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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:carbohydrate
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Accession:CHEBI:16646 term browser browse the term
Definition:Any member of the class of organooxygen compounds that is a polyhydroxy-aldehyde or -ketone or a lactol resulting from their intramolecular condensation (monosaccharides); substances derived from these by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom; and polymeric products arising by intermolecular acetal formation between two or more such molecules (disaccharides, polysaccharides and oligosaccharides). Carbohydrates contain only carbon, hydrogen and oxygen atoms; prior to any oxidation or reduction, most have the empirical formula Cm(H2O)n. Compounds obtained from carbohydrates by substitution, etc., are known as carbohydrate derivatives and may contain other elements. Cyclitols are generally not regarded as carbohydrates.
Synonyms:exact_synonym: carbohydrates
 related_synonym: Kohlenhydrat;   Kohlenhydrate;   a carbohydrate;   carbohidrato;   carbohidratos;   glucide;   glucides;   glucido;   glucidos;   hydrates de carbone;   saccharide;   saccharides;   saccharidum
 alt_id: CHEBI:15131;   CHEBI:23008;   CHEBI:9318
 xref: Wikipedia:Carbohydrate


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1,2-dihexadecanoyl-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PLCG1 phospholipase C gamma 1 decreases activity
multiple interactions		 EXP 1,2-Dipalmitoylphosphatidylcholine results in decreased activity of PLCG1 protein
dipalmitoylphosphatidic acid inhibits the reaction [1,2-Dipalmitoylphosphatidylcholine results in decreased activity of PLCG1 protein]		 CTD PMID:2001791 NCBI chr24:29,198,536...29,213,899
Ensembl chr24:29,198,556...29,214,714 		JBrowse link
1-stearoyl-2-arachidonoylphosphatidic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PLCG1 phospholipase C gamma 1 increases activity EXP 1-stearoyl-2-arachidonoylphosphatidic acid results in increased activity of PLCG1 protein CTD PMID:2001791 NCBI chr24:29,198,536...29,213,899
Ensembl chr24:29,198,556...29,214,714 		JBrowse link
17beta-estradiol 17-glucosiduronic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLCO1B2 solute carrier organic anion transporter family member 1B2 increases transport EXP SLCO1B3 protein results in increased transport of estradiol-17 beta-glucuronide CTD PMID:20079461 NCBI chr27:26,411,008...26,496,174
Ensembl chr27:26,411,010...26,470,989 		JBrowse link
3',5'-cyclic AMP term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G P2RY2 purinergic receptor P2Y2 multiple interactions EXP [Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Cyclic AMP; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Cyclic AMP] CTD PMID:10604969 NCBI chr21:24,987,568...25,009,754
Ensembl chr21:24,992,848...24,996,059 		JBrowse link
3'-CMP term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase multiple interactions EXP [delta-hexachlorocyclohexane results in decreased activity of CDIPT protein] which results in decreased abundance of Cytidine Monophosphate; [Hexachlorocyclohexane affects the activity of CDIPT protein] which results in decreased abundance of Cytidine Monophosphate; [Inositol promotes the reaction [CDIPT protein results in increased metabolism of Cytidine Diphosphate Diglycerides]] which results in increased abundance of Cytidine Monophosphate CTD PMID:2579070 NCBI chr 6:17,910,141...17,914,573
Ensembl chr 6:17,910,192...17,914,653 		JBrowse link
8-(4-chlorophenylthio)-cAMP term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CFTR CF transmembrane conductance regulator multiple interactions EXP [1-Methyl-3-isobutylxanthine co-treated with 8-((4-chlorophenyl)thio)cyclic-3',5'-AMP] results in increased activity of CFTR protein CTD PMID:15161604 NCBI chr14:56,290,417...56,452,919
Ensembl chr14:56,290,275...56,453,977 		JBrowse link
aldehydo-D-glucose term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G INS insulin decreases abundance
multiple interactions		 EXP INS protein results in decreased abundance of Glucose
[INS protein co-treated with Glucose] results in decreased abundance of Potassium; [INS protein co-treated with Glucose] results in increased susceptibility to Digoxin; [INS protein co-treated with Glucose] results in increased uptake of Digoxin		 CTD PMID:140932 PMID:1013176 PMID:1646414 NCBI chr18:46,324,047...46,324,933
Ensembl chr18:46,324,041...46,325,122 		JBrowse link
cytidine 5'-monophosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase multiple interactions EXP [delta-hexachlorocyclohexane results in decreased activity of CDIPT protein] which results in decreased abundance of Cytidine Monophosphate; [Hexachlorocyclohexane affects the activity of CDIPT protein] which results in decreased abundance of Cytidine Monophosphate; [Inositol promotes the reaction [CDIPT protein results in increased metabolism of Cytidine Diphosphate Diglycerides]] which results in increased abundance of Cytidine Monophosphate CTD PMID:2579070 NCBI chr 6:17,910,141...17,914,573
Ensembl chr 6:17,910,192...17,914,653 		JBrowse link
D-glucitol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MAPK1 mitogen-activated protein kinase 1 increases phosphorylation EXP Sorbitol results in increased phosphorylation of MAPK1 protein CTD PMID:12639917 NCBI chr26:31,013,607...31,132,998
Ensembl chr26:31,013,607...31,132,998 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 increases phosphorylation EXP Sorbitol results in increased phosphorylation of MAPK3 protein CTD PMID:12639917 NCBI chr 6:18,109,184...18,115,728
Ensembl chr 6:18,109,222...18,114,425 		JBrowse link
D-glucose term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G INS insulin multiple interactions
decreases abundance		 EXP [INS protein co-treated with Glucose] results in decreased abundance of Potassium; [INS protein co-treated with Glucose] results in increased susceptibility to Digoxin; [INS protein co-treated with Glucose] results in increased uptake of Digoxin
INS protein results in decreased abundance of Glucose		 CTD PMID:140932 PMID:1013176 PMID:1646414 NCBI chr18:46,324,047...46,324,933
Ensembl chr18:46,324,041...46,325,122 		JBrowse link
D-mannitol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLDN4 claudin 4 increases expression EXP Mannitol results in increased expression of CLDN4 protein CTD PMID:23816505 NCBI chr 6:6,492,706...6,506,750
Ensembl chr 6:6,493,513...6,494,145 		JBrowse link
digoxin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions
increases response to substance		 EXP [ML 7 results in decreased activity of MYLK protein] affects the reaction [ABCB1 protein affects the transport of Digoxin]; [Verapamil results in decreased activity of ABCB1 protein] which affects the transport of Digoxin; ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of ALB mRNA]; ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of DAO mRNA]; ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of EBF3 mRNA]; ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of GABRQ mRNA]; ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of GLRA1 mRNA]; ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of KLK6 mRNA]; ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of MAB21L2 mRNA]; ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of SLC10A4 mRNA]; ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of SLC18A2 mRNA]; ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of TTR mRNA]; MYL9 protein modified form affects the reaction [ABCB1 protein affects the transport of Digoxin analog]
ABCB1 gene mutant form results in increased susceptibility to Digoxin; ABCB1 mutant form results in increased susceptibility to Digoxin		 CTD PMID:16594604 PMID:20510202 PMID:23186803 PMID:25419811 NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727 		JBrowse link
G ALB albumin multiple interactions EXP ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of ALB mRNA] CTD PMID:25419811 NCBI chr13:62,133,747...62,169,349
Ensembl chr13:62,053,814...62,294,709 		JBrowse link
G DAO D-amino acid oxidase multiple interactions EXP ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of DAO mRNA] CTD PMID:25419811 NCBI chr26:18,032,663...18,057,277
Ensembl chr26:18,033,392...18,057,238 		JBrowse link
G EBF3 EBF transcription factor 3 multiple interactions EXP ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of EBF3 mRNA] CTD PMID:25419811 NCBI chr28:38,489,635...38,601,800
Ensembl chr28:38,491,047...38,602,022 		JBrowse link
G GABRQ gamma-aminobutyric acid type A receptor subunit theta multiple interactions EXP ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of GABRQ mRNA] CTD PMID:25419811 NCBI chr  X:120,607,815...120,630,251
Ensembl chr  X:120,607,686...120,628,343 		JBrowse link
G GLRA1 glycine receptor alpha 1 multiple interactions EXP ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of GLRA1 mRNA] CTD PMID:25419811 NCBI chr 4:57,443,094...57,541,494
Ensembl chr 4:57,443,999...57,528,376 		JBrowse link
G INS insulin multiple interactions EXP [INS protein co-treated with Glucose] results in increased susceptibility to Digoxin; [INS protein co-treated with Glucose] results in increased uptake of Digoxin CTD PMID:140932 PMID:1013176 NCBI chr18:46,324,047...46,324,933
Ensembl chr18:46,324,041...46,325,122 		JBrowse link
G KLK6 kallikrein related peptidase 6 multiple interactions EXP ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of KLK6 mRNA] CTD PMID:25419811 NCBI chr 1:105,902,147...105,907,585 JBrowse link
G MAB21L2 mab-21 like 2 multiple interactions EXP ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of MAB21L2 mRNA] CTD PMID:25419811 NCBI chr15:48,538,912...48,541,651
Ensembl chr15:48,539,955...48,541,034 		JBrowse link
G MYL9 myosin light chain 9 multiple interactions EXP MYL9 protein modified form affects the reaction [ABCB1 protein affects the transport of Digoxin analog] CTD PMID:20510202 NCBI chr24:25,322,800...25,329,937
Ensembl chr24:25,322,800...25,329,932 		JBrowse link
G MYLK myosin light chain kinase multiple interactions EXP [ML 7 results in decreased activity of MYLK protein] affects the reaction [ABCB1 protein affects the transport of Digoxin] CTD PMID:20510202 NCBI chr33:26,663,991...26,867,370
Ensembl chr33:26,664,800...26,843,181 		JBrowse link
G SLC10A4 solute carrier family 10 member 4 multiple interactions EXP ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of SLC10A4 mRNA] CTD PMID:25419811 NCBI chr13:44,293,956...44,299,529
Ensembl chr13:44,277,094...44,299,732 		JBrowse link
G SLC18A2 solute carrier family 18 member A2 multiple interactions EXP ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of SLC18A2 mRNA] CTD PMID:25419811 NCBI chr28:27,731,709...27,809,341
Ensembl chr28:27,731,004...27,767,993 		JBrowse link
G TTR transthyretin multiple interactions EXP ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of TTR mRNA] CTD PMID:25419811 NCBI chr 7:57,940,354...57,947,084
Ensembl chr 7:57,914,381...57,947,058 		JBrowse link
dihexadecanoyl phosphatidic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PLCG1 phospholipase C gamma 1 multiple interactions
increases activity		 EXP dipalmitoylphosphatidic acid inhibits the reaction [1,2-Dipalmitoylphosphatidylcholine results in decreased activity of PLCG1 protein]
dipalmitoylphosphatidic acid results in increased activity of PLCG1 protein		 CTD PMID:2001791 NCBI chr24:29,198,536...29,213,899
Ensembl chr24:29,198,556...29,214,714 		JBrowse link
dimyristoyl phosphatidic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PLCG1 phospholipase C gamma 1 increases activity EXP dimyristoylphosphatidic acid results in increased activity of PLCG1 protein CTD PMID:2001791 NCBI chr24:29,198,536...29,213,899
Ensembl chr24:29,198,556...29,214,714 		JBrowse link
dioleoyl phosphatidic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PLCG1 phospholipase C gamma 1 increases activity EXP dioleoylphosphatidic acid results in increased activity of PLCG1 protein CTD PMID:2001791 NCBI chr24:29,198,536...29,213,899
Ensembl chr24:29,198,556...29,214,714 		JBrowse link
doxorubicin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 increases expression
affects response to substance
multiple interactions		 EXP Doxorubicin results in increased expression of ABCB1 protein
ABCB1 protein affects the susceptibility to Doxorubicin
valspodar inhibits the reaction [ABCB1 protein affects the susceptibility to Doxorubicin]; valspodar inhibits the reaction [ABCB1 protein results in decreased susceptibility to Doxorubicin]		 CTD PMID:15492788 PMID:24975508 PMID:28093773 NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727 		JBrowse link
G HGF hepatocyte growth factor decreases response to substance EXP HGF protein results in decreased susceptibility to Doxorubicin CTD PMID:15688034 NCBI chr18:21,329,688...21,410,257
Ensembl chr18:21,332,817...21,410,263 		JBrowse link
G TNNT2 troponin T2, cardiac type affects expression EXP Doxorubicin affects the expression of TNNT2 protein CTD PMID:12322705 NCBI chr 7:1,598,306...1,620,531
Ensembl chr 7:1,598,306...1,613,741 		JBrowse link
G VIP vasoactive intestinal peptide decreases expression EXP Doxorubicin results in decreased expression of VIP protein CTD PMID:3711722 NCBI chr 1:42,941,655...42,950,160
Ensembl chr 1:42,941,224...42,950,700 		JBrowse link
G XIAP X-linked inhibitor of apoptosis affects response to substance EXP XIAP affects the susceptibility to Doxorubicin CTD PMID:16953886 NCBI chr  X:95,300,234...95,356,103
Ensembl chr  X:95,331,827...95,351,582 		JBrowse link
etoposide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC1 ATP binding cassette subfamily C member 1 decreases response to substance EXP ABCC1 protein results in decreased susceptibility to Etoposide CTD PMID:12516967 NCBI chr 6:27,855,702...27,950,140
Ensembl chr 6:27,855,702...27,989,331 		JBrowse link
ganglioside GM1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GNAQ G protein subunit alpha q multiple interactions EXP G(M1) Ganglioside inhibits the reaction [mastoparan results in increased activity of and affects the localization of GNAQ protein] CTD PMID:21671308 NCBI chr 1:80,733,530...80,928,065
Ensembl chr 1:80,715,366...80,928,065 		JBrowse link
G HEXB hexosaminidase subunit beta multiple interactions EXP G(M1) Ganglioside inhibits the reaction [mastoparan results in increased secretion of HEXB protein]; G(M1) Ganglioside inhibits the reaction [Melitten results in increased secretion of HEXB protein]; G(M1) Ganglioside inhibits the reaction [Wasp Venoms results in increased secretion of HEXB protein] CTD PMID:21334356 PMID:21671308 NCBI chr 2:57,221,809...57,248,432
Ensembl chr 2:57,222,186...57,248,417 		JBrowse link
gentamycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL2 C-C motif chemokine ligand 2 increases expression EXP Gentamicins results in increased expression of CCL2 protein CTD PMID:33290828 NCBI chr 9:39,008,187...39,009,932 JBrowse link
G CLU clusterin increases expression EXP Gentamicins results in increased expression of CLU mRNA; Gentamicins results in increased expression of CLU protein CTD PMID:25034533 PMID:33290828 NCBI chr25:29,982,811...29,999,565
Ensembl chr25:29,982,811...29,999,563 		JBrowse link
G LCN2 lipocalin 2 increases expression EXP Gentamicins results in increased expression of LCN2 mRNA; Gentamicins results in increased expression of LCN2 protein CTD PMID:25034533 PMID:33290828 NCBI chr 9:55,328,118...55,342,535
Ensembl chr 9:55,328,133...55,332,038 		JBrowse link
G LOC607874 cystatin-C-like increases expression EXP Gentamicins results in increased expression of CST3 protein CTD PMID:33290828 NCBI chr23:49,562...53,618 JBrowse link
G MIR15B microRNA mir-15b affects expression EXP Gentamicins affects the expression of MIR15B mRNA CTD PMID:33290828 NCBI chr34:26,460,663...26,460,722
Ensembl chr34:26,460,645...26,460,741 		JBrowse link
G MIR30A microRNA mir-30a increases expression EXP Gentamicins results in increased expression of MIR30A mRNA CTD PMID:33290828 NCBI chr12:33,783,894...33,783,956
Ensembl chr12:33,783,891...33,783,961 		JBrowse link
G SPP1 secreted phosphoprotein 1 increases expression EXP Gentamicins results in increased expression of SPP1 protein CTD PMID:33290828 NCBI chr32:11,354,070...11,362,325
Ensembl chr32:11,353,953...11,362,069 		JBrowse link
glucose term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G INS insulin decreases abundance
multiple interactions		 EXP INS protein results in decreased abundance of Glucose
[INS protein co-treated with Glucose] results in decreased abundance of Potassium; [INS protein co-treated with Glucose] results in increased susceptibility to Digoxin; [INS protein co-treated with Glucose] results in increased uptake of Digoxin		 CTD PMID:140932 PMID:1013176 PMID:1646414 NCBI chr18:46,324,047...46,324,933
Ensembl chr18:46,324,041...46,325,122 		JBrowse link
icariin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NOS3 nitric oxide synthase 3 increases activity EXP icariin results in increased activity of NOS3 protein CTD PMID:17438405 NCBI chr16:15,054,196...15,072,454
Ensembl chr16:15,011,344...15,072,277 		JBrowse link
lipopolysaccharide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSD11B1 hydroxysteroid 11-beta dehydrogenase 1 increases expression EXP Lipopolysaccharides results in increased expression of HSD11B1 mRNA CTD PMID:21798686 NCBI chr 7:8,344,380...8,409,901
Ensembl chr 7:8,344,447...8,409,897 		JBrowse link
G HSP70 heat shock protein 70 multiple interactions EXP HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]] CTD PMID:32899721 NCBI chr12:1,285,282...1,287,670 JBrowse link
G IL1B interleukin 1 beta multiple interactions
increases expression		 EXP arsenite affects the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]] CTD PMID:32899721 NCBI chr17:37,019,329...37,033,388
Ensembl chr17:37,019,329...37,024,458 		JBrowse link
G IL6 interleukin 6 multiple interactions
increases expression		 EXP arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]] CTD PMID:32899721 NCBI chr14:36,474,268...36,478,519
Ensembl chr14:36,473,394...36,478,519 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions
increases phosphorylation		 EXP arsenite inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]] CTD PMID:32899721 NCBI chr18:51,550,003...51,558,861
Ensembl chr18:51,550,040...51,558,875 		JBrowse link
G TNF tumor necrosis factor multiple interactions
increases expression		 EXP arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]] CTD PMID:32899721 NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425 		JBrowse link
methyl beta-cyclodextrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HEXB hexosaminidase subunit beta multiple interactions EXP methyl-beta-cyclodextrin promotes the reaction [mastoparan results in increased secretion of HEXB protein] CTD PMID:21671308 NCBI chr 2:57,221,809...57,248,432
Ensembl chr 2:57,222,186...57,248,417 		JBrowse link
nitroglycerin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G REN renin decreases activity EXP Nitroglycerin results in decreased activity of REN protein CTD PMID:8640982 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012 		JBrowse link
ouabain term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G REN renin decreases secretion
multiple interactions		 EXP Ouabain results in decreased secretion of REN protein
Vanadates inhibits the reaction [Ouabain results in decreased secretion of REN protein]		 CTD PMID:6093556 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012 		JBrowse link
phosphatidylinositol 3-phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Norepinephrine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate]; [Clonidine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate; [Norepinephrine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate; Yohimbine inhibits the reaction [[Clonidine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate] CTD PMID:15958164 NCBI chr18:13,576,966...13,611,748
Ensembl chr18:13,570,999...13,611,141 		JBrowse link
troleandomycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NR1I2 nuclear receptor subfamily 1 group I member 2 increases activity EXP Troleandomycin results in increased activity of NR1I2 protein CTD PMID:27732639 NCBI chr33:23,444,367...23,456,405
Ensembl chr33:23,432,690...23,455,347 		JBrowse link
tunicamycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSP90B1 heat shock protein 90 beta family member 1 increases expression EXP Tunicamycin results in increased expression of HSP90B1 protein CTD PMID:17416481 NCBI chr15:42,456,793...42,474,122
Ensembl chr15:42,456,764...42,579,311 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression EXP Tunicamycin results in increased expression of HSPA5 protein CTD PMID:17416481 NCBI chr 9:57,850,870...57,855,607
Ensembl chr 9:57,850,922...57,855,257 		JBrowse link
UTP term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G P2RY2 purinergic receptor P2Y2 multiple interactions
increases activity		 EXP [Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Arachidonic Acid; [Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Cyclic AMP; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Arachidonic Acid]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Cyclic AMP] CTD PMID:10604969 NCBI chr21:24,987,568...25,009,754
Ensembl chr21:24,992,848...24,996,059 		JBrowse link
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Path 1
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  CHEBI ontology 501
    chemical entity 501
      atom 501
        nonmetal atom 494
          oxygen atom 448
            oxygen molecular entity 448
              organooxygen compound 423
                carbohydrates and carbohydrate derivatives 48
                  carbohydrate 48
                    D-apiofuranose + 0
                    alditol + 6
                    apulose + 0
                    carbohydrate acid + 1
                    carbohydrate derivative + 43
                    deoxy sugar + 0
                    monosaccharide + 6
                    nucleoside + 5
                    oligosaccharide + 1
                    polygalacturonide + 0
                    polysaccharide + 7
Path 2
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  CHEBI ontology 501
    subatomic particle 501
      composite particle 501
        hadron 496
          baryon 496
            nucleon 501
              atomic nucleus 496
                atom 501
                  main group element atom 494
                    p-block element atom 494
                      carbon group element atom 478
                        carbon atom 482
                          organic molecular entity 482
                            heteroorganic entity 476
                              organochalcogen compound 430
                                organooxygen compound 423
                                  carbohydrates and carbohydrate derivatives 48
                                    carbohydrate 48
                                      D-apiofuranose + 0
                                      alditol + 6
                                      apulose + 0
                                      carbohydrate acid + 1
                                      carbohydrate derivative + 43
                                      deoxy sugar + 0
                                      monosaccharide + 6
                                      nucleoside + 5
                                      oligosaccharide + 1
                                      polygalacturonide + 0
                                      polysaccharide + 7
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