263,913 		JBrowse link
G Rgs2 regulator of G-protein signaling 2 decreases expression EXP Quinolinic Acid results in decreased expression of RGS2 mRNA; Quinolinic Acid results in decreased expression of RGS2 protein CTD PMID:12207953 NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385 		JBrowse link
G Slc6a3 solute carrier family 6 member 3 decreases expression
increases expression		 EXP Quinolinic Acid results in decreased expression of SLC6A3 protein
Quinolinic Acid results in increased expression of SLC6A3 protein		 CTD PMID:12207953 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413 		JBrowse link
G Sod1 superoxide dismutase 1 decreases activity
multiple interactions		 EXP Quinolinic Acid results in decreased activity of SOD1 protein
Copper Sulfate inhibits the reaction [Quinolinic Acid results in decreased activity of SOD1 protein]		 CTD PMID:12899943 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions EXP Quinolinic Acid promotes the reaction [SQSTM1 protein binds to KEAP1 protein] CTD PMID:30876764 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression		 EXP 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Pioglitazone inhibits the reaction [Quinolinic Acid results in increased expression of TNF protein]]; [naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in increased expression of TNF mRNA]; naringin inhibits the reaction [Quinolinic Acid results in increased expression of TNF mRNA]; Pioglitazone inhibits the reaction [Quinolinic Acid results in increased expression of TNF mRNA]; Pioglitazone inhibits the reaction [Quinolinic Acid results in increased expression of TNF protein]
Quinolinic Acid results in increased expression of TNF mRNA; Quinolinic Acid results in increased expression of TNF protein		 CTD PMID:20450929 PMID:30130594 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    role 19854
      application 19722
        NMR chemical shift reference compound 18090
          pyridine 51
            pyridinedicarboxylic acid 30
              quinolinic acid 29
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    p-block element atom 19849
                      carbon group element atom 19766
                        carbon atom 19785
                          organic molecular entity 19785
                            organic molecule 19737
                              organic cyclic compound 19526
                                organic heterocyclic compound 18870
                                  organic heteromonocyclic compound 17791
                                    pyridines 11515
                                      pyridine 51
                                        pyridinedicarboxylic acid 30
                                          quinolinic acid 29
paths to the root